Seetharaman Balasenthil, Ph.D.
Department of Translational Molecular Pathology, Division of Pathology-Lab Medicine Div
Present Title & Affiliation
Primary Appointment
Assistant Professor, Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Assistant Professor, Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2001 | Annamalai University, Tamil Nadu, IN, Biochemistry, Ph.D |
| 1997 | Annamalai University, Tamil Nadu, IN, Biochemistry, MPhil |
| 1996 | Annamalai University, Tamil Nadu, IN, Biochemistry, M.S |
| 1994 | University of Madras, Tamil Nadu, IN, Biochemistry, BS |
Postgraduate Training
| 2001-2006 | Research Fellowship, UTMDACC, Houston, Texas |
Experience & Service
Faculty Academic Appointments
Instructor, Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2013 - 2017
Instructor, Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2008 - 2013
Instructor, Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 2006 - 2008
Honors & Awards
| 2021 - 2022 | Early Career Faculty, Division of Pathology and Laboratory Medicine |
| 2006 | 1st Place AMGEN Award in Basic Science Research, UTMDACC 10th Annual Trainee Recognition Day |
| 2004 | 1st Place AMGEN Award in Basic Science Research, UTMDACC 8th Annual Trainee Recognition Day |
| 2003 | Honorable Mention, UTMDACC 7th Annual Trainee Recognition Day |
| 2002 | Honorable Mention, UTMDACC 6th Annual Trainee Recognition Day |
| 2000 | Young Scientist Award, EMSI Silver Jubilee Conference |
| 1999 - 2001 | Senior Research Fellowship, Council of Scientific and Industrial Research |
| 1996 | 2nd Prize, Quiz Competition, XXII Annual Conference of Clinical Biochemists of India |
| 1994 - 1996 | Dr. Rathinasami Endowment Special Prize for Academic and Extracurricular Activities, Annamalai Universtiy, Tamil Nadu, India |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2015. Departmental Retreat Seminar Series. Conference. Departmental Retreat Seminar Series. Houston, TX, US.
- 2013. Pancreatic cancer. Conference. Pancreatic cancer. Houston, TX, US.
- 2006. First Place Platform Presentation. Conference. First Place Platform Presentation. Houston, TX, US.
- 2004. First Place Platform Presentation. Conference. First Place Platform Presentation. Houston, TX, US.
Regional Presentations
- 2017. Optimization of Gene Editing Technology for Generation of DEAR1 Knockout in Human Breast Cancer Cells. Poster. Optimization of Gene Editing Technology for Generation of DEAR1 Knockout in Human Breast Cancer Cells. Austin, TX, US.
- 2017. The role of Ductal Epithelium Associated Ring Chromosome 1 (DEAR1) in the regulation of stem/progenitor cell properties. Poster. The role of Ductal Epithelium Associated Ring Chromosome 1 (DEAR1) in the regulation of stem/progenitor cell properties. Austin, TX, US.
- 2015. The tumor suppressor DEAR1 negatively regulates TGF beta-driven EMT in breast cancer. Poster. Austin, TX, US.
National Presentations
- 2019. Migration Signature Biomarker Panel Improves Gold Standard CA19-9 Performance for Detection of Early Stage Pancreatic Cancer in the Blood. Conference. Migration Signature Biomarker Panel Improves Gold Standard CA19-9 Performance for Detection of Early Stage Pancreatic Cancer in the Blood. Maui, HI, US.
- 2019. On the Role of DEAR1 as a novel ubiquitin ligase for ER alpha and predictor of tamoxifen response in ER positive breast cancer. Conference. AACR 2019 Annual Meeting. Atlanta, GA, US.
- 2019. Low Expression of Tumor Suppressor DEAR1 in the Triple Negative Breast Cancer Correlated with Young Age and Early Metastasis. Poster. USCAP 108th Annual Meeting. National Harbor, MD, US.
- 2015. Validation Studies Using the EDRN Pancreatic Cancer Reference Set. Invited. 29 th Early Detection Research Network (EDRN) Steering Committee Meeting, Gastrointestinal & Associated Cancers Collaborative Group Meeting. Atlanta, GA, US.
- 2004. Modulation of hormonal responsiveness by the status and subcellular localization of ER and MTA family members. Conference. Modulation of hormonal responsiveness by the status and subcellular localization of ER and MTA family members. Orlando, FL, US.
- Novel role of the tumor suppressor ductal epithelium associated ring chromosome 1 (DEAR1) in regulation of breast stem/progenitor cell properties. Conference. Novel role of the tumor suppressor ductal epithelium associated ring chromosome 1 (DEAR1) in regulation of breast stem/progenitor cell properties. San Antonio, TX, US.
- HER2 regulation of PPARγ expression and sensitivity of breast cancer cells to PPARγ ligand therapy. Conference. Hormonal Carcinogenesis Gordon Research Conference. Meriden, US.
Grant & Contract Support
| Date: | 2025 - Present |
| Title: | A novel protein-based blood test for the early detection of pancreatic cancer |
| Funding Source: | NIH-Seed GCC REACH |
| Role: | PI |
| Date: | 2024 - 2029 |
| Title: | Circulating Biomarkers and Imaging for Early Detection of Pancreatic Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 2U01CA214263-06 |
| Date: | 2024 - 2027 |
| Title: | DEAR1 in the Regulation of Epithelial-Mesenchymal Plasticity and as a Predictive Biomarker to Stratify Triple Negative Breast Cancers for Precision Therapy |
| Funding Source: | DOD |
| Role: | Co-I |
| ID: | BC231160 |
| Date: | 2024 - 2027 |
| Title: | An Integromics Approach for the Identification of high-risk IPMNs |
| Funding Source: | AACR |
| Role: | Co-I |
| ID: | 1259743 |
| Date: | 2024 - 2026 |
| Title: | Intergromic Approach for the Identification of Invasive IPMNs |
| Funding Source: | American Cancer Society |
| Role: | Co-I |
| ID: | DBG-1257713 |
| Date: | 2024 - 2026 |
| Title: | An Intergromic Approach for Identification of Invasive Intraductal Papillary Mucinous Neoplasms |
| Funding Source: | NIH/NCI |
| Role: | Co-PI |
| ID: | 1R2CA273835-01A1 |
| Date: | 2023 - 2026 |
| Title: | DEAR1 as a critical regulator of epithelial-mesenchymal plasticity to stratify triple negative breast cancers for precision therapy in an organoid model |
| Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
| Role: | Co-I |
| ID: | BC221135 |
| Date: | 2023 - 2026 |
| Title: | An Intregromic Approach for the Identification of Invasive Intraductal Papillary Mucinous Neoplasms |
| Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
| Role: | Co-I |
| ID: | PA220201 |
| Date: | 2023 - 2026 |
| Title: | An Integromics Approach for the Identification of high-risk IPMNs |
| Funding Source: | AACR |
| Role: | Co-I |
| ID: | 1040068 |
| Date: | 2023 - 2026 |
| Title: | DEAR1 as a Critical Regulator of Epithelial-Mesenchymal Plasticity to Stratify Triple-Negative Breast Cancers for Precision Therapy Using an Organoid Model |
| Funding Source: | CPRIT |
| Role: | Co-I |
| ID: | RP230255 |
| Date: | 2022 - 2025 |
| Title: | Preclinical Studies on DEAR1 as a Predictive Biomarker to Stratify Triple Negative Breast Cancers for Precision Therapy in an Organoid Model |
| Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
| Role: | Co-I |
| ID: | BC211082 |
| Date: | 2022 - 2024 |
| Title: | An Integromic Approach for Identification of Invasive Intraductal Papillary Mucinous Neoplasms |
| Funding Source: | NIH/NCI |
| Role: | Co-PI |
| ID: | 1 R21 CA273835-01 |
| Date: | 2022 - 2026 |
| Title: | Blood-based biomarkers for the early detection of pancreatic cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | PI |
| ID: | RP220443 |
| Date: | 2022 - 2025 |
| Title: | Preclinical Studies on DEAR1 as a Predictive Biomarker to Stratify Triple Negative Breast Cancers for Precision Therapy in an Organoid Model |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-I |
| ID: | RP220113 |
| Date: | 2021 - 2022 |
| Title: | Novel Regulatory Role of DEAR1 in c-Myc-mediated Stemness in Triple Negative Breast Cancer |
| Funding Source: | Division of Pathology and Laboratoty Medicine |
| Role: | PI |
| Date: | 2021 - 2023 |
| Title: | Novel Regulatory Role of DEAR1 in c-Myc-Mediated Stemness and Metastasis in Triple Negative Breast Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-PI |
| ID: | 1 R21 CA235383-01A1 |
| Date: | 2020 - 2021 |
| Title: | DEAR1 Loss as a Predictive Marker in Endometrial Uterine Serous Carcinoma |
| Funding Source: | NIH/NCI |
| Role: | PI |
| Date: | 2020 - 2023 |
| Title: | Novel regulatory role of DEAR1 in c-Myc-mediated stemness and metastasis in triple negative breast cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-PI |
| ID: | FP00008414 |
| Date: | 2018 - 2020 |
| Title: | Novel regulatory role of DEAR1 in c-Myc-mediated stemness and metastasis in triple negative breast cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-PI |
| ID: | 1 R21 CA235383-01 |
| Date: | 2018 - 2023 |
| Title: | Circulating Biomarkers and Imaging for Early Detection of Pancreatic Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | NIH/NCI-PAR-15-289 |
| Date: | 2018 - 2020 |
| Title: | Novel regulatory role of DEAR1 in c-Myc-mediated stemness and metastasis in triple negative breast cancer |
| Funding Source: | Department of Defense (DOD) |
| Role: | Co-PI |
| ID: | BC171746 |
| Date: | 2018 - 2023 |
| Title: | Predictive Biomarkers of DCIS to Invasive Breast Cancer Progression |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | NIH/NCI-PA-16-160 R01 |
| Date: | 2018 - 2021 |
| Title: | Blood-based biomarkers for the early detection of pancreatic cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-I |
| ID: | RP180607 |
| Date: | 2015 - 2018 |
| Title: | DEAR1 as a novel regulator of cell polarity and progression from DCIS to invasive breast cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-I |
| ID: | RP150403 |
| Date: | 2014 - 2016 |
| Title: | Functional Genomic Biomarker Signatures for the Early Detection of Pancreatic Cancer |
| Funding Source: | Pancreatic Moon Shot Funding |
| Role: | Co-PI |
| ID: | 710499-80-114637-21 |
| Date: | 2014 - 2015 |
| Title: | Chromosome 1p tumor suppressor DEAR1 as a novel E3 ligase for EGFR and a predictive marker for EGFR inhibitor resistance in non-small cell lung cancer |
| Funding Source: | Department of Defense (DOD) |
| Role: | PI |
| ID: | LC130939 |
| Date: | 2014 - 2017 |
| Title: | On the role of DEAR1 as a novel ubiquitin ligase for ER alpha and predictor of tamoxifen response in ER positive breast cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-PI |
| ID: | RP140657 |
| Date: | 2012 - 2015 |
| Title: | DEAR1 Loss of Function Involved in Progression of DCIS to Invasive Breast Cancer |
| Funding Source: | Department of Defense (DOD) |
| Role: | Investigator |
| ID: | DAMD BC111524 |
| Date: | 2010 - 2017 |
| Title: | Biomarkers for the Early Detection of Pancreatic Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 2U01 CA111302-10 |
| Title: | Regulation of Hypoxia Inducible Factor Alpha-Mediated Metastatic Niche by DEAR1 |
| Funding Source: | Department of Defense (DOD) |
| Role: | PI |
| ID: | BC133327 |
| Title: | Characterization of DEAR1 as a novel E3 Ubiquitin ligase for ER alpha and predictor of tamoxifen response in ER + Breast Cancer |
| Funding Source: | AVON Foundation |
| Role: | PI |
Selected Publications
Peer-Reviewed Articles
- Yao T-H, Treekitkarnmongkol W, Putluri N, Sankaran D, Nguyen T, Balasenthil S, Hurd MW, Chen M, Brand RE, Lampe PD, Kamal AHM, Putluri V, Hu TY, Maitra A, Koay EJ, Killary AM, Sen S, Kundu S. Machine Learning-Based Multimodal Biomarkers Enable Accurate Diagnosis and Early Detection of Pancreatic Ductal Adenocarcinoma. Sci Rep 16(1):658, 2026. e-Pub 2026. PMID: 41495079.
- Treekitkarnmongkol W, Dai J, Liu S, Sankaran D, Nguyen T, Balasenthil S, Hurd MW, Chen M, Katayama H, Roy-Chowdhuri S, Calin GA, Brand RE, Lampe PD, Hu TY, Maitra A, Koay EJ, Killary AM, Sen S. Blood-Based microRNA Biomarker Signature of Early-Stage Pancreatic Ductal Adenocarcinoma With Lead-Time Trajectory in Prediagnostic Samples. Gastro Hep Adv 3(8):1098-1115, 2024. e-Pub 2024. PMID: 39529638.
- Balasenthil S, Liu S, Dai J, Bamlet WR, Petersen G, Chari ST, Maitra A, Chen N, Sen S, Killary AM. Blood-based Migration Signature Biomarker Panel Discriminates Early Stage New Onset Diabetes related Pancreatic Ductal Adenocarcinoma from Type 2 Diabetes. Clin Chim Acta 551:117567, 2023. e-Pub 2023. PMID: 37774897.
- Le, UQ, Chen, N, Balasenthil, S, Lurie, E, Yang, F, Liu, S, Rubin, L, Solis Soto, LM, Raso, G, Batra, H, Sahin, AA, Wistuba, II, Killary, AM. Tumor suppressor DEAR1 regulates mammary epithelial cell fate and predicts early onset and metastasis in triple negative breast cancer. Sci Rep 12(1), 2022. e-Pub 2022. PMID: 36376460.
- Balasenthil, S, Huang, Y, Liu, S, Marsh, T, Chen, J, Stass, SA, KuKuruga, D, Brand, RE, Chen, N, Frazier, ML, Lee, JJ, Srivastava, S, Sen, S, Killary, AM. A Plasma Biomarker Panel to Identify Surgically Resectable Early-Stage Pancreatic Cancer. J Natl Cancer Inst 109(8), 2017. e-Pub 2017. PMID: 28376184.
- Haab, BB, Huang, Y, Balasenthil, S, Partyka, K, Tang, H, Anderson, MA, Allen, PJ, Sasson, AR, Zeh, H, Kaul, KL, Kletter, D, Ge, S, Bern, M, Kwon, R, Blasutig, I, Srivastava, S, Frazier, ML, Sen, S, Hollingsworth, MA, Rinaudo, JA, Killary, AM, Brand, RE. Definitive characterization of CA 19-9 in resectable pancreatic cancer using a reference set of serum and plasma specimens. PloS one 10(10), 2015. e-Pub 2015. PMID: 26431551.
- Chen, N, Balasenthil, S, Reuther, J, Frayna, A, Wang, Y, Chandler, DS, Abruzzo, L, Rashid, A, Rodriguez Canales, J, Lozano, G, Cao, Y, Lokken, E, Chen, J, Frazier, ML, Sahin, AA, Wistuba, II, Sen, S, Lott, ST, Killary, AM. Dear1 is a chromosome 1p35 tumor suppressor and master regulator of TGF-β-driven epithelial-mesenchymal transition. Cancer Discov 3(10):1172-1189, 2013. e-Pub 2013. PMID: 23838884.
- Li, DQ, Pakala, SB, Reddy, SN, Peng, S, Balasenthil, S, Deng, CX, Lee, CC, Rea, MA, Kumar, R. Metastasis-associated protein 1 is an integral component of the circadian molecular machinery. Nat Commun 4, 2013. e-Pub 2013. PMID: 24089055.
- Balasenthil, S, Chen, N, Lott, ST, Chen, J, Carter, J, Grizzle, WE, Frazier, ML, Sen, S, Killary, AM. A migration signature and plasma biomarker panel for pancreatic adenocarcinoma. Cancer Prev Res (Phila) 4(1):137-149, 2011. e-Pub 2011. PMID: 21071578.
- Kumar, R, Balasenthil, S, Manavathi, B, Rayala, SK, Pakala, SB. Metastasis-associated protein 1 and its short form variant stimulates Wnt1 transcription through promoting its derepression from Six3 corepressor. Cancer Res 70(16):6649-6658, 2010. e-Pub 2010. PMID: 20682799.
- Kumar, R, Balasenthil, S, Pakala, SB, Rayala, SK, Sahin, AA, Ohshiro, K. Metastasis-associated protein 1 short form stimulates Wnt1 pathway in mammary epithelial and cancer cells. Cancer Res 70(16):6598-6608, 2010. e-Pub 2010. PMID: 20710043.
- Lott, ST, Chen, N, Chandler, DS, Yang, Q, Wang, L, Rodriguez, M, Xie, H, Balasenthil, S, Buchholz, TA, Sahin, AA, Chaung, K, Zhang, B, Olufemi, SE, Chen, J, Adams, H, Band, V, El-Naggar, AK, Frazier, ML, Keyomarsi, K, Hunt, KK, Sen, S, Haffty, BG, Hewitt, SM, Krahe, R, Killary, AM. DEAR1 is a dominant regulator of acinar morphogenesis and an independent predictor of local recurrence-free survival in early-onset breast cancer. PLoS Med 6(5), 2009. e-Pub 2009. PMID: 19536326.
- Chakravarty, D, Nair, SS, Rajhans, R, Pitcheswara, PR, Liu, J, Balasenthil, S, Le, X, Burow, ME, Auersperg, N, Tekmal, RR, Broaddus, R, Vadlamudi, RK. Role of PELP1/MNAR signaling in ovarian tumorigenesis. Cancer Res 68(12):4902-4909, 2008. e-Pub 2008. PMID: 18559538.
- Manavathi, B, Peng, S, Rayala, SK, Talukder, AH, Wang, MH, Wang, RA, Balasenthil, S, Agarwal, N, Frishman, LJ, Kumar, R. Repression of Six3 by a corepressor regulates rhodopsin expression. Proc Natl Acad Sci U S A 104(32):13128-13133, 2007. e-Pub 2007. PMID: 17666527.
- Balasenthil, S, Gururaj, AE, Talukder, AH, Yarmand, R, Arrington, T, Haas, BJ, Braisted, JC, Kim, I, Lee, NH, Kumar, R. Identification of Pax5 as a target of MTA1 in B-cell lymphomas. Cancer Res 67(15):7132-7138, 2007. e-Pub 2007. PMID: 17671180.
- Yarmand, R, Balasenthil, S, Gururaj, AE, Talukder, AH, Wang, YH, Ju, HL, Young, SK, Zhang, X, Jones, D, Medeiros, LJ, Stephens, C, Liu, YJ, Lee, NH, Kim, I, Kumar, R. Metastasis-associated protein 1 transgenic mice:A new model of spontaneous B-cell lymphomas. Cancer Res 67(15):7062-7067, 2007. e-Pub 2007. PMID: 17671172.
- Singh, RR, Kaluarachchi, K, Chen, M, Rayala, SK, Balasenthil, S, Ma, J, Kumar, R. Solution structure and antiestrogenic activity of the unique C-terminal, NR-box motif-containing region of MTA1s. J Biol Chem 281(35):25612-25621, 2006. e-Pub 2006. PMID: 16807247.
- Balasenthil, S, Broaddus, R, Kumar, R. Expression of metastasis-associated protein 1 (MTA1) in benign endometrium and endometrial adenocarcinomas. Human Pathol 37(6):656-661, 2006. e-Pub 2006. PMID: 16733204.
- Wang, RA, Zhang, H, Balasenthil, S, Medina, D, Kumar, R. PAK1 hyperactivation is sufficient for mammary gland tumor formation. Oncogene 25(20):2931-2936, 2006. e-Pub 2006. PMID: 16331248.
- Gururaj, AE, Singh, RR, Rayala, SK, Holm, C, Den Hollander, P, Zhang, H, Balasenthil, S, Talukder, AH, Landberg, G, Kumar, R. MTA1, a transcriptional activator of breast cancer amplified sequence 3. Proc Natl Acad Sci U S A 103(17):6670-6675, 2006. e-Pub 2006. PMID: 16617102.
- Rayala, SK, Den Hollander, P, Balasenthil, S, Molli, PR, Bean, AJ, Vadlamudi, RK, Wang, RA, Kumar, R. Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) interacts with PELP1 and activates MAPK. J Biol Chem 281(7):4395-4403, 2006. e-Pub 2006. PMID: 16352611.
- Rayala, SK, Talukder, AH, Balasenthil, S, Tharakan, R, Barnes, CJ, Wang, RA, Aldaz, CM, Khan, S, Kumar, R. P21-activated kinase 1 regulation of estrogen receptor-α activation involves serine 305 activation linked with serine 118 phosphorylation. Cancer Res 66(3):1694-1701, 2006. e-Pub 2006. PMID: 16452229.
- Vadlamudi, RK, Manavathi, B, Balasenthil, S, Nair, SS, Yang, Z, Sahin, AA, Kumar, R. Functional implications of altered subcellular localization of PELP1 in breast cancer cells. Cancer Res 65(17):7724-7732, 2005. e-Pub 2005. PMID: 16140940.
- Rayala, SK, Den Hollander, P, Balasenthil, S, Yang, Z, Broaddus, R, Kumar, R. Functional regulation of oestrogen receptor pathway by the dynein light chain 1. EMBO Rep 6(6):538-544, 2005. e-Pub 2005. PMID: 15891768.
- Vadlamudi, RK, Balasenthil, S, Sahin, AA, Kies, MS, Weber, RS, Kumar, R, El-Naggar, AK. Novel estrogen receptor coactivator PELP1/MNAR gene and ERβ expression in salivary duct adenocarcinoma. Human Pathol 36(6):670-675, 2005. e-Pub 2005. PMID: 16021574.
- Vadlamudi, RK, Barnes, CJ, Rayala, SK, Li, F, Balasenthil, S, Marcus, S, Goodson, HV, Sahin, AA, Kumar, R. p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B. Mol Cell Biol 25(9):3726-3736, 2005. e-Pub 2005. PMID: 15831477.
- Vadlamudi, RK, Balasenthil, S, Broaddus, R, Gustafsson, JA, Kumar, R. Deregulation of estrogen receptor coactivator proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor in human endometrial tumors. J Clin Endocrinol Metab 89(12):6130-6138, 2004. e-Pub 2004. PMID: 15579769.
- Nair, SS, Mishra, SK, Yang, Z, Balasenthil, S, Kumar, R, Vadlamudi, RK. Potential role of a novel transcriptional coactivator PELP1 in histone H1 displacement in cancer cells. Cancer Res 64(18):6416-6423, 2004. e-Pub 2004. PMID: 15374949.
- Balasenthil, S, Barnes, CJ, Rayala, SK, Kumar, R. Estrogen receptor activation at serine 305 is sufficient to upregulate cyclin D1 in breast cancer cells. FEBS Letters 567(2-3):243-247, 2004. e-Pub 2004. PMID: 15178330.
- Vadlamudi, RK, Yarmand, R, Yang, Z, Balasenthil, S, Nguyen, D, Sahin, AA, Den Hollander, P, Kumar, R. Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes. Cancer cell 5(6):575-585, 2004. e-Pub 2004. PMID: 15193260.
- Mishra, SK, Balasenthil, S, Nguyen, D, Vadlamudi, RK. Cloning and functional characterization of PELP1/MNAR promoter. Gene 330(1-2):115-122, 2004. e-Pub 2004. PMID: 15087130.
- Balasenthil, S, Sahin, AA, Barnes, CJ, Wang, RA, Pestell, RG, Vadlamudi, RK, Kumar, R. p21-activated Kinase-1 Signaling Mediates Cyclin D1 Expression in Mammary Epithelial and Cancer Cells. J Biol Chem 279(2):1422-1428, 2004. e-Pub 2004. PMID: 14530270.
- Yang, Z, Yarmand, R, Balasenthil, S, Hortobagyi, GN, Sahin, AA, Barnes, CJ, Kumar, R. HER2 regulation of peroxisome proliferator-activated receptor γ (PPARγ) expression and sensitivity of breast cancer cells to PPARγ ligand therapy. Clinical Cancer Res 9(8):3198-3203, 2003. e-Pub 2003. PMID: 12912973.
- Balasenthil, S, Vadlamudi, RK. Functional interactions between the estrogen receptor coactivator PELP1/MNAR and retinoblastoma protein. J Biol Chem 278(24):22119-22127, 2003. e-Pub 2003. PMID: 12682072.
- Talukder, AH, Mishra, SK, Mandal, M, Balasenthil, S, Mehta, S, Sahin, AA, Barnes, CJ, Kumar, R. MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions. J Biol Chem 278(13):11676-11685, 2003. e-Pub 2003. PMID: 12527756.
- Balasenthil, S, Rao, KS, Nagini, S. Altered cytokeratin expression during chemoprevention of hamster buccal pouch carcinogenesis by S-allylcysteine. Pol J Pharmacol 55(5):793-798, 2003. e-Pub 2003. PMID: 14704476.
- Balasenthil, S, Rao, KS, Nagini, S. Retinoic acid receptor-β mRNA expression during chemoprevention of hamster cheek pouch carcinogenesis by garlic. Asia Pac J Clin Nutr 12(2):215-218, 2003. e-Pub 2003. PMID: 12810414.
- Balasenthil, S, Nagini, S. Protective effects of S-allylcysteine on hepatic glutathione and glutathione-dependent enzymes during hamster cheek pouch carcinogenesis. J Biochem Mol Biol Biophys 6(1):13-16, 2002. e-Pub 2002. PMID: 12186777.
- Balasenthil, S, Rao, KS, Nagini, S. Garlic induces apoptosis during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Oral Oncol 38(5):431-436, 2002. e-Pub 2002. PMID: 12110336.
- Balasenthil, S, Rao, KS, Nagini, S. Altered cytokeratin expression during chemoprevention of experimental hamster buccal pouch carcinogenesis by garlic. J Oral Pathol Med 31(3):142-146, 2002. e-Pub 2002. PMID: 11903819.
- Balasenthil, S, Rao, KS, Nagini, S. Apoptosis induction by S-allylcysteine, a garlic constituent, during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Cell Biochem Funct 20(3):263-268, 2002. e-Pub 2002. PMID: 12125104.
- Velmurugan, B, Bhuvaneswari, V, Balasenthil, S, Nagini, S. Lycopene, an antioxidant carotenoid modulates glutathione-dependent hepatic biotransformation enzymes during experimental gastric carcinogenesis. Nutr Res 21(8):1117-1124, 2001. e-Pub 2001.
- Saroja, M, Balasenthil, S, Ramachandran, CR, Nagini, S. Coffee enhances the development of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinomas. Oral Oncol 37(2):172-176, 2001. e-Pub 2001. PMID: 11167145.
- Arivazhagan, S, Balasenthil, S, Nagini, S. Attenuation by garlic and neem leaf extracts of sodium chloride - Enhanced gastric carcinogenesis induced by N-methyl-N′-Nitro-N-Nitrosoguanidine (MNNG) in Wistar rats. GI Cancer 3(5):375-382, 2001. e-Pub 2001.
- Bhuvaneswari, V, Velmurugan, B, Balasenthil, S, Ramachandran, CR, Nagini, S. Chemopreventive efficacy of lycopene on 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Fitoterapia 72(8):865-874, 2001. e-Pub 2001. PMID: 11731111.
- Balasenthil, S, Ramachandran, CR, Nagini, S. S-allylcysteine, a garlic constituent, inhibits 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Nutr Cancer 40(2):165-172, 2001. e-Pub 2001. PMID: 11962252.
- Balasenthil, S, Ramachandran, CR, Nagini, S. Garlic inhibits experimentally induced hamster buccal pouch carcinomas. J Biochem Mol Biol Biophys 5(4):261-266, 2001. e-Pub 2001.
- Balasenthil, S, Ramachandran, CR, Nagini, S. Prevention of 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis by garlic. Fitoterapia 72(5):524-531, 2001. e-Pub 2001. PMID: 11429247.
- Balasenthil, S, Arivazhagan, S, Nagini, S. Garlic enhances circulatory antioxidants during 7,12- dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. J Ethnopharmacol 72(3):429-433, 2000. e-Pub 2000. PMID: 10996282.
- Balasenthil, S, Nagini, S. Inhibition of 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis by S-allylcysteine. Oral Oncol 36(4):382-386, 2000. e-Pub 2000. PMID: 10899678.
- Arivazhagan, S, Balasenthil, S, Nagini, S. Garlic and neem leaf extracts enhance hepatic glutathione and glutathione dependent enzymes during N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced gastric carcinogenesis in rats. Phytother Res 14(4):291-293, 2000. e-Pub 2000. PMID: 10861977.
- Balasenthil, S, Saroja, M, Ramachandran, CR, Nagini, S. Of humans and hamsters: Comparative analysis of lipid peroxidation, glutathione, and glutathione-dependent enzymes during oral carcinogenesis. Br J Oral Maxillofac Surg 38(4):267-270, 2000. e-Pub 2000. PMID: 10922148.
- Balasenthil, S, Sahoo, GC, Nagini, S. Circulatory lipid peroxidation and antioxidants in pharyngeal cancer patients. J Biochem Mol Biol Biophys 4(5):359-362, 2000. e-Pub 2000.
- Balasenthil, S, Nagini, S. Enhancement of circulatory antioxidants by S-allylcysteine during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. J Biochem Mol Biol Biophys 4(1):35-39, 2000. e-Pub 2000.
- Balasenthil, S, Arivazhagan, S, Nagini, S. Effect of garlic on circulatory oxidant and antioxidant status during 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis. Nutr Res 20(11):1581-1589, 2000. e-Pub 2000.
- Arivazhagan S, Balasenthil S, Nagini S. Modulatory effects of garlic and neem leaf extracts on N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced oxidative stress in Wistar rats. Cell Biochem Funct 18(1):17-21, 2000. e-Pub 2000. PMID: 10686579.
- Balasenthil S, Nagini S. Garlic exerts hepatoprotective effects during 4-nitroquinoline 1-oxide-induced oral carcinogenesis in rats. Asia Pac J Clin Nutr 9(2):136-138, 2000. e-Pub 2000. PMID: 24394400.
- Balasenthil, S, Arivazhagan, S, Nagini, S. Chemoprotective effects of neem leaf extract on 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. J Clin Biochem Funct 26(1):9-15, 1999. e-Pub 1999.
- Arivazhagan, S, Balasenthil, S, Nagini, S. Modulatory effects of garlic and neem leaf extracts on circulatory lipid peroxides and antioxidants during N-methyl-N’ -nitro-N-nitrosoguanidine-induced gastric carcinogenesis. Med Sci Res 27(8):527-529, 1999. e-Pub 1999.
- Balasenthil S, Arivazhagan S, Ramachandran CR, Ramachandran V, Nagini S. Chemopreventive potential of neem (Azadirachta indica) on 7,12-dimethylbenz- [a]anthracene (DMBA) induced hamster buccal pouch carcinogenesis. J Ethnopharmacol 67(2):189-95, 1999. e-Pub 1999. PMID: 10619383.
- Arivazhagan, S, Balasenthil, S, Nagini, S. Chemopreventive potential of garlic and neem during N-methyl-N’-nitro-N-nitrosoguanidine-induced gastric carcinogenesis. Med Sci Res 27:209-212, 1999. e-Pub 1999.
- Balasenthil S, Arivazhagan S, Ramachandran CR, Nagini S. Effects of garlic on 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Cancer Detect Prev 23(6):534-8, 1999. e-Pub 1999. PMID: 10571664.
- Saroja M, Balasenthil S, Nagini S. Tissue lipid peroxidation and glutathione-dependent enzyme status in patients with oral squamous cell carcinoma. Cell Biochem Funct 17(3):213-216, 1999. e-Pub 1999. PMID: 10451543.
- Balasenthil, S, Nagini, S. Hepatoprotective effects of garlic during hamster buccal pouch carcinogenesis induced by 7,12-dimethylbenz[a]anthracene. Med Sci Res 26(12):849-851, 1998. e-Pub 1998.
- Oberg A, Bamlet W, Izmirlian G, Balasenthil S, Batra S, Hayashi M, Herman D, Hollingsworth M, Jain M, Killary A, Krusen B, Liu S, Majumder S, Natarajan G, Sen S, Smith L, Srivastava S, Wolpin B, Zaret K, Goggins M. Pancreatic Cancer Detection Consortium Biomarker Bake-Off: A Phase 2 blinded biomarker validation and panel discovery study. Clin Cancer Res.
Review Articles
- Chen, N, Balasenthil, S, Reuther, J, Killary, AM. DEAR1, a novel tumor suppressor that regulates cell polarity and epithelial plasticity. Cancer Res 74(20):5683-5689, 2014. e-Pub 2014. PMID: 25261235.
Other Articles
- Vadlamudi, RK, Yarmand, R, Yang, Z, Balasenthil, S, Nguyen, D, Sahin, AA, Den Hollander, P Overexpressed DLC1 as target for breast cancer cell shape and survival. Cancer Biology and Therapy 3(7):587-588, 2004. PMID: 15754445.
Abstracts
- Balasenthil S, Bamlet WR, Izmirlian G, Balasenthil S, Batra SK, Hayashi M, Herman D, Hollingsworth MA, Jain M, Killary AM, Krusen BM, Liu S, Natarajan G, Sen S, Smith LM, Srivastava S, Wolpin BM, Zaret KS, Goggins MG. Pancreatic Cancer Detection Consortium biomarker bake-off: A consortium Phase 2 blinded biomarker validation and panel discovery study. AACR Special Conference in Cancer Research: Advances in Pancreatic Cancer Research—Emerging Science Driving Transformative Solutions 85(18), 2025. e-Pub 2025.
- Balasenthil S, Huang Y, Liu S, Marsh T, Chen J, Stass SA, KuKuruga D, Brand R, Chen N, Frazier ML, Lee JJ, Srivastava S, Sen S, Killary AM. Migration Signature Biomarker Panel Improves Gold Standard CA19-9 Performance for Detection of Early Stage Pancreatic Cancer in the Blood. 50th Anniversary Meeting: American Pancreatic Association, Japan Pancreas Society, 2019. e-Pub 2019.
- Yang F, Le U, Chen N, Balasenthil S, Mino B, Liu S, Rubin M, Sahin A, Wistuba I, Killary A. Low Expression of Tumor Suppressor DEAR1 in the Triple Negative Breast Cancer Correlated with Young Age and Early Metastasis. USCAP 108th Annual Meeting 32(Supplement 2):164, 2019. e-Pub 2019.
- Balasenthil S, Chen N, Killary A. On the role of DEAR1 as a novel ubiquitin ligase for ER alpha and predictor of tamoxifen response in ER positive breast cancer 79(13_Supplement), 2019. e-Pub 2019.
- Le U, Chen N, Balasenthil S, Killary AM. Novel role of the tumor suppressor ductal epithelium associated ring chromosome 1 (DEAR1) in regulation of breast stem/progenitor cell properties. San Antonio Breast Cancer Symposium 79(4_Supplement):P1-07-01, 2018. e-Pub 2018.
- Le U, Chen N, Balasenthil S, Killary AM. The role of DEAR1 in the regulation of epithelial-mesenchymal transition and acquisition of stem cell properties. Mammary gland biology, Gordon Research Conference, Jun 11-16, 2017, Stowe, VT, 2017. e-Pub 2017.
- Chen N, Balasenthil S, Le U, Killary AM. The Tumor Suppressor DEAR1 Regulates Polarity and EMT in Human Mammary Epithelial Cells. Mammary gland biology, Gordon Research Seminar, Renaissance Tuscany Il Ciocco Resort Lucca (Barga), Italy, May 29-Jun 3, 2016, 2016. e-Pub 2016.
- Balasenthil S, Killary AM. Validation Studies Using the EDRN Pancreatic Cancer Reference Set. 29th Early Detection Research Network (EDRN) Steering Committee Meeting, Gastrointestinal & Associated Cancers Collaborative Group Meeting, 2015. e-Pub 2015.
- Chen N, Balasenthil S, Killary AM. The tumor suppressor DEAR1 negatively regulates TGF beta-driven EMT in breast cancer. IV Innovations in Cancer Prevention and Research Conference, Cancer Prevention& Research Institute of Texas, November 9-10 2015, Austin, TX:89, 2015. e-Pub 2015.
- Wang J, Balasenthil S, Huang Y-J, Chen J, Reuther J, Chen N, Brand R, Frazier ML, Killary AM, Sen S. A genomic pathway approach to biomarker discovery for the early detection and risk assessment of pancreatic cancer. 9th EDRN Scientific Workshop, 2014. e-Pub 2014.
- Chen N, Balasenthil S, Cao Y, Killary AM. DEAR1 orchestrates selective control over the epithelial-mesenchymal transition axis of TGFβ's function. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr C71, 2013. e-Pub 2013.
- Balasenthil S, Wang J, Huang Y-J, Chen J, Reuther J, Chen N, Brand R, Stass S, Frazier ML, Killary AM, Sen S. A functional genomic approach to biomarker discovery in pancreatic cancer. 8th EDRN Scientific Workshop, 2013. e-Pub 2013.
- Chen N, Balasenthil S, Cao Y, Killary AM. DEAR1 orchestrates selective control over the epithelial-mesenchymal transition axis of TGFβ's function. AACR Special Conference on Tumor Invasion and Metastasis 73(3_Supplement), 2013. e-Pub 2013.
- Reuther J, Chen N, Balasenthil S, Killary A. Discovery and Functional Characterization of Somatic Mutations in the Novel Tumor Suppressor DEAR1. Annual Meeting of American Society of Human Genetics, 2012. e-Pub 2012.
- Reuther J, Chen N, Balasenthil S, Killary A. The role of novel tumor suppressor DEAR1 in the regulation of apoptosis in breast cancer. Mammary Gland Biology, Gordon Research Seminar, 2012. e-Pub 2012.
- Chakravarty D, Nair S, Balasenthil S. PELP1/MNAR in ovarian cancer: implications in tumorigenesis. 98th AACR Annual Meeting 67(9_Supplement):4345, 2007. e-Pub 2007.
- Nair SS, Balasenthil S, Mueller JM, Koochekpour S, Schüle R, Kumar R, and Vadlamudi RK. PELP1/MNAR modulates LIM-only coactivator FHL2 transactivation functions. AACR 96th Annual Meeting, Anaheim, California 1279, 2005. e-Pub 2005.
- Wang RA, Balasenthil S, Kumar R. Ectopic overexpression of kinase active p21-activated kinase is sufficient to induce tumorigenesis in the mouse mammary gland. 96th AACR Annual Meeting 65(9_Supplement):249, 2005. e-Pub 2005.
- Nair SS, Balasenthil S, Mueller JM, Koochekpour S, Schule R, Kumar R, Vadlamudi RK. PELP1/MNAR modulates LIM-only coactivator FHL2 transactivation functions. 96th AACR Annual Meeting 65(9_Supplement), 2005. e-Pub 2005.
- Vadlamudi RK, Manavathi B, Balasenthil S, Yang Z, Sahin AA, Kumar R. Altered localization of ER-coregulator PELP1 promotes estrogen hypersensitivity and tamoxifen resistance. Era of Hope, DOD Breast Cancer Meeting, 2005. e-Pub 2005.
- Balasenthil S, Gururaj AE, Yang Z, Broaddus R, Vadlamudi RK, Kumar R. Modulation of hormonal responsiveness by the status and subcellular localization of ER and MTA family members. AACR 95th Annual Meeting 64(7_Supplement), 2004. e-Pub 2004.
- Vadlamudi RK, Balasenthil S, Kies M, Kumar R, El-Naggar AK. PELP1/MNAR co-activator and the hormonal receptor expression in salivary duct adenocarcinoma. 6th International Conference on Head and Neck Cancer, 2004. e-Pub 2004.
- Mishra S, Balasenthil S, Yang Z, Vadlamudi RK. PELP1/MNAR modulate ER genomic functions via histone H1 interactions. 95th AACR Annual Meeting 64(7_Supplement), 2004. e-Pub 2004.
- Kumar R, Vadlamudi RK, Barnes CJ, Balasenthil S. Signaling dependent phosphorylation of tubulin folding factor controls microtubule biogenesis and functions: a new potential target in cancer cells. 16th EORTC-NCI-AACR Symposium. Molecular Targets and cancer therapeutics, 2004. e-Pub 2004.
- Balasenthil S, Broaddus R, Kumar R, Gustafsson J-A, Vadmaludi RK. Potential Involvement of PELP1/MNAR in tamoxifen resistance. 26th Annual San Antonio Breast Cancer Symposium, 2003. e-Pub 2003.
- Balasenthil S, Vadlamudi RK. Regulatory and functional interactions between steroidal coactivator PELP1 and retinoblastoma protein. The Cell Cycle Cold Spring Harbor Laboratory Meeting, 2002. e-Pub 2002.
- Balasenthil S, Nagini S. 26th Annual Conference of Environmental Mutagen Society of India and International Symposium on Environmental Health Sciences in the 21st Century, 2001. e-Pub 2001.
- Balasenthil S, Nagini S. 25th Annual Meeting of Environmental Mutagen Society of India (EMSI), 2000. e-Pub 2000.
- Nagini S, Balasenthil S, Rao KS. S-allylcysteine induces apoptosis during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. 5th International Symposium on Biotechnology in Preventive Oncology: Impact of Cancer Biotechnology on Diagnostic and Prognostic Indicators in Predictive Oncology and Therapy; Geneva, Switzerland; October 28-31, 2000, 2000. e-Pub 2000.
- Nagini S, Balasenthil S, Rao KS. S-allylcysteine induces apoptosis during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Impact of Cancer Biotechnology on Diagnostic and Prognostic Indicators in Predictive Oncology and Therapy. 5th International Symposium on Biotechnology in Preventive Oncology:, 2000. e-Pub 2000.
- Balasenthil S, Nagini S. 15th Asia Pacific Cancer Conference, 1999. e-Pub 1999.
- Balasenthil S, Arivazhagan S, Nagini S. Indo-Japanese Symposium on Frontiers in Electron Microscopy in the 21st Century and XXII Annual Meeting of Electron Microscopy Society of India, 1998. e-Pub 1998.
Book Chapters
- Balasenthil S, Kumar R. Molecular mechanisms of the metastasis- associated gene family of coregulators: role in cancer and invasion. In: DNA Methylation,Epigenetics and Metastasis. Springer, 215-230.
Patents
- Vadlamudi RK, Kumar R, Balasenthi S. Estrogen Receptor Modulators and Uses Thereof. Patent Number: 10/927,644.
- Killary AM, Lott ST, Chen N, Balasenthil S. ASSAY FOR DETECTION OF EARLY STAGE PANCREATIC CANCER. Patent Number: 7162398.
- Killary AM, Lott S, Chen N, Balasenthil S. ASSAY FOR DETECTION OF EARLY STAGE PANCREATIC CANCER. Patent Number: 11,693,007.
- Balasenthil S. ASSAY FOR DETECTION OF EARLY STAGE PANCREATIC CANCER. Patent Number: ZL201880027192.1.
- Killary AM, Lott S, Chen N, Balasenthil S. ASSAY FOR DETECTION OF EARLY STAGE PANCREATIC CANCER. Patent Number: EP3586136B1.
Patient Reviews
CV information above last modified July 22, 2026