Tongxin Xie, MD,PHD

Peer-Reviewed Articles

1. Liu, N, Shi, X, Chen, S, Chen, H, Santi, MD, Phuong, DM, Fialho, MP, Xie, T, Gleber-Netto, FO, Latorre, R, Bunnett, NW, Viet, CT, Amit, M, Pan, H, Ye, Y. EGFR activation sensitizes trigeminal NMDA receptors to promote pain and morphine analgesic tolerance in oral cancer. Science Signaling 19(922):eadt3026, 2026. e-Pub 2026. PMID: 41592151.
2. Zhang, M, Yuan, M, Asam, K, Gong, Z, Xie, T, Gleber-Netto, FO, Santi, MD, Kobayashi, Y, Shimizu, E, Aouizerat, B, Amit, M, Boada, MD, Ye, Y. Perineural Invasion Exhibits Traits of Neurodegeneration. Journal of Dental Research 104(12):1352-1360, 2025. e-Pub 2025. PMID: 40492439.
3. Baruch EN, Gleber-Netto FO, Nagarajan P, Rao X, Akhter S, Eichwald T, Xie T, Balood M, Adewale A, Naara S, Sathishkumar HN, Islam S, McCarthy W, Mattson BJ, Ferrarotto R, Wong MK, Davies MA, Jindal S, Basu S, Roversi K, Nikpoor AR, Ahmadi M, Ahmadi A, Harwood C, Leigh I, Gong D, Tallon de Lara P, Tao DL, Davidson TM, Ajami NJ, Futreal A, Rai K, Kochat V, Castillo M, Gunaratne P, Goepfert RP, Hernandez SD, Khushalani NI, Wang J, Watowich SS, Calin GA, Migden MR, Yuan M, Liu N, Ye Y, Hwang WL, Vermeer PD, D'Silva NJ, Bunimovich YL, Yaniv D, Burks JK, Gomez J, Dougherty PM, Tsai KY, Allison JP, Sharma P, Wargo JA, Myers JN, Talbot S, Gross ND, Amit M. Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy. Nature, 2025. e-Pub 2025. PMID: 40836096.
4. Islam, S, Gleber-Netto, FO, Mulcahy, CF, Glaun, MD, Srivastava, S, Hunt, PJ, Williams, MD, Barbon, CE, Spiotto, MT, Zhao, W, Adebayo, A, Akhter, S, Xie, T, Debnath, KC, Sathishkumar, HN, Myers, B, Lothumalla, S, Yaman, I, Burks, JK, Gomez, JA, Rao, X, Wang, J, Woodman, K, Mansour, J, Arenkiel, BR, Osman, KL, Haxton, C, Lever, TE, Hutcheson, KA, Amit, M. Neural landscape is associated with functional outcomes in irradiated patients with oropharyngeal squamous cell carcinoma. Science translational medicine 16(758):eabq5585, 2024. e-Pub 2024. PMID: 39083586.
5. Pifer, PM, Yang, L, Kumar, M, Xie, T, Frederick, MJ, Hefner, A, Beadle, BM, Molkentine, D, Molkentine, JM, Dhawan, A, Abdelhakiem, M, Osman, AA, Leibowitz, BJ, Myers, JN, Pickering, CR, Sandulache, VC, Heymach, JV, Skinner, H. FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner. Clinical Cancer Research 30(1):187-197, 2024. e-Pub 2024. PMID: 37819945.
6. Shi, Y, Ren, X, Cao, S, Chen, X, Yuan, B, Brasil da Costa, FH, Rodriguez-Rosario, AE, Corona, A, Michikawa, C, Veeramachaneni, R, Osman, AA, Xie, T, Wang, W, Sikora, AG, Myers, JN, Rangel, R. TP53 gain-of-function mutation modulates the immunosuppressive microenvironment in non-HPV-associated oral squamous cell carcinoma. Journal for immunotherapy of cancer 11(8), 2023. e-Pub 2023. PMID: 37604640.
7. Ye, Y, Xie, T, Amit, M. Targeting the Nerve–Cancer Circuit. Cancer Research 83(15):2445-2447, 2023. e-Pub 2023. PMID: 37470842.
8. Baruch, EN, Nagarajan, P, Gleber-Netto, FO, Rao, X, Xie, T, Akhter, S, Adewale, A, Shajedul, I, Mattson, BJ, Ferrarotto, R, Wong, MK, Davies, MA, Jindal, S, Basu, S, Harwood, C, Leigh, I, Ajami, NJ, Futreal, A, Castillo, M, Gunaratne, PH, Goepfert, RP, Khushalani, N, Wang, J, Watowich, SS, Calin, GA, Migden, MR, Vermeer, PD, D'Silva, NJ, Yaniv, D, Burks, JK, Gomez, JA, Dougherty, PM, Tsai, KY, Allison, JP, Sharma, P, Wargo, J, Myers, JN, Gross, N, Amit, M. Inflammation induced by tumor-associated nerves promotes resistance to anti-PD-1 therapy in cancer patients and is targetable by interleukin-6 blockade. Research square, 2023. e-Pub 2023. PMID: 37503252.
9. Chen, Y‐, Zhao, W, Na'ara, S, Netto, FG, Xie, T, Ali, S, Thompson, Z, Buell, J, Stafford, H, Nagarajan, P, Davies, MA, Wong, MK, Migden, MR, Sharma, P, Myers, JN, Gross, N, Amit, M. Beta-Blocker Use Is Associated With Worse Relapse-Free Survival in Patients With Head and Neck Cancer. JCO Precision Oncology 7:e2200490, 2023. e-Pub 2023. PMID: 37285560.
10. Amit, M, Xie, T, Netto, FG, Hunt, PJ, Mehta, GU, Bell, D, Silverman, DA, Yaman, I, Ye, Y, Burks, JK, Fuller, GN, Gidley, PW, Nader, M, Raza, SM, DeMonte, F. Distinct immune signature predicts progression of vestibular schwannoma and unveils a possible viral etiology. Journal of Experimental and Clinical Cancer Research 41(1), 2022. e-Pub 2022. PMID: 36195959.
11. Shi, Y, Xie, T, Wang, B, Wang, R, Cai, Y, Yuan, B, Netto, FG, Tian, X, Rodriguez-Rosario, AE, Osman, AA, Wang, J, Pickering, CR, Ren, X, Sikora, AG, Myers, JN, Rangel, R. Mutant p53 drives an immune cold tumor immune microenvironment in oral squamous cell carcinoma. Communications Biology 5(1), 2022. e-Pub 2022. PMID: 35902768.
12. Santi, MD, Zhang, M, Salvo, E, Asam, K, Viet, CT, Xie, T, Amit, M, Aouizerat, B, Ye, Y. Schwann Cells Induce Phenotypic Changes in Oral Cancer Cells. Advanced Biology 6(9), 2022. e-Pub 2022. PMID: 35925609.

Review Articles

1. Santi, MD, Zhang, M, Liu, N, Viet, CT, Xie, T, Jensen, DD, Amit, M, Pan, H, Ye, Y. Repurposing EGFR Inhibitors for Oral Cancer Pain and Opioid Tolerance. Pharmaceuticals 16(11), 2023. e-Pub 2023. PMID: 38004424.
2. Yaman, I, Çobanoğlu, DA, Xie, T, Ye, Y, Amit, M. Advances in understanding cancer-associated neurogenesis and its implications on the neuroimmune axis in cancer. Pharmacology and Therapeutics 239, 2022. e-Pub 2022. PMID: 35490859.
3. Batalla-Covello, J, Ali, S, Xie, T, Amit, M. β-Adrenergic signaling in skin cancer. FASEB BioAdvances 4(4):225-234, 2022. e-Pub 2022. PMID: 35415461.

Editorials

1. Shi, Y, Tang, X, Xie, T, Zhang, Y, Ren, X. Editorial. Frontiers in Neurology 14, 2023. PMID: 37602237.

Abstracts

1. Pickering C, Kumar M, Bridges K, Xie T, Molkentine D, Sheth A, Yang L, Frederick M, Heffernan T, Seth S, Myers J, Skinner HD. Targeting histone acetyltransferase (HAT) function for synthetic cytotoxicity in CREBBP/EP300 mutant tumors. Proceedings of the American Association for Cancer Research Annual Meeting 2019, 2019. e-Pub 2019.
2. Colbert LE, Kumar M, Yang L, Molkentine D, Bridges, Kathleen, Myers JN, Xie T, Frederick MJ, Pickering C, Skinner, Heath. In Vivo shRNA Screening Reveals Differential Radiosensitization Within HPV+ and HPV- Head and Neck Squamous Cell Carcinomas. International Journal of Radiation Oncology*Biology*Physics, 2018. e-Pub 2018.
3. Huang C, Moorthy S, Li Q, Saade R, Wang J, Rao X, Tanaka N, Zhang J, Tang L, Pickering CR, Zweidler-McKay PA, Osman AA, Xie T, Shinbrot E, Xi L, Wheeler D, El-Naggar AK, Wang J, Myers JN, Frederick MJ. NOTCH1 activation in head and neck squamous cell carcinoma leads to growth inhibition, changes in gene expression associated with early differentiation, and acquisition of stem cell-like properties. Proceedings of the American Association for Cancer Research Annual Meeting 2018, 2018. e-Pub 2018.
4. Xie T. In Vivo Screening Identifies ESR1 as a Clinically Relevant Target for Radiosensitization In HNSCC. International Journal of Radiation Oncology • Biology • Physics, 2018. e-Pub 2018.
5. Xie T. In-vivo shRNA screening identifies synthetic cytotoxicity in CREBBP/EP300 mutant head and neck cancer. AACR Meeting-2018, 2018. e-Pub 2018.
6. Pickering CR, Xie T, Kumar M, Parimi RL, Yang LP, Wang J, Seth S, Bristow CA, Carugo A, Robinson FS, Draetta GF, Skinner H, Frederick MJ, Myers JN. In vivo shRNA library screening to identify novel targets for head and neck squamous cell carcinoma [abstract]. Proceedings of the American Association for Cancer Research Annual Meeting 2017, 2017. e-Pub 2017.
7. Xie T, Parimi RL, Kumar MF, Yang LP, Wang J, Seth S, Alessandro C, Bristow CA, Robinson FS, Peoples MD, Skinner H, Myers JN, Pickering CR, Frederick MJ. An in vivo high throughput shRNA screening platform for identifying ways to target genomic alterations [abstract]. Proceedings of the AACR-AHNS Head and Neck Cancer Conference: Optimizing Survival and Quality of Life through Basic, Clinical, and Translational Research, 2017. e-Pub 2017.
8. Xie T, Zhou G, Zhao M, Lozano G, Brennan R, Myers JN. Serine substituion of proline at codon 151 of TP53 leads to anoikis resistance, soft agar growth, and enhanced in vivo tumorigenicity of head and neck cancer cells and a putative conformational change within a hydrophobic subdomain of the p53 protein. 4th International Workshop on Mutant p53: “In vivo effects of mutant p53: experimental data, animal, models, clinical consequences”, 2009. e-Pub 2009.
9. Xie TX, Zhou G, Zhao M, Jasser SA, Myers JN. A mutant p53 promotes anoikis resistance by down-regulating Bmf in oral squamous carcinoma cells. 7th International Conference on Head and Neck Cancer 2008, 2008. e-Pub 2008.
10. Zhou G, Zhao M, Xie TX, Jasser SA, Myers JN. Gain of function of p53 mutations disrupt the ATM-mediated DNA damage response in HNSCC cell lines. 7th International Conference on Head and Neck Cancer 2008, 2008. e-Pub 2008.
11. Xie TX, Zhou G, Jasser SA, Zhao M, Wu X, Myers JN. Detachment-induced over expression of XIAP promotes resistance to anoikis of oral squamous carcinoma cells by down-regulating Htra2-Omi through ubiquitination. American Association for Cancer Research Annual Meeting 2008, 2008. e-Pub 2008.
12. Zhou G, Xie TX, Zhao M, Jasser S, Younes M, Sano D, Lin J, Kupferman M, Santillan A, Patel V, Gutkind JS, El-Naggar A, Emberely E, Watson P, Matsuzawa S, Reed J, Myers JN. Reciprocal negative regulation between S100A7/psoriasin and beta-catenin signaling plays an important role in tumor progression of squamous cell carcinoma of oral cavity. American Association for Cancer Research Annual Meeting 2008, 2008. e-Pub 2008.
13. Zhou G, Mandal M, Jasser SA, Zhao M, Dakak-Yazici Y, Xie TX, Younes MN, Kupferman ME, Patel V, Gutkind JS, EI-Naggar AK, Emberley ED, Watson PH, Bucana CD, Myers JN. Psoriasin/S100A7 modulates β-catenin signaling and inhibits tumor growth and progression of oral cavity squamous cell carcinoma. American Association for Cancer Research Annual Meeting 2007, 2007. e-Pub 2007.
14. Aoki K, Misiumi J, Kimura T, Zhao W, Xie TX. Evaluation of Cutoff Levels for screening of gastric cancer using serum pepsinogen. Jan. J. Hyg 58(1):1, 2003. e-Pub 2003.
15. Zhao W, Zhang X, Aoki K, Zhang Z, Xie TX, Kudo M, Bo YH, Kono A, Mi JM, Akshi H, Esaki F, Kurakake S, Misumi J. Differences in drinking water composition between three areas with different gastric cancer motalityrates in Zanhuang county, China. International Symposium on Biology of Cancer Prevention and Treatment 30, 1999. e-Pub 1999.
16. Aoki K, Misumi J, Zhao W, Kono A, Esaki, F, Xie TX, Zhang XH, Zhang ZG. Prevalence of helicobacter pylori infection in three areas with different gastric mortality rate in Zanhuang County in China. International Symposium on Biology of Cancer Prevention and Treatment 30, 1999. e-Pub 1999.
17. Wang FR, Zhang XH, Xie TX, Ma HJ, Zhang ZD. Mycotoxins and lung cancer. The 6th World Conference on Lung Cancer, 1991. e-Pub 1991.
18. Xie TX, Wang FR, Zhang ZD. Photolysis of sterigmatocystin by sunlight. Chinese Journal of Preventive Medicine 22:22, 1991. e-Pub 1991.
19. Zhang X, Xie TX, Wang JL, Yan X, Lu LM, Wang ZY, Wang FR. Carcinogenesis studies of the extract of aspergillus versicolor culture on the human fetal lung tissues in vitro. The 6th World Conference on International Lung Cancer, 1991. e-Pub 1991.

Book Chapters

1. Xie T. Tissue culture and sample preparation of cell suspension. In: Techniques of sample preparation for flow cytometry. In: Hua Xia Press: Beijing, China, 1991, 1991.