Vahid Afshar-Kharghan, M.D.
Department of Pulmonary Medicine, Division of Internal Medicine
Education & Training
Degree-Granting Education
| 1991 | Hacettepe University Faculty of Medicine, Ankara, TUR, MD, Medicine |
Postgraduate Training
| 1997-2000 | Research Fellowship, Baylor College of Medicine, Houston, TX |
| 1993-1997 | Clinical Residency, Baylor College of Medicine, Houston, TX |
| 1991-1993 | Graduate Training in the Department of Biotechnology, Middle East Technical University, Ankara |
| 1984-1991 | Medical School, Hacettepe University Faculty of Medicine, Ankara |
Board Certifications
| 2006 | American Board of Internal Medicine-Internal Medicine |
| 2001 | American Board of Internal Medicine-Hematology |
| 2000 | American Board of Internal Medicine-Medical Oncology |
| 1996 | American Board of Internal Medicine-Internal Medicine |
| 1992 | Educational Commission for Foreign Medical Graduates (ECFMG) |
Experience & Service
Academic Appointments
Associate Professor, Department of Pulmonary Medicine, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2008 - 2015
Administrative Appointments/Responsibilities
Staff Physician, Department of Medicine, Michael E. DeBakey VA Medical Center, Houston, TX, 2005 - 2008
Assistant Professor, Department of Medicine, Baylor College of Medicine, Houston, TX, 2000 - 2008
Selected Publications
Peer-Reviewed Articles
- Ma Q, Li D, Carreño R, Patenia R, Tsai KY, Xydes-Smith M, Alousi AM, Champlin RE, Sale GE, and Afshar-Kharghan V.. Complement component C3 mediates Th1/Th17 polarization in human T cell activation and cutaneous Graft-versus-Host Disease. Bone Marrow Transplantation 49(5):972-6, 2014. e-Pub 2014.
- Cho MS, Vasquez HG, Rupaimoole R, Pradeep S, Wu S, Zand B, Han H-D, Rodriguez-Aguayo C, Bottsford-Miller J, Huang J, Miyake T, Dalton H, Ivan C, Baggerly K, Lopez-Berestein G, Sood AK, and Afshar-Kharghan V.. Autocrine effects of tumor-derived complement. Cell Reports 6(6):1085-1095, 2014.
- Nolasco L, Feng S, Afshar-Kharghan V, Moake J.. Human complement factor H is a reductase for large soluble Von Willebrand factor multimers. Arteriosclerosis, Thrombosis, and Vascular Biology 33(11):2524-8, 2013.
- Feng S, Liang X, Cruz MA, Vu H, Zhou Z, Pemmaraju N, Dong JF, Kroll MH, Afshar-Kharghan V.. The interaction between Factor H and Von Willebrand Factor. PLOS ONE 8(8), 2013. e-Pub 2013.
- Feng S, Eyler SJ, Zhang Y, Maga T, Nester CM, Kroll MH, Smith RJ, Afshar-Kharghan V.. Partial ADAMTS13 deficiency in atypical hemolytic uremic syndrome. Blood. e-Pub 2013.
- Feng S, Kroll MH, Nolasco L, Moake J, Afshar-Kharghan V. Complement activation in thrombotic microangiopathies. Br J Haematol 160(3), 2013. e-Pub 2012. PMID: 23116127.
- Cho MS, Bottsford-Miller J, Vasquez HG, Stone R, Zand B, Kroll MH, Sood AK, Afshar-Kharghan V. Platelets increase the proliferation of ovarian cancer cells. Blood 120(24):4869-72, 2012. e-Pub 2012. PMID: 22966171.
- Ma Q, Li D, Nurieva R, Patenia R, Bassett R, Cao W, Alekseev AM, He H, Molldrem JJ, Kroll MH, Champlin RE, Sale GE, Afshar-Kharghan V. Reduced graft-versus-host disease in C3-deficient mice is associated with decreased donor Th1/Th17 differentiation. Biol Blood Marrow Transplant 18(8):1174-81, 2012. e-Pub 2012. PMID: 22664751.
- Stone RL, Nick AM, McNeish IA, Balkwill F, Han HD, Bottsford-Miller J, Rupaimoole R, Armaiz-Pena GN, Pecot CV, Coward J, Deavers MT, Vasquez HG, Urbauer D, Landen CN, Wei h, Gershenson H, Matsuo K, Shahzad MMK, King ER, Tekedereli I, Ozpolat B, Ahn EH, Bond VK, Wang R, Drew AF, Gushiken F, Collins K, DeGeest K, Lutgendorf SK, Chiu W, Lopez-Berestein G, Afshar-Kharghan V, Sood AK.. Paraneoplastic Thrombocytosis in Ovarian Cancer. New England Journal Of Medicine 366(7):610, 2012.
- Zalpour A, Kroll MH, Afshar-Kharghan V, Yusuf SW, Escalante C.. Role of factor Xa inhibitors in cancer-associated thrombosis: any new data?. Adv Hematol, 2011. e-Pub 2011.
- Divakaran V, Mehta S, Yao D, Hassan S, Simpson S, Wiegerinck E, Swinkels DW, Mann DL, Afshar-Kharghan V.. Hepcidin in anemia of chronic heart failure. Am. J. Hematology 86(1):107-9, 2011.
- Hanzelka KM, Zalpour A, Afshar-Kharghan V, Fitousis K, Anderlini P, Yeung SC. Severe thrombosis and acute thrombocytopenia in a cancer patient. Am J Hematol 85(11):887-90, 2010. PMID: 20721891.
- N, Russell BH, Rivera JJ, Liang X, Xu X, Afshar-Kharghan V, Hook M. An engineered a1 integrin binding collagenous sequence. J. Biol. Chem 285(40):31046-54. e-Pub 2010.
- Gushiken FC, Han H, Li J, Rumbaut RE, Afshar-Kharghan V. Abnormal platelet function in C3 deficient mice. Journal of Thrombosis and Haemostasis 7(5):865-70, 2009.
- Kulkarni PA, Afshar-Kharghan V. Anticomplement therapy. Biologics 2(4):671-685, 2008. PMID: 19707448.
- Mnjoyan z, Li J, Afshar-Kharghan. Factor H binds to platelet integrin allbB3. Platelets 19(7):512-9, 2008.
- Jelinek J, Li J, Mnjoyan Z, Issa JP, Prchal JT, Afshar-Kharghan V. Epigenetic control of PRV-1 expression on neutrophils. Exp Hematol 35(11):1677-83, 2007. PMID: 17976520.
- Diz-Kucukkaya R, Inanc M, Afshar-Kharghan V, Zhang QE, López JA, Pekcelen Y. P-selectin glycoprotein ligand-1 VNTR polymorphisms and risk of thrombosis in the antiphospholipid syndrome. Ann Rheum Dis 66(10):1378-80, 2007. e-Pub 2007. PMID: 17545190.
- Luo SZ, Mo X, Afshar-Kharghan V, Srinivasan S, López JA, Li R. Glycoprotein Ibalpha forms disulfide bonds with 2 glycoprotein Ibbeta subunits in the resting platelet. Blood 109(2):603-9, 2007. e-Pub 2006. PMID: 17008541.
- Mnjoyan Z, Yoon D, Li J, Delhommeau F, Afshar-Kharghan V. The effect of the JAK2 V617F mutation on PRV-1 expression. Haematologica 91(3):411-2, 2006. PMID: 16503546.
- Mnjoyan Z, Li J, Afshar-Kharghan V. Expression of polycythemia rubra vera-1 decreases the dependency of cells on growth factors for proliferation. Haematologica 90(3):405-6, 2005. PMID: 15749675.
- Del Conde I, Crúz MA, Zhang H, López JA, Afshar-Kharghan V. Platelet activation leads to activation and propagation of the complement system. J Exp Med 201(6):871-9, 2005. PMID: 15781579.
- Afshar-Kharghan V, Matijevic-Aleksic N, Ahn C, Boerwinkle E, Wu KK, López JA. The variable number of tandem repeat polymorphism of platelet glycoprotein Ibalpha and risk of coronary heart disease. Blood 103(3):963-5, 2004. e-Pub 2003. PMID: 14592833.
- Afshar-Kharghan V, López JA, Gray LA, Padilla A, Borthakur G, Roberts SC, Pruthi RK, Tefferi A. Hemostatic gene polymorphisms and the prevalence of thrombotic complications in polycythemia vera and essential thrombocythemia. Blood Coagul Fibrinolysis 15(1):21-4, 2004. PMID: 15166939.
- Meisel C, Afshar-Kharghan V, Cascorbi I, Laule M, Stangl V, Felix SB, Baumann G, López JA, Roots I, Stangl K. Role of Kozak sequence polymorphism of platelet glycoprotein Ibalpha as a risk factor for coronary artery disease and catheter interventions. J Am Coll Cardiol 38(4):1023-7, 2001. PMID: 11583876.
- Baker RI, Eikelboom J, Lofthouse E, Staples N, Afshar-Kharghan V, López JA, Shen Y, Berndt MC, Hankey G. Platelet glycoprotein Ibalpha Kozak polymorphism is associated with an increased risk of ischemic stroke. Blood 98(1):36-40, 2001. PMID: 11418460.
- Afshar-Kharghan V, Diz-Küçükkaya R, Ludwig EH, Marian AJ, López JA. Human polymorphism of P-selectin glycoprotein ligand 1 attributable to variable numbers of tandem decameric repeats in the mucinlike region. Blood 97(10):3306-7, 2001. PMID: 11342464.
- Afshar-Kharghan V, Craig FE, López JA. Bernard-Soulier syndrome in a patient doubly heterozygous for two frameshift mutations in the glycoprotein ib alpha gene. Br J Haematol 110(4):919-24, 2000. PMID: 11054083.
- Sachs UJ, Kiefel V, Böhringer M, Afshar-Kharghan V, Kroll H, Santoso S. Single amino acid substitution in human platelet glycoprotein Ibbeta is responsible for the formation of the platelet-specific alloantigen Iy(a). Blood 95(5):1849-55, 2000. PMID: 10688847.
- Afshar-Kharghan V, Gineys G, Schade AJ, Sun L, Li CQ, McIntire LV, Dong JF, López JA. Necessity of conserved asparagine residues in the leucine-rich repeats of platelet glycoprotein Ib alpha for the proper conformation and function of the ligand-binding region. Biochemistry 39(12):3384-91, 2000. PMID: 10727232.
- Afshar-Kharghan V, Li CQ, Khoshnevis-Asl M, López JA. Kozak sequence polymorphism of the glycoprotein (GP) Ibalpha gene is a major determinant of the plasma membrane levels of the platelet GP Ib-IX-V complex. Blood 94(1):186-91, 1999. PMID: 10381512.
- López JA, Andrews RK, Afshar-Kharghan V, Berndt MC. Bernard-Soulier syndrome. Blood 91(12):4397-418, 1998. PMID: 9616133.
- Afshar-Kharghan V, López JA. Bernard-Soulier syndrome caused by a dinucleotide deletion and reading frameshift in the region encoding the glycoprotein Ib alpha transmembrane domain. Blood 90(7):2634-43, 1997. PMID: 9326230.
- Dong JF, Li CQ, Sae-Tung G, Hyun W, Afshar-Kharghan V, López JA. The cytoplasmic domain of glycoprotein (GP) Ibalpha constrains the lateral diffusion of the GP Ib-IX complex and modulates von Willebrand factor binding. Biochemistry 36(41):12421-7, 1997. PMID: 9376345.
Grant & Contract Support
| Title: | Role of Platelets in Ovarian Cancer Pathogenesis |
| Funding Source: | Baylor/UT MD Anderson Cancer Center |
| Role: | Collaborator |
| Title: | The role of complement system in alloimmune responses |
| Funding Source: | NIH/NIAID |
| Role: | Co-Principal Investigator |
| Title: | Power of platelets in ovarian cancer |
| Funding Source: | Ovarian Cancer Research Fund |
| Role: | Investigator |
| Title: | Platelets promote the growth of ovarian cancer |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
Patient Reviews
CV information above last modified September 30, 2023