Xue Hao, Ph.D.
Department of Experimental Therapeutics, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2015 | Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, CHN, PHD, Zoology |
| 2011 | Nanjing Agriculture University, Nanjing, CHN, MS, Zoology |
| 2009 | Nanjing Agriculture University, Nanjing, CHN, BS, Applied Chemistry |
Postgraduate Training
| 2023-2024 | Postdoctoral Fellow, The University of Texas MD Anderson Cancer Center, Houston, TX |
| 2019-2023 | Postdoctoral Fellow, The Wistar Institute, Philadelphia, PA |
| 2016-2019 | Research Associate, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming |
Honors & Awards
| 2022 | The Wistar Inclusion, Diversity & Equity Travel Award, The Wistar Institute |
| 2018 | Excellent Employee of the Year, Kunming Institute of Zoology |
| 2012 | Outstanding Master’s Graduate Award, Nanjing Agriculture University |
Selected Publications
Peer-Reviewed Articles
- Hao X, Zhao B, Towers M, Liao L, Monteiro EL, Xu X, Freeman C, Peng H, Tang HY, Havas A, Kossenkov AV, Berger SL, Adams PD, Speicher DW, Schultz D, Marmorstein R, Zaret KS, Zhang R. TXNRD1 drives the innate immune response in senescent cells with implications for age-associated inflammation. Nat Aging 4(2):185-197, 2024. e-Pub 2024. PMID: 38267705.
- Elbasir A, Ye Y, Schäffer DE, Hao X, Wickramasinghe J, Tsingas K, Lieberman PM, Long Q, Morris Q, Zhang R, Schäffer AA, Auslander N. A deep learning approach reveals unexplored landscape of viral expression in cancer. Nat Commun 14(1):785, 2023. e-Pub 2023. PMID: 36774364.
- Wang C, Hao X, Zhang R. Targeting cellular senescence to combat cancer and ageing. Mol Oncol 16(18):3319-3332, 2022. e-Pub 2022. PMID: 35674055.
- Hao X, Shiromoto Y, Sakurai M, Towers M, Zhang Q, Wu S, Havas A, Wang L, Berger S, Adams PD, Tian B, Nishikura K, Kossenkov AV, Liu P, Zhang R. ADAR1 downregulation by autophagy drives senescence independently of RNA editing by enhancing p16INK4a levels. Nat Cell Biol 24(8):1202-1210, 2022. e-Pub 2022. PMID: 35851616.
- Hao X, Wang C, Zhang R. Chromatin basis of the senescence-associated secretory phenotype. Trends Cell Biol 32(6):513-526, 2022. e-Pub 2022. PMID: 35012849.
- Liu P, Li F, Lin J, Fukumoto T, Nacarelli T, Hao X, Kossenkov AV, Simon MC, Zhang R. m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype. Nat Cell Biol 23(4):355-365, 2021. e-Pub 2021. PMID: 33795874.
- Hao X, Zhao B, Zhou W, Liu H, Fukumoto T, Gabrilovich D, Zhang R. Sensitization of ovarian tumor to immune checkpoint blockade by boosting senescence-associated secretory phenotype. iScience 24(1):102016, 2021. e-Pub 2020. PMID: 33490922.
- Shen C, Liu M, Tian H, Li J, Xu R, Mwangi J, Lu Q, Hao X, Lai R. Conformation-Specific Blockade of αIIbβ3 by a Non-RGD Peptide to Inhibit Platelet Activation without Causing Significant Bleeding and Thrombocytopenia. Thromb Haemost 120(10):1432-1441, 2020. e-Pub 2020. PMID: 32717755.
- Nacarelli T, Zhao B, Hao X, Zhang R. ARID1A mutation and genomic stability. Mol Cell Oncol 7(3):1690923, 2020. e-Pub 2020. PMID: 32391414.
- Mwangi J, Hao X, Lai R, Zhang ZY. Antimicrobial peptides: new hope in the war against multidrug resistance. Zool Res 40(6):488-505, 2019. PMID: 31592585.
- Chen R, Yuan L, Cao N, Li P, Chen H, Zhou J, Hao X, Liu T, Yang WH, Cui S, Yan X. An immunosuppressive peptide from the horsefly inhibits inflammation by repressing macrophage maturation and phagocytosis. J Cell Biochem 120(8):14116-14126, 2019. e-Pub 2019. PMID: 30977239.
- Jin L, Guo X, Shen C, Hao X, Sun P, Li P, Xu T, Hu C, Rose O, Zhou H, Yang M, Qin CF, Guo J, Peng H, Zhu M, Cheng G, Qi X, Lai R. Salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-β receptor. Nat Immunol 19(4):342-353, 2018. e-Pub 2018. PMID: 29507355.
- Hao X, Tang X, Luo L, Wang Y, Lai R, Lu Q. A novel ranacyclin-like peptide with anti-platelet activity identified from skin secretions of the frog Amolops loloensis. Gene 576(1 Pt 1):171-5, 2016. e-Pub 2015. PMID: 26449399.
- Hao X, Yang H, Wei L, Yang S, Zhu W, Ma D, Yu H, Lai R. Amphibian cathelicidin fills the evolutionary gap of cathelicidin in vertebrate. Amino Acids 43(2):677-85, 2012. e-Pub 2011. PMID: 22009138.
- Wang C, Tanizawa H, Hill C, Havas A, Zhang Q, Liao L, Hao X, Lei X, Wang L, Hao N, Qi Y, Tian B, Gardini A, Kossenkov AV, Goldman A, Berger SL, Noma K, Adams PD, Zhang R. METTL3-mediated chromain contacts promote phase separation through metabolic reprogramming during senescence. Nature Communications.
Grant & Contract Support
| Title: | Targeting the novel TXNRD1-cGAS-SASP axis to eradicate stem-like cells in epithelial ovarian cancer |
| Funding Source: | Department of Defense (DOD) |
| Role: | Principal Investigator |
Patient Reviews
CV information above last modified May 14, 2024