Sumit K. Subudhi, M.D., Ph.D.
Department of Genitourinary Medical Oncology, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Associate Professor, Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
Dr. Sumit Subudhi is a medical oncologist and immunologist whose research focuses on the mechanisms and pathways within the immune system that are responsible for tumor rejection and clinical benefit. Dr. Subudhi’s medical training began when he enrolled in the MD/PhD program at The University of Chicago Pritzker School of Medicine in 1998. Dr. Subudhi’s predoctoral studies included examining the role of B7-H1 (PD-L1), an immune checkpoint, in regulating T cell–mediated immune responses. He completed his PhD in 2004, his MD in 2007, his internal medicine residency at the New York-Presbyterian Hospital/Weill Cornell Medical Center in 2009, and his medical oncology fellowship at Memorial Sloan Kettering Cancer Center (MSKCC) in 2013. During his medical training, Dr. Subudhi became interested in the field of tumor immunology and subsequently completed a postdoctoral fellowship in Dr. James P. Allison’s laboratory at MSKCC. In Dr. Allison’s laboratory (now at MD Anderson), Dr. Subudhi began to examine the effects of targeting immune checkpoints (e.g., CTLA-4 and PD-1) in prostate cancer and continues to uncover the mechanisms that tumors use to evade the immune system. After completing his fellowship at MSKCC, Dr. Subudhi was appointed as an Advanced Scholar Instructor at MD Anderson Cancer Center in 2013, and more recently (2014) as an Assistant Professor in Genitourinary Medical Oncology. His focus is on investigating optimal combinations of immune checkpoint blockade-based therapies and on developing immunological biomarkers to predict treatment responses, with the hope of ultimately producing durable and even curative responses in patients with prostate cancer. Dr. Subudhi was awarded the Prostate Cancer Foundation Young Investigator Award in 2014 to pursue these studies. Dr. Subudhi has also been investigating the immunological differences between primary prostate cancer and the bone metastasis microenvironment
Education & Training
Degree-Granting Education
| 2007 | The University of Chicago, Pritzker School of Medicine, Chicago, Illinois, US, MD |
| 2004 | The University of Chicago, Division of Biological Sciences, Chicago, Illinois, US, Immunology, PhD |
| 1994 | The University of Pennsylvania, College of Arts and Sciences, Philadelphia, Pennsylvania, US, Biological Basis of Behavior, BA |
Postgraduate Training
| 2009-2013 | Clinical Fellowship, Medical Oncology Fellowship, Memorial Sloan-Kettering Cancer Center, New York, New York |
| 2007-2009 | Clinical Residency, Internal Medicine, New York Presbyterian Hospital-Weill Cornell Medical Center, New York, New York |
Board Certifications
| 2013 | American Board of Internal Medicine-Medical Oncology |
| 2010 | American Board of Internal Medicine-Internal Medicine |
Experience & Service
Academic Appointments
Assistant Professor, Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, 2014 - 2021
Advanced Scholar Instructor, Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2013 - 2014
Other Appointments/Responsibilities
Advisory Board Member, Regeneron, New York, NY, 2024 - 2024
Advisory Board Member, Macrogenics, Dallas, 2024 - 2024
Advisory Board Member, Merck, Detroit, 2023 - 2023
Advisory Board Member, Bristol-Myers Squibb, Maryland, 2023 - 2023
Advisory Board Member, Merck AZ US Prostate Cancer Team, Detroit, 2023 - 2023
Advisory Board Member, Regeneron, San Francisco, CA, 2023 - 2023
Advisory Board Member, Bristol-Myers Squibb, San Francisco, CA, 2023 - 2023
Advisory Board Member, Janssen, Virtual, 2022 - 2022
Advisory Board Member, Janssen, New Orleans, LA, 2022 - 2022
Advisory Board Member, Bayer, Virtual, 2021 - 2021
Advisory Board Member, Dendreon, Virtual, 2021 - 2021
Advisory Board Member, Astellas/Pfizer, Virtual, 2021 - 2021
TMB Advisory Board Member, Bristol-Myers Squibb, Virtual, 2021 - 2021
Advisory Board Member, Janssen, Virtual, 2021 - 2021
Advisory Board Member, Amgen, Virtual, 2020 - 2020
Advisory Board Leader, Dendreon, Houston, TX, 2019 - 2019
Advisory Board Leader, Dendreon, Miami, FL, 2019 - 2019
Advisory Board Member, Bristol-Myers Squibb, Barcelona, Spain, 2019 - 2019
Advisory Board Member, Amgen, Phoenix, AZ, 2019 - 2019
Advisory Board Member, Bayer, Raleigh, NC, 2019 - 2019
Advisory Board Member, Bayer, San Francisco, CA, 2019 - 2019
Advisory Board Leader, Dendreon, Pittsburg, PA, 2019 - 2019
Advisory Board Member, Janssen, Houston, TX, 2018 - 2018
Advisory Board Member, Compugen, Chicago, IL, 2018 - 2018
Advisory Board Member, Janssen, Chicago, IL, 2018 - 2018
Advisory Board Member, Compugen, Chicago, IL, 2017 - 2017
Advisory Board Member, Dendreon, Chicago, IL, 2016 - 2016
Advisory Board Member, Dendreon, Chicago, IL, 2015 - 2015
Advisory Board Member, Dendreon, Wichita, KS, 2015 - 2015
Institutional Committee Activities
Board Member, Cancer Patient Lab, 2024 - Present
Member, Hervolution Therapeutics ApS Scientific Advisory Board, 2024 - Present
Member, Alliance Committees on Immuno-Oncology, 2024 - Present
Member, Bristol-Myers Squibb/Immunotherapy (IMT) Alliance Joint Steering Committee, 2022 - Present
Member, Advisory Board, 2021 - 2021
Member, Amgen/Immunotherapy (IMT) Alliance Joint Steering Committee, 2021 - 2023
Departmental Representative, MD Anderson Cancer Center Faculty Senate, 2021 - Present
Member, Javelin Oncology Scientific Advisory Board, 2021 - 2023
Member, Apricity Health Scientific Advisory Board, 2021 - Present
Member, Kahr Medical, Safety Monitoring Committee for DSP107 Study (NCT04440735), 2020 - Present
Member, MD Anderson Cancer Center Department of Genitourinary Medical Oncology Clinical Research Group Advisory Council, 2020 - Present
Executive Committee Member, MD Anderson Cancer Center Institutional Immuno-Oncology (IO) Toxicity Initiative, 2020 - 2023
Member, Dendreon, Oncology Executive Steering Committee, 2020 - Present
Leader, Prostate Researching Translational Endpoints Correlated to Response (PORTER), 2019 - 2022
Executive Committee Member, MD Anderson Cancer Center Immunotherapy Platform, 2019 - 2023
Member, MD Anderson Cancer Center Immuno-Oncology (IO) Toxicity Initiative Working Group, 2019 - 2023
Chairperson, Drug Selection Committee, 2019 - 2022
Member, Safety Assessment Committee for PORTER clinical trials, 2019 - 2022
Member, Immunotherapy (IMT) Platform Alliance Joint Scientific Steering Committee, 2018 - 2024
Chairperson, Dendreon, Independent Data Monitoring Committee (IDMC) for ProVent Study (NCT03686683), 2018 - Present
Member, Immunotherapy (IMT) Platform Alliance Joint Scientific Steering Committee, 2017 - Present
Member, MD Anderson Cancer Center Immunotherapy (IMT) Platform Working Group, 2017 - Present
Collaborator, MD Anderson Cancer Center Prostate SPORE program, 2017 - Present
Member, MD Anderson Cancer Center Scientific Research Committee (SRC), 2016 - Present
Honors & Awards
| 2023 | Regeneron-PCF Special Challenge Award, Prostate Cancer Foundation |
| 2017 | Lloyd Family Clinical Oncology Scholar Award, V Foundation |
| 2014 | Young Investigator Award, Prostate Cancer Foundation |
| 2013 | Young Investigator Award, Stand Up To Cancer and Cancer Research Institute |
| 2013 | Advanced Scholar, UT MD Anderson Cancer Center |
| 2011 | NIH Loan Repayment Program, National Institutes of Health |
| 2011 | NIH Clinical Scholars Biomedical Research Training Program, National Institutes of Health |
| 2011 | ASCO Poster Discussion Session, American Society of Clinical Oncology |
| 2006 | Francis L. Lederer MD/PhD Scholars Research Grant, University of Chicago |
| 2004 | Doolittle - Harrison Travel Fellowship, University of Chicago |
| 2002 | Best Poster Presentation, University of Chicago |
| 2000 | Winner of Sixth Annual Medical Student Poster Competition, American Society of Internal Medicine |
| 2000 | NIH Pediatric Growth and Development Training Grant, National Institutes of Health |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Venkatesh N, Tidwell RS, Yu Y, Aparicio A, Zurita AJ, Subudhi SK, Siddiqui BA, Mukhida SS, Gregg JR, Corn PG, Koutroumpakis E, McQuade JL, Frigo DE, Pilie PG, Huff C, Logothetis CJ, Hahn AW. Body composition in recurrent prostate cancer and the role of steroidogenic genotype. Endocr Relat Cancer 31(12):None, 2024. PMID: 39324992.
- Siddiqui BA, Palaskas NL, Basu S, Dai Y, He Z, Yadav SS, Allison JP, Sheth RA, Tummala S, Buja M, Bhattacharjee MB, Iliescu C, Rawther-Karedath A, Deswal A, Wang L, Sharma P, Subudhi SK. Molecular pathways and cellular subsets associated with adverse clinical outcomes in overlapping immune-related myocarditis and myositis. Cancer Immunol Res 12(8):964-987, 2024. e-Pub 2024. PMID: 38768394.
- Hahn AW, Tidwell RS, Pilie PG, Yu Y, Liu J, Surasi DS, Titus M, Zhang J, Venkatesh N, Panaretakis T, Gregg JR, Zurita AJ, Siddiqui BA, Corn PG, Subudhi SK, Msaouel P, Koutroumpakis E, Huff CD, Aparicio A, McQuade JL, Frigo DE, Logothetis CJ. Body composition as a determinant of the therapeutic index with androgen signaling inhibition. Prostate Cancer Prostatic Dis. e-Pub 2024. PMID: 39019979.
- Jiang Y, Montierth MD, Yu K, Ji S, Guo S, Tran Q, Liu X, Shin SJ, Cao S, Li R, Tang Y, Lesluyes T, Kopetz S, Ajani J, Msaouel P, Subudhi SK, Aparicio A, Sharma P, Shen JP, Sood AK, Tarabichi M, Wang JR, Kimmel M, Loo PV, Zhu H, Wang W. Pan-cancer subclonal mutation analysis of 7,827 tumors predicts clinical outcome. bioRxiv, 2024. e-Pub 2024. PMID: 39005348.
- Aparicio AM, Tidwell RSS, Yadav SS, Chen JS, Zhang M, Liu J, Guo S, Pilié PG, Yu Y, Song X, Vundavilli H, Jindal S, Zhu K, Viscuse PV, Lebenthal JM, Hahn AW, Soundararajan R, Corn PG, Zurita-Saavedra A, Subudhi SK, Zhang J, Wang W, Huff C, Troncoso P, Allison JP, Sharma P, Logothetis CJ. A Modular Trial of Androgen Signaling Inhibitor Combinations Testing a Risk-Adapted Strategy in Patients with Metastatic Castration-Resistant Prostate Cancer. Clin Cancer Res 30(13):2751-2763, 2024. e-Pub 2024. PMID: 38683200.
- Anselmino N, Labanca E, Shepherd PDA, Dong J, Yang J, Song X, Nandakumar S, Kundra R, Lee C, Schultz N, Zhang J, Araujo JC, Aparicio AM, Subudhi SK, Corn PG, Pisters LL, Ward JF, Davis JW, Vazquez ES, Gueron G, Logothetis CJ, Futreal A, Troncoso P, Chen Y, Navone NM. Integrative molecular analyses of the MD Anderson prostate cancer patient-derived xenograft (MDA PCa PDX) series. Clin Cancer Res 30(10):2272-2285, 2024. e-Pub 2024. PMID: 38488813.
- Ghosh S, Padhi R, Sahu S, Meher M, Jain P, Subudhi SK, Vihari J, Samal A, Sahu AK. Use of inferior vena cava guided fluid therapy in the treatment of septic shock: A randomised controlled trial. J Infect Dev Ctries 18(1):75-81, 2024. e-Pub 2024. PMID: 38377091.
- Viscuse PV, Slack-Tidwell RS, Zhang M, Rohra P, Zhu K, San Lucas FA, Konnick E, Pilie PG, Siddiqui B, Logothetis CJ, Corn P, Subudhi SK, Pritchard CC, Soundararajan R, Aparicio A. Evaluation of the Aggressive-Variant Prostate Cancer Molecular Signature in Clinical Laboratory Improvement Amendments (CLIA) Environments. Cancers (Basel) 15(24), 2023. e-Pub 2023. PMID: 38136389.
- Hahn AW, Thoman W, Koutroumpakis E, Abdulla A, Subudhi SK, Aparicio A, Basen-Enngquist K, Logothetis CJ, Gilchrist SC. Cardiometabolic healthcare for men with prostate cancer: an MD Anderson Cancer Center experience. Cardiooncology 9(1):33, 2023. e-Pub 2023. PMID: 37705024.
- Antonarakis ES, Subudhi SK, Pieczonka CM, Karsh LI, Quinn DI, Hafron JM, Wilfehrt HM, Harmon M, Sheikh NA, Shore ND, Petrylak DP. Combination Treatment with Sipuleucel-T and Abiraterone Acetate or Enzalutamide for Metastatic Castration-Resistant Prostate Cancer: STAMP and STRIDE Trials. Clin Cancer Res 29(13):2426-2434, 2023. e-Pub 2023. PMID: 37058234.
- Siddiqui BA, Chapin BF, Jindal S, Duan F, Basu S, Yadav SS, Gu AD, Espejo AB, Kinder M, Pettaway CA, Ward JF, Tidwell RSS, Troncoso P, Corn PG, Logothetis CJ, Knoblauch R, Hutnick N, Gottardis M, Drake CG, Sharma P, Subudhi SK. Immune and pathologic responses in patients with localized prostate cancer who received daratumumab (anti-CD38) or edicotinib (CSF-1R inhibitor). J Immunother Cancer 11(3), 2023. PMID: 36948506.
- Drake, CG, Pachynski, RK, Subudhi, SK, McNeel, DG, Antonarakis, ES, Bauer, TM, Lauer, P, Brockstedt, D, Patricia, D, Wade, M, Zudaire, E, Bandyopadhyay, N, Parasrampuria, DA, Girgis, S, Mason, G, Knoblauch, RE, Stone, N, Infante, JR, Gottardis, MM, Fong, L. Safety and preliminary immunogenicity of JNJ-64041809, a live-attenuated, double-deleted Listeria monocytogenes-based immunotherapy, in metastatic castration-resistant prostate cancer. Prostate Cancer and Prostatic Diseases 25(2):219-228, 2022. PMID: 34257408.
- Spetsieris N, Boukovala M, Alafis I, Davis J, Zurita A, Wang X, Tu SM, Chapin BF, Aparicio A, Corn P, Wang J, Subudhi SK, Araujo J, Papadopoulos J, Pruitt L, Weldon JA, Logothetis CJ, Efstathiou E. Abiraterone acetate plus prednisone in non-metastatic biochemically recurrent castration-naïve prostate cancer. Eur J Cancer 157:259-267, 2021. e-Pub 2021. PMID: 34536949.
- Palaskas NL, Segura A, Lelenwa L, Siddiqui BA, Subudhi SK, Lopez-Mattei J, Durand JB, Deswal A, Zhao B, Buja LM, Iliescu C. Immune Checkpoint Inhibitor Myocarditis: Elucidating the spectrum of disease through endomyocardial biopsy. Eur J Heart Fail 23(10):1725-1735, 2021. e-Pub 2021. PMID: 34114291.
- Subudhi SK, Siddiqui BA, Aparicio AM, Yadav SS, Basu S, Chen H, Jindal S, Tidwell RSS, Varma A, Logothetis CJ, Allison JP, Corn PG, Sharma P. Combined CTLA-4 and PD-L1 blockade in patients with chemotherapy-naïve metastatic castration-resistant prostate cancer is associated with increased myeloid and neutrophil immune subsets in the bone microenvironment. J Immunother Cancer 9(10), 2021. PMID: 34663638.
- Msaouel P, Oromendia C, Siefker-Radtke AO, Tannir NM, Subudhi SK, Gao J, Wang Y, Siddiqui BA, Shah AY, Aparicio AM, Campbell MT, Zurita AJ, Shaw LK, Lopez LP, McCord H, Chakraborty SN, Perales J, Lu C, Van Alstine ML, Elashoff M, Logothetis C. Evaluation of Technology-Enabled Monitoring of Patient-Reported Outcomes to Detect and Treat Toxic Effects Linked to Immune Checkpoint Inhibitors. JAMA Netw Open 4(8):e2122998, 2021. e-Pub 2021. PMID: 34459906.
- Drake, Charles, Pachynski, Russell, Subudhi, Sumit, McNeel, Douglas, Antonarakis, Emmanuel, Bauer, Todd, Lauer, Peter, Brockstedt, Dirk, Patricia, Daniel, Wade, Mark, Zudaire, Enrique, Bandyopadhyah, Nibedita, Parasrampuria, Dolly, Girgis, Suzette, Mason, Gary, Knoblauch, Roland, Stone, Nicole, Infante, Jeffrey, Gottardis, Marco, Fong, Lawrence. Safety and preliminary immunogenicity of JNJ-64041809, a live-attenuated, double-deleted Listeria monocytogenes-based immunotherapy, in metastatic castration-resistant prostate cancer. Prostate Cancer and Prostatic Disease, 2021. PMID: None.
- Siddiqui BA, Gheeya JS, Goswamy R, Bathala TK, Surasi DS, Gao J, Shah A, Campbell MT, Msaouel P, Goswami S, Wang J, Zurita AJ, Jonasch E, Corn PG, Aparicio AM, Siefker-Radtke AO, Sharma P, Subudhi SK, Tannir N. Durable Responses in Patients with Genitourinary Cancers Following Immune Checkpoint Therapy Rechallenge after Moderate to Severe Immune-Related Adverse Events. J Immunother Cancer 9(7), 2021. PMID: 34326169.
- Nguyen H, Shah K, Waguespack SG, Hu MI, Habra MA, Cabanillas ME, Busaidy NL, Bassett R, Zhou S, Iyer PC, Simmons G, Kaya D, Pitteloud M, Subudhi SK, Diab A, Dadu R. Immune checkpoint inhibitor related hypophysitis: diagnostic criteria and recovery patterns. Endocr Relat Cancer 28(7):419-431, 2021. e-Pub 2021. PMID: 33890870.
- Vardaki I, Corn P, Gentile E, Song JH, Madan N, Hoang A, Parikh N, Guerra L, Lee YC, Lin SC, Yu G, Santos E, Melancon MP, Troncoso P, Navone N, Gallick GE, Efstathiou E, Subudhi SK, Lin SH, Logothetis CJ, Panaretakis T. Radium-223 Treatment Increases Immune Checkpoint Expression in Extracellular Vesicles from the Metastatic Prostate Cancer Bone Microenvironment. Clin Cancer Res 27(11):3253-3264, 2021. e-Pub 2021. PMID: 33753455.
- Chang KY, Chiang NJ, Wu SY, Yen CJ, Chen SH, Yeh YM, Li CF, Feng X, Wu K, Johnston A, Bomalaski JS, Wu BW, Gao J, Subudhi SK, Kaseb AO, Blando JM, Yadav SS, Szlosarek PW, Chen LT. Phase 1b Study of Pegylated Arginine Deiminase (ADI-PEG 20) plus Pembrolizumab in Advanced Solid Cancers OncoImmunology. OncoImmunology 10(1), 2021. PMID: 34290906.
- Sinha M, Zhang L, Subudhi S, Chen B, Marquez J, Liu EV, Allaire K, Cheung A, Ng S, Nguyen C, Friedlander TW, Aggarwal R, Spitzer M, Allison JP, Small EJ, Sharma P, Fong L. Pre-existing immune status associated with response to combination of sipuleucel-T and ipilimumab in patients with metastatic castration-resistant prostate cancer. J Immunother Cancer 9(5), 2021. PMID: 33986125.
- Spetsieris N, Boukovala M, Weldon JA, Tsikkinis A, Hoang A, Aparicio A, Tu SM, Araujo JC, Zurita AJ, Corn PG, Pagliaro L, Kim J, Wang J, Subudhi SK, Tannir NM, Logothetis CJ, Troncoso P, Wang X, Wen S, Efstathiou E. A Phase 2 Trial of Abiraterone Followed by Randomization to Addition of Dasatinib or Sunitinib in Men With Metastatic Castration-Resistant Prostate Cancer. Clinical Genitourinary Cancer 19(1):22-31, 2021. PMID: 32675015.
- Sharma P, Pachynski RK, Narayan V, Fléchon A, Gravis G, Galsky MD, Mahammedi H, Patnaik A, Subudhi SK, Ciprotti M, Simsek B, Saci A, Hu Y, Han GC, Fizazi K. Nivolumab Plus Ipilimumab for Metastatic Castration-Resistant Prostate Cancer: Preliminary Analysis of Patients in the CheckMate 650 Trial. Cancer Cell 38(4):489-499.e3, 2020. e-Pub 2020. PMID: 32916128.
- Kim ST, Murphy WA, Aparicio A, Subudhi SK. RS3PE Following Treatment With Combination of Hormonal Therapies Plus Ipilimumab in a Patient With Metastatic Prostate Cancer. Journal of Immunotherapy and Precision Oncology, 2020. PMID: None.
- Subudhi SK, Vence L, Zhao H, Blando J, Yadav SS, Xiong Q, Reuben A, Aparicio A, Corn PG, Chapin BF, Pisters LL, Troncoso P, Tidwell RS, Thall P, Wu CJ, Zhang J, Logothetis CL, Futreal A, Allison JP, Sharma P. Neoantigen responses, immune correlates, and favorable outcomes after ipilimumab treatment of patients with prostate cancer. Sci Transl Med 12(537), 2020. PMID: 32238575.
- Corn PG, Zhang M, Nogueras-Gonzalez GM, Xiao L, Zurita AJ, Subudhi SK, Tu SM, Aparicio AM, Coarfa C, Rajapakshe K, Huang S, Navone NM, Lin SH, Wang G, Ramachandran S, Titus MA, Panaretakis T, Gallick GE, Efstathiou E, Troncoso P, Logothetis C. A Phase II Study of Cabozantinib and Androgen Ablation in Patients with Hormone-Naïve Metastatic Prostate Cancer. Clin Cancer Res 26(5):990-999, 2020. e-Pub 2020. PMID: 31941830.
- Boukovala M, Spetsieris N, Weldon JA, Tsikkinis A, Hoang A, Aparicio A, Tu SM, Araujo JC, Zurita AJ, Corn PG, Pagliaro L, Kim J, Wang J, Subudhi SK, Tannir NM, Logothetis CJ, Troncoso P, Wen S, Efstathiou E. A candidate androgen signalling signature predictive of response to abiraterone acetate in men with metastatic castration-resistant prostate cancer. Eur J Cancer 127:67-75, 2020. e-Pub 2020. PMID: 31986451.
- Jiao S, Subudhi SK, Aparicio A, Ge Z, Guan B, Miura Y, Sharma P. Differences in Tumor Microenvironment Dictate T Helper Lineage Polarization and Response to Immune Checkpoint Therapy. Cell 179(5):1177-1190.e13, 2019. PMID: 31730856.
- Vence L, Bucktrout SL, Fernandez Curbelo I, Blando J, Smith BM, Mahne AE, Lin JC, Park T, Pascua E, Sai T, Chaparro-Riggers J, Subudhi SK, Scutti JB, Higa MG, Zhao H, Yadav SS, Maitra A, Wistuba II, Allison JP, Sharma P. Characterization and comparison of GITR expression in solid tumors. Clin Cancer Res 25(21):6501-6510, 2019. e-Pub 2019. PMID: 31358539.
- Tahir SA, Gao J, Miura Y, Blando J, Tidwell RSS, Zhao H, Subudhi SK, Tawbi H, Keung E, Wargo J, Allison JP, Sharma P. Autoimmune antibodies correlate with immune checkpoint therapy-induced toxicities. Proc Natl Acad Sci U S A 116(44):22246-22251, 2019. e-Pub 2019. PMID: 31611368.
- Abu-Sbeih H, Ali FS, Naqash AR, Owen DH, Patel S, Otterson GA, Kendra K, Ricciuti B, Chiari R, De Giglio A, Sleiman J, Funchain P, Wills B, Zhang J, Naidoo J, Philpott J, Gao J, Subudhi SK, Wang Y. Resumption of Immune Checkpoint Inhibitor Therapy After Immune-Mediated Colitis. J Clin Oncol 37(30):JCO1900320, 2019. e-Pub 2019. PMID: 31163011.
- Corn PG, Heath EI, Zurita A, Ramesh N, Xiao L, Sei E, Li-Ning-Tapia E, Tu SM, Subudhi SK, Wang J, Wang X, Efstathiou E, Thompson TC, Troncoso P, Navin N, Logothetis CJ, Aparicio AM. Cabazitaxel plus carboplatin for the treatment of men with metastatic castration-resistant prostate cancers: a randomised, open-label, phase 1-2 trial. Lancet Oncol 20(10):1432-1443, 2019. e-Pub 2019. PMID: 31515154.
- Sharma A, Subudhi SK, Blando J, Scutti J, Vence L, Wargo J, Allison JP, Ribas A, Sharma P. Anti-CTLA-4 immunotherapy does not deplete FOXP3+ regulatory T cells (Tregs) in human cancers. Clin Cancer Res 25(4):1233-1238, 2019. e-Pub 2018. PMID: 30054281.
- Choi K, Abu-Sbeih H, Samdani R, Nogueras Gonzalez G, Raju GS, Richards DM, Gao J, Subudhi S, Stroehlein J, Wang Y. Can Immune Checkpoint Inhibitors Induce Microscopic Colitis or a Brand New Entity?. Inflamm Bowel Dis 25(2):385-393, 2019. e-Pub 2018. PMID: 30169584.
- Wang Y, Wiesnoski DH, Helmink BA, Gopalakrishnan V, Choi K, DuPont HL, Jiang ZD, Abu-Sbeih H, Sanchez CA, Chang CC, Parra ER, Francisco-Cruz A, Raju GS, Stroehlein JR, Campbell MT, Gao J, Subudhi SK, Maru DM, Blando JM, Lazar AJ, Allison JP, Sharma P, Tetzlaff MT, Wargo JA, Jenq RR. Author Correction: Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis. Nat Med 25(1):188, 2019. PMID: 30479380.
- Wang Y, Wiesnoski DH, Helmink BA, Gopalakrishnan V, Choi K, DuPont HL, Jiang ZD, Abu-Sbeih H, Sanchez CA, Chang CC, Parra ER, Francisco-Cruz A, Raju GS, Stroehlein JR, Campbell MT, Gao J, Subudhi SK, Maru DM, Blando JM, Lazar AJ, Allison JP, Sharma P, Tetzlaff MT, Wargo JA, Jenq RR. Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis. Nat Med 24(12):1804-1808, 2018. e-Pub 2018. PMID: 30420754.
- Iyer PC, Cabanillas ME, Waguespack SG, Hu MI, Thosani S, Lavis VR, Busaidy NL, Subudhi SK, Diab A, Dadu R. Immune-Related Thyroiditis with Immune Checkpoint Inhibitors. Thyroid 28(10):1243-1251, 2018. PMID: 30132401.
- Goswami S, Apostolou I, Zhang J, Skepner J, Anandhan S, Zhang X, Xiong L, Trojer P, Aparicio A, Subudhi SK, Allison JP, Zhao H, Sharma P. Modulation of EZH2 expression in T cells improves efficacy of anti-CTLA-4 therapy. J Clin Invest 128(9):3813-3818, 2018. e-Pub 2018. PMID: 29905573.
- Bilen MA, Hess KR, Subudhi SK, Aparicio A, Kim J, Zurita-Saavedra AJ, Araujo JC, Corn PG, Stover J, Lin SH, Logothetis CJ, Tu SM. Clinical predictors of survival in patients with castration-resistant prostate cancer receiving sipuleucel-T cellular immunotherapy. Cancer Chemother Pharmacol 80(3):583-589, 2017. e-Pub 2017. PMID: 28730293.
- Gao J, Ward JF, Pettaway CA, Shi LZ, Subudhi SK, Vence LM, Zhao H, Chen J, Chen H, Efstathiou E, Troncoso P, Allison JP, Logothetis CJ, Wistuba II, Sepulveda MA, Sun J, Wargo J, Blando J, Sharma P. VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer. Nat Med 23(5):551-555, 2017. e-Pub 2017. PMID: 28346412.
- Subudhi SK, Aparicio A, Gao J, Zurita AJ, Araujo JC, Logothetis CJ, Tahir SA, Korivi BR, Slack RS, Vence L, Emerson RO, Yusko E, Vignali M, Robins HS, Sun J, Allison JP, Sharma P. Clonal expansion of CD8 T cells in the systemic circulation precedes development of ipilimumab-induced toxicities. Proc Natl Acad Sci U S A 113(42):11919-11924, 2016. e-Pub 2016. PMID: 27698113.
- Shi LZ, Fu T, Guan B, Chen J, Blando JM, Allison JP, Xiong L, Subudhi SK, Gao J, Sharma P. Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+a-PD-1 therapy. Nat Commun 7:12335, 2016. e-Pub 2016. PMID: 27498556.
- Bilen MA, Subudhi SK, Gao J, Tannir NM, Tu SM, Sharma P. Acute rhabdomyolysis with severe polymyositis following ipilimumab-nivolumab treatment in a cancer patient with elevated anti-striated muscle antibody. J Immunother Cancer 4:36, 2016. e-Pub 2016. PMID: 27330809.
- Zamarin D, Holmgaard RB, Subudhi SK, Park JS, Mansour M, Palese P, Merghoub T, Wolchok JD, Allison JP. Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy. Sci Transl Med 6(226):226ra32, 2014. PMID: 24598590.
- Arora VK, Schenkein E, Murali R, Subudhi SK, Wongvipat J, Balbas MD, Shah N, Cai L, Efstathiou E, Logothetis C, Zheng D, Sawyers CL. Glucocorticoid receptor confers resistance to antiandrogens by bypassing androgen receptor blockade. Cell 155(6):1309-22, 2013. PMID: 24315100.
- Reis BS, Jungbluth AA, Frosina D, Holz M, Ritter E, Nakayama E, Ishida T, Obata Y, Carver B, Scher H, Scardino PT, Slovin S, Subudhi SK, Reuter VE, Savage C, Allison JP, Melamed J, Jäger E, Ritter G, Old LJ, Gnjatic S. Prostate cancer progression correlates with increased humoral immune response to a human endogenous retrovirus GAG protein. Clin Cancer Res 19(22):6112-25, 2013. e-Pub 2013. PMID: 24081977.
- Ross RW, Galsky MD, Scher HI, Magidson J, Wassmann K, Lee GS, Katz L, Subudhi SK, Anand A, Fleisher M, Kantoff PW, Oh WK. A whole-blood RNA transcript-based prognostic model in men with castration-resistant prostate cancer: a prospective study. Lancet Oncol 13(11):1105-13, 2012. e-Pub 2012. PMID: 23059047.
- Anders RA, Subudhi SK, Wang J, Pfeffer K, Fu YX. Contribution of the lymphotoxin beta receptor to liver regeneration. J Immunol 175(2):1295-300, 2005. PMID: 16002734.
- Wang Y, Subudhi SK, Anders RA, Lo J, Sun Y, Blink S, Wang Y, Wang J, Liu X, Mink K, Degrandi D, Pfeffer K, Fu YX. The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses. J Clin Invest 115(3):711-7, 2005. PMID: 15696194.
- Baron BW, Anastasi J, Montag A, Huo D, Baron RM, Karrison T, Thirman MJ, Subudhi SK, Chin RK, Felsher DW, Fu YX, McKeithan TW, Baron JM. The human BCL6 transgene promotes the development of lymphomas in the mouse. Proc Natl Acad Sci U S A 101(39):14198-203, 2004. e-Pub 2004. PMID: 15375218.
- Subudhi SK, Zhou P, Yerian LM, Chin RK, Lo JC, Anders RA, Sun Y, Chen L, Wang Y, Alegre ML, Fu YX. Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection. J Clin Invest 113(5):694-700, 2004. PMID: 14991067.
- Tang Q, Henriksen KJ, Boden EK, Tooley AJ, Ye J, Subudhi SK, Zheng XX, Strom TB, Bluestone JA. Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells. J Immunol 171(7):3348-52, 2003. PMID: 14500627.
- Sun Y, Chen HM, Subudhi SK, Chen J, Koka R, Chen L, Fu YX. Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease. Nat Med 8(12):1405-13, 2002. e-Pub 2002. PMID: 12426559.
- Tang Q, Subudhi SK, Henriksen KJ, Long CG, Vives F, Bluestone JA. The Src family kinase Fyn mediates signals induced by TCR antagonists. J Immunol 168(9):4480-7, 2002. PMID: 11970992.
- Sun Y, Lin X, Chen HM, Wu Q, Subudhi SK, Chen L, Fu YX. Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis. J Immunol 168(3):1457-65, 2002. PMID: 11801689.
- Tesciuba AG, Subudhi SK, Rother RP, Faas SJ, Frantz AM, Elliot D, Weinstock J, Matis LA, Bluestone JA, Sperling AL. Inducible costimulator regulates Th2-mediated inflammation, but not Th2 differentiation, in a model of allergic airway disease. J Immunology 167(4):1996-2003, 2001. PMID: 11489981.
- Cassel DL, Subudhi SK, Surrey S, McKenzie SE. GATA and NF-Y participate in transcriptional regulation of FcgammaRIIA in megakaryocytic cells. Blood Cells Mol Dis 26(6):587-97, 2000. PMID: 11112392.
Invited Articles
- Fayle SE, Palaskas NL, Siddiqui BA, McQuade JL, Lin JS, Subudhi SK, Patel AB, Jenq RR, Shah AY, Spelman AR, Sun M, Marble BH, Wang Y. Development of a Strategic Initiative at MD Anderson Cancer Center to Improve Outcomes in Immune-Related Adverse Events. J Natl Compr Canc Netw 22(5), 2024. e-Pub 2024. PMID: 38190801.
- Sharma P, Goswami S, Raychaudhuri D, Siddiqui BA, Singh P, Nagarajan A, Liu J, Subudhi SK, Poon C, Gant KL, Herbrich SM, Anandhan S, Islam S, Amit M, Anandappa G, Allison JP. Immune checkpoint therapy-current perspectives and future directions. Cell 186(8):1652-1669, 2023. PMID: 37059068.
- Siddiqui BA, Subudhi SK, Sharma P. Anti-PD-L1 plus enzalutamide does not improve overall survival in prostate cancer. Cell Rep Med 3(4):2666-3791, 2022. e-Pub 2022. PMID: 35492243.
- Goswami S, Siddiqui BA, Subudhi SK, Basu S, Yadav SS, Diab A, Sharma P. A composite T cell biomarker in pre-treatment blood samples correlates with detection of immune-related adverse events. Cancer Cell 40(3):249-251, 2022. PMID: 35290784.
- Cable J, Greenbaum B, Pe'er D, Bollard CM, Bruni S, Griffin ME, Allison JP, Wu CJ, Subudhi SK, Mardis ER, Brentjens R, Sosman JA, Cemerski S, Zavitsanou AM, Proia T, Egeblad M, Nolan G, Goswami S, Spranger S, Mackall CL. Frontiers in cancer immunotherapy-a symposium report. Ann N Y Acad Sci 1489(1):30-47, 2021. e-Pub 2020. PMID: 33184911.
- Sharma P, Siddiqui BA, Anandhan S, Yadav SS, Subudhi SK, Gao J, Goswami S, Allison JP. The Next Decade of Immune Checkpoint Therapy. Cancer Discov 11(4):838-857, 2021. PMID: 33811120.
- Subudhi SK. New approaches to immunotherapy for metastatic castration-resistant prostate cancer. Clin Adv Hematol Oncol 17(5):283-286, 2019. PMID: 31188806.
- Sheth RA, Perkons N, Dondossola E, Subudhi SK, Gade TP, Tam AL. Patient-Derived Xenograft Tumor Models: Overview and Relevance to IR. J Vasc Interv Radiol 29(6):880-882.e1, 2018. PMID: 29798759.
- Özdemir BC, Siefker-Radtke AO, Campbell MT, Subudhi SK. Current and Future Applications of Novel Immunotherapies in Urological Oncology: A Critical Review of the Literature. Eur Urol Focus 4(3):442-454, 2018. e-Pub 2017. PMID: 29056275.
- Laccetti AL, Subudhi SK. Immunotherapy for metastatic prostate cancer: immuno-cold or the tip of the iceberg?. Curr Opin Urol 27(6):566-571, 2017. e-Pub 2017. PMID: 28825923.
- Miyahira AK, Roychowdhury S, Goswami S, Ippolito JE, Priceman SJ, Pritchard CC, Sfanos KS, Subudhi SK, Simons JW, Pienta KJ, Soule HR. Beyond Seed and Soil: Understanding and Targeting Metastatic Prostate Cancer; Report From the 2016 Coffey-Holden Prostate Cancer Academy Meeting. Prostate 77(2):123-144, 2017. e-Pub 2016. PMID: 27679977.
- Goswami S, Aparicio A, Subudhi SK. Immune Checkpoint Therapies in Prostate Cancer. Cancer J 22(2):117-20, 2016. PMID: 27111907.
- Gao J, He Q, Subudhi S, Aparicio A, Zurita-Saavedra A, Lee DH, Jimenez C, Suarez-Almazor M, Sharma P. Review of immune-related adverse events in prostate cancer patients treated with ipilimumab: MD Anderson experience. Oncogene 34(43):5411-5417, 2015. e-Pub 2015. PMID: 25659583.
- Subudhi SK, Alegre ML, Fu YX. The balance of immune responses: co-stimulation verse co-inhibition. J Mol Med (Berl) 83(3):193-202, 2005. e-Pub 2005. PMID: 15630593.
- Sun Y, Subudhi SK, Fu YX. Co-stimulation agonists as a new immunotherapy for autoimmune diseases. Trends Mol Med 9(11):483-9, 2003. PMID: 14604826.
Other Articles
- Shannon VR, Subudhi SK, Huo L, Faiz SA Diffuse alveolar hemorrhage with nivolumab monotherapy. Respir Med Case Rep 30:101131, 2020. PMID: 32577370.
Editorials
- Sharma A, Subudhi SK, Blando J, Scutti J, Vence L, Wargo J, Allison JP, Ribas A, Sharma P. Anti-CTLA-4 Immunotherapy Does Not Deplete FOXP3+ Regulatory T Cells (Tregs) in Human Cancers-Response. Clin Cancer Res 25(11):3469-3470, 2019. PMID: None.
- Curran MA, Callahan MK, Subudhi SK, Allison JP. Response to "Ipilimumab (Yervoy) and the TGN1412 catastrophe". Immunobiology 217(6):590-2, 2012. PMID: 22459268.
- Subudhi SK, Callahan MK, Wolchok JD. Improving the therapeutic benefits of ipilimumab. Oncology (Williston Park) 24(14):1288, 1294, 2010. PMID: 21294472.
Abstracts
- Subudhi SK, Hauke RJ, Call JA, Sun J, Casey D, Wei XX. LORIKEET: A phase 2, randomized, open-label study of lorigerlimab plus docetaxel versus docetaxel alone in patients with metastatic castration-resistant prostate cancer (mCRPC). American Society of Clinical Oncology, Genitourinary Cancers Symposium 2024, 2024. PMID: None.
- Siddiqui BA, Palaskas N, Basu S, He Z, Sheth R, Buja M, Bhattacharjee M, Mancuso J, Fu T, Iliescu C, Deswal A, Rawther-Karedath A, Yadav SS, Allison JP, Sharma P, Subudhi SK. Identifying molecular targets for rational immunosuppressive strategies in severe immune checkpoint therapy (ICT)-induced myocarditis and myositis. American Society for Clinical Oncology (ASCO) Annual Meeting 2023, 2023. PMID: None.
- Hahn AW, Tidwell RS, Thoman W, Abdulla A, Koutroumpakis E, Aparicio A, Subudhi SK, Siddiqui BA, Pilié PG, Zurita AJ, Corn PG, Laccetti AL, Jana BR, Basen-Engquist K, Logothetis C. A phase II trial modifying metabolic syndrome and cardiovascular risk for patients with prostate cancer on ADT using a risk factor modification program and continuous Fitbit monitoring (ProTrio). Journal of Clinical Oncology, Genitourinary Cancer Symposium 2023, 2023. PMID: None.
- Pilié PG, Tidwell RS, Viscuse PV, Subudhi SK, Corn PG, Tu S, Araujo JC, Zurita AJ, Wang J, Efstathiou E, Deinert J, Logothetis C, Thompson TC, Aparicio A. Randomized phase II study of olaparib (Ola) maintenance following cabazitaxel-carboplatin induction chemotherapy (CabCarb) in men with aggressive variant prostate cancer (AVPC). None, 2023. PMID: None.
- Palaskas NL, Lu Y, Caldwell R, Oderinde P, Pina G, Ali A, Shah K, Iliescu C, Yusuf SW, Koutroumpakis E, Khalaf S, Hamzeh I, Siddiqui BA, Subudhi SK, Deswal A. Use of positron emission tomography for the diagnosis of immune checkpoint inhibitor myocarditis. Society for Immunotherapy of Cancer (SITC) Annual Meeting, 2022. PMID: None.
- Hahn AW, Siddiqui, BA, Logothetis CJ, Subudhi SK, Corn PG, Pilie P, Zurita AJ, Aparicio AM, Tidwell, R S, Thoman, W, Abdulla, A, Koutroumpakis, E, Laccetti, A L, Jana, B, Basen-Engquist, K. A phase II trial modifying metabolic syndrome and cardiovascular risk for prostate cancer patients on ADT using a risk factor modification program and continuous Fitbit monitoring (ProTrio). American Society for Clinical Oncology (ASCO), 2022. PMID: None.
- Caldwell R, Pina G, Oderinde P, Ali A, Garrett J, Siddiqui BA, Subudhi SK, Iliescu C, Yusuf SW, Koutroumpakis E, Hamzeh E, Khalaf S, Deswal A, Palaskas NL. Elevated serum TNF-α is a candidate prognostic biomarker for immune checkpoint inhibitor myocarditis. Society for Immunotherapy of Cancer (SITC) Annual Meeting, 2022. PMID: None.
- Subudhi SK, Siddiqui BA, Chapin BF, Jindal S, Duan F, Basu S, Yadav SS, Gu AD, Pettaway C, Ward JF, Tidwell RS, Corn PG, Logothetis CJ, Knoblauch RE, Hutnick NA, Gottardis MM, Drake CG, Allison JP, Sharma P. Daratumumab (Anti-CD38) But Not Edicotinib (CSF-1R Inhibitor) Demonstrates Target Engagement Within the Primary Prostate Cancer, Bone Marrow and Systemic Circulation of Patients with Localized Disease. International Cancer Immunotherapy Conference (CICON) 2022, 2022. PMID: None.
- Siddiqui BA, Palaskas N, Sheth R, Basu S, Tummala S, Lu HL, Hosing C, Rawther-Karedath A, Yadav SS, Sharma P, Subudhi SK. Identifying molecular targets for rational immunosuppressive strategies in severe immune checkpoint therapy (ICT)-induced myocarditis, myositis, and myasthenia gravis (MG). International Cancer Immunotherapy Conference (CICON) 2022, 2022. PMID: None.
- Palaskas NL, Siddiqui BA, Shah K, Koutroumpakis E, Iliescu C, Subudhi SK, Deswal A. Upfront immunomodulatory treatment of immune checkpoint inhibitor myocarditis. American College of Cardiology (ACC) Annual Meeting, 2022. PMID: None.
- Hahn AW, Wang X, Efstathiou E, Hwang H, Zurita AJ, Wang J, Araujo JC, Pilie P, Siddiqui BA, Subudhi SK, Corn PG, Aparicio AM, Tu SM, Logothetis CJ. Third analysis of a randomized trial of finite abiraterone acetate (AA) plus LHRH agonist (LHRHa) versus LHRHa in biochemically recurrent, non-metastatic hormone naïve prostate cancer (M0HNPC). American Society for Clinical Oncology (ASCO), 2022. PMID: None.
- Viscuse P, Tidwell R, Liu J, Guo S, Vundavilli H, Zhang M, Subudhi S, Zurita A, Corn P, Tu S, Araujo J, Wang J, Efstathiou E, Wang J, Pilié P, Troncoso P, Zhang J, Wang W, Logothetis C, Aparicio A. DynAMo: A dynamic allocation modular sequential trial of approved and promising therapies in men with metastatic CRPC. American Society for Clinical Oncology (ASCO), 2022. PMID: None.
- Siddiqui BA, Chapin BF, Jindal S, Duan F, Yadav SS, Pettaway C, Ward JF, Tidwell RS, Corn PG, Logothetis CJ, Allison JP, Sharma P, Subudhi SK. Target Modulation within the Tumor Microenvironment (TME) by Daratumumab (anti-CD38) but not Edicotinib (CSF-1R inhibitor) in Men with High-Risk Localized Prostate Cancer. Society for Immunotherapy of Cancer (SITC) Annual Meeting, 2021. PMID: None.
- Efstathiou E, Boukovala MA, Spetsieris N, Wen S, Hoang A, Weldon JA, Tidwell R, Davis JW, Chapin BF, Corn PG, Subudhi SK, Aparicio A, Pettaway CA, Pisters LL, Papadopoulos JN, Adibi M, Wang J, Zurita AJ, Logothetis C, Troncoso P. Neoadjuvant apalutamide (APA) plus leuprolide (LHRHa) with or without abiraterone (AA) in localized high-risk prostate cancer (LHRPC). Journal of Clinical Oncology, ASCO Annual Meeting 2020, 2020. PMID: None.
- Viscuse PV, Zhang M, Liu J, Tidwell RS, Subudhi SK, Zurita AJ, Corn PG, Tu S, Araujo JC, Wang J, Efstathiou E, Wang J, Pilie PG, Troncoso P, Zhang J, Logothetis C, Aparicio A. Linking the Aggressive Variant Prostate Cancer (AVPC) molecular signature (-ms) to androgen indifference in a prospective clinical trial. Journal of Clinical Oncology, Genitourinary Cancer Symposium 2020, 2020. PMID: None.
- Tran B, Kouros-Mehr H, Fermin A, Horvath L, Roncolato F, Rettig M, Dorff T, Tagawa ST, Subudhi SK, Antonarakis ES, Armstrong AJ, Petrylak DP, Fizazi K, Salvati ME, Scher HI. A Phase 1 Study of AMG 160, A Half-life Extended Bispecific T Cell Engager (HLE Bite) Immuno-Oncology Therapy Targeting PSMA, in Patients (PTS) with Metastatic Castration-Resistant Prostate Cancer (MCRPC). Annals of Oncology, European Society for Medical Oncology 2019, 2019. PMID: None.
- Chapin BF, Wang X, Zhang M, Corn PG, Zurita AJ, Elsheshtawi MA, Davis JW, Pettaway CA, Adibi M, Gleave M, Cooperberg MR, Smaldone MC, Mcguire SE, Tu S, Wang J, Subudhi SK, Efstathiou E, Logothetis C, Troncoso P, Aparicio A. Complex biologic heterogeneity of de novo hormone naïve metastatic prostate cancer (HNPCa): Comparison of early progressors and prolonged responders to initial systemic treatment. Journal of Clinical Oncology, ASCO Annual Meeting 2019, 2019. PMID: None.
- Siddiqui BA, Durand J, Gao J, Wang J, Aparicio A, Campbell MT, Siefker-Radtke AO, Tannir NM, Corn PG, Msaouel P, Shah AY, Zurita AJ, Tu S, Suarez-Almazor ME, Sudhakar T, Logothetis C, Sharma P, Subudhi SK. Clinical and immunological analyses of immune checkpoint inhibitor-associated neuromuscular (NM) toxicities. Journal of Clinical Oncology, ASCO Annual Meeting 2019, 2019. PMID: None.
- Abu-Sbeih H, Ali F, Naqash AR, Owen DH, Patel SH, Otterson GA, Kendra KL, Ricciuti B, Chiari R, Giglio AD, Sleiman J, Funchain P, Beatriz W, Zhang J, Naidoo J, Philpott J, Gao J, Subudhi SK, Wang Y. Immune-mediated colitis after resumption of immune checkpoint inhibitor therapy. Journal of Clinical Oncology, ASCO Annual Meeting 2019, 2019. PMID: None.
- Drake CG, Pachynski RK, Subudhi SK, McNeel DG, Antonarakis ES, Bauer TM, Patricia D, Wade M, Zudaire E, Mason G, Knoblauch RE, Stone NL, Infante JR, Gottardis M, Fong L. Safety and preliminary immunogenicity of JNJ-64041809, a live attenuated, double-deleted Listeria monocytogenes-based immunotherapy, in metastatic castration-resistant prostate cancer (mCRPC). Journal of Clinical Oncology, ASCO Annual Meeting 2019, 2019. PMID: None.
- Subudhi SK, Aparicio A, Zurita AJ, Doger B, Kelly WK, Peer A, Rathkopf DE, Karsh LI, Tryon JJ, Kothari N, Zhao X, Zhu E, Ricci DS, Tran N, De Bono JS. A phase Ib/II study of niraparib combination therapies for the treatment of metastatic castration-resistant prostate cancer (NCT03431350). Journal of Clinical Oncology, ASCO Annual Meeting 2019, 2019. PMID: None.
- Aparicio A, Zhang M, Ramesh N, Wang X, Corn PG, Zurita AJ, Davis JW, Pettaway CA, Adibi M, Mcguire SE, Tu S, Wang J, Subudhi SK, Elsheshtawi MA, Efstathiou E, Logothetis C, Navin N, Troncoso P, Chapin BF. Aggressive variant prostate cancer (AVPC) molecular signature in castration-sensitive, de novo metastatic prostate cancer (M1PCa). Journal of Clinical Oncology, ASCO Annual Meeting 2019, 2019. PMID: None.
- Sharma P, Pachynski RK, Narayan V, Flechon A, Gravis G, Galsky MD, Mahammedi H, Patnaik A, Subudhi SK, Ciprotti M, Duan T, Saci A, Hu S, Han G, Fizazi K. Initial results from a phase II study of nivolumab (NIVO) plus ipilimumab (IPI) for the treatment of metastatic castration-resistant prostate cancer (mCRPC; CheckMate 650). Journal of Clinical Oncology, Genitourinary Cancer Symposium 2019, 2019. PMID: None.
- Sharma P, Pachynski RK, Narayan V, Flechon A, Gravis G, Galsky MD, Mahammedi H, Patnaik A, Subudhi SK, Ciprotti M, Duan T, Saci A, Hu S, Han G, Fizazi K. Initial results from a phase II study of nivolumab (NIVO) plus ipilimumab (IPI) for the treatment of metastatic castration-resistant prostate cancer (mCRPC; CheckMate 650). Journal of Clinical Oncology, Genitourinary Oncology Symposium 2019, 2019. PMID: None.
- Efstathiou E, Wang X, Zurita AJ, Tu S, Aparicio A, Wang J, Corn PG, Subudhi SK, Araujo JC, Reece LK, Pruitt L, Vanalstine ML, Logothetis C. A randomized study of finite abiraterone acetate (AA) plus leuprolide (LHRHa) versus LHRHa in biochemically recurrent non metastatic hormone naïve prostate cancer (M0HNPC). Journal of Clinical Oncolocy, ASCO Annual Meeting 2018, 2018. PMID: None.
- Corn PG, Subudhi SK, Araujo JC, Vardaki I, Aparicio A, Tu S, Pagliaro LC, Zurita AJ, Logothetis C, Panaretakis T. Molecular profiling of liquid biopsies from patients (pts) with bone metastatic castration-resistant prostate cancer (BM-CRPC) treated with radium-223 (RA-223) to reveal differential enrichment for markers that correlate with overall survival (OS). Add to Collection. Journal of Clinical Oncology, Genitourinary Oncology Symposium 2018, 2018. PMID: None.
- Subudhi SK, Aparicio A, Troncoso P, Zhang J, Gumbs C, Wu CJ, Gao J, Vence LM, Blando JM, Corn PG, Araujo JC, Zurita AJ, Prokhorova IN, Van Alstine M, Logothetis C, Futreal A, Allison JP, Sharma P. Investigation of mechanisms of resistance to ipilimumab therapy with a pre-surgical trial in patients with high-risk, localized prostate cancer. Journal of Clinical Oncology, ASCO Annual Meeting 2017 35, 2017. PMID: None.
- Subudhi SK, Aparicio A, Troncoso P, Zhang J, Gumbs C, Wu C, Gao J, Vence LM, Blando JM, Corn PG, Araujo JC, Zurita AJ, Prokhorova IN, Alstine MV, Logothetis C, Futreal A, Allison JP, Sharma P. Linking tumor mutational load to clinical responses to ipilimumab (IPI) in men with advanced prostate cancer (PCa). Journal of Clinical Oncology, ASCO Annual Meeting 2017 35, 2017. PMID: None.
- Corn PG, Zurita AJ, Subudhi SK, Tu S, Aparicio A, Araujo JC, Kim J, Wang J, Efstathiou E, Pagliaro LC, Logothetis C. Cabozantinib plus androgen deprivation therapy in patients with androgen-dependent metastatic prostate cancer. Journal of Clinical Oncology, Genitourinary Oncology Symposium 2017, 2017. PMID: None.
- Odisio BC, Christensen JA, Subudhi SK, Huang S, Gupta S, Ahrar K, Sheth R, Ensor J, Aparicio A. Image guided thermal ablation of prostate cancer metastases to the liver. Journal of Clinical Oncology, ASCO Annual Meeting 2016, 2016. PMID: None.
- Subudhi SK, Aparicio A, Troncoso P, Zhang J, Gumbs C, Wu CJ, Vence LM, Logothetis CJ, Futreal A, Allison JP, Sharma P. A Feasibility Study to Determine T Cell Responses to Neoantigens Following Treatment with Ipilimumab in Men with Metastatic Castration-Resistant Prostate Carcinoma (mCRPC). Journal of Clinical Oncology, ASCO Annual Meeting 2016 34, 2016. PMID: None.
- Subudhi S, Aparicio A, Gao J, Zurita-Saavedra A, Araujo JC, Logothetis CJ, Brinda KR, Allison JP, Vence L, Emerson RO, Yusko E, Vignali M, Robins HS, Sun J, Sharma P. Exploratory biomarkers that predict for clinical outcomes in a Phase II trial with ipilimumab plus finite androgen deprivation therapy for metastatic non-castrate prostate cancer. Cancer Res, AACR 2016 Annual Meeting, 2016. PMID: None.
- Subudhi, SK, Aparicio A, Gao J, Zurita AJ, Araujo J, Logothetis CJ, Rao B, Vence L, Allison JP, Emerson R, Yusko E, Vignali M, Robins R, Sun J, Sharma P. Finite androgen deprivation therapy (ADT) plus ipilimumab (IPI) in metastatic non-castrate prostate cancer. Prostate Cancer Foundation (PCF) - 22nd Annual Scientific Retreat, 2015. PMID: None.
- Chapin BF, Mcguire SE, Wang X, Troncoso P, Davis JW, Navai N, Subudhi SK, Zurita AJ, Araujo JC, Pettaway CA, Matin SF, Pisters LL, Ward JF, Tu S, Wang J, Le O, Logothetis C, Aparicio A. A prospective, multicenter, randomized phase II trial of best systemic therapy (BST) or BST plus definitive treatment (Surgery or Radiation) of the primary tumor in metastatic prostate cancer. Journal of Clinical Oncology, ASCO Annual Meeting 2015, 2015. PMID: None.
- Corn PG, Tu S, Zurita AJ, Subudhi SK, Araujo JC, Kim J, Jonasch E, Pagliaro LC, Siefker-Radtke AO, Wang J, Wang X, Heath EI, Logothetis C, Aparicio A. A multi-institutional randomized phase II study (NCT01505868) of cabazitaxel (CAB) plus or minus carboplatin (CARB) in men with metastatic castration-resistant prostate cancer (mCRPC). Journal of Clinical Oncology, ASCO Annual Meeting 2015, 2015. PMID: None.
- Subudhi SK, Aparicio A, Gao J, Zurita AJ, Araujo J, Logothetis CJ, Rao B, Vence L, Allison JP, Emerson R, Yusko E, Vignali M, Robins H, Sun J, Sharma P. Immune correlates in a Phase II clinical trial with ipilimumab in combination with finite androgen deprivation therapy in patients with metastatic non-castrate prostate cancer. SITC - Society of Immunotherapy, Advances in Cancer Immunotherapy, 2015. PMID: None.
- Subudhi SK, Aparicio A, Zurita AJ, Araujo JC, Corn PG, Tu S, Wang X, Harris DR, Winslow KA, Gao J, Logothetis CJ, Sharma P. Finite androgen deprivation therapy (ADT) plus ipilimumab (IPI) in men with hormone-naïve metastatic prostate cancer (HN-mPCa). Annals of Oncology, ESMO, European Society for Medical Oncology 25, 2014. PMID: None.
- Zamarin D, Holmgaard RB, Subudhi SK, Park J, Mansour M, Palese P, Merghoub T, Wolchok JD, Allison JP. Potentiation of immune checkpoint blockade cancer immunotherapy with oncolytic virus. Journal of Clinical Oncology, ASCO Annual Meeting 2014, 2014. PMID: None.
- Subudhi SK, Heller G, Danila DC, Anand A, Lacuna KP, Samoila A, Fleisher M, Scher HI. Sera cytokine levels to predict survival in men with progressive castration-resistant prostate cancer. Journal of Clinical Oncology, ASCO Annual Meeting 2013 31, 2013. PMID: None.
- Subudhi SK, Montalvo-Ortiz W, Scher HI, Allison JP. Dissecting the therapeutic effects of anti-CTLA-4 and ADT in murine hormone-sensitive prostate cancer. Journal of Clinical Oncology, ASCO Annual Meeting 2013 31, 2013. PMID: None.
- Oh WK, Kantoff P, Scher HI, Magidson J, Wassmann K, Lee GM, Katz LM, Subudhi SK, Anand A, Fleisher M, Galsky MD, Ross RW. A validated whole-blood RNA transcript-based prognostic model that predicts survival in men with castration-resistant prostate cancer. Journal of Clinical Oncology, ASCO Annual Meeting 2012, 2012. PMID: None.
- Subudhi SK, Heller G, Anand A, Danila DC, Fleisher M, Scher HI. A Six-gene Panel that Predicts Survival in Men with Castration-resistant Prostate Cancer. Journal of Clinical Oncology, Genitourinary Cancers Symposium 2013 29, 2011. PMID: None.
Book Chapters
- Sharma P, Anandhan S, Siddiqui BA, Goswami S, Subudhi SK, Gao J, Peggs K, Quezada S, Allison JP. Cancer Immunotherapy. In: Cancer Medicine. 10th. None, 2020.
- Sharma P, Subudhi S, Peggs S, Goswani S, Gao J, Quezada S, Allison JP. Holland-Frei Cancer Medicine, 9th Edition. In: Chapter 67: Cancer Immunotherapy. 9. Wiley-Blackwell, 2017.
- Subudhi SK, Scher HI, Allison JP. CTLA-4 inhibitors in castration-resistant prostate cancer. In: Targeted Therapies for Castration-Resistant Prostate Cancer. None. Scardino PT, 2012.
Grant & Contract Support
| Title: | Prostate Moon Shot, PP3: Linking one-carbon metabolism to lineage promiscuity in aggressive variant prostate cancers (AVPC) |
| Funding Source: | MD Anderson Moon Shot Program |
| Role: | Clinical Leader |
| Title: | Prostate Moon Shot, PP1: Myeloid-Targeting strategies to overcome the immunosuppressive tumor microenvironment of lethal prostate cancer |
| Funding Source: | MD Anderson Moon Shot Program |
| Role: | Clinical Leader |
| Title: | Chemoimmunotherapy for Aggressive Variant Prostate Cancers (AVPC) |
| Funding Source: | Department of Defense (DOD) |
| Role: | Co-I |
| Title: | Prostate Moon Shot, PP3: Development of Bispecific Immunotherapy Strategies to Overcome the Immunosuppressive Prostate Tumor Microenvironment (Subudhi/Sharma) |
| Funding Source: | UT MD Anderson Cancer Center - Prostate Cancer Moon Shot PP3 |
| Role: | Co-Leader |
| Title: | PC190355 - Prostate cancer tryptophan metabolism alters the immune microenvironment and promotes aggressive variant phenotype |
| Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
| Role: | Collaborator |
| Title: | Flagship 2: Development of Rational Immunotherapy Combinations to Overcome the Immunosuppressive Prostate Tumor Microenvironment |
| Funding Source: | UT MD Anderson Cancer Center - Prostate Cancer Moon Shot |
| Role: | Co-Leader |
| Title: | Flagship 1: Development of Mechanism-based Combination Therapies for Castration-resistant Prostate Cancer Subproject: Targeting the Immunosuppressive Compartment of the Prostate Cancer Bone Metastatic Microenvironment to Improve Clinical Outcomes (Subudhi/Wang) |
| Funding Source: | UT MD Anderson Cancer Center - Prostate Cancer Moon Shot |
| Role: | Subproject Co-Leader |
| Title: | Targeting the Immunosuppressive Compartment of the Prostate Cancer Bone Metastatic Microenvironment to Improve Clinical Outcomes |
| Funding Source: | V Foundation/Lloyd Family Clinical Oncology Scholar Award |
| Role: | PI |
| Title: | RFA IO Combinations |
| Funding Source: | Janssen Research & Development, LLC |
| Role: | Co-I |
| Title: | Flagship 2: Targeting Immune Tumor-Associated Microenvironment in Prostate Cancer |
| Funding Source: | UT MD Anderson Cancer Center - Prostate Cancer Moon Shot |
| Role: | Co-I |
| Title: | MD Anderson Cancer Center Prostate Cancer SPORE – Project 1: Integrating Ipilimumab Immunotherapy with Approved Treatment Strategies in CRPC |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Title: | Targeting the Immune & Non-immune Tumor-associated Microenvironments in Prostate Cancer |
| Funding Source: | UT MD Anderson Cancer Center - Prostate Cancer Moon Shot |
| Role: | Co-I |
| Title: | A Feasibility Study to Determine T-Cell Responses to Neoantigens Following Treatment with Ipilimumab in Men with Metastatic Castration-Resistant Prostate Carcinoma (2014-0444) |
| Funding Source: | HI-CRSP |
| Role: | Co-I |
| Title: | Improving Patient Selection for Immune Checkpoint Therapy: Maximizing Benefit and Minimizing Toxicities |
| Funding Source: | Prostate Cancer Foundation |
| Role: | PI |
| Title: | National Institute of Health Clinical Scholars Biomedical Research Training Program |
| Funding Source: | NIH/NCI |
| Role: | Research Fellow |
| Title: | Targeting Immunosuppressive Myeloid Cells via the TGF-beta and VISTA Pathways to Overcome Resistance to Immune Checkpoint Therapies in Metastatic Castrate-Resistant Prostate Cancer to Bone |
| Funding Source: | NIH/NCI |
| Role: | Clinical Co-Leader |
Patient Reviews
CV information above last modified November 19, 2024