Xi Chen, Ph.D.
Department of Experimental Therapeutics, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Associate Member, James P. Allison Institute, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2009 | National University of Singapore, Singapore, SGP, PHD, Stem Cells |
Postgraduate Training
| 2012-2015 | Postdoctoral Fellowship, Weill Cornell Medical College, New York, NY |
| 2009-2012 | Postdoctoral Fellowship, Harvard School of Public Health and Harvard Medical School, Boston, MA |
Experience & Service
Academic Appointments
Associate Professor, Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, TX, 2021 - 2024
Assistant Professor, CPRIT Scholar in Cancer Research, Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, TX, 2015 - 2021
Endowed Positions
Cullen Duncan McAshan Endowed Chair in Cancer Research, Baylor College of Medicine, Houston, TX, 2021 - 2024
Honors & Awards
| 2021 | Cullen Duncan McAshan Endowed Chair in Cancer Research, Baylor College of Medicine |
| 2019 | DOD Peer Reviewed Cancer Research Program Impact Award, Department of Defense |
| 2019 | American Cancer Society Research Scholar, American Cancer Society |
| 2018 | NIH Merit Award for ESI, National Insitute of Health |
| 2016 | Susan G. Komen Career Catalyst Award, Susan G. Komen Breast Cancer Foundation |
| 2015 | CPRIT Scholar in Cancer Research, Cancer Prevention and Research Institute of Texas |
| 2015 | Breast Cancer SPORE Career Development Award, National Cancer Institute |
Selected Publications
Peer-Reviewed Articles
- Lv X, Lu X, Cao J, Luo Q, Ding Y, Peng F, Pataer A, Lu D, Han D, Malmberg E, Chan DW, Wang X, Savage SR, Mao S, Yu J, Peng F, Yan L, Meng H, Maneix L, Han Y, Chen Y, Yao W, Chang EC, Catic A, Lin X, Miles G, Huang P, Sun Z, Burt B, Wang H, Wang J, Yao QC, Zhang B, Roth JA, O'Malley BW, Ellis MJ, Rimawi MF, Ying H, Chen X. Modulation of the proteostasis network promotes tumor resistance to oncogenic KRAS inhibitors. Science 381(6662):eabn4180, 2023. e-Pub 2023. PMID: 37676964.
- Liu X, Yu J, Xu L, Umphred-Wilson K, Peng F, Ding Y, Barton BM, Lv X, Zhao MY, Sun S, Hong Y, Qi L, Adoro S, Chen X. Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β-selection. Elife 10, 2021. e-Pub 2021. PMID: 34240701.
- Chen X, Cubillos-Ruiz JR. Endoplasmic reticulum stress signals in the tumour and its microenvironment. Nat Rev Cancer 21(2):71-88, 2021. e-Pub 2020. PMID: 33214692.
- Xu L, Liu X, Peng F, Zhang W, Zheng L, Ding Y, Gu T, Lv K, Wang J, Ortinau L, Hu T, Shi X, Shi G, Shang G, Sun S, Iwawaki T, Ji Y, Li W, Rosen JM, Zhang XH, Park D, Adoro S, Catic A, Tong W, Qi L, Nakada D, Chen X. Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions. Nat Cell Biol 22(10):1162-1169, 2020. e-Pub 2020. PMID: 32958856.
- Lv X, Dobrolecki LE, Ding Y, Rosen JM, Lewis MT, Chen X. Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer. J Vis Exp(159), 2020. e-Pub 2020. PMID: 32478757.
- Zheng ZY, Anurag M, Lei JT, Cao J, Singh P, Peng J, Kennedy H, Nguyen NC, Chen Y, Lavere P, Li J, Du XH, Cakar B, Song W, Kim BJ, Shi J, Seker S, Chan DW, Zhao GQ, Chen X, Banks KC, Lanman RB, Shafaee MN, Zhang XH, Vasaikar S, Zhang B, Hilsenbeck SG, Li W, Foulds CE, Ellis MJ, Chang EC. Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer. Cancer Cell 37(3):387-402.e7, 2020. e-Pub 2020. PMID: 32142667.
- Xu L, Zhang W, Zhang XH, Chen X. Endoplasmic Reticulum Stress in Bone Metastases. Front Oncol 10:1100, 2020. e-Pub 2020. PMID: 32850317.
- Dong H, Adams NM, Xu Y, Cao J, Allan DSJ, Carlyle JR, Chen X, Sun JC, Glimcher LH. The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc. Nat Immunol 20(7):865-878, 2019. e-Pub 2019. PMID: 31086333.
- Liu L, Zhao M, Jin X, Ney G, Yang KB, Peng F, Cao J, Iwawaki T, Del Valle J, Chen X, Li Q. Adaptive endoplasmic reticulum stress signalling via IRE1α-XBP1 preserves self-renewal of haematopoietic and pre-leukaemic stem cells. Nat Cell Biol 21(3):328-337, 2019. e-Pub 2019. PMID: 30778220.
- Zhao N, Cao J, Xu L, Tang Q, Dobrolecki LE, Lv X, Talukdar M, Lu Y, Wang X, Hu DZ, Shi Q, Xiang Y, Wang Y, Liu X, Bu W, Jiang Y, Li M, Gong Y, Sun Z, Ying H, Yuan B, Lin X, Feng XH, Hartig SM, Li F, Shen H, Chen Y, Han L, Zeng Q, Patterson JB, Kaipparettu BA, Putluri N, Sicheri F, Rosen JM, Lewis MT, Chen X. Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer. J Clin Invest 128(4):1283-1299, 2018. e-Pub 2018. PMID: 29480818.
- Chen K, Chen Z, Wu D, Zhang L, Lin X, Su J, Rodriguez B, Xi Y, Xia Z, Chen X, Shi X, Wang Q, Li W. Broad H3K4me3 is associated with increased transcription elongation and enhancer activity at tumor-suppressor genes. Nat Genet 47(10):1149-57, 2015. e-Pub 2015. PMID: 26301496.
- Chen X, Iliopoulos D, Zhang Q, Tang Q, Greenblatt MB, Hatziapostolou M, Lim E, Tam WL, Ni M, Chen Y, Mai J, Shen H, Hu DZ, Adoro S, Hu B, Song M, Tan C, Landis MD, Ferrari M, Shin SJ, Brown M, Chang JC, Liu XS, Glimcher LH. XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway. Nature 508(7494):103-107, 2014. e-Pub 2014. PMID: 24670641.
- Zou W, Chen X, Shim JH, Huang Z, Brady N, Hu D, Drapp R, Sigrist K, Glimcher LH, Jones D. The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid. Nat Cell Biol 13(1):59-65, 2011. e-Pub 2010. PMID: 21170031.
- Lazarevic V, Chen X, Shim JH, Hwang ES, Jang E, Bolm AN, Oukka M, Kuchroo VK, Glimcher LH. T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt. Nat Immunol 12(1):96-104, 2011. e-Pub 2010. PMID: 21151104.
- Martinon F, Chen X, Lee AH, Glimcher LH. TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol 11(5):411-8, 2010. e-Pub 2010. PMID: 20351694.
- Chen X, Fang F, Liou YC, Ng HH. Zfp143 regulates Nanog through modulation of Oct4 binding. Stem Cells 26(11):2759-67, 2008. e-Pub 2008. PMID: 18687992.
- Chen X, Xu H, Yuan P, Fang F, Huss M, Vega VB, Wong E, Orlov YL, Zhang W, Jiang J, Loh YH, Yeo HC, Yeo ZX, Narang V, Govindarajan KR, Leong B, Shahab A, Ruan Y, Bourque G, Sung WK, Clarke ND, Wei CL, Ng HH. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133(6):1106-17, 2008. PMID: 18555785.
- Chen X, Vega VB, Ng HH. Transcriptional regulatory networks in embryonic stem cells. Cold Spring Harb Symp Quant Biol 73:203-9, 2008. e-Pub 2008. PMID: 19022762.
- Wu Q, Chen X, Zhang J, Loh YH, Low TY, Zhang W, Zhang W, Sze SK, Lim B, Ng HH. Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells. J Biol Chem 281(34):24090-4, 2006. e-Pub 2006. PMID: 16840789.
- Loh YH, Wu Q, Chew JL, Vega VB, Zhang W, Chen X, Bourque G, George J, Leong B, Liu J, Wong KY, Sung KW, Lee CW, Zhao XD, Chiu KP, Lipovich L, Kuznetsov VA, Robson P, Stanton LW, Wei CL, Ruan Y, Lim B, Ng HH. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet 38(4):431-40, 2006. e-Pub 2006. PMID: 16518401.
Book Chapters
- Zhao N, Peng F, Chen X. The Unfolded Protein Response in Triple-Negative Breast Cancer. In: Cancer Drug Discovery and Development. Humana Press: Switzerland, 133-161, 2019.
Patient Reviews
CV information above last modified April 18, 2024