Zhizhong Z. Pan, Ph.D.
Department of Pain Medicine, Division of Anesthesiology, Critical Care Medicine, and Pain Medicine
Present Title & Affiliation
Primary Appointment
Professor, Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Professor, Department of Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1993 | Vollum Institute and Department of Physiology, Oregon Health Sciences University, Portland, Oregon, US, Neuroscience, Ph.D |
| 1985 | Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai, CN, Physiology, Master of Science |
| 1982 | Jiangxi University, Jiangxi, CN, Biology, Bachelor of Science |
Postgraduate Training
| 1993-1997 | Postdoctoral Fellowship, Neuroscience, University of California at San Francisco, San Francisco, California |
Experience & Service
Faculty Academic Appointments
Associate Professor, Department of Pain Medicine, Division of Anesthesiology, Critical Care and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2006 - 2012
Faculty Member, The University of Texas Graduate School of Biomedical Sciences, Houston, TX, 2000 - 2012
Assistant Professor, Department of Anesthesiology, Division of Anesthesiology, Critical Care and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2000 - 2006
Adjunt Assistant Professor, Department of Neurology, University of California, San Francisco, CA, 1997 - 2000
Staff Research Associate, Vollum Institute, Oregon Health Sciences University, Portland, OR, 1987 - 1990
Assistant Investigator, Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai, 1986 - 1987
Staff Researcher, Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai, 1985 - 1986
Administrative Appointments/Responsibilities
Seminar Coordinator, The University of Texas MD Anderson Cancer Center, Houston, TX, 2005 - 2007
Intramural Institutional Committee Activities
Member, Annual Postdoctoral Science Symposium Reviews, The University of Texas MD Anderson Cancer Center, 2019
Member, Division Faculty Recruitment Committee, The University of Texas MD Anderson Cancer Center, 2018 - 2022
Member, Division Research Development Committee, The University of Texas MD Anderson Cancer Center, 2017 - 2023
Reviewer, Provost Distinguished Research Faculty Mentoring Award, The University of Texas MD Anderson Cancer Center, 2017
Member, Internal Review Study Section (INTEREST), The University of Texas MD Anderson Cancer Center, 2017
Member, Faculty Academic Review Committee, The University of Texas MD Anderson Cancer Center, 2015 - 2022
Reviewer, Endowed Fellowship Award Reviewer, The University of Texas MD Anderson Cancer Center, 2015 - 2017
Member, Executive Committee, Gulf Coast Consortium for Transnational Pain Research, The University of Texas MD Anderson Cancer Center, 2012 - 2018
Member, Thesis Supervisory Committee, GSBS for PhD Students, The University of Texas MD Anderson Cancer Center, 2012 - 2014
Member, Admission Committee, GSBS Neuroscience Program, The University of Texas MD Anderson Cancer Center, 2008 - 2014
Member, Division Research Committee, The University of Texas MD Anderson Cancer Center, 2006 - Present
Chair, Thesis Examining Committee, GSBS for PhD Students, The University of Texas MD Anderson Cancer Center, 2005 - Present
Member, Thesis Supervisory Committee, GSBS for PhD Students, The University of Texas MD Anderson Cancer Center, 2005 - 2009
Member, Institutional Animal Care and Use Committee (IACUC), The University of Texas MD Anderson Cancer Center, 2005 - 2008
Chair, Thesis Advisory Committee, Examining Committee for PhD Students, The University of Texas MD Anderson Cancer Center, 2005 - 2006
Extramural Institutional Committee Activities
Member, Thesis Advisory Committee, GSBS for PhD Students, The University of Texas MD Anderson Cancer Center, 2010 - 2017
Member, Thesis Advisory Committee, GSBS for PhD Students, The University of Texas MD Anderson Cancer Center, 2004 - 2006
Editorial Activities
Editor, Molecular Pain, 2004 - Present
Honors & Awards
| 1993 | National Research Service Award, NIH |
| 1991 | Oregon N.L. Tartar Research Award, State of Oregon |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2020. Impact of pain on opioid use. Invited. College Station, Texas, US.
- 2015. Pain and Opioids: From Gene to Behavior. Conference. Pain and Opioids: From Gene to Behavior. Houston, TX, US.
- 2014. Bridging the Gap Between Pain Research and Pain Managment. Conference. Bridging the Gap Between Pain Research and Pain Managment. Houston, Texas, US.
- 2007. Pain and Opioid Addiction. Conference. Pain and Opioid Addiction. Houston, Texas, US.
- 2006. Opioid Analgesics: Medical Use and Non-Medical Abuse. Conference. Opioid Analgesics: Medical Use and Non-Medical Abuse. Houston, Texas, US.
- 2005. Opioid Receptor Functions. Conference. Opioid Receptor Functions. Houston, TX, US.
- 2005. Chronic Opioid and Pain. Conference. Chronic Opioid and Pain. Houston, Texas, US.
- 2003. Mechanisms of Opioid Tolerance and Dependence. Conference. Mechanisms of Opioid Tolerance and Dependence. Houston, Texas, US.
- 2000. How Opioids Inhibit Pain. Conference. How Opioids Inhibit Pain. Houston, Texas, US.
National Presentations
- 2018. Brain Circuits for Emotion and Pain. Conference. Vollum Symposium. Portland, OR, US.
- 2016. Exploring the Epigenetic Mechanisms for Individual Pain Vulnerability. Conference. 8th Scientific Meeting of the TMJ Association with FASEB and NIDCR. Bethesda, MD, US.
- 2015. Dissecting the Brain's Pain Circuits. Conference. International Narcotics Research Conference. Phoenix, AZ, US.
- 2010. Signaling Mechanisms for DOR Trafficking and Function. Conference. Spring Pain Research Conference. Grand Cayman.
- 2006. Central Amygdala in Drug Addiction and Pain Modulation. Conference. Annual meeting of American Pain Society. San Antonio, TX, US.
- 2006. Central Amygdala Function in Pain modulation. Conference. Spring Pain Research Conference. Grand Cayman.
International Presentations
- 2019. Epigenetic Mechanisms of Pain vulnerability. Invited. Xuzhou, CN.
- 2015. Targeting Brain Circuits for Pain and Emotion. Conference. 6th Asian Pain Conference. Suzhou, CN.
- 2014. Repression mechanisms in epigenetic regulation of pain. Conference. 15th Congress on Pain. Buenos Aires, AR.
- 2014. Pain Increases Reward Response to Opioids through a Shared Epigenetic Pathway. Conference. Pain Increases Reward Response to Opioids through a Shared Epigenetic Pathway. Montreal, CA.
- 2014. Pain Facilitates Opioid Reward via an Epigenetic Mechanism. Conference. Symposia for Chinese Neuroscientists Worldwide. Suzhou, CN.
- 2012. Epigenetic Mechanisms for Chronic Pain and Drug Addiction. Conference. International symposium of the society of Chinese bioscientists. Nanjing, CN.
- 2011. Epigenetic Mechanisms of Chronic Pain. Conference. Research Symposium of International Association for the Study of Pain. Shanghai, CN.
- 2010. Delta-Opioid Receptor Trafficking and Functions. Conference. Symposium for Chinese Neuroscientists Worldwide. Nanchang, CN.
- 2007. Central Amygdala: Conjunctive Modulation of Pain and Drug Reward. Conference. International Conference of Neurons and Brain Diseases. Toronto, CA.
- 2003. Synaptic Adaptations and Mechanisms of Analgesic Tolerance to Chronic Opioids. Conference. Annual meeting of International Narcotics Research Conference. Perpignan, FR.
Formal Peers
- 2018. Pain, Emotion and Underlying Brain Circuits and Mechanisms. Invited. Newark, NJ, US.
- 2016. Dissecting the Brain's Pain Circuits for Pain and Opioid Reward. Invited. Lubbock, TX, US.
- 2015. Epigenetic Regulation of Sensory and Affective Pain. Invited. New York, NY, US.
- 2014. Epigenetic Regulation of Sensory and Affective Pain. Invited. Shanghai, CN.
- 2013. How Pain Affects Opioid Reward. Invited. Baltimore, MD, US.
- 2012. Epigenetic mechanisms for chronic pain and opioid reward. Invited. Galveston, TX, US.
- 2011. Understanding the development of chronic pain and opioid addiction. Invited. Shanghai, CN.
- 2010. Functions of Delta-Opioid Receptors in Pain and Addiction. Invited. Shanghai, CN.
- 2007. Opioid Receptor Trafficking. Invited. Houston, TX, US.
- 2007. Central Amygdala in Opioid and Alcohol Addiction and Modulation of Pain. Invited. Emeryville, CA, US.
- 2005. Delta-Opioid Receptor Trafficking and Pain Modulation. Invited. Iowa City, IA, US.
- 2004. Cyclic AMP-Mediated Pain and Opioid Tolerance. Invited. San Francisco, CA, US.
- 2004. Bi-Directional Modulation of Pain by Opioids. Invited. Beijing, CN.
- 2004. Synaptic Mechanisms of Opioid Analgesic Tolerance and Dependence. Invited. Galveston, TX, US.
- 2003. Opioid Modulation of Synaptic Transmission and Pain. Invited. Houston, TX, US.
- 1999. Roles of Opioid Receptors in Opioid Analgesia and Addiction. Invited. Bethesda, MD, US.
- 1997. Opposing Functions of Opioid Receptors. Invited. Minneapolis, MN, US.
Grant & Contract Support
| Date: | 2024 - 2028 |
| Title: | Cortical and Amygdala Circuit Mechanisms for Chronic Pain |
| Funding Source: | DOD |
| Role: | PI |
| ID: | HT94252410686 |
| Date: | 2022 - 2027 |
| Title: | Targeting Tiam1-mediated synaptic plasticity for relief of opioid tolerance, |
| Funding Source: | NIH/NIDA |
| Role: | Co-I |
| ID: | R01-DA056673 |
| Date: | 2019 - 2024 |
| Title: | Dnmt3a as an epigenetic target for chronic pain treatment |
| Funding Source: | NIH/NINDS |
| Role: | PI |
| ID: | R01- NS113256 |
| Date: | 2016 - 2021 |
| Title: | Epigenetic Basis for Pain Vulnerability |
| Funding Source: | NIH/NIDCR |
| Role: | PI |
| ID: | R01DE025943 |
| Date: | 2009 - 2014 |
| Title: | Synaptic mechanisms for interactions of chronic pain and opioid addiction |
| Funding Source: | NIH/NIDA |
| Role: | PI |
| ID: | R01-DA027541 |
| Date: | 2009 - 2011 |
| Title: | Impact of Pain on Sensitivity to Opioid Reward |
| Funding Source: | NIH/NIDA |
| Role: | PI |
| ID: | R21-DA025826 |
| Date: | 2008 - 2013 |
| Title: | Delta-opioid receptor trafficking and Pain inhibition |
| Funding Source: | NIH/NIDA |
| Role: | PI |
| ID: | R01-023069 |
| Date: | 2006 - 2008 |
| Title: | Mechanisms of Cytokine-induced Pain |
| Funding Source: | Institutional Research Grant MDACC |
| Role: | PI |
| Date: | 2001 - 2007 |
| Title: | Opioid Receptors and the Mechanisms of Opioid Tolerance |
| Funding Source: | NIH/NIDA |
| Role: | PI |
| ID: | R01-DA14524 |
Selected Publications
Peer-Reviewed Articles
- Ge J, Cai YQ, Pan ZZ. A Dnmt3a-mediated epigenetic mechanism for chronic pain-induced anxiety behavior in mice. Cells(15):1304, 2026. e-Pub 2026.
- Guanxing Chen, Xin Guan, Hua Wei, You-Qing Cai, Pan ZZ, Hui-Lin Pan, Jiusheng Yan. Transgenic expression of BK channel auxiliary LRRC26 subunit in the forebrain causes locomotor hyperactivity and cognitive defects. eNeuro. e-Pub 2026.
- Cai, Y, Ge, J, Pan, ZZ. The projection from dorsal medial prefrontal cortex to basolateral amygdala promotes behaviors of negative emotion in rats. Frontiers in Neuroscience 18, 2024. e-Pub 2024. PMID: 38327845.
- Karimi, T, Pan, ZZ, Potaman, VN, Alt, EU. Conversion of Unmodified Stem Cells to Pacemaker Cells by Overexpression of Key Developmental Genes. Cells 12(10), 2023. e-Pub 2023. PMID: 37408215.
- Ge, J, Cai, Y, Pan, ZZ. Synaptic plasticity in two cell types of central amygdala for regulation of emotion and pain. Frontiers in Cellular Neuroscience 16, 2022. e-Pub 2022. PMID: 36385947.
- Tao, W, Chen, C, Wang, Y, Zhou, W, Jin, Y, Mao, Y, Wang, H, Wang, L, Xie, W, Zhang, X, Li, J, Li, J, Li, X, Tang, ZQ, Zhou, C, Pan, ZZ, Zhang, Z. MeCP2 mediates transgenerational transmission of chronic pain. Progress in Neurobiology 189, 2020. e-Pub 2020. PMID: 32200043.
- Zhou, C, Wu, Y, Ding, X, Shi, N, Cai, Y, Pan, ZZ. SIRT1 decreases emotional pain vulnerability with associated CaMKIIα deacetylation in central amygdala. Journal of Neuroscience 40(10):2332-2342, 2020. e-Pub 2020. PMID: 32005763.
- Hou, Y, Cai, Y, Pan, ZZ. GluA1 in Central Amygdala Promotes Opioid Use and Reverses Inhibitory Effect of Pain. Neuroscience 426:141-153, 2020. e-Pub 2020. PMID: 31863796.
- Cai, Y, Hou, Y, Pan, ZZ. GluA1 in central amygdala increases pain but inhibits opioid withdrawal-induced aversion. Molecular pain 16, 2020. e-Pub 2020. PMID: 32162577.
- Zhu, X, Zhou, W, Jin, Y, Tang, H, Cao, P, Mao, Y, Xie, W, Zhang, X, Zhao, F, Luo, MH, Wang, H, Li, J, Tao, W, Farzinpour, Z, Wang, L, Li, X, Li, J, Tang, ZQ, Zhou, C, Pan, ZZ, Zhang, Z. A Central Amygdala Input to the Parafascicular Nucleus Controls Comorbid Pain in Depression. Cell Reports 29(12):3847-3858.e5, 2019. e-Pub 2019. PMID: 31851918.
- Lu L, Marisetty A, Liu B, Kamal MM, Gumin J, Veo B, Cai Y, Kassem DH, Weng C, Maynard ME, Hood KN, Fuller GN, Pan ZZ, Cykowski MD, Dash PK, Majumder S. REST overexpression in mice causes deficits in spontaneous locomotion. Sci Rep 8(1):12083, 2018. e-Pub 2018. PMID: 30108242.
- Cai YQ, Wang W, Paulucci-Holthauzen A, Pan ZZ. Brain Circuits Mediating Opposing Effects on Emotion and Pain. J Neurosci 38(28):6340-6349, 2018. e-Pub 2018. PMID: 29941444.
- Wang W, Li C, Cai Y, Pan ZZ. Pain vulnerability and DNA methyltransferase 3a involved in the affective dimension of chronic pain. Mol Pain 13:1744806917726713, 2017. e-Pub 2017. PMID: 28849714.
- Hou YY, Cai YQ, Pan ZZ. Persistent pain maintains morphine-seeking behavior after morphine withdrawal through reduced MeCP2 repression of GluA1 in rat central amygdala. J Neurosci 35(8):3689-700, 2015. e-Pub 2015. PMID: 25716866.
- Cai YQ, Wang W, Hou YY, Pan ZZ. Optogenetic activation of brainstem serotonergic neurons induces persistent pain sensitization. Mol Pain 10:70, 2014. e-Pub 2014. PMID: 25410898.
- Zhang Z, Tao W, Hou YY, Wang W, Lu YG, Pan ZZ. Persistent pain facilitates response to morphine reward by downregulation of central amygdala GABAergic function. Neuropsychopharmacology 39(9):2263-71, 2014. e-Pub 2014. PMID: 24686896.
- Zhang Z, Tao W, Hou YY, Wang W, Kenny PJ, Pan ZZ. MeCP2 repression of G9a in regulation of pain and morphine reward. J Neurosci 34(27):9076-87, 2014. e-Pub 2014. PMID: 24990928.
- Zhang Z, Wang X, Wang W, Lu YG, Pan ZZ. Brain-derived neurotrophic factor-mediated downregulation of brainstem K+-Cl- cotransporter and cell-type-specific GABA impairment for activation of descending pain facilitation. Mol Pharmacol 84(4):511-20, 2013. e-Pub 2013. PMID: 23847084.
- Cai YQ, Wang W, Hou YY, Zhang Z, Xie J, Pan ZZ. Central amygdala GluA1 facilitates associative learning of opioid reward. J Neurosci 33(4):1577-88, 2013. e-Pub 2013. PMID: 23345231.
- Bie B, Wang Y, Cai YQ, Zhang Z, Hou YY, Pan ZZ. Upregulation of nerve growth factor in central amygdala increases sensitivity to opioid reward. Neuropsychopharmacology 37(13):2780-8, 2012. e-Pub 2012. PMID: 22871918.
- Zhang Z, Pan ZZ. Signaling Cascades for Delta-opioid Receptor-mediated Inhibition of GABA Synaptic Transmission and Behavioral Antinociception. Mol Pharmacol 81(3):375-83, 2012. e-Pub 2012. PMID: 22144670.
- Metzele R, Alt C, Bai X, Yan Y, Zhang Z, Pan Z, Coleman M, Vykoukal J, Song YH, Alt E. Human adipose tissue-derived stem cells exhibit proliferation potential and spontaneous rhythmic contraction after fusion with neonatal rat cardiomyocytes. FASEB J 25(3):830-9, 2011. e-Pub 2011. PMID: 21059751.
- Zhang Z, Cai YQ, Zou F, Bie B, Pan ZZ. Epigenetic suppression of GAD65 expression mediates persistent pain. Nat Med 17(11):1448-55, 2011. e-Pub 2011. PMID: 21983856.
- Gopalakrishnan V, Bie B, Sinnappah-Kang ND, Adams H, Fuller GN, Pan ZZ, Majumder S. Myoblast-Derived Neuronal Cells Form Glutamatergic Neurons in the Mouse Cerebellum. Stem Cells 28(10):1839-47, 2010. e-Pub 2010. PMID: 20799335.
- Bie B, Zhang Z, Cai YQ, Zhu W, Zhang Y, Dai J, Lowenstein CJ, Weinman EJ, Pan ZZ. Nerve growth factor-regulated emergence of functional delta-opioid receptors. J Neurosci 30(16):5617-28, 2010. e-Pub 2010. PMID: 20410114.
- Zhang Z, Pan ZZ. Synaptic mechanism for functional synergism between delta- and mu-opioid receptors. J Neurosci 30(13):4735-45, 2010. e-Pub 2010. PMID: 20357124.
- Bie B, Zhu W, Pan ZZ. Ethanol-induced delta-opioid receptor modulation of glutamate synaptic transmission and conditioned place preference in central amygdala. Neuroscience 160(2):348-58, 2009. e-Pub 2009. PMID: 19258026.
- Bie B, Zhu W, Pan ZZ. Rewarding morphine-induced synaptic function of delta-opioid receptors on central glutamate synapses. J Pharmacol Exp Ther 329(1):290-6, 2009. e-Pub 2009. PMID: 19168708.
- Weng HR, Chen JH, Pan ZZ, Nie H. Glial glutamate transporter 1 regulates the spatial and temporal coding of glutamatergic synaptic transmission in spinal lamina II neurons. Neuroscience 149(4):898-907, 2007. e-Pub 2007. PMID: 17935889.
- Bai X, Ma J, Pan Z, Song YH, Freyberg S, Yan Y, Vykoukal D, Alt E. Electrophysiological properties of human adipose tissue-derived stem cells. Am J Physiol Cell Physiol 293(5):C1539-50, 2007. e-Pub 2007. PMID: 17687001.
- Zhu W, Bie B, Pan ZZ. Involvement of non-NMDA glutamate receptors in central amygdala in synaptic actions of ethanol and ethanol-induced reward behavior. J Neurosci 27(2):289-98, 2007. e-Pub 2007. PMID: 17215388.
- Ma JY, Pan ZZ. Contribution of brainstem GABA(A) synaptic transmission to morphine analgesic tolerance. Pain 122(1-2):163-73, 2006. e-Pub 2006. PMID: 16527406.
- Ma JY, Zhang Y, Kalyuzhny AE, Pan ZZ. Emergence of functional &-opioid receptors induced by chronic morphine. Mol. Pharmacol 69:1137-1145, 2006. e-Pub 2006.
- Bie B, Peng Y, Zhang Y, Pan ZZ. cAMP-mediated mechanisms for pain sensitization during opioid withdrawal. J Neurosci 25(15):3824-32, 2005. e-Pub 2005. PMID: 15829634.
- Bie B, Pan ZZ. Increased glutamate synaptic transmission in the nucleus raphe magnus neurons from morphine-tolerant rats. Mol Pain 1(1):7, 2005. e-Pub 2005. PMID: 15813995.
- Zhu W, Pan ZZ. Mu-opioid-mediated inhibition of glutamate synaptic transmission in rat central amygdala neurons. Neuroscience 133(1):97-103, 2005. e-Pub 2005. PMID: 15893634.
- Watanabe Y, Kameoka S, Gopalakrishnan V, Aldape KD, Pan ZZ, Lang FF, Majumder S. Conversion of myoblasts to physiologically active neuronal phenotype. Genes Dev 18(8):889-900, 2004. e-Pub 2004. PMID: 15078815.
- Zhu W, Pan ZZ. Synaptic properties and postsynaptic opioid effects in rat central amygdala neurons. Neuroscience 127(4):871-9, 2004. e-Pub 2004. PMID: 15312899.
- Pan ZZ. An intensified descending pain-facilitating pathway. Drug Discovery Today: Disease Models 1:121-125, 2004. e-Pub 2004.
- Bie B, Pan ZZ. Presynaptic mechanism for anti-analgesic and anti-hyperalgesic actions of kappa-opioid receptors. J Neurosci 23(19):7262-8, 2003. e-Pub 2003. PMID: 12917359.
- Bie B, Fields HL, Williams JT, Pan ZZ. Roles of alpha1- and alpha2-adrenoceptors in the nucleus raphe magnus in opioid analgesia and opioid abstinence-induced hyperalgesia. J Neurosci 23(21):7950-7, 2003. e-Pub 2003. PMID: 12944526.
- Pan ZZ. Kappa-opioid receptor-mediated enhancement of the hyperpolarization-activated current (I(h)) through mobilization of intracellular calcium in rat nucleus raphe magnus. J Physiol 548(Pt 3):765-75, 2003. e-Pub 2003. PMID: 12651920.
- Pan Z, Hirakawa N, Fields HL. A cellular mechanism for the bidirectional pain-modulating actions of orphanin FQ/nociceptin. Neuron 26(2):515-22, 2000. e-Pub 2000. PMID: 10839369.
- Pan ZZ, Tershner SA, Fields HL. Cellular mechanism for anti-analgesic action of agonists of the kappa-opioid receptor. Nature 389(6649):382-5, 1997. e-Pub 1997. PMID: 9311779.
- Pan ZZ, Fields HL. Endogenous opioid-mediated inhibition of putative pain-modulating neurons in rat rostral ventromedial medulla. Neuroscience 74(3):855-62, 1996. e-Pub 1996. PMID: 8884781.
- Pan ZZ, Grudt TJ, Williams JT. Alpha 1-adrenoceptors in rat dorsal raphe neurons: regulation of two potassium conductances. J Physiol 478 Pt 3:437-47, 1994. e-Pub 1994. PMID: 7525947.
- Pan ZZ, Williams JT. Muscarine hyperpolarizes a subpopulation of neurons by activating an M2 muscarinic receptor in rat nucleus raphe magnus in vitro. J Neurosci 14(3 Pt 1):1332-8, 1994. e-Pub 1994. PMID: 8120628.
- Pan ZZ, Tong G, Jahr CE. A false transmitter at excitatory synapses. Neuron 11(1):85-91, 1993. e-Pub 1993. PMID: 8101712.
- Pan ZZ, Wessendorf MW, Williams JT. Modulation by serotonin of the neurons in rat nucleus raphe magnus in vitro. Neuroscience 54(2):421-9, 1993. e-Pub 1993. PMID: 8101640.
- Pan ZZ, Williams JT, Osborne PB. Opioid actions on single nucleus raphe magnus neurons from rat and guinea-pig in vitro. J Physiol 427:519-32, 1990. e-Pub 1990. PMID: 1976803.
- Pan ZZ, Williams JT. Differential actions of cocaine and amphetamine on dorsal raphe neurons in vitro. J Pharmacol Exp Ther 251(1):56-62, 1989. e-Pub 1989. PMID: 2795470.
- Pan ZZ, Colmers WF, Williams JT. 5-HT-mediated synaptic potentials in the dorsal raphe nucleus: interactions with excitatory amino acid and GABA neurotransmission. J Neurophysiol 62(2):481-6, 1989. e-Pub 1989. PMID: 2788717.
- Pan ZZ, Williams JT. GABA- and glutamate-mediated synaptic potentials in rat dorsal raphe neurons in vitro. J Neurophysiol 61(4):719-26, 1989. e-Pub 1989. PMID: 2723717.
- Williams JT, Colmers WF, Pan ZZ. Voltage- and ligand-activated inwardly rectifying currents in dorsal raphe neurons in vitro. J Neurosci 8(9):3499-506, 1988. e-Pub 1988. PMID: 3171686.
- Leger, L, Pan ZZ, Jouvet M, Chiang CY. Anatomical relationships between enkephalin-immunoreactive nerve fibers and serotonin-containing cell bodies in rat nucleus raphe magnus. Chin. J Physiol Sciences 2:143-147, 1986. e-Pub 1986.
- Chiang CY, Pan ZZ. Differential responses of serotonergic and non-serotonergic neurons in nucleus raphe magnus to systemic morphine in rats. Brain Res 337(1):146-50, 1985. e-Pub 1985. PMID: 4005602.
Invited Articles
- Pan ZZ. A Life Switch in Pain. Pain(153):738-739, 2012. e-Pub 2012. PMID: 22342072.
Review Articles
- Pan ZZ. Transcriptional control of Gad2. Transcription 3(2):68-72, 2012. e-Pub 2012. PMID: 22414751.
- Bie B, Pan ZZ. Trafficking of central opioid receptors and descending pain inhibition. Mol Pain 3:37, 2007. e-Pub 2007. PMID: 18053223.
- Pan ZZ. mu-Opposing actions of the kappa-opioid receptor. Trends Pharmacol Sci 19(3):94-8, 1998. e-Pub 1998. PMID: 9584625.
- Pan ZZ, Jiang ZY. [Anatomic and neurophysiologic studies on nucleus raphe magnus]. Sheng Li Ke Xue Jin Zhan 17(3):199-205, 1986. e-Pub 1986. PMID: 3541177.
Other Articles
- Lu, L, Marisetty, AL, Liu, B, Kamal, MM, Gumin, J, Veo, BL, Cai, Y, Kassem, DH, Weng, C, Maynard, ME, Hood, KN, Fuller, GN, Pan, ZZ, Cykowski, MD, Dash, PK, Majumder, S Author Correction: REST overexpression in mice causes deficits in spontaneous locomotion. Scientific reports 12(1), 2022. PMID: 36526687.
Abstracts
- Li CY, Zhou CH, Cai YQ, Pan ZZ. Pain vulnerability is inherent in affective dimension of chronic pain, 2017. e-Pub 2017.
- Cai YQ, Wang W, Pan ZZ. Exploring the epigenetic mechanisms for individual pain vulnerability(13):1-40, 2017. e-Pub 2017.
- Cai YQ, Pan ZZ. Optogenetic stimulation of the excitatory paracrachial projections to central maygdala induces anxiety- and depression-like behaviors in rats, 2016. e-Pub 2016.
- Hou YY, Cai YQ, Pan ZZ. AMPA receptors in central amygdala mediate pain-induced suppression of opioid reward, 2012. e-Pub 2012.
- Zhang Z, Hou YY, Zia Y, Wang W, Pan ZZ. Down-regulation of GABAergic function in the CeA mediates morphine reward, 2012. e-Pub 2012.
- Cai YQ, Hou YY, Pan ZZ. GluR1 of AMPA receptors in rostral ventromedial medulla mediates descending pain inhibition in rats with persistent pain, 2012. e-Pub 2012.
- Zhang Z, Pan ZZ. Cell-type specific downregulation of KCC2 reduces GABAergic transmission in brainstem neurons after persistent inflammatory pain, 2011. e-Pub 2011.
- Cai YQ, Hou YY, Pan ZZ. Upregulation of central amygdala AMPA GluR1 subunits facilitates behavior of opioid reward, 2011. e-Pub 2011.
- Bie B, Zhang Z, Cai YQ, Reyes F, Pan ZZ. Delta-Opioid Receptor Trafficking and Functions, 2010. e-Pub 2010.
- Zhang Z, Pan ZZ. Signaling cascade for delta-opioid receptor-induced inhibition of GABA synaptic transmission, 2010. e-Pub 2010.
- Zhang, Z, Pan ZZ. Presynaptic mechanisms for synergistic inhibition of GABA synaptic transmission by delta- and mu-opioid receptors, 2009. e-Pub 2009.
- Zhu W, Bie B, Pan, ZZ. Central amygdala: conjunctive modulation of pain and drug reward, 2007. e-Pub 2007.
- Bie B, Pan ZZ. Alcohol induces trafficking of delta-opioid receptors in central amygdala, 2007. e-Pub 2007.
- Chen JH, Pan ZZ, Weng HR. Excitatory postsynaptic activities in substantia gelatinosa neurons are regulated by glial glutamate transporters, 2006. e-Pub 2006.
- Zhu, W, Pan ZZ. Chronic ethanol enhances glutamate synaptic transmission and ethanol inhibition in neurons of rat central amygdala, 2005. e-Pub 2005.
- Ma, JY, Pan ZZ. Up-regulation of delta-opioid receptor function in the nucleus raphe magnus of morphine-tolerant rats, 2005. e-Pub 2005.
- Ma, JY, Pan ZZ. Increased GABA synaptic transmission through upregulation of the cAMP pathway in morphine-dependent rats, 2004. e-Pub 2004.
- Zhu, W, Pan ZZ. Inhibition of non-NMDA glutamatergic synaptic transmission by ethanol in rat central nucleus of the amygdala, 2004. e-Pub 2004.
- Bie, B, Pan ZZ. Cyclic AMP-dependent pathway modulates glutamatergic synaptic transmission during morphine withdrawal, 2004. e-Pub 2004.
- Bie, B, Pan ZZ. Chronic morphine treatment alters glutamatergic synaptic transmission in rat nucleus raphe magnus, 2003. e-Pub 2003.
- Zhu, W, Pan ZZ. Presynaptic inhibition of glutamate synaptic transmission by mu-opioid receptors in rat central nucleus of the amygdala, 2003. e-Pub 2003.
- Ma, JY, Bie B, Pan ZZ. Synaptic adaptations and mechanisms of analgesic tolerance to chronic opioids, 2003. e-Pub 2003.
- Bie, B, Pan ZZ. Anti-analgesic actions of kappa receptors by a presynaptic mechanism, 2002. e-Pub 2002.
Book Chapters
- Pan, ZZ, Zhou, C, Wu, Y, Zhang, Z, Cai, Y. Pain-Induced Chromatin Modifications. In: Epigenetics of Chronic Pain. Elsevier, 111-124, 2019.
- Pan ZZ. Opioid Receptors. In: Molecular Pain. Higher Education Press, 2007.
- Pan ZZ. Mechanisms of Opioid Tolerance. In: Molecular Pain. Higher Education Press, 2007.
- Pan ZZ. Opioid Tolerance in Adult and Neonatal Rats. In: Opioid Research: Methods and Protocols / Methods in Molecular Medicine. Humana Press, 223-232, 2003.
Books (edited and written)
- Pan ZZ. Opioid Research: Methods and Protocols. Humana Press, 2003.
Patient Reviews
CV information above last modified September 15, 2026