Zhibin Zhang, Ph.D.
Department of Immunology, Division of Discovery Science
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Immunology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2014 | National Institute of Biological Sciences (NIBS), Beijing, CHN, PHD, Biochemistry and Molecular Biology |
| 2008 | Wuhan University, Wuhan, CHN, BS, Life Science and Biotechnology |
Postgraduate Training
| 2015-2019 | Research Fellowship, Boston Children's Hospital / Harvard Medical School, Boston, MA |
| 2014-2014 | Research Fellowship, University of North Carolina at Chapel Hill, Chapel Hill, NC |
Experience & Service
Academic Appointments
Instructor, Boston Children's Hospital / Harvard Medical School, Boston, MA, 2019 - 2021
Honors & Awards
| 2022 | UT System Rising STARs Award |
| 2020 | Harvard Chinese Life Science Distinguished Research Award |
| 2018 | Charles A. King Trust Postdoctoral Research Fellowship |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Deng W, Bai Y, Deng F, Pan Y, Mei S, Zheng Z, Min R, Wu Z, Li W, Miao R, Zhang Z, Kupper TS, Lieberman J, Liu X. Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis. Nature 602(7897):496-502, 2022. e-Pub 2022. PMID: 35110732.
- Xia S, Zhang Z, Magupalli VG, Pablo JL, Dong Y, Vora SM, Wang L, Fu TM, Jacobson MP, Greka A, Lieberman J, Ruan J, Wu H. Gasdermin D pore structure reveals preferential release of mature interleukin-1. Nature 593(7860):607-611, 2021. e-Pub 2021. PMID: 33883744.
- Zhang Z*#, Zhang Y*, Xia S, Kong Q, Li S, Liu X, Junqueira C, Meza-Sosa KF, Mok TMY, Ansara J, Sengupta S, Yao Y, Wu H, Lieberman J# (*Co-first authors, #Corresponding authors). Gasdermin E suppresses tumour growth by activating anti-tumour immunity. Nature 579(7799):415-420, 2020. e-Pub 2020. PMID: 32188940.
- Liu X, Fu R, Pan Y, Meza-Sosa KF, Zhang Z, Lieberman J. PNPT1 Release from Mitochondria during Apoptosis Triggers Decay of Poly(A) RNAs. Cell 174(1):187-201.e12, 2018. e-Pub 2018. PMID: 29779946.
- Zhang Z, Liu Y, Huang H, Gao M, Wu D, Kong Q, Zhang Y. The NLR protein SUMM2 senses the disruption of an immune signaling MAP kinase cascade via CRCK3. EMBO Rep 18(2):292-302, 2017. e-Pub 2016. PMID: 27986791.
- Liu X*, Zhang Z*, Ruan J*, Pan Y, Magupalli VG, Wu H, Lieberman J (*Co-first authors). Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature 535(7610):153-8, 2016. PMID: 27383986.
- Zhang Z, Liu Y, Ding P, Li Y, Kong Q, Zhang Y. Splicing of receptor-like kinase-encoding SNC4 and CERK1 is regulated by two conserved splicing factors that are required for plant immunity. Mol Plant 7(12):1766-75, 2014. e-Pub 2014. PMID: 25267732.
- Zhang Z, Wu Y, Gao M, Zhang J, Kong Q, Liu Y, Ba H, Zhou J, Zhang Y. Disruption of PAMP-induced MAP kinase cascade by a Pseudomonas syringae effector activates plant immunity mediated by the NB-LRR protein SUMM2. Cell Host Microbe 11(3):253-63, 2012. PMID: 22423965.
Invited Articles
- Liu X*#, Xia S*, Zhang Z*, Wu H#, Lieberman J# (*Co-first authors, #Corresponding authors). Channelling inflammation: gasdermins in physiology and disease. Nat Rev Drug Discov 20(5):384-405, 2021. e-Pub 2021. PMID: 33692549.
- Zhang Z, Zhang Y, Lieberman J. Lighting a Fire: Can We Harness Pyroptosis to Ignite Antitumor Immunity?. Cancer Immunol Res 9(1):2-7, 2021. PMID: 33397791.
- Zhang Z, Lieberman J. Lighting a fire on the reef. Sci Immunol 5(54), 2020. PMID: 33277372.
Patient Reviews
CV information above last modified February 21, 2024