Subha Perni, M.D.
Department of CNS - Rad Onc Clinical, Division of Radiation Oncology
About Dr. Subha Perni
I am a radiation oncologist with clinical expertise in cancers of the central nervous system. My research focuses on improving clinical outcomes for patients with brain and spine cancers using advanced technologies. I also conduct health services research, with particular emphasis on supporting ethical and effective patient and clinician decision-making as well as clinical trial enrollment and experience.
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Present Title & Affiliation
Primary Appointment
Assistant Professor, Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Assistant Professor (Joint appointment), Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Assistant Professor, Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Assistant Professor, Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Clinical Interests
Adult primary and secondary tumors of the central nervous system
Education & Training
Degree-Granting Education
| 2017 | Columbia University College of Physicians and Surgeons, New York City, New York, US, MD |
| 2011 | Princeton University, Princeton, New Jersey, US, Philosophy, AB |
Postgraduate Training
| 2018-2022 | Clinical Residency, Radiation Oncology, Harvard Radiation Oncology Program, Boston, Massachusetts |
| 2017-2018 | Transitional Year, Memorial Sloan Kettering Cancer Center, New York, New York |
Licenses & Certifications
| 2024 | Basic Life Support (BLS) |
| 2023 | American Board of Radiology (ABR) |
| 2023 | Florida Medical License |
| 2022 | Drug Enforcement Administration (DEA) |
| 2022 | Texas Medical License (TMB) |
Experience & Service
Administrative Appointments/Responsibilities
Associate Patient Safety and Quality Officer, CNS Radiation Oncology, The University of MD Anderson Cancer Center, Houston, TX, 2026 - Present
Medical Student Site Director, CNS Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2023 - Present
Other Professional Positions
Fellowship at Auschwitz for the Study of Professional Ethics, Columbia University Herbert Irving Cancer Center, New York, New York, 2016 - 2016
Princeton Alumnicorps Fellow, Primary Care Coalition, Silver Spring, MD, 2011 - 2012
Extramural Institutional Committee Activities
Abstract Reviewer, Annual Meeting Committee CNS Track, American Society of Radiation Oncology, 2025 - Present
Participant, MDA Brain Tumor Center Clinical Trial Priority Working Group, The University of Texas MD Anderson Cancer Center, 2023
Chair (2025-Present), Member (2022-2024), Annual Meeting Education Committee, American Society of Radiation Oncology, 2022 - Present
Member, Residency Interview Committee, The University of Texas MD Anderson Cancer Center, 2022 - Present
Radiation Oncology Representative, MDA Brain Tumor Center Patient Education Working Group, The University of Texas MD Anderson Cancer Center, 2022
Member, MD Anderson Particle Therapy Value Task Force, The University of Texas MD Anderson Cancer Center, 2022
Member, Patient Education Working Group, Radiation Oncology Educational Collaborative Study Group, 2021 - Present
Co-Lead, Harvard Radiation Oncology Program Steering Group Education Committee, Massachusetts General Hospital, 2021 - 2022
Member, Humanism Curriculum Implementation Group, Massachusetts General Hospital, 2021 - 2022
Member, Brigham and Women’s Radiation Oncology Diversity, Equity, & Inclusion Committee, Brigham and Women's Hospital, 2020 - 2022
Co-Chair, Harvard Radiation Oncology Program Evaluation Committee, Massachusetts General Hospital, 2020 - 2022
Member, Massachusetts General Hospital House Staff Committee, Massachusetts General Hospital, 2020 - 2021
Member, Massachusetts Medical Society Ethics Committee, Massachusetts Medical Society, 2019 - 2022
Representative, Memorial Sloan Kettering Cancer Center Ethics Committee, Memorial Sloan Kettering Cancer Center, 2017 - 2018
Editorial Activities
Guest Editor, AMA Journal of Ethics theme issue on moral distress, 2016
Editor, Columbia Voices in Bioethics, 2015 - 2017
Honors & Awards
| 2021 | Quality Symposium Merit Award, American Society of Clinical Oncology |
| 2021 | Merit Award, American Society of Clinical Oncology |
| 2019 | Resident/Fellow Election to Massachusetts Medical Society Ethics Committee, Massachusetts Medical Society |
| 2017 | Glasgow-Rubin Achievement Award for women graduating in top 10% of class, Columbia University College of Physicians and Surgeons |
| 2017 | Alpha Omega Alpha Society |
| 2017 | Robert F. Loeb Award for excellence in clinical medicine, Columbia University College of Physicians and Surgeons |
| 2016 | Knapp Scholarship for highest academic achievement in medical school, Columbia University College of Physicians and Surgeons |
| 2011 | Class of 1869 Prize in Ethics for academic work in philosophy, Princeton University |
| 2007 | United States Presidential Scholar, United States Department of Education |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2022. Keynote Speech. MDACC Medical Student Symposium. Houston, Texas, US.
- 2022. Ethics and Moral Distress in Radiation Oncology. Boston, Massachusetts, US.
- 2019. Shared Decision-Making in End-of-Life Care.
- 2016. Ethics and Radiation Oncology Grand Rounds. New York, New York, US.
- 2016. Moral Distress in Caring for Older Adults During Early Clinical Training. New York, New York, US.
National Presentations
- 2026. Management of Recurrent Brain Metastases. Invited. Network in Radiation Oncology. Houston, Texas, US.
- 2025. Informed Refusal. Invited. American Society of Radiation Oncology Annual Meeting. San Francisco, California, US.
- 2025. Multidisciplinary Tumor Board: High Grade Gliomas. Panelist. Society for Brain Mapping and Therapeutics Annual Meeting. Los Angeles, California, US.
- 2024. Challenging Cases in Palliative Care: Radioresistant Spinal Metastases. Invited. American Society of Radiation Oncology Annual Meeting. Washington, D.C, US.
- 2024. Clinical Trials in Radiation Oncology: Navigating Retreatment for Patients with Recurrent Brain Metastases. Invited. Society for Brain Mapping and Therapeutics Annual Meeting. Los Angeles, California, US.
- 2023. Challenging Cases in Palliative Care: Leptomeningeal Disease. Invited. American Society of Radiation Oncology Annual Meeting. San Diego, CA, US.
- 2023. Materializing Mourning: Reading and Writing about Grief. Invited. American Society of Radiation Oncology. San Diego, CA, US.
- 2023. Medical School and Beyond. Invited. Remote.
- 2022. Knowledge and Understanding of Treatment Options among Patients with Gastrointestinal (GI) Cancer in an Academic Cancer Center. Poster. American Society of Radiation Oncology Annual Meeting. San Antonio, TX, US.
- 2022. Informed Consent Considerations for Clinical and Research Use of AI Technologies. Invited. American Society of Radiation Oncology Annual Meeting. San Antonio, TX, US.
- 2022. Transparency and Representation in Clinical Research Using Artificial Intelligence in Oncology: A Scoping Review. Poster. ASCO Quality Symposium. Chicago, IL, US.
- 2021. Illness Perceptions, Financial Toxicity, Symptom Burden, and Survival in Cancer Clinical Trial Participants. Conference. ASCO Quality Symposium. Boston, MA, US.
- 2021. Using the Dosimetric Radiation Plan as a Teaching Tool for Early Trainees to Understand Radiation Toxicity. Conference. Radiation Oncology Education Collaborative Study Group Meeting, US.
- 2021. The Human Factor: Supporting Patient-centered Decision-making in Oncology. Columbus, Ohio, US.
- 2021. Association of a Deep Learning Estimation of Chest Imaging Age with Survival in Patients with Non-Small Cell Lung Cancers Undergoing Radiation. Conference. American Society of Radiation Oncology Annual Meeting, US.
- 2021. The Human Factor: Supporting Patient-centered Decision-making in Oncology. New York, New York, US.
- 2021. The Human Factor: Supporting Patient-centered Decision-making in Oncology. Dallas, Texas, US.
- 2020. Predictors of 30-day Mortality Following Palliative Radiation. Conference. American Society of Radiation Oncology Annual Meeting. Miami, FL, US.
- 2019. Local Therapy for a Systemic Disease: Indications and Impact of Radiation Therapy to Pancreatic Primary in Metastatic Pancreatic Cancer. Conference. American Society of Radiation Oncology Annual Meeting. Chicago, IL, US.
- 2017. Moral Relevance of Uncertainty in Medical Decision-Making. Invited. Fellowship at Auschwitz for Study of Professional Ethics Symposium. New York, NY, US.
- 2016. Efficacy and Tolerability of Neoadjuvant Stereotactic Body Radiotherapy and Intensity Modulated Radiation Therapy for “Unresectable” Pancreatic Cancer. Conference. American Society of Radiation Oncology Annual Meeting. Boston, MA, US.
- 2016. Clinical Outcomes of Stereotactic Body Radiation for Pancreatic Adenocarcinoma in the Elderly. Conference. American Geriatrics Society Meeting. Long Beach, CA, US.
- 2016. Development of a Predictive Quantitative Contrast CT-Based Feature (Radiomics) Profile for Local Recurrence in Oropharyngeal Cancers. Conference. American Society of Radiation Oncology Annual Meeting. Boston, MA, US.
- 2016. Feasibility of Vascular Matching for Pancreatic Stereotactic Body Radiotherapy. Conference. Radiological Society of North America Annual Meeting. Chicago, IL, US.
- 2016. Gender Differences in Time to Promotion and Scholarly Activity among Academic Radiation Oncologists. Conference. American Radium Society Meeting. Philadelphia, PA, US.
- 2010. Functional Analysis of a p53 Isoform, Δ133p53. Conference. National Institutes of Health. Bethesda, MD, US.
- 2010. Cultural Variance in Autonomous Medical Decision-Making. Invited. Gold Foundation. Chicago, IL, US.
- 2009. Targeting DNA Repair in Triple-Negative Breast Cancer. Conference. National Institutes of Health. Bethesda, MD, US.
International Presentations
- 2025. Multidisciplinary management of brain metastases. Invited. Clinica Alemana CNS Oncology Symposium. Santiago, CL.
- 2025. Advances in Radiotherapy for Brain Metastases: New Evidence and Ongoing Trials. Invited. Santiago, CL.
- 2024. Predictors of Early Local Failure in Patients Undergoing Resection of Locally Recurrent Brain Metastases Post-Radiosurgery. Conference. Gilbert Fletcher Society Meeting. Istanbul, TR.
- 2024. Artificial Intelligence and Clinical Trials. Remote.
Formal Peers
- 2015. Borderline Resectable Pancreatic Cancer: Current Controversies. Visiting. New York, NY, US.
- 2012. Emergency Department – Primary Care Connect Program Results. Visiting. Silver Spring, MD, US.
Grant & Contract Support
| Date: | 2026 - Present |
| Title: | Evaluation of the association between nanomechanical signature and response of brain metastases to high dose stereotactic radiosurgery |
| Funding Source: | ARTIDIS |
| Role: | PI |
| Date: | 2026 - Present |
| Title: | Establishment of an Integrated LITT Research Platform for Primary and Metastatic Brain Tumors at MD Anderson |
| Funding Source: | Marnie Rose Foundation |
| Role: | Co-PI |
| Date: | 2026 - Present |
| Title: | CNS-directed HER2-targeted therapy and Adaptive Radiation Treatment (CHART): A multi-cohort exploratory phase II trial in gastroesophageal cancer |
| Funding Source: | Gateway Foundation |
| Role: | PI |
| Date: | 2016 - 2017 |
| Title: | Moral distress in caring for older adults in early clinical training |
| Funding Source: | Steve P. Miller Foundation Grant for Humanism in Medical Education |
| Role: | PI |
| Date: | 2016 - 2017 |
| Title: | Effects of SBRT on immune response to pancreatic adenocarcinoma |
| Funding Source: | American Medical Association |
| Role: | PI |
| Date: | 2015 - 2017 |
| Title: | Cultural variance in defining autonomous medical decision-making |
| Funding Source: | Arnold P. Gold Foundation |
| Role: | PI |
| Date: | 2015 - 2016 |
| Title: | Stereotactic body radiotherapy for pancreatic cancer |
| Funding Source: | Columbia Medical Student Research Grant |
| Role: | Co-I |
Selected Publications
Peer-Reviewed Articles
- Carriere, P, Haisraely, O, Aaroe, AE, Ahmed, K, Lewis, R, Colson-Fearon, D, Bolden, M, Swanson, T, Beckham, TH, Wang, C, De, BS, Perni, S, Tom, MC, Li, J, McGovern, SL, McAleer, MF, Ghia, AJ, Jiang, W, Chung, C, Grosshans, DR, Ballester, L, Esquenazi, Y, Kamiya Matsuoka, C, Yeboa, DN. Long-term outcomes in IDH-wildtype (IDH-wt) gliomas with historical WHO grade 2 and 3 histology. Journal of neuro-oncology 179(1), 2026. e-Pub 2026. PMID: 42489814.
- Call-Orellana, F, Zuluaga-Garcia, JP, de Almeida, R, Beck, A, Beckham, TH, Ghia, AJ, Li, J, Tom, MC, McAleer, MF, Perni, S, Wang, C, Yeboa, DN, Cross, KA, Alvarez-Breckenridge, C, Kimchi, G, Rhines, LD, Tatsui, CE, North, RY. Applicability of RECIST1.1, MDACC and SPINO Tumor Response Criteria After Adjuvant Stereotactic Spinal Radiosurgery in Surgically Treated Spinal Metastases. Medicina (Lithuania) 62(7), 2026. e-Pub 2026. PMID: 42512796.
- Kienhöfer, M, Chi, X, Bhat, S, Campbell, E, Wathoo, C, Gubbiotti, M, Perni, S, Puduvalli, VK, Lin, R, Majd, NK. Genomic determinants of radiation necrosis in diffuse glioma patients. Journal of Clinical Oncology 44:2053, 2026. e-Pub 2026.
- Haisraely, O, Tom, MC, Perni, S, Kudchadker, RJ, Prajapati, S, Zlateva, Y, Weinberg, JS, Yeboa, DN, Li, J, Ferguson, SD, Alvarez-Breckenridge, C, Patel, CB, Ene, CI, Prabhu, S, Beckham, TH. Cs-131 Collagen Tile Brachytherapy for Recurrent Glioblastoma. Practical radiation oncology 16(2):e101-e107, 2026. e-Pub 2026. PMID: 41360286.
- Beckham, TH, Dudzinski, SO, Rooney, M, Faraj, CA, Pasli, M, Perni, S, Tom, MC, Ghia, AJ, Yeboa, DN, McAleer, MF, Swanson, T, McGovern, SL, Wang, C, Chung, C, De, BS, Jiang, W, Kim, BY, Ferguson, SD, Tawbi, H, Glitza, I, Le, X, Kaya, D, Dumbrava, EE, Briere, TM, Mackin, DS, Li, J. Incorporating an NCCN-Based Systemic Therapy CNS Activity Score Into SRS Decision-Making for Patients With 5 or More Brain Metastases. JNCCN Journal of the National Comprehensive Cancer Network 24(2):34-40, 2026. e-Pub 2026. PMID: 41671425.
- Kleber, T, Milton, D, Srinivasan, S, Panthi, B, Floyd, W, Goethe, E, Davies, MA, Tawbi, H, Glitza, IC, Kaya, D, Li, J, Swanson, T, Perni, S, Tom, MC, Wang, C, Prabhu, SS, Weinberg, J, McCutcheon, IE, Chung, C, Ferguson, SD, Beckham, TH. Outcomes of patients with melanoma brain metastases treated with ipilimumab and nivolumab with or without upfront comprehensive stereotactic radiosurgery. Neuro-Oncology Advances 8(1), 2026. e-Pub 2026. PMID: 41664820.
- Yeboa, DN, Whitfield, BT, Lin, R, Ejezie, CL, Swanson, T, Beckham, TH, Wang, C, De, BS, Perni, S, Tom, MC, Li, J, McGovern, SL, Harrison, R, Majd, NK, Puduvalli, VK, Aaroe, AE, Loghin, ME, O'Brien, BJ, Patel, AD, Patel, C, Wefel, JS, Taslicay, CA, Gule-Monroe, MK, Paulino, AC, McAleer, MF, Grosshans, DR, Ghia, AJ, Jiang, W, Chung, C, Maor, MM, Yang, CH, Gubbiotti, M, Kamiya Matsuoka, C, Ballester, L, Weathers, S, Huse, J. Prospective phase II clinical trial of molecular glioblastoma (historical grade 2 and 3 IDH wildtype gliomas) preliminary novel exploratory analyses. Journal of neuro-oncology 176(1), 2026. e-Pub 2026. PMID: 41191157.
- Haisraely O, Vedala S, Al-Sharfeen A, Manzar GS, Perni S, Tom MC, Beckham TH, Wang C, Yeboa DN, Chung C, McAleer MF, Ghia AJ, Ene CI, Weathers SP, McGovern SL, Wogan CF, Roth M, Li J, De B. Glioblastoma in young adult patients: contemporary patterns of care and survival in the United States. J Neurooncol 175(1):323-331, 2025. e-Pub 2025. PMID: 40663309.
- Ghia AJ, Guha-Thakurta N, Munsell MF, Briere TM, Wang C, Beckham TH, Yeboa D, Tom MC, Perni S, Li J, McAleer M, Chang EL, North RY, Alvarez-Breckinridge C, Tatsui CE, Brown PD, Rhines LD. Long-term results from a Phase 1 study of spinal cord constraint relaxation with single session spine stereotactic radiosurgery in the primary management of patients with inoperable, previously unirradiated spinal metastases with epidural extension. Int J Radiat Oncol Biol Phys 124(5):1219-1225, 2025. e-Pub 2025. PMID: 40614786.
- Rhee DJ, Perni S, Perrin KJ, Casey KE, Leone AO, Nguyen CM, Court LE, Wang H, Wang X, Han EY. Semi-automated hippocampal avoidance whole-brain radiotherapy planning. J Appl Clin Med Phys 26(7):e70076, 2025. e-Pub 2025. PMID: 40653628.
- Beckham TH, Cha EE, Rooney MK, Tom MC, Perni S, McAleer MF, Li J, Kudchadker RJ, Prajapati S, Zlateva Y, Kaya D, Ene CI, Ferguson SD, Huse JT, Prabhu SS, Weinberg JS. Cesium-131 collagen tile brachytherapy for salvage of recurrent intracranial metastases. J Neurooncol 175(1):165-174, 2025. e-Pub 2025. PMID: 40549120.
- Goethe EA, Andrade de Almeida RA, Call-Orellana F, Mikula AL, Clarke MJ, Merrell KW, Rose PS, Karim SM, Linzey JR, Szerlip NJ, Amini B, Beckham TH, Ghia AJ, Li J, Tom MC, McAleer MF, Perni S, Wang C, Yeboa DN, Price A, Alvarez-Breckenridge C, Rhines LD, Tatsui CE, North RY. Sacral fracture risk after stereotactic spinal radiosurgery: a multi-institution, retrospective analysis. J Neurosurg Spine 43(3):305-312, 2025. e-Pub 2025. PMID: 40540799.
- Yeboa DN, Li J, Lin R, Prabhu SS, Beckham TH, Woodhouse K, Swanson TA, Weinberg JS, Wang X, Chi X, Ejezie CL, Suki D, Wang C, Ene C, McCutcheon IE, McGovern S, McAleer MF, Tom M, Ghia A, Perni S, Jiang W, De B, Chung C, Kim BYS, O'Brien BJ, Huse JT, Wefel JS, Court L, Tawbi H, Janku F, Guha-Thakurta N, Debnam JM, Johnson J, Taslicay CA, Alvarez-Breckenridge C, Raza SM, Heimberger AB, DeMonte F, North R, Briere TM, de Groot JF, Sawaya R, Grosshans D, Lang FF, Rao G, Ferguson SD. Therapy, Safety, and Logistics of Preoperative vs Postoperative Stereotactic Radiation Therapy: A Preliminary Analysis of a Randomized Clinical Trial. JAMA Oncol 11(8):890-899, 2025. e-Pub 2025. PMID: 40531511.
- Bontempi, D, Zalay, O, Bitterman, DS, Birkbak, NJ, Shyr, D, Haugg, F, Qian, JM, Roberts, H, Perni, S, Prudente, V, Pai, S, Dekker, AL, Haibe-Kains, B, Guthier, CV, Balboni, TA, Warren, L, Krishan, M, Kann, BH, Swanton, C, De Ruysscher, D, Mak, RH, Aerts, HJ. FaceAge, a deep learning system to estimate biological age from face photographs to improve prognostication. The Lancet Digital Health 7(6), 2025. e-Pub 2025. PMID: 40345937.
- Faraj CA, McCutcheon IE, Gubbiotti MA, Perni S, Gule-Monroe MK, Akdemir K, Clark VE, Bander ED, Loghin ME, Prabhu SS, Lang FF, Weinberg JS. Extra-central nervous system metastasis from high-grade glioma: a single-institution experience. J Neurooncol 173(1):193-204, 2025. e-Pub 2025. PMID: 40055259.
- Koutroumpakis, E, Naser, M, Mohamed, AS, Eraj, SA, Jarre, A, Shiao, J, Kamal Jomaa, M, Perni, S, Phan, J, Morrison, WH, Frank, SJ, Gunn, GB, Garden, AS, Deswal, A, Abe, J, Rosenthal, D, Mouhayar, E, Fuller, C. Detection of alteration in carotid artery volumetry using standard-of-care computed tomography surveillance scans following unilateral radiation therapy for early-stage tonsillar squamous cell carcinoma survivors. Clinical and Translational Radiation Oncology 51, 2025. e-Pub 2025. PMID: 39867727.
- Matsui JK, Swanson D, Allen P, Perlow HK, Bradshaw J, Beckham TH, Tom MC, Wang C, Perni S, Yeboa DN, Ghia AJ, McAleer MF, Li J, Palmer JD, McGovern SL. Reduced Treatment Volumes for Glioblastoma Associated With Lower Rates of Radionecrosis and Lymphopenia: A Pooled Analysis. Adv Radiat Oncol 10(3):101717, 2025. e-Pub 2025. PMID: 40028224.
- Koutroumpakis E, Naser MA, Radwan Mohamed AS, Eraj SA, Jarre A, Shiao JC, Kamal M, Perni S, Phan JP, Morrison WH, Frank SJ, Gunn GB, Garden AS, Deswal A, Abe JI, Rosenthal DI, Mouhayar E, Fuller CD. Detection of alteration in carotid artery volumetry using standard-of-care computed tomography surveillance scans following unilateral radiation therapy for early-stage tonsillar squamous cell carcinoma survivors: a cross-sectional internally-matched carotid isodose analysis. Clin Transl Radiat Oncol 51:100912, 2025. e-Pub 2025. PMID: 39867727.
- Tom MC, Komatineni S, Wang C, de Almeida RAA, Ghia AJ, Beckham TH, Perni S, McAleer MF, Swanson T, Yeboa DN, De BS, Rooney MK, Bishop AJ, Reddy JP, Yang Y, Ludmir EB, Zhang S, Amini B, Alvarez-Breckenridge C, North RY, Rhines LD, Li J, Tatsui CE. Spinal laser interstitial thermal therapy and radiotherapy for thoracic metastatic epidural spinal cord compression. J Neurooncol 170(2):289-296, 2024. e-Pub 2024. PMID: 39325339.
- Beckham TH, Rooney MK, Cifter G, Bernard V, McAleer MF, De BS, Tom MC, Perni S, Wang C, Swanson T, Tatsui CE, Alvarez-Breckenridge C, North R, Rhines LD, Tang C, Logothetis C, Amini B, Li J, Yeboa DN, Ghia AJ. Stereotactic Radiosurgery for Prostate Cancer Spine Metastases: Local Control and Fracture Risk Using a Simultaneous Integrated Boost Approach. J Neurosurg Spine 41(3):436-444, 2024. e-Pub 2024. PMID: 38875722.
- Chen JJ, Brown AM, Garda AE, Kim E, McAvoy SA, Perni S, Rooney MK, Shiue K, Tonning KL, Warren LE, Golden DW, Croke JM, Working Group ROECSGPE. Patient Education Practices and Preferences of Radiation Oncologists and Interprofessional Radiation Therapy Care Teams: A Mixed-Methods Study Exploring Strategies for Effective Patient Education Delivery. Int J Radiat Oncol Biol Phys 119(5):1357-1367, 2024. e-Pub 2024. PMID: 38437924.
- Beckham TH, Rooney MK, McAleer MF, Ghia AJ, Tom MC, Perni S, McGovern S, Grosshans D, Chung C, Wang C, De B, Swanson T, Paulino A, Jiang W, Ferguson S, Patel CB, Li J, Yeboa DN. Hypofractionated radiotherapy for glioblastoma: A large institutional retrospective assessment of 2 approaches. Neurooncol Pract 11(3):266-274, 2024. e-Pub 2024. PMID: 38737610.
- Beckham, TH, Dudzinski, SO, Pasli, M, Perni, S, Tom, MC, Ghia, AJ, Yeboa, DN, McAleer, MF, Swanson, T, McGovern, SL, Wang, C, Chung, C, Briere, TM, An, R, De, BS, Glitza, IC, Kim, YB, McCutcheon, IE, Ferguson, SD, Li, J. Radiosurgery to 5 or more newly diagnosed brain metastases in the systemic therapy era. Journal of Clinical Oncology 42(16):2026, 2024. e-Pub 2024.
- Koutroumpakis E, Naser MA, Mohamed ASR, Eraj SA, Jarre A, Shiao JC, Kamal M, Perni S, Phan JP, Morrison WH, Frank SJ, Gunn GB, Garden AS, Deswal A, Abe JI, Rosenthal DI, Mouhayar E, Fuller CD. Detection of Alteration in Carotid Artery Volumetry Using Standard-of-care Computed Tomography Surveillance Scans Following Unilateral Radiation Therapy for Early-stage Tonsillar Squamous Cell Carcinoma Survivors: A Cross-Sectional Internally-Matched Carotid Isodose Analysis. medRxiv, 2024. e-Pub 2024. PMID: 38798400.
- Wang C, Rooney MK, Alvarez-Breckenridge C, Beckham TH, Chung C, De BS, Ghia AJ, Grosshans D, Majd NK, McAleer MF, McGovern SL, North RY, Paulino AC, Perni S, Reddy JP, Rhines LD, Swanson TA, Tatsui CE, Tom MC, Yeboa DN, Li J. Outcomes and Pattern of Care for Spinal Myxopapillary Ependymoma in the Modern Era-A Population-Based Observational Study. Cancers (Basel) 16(11), 2024. e-Pub 2024. PMID: 38893133.
- Ene CI, Abi Faraj C, Beckham TH, Weinberg JS, Andersen CR, Haider AS, Rao G, Ferguson SD, Alvarez-Brenkenridge CA, Kim BYS, Heimberger AB, McCutcheon IE, Prabhu SS, Wang CM, Ghia AJ, McGovern SL, Chung C, McAleer MF, Tom MC, Perni S, Swanson TA, Yeboa DN, Briere TM, Huse JT, Fuller GN, Lang FF, Li J, Suki D, Sawaya RE. Response of Treatment-Naive Brain Metastases to Stereotactic Radiosurgery. Nat Commun 15(1):3728, 2024. e-Pub 2024. PMID: 38697991.
- Gomez GT, Turner BE, Redmond KJ, Deville C, Perni S. Neuro-oncology clinical trial locations and social vulnerability in the United States. Neurooncol Pract 11(1):100-102, 2024. e-Pub 2024. PMID: 38222050.
- Cho HL, Balboni T, Christ SM, Turner B, Spektor A, Perni S. Is oligometastatic cancer curable?: a survey of oncologist perspectives, decision-making, and communication. Adv Radiat Oncol 8(5):101221, 2023. e-Pub 2023. PMID: 37124028.
- Zalay O, Bontempi D, Bitterman DS, Birkbak N, Shyr D, Haugg F, Qian JM, Roberts H, Perni S, Prudente V, Pai S, Dekker A, Haibe-Kains B, Guthier C, Balboni T, Warren L, Krishan M, Kann BH, Swanton C, Ruysscher D, Mak RH, Aerts HJ. Decoding biological age from face photographs using deep learning. medRxiv, 2023. e-Pub 2023. PMID: 37745558.
- Hosny, A, Bitterman, DS, Guthier, CV, Qian, JM, Roberts, H, Perni, S, Saraf, A, Peng, LC, Pashtan, I, Ye, Z, Kann, BH, Kozono, D, Christiani, DC, Catalano, PJ, Aerts, HJ, Mak, RH. Clinical validation of deep learning algorithms for radiotherapy targeting of non-small-cell lung cancer. The Lancet Digital Health 4(9):e657-e666, 2022. e-Pub 2022. PMID: 36028289.
- Perni, S, Azoba, C, Gorton, E, Park, ER, Chabner, BA, Moy, B, Nipp, RD. Financial Toxicity, Symptom Burden, Illness Perceptions, and Communication Confidence in Cancer Clinical Trial Participants. JCO Oncology Practice 109, 2022. e-Pub 2022. PMID: 35666957.
- Gartrell RD, Enzler T, Kim PS, Fullerton BT, Fazlollahi L, Chen AX, Minns HE, Perni S, Weisberg SP, Rizk EM, Wang S, Oh EJ, Guo XV, Chiuzan C, Manji GA, Bates SE, Chabot J, Schrope B, Kluger M, Emond J, Rabadán R, Farber D, Remotti HE, Horowitz DP, Saenger YM. Neoadjuvant chemoradiation alters the immune microenvironment in pancreatic ductal adenocarcinoma. Oncoimmunology 11(1):2066767, 2022. e-Pub 2022. PMID: 35558160.
- Perni, S, Bitterman, DS, Ryan, J, Silver, JK, Mitchell, E, Christensen, S, Daniels, M, Bloom, M, Hochberg, EP, Ryan, DP, Haas-Kogan, D, Loeffler, JS, Tarbell, N, Parikh, AR, Wo, JY. Gender, Productivity, and Philanthropic Fundraising in Academic Oncology. JNCCN Journal of the National Comprehensive Cancer Network 19(12):1401-1406, 2021. e-Pub 2021. PMID: 34902830.
- Perni, S, Moy, B, Nipp, RD. Disparities in phase 1 cancer clinical trial enrollment. Cancer 127(23):4464-4469, 2021. e-Pub 2021. PMID: 34379799.
- Perni, S, Saraf, A, Milligan, MG. The Resident Room. Practical radiation oncology 11(3):e252-e253, 2021. e-Pub 2021. PMID: 33676033.
- Perni, S, Saraf, A, Milligan, MG, Oladeru, OT, Franco, I, Elmore, SN. A Paradigm Shift in Radiation Oncology Training. Advances in Radiation Oncology 6(2), 2021. e-Pub 2021. PMID: 33732957.
- Rooney MK, Santiago G, Perni S, Horowitz DP, McCall AR, Einstein AJ, Jagsi R, Golden DW. Readability of Patient Education Materials From High-Impact Medical Journals: A 20-Year Analysis. J Patient Exp 8:2374373521998847, 2021. e-Pub 2021. PMID: 34179407.
- Burns, ZT, Bitterman, DS, Perni, S, Boyle, PJ, Guss, CE, Haas-Kogan, D, Liu, KX. Clinical Characteristics, Experiences, and Outcomes of Transgender Patients with Cancer. JAMA Oncology 7(1), 2021. e-Pub 2021. PMID: 33180096.
- Perni S, Milligan MG, Saraf A, Vivenzio T, Marques A, Baker MA, Kosak T, Bartlett S, Physic MA, Batcheldere MR, McBride S, Breedfeldt J, Cail DW, Kearney MC, Whitehouse C, Orio P, Walsh G, Haas-Kogan DA, Martin NE. Treating the SARS-CoV-2-positive cancer patient: a proposal for a pragmatic and transparent ethical process. Cancer, 2020. e-Pub 2020.
- Sha ST, Perni S, Muralidhar V, Mahal BA, Sanford NN, Nguyen PL, Dee EC. Trends, quality, and readability of online health resources on proton radiation therapy. International Journal of Radiation Oncology * Biology * Physics, 2020. e-Pub 2020.
- Perni S, Pollack LR, Gonzalez WC, Dzeng E, Baldwin MR. Moral distress and burnout in caring for older adults during medical school training. BMC Medical Education, 2020. e-Pub 2020.
- Perni S, Rooney M, Horowitz DP, Golden DW, McCall AR, Einstein AJ, Jagsi R. Written clinical informed consent for patients with cancer undergoing radiotherapy: a nationwide survey and readability analysis. JAMA Oncology, 2019. e-Pub 2019.
- Elhalawani H, Lin TA, Volpe S, Mohamed ASR, White AL, Zafereo J, Wong AJ, Berends JE, AboHashem S, Williams B, Aymard JM, Kanwar A, Perni S, Rock CD, Cooksey L, Campbell S, Yang P, Nguyen K, Ger RB, Cardenas CE, Fave XJ, Sansone C, Piantadosi G, Marrone S, Liu R, Huang C, Yu K, Li T, Yu Y, Zhang Y, Zhu H, Morris JS, Baladandayuthapani V, Shumway JW, September D, Perni Ghosh A, Pöhlmann A, Phoulady HA, Goyal V, Canahuate G, Marai GE, Vock D, Lai SY, Mackin DS, Court LE, Freymann J, Farahani K, Kaplathy-Cramer J, Fuller CD. Machine learning applications in head and neck radiation oncology: lessons from open-source radiomics challenges. Frontiers in Oncology, 2018. e-Pub 2018.
- Elhalwani H, Kanwar A, Mohamed ASR, White A, Zafereo J, Wong A, Berends J, Abohashem S, Williams B, Aymard JM, Perni S, Messer J, Warren B, Youssef B, Yang P, Meheissen MAM, Kamal M, Elgohari B, Ger RB, Cardenas CE, Fave X, Zhang L, Mackin D, Marai GE, Vock DM, Canahuate GM, Lai SY, Gunn GB, Garden AS, Rosenthal DI, Court L, Fuller CD. Investigation of radiomics based signature for local recurrence using primary tumor texture analysis in oropharyngeal head and neck cancer patients. Scientific Reports, 2018. e-Pub 2018.
- Elhalawani H, Lin TA, Volpe S, Mohamed ASR, White AL, Zafereo J, Wong AJ, Berends JE, AboHashem S, Williams B, Aymard JM, Kanwar A, Perni S, Rock CD, Cooksey L, Campbell S, Yang P, Nguyen K, Ger RB, Cardenas CE, Fave XJ, Sansone C, Piantadosi G, Marrone S, Liu R, Huang C, Yu K, Li T, Yu Y, Zhang Y, Zhu H, Morris JS, Baladandayuthapani V, Shumway JW, Ghosh A, Pohlmann A, Phoulady HA, Goyal V, Canahuate G, Marai GE, Vock D, Lai SY, Mackin DS, Court LE, Freymann J, Farahani K, Kaplathy-Cramer J, Fuller CD. Machine Learning Applications in Head and Neck Radiation Oncology: Lessons From Open-Source Radiomics Challenges. Front Oncol 8:294, 2018. e-Pub 2018. PMID: 30175071.
- Elhalwani H, Mohamed ASR, White AL, Zafereo J, Wong AJ, Berends JE, AboHashem S, Williams B, Aymard JM, Kanwar A, Perni S, Rock CD, Cooksey L, Campbell S, Ding Y, Lai SY, Marai EG, Vock D, Canahuate GM, Freymann J, Farahani K, Kalpathy-Cramer J, Fuller CD. Matched computed tomography segmentation and demographic data for oropharyngeal radiomics challenges. Nature Scientific Data, 2017. e-Pub 2017.
- Perni S, Wang TJ, Lesser J, Mandigo C, Isaacson SR, Horowitz DP. Gamma knife treatment of recurrent CNS metastases of pancreatic origin: a case report and review of the literature. CNS Oncology, 2017. e-Pub 2017.
- Perni S, Mohamed AS, Scott J, Enderling H, Garden AS, Gunn GB, Rosenthal DI, Fuller CD. CT-based volumetric tumor growth velocity: A novel imaging prognostic indicator in oropharyngeal cancer patients receiving radiotherapy. Oral Oncol 63:16-22, 2016. e-Pub 2016. PMID: 27938995.
- Perni S, Kim SK, Chin C, Pfister NT, Tiwari A, Horowitz DP. Radiotherapy for right-sided breast cancer in a patient with pectus excavatum: a comparison of treatment techniques. Practical Radiation Oncology, 2016. e-Pub 2016.
- Beckham TH, Rooney MK, McAleer MF, Ghia AJ, Tom M, Perni S, McGovern S, Grosshans D, Chung C, Wang C, Swanson T, Paulino A, Jiang W, Ferguson S, Patel C, Li J, Yeboa DN. Hypofractionated radiotherapy for glioblastoma multiforme: a large institutional retrospective experience of two approaches. Journal of Neuro-Oncology.
- Koutroumpakis E, Naser MA, Radwan Mohamed AS, Eraj SA, Jarre A, Shiao JC, Kanwar A, Jomaa MK, Perni S, Phan JP, Morrison WH, Frank SJ, Gunn G, Garden AS, Deswal A, Abe J, Rosenthal DI, Mouhayar E, Fuller CD. Detection of Early Alteration in Regional Carotid Artery Volumetry Using Standard-of-care Computed Tomography Surveillance Scans Following Unilateral Radiation Therapy for Early-stage Tonsillar Squamous Cell Carcinoma Survivors: A Cross-Sectional Internal-Matched Carotid Isodose Analysis.”.
- Sanchez A, Aziz Z, Perni S, Kachnic LA, Horowitz DP. Sarcopenia is not a contraindication to chemoradiotherapy and surgery for patients with locally-advanced pancreatic ductal adenocarcinoma. Advances in Radiation Oncology.
- Zhao G, PhD, Han EY, PhD, Hancock D, BS, Perrin K, BS, Li J, MD, Ghia A, MD, Tom M, MD, Beckham T, MD, Wang C, MD, Perni S, MD, Wang X, PhD. Feasibility and advantages of using a single isocenter to treat two targets separated by one vertebra in spinal stereotactic radiosurgery and stereotactic body radiation therapy. JNS Spine.
Review Articles
- D'Amiano AJ, Cheunkarndee T, Azoba C, Chen KY, Mak RH, Perni S. Transparency and Representation in Clinical Research Utilizing Artificial Intelligence in Oncology: A Scoping Review. Cancer Med 14(5):e70728, 2025. e-Pub 2025. PMID: 40059400.
- Perni S, Jimenez R, Jagsi R. Optimizing informed consent in cancer clinical trials. Semin Radiat Oncol 33(4):349-357, 2023. e-Pub 2023. PMID: 37684064.
- Perni, S, Hong, K, Hong, TS, Nipp, RD. Toward a Science of Personalized Informed Consent in Cancer Clinical Trials. JCO Oncology Practice 17(11):655-661, 2021. e-Pub 2021. PMID: 33974444.
Professional Educational Materials
- Perni S, Jimenez R. Harvard Medical School Radiation Oncology Career Advising Guide, 2022.
Other Articles
- Orr, M, Tringale, KR, Perni, S Biology-Informed Target Delineation in High-Grade Gliomas—Balancing Precision and Preservation. JAMA Network Open 8(7), 2025. PMID: 40705337.
- Cho HL, Perni S, D'Amico AV, Yamoah K, Dee EC The imperative for clinical trial diversity: Perspectives in the context of prostate-specific membrane antigen-targeted imaging. Prostate Cancer Prostatic Dis 26(3):511-515, 2023. PMID: 36872319.
Editorials
- Milligan M, Saraf A, Perni S. Medical misinformation: trainees on the starting line of truth. Acad Med 97(7):943-944, 2022. PMID: 34469352.
- Franco I, Perni S, Wiley S, Drapek L. Equity in radiation oncology post-COVID: bridging the telemedicine gap. International Journal of Radiation Oncology*Biology*Physics, 2020.
- Oladeru OT, Perni S, Williams B. Improving care for the overlooked in oncology: incarcerated patients. Lancet Oncology, 2019.
- Perni S. Moral distress: a call to action. AMA Journal of Ethics, 2017.
Book Chapters
- Perni S, Elkins IB, Feldman J. Patient Perspectives. In: Eltorai, Baker, Wazer, Kim, eds. Translational Radiation Oncology. Elsevier, 2023.
- Cho HL, Perni S. Ethics and Review Boards. In: Eltorai, Baker, Wazer, Kim, eds. Translational Radiation Oncology. Elsevier, 2023.
- Perni S. Radiation Oncology. In: The Ultimate Medical School Rotation Guide. Springer, 2021.
- Perni S. Central Nervous System. In: Pocket Radiation Oncology: The MD Anderson Cancer Center Handbook of Radiation Oncology. 2nd. Wolters Kluwer, 2021.
Letters to the Editor
- Perni S, Lehmann LS, Bitterman DS. Patients should be informed when AI systems are used in clinical trials. Nat Med 29: 1890-1891, 2023.
Patient Reviews
CV information above last modified August 24, 2026