Zhen Lu, MD

Peer-Reviewed Articles

1. Zhou J, Alfraidi A, Zhang S, Santiago-O'Farrill JM, Yerramreddy Reddy VK, Alsaadi A, Ahmed AA, Yang H, Liu J, Mao W, Wang Y, Takemori H, Vankayalapati H, Lu Z, Bast RC. A novel compound ARN-3236 inhibits Salt Inducible Kinase 2 and sensitizes ovarian cancer cell lines and xenografts to paclitaxel. Clin Cancer Res 23(8):1945-1954, 2017. e-Pub 2016. PMID: 27678456.
2. Ornelas A, McCullough CR, Lu Z, Zacharias NM, Kelderhouse LE, Gray J, Yang H, Engel BJ, Wang Y, Mao W, Sutton MN, Bhattacharya PK, Bast RC, Millward SW. Induction of autophagy by ARHI (DIRAS3) alters fundamental metabolic pathways in ovarian cancer models. BMC Cancer 16(1):824, 2016. e-Pub 2016. PMID: 27784287.
3. Simmons AR, Clarke CH, Badgwell DB, Lu Z, Sokoll LJ, Lu KH, Zhang Z, Bast RC, Skates SJ. Validation of a Biomarker Panel and Longitudinal Biomarker Performance for Early Detection of Ovarian Cancer. Int J Gynecol Cancer 26(6):1070-7, 2016. PMID: 27206285.
4. Santiago-O’Farrill JM, Lu Z, Bast RC. Autophagy and Cancer Chemotherapy: Inhibition or Enhancement?. Single Cell Biol 5(145), 2016.
5. Ejaz A, Mitterberger MC, Lu Z, Mattesich M, Zwierzina ME, Hörl S, Kaiser A, Viertler HP, Rostek U, Meryk A, Khalid S, Pierer G, Bast RC, Zwerschke W. Weight Loss Upregulates the Small GTPase DIRAS3 in Human White Adipose Progenitor Cells, Which Negatively Regulates Adipogenesis and Activates Autophagy via Akt-mTOR Inhibition. EBioMedicine 6:149-61, 2016. e-Pub 2016. PMID: 27211557.
6. Morgado M, Sutton MN, Simmons M, Warren CR, Lu Z, Constantinou PE, Liu J, Francis LL, Conlan RS, Bast RC, Carson DD. Tumor necrosis factor-α and interferon-γ stimulate MUC16 (CA125) expression in breast, endometrial and ovarian cancers through NFκB. Oncotarget 7(12):14871-84, 2016. PMID: 26918940.
7. Yang H, Das P, Yu Y, Mao W, Wang Y, Baggerly K, Wang Y, Marquez RT, Bedi A, Liu J, Fishman D, Lu Z, Bast RC. NDN is an Imprinted Tumor Suppressor Gene that is Downregulated in Ovarian Cancers through Genetic and Epigenetic Mechanisms. Oncotarget 7(3):3018-32, 2016. PMID: 26689988.
8. Washington MN, Suh G, Orozco AF, Sutton MN, Yang H, Wang Y, Mao W, Millward S, Ornelas A, Atkinson, N, Liao WS, Bast RC Jr and Lu Z. ARHI (DIRAS3)-Mediated Autophagy Associated Cell Death Enhances Chemosensitivity to Cisplatin in Ovarian Cancer Cell Lines and Xenografts. Cell Death and Disease 6, 2015.
9. Zhang S*, Lu Z*, Mao W, Ahmed AA, Yang H, Zhou J, Jennings N, Rodriguez-Aguayo C, Lopez-Berestein G, Miranda R, Qiao W, Baladandayuthapani V, Li Z, Sood AK, Liu J, Le XF, Bast RC. CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis. PLoS One 10(7):e0131833, 2015. e-Pub 2015. PMID: 26146988.
10. Zhang S, Lu Z, Unruh AK, Ivan C, Baggerly KA, Calin GA, Li Z, Bast RC, Le XF. Clinically Relevant microRNAs in Ovarian Cancer. Mol Cancer Res. e-Pub 2014. PMID: 25304686.
11. Lu Z, Yang H, Sutton MN, Yang M, Clarke CH, Liao WS, Bast RC. ARHI (DIRAS3) Induces Autophagy in Ovarian Cancer Cells by Downregulating the Epidermal Growth Factor Receptor, Inhibiting PI3K and Ras/MAP Signaling and Activating the FOXo3a-Mediated Induction of Rab7. Cell Death Differ 21(8):1275-89, 2014. e-Pub 2014. PMID: 24769729.
12. Lu Z, Baquero MT, Yang H, Yang M, Reger AS, Kim C, Levine DA, Clarke CH, Liao WS, Bast RC. DIRAS3 Regulates the Autophagosome Initiation Complex in Dormant Ovarian Cancer Cells. Autophagy 10(6):1071-92, 2014. PMID: 24879154.
13. Lyu T, Jia N, Wang J, Yan X, Yu Y, Lu Z, Bast RC, Hua K, Feng W. Expression and Epigenetic Regulation of Angiogenesis-Related Factors During Dormancy and Recurrent Growth of Ovarian Carcinoma. Epigenetics 8(12):1330-46, 2013. e-Pub 2013. PMID: 24135786.
14. Lu Z, Bast RC. The Tumor Suppressor Gene ARHI (DIRAS3) Inhibits Ovarian Cancer Cell Migration through Multiple Mechanisms. Cell Adh Migr 7(2):232-6, 2013. e-Pub 2013. PMID: 23357870.
15. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Cho. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy. Autophagy 8(4):445-544, 2012. PMID: 22966490.
16. Badgwell DB*, Lu Z*, Le K, Gao F, Yang M, Suh GK, Bao JJ, Das P, Andreeff M, Chen W, Yu Y, Ahmed AA, S-L Liao W, Bast RC. The Tumor-Suppressor Gene ARHI (DIRAS3) Suppresses Ovarian Cancer Cell Migration through Inhibition of the Stat3 and FAK/Rho Signaling Pathways. Oncogene 31(1):68-79, 2012. e-Pub 2011. PMID: 21643014.
17. Auzenne EJ, Klostergaard J, Mandal PK, Liao WS, Lu Z, Gao F, Bast RC, Robertson FM, McMurray JS. A Phosphopeptide Mimetic Prodrug Targeting the SH2 Domain of Stat3 Inhibits Tumor Growth and Angiogenesis. J Exp Ther Oncol 10(2):155-62, 2012. PMID: 23350355.
18. Chen MY, Liao WS, Lu Z, Bornmann WG, Hennessey V, Washington MN, Rosner GL, Yu Y, Ahmed AA, Bast RC. Decitabine and Suberoylanilide Hydroxamic Acid (SAHA) Inhibit Growth of Ovarian Cancer Cell Lines and Xenografts while Inducing Expression of Imprinted Tumor Suppressor Genes, Apoptosis, G2/M Arrest, and Autophagy. Cancer 117(19):4424-38, 2011. PMID: 21491416.
19. Ahmed AA, Wang X, Lu Z, Goldsmith J, Le XF, Grandjean G, Bartholomeusz G, Broom B, Bast RC. Modulating Microtubule Stability Enhances the Cytotoxic Response of Cancer Cells to Paclitaxel. Cancer Res 71(17):5806-17, 2011. e-Pub 2011. PMID: 21775522.
20. Mandal PK, Gao F, Lu Z, Ren Z, Ramesh R, Birtwistle JS, Kaluarachchi KK, Chen X, Bast RC, Liao WS, McMurray JS. Potent and Selective Phosphopeptide Mimetic Prodrugs Targeted to the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3. J Med Chem 54(10):3549-63, 2011. e-Pub 2011. PMID: 21486047.
21. Zou CF, Jia L, Jin H, Yao M, Zhao N, Huan J, Lu Z, Bast RC, Feng Y, Yu Y. Re-expression of ARHI (DIRAS3) Induces Autophagy in Breast Cancer Cells and Enhances the Inhibitory Effect of Paclitaxel. BMC Cancer 11:22, 2011. e-Pub 2011. PMID: 21244707.
22. Le XF, Mao W, Lu Z, Carter BZ, Bast RC. Dasatinib Induces Autophagic Cell Death in Human Ovarian Cancer. Cancer 116(21):4980-90, 2010. PMID: 20629079.
23. Ahmed AA, Lu Z, Jennings NB, Etemadmoghadam D, Capalbo L, Jacamo RO, Barbosa-Morais N, Le XF, Australian Ovarian Cancer Study Group, Vivas-Mejia P, Lopez-Berestein G, Grandjean G, Bartholomeusz G, Liao W, Andreeff M, Bowtell D, Glover DM, Sood AK, Bast RC. SIK2 is a Centrosome Kinase Required for Bipolar Mitotic Spindle Formation that Provides a Potential Target for Therapy in Ovarian Cancer. Cancer Cell 18(2):109-21, 2010. PMID: 20708153.
24. Huang S, Chang IS, Lin W, Ye W, Luo RZ, Lu Z, Lu Y, Zhang K, Liao WS, Tao T, Bast RC, Chen X, Yu Y. ARHI (DIRAS3), an Imprinted Tumor Suppressor Gene, Binds to Importins and Blocks Nuclear Import of Cargo Proteins. Biosci Rep 30(3):159-68, 2010. e-Pub 2009. PMID: 19435463.
25. Xie X, Hsu JL, Choi MG, Xia W, Yamaguchi H, Chen CT, Trinh BQ, Lu Z, Ueno NT, Wolf JK, Bast RC, Hung MC. A Novel hTERT Promoter-Driven E1A Therapeutic for Ovarian Cancer. Mol Cancer Ther 8(8):2375-82, 2009. e-Pub 2009. PMID: 19671744.
26. Cheon DJ, Wang Y, Deng JM, Lu Z, Xiao L, Chen CM, Bast RC, Behringer RR. CA125/MUC16 is Dispensable for Mouse Development and Reproduction. PLoS One 4(3):e4675, 2009. e-Pub 2009. PMID: 19262696.
27. Lu Z, Luo RZ, Lu Y, Zhang X, Yu Q, Khare S, Kondo S, Kondo Y, Yu Y, Mills GB, Liao WS, Bast RC. The Tumor Suppressor Gene ARHI Regulates Autophagy and Tumor Dormancy in Human Ovarian Cancer Cells. J Clin Invest 118(12):3917-29, 2008. e-Pub 2008. PMID: 19033662.
28. Wang Y, Cheon DJ, Lu Z, Cunningham SL, Chen CM, Luo RZ, Xing D, Orsulic S, Bast RC, Behringer RR. MUC16 Expression During Embryogenesis, in Adult Tissues, and Ovarian Cancer in the Mouse. Differentiation 76(10):1081-92, 2008. e-Pub 2008. PMID: 18637025.
29. Moore RG, Brown AK, Miller MC, Badgwell D, Lu Z, Allard WJ, Granai CO, Bast RC, Lu K. Utility of a Novel Serum Tumor Biomarker HE4 in Patients with Endometrioid Adenocarcinoma of the Uterus. Gynecol Oncol 110(2):196-201, 2008. e-Pub 2008. PMID: 18495222.
30. Feng W, Marquez RT, Lu Z, Liu J, Lu KH, Issa JP, Fishman DM, Yu Y, Bast RC. Imprinted Tumor Suppressor Genes ARHI and PEG3 are the Most Frequently Down-Regulated in Human Ovarian Cancers by Loss of Heterozygosity and Promoter Methylation. Cancer 112(7):1489-502, 2008. PMID: 18286529.
31. Badgwell D, Lu Z, Cole L, Fritsche H, Atkinson EN, Somers E, Allard J, Moore RG, Lu KH, Bast RC. Urinary Mesothelin Provides Greater Sensitivity for Early Stage Ovarian Cancer than Serum Mesothelin, Urinary hCG Free Beta Subunit and Urinary hCG Beta Core Fragment. Gynecol Oncol 106(3):490-7, 2007. e-Pub 2007. PMID: 17532030.
32. Feng W, Lu Z, Luo RZ, Zhang X, Seto E, Liao WS, Yu Y. Multiple Histone Deacetylases Repress Tumor Suppressor Gene ARHI in Breast Cancer. Int J Cancer 120(8):1664-8, 2007. PMID: 17230502.
33. Bast RC, Brewer M, Zou C, Hernandez MA, Daley M, Ozols R, Lu K, Lu Z, Badgwell D, Mills GB, Skates S, Zhang Z, Chan D, Lokshin A, Yu Y. Prevention and early Detection of Ovarian Cancer: Mission Impossible?. Recent Results Cancer Res 174:91-100, 2007. PMID: 17302189.
34. Le XF, Bedrosian I, Mao W, Murray M, Lu Z, Keyomarsi K, Lee MH, Zhao J, Bast RC. Anti-HER2 Antibody Trastuzumab Inhibits CDK2-Mediated NPAT and Histone H4 Expression via the PI3K Pathway. Cell Cycle 5(15):1654-61, 2006. e-Pub 2006. PMID: 16861913.
35. Lu Z, Luo RZ, Peng H, Rosen DG, Atkinson EN, Warneke C, Huang M, Nishmoto A, Liu J, Liao WS, Yu Y, Bast RC. Transcriptional and Posttranscriptional Down-Regulation of the Imprinted Tumor Suppressor Gene ARHI (DRAS3) in Ovarian Cancer. Clin Cancer Res 12(8):2404-13, 2006. PMID: 16638845.
36. Yu Y, Luo R, Lu Z, Wei Feng W, Badgwell D, Issa JP, Rosen DG, Liu J, Bast RC. Biochemistry and Biology of ARHI (DIRAS3), an Imprinted Tumor Suppressor Gene whose Expression is Lost in Ovarian and Breast Cancers. Methods Enzymol 407:455-68, 2006. PMID: 16757345.
37. Lu Z, Luo RZ, Peng H, Huang M, Nishmoto A, Hunt KK, Helin K, Liao WS, Yu Y. E2F-HDAC Complexes Negatively Regulate the Tumor Suppressor Gene ARHI in Breast Cancer. Oncogene 25(2):230-9, 2006. PMID: 16158053.
38. Nishimoto A, Yu Y, Lu Z, Mao X, Ren Z, Watowich SS, Mills GB, Liao WS, Chen X, Bast RC, Luo RZ. A Ras Homologue Member I Directly Inhibits Signal Transducers and Activators of Transcription 3 Translocation and Activity in Human Breast and Ovarian Cancer Cells. Cancer Res 65(15):6701-10, 2005. PMID: 16061651.
39. Wang L, Hoque A, Luo RZ, Yuan J, Lu Z, Nishimoto A, Liu J, Sahin AA, Lippman SM, Bast RC, Yu Y. Loss of the Expression of the Tumor Suppressor Gene ARHI is Associated with Progression of Breast Cancer. Clin Cancer Res 9(10 Pt 1):3660-6, 2003. PMID: 14506155.
40. Chung K-T, Lu Z, Chow MW.. Mechanism of Inhibition of Tannic Acid and Related Compounds on Growth of Intestinal Bacteria. Food and Chemical Toxicology(36):1053-1060, 1998.
41. Kong Q, Lu Z.. Observation on Cellular Kinetics in Experimental Mouse Colon Carcinoma. Acta Academic Medicine Suzhou:166-168, 1992.
42. Lu Z, Zhang P, Mao D.. Experimental Studies for Murine Colon Cancer Induced by GMM. Acta Academic Medicine Suzhou(11):24-29, 1991.

Abstracts

1. Yang WL, Simmons A, Lu Z, Baggerly K, Lu K. TP53 Autoantibody Can Detect CA125 Screen Negative Ovarian Cancer Cases and Can be Elevated Prior to CA125 in Preclinical Ovarian Cancer. Proc Amer Assoc Cancer Res, 2015.
2. Morgado M, Sutton MN, Simmons M, Liu J, Lu Z, Papadppoulos PE, Bast RC, Jr, Carson DD. MC16/CA!25, TNFα and IFN-γ are Co-Expressed in Malignant Gynecologic Neoplasms. Proc Amer Assoc Cancer Res, 2015.
3. Lu Z, Mao W, Wang Y, Levine DA, Bast RC. Jr. ARHI plays a critical role in ovarian cancer tumor dormancy by inhibition of angiogenesis switch. Proc Amer Assoc Cancer Res, 2015.
4. Lu Z, Orozco AF, Sutton MN, Wang Y, Mao W, Bast RC. IL8, VEGF and IGF-1 Rescue Ovarian Cancer Cells Undergoing ARHI-Mediated-Autophagic Cell Death. Proc Amer Assoc Cancer Res, 2015.
5. Yang H, Das P, Yu Y, Mao W, Marquez R T, Lu Z and Bast RC, Jr. NDN, an Imprinted Tumor Suppressor Gene Inhibits Ovarian Cancer Cell Motility in Ovarian Cancer by Deactivating FAK and RhoA. Proc Amer Assoc Cancer Res, 2015.
6. Sutton M, Lu Z, Gomez S, Fu C, Bast RC Jr. ARHI (DIRAS3) Downregulates Ras-MAPK Signaling and Inhibits Transformation of NIH3T3 Cells through Direct Interaction with GTP-Bound Ras. Proc Amer Assoc Cancer Res, 2014.
7. Yang H*, Das P*, Yu Y, Baggerly K, Wang Y, Mao W, Marquez RT, Lu Z, Liu J, Bast RC Jr. NDN, an Imprinted Tumor Suppressor Gene, Inhibits Ovarian Cancer Cell Growth and Motility and is Downregulated by Genetic and Epigenetic Mechanisms. Proc Amer Assoc Cancer Res, 2014.
8. Alfredi A*, Zhang S*, Mao W, Wang Y, Takemori H, Bast, RC Jr**, Lu Z**, Vankayalapati H**.. Highly Potent and Orally Available SIK2 Inhibitors Block Growth of Human Ovarian Cancer Cells in Culture and Xenografts. Proc Amer Assoc Cancer Res, 2014.
9. Bast RC Jr, Sutton MN, Gomez S, Fu C, Pontrakis M, Lu Z. The role of the Imprinted Tumor Suppressor Gene DIRAS3 (ARHI) in Regulating Ovarian Cancer Cell Growth, Motility, Autophagy and Tumor Dormancy. 1st Annual Meeting of the International Ovarian Cancer Consortium: Tumor Microenvironment and Drug Discovery, 2014.
10. Liu Y, Tao X, Zhang Z, Jin H, Lu Y, Lu Z, Bast RC Jr, Feng Y, Yu Y. Follicle-Stimulating Hormone Inhibits Apoptosis and Autophagy in Ovarian Cancer Cells by Activating Multiple Signaling Pathways. Gordon Research Conference on Autophagy in Stress, Development and Disease, 2014.
11. Morgado M, Sutton M, Simmons M, Lu Z, Bast RC Jr, Carson D. Cytokine Stimulation of MUC16 Expression in Human Endometrial and Ovarian Epithelial Cell Lines. Endocrine Society, 2013.
12. Raamanathan A, Lu Z, Bast RC Jr*, Skates SJ*.. Intra-person and Inter-person biomarker variation for modeling longitudinal values of ovarian cancer early detection biomarkers. Proc Amer Assoc Cancer Res, 2013.
13. Yang H, Wang X, Ahmed AA, Lu Z, Bast RC Jr. Knockdown of Kinases that Regulate Microtubule Stability and Centrosome Function Enhance Paclitaxel Sensitivity in Multiple Ovarian Cancer Cell Lines. Proc Amer Assoc Cancer Res, 2013.
14. Washington MN*, Suh G, Orosco AF*, Yang M, Wang W, Gao F, Atkinson EN, Liao W, Lu Z, Bast RC Jr. ARHI-Induced Autophagy Enhances Chemosensitivity to Cisplatin in Human Ovarian Cancer Cell Lines and Xenografts. Proc Amer Assoc Cancer Res, 2013.
15. Sutton MN, Lu Z, Bast RC. ARHI (DIRAS3) Family Members Inhibit Cell Growth and Proliferation While Inducing Autophagy in Human Ovarian Cancer Cells. Proc Amer Assoc Cancer Res, 2013.
16. Lu Z, Liao WSL, Yang M, Gao F, Bast RC Jr.. ARHI Downregulates PI3K and Ras-MAP Signaling and Induces Autophagy by Promoting Integrin and EGFR Membrane Protein Degradation. Proc Amer Assoc Cancer Res. Proc Amer Assoc Cancer Res, 2012.
17. Bast RC Jr, Lokshin A, Skates S, Zhang Z, Lu Z, Baggerly K, Atkinson JN, Diao L, He WW, Bedi DG, Bevers T, Adeyinka O, Newland W, Moore R, Leeds L, Harris S, Fritsche H, Lu KH.. Early Detection of Ovarian Cancer: The MDACC Ovarian SPORE Trial and Development of Strategies to Detect Preclinical Disease. Helene Harris Memorial Trust, 2011.
18. Yu Y, Lu Z, Das P, Yang H, Feng W, Chen M, Bast RC Jr. Multiple Imprinted Tumor Suppressor Genes in Ovarian Cancer. ICC Course on "Genomic imprinting and beyond – Monoallelic expression in health and disease, 2011.
19. Zhang Z, Skates SJ, Sokoll LJ, Lu Z, Clarke CH, Hernandez MA, Lu KH, Bast RC. A Multivariate Longitudinal Algorithm for Early Detection of Ovarian Cancer Using Multiple Biomarkers. Proc Amer Soc Clin Oncol 29, 2011.
20. Liao W, Lu Z, Gao F, Yang M, Bast RC Jr. ARHI-Induced Autophagy is Mediated through Activation of FoxO3a and Induction of its Target Genes to Promote the Formation of Autophagic Complexes. Proc Amer Assoc Cancer Res 52, 2011.
21. Ahmed AA, Le XF, Lu Z, Mao M, Aiken A, Bast RC Jr. Loss of CDK5 Sensitizes Cells to Paclitaxel by Enhancing Intracellular Retention. Proc Amer Assoc Cancer Res 51, 2010.
22. Mandal PK, Liao W, Gao F, Robertson F, Thudi N, Ekmekcioglu S, Chattopadhyay C, Ren Z, Chen X, Lu Z, Bast RC Jr, McMurray JS. Potent, Highly Specific Peptidomimetic Targeting the SH2 Domain of Stat3 Decreases Vasculogenic Mimicry, Invasion and Anchorage Independent Growth of Cancer Cells. Proc Amer Assoc Cancer Res 51, 2010.
23. Lu Z, Liao WSL, Bast RC Jr.. ARHI is Required for Induction of Beclin-1/PI(3)K Class III-Mediated Autophagy. Proc Amer Assoc Cancer Res 51, 2010.
24. Lu Z, Liao WSL, Suh GL, Bast RC Jr. Integrin and FAK Signaling Regulate ARHI-Induced Autophagy. Proc Amer Assoc Cancer Res 51, 2010.
25. Bast RC Jr, Skates S, Zhang Z, Coombes K, Atkinson EN, Lokshin A, Clarke C, Lu Z, Zheng JF, Das P, Badgwell D, Celestino J, Hernandez MA, Moore R, Granai C, Newland W, Shadur C, Adeyinka O, Harris SA, Fung E, Allard J, Somers E, Fritsche H, Menon U, Jacobs I, Lu KH. Early Detection of Ovarian Cancer: An Update. 7th International Symposium on Advanced Ovarian Cancer, 2009.
26. Liao W, Lu Z, Elizondo S, Suh GK, Bast RC. ARHI-induced Autophagy is Mediated through Transcription Factor FoxO3a and Can be Rescued by Growth Factors. Proc Amer Assoc Cancer Res 50, 2009.
27. Liao W, Lu Z, Elizondo S, Suh GK, Bast RC. ARHI-Induced Autophagy is Mediated through Transcription Factor FoxO3a and Can be Rescued by Growth Factors. Proc Amer Assoc Cancer Res 50, 2009.
28. Le XF, Mao W, Lu Z, Bast RC. Dasatinib Induces Autophagy as well as Growth Arrest in Human Ovarian Cancer Cells. Proc Amer Assoc Cancer Res 50, 2009.
29. Ahmed A, Le XF, Lu Z, Bast RC. Kinase Regulated Microtubule Stabilization Correlates with Paclitaxel Response in a Target Specific siRNA Kinome Screen. Proc Amer Assoc Cancer Res 50, 2009.
30. Lu Z, Badgwell DB, Le K, Suh GK, Das P, Andreeff M, Ahmed A, Liao WS, Bast RC. Re-Expression of the Tumor Suppressor Gene ARHI Suppresses Ovarian Cancer Cell Motility through Inhibition of Stat3 and the Rho/ROCK Signaling. Proc Amer Assoc Cancer Res 50, 2009.
31. Ahmed A, Jacomo RO, Lu Z, Das P, Zheng JF, Liao W, Andreeff M, Bast RC. The Salt Inducible Kinase 2 (SIK2) is Required for Centrosome Separation at the Onset of Mitosis. Proc Amer Assoc Cancer Res 50, 2009.
32. Bast RC Jr, Skates S, Zhang Z, Coombes K, Baggerly K, Atkinson EN, Lokshin A, Clarke C, Lu Z, Zheng JF, Das P, Badgwell D, Celestino J, Hernandez MA, Moore R, Granai C, Newland N, Shadur C, Adeyinka O, Harris SA, Fung E, Allard J, Somers E, Fritsche H, Menon U, Jacobs I, Lu K. Optimizing a Two-Stage Strategy for Early Detection of Ovarian Cancer. NCI Translates. NCI Translational Science Meeting 300, 2008.
33. Lu Z, Liao W. Yu Y, Le Kim, Elizondo S, Cheng KW, Lu Y, Luo RZ, Kondo S, Mills GB, Bast RC Jr. Tumor Suppressor Gene ARHI (DIRAS3) is Required for Spontaneous and Repamycin-Induced Autophagy in Normal and Ovarian Cell. Proc Amer Assoc Cancer Research, 2008.
34. Das P, Lu Z, Bedi A, Marquez R, Atashroo D, Yu Yinhua, Bast RC Jr. Downregulation of Multiple Imprinted Gene in Ovarian Cancer. Proc Amer Assoc Cancer Research 433, 2008.
35. Yu Y, Hu X, Huang S, Lu Z, Luo R, Liao W, Qin X-F, Bast RC Jr. Knockdown of ARHI Promotes the Proliferation of Normal Breast and Ovarian Epithelial Cells and Enhances Breast Cancer Growth. Proc Amer Assoc Cancer Res 49, 2008.
36. Lu Z, Liao W S-L, Yu Y, Le K, Elizondo S, Cheng KW, Lu Y, Luo R, Kondo S, Mills GB, Bast RC Jr. Tumor Suppressor Gene ARHI (DIRAS3) is Required for Spontaneous and Rapamycin-Induced Autophagy in Normal and Ovarian Cancer Cells. Proc Amer Assoc Cancer Res 49, 2008.
37. Huang S, Chang IS, Luo RZ, Lu Z, Bast RC Jr, Chen X, Yu Y. The ARHI Tumor Suppressor Gene May Prevent Nuclear Translocation of p-STAT3 by Antagonizing the Interaction of Ran with Importin Proteins. Proc Amer Assoc Cancer Research, 2007.
38. Cheon D-J, Wang Y, Chen C-M, Lu Z, Luo RZ, Cunningham SL, Xing D, Orsulic S, Bast RC Jr, Behringer RR. Functional Studies of the Ovarian Cancer Antigen CA125 (Mucin 16) in the Mouse. Proc Amer Assoc Cancer Research, 2007.
39. Chen M-Y, Yu Y, Lu Z, Rosner GL, Atkinson EN, Fu S, Kavanagh J, Bast RC Jr. Synergistic Inhibition of Ovarian Cancer Cell Growth with Demethylating Agents and Histone Deacetylase Inhibitors. Proc Amer Assoc Cancer Research, 2007.
40. Badgwell D, Lu Z, Luo R, Yu Y, Bao J-J, Liao W, Bast RC Jr. Re-Expression of the Tumor Suppressor Gene ARHI Decreases Ovarian Cancer Cell Motility by Inhibiting STAT3 Signaling. Proc Amer Assoc Cancer Research, 2007.
41. Lu Z, Luo RZ, Zhang X, Yu Y, Bast RC Jr. A Novel Tumor Suppressor Gene ARHI (DIRAS3) Enhances Polymerization of Microtubules and Increases the Anti-Tumor Activity of Paclitaxel. Proc Amer Assoc Cancer Research, 2007.
42. Luo RZ, Lu Z, Lu Y, Zhang X, Yu Q, Khare S, Kondo S, Kondo Y, Yu Y, Liao W, Mills GB, Bast RC Jr. A Novel Tumor Suppressor Gene ARHI Induces Autophagy and Tumor Dormancy in Ovarian Cancer. Proc Amer Assoc Cancer Research, 2007.
43. Badgwell D, Lu Z, Fritsche H, Atkinson EN, Sommers E, Allard J, Moore R, Lu K and Bast RC, Jr. Soluble Mesothelin-Related Protein (SMRP) is Elevated in the Serum and Urine of Patients with Early Stage Ovarian Cancer. 10th Annual SPORE Workshop, 2006.
44. Moore RG, Brown AK, Miller MC, Badgwell D, Lu Z, Verch T, Allard WJ, Granai CO, Bast R, Lu K. Utility of a Novel Serum Tumor Biomarker HE4 in Patients with Uterine Cancer. Proc Amer Soc Clin Oncol 24, 2006.
45. Moore RG, Brown AK, Miller MC, Lu Z, Badgwell D, Verch T, Allard WJ, Lu K, Granai CO, Bast R. A Novel Multiple Biomarker Assay for the Detection of Ovarian Cancer. Proc Amer Soc Clin Oncol 24, 2006.
46. Luo R, Lu Z, Lu Y, Khare S, Kondo S, Kondo Y, Yu Y, Liao WS, Mills GB, Bast RC Jr. A novel Tumor Suppressor Gene ARHI Induces Autophagy in Ovarian Cancer. Proc Amer Assoc Cancer Res:#4094, 2006.
47. Lu Z, Luo R, Khare S, Wang Y, Cheon DJ, Chen CM, Behringer RR, Bast RC Jr. Distribution of Murine MUC16, a Homolog of Human Ovarian Cancer Marker CA125, in Adult Murine Reproductive Tissues. Proc Amer Assoc Cancer Res, 2006.
48. Feng W, Marquez RT, Lu Z, Liu J, Lu KH, Yu Y, Bast RC Jr. Genetic and Epigenetic Regulation of Two Imprinted Tumor Suppressor Genes – ARHI and PEG3 – in Ovarian Cancer. Proc Amer Assoc Cancer Res, 2006.
49. Bast RC Jr, Marquez R, Lu Z, Luo R, Bao J-J, Feng W, Rosen D, Liu J, Lu K, Mills G, Gershenson D, Liao W, Yu Y. Imprinted Tumor Suppressor Genes in Epithelial Ovarian Cancer. Helene Harris Memorial Trust 10th Biennial International Forum on Ovarian Cancer, 2005.
50. Luo R, Lu Z, Khare S, Yu Y, Bast RC Jr. Expression of the Tumor Suppressor Gene ARHI Induces Autophagic Cell Death in Ovarian Cancer Cells. Proc Amer Assoc Cancer Res 46:844, 2005.
51. Lu Z, Luo RZ, Khare S, Yu Y, Bast RC Jr. Inducible Expression of Tumor Suppressor Gene ARHI in Ovarian Cancer Cells Triggers G2M Arrest and Inhibits Cancer Cell Growth in Vitro and in Vivo. Proc Amer Assoc Cancer Res 46:2895, 2005.
52. Feng W, Lu Z, Luo R, Zhang X, Seto E, Bast RC Jr, Yu Y. The ARHI Tumor Suppressor Gene is Repressed by Multiple Histone Deacetylases (HDACs) in Breast Cancer. Proc Amer Assoc Cancer Res 46:2732, 2005.
53. Yu Y, Bao J-J, Fang B, Lu Z, Luo RZ, and Bast RC Jr. ARHI Gene Therapy and Paclitaxel Exert Additive Cytotoxicity for Breast Cancer Cells through Caspase-Independent and Caspase-Dependent Apoptotic Mechanisms. The 16th EORTC-NCI-AACR Symposium on "Molecular Targets and Cancer Therapeutics, 2004.
54. Yu Y, Lu Z, Luo RZ, Peng H, Nishmoto A, Huang M, Liao WS-L, and Bast RC Jr. Transcriptional Regulation of the Tumor Suppressor Gene ARHI by E2F-HDAC Complexes in Breast and Ovarian Cancers. Chromatin structure and gene expression mechanisms as therapeutic targets, 2004.
55. Lu Z, Luo RZ, Peng H, Nishimoto A, Huang M, Liao WS-L, Bast RC Jr, Yu Y.. E2F-HDAC Complexes Downregulate Expression of the Tumor Suppressor Gene ARHI in Breast Cancer Cell Lines. Proc Amer Assoc Cancer Res 45:809 (A#3508), 2004.
56. Nishimoto A, Yu Y, Lu Z, Ren Z, Mao X, Watowich SS, Mills GB, Liao W, Chen X, Bast RC Jr. ARHI Directly Inhibits STAT3 Translocation and Activity in Human Breast and Ovarian Cancer Cells. Proc Amer Assoc Cancer Res 45:412, 2004.
57. Nishimoto A, Yu Y, Lu Z, Liao, W S-L, Bast RC Jr, Luo RZ. A Novel Tumor Suppressor Gene Interacts with and Inhibits STAT3 Activity in Breast and Ovarian Cancer. Proteomics 3:80, 2004.
58. Lu Z, Luo RZ, Peng HX, Yu Y, Bast RC Jr. Transcriptional and Post-Transcriptional Regulation of the Imprinted Tumor Suppressor Gene ARHI in Breast and Ovarian Cancers. Proc Amer Assoc Cancer Res 44:1138, 2003.

Book Chapters

1. Sutton MN, Lu Z, Bast RC. The Role of Angiogenesis, Growth Arrest and Autophagy in Human Ovarian Cancer Xenograft Models for Tumor Dormancy. In: Tumor Dormancy, Quiescence, and Senescence. 1. Springer Netherlands, 99-109, 2014.
2. Lu Z, Bast RC. Tumor suppressor genes. In: Cancer Treat Res, 109-29, 2009.
3. Lu Z, Feng W, Luo RZ, Liao WSL, Bast RC Jr, Yu Y.. E2F-HADC complexes regulate tumor suppressor gene in cancer. In: Control of Cellular Physiology by E2F Transcription Factors: Kerala, India, 303-307, 2008.