Shivanand Pudakalakatti, Ph.D.

Peer-Reviewed Articles

1. Whiting N, Hu J, Pudakalakatti S, McCowan CV, Ramezani S, Davis JS, Millward NZ, Engel BJ, Liu JX, Gellci K, Seo H, Brown D, Enriquez JS, Menter DG, Millward SW, Gammon ST, Piwnica-Worms D, Farach-Carson MC, Carson D, Constantinou PE, Bhattacharya P. Targeted Molecular MRI of Colorectal Cancer by Antibody Functionalized Hyperpolarized Silicon Particles. bioRxiv, 2025. e-Pub 2025. PMID: 40654854.
2. Chin, RL, Li, T, De La Cerda, J, Schuler, WF, Pudakalakatti S, Bhattacharya, PK, Sinharay, S, Pagel, MD. Potentiation of immune checkpoint blockade by esomeprazole as monitored with acidoCEST MRI. British Journal of cancer 138(8):744-753, 2025. e-Pub 2025. PMID: 39994445.
3. McCowan CV, Salmon D, Hu J, Pudakalakatti S, Whiting N, Davis JS, Carson DD, Zacharias NM, Bhattacharya PK, Farach-Carson MC. Post-Acquisition Hyperpolarized 29Silicon Magnetic Resonance Image Processing for Visualization of Colorectal Lesions Using a User-Friendly Graphical Interface. Diagnostics (Basel) 12(3), 2022. e-Pub 2022. PMID: 35328163.
4. Tripathi S, Park JH, Pudakalakatti S, Bhattacharya PK, Kaipparettu BA, Levine H. A mechanistic modeling framework reveals the key principles underlying tumor metabolism. PLoS Comput Biol 18(2):e1009841, 2022. e-Pub 2022. PMID: 35148308.
5. Pudakalakatti S, Titus M, Enriquez JS, Ramachandran S, Zacharias NM, Shureiqi I, Liu Y, Yao JC, Zuo X, Bhattacharya PK. Identifying the Metabolic Signatures of PPARD-Overexpressing Gastric Tumors. Int J Mol Sci 23(3), 2022. e-Pub 2022. PMID: 35163565.
6. Kim J, Jo D, Yang SH, Joo CG, Whiting N, Pudakalakatti S, Seo H, Son HY, Min SJ, Bhattacharya P, Huh YM, Shim JH, Lee Y. 29Si Isotope-Enriched Silicon Nanoparticles for an Efficient Hyperpolarized Magnetic Resonance Imaging Probe. ACS Appl Mater Interfaces 13(48):56923-56930, 2021. e-Pub 2021. PMID: 34793118.
7. Pudakalakatti S, Audia A, Mukhopadhyay A, Enriquez JS, Bourgeois D, Tayob N, Zacharias NM, Millward SW, Carson D, Farach-Carson MC, Lang FF, Heimberger AB, Bhat KP, Bhattacharya PK. NMR Spectroscopy-Based Metabolomics of Platelets to Analyze Brain Tumors. Reports (MDPI) 4(4), 2021. e-Pub 2021. PMID: 35937580.
8. Jaiswal AR, Liu AJ, Pudakalakatti S, Dutta P, Jayaprakash P, Bartkowiak T, Ager CR, Wang ZQ, Reuben A, Cooper ZA, Ivan C, Ju Z, Nwajei F, Wang J, Davies MA, Davis RE, Wargo JA, Bhattacharya PK, Hong DS, Curran MA. Melanoma Evolves Complete Immunotherapy Resistance through the Acquisition of a Hypermetabolic Phenotype. Cancer Immunol Res 8(11):1365-1380, 2020. e-Pub 2020. PMID: 32917656.
9. Zacharias NM, Ornelas A, Lee J, Hu J, Davis JS, Uddin N, Pudakalakatti S, Menter DG, Karam JA, Wood CG, Hawk ET, Kopetz S, Vilar E, Bhattacharya PK, Millward SW. Real-Time Interrogation of Aspirin Reactivity, Biochemistry, and Biodistribution by Hyperpolarized Magnetic Resonance Spectroscopy. Angew Chem Int Ed Engl 58(13):4179-4183, 2019. e-Pub 2019. PMID: 30680862.
10. Seo H, Choi I, Whiting N, Hu J, Luu QS, Pudakalakatti S, McCowan C, Kim Y, Zacharias N, Lee S, Bhattacharya P, Lee Y. Hyperpolarized Porous Silicon Nanoparticles: Potential Theragnostic Material for 29 Si Magnetic Resonance Imaging. Chemphyschem 19(17):2143-2147, 2018. e-Pub 2018. PMID: 29779258.
11. Uppangala S, D'Souza F, Pudakalakatti S, Atreya HS, Raval K, Kalthur G, Adiga SK. Laser assisted zona hatching does not lead to immediate impairment in human embryo quality and metabolism. Syst Biol Reprod Med 62(6):396-403, 2016. e-Pub 2016. PMID: 27598006.
12. D'Souza F, Pudakalakatti SM, Uppangala S, Honguntikar S, Salian SR, Kalthur G, Pasricha R, Appajigowda D, Atreya HS, Adiga SK. Unraveling the association between genetic integrity and metabolic activity in pre-implantation stage embryos. Sci Rep 6:37291, 2016. e-Pub 2016. PMID: 27853269.
13. Uppangala S, Pudakalakatti S, D'souza F, Salian SR, Kalthur G, Kumar P, Atreya H, Adiga SK. Influence of sperm DNA damage on human preimplantation embryo metabolism. Reprod Biol 16(3):234-241, 2016. e-Pub 2016. PMID: 27492188.
14. Venkateshaa N, Pudakalakattib SM, Qurishic Y, Atreyab HS, Srivastava C. MnFe2O4–Fe3O4 core–shell nanoparticles as a potential contrast agent for magnetic resonance imaging. Royal Society of Chemistry, 2015. e-Pub 2015.
15. PUDAKALAKATTI SM, DUBEY A, ATREYA HS. Simultaneous acquisition of three NMR spectra in a single experiment for rapid resonance assignments in metabolomics. Journal of Chemical Sciences 127:1091-1097, 2015. e-Pub 2015.
16. Pudakalakatti SM, Chandra K, Thirupathi R, Atreya HS. Rapid characterization of molecular diffusion by NMR spectroscopy. Chemistry 20(48):15719-22, 2014. e-Pub 2014. PMID: 25331210.
17. Pudakalakatti SM, Dubey A, Jaipuria G, Shubhashree U, Adiga SK, Moskau D, Atreya HS. A fast NMR method for resonance assignments: application to metabolomics. J Biomol NMR 58(3):165-73, 2014. e-Pub 2014. PMID: 24488481.
18. Pudakalakatti SM, Uppangala S, D'Souza F, Kalthur G, Kumar P, Adiga SK, Atreya HS. NMR studies of preimplantation embryo metabolism in human assisted reproductive techniques: a new biomarker for assessment of embryo implantation potential. NMR Biomed 26(1):20-7, 2013. e-Pub 2013. PMID: 22714820.

Review Articles

1. Zickus JR, Enriquez JS, Smith P, Sun BT, Wang M, Morales A, Bhattacharya PK, Pudakalakatti S. NMR-Based Metabolomic Profiling for Brain Cancer Diagnosis and Treatment Guidance. Metabolites 15(9), 2025. e-Pub 2025. PMID: 41002991.
2. Sharma G, Enriquez JS, Armijo R, Wang M, Bhattacharya P, Pudakalakatti S. Enhancing Cancer Diagnosis with Real-Time Feedback: Tumor Metabolism through Hyperpolarized 1-13C Pyruvate MRSI. Metabolites 13(5), 2023. e-Pub 2023. PMID: 37233647.
3. Pudakalakatti S, Enriquez JS, McCowan C, Ramezani S, Davis JS, Zacharias NM, Bourgeois D, Constantinou PE, Harrington DA, Carson D, Farach-Carson MC, Bhattacharya PK. Hyperpolarized MRI with silicon micro and nanoparticles: Principles and applications. Wiley Interdiscip Rev Nanomed Nanobiotechnol 13(6):e1722, 2021. e-Pub 2021. PMID: 33982426.
4. Enriquez JS, Chu Y, Pudakalakatti S, Hsieh KL, Salmon D, Dutta P, Millward NZ, Lurie E, Millward S, McAllister F, Maitra A, Sen S, Killary A, Zhang J, Jiang X, Bhattacharya PK, Shams S. Hyperpolarized Magnetic Resonance and Artificial Intelligence: Frontiers of Imaging in Pancreatic Cancer. JMIR Med Inform 9(6):e26601, 2021. e-Pub 2021. PMID: 34137725.
5. Joseph D, Sukumaran S, Chandra K, Pudakalakatti SM, Dubey A, Singh A, Atreya HS. Rapid nuclear magnetic resonance data acquisition with improved resolution and sensitivity for high-throughput metabolomic analysis. Magn Reson Chem 59(3):300-314, 2021. e-Pub 2021. PMID: 33030750.
6. Dutta P, Salzillo TC, Pudakalakatti S, Gammon ST, Kaipparettu BA, McAllister F, Wagner S, Frigo DE, Logothetis CJ, Zacharias NM, Bhattacharya PK. Assessing Therapeutic Efficacy in Real-time by Hyperpolarized Magnetic Resonance Metabolic Imaging. Cells 8(4), 2019. e-Pub 2019. PMID: 30978984.

Other Articles

1. Pudakalakatti S, Chin R, Pagel MD, Bhattacharya PK Magnetic Resonance Techniques for Assessing in Vivo pH. Archives of Cancer Research and Medicine 2(1), 2022.

Abstracts

1. Smith PL, Enriquez JS, Howell R, Roux OL, Pudakalakatti S, Dutta P, McAllister F, Bhattacharya P. Early detection of pancreatic cancer by hyperpolarized magnetic resonance, 2024. e-Pub 2024.
2. Murley, Abigail G, Pudakalakatti, Shivanand, Padron, William, Wang, Muxin, Armijo, Ryan, Delacerda, Jorge, Dominic A, Chin, Renee, Schuler, William, Rai, Kunal, Pagel, Marty, Bhattacharya, Pratip. Immunotherapy Sensitization via Tumor Acidosis Mitigation by Esomeprazole Monitored with MRI 8:130, 2024. e-Pub 2024.
3. Garcia, Ashley, Enriquez, Jose, Pudakalakatti, Shivanand, Dutta, Prasanta, McAllister, Florencia, Wang, Muxin, Armijo, Ryan, Bhattacharya, Pratip K, PhD. Distinction Between Pancreatitis and Early-Stage Pancreatic Cancer with HP-MRI, 2023. e-Pub 2023.
4. Sharma, Shankararama, Cheredath, Aswathi, Pudakalakatti, Shivanand M, Uppangala, Shubhashree, Kalthur, Guruprasad, Kumar, Pratap, Atreya, Hanudatta S, Adiga, Satish K, Pal, Debnath. Supporting Information: Using Metabolomics and Machine Learning to Establish a Model to Predict Embryo Implantation Potential:1-5, 2023. e-Pub 2023.
5. Enriquez JS, Baran N, Pudakalakatti S, Konopleva M, Bhattacharya AP. Assessment of treatment efficacy in T-cell acute lymphoblastic leukemia models with Hyperpolarized MR and NMR metabolomics, 2022. e-Pub 2022.
6. Jung, Kwanghwa, Park, Junhyoung, Sirupangi, Tirupataiah, Jia, Dongya, Gandhi, Nishant, Pudakalakatti, Shivanand, Elswood, Jessica, Porter, Weston, Putluri, Nagireddy, Zhang, H-F X, Chen, Xi, Bhattacharya, Pratip K, Creighton, Chad J, Lewis, Michael T, Rosen, Jeffrey M, Wong, Lee-Jun C, Das, Gokul M, Osborne, Kent C, Rimawi, Mothaffar F, Kaipparettu, Abraham B. Abstract P3-06-12: Autophagy-mediated survival mechanism to c-Src inhibitor therapy in triple negative breast cancer 80, 2020. e-Pub 2020.
7. Jaiswal, Ashvin R, Liu, Arthur J, Pudakalakatti, Shivanand, Dutta, Prasanta, Jayaprakash, Priyamvada, Bartkowiak, Todd, Ager, Casey R, Wang, Zhi-Qiang, Reuben, Alexandre, Cooper, Zachary A, Ivan, Cristina, Ju, Zhenlin, Nwajei, Felix, Wang, Jing, Davies, Michael A, Davis, Eric R, Wargo, Jennifer A, Bhattacharya, Pratip K, Hong, David S, Curran, Michael A. Melanoma Evolves Complete Immunotherapy Resistance through the Acquisition of a Hypermetabolic Phenotype, 2020. e-Pub 2020.
8. Jung, KH, Park, JH, Sirupangi, T, Jia, D, Gandhi, N, Pudakalakatti, S, Elswood, J, Porter, W, Putluri, N, Zhang, XH-F, Chen, X, Bhattacharya, PK, Creighton, CJ, Lewis, MT, Rosen, JM, Wong, L-JC, Das, GM, Osborne, CK, Rimawi, MF, Kaipparettu, BA. Abstract P2-02-14: Metabolic regulation and drug resistance in c-Src activated triple negative breast cancer, 2019. e-Pub 2019.
9. Jaiswal, Ashvin R, Pudakalakatti, Shivanand, Prasanta, Dutta, Liu, Arthur, Bartkowiak, Todd, Ager, Casey, Davies, Michael A, Davis, Richard E, Wargo, Jennifer, Bhattacharya, Pratip K, Hong, David S, Curran, Michael A. Metabolic adaptations confer immunotherapy resistance in melanoma 78(13):1700-1700, 2018. e-Pub 2018.
10. Dutta P, Pudakalakatti S, Jaiswal A, Curran M, Bhattacharya P. Distinguishing Immunotherapy Resistant and Sensitive Melanoma Xenografts Using 13C-MRS of Hyperpolarized Pyruvate and 1H-NMR Metabolomics 45(6):E579-E579, 2018. e-Pub 2018.
11. Whiting N, Hu J, Pudakalakatti S, McCowan C, Seo H, Lee Y, Bhattacharya P. Improved Hyperpolarization of Solid and Mesoporous Nanoscale Silicon Particles Using TEMPO Radicals Allows In Vivo 29Si MRI(26):3575, 2018. e-Pub 2018.
12. Jaiswal, Ashvin R, Pudakalakatti, Shivanand, Dutta, Prasanta, Liu, Arthur, Bartkowiak, Todd, Ager, Casey, Ivan, Cristina, Davis, Eric R, Davies, Michael A, Wargo, Jennifer, Allison, James P, Bhattacharya, Pratip K, Hong, David, Curran, Michael A. Metabolic adaptations establish immunotherapy resistance in melanoma, 2018. e-Pub 2018.
13. Whiting N, Hu J, Pudakalakatti S, McCowan C, Carson D, Davis J, Millward N, Menter D, Constantinou P, Bhattacharya AP. In Vivo Molecular Imaging of MUC1-Expressing Colorectal Tumors Using Targeted Hyperpolarized Silicon Particles(26):0105, 2018. e-Pub 2018.
14. Jung, Hwa K, Park, Hyoung J, Sirupangi, Tirupataiah, Jia, Dongya, Pudakalakatti, Shivanand, Gandhi, Nishant, Elswood, Jessica, Putluri, Vasanta, Creighton, Chad J, Porter, Weston, Lewis, Michael T, Chen, Xi, Putluri, Nagireddy, Bhattacharya, Pratip K, Wong, Lee-Jun C, Das, Gokul M, Kaipparettu, Benny A. Inhibition of mitochondrial reprogramming regulated c-Src in triple-negative breast cancer activates autophagy-mediated survival mechanism, 2018. e-Pub 2018.
15. Pudakalakatti S, Jaiswal A, Dutta P, Curran M, Bhattacharya AP. Unique molecular signatures to distinguish immunotherapy responding and resistant cell lines in melanoma by NMR spectroscopy and MR hyperpolarization(25):5595, 2017. e-Pub 2017.
16. Pudakalakatti S, Murley, GA, Padron, W, Delacerda, J, Morales, A, Wang, M, Chin, R, Schuler, W, Enriquez, J, Rai, K, Pagel, MD, Bhattacharya, PK. Targeting metabolism to interrogate immunotherapy resistance in melanoma and predicting therapy efficacy employing HP-MRSI. ISMRM.

Book Chapters

1. Pudakalakatti, S, Raj, P, Salzillo, TC, Enriquez, JS, Bourgeois, D, Dutta, P, Titus, M, Shams, S, Bhosale, PR, Kim, M, McAllister, F, Bhattacharya, PK. Metabolic Imaging Using Hyperpolarization for Assessment of Premalignancy, 169-180, 2022.
2. Pudakalakatti S, Raj P, Salzillo TC, Florencia M, Titus M, Dutta P, et al. Cancer Immunoprevention: Methods and Protocols. In: Methods in Molecular Biology, 2022.
3. Dubey A, Pudakalakatti S, Atreya HS. Fast NMR Methods for Identification of Resonances and Metabolic Pathways. In: NMR-Based Metabolomics, 135-137, 2019.
4. Lin C, Salzillo TC, Bader DA, Wilkenfeld SR, Awad D, Pulliam TL, Dutta P, Pudakalakatti S, Titus M, McGuire SE, Bhattacharya PK, Frigo DE. Prostate Cancer Energetics and Biosynthesis. In: Prostate Cancer - Cellular and Genetic Mechanisms of Disease Development and Progression, 2019.
5. Salzillo TC, Hu J, Nguyen L, Whiting N, Lee J, weygand J, Dutta P, Pudakalakatti S, et al. Interrogating metabolism in brain cancer. In: Magnetic Resonance Imaging Clinics of North America, 2016.