Sharon Y.R. Dent, Ph.D.

Peer-Reviewed Articles

1. Perez CJ, Mecklenburg L, Fernandez A, Cantero M, de Souza TA, Lin K, Dent SYR, Montoliu L, Awgulewitsch A, Benavides F. Naked (N) mutant mice carry a nonsense mutation in the homeobox of Hoxc13. Exp Dermatol 31(3):330-340, 2022. e-Pub 2021. PMID: 34657330.
2. Kuang X, McAndrew MJ, Mustachio LM, Chen YC, Atanassov BS, Lin K, Lu Y, Shen J, Salinger A, Macatee T, Dent SYR, Koutelou E. Usp22 Overexpression Leads to Aberrant Signal Transduction of Cancer-Related Pathways but Is Not Sufficient to Drive Tumor Formation in Mice. Cancers (Basel) 13(17), 2021. e-Pub 2021. PMID: 34503086.
3. Farria AT, Plummer JB, Salinger AP, Shen J, Lin K, Lu Y, McBride KM, Koutelou E, Dent SYR. Transcriptional Activation of MYC-Induced Genes by GCN5 Promotes B-cell Lymphomagenesis. Cancer Res 80(24):5543-5553, 2020. e-Pub 2020. PMID: 33168647.
4. Farria AT, Mustachio LM, Akdemir ZHC, Dent SYR. GCN5 HAT inhibition reduces human Burkitt lymphoma cell survival through reduction of MYC target gene expression and impeding BCR signaling pathways. Oncotarget 10(56):5847-5858, 2019. PMID: 31645904.
5. Mustachio LM, Roszik J, Farria AT, Guerra K, Dent SY. Repression of GCN5 expression or activity attenuates c-MYC expression in non-small cell lung cancer. Am J Cancer Res 9(8):1830-1845, 2019. PMID: 31497362.
6. Liu Y, Bao C, Wang L, Han R, Beier UH, Akimova T, Cole PA, Dent SYR, Hancock WW. Complementary Roles of GCN5 and PCAF in Foxp3+ T-Regulatory Cells. Cancers (Basel) 11(4), 2019. e-Pub 2019. PMID: 31003455.
7. Koutelou E, Wang L, Schibler AC, Chao HP, Kuang X, Lin K, Lu Y, Shen J, Jeter CR, Salinger A, Wilson M, Chen YC, Atanassov BS, Tang DG, Dent SYR. USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta. Development 146(4), 2019. e-Pub 2019. PMID: 30718289.
8. Lambies G, Miceli M, Martínez-Guillamon C, Olivera-Salguero R, Peña R, Frías CP, Calderón I, Atanassov BS, Dent SYR, Arribas J, García de Herreros A, Díaz VM. TGFβ-Activated USP27X Deubiquitinase Regulates Cell Migration and Chemoresistance via Stabilization of Snail1. Cancer Res 79(1):33-46, 2019. e-Pub 2018. PMID: 30341066.
9. Bao J, Perez CJ, Kim J, Zhang H, Murphy CJ, Hamidi T, Jaubert J, Platt CD, Chou J, Deng M, Zhou MH, Huang Y, Gaitán-Peñas H, Guénet JL, Lin K, Lu Y, Chen T, Bedford MT, Dent SY, Richburg JH, Estévez R, Pan HL, Geha RS, Shi Q, Benavides F. Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice. JCI Insight 3(16), 2018. e-Pub 2018. PMID: 30135305.
10. Appikonda S, Thakkar KN, Shah PK, Dent SYR, Andersen JN, Barton MC. Cross-talk between chromatin acetylation and SUMOylation of tripartite motif-containing protein 24 (TRIM24) impacts cell adhesion. J Biol Chem 293(19):7476-7485, 2018. e-Pub 2018. PMID: 29523690.
11. Franco HL, Nagari A, Malladi VS, Li W, Xi Y, Richardson D, Allton KL, Tanaka K, Li J, Murakami S, Keyomarsi K, Bedford MT, Shi X, Li W, Barton MC, Dent SYR, Kraus WL. Enhancer transcription reveals subtype-specific gene expression programs controlling breast cancer pathogenesis. Genome Res 28(2):159-170, 2018. e-Pub 2017. PMID: 29273624.
12. Xi Y, Shi J, Li W, Tanaka K, Allton KL, Richardson D, Li J, Franco HL, Nagari A, Malladi VS, Coletta LD, Simper MS, Keyomarsi K, Shen J, Bedford MT, Shi X, Barton MC, Kraus WL, Li W, Dent SYR. Histone modification profiling in breast cancer cell lines highlights commonalities and differences among subtypes. BMC Genomics 19(1):150, 2018. e-Pub 2018. PMID: 29458327.
13. Wang L, Koutelou E, Hirsch C, McCarthy R, Schibler A, Lin K, Lu Y, Jeter C, Shen J, Barton MC, Dent SYR. GCN5 Regulates FGF Signaling and Activates Selective MYC Target Genes during Early Embryoid Body Differentiation. Stem Cell Reports 10(1):287-299, 2018. e-Pub 2017. PMID: 29249668.
14. Platt CD, Chou J, Houlihan P, Badran YR, Kumar L, Bainter W, Poliani PL, Perez CJ, Dent SYR, Clapham DE, Benavides F, Geha RS. LRRC8A-dependent volume regulated anion channel activity is dispensable for T cell development and function. J Allergy Clin Immunol 140(6):1651-1659.e1, 2017. e-Pub 2017. PMID: 28192143.
15. Mi W, Guan H, Lyu J, Zhao D, Xi Y, Jiang S, Andrews FH, Wang X, Gagea M, Wen H, Tora L, Dent SYR, Kutateladze TG, Li W, Li H, Shi X. YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer. Nat Commun 8(1):1088, 2017. e-Pub 2017. PMID: 29057918.
16. Wang Y, Yun C, Gao B, Xu Y, Zhang Y, Wang Y, Kong Q, Zhao F, Wang CR, Dent SYR, Wang J, Xu X, Li HB, Fang D. The Lysine Acetyltransferase GCN5 Is Required for iNKT Cell Development through EGR2 Acetylation. Cell Rep 20(3):600-612, 2017. PMID: 28723564.
17. Butler JS, Qiu YH, Zhang N, Yoo SY, Coombes KR, Dent SY, Kornblau SM. Low expression of ASH2L protein correlates with a favorable outcome in acute myeloid leukemia. Leuk Lymphoma 58(5):1207-1218, 2017. e-Pub 2016. PMID: 28185526.
18. Gao B, Kong Q, Zhang Y, Yun C, Dent SYR, Song J, Zhang DD, Wang Y, Li X, Fang D. The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation. J Immunol 198(10):3927-3938, 2017. e-Pub 2017. PMID: 28424240.
19. Wilde JJ, Siegenthaler JA, Dent SY, Niswander LA. Diencephalic Size is Restricted by a Novel Interplay Between GCN5 Acetyltransferase Activity and Retinoic Acid Signaling. J Neurosci 37(10):2565-2579, 2017. e-Pub 2017. PMID: 28154153.
20. Li W, Atanassov BS, Lan X, Mohan RD, Swanson SK, Farria AT, Florens L, Washburn MP, Workman JL, Dent SY. Cytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA Deubiquitinase Module. Mol Cell Biol 36(22):2855-2866, 2016. e-Pub 2016. PMID: 27601583.
21. Lan X, Atanassov BS, Li W, Zhang Y, Florens L, Mohan RD, Galardy PJ, Washburn MP, Workman JL, Dent SY. USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B. Cell Rep 17(9):2382-2393, 2016. PMID: 27880911.
22. Atanassov BS, Mohan RD, Lan X, Kuang X, Lu Y, Lin K, McIvor E, Li W, Zhang Y, Florens L, Byrum SD, Mackintosh SG, Calhoun-Davis T, Koutelou E, Wang L, Tang DG, Tackett AJ, Washburn MP, Workman JL, Dent SY. ATXN7L3 and ENY2 coordinate activity of multiple H2B deubiquitinases important for cellular proliferation and tumor growth. Mol Cell 62(4):558-71, 2016. e-Pub 2016. PMID: 27132940.
23. Schibler A, Koutelou E, Tomida J, Wilson-Pham M, Wang L, Lu Y, Cabrera AP, Chosed RJ, Li W, Li B, Shi X, Wood RD, Dent SY. Histone H3K4 methylation regulates deactivation of the spindle assembly checkpoint through direct binding of Mad2. Genes Dev 30(10):1187-97, 2016. e-Pub 2016. PMID: 27198228.
24. Perez CJ, Mecklenburg L, Jaubert J, Martinez-Santamaria L, Iritani BM, Espejo A, Napoli E, Song G, del Río M, DiGiovanni J, Giulivi C, Bedford MT, Dent SY, Wood RD, Kusewitt DF, Guénet JL, Conti CJ, Benavides F. Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene. J Invest Dermatol 135(12):3133-43, 2015. e-Pub 2015. PMID: 26288350.
25. Li Y, Polak U, Bhalla AD, Rozwadowska N, Butler JS, Lynch DR, Dent SY, Napierala M. Excision of expanded GAA repeats alleviates the molecular phenotype of Friedreich's ataxia. Mol Ther 23(6):1055-65, 2015. e-Pub 2015. PMID: 25758173.
26. Hirsch CL, Coban Akdemir Z, Wang L, Jayakumaran G, Trcka D, Weiss A, Hernandez JJ, Pan Q, Han H, Xu X, Xia Z, Salinger AP, Wilson M, Vizeacoumar F, Datti A, Li W, Cooney AJ, Barton MC, Blencowe BJ, Wrana JL, Dent SY. Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming. Genes Dev 29(8):803-16, 4/2015. PMCID: PMC4403257. Corrigendum: Genes Dev 29(12):1341. PMCID: PMC4495403, 2015.
27. Lan X, Koutelou E, Schibler AC, Chen YC, Grant PA, Dent SY. PolyQ expansions in ATXN7 affect solubility but not activity of the SAGA deubiquitinating module. Mol Cell Biol 35(10):1777-87, 2015. e-Pub 2015. PMID: 25755283.
28. Jin Q, Zhuang L, Lai B, Wang C, Li W, Dolan B, Lu Y, Wang Z, Zhao K, Peng W, Dent SY, Ge K. Gcn5 and PCAF negatively regulate interferon-β production through HAT-independent inhibition of TBK1. EMBO Rep 15(11):1192-201, 2014. e-Pub 2014. PMID: 25269644.
29. Jin Q, Wang C, Kuang X, Feng X, Sartorelli V, Ying H, Ge K, Dent SY. Gcn5 and PCAF regulate PPARγ and Prdm16 expression to facilitate brown adipogenesis. Mol Cell Biol 34(19):3746-53, 2014. e-Pub 2014. PMID: 25071153.
30. Li Y, Wen H, Xi Y, Tanaka K, Wang H, Peng D, Ren Y, Jin Q, Dent SY, Li W, Li H, Shi X. AF9 YEATS Domain Links Histone Acetylation to DOT1L-Mediated H3K79 Methylation. Cell 159(3):558-71, 2014. PMID: 25417107.
31. Stilling RM, Rönicke R, Benito E, Urbanke H, Capece V, Burkhardt S, Bahari-Javan S, Barth J, Sananbenesi F, Schütz AL, Dyczkowski J, Martinez-Hernandez A, Kerimoglu C, Dent SY, Bonn S, Reymann KG, Fischer A. K-Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation. EMBO J 33(17):1912-27, 2014. e-Pub 2014. PMID: 25024434.
32. Ravnskjaer K, Hogan MF, Lackey D, Tora L, Dent SY, Olefsky J, Montminy M. Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects. J Clin Invest 123(10):4318-28, 2013. e-Pub 2013. PMID: 24051374.
33. Polak U, McIvor E, Dent SY, Wells RD, Napierala M. Expanded complexity of unstable repeat diseases. Biofactors 39(2):164-75, 2013. e-Pub 2012. PMID: 23233240.
34. Chen K, Wilson MA, Hirsch C, Watson A, Liang S, Lu Y, Li W, Dent SY. Stabilization of the promoter nucleosomes in nucleosome free regions by the yeast Cyc8-Tup1 corepressor. Genome Res 23(2):312-22, 2013. e-Pub 2012. PMID: 23124522.
35. McCullough SD, Xu X, Dent SY, Bekiranov S, Roeder RG, Grant PA. Reelin is a target of polyglutamine expanded ataxin-7 in human SCA7 astrocytes. Proc Natl Acad Sci U S A 109(52):21319-24, 2012. e-Pub 2012. PMID: 23236151.
36. Chen YC, Gatchel JR, Lewis RW, Mao CA, Grant PA, Zoghbi HY, Dent SY. Gcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model. Hum Mol Genet 21(2):394-405, 2012. e-Pub 2011. PMID: 22002997.
37. Polak U, Hirsch C, Ku S, Gottesfeld J, Dent SY, Napierala M. Selecting and isolating colonies of human induced pluripotent stem cells reprogrammed from adult fibroblasts. J Vis Exp(60), 2012. e-Pub 2012. PMID: 22370855.
38. Martínez-Cerdeño V, Lemen JM, Chan V, Wey A, Lin W, Dent SR, Knoepfler PS. N-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cells. PLoS One 7(6):e39456, 2012. e-Pub 2012. PMID: 22745758.
39. Kim E, Napierala M, Dent SY. Hyperexpansion of GAA repeats affects post-initiation steps of FXN transcription in Friedreich's ataxia. Nucleic Acids Res 39(19):1-12, 2011. e-Pub 2011. PMID: 21745819.
40. Latham JA, Chosed RJ, Wang S, Dent SY. Chromatin signaling to kinetochores: Trans-regulation of Dam1 methylation by histone H2B ubiquitination. Cell 146(5):709-19, 2011. PMID: 21884933.
41. Atanassov BS, Dent SY. USP22 regulates cell proliferation by deubiquitinating the transcriptional regulator FBP1. EMBO Rep 12(9):924-30, 2011. e-Pub 2011. PMID: 21779003.
42. Wilson MA, Koutelou E, Hirsch C, Akdemir K, Schibler A, Barton MC, Dent SY. Ubp8 and SAGA regulate Snf1 AMP kinase activity. Mol Cell Biol 31(15):3126-3135, 2011. e-Pub 2011. PMID: 21628526.
43. Xu CR, Cole PA, Meyers DJ, Kormish J, Dent S, Zaret KS. Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas. Science 332(6032):963-966, 2011. PMID: 21596989.
44. Butler JS, Zurita-Lopez CI, Clarke SG, Bedford MT, Dent SY. Protein arginine methyltransferase 1 (PRMT1) methylates ASH2L, a shared component of mammalian histone H3K4 methyltransferase complexes. J Biol Chem 286(14):12234-44, 2011. e-Pub 2011. PMID: 21285357.
45. Jin Q, Yu LR, Wang L, Zhang Z, Kasper LH, Lee JE, Wang C, Brindle PK, Dent SY, Ge K. Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation. EMBO J 30(2):249-62, 2011. e-Pub 2010. PMID: 21131905.
46. Sinha KM, Yasuda H, Coombes MM, Dent SY, de Crombrugghe B. Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase. EMBO J 29(1):68-79, 2010. e-Pub 2009. PMID: 19927124.
47. Lin Y, Dent SY, Wilson JH, Wells RD, Napierala M. R loops stimulate genetic instability of CTG.CAG repeats. Proc Natl Acad Sci U S A 107(2):692-7, 2010. e-Pub 2009. PMID: 20080737.
48. Atanassov BS, Evrard YA, Multani AS, Zhang Z, Tora L, Devys D, Chang S, Dent SY. Gcn5 and SAGA Regulate Shelterin Protein Turnover and Telomere Maintenance. Mol Cell 35(3):352-364, 2009. PMID: 19683498.
49. Loyola A, Tagami H, Bonaldi T, Roche D, Quivy JP, Imhof A, Nakatani Y, Dent SY, Almouzni G. The HP1alpha-CAF1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin. EMBO Rep 10(7):769-75, 2009. e-Pub 2009. PMID: 19498464.
50. Lin W, Zhang Z, Srajer G, Chen YC, Huang M, Phan HM, Dent SY. Proper expression of the Gcn5 histone acetyltransferase is required for neural tube closure in mouse embryos. Dev Dyn 237(4):928-940, 2008. PMID: 18330926.
51. Soragni E, Herman D, Dent SYR, Gottesfeld JM, Wells RD, and Napierala M.. Long intronic GAA-TTC repeats induce epigenetic changes and reporter gene silencing in a molecular model of Friedreich ataxia. Nucleic Acids Research 36:6056-6065, 2008.
52. Allis CD, Berger SL, Cote J, Dent S, Jenuwien T, Kouzarides T, Pillus L, Reinberg D, Shi Y, Shiekhattar R, Shilatifard A, Workman J, Zhang Y. New Nomenclature for Chromatin-Modifying Enzymes. Cell 131(4):633-636, 2007. e-Pub 2007. PMID: 18022353.
53. Zhang X, Yuan Z, Zhang Y, Yong S, Salas-Burgos A, Koomen J, Olashaw N, Parsons JT, Yang XJ, Dent SR, Yao TP, Lane WS, Seto E. HDAC6 Modulates Cell Motility by Altering the Acetylation Level of Cortactin. Mol Cell 27(2):197-213, 2007. e-Pub 2007. PMID: 17643370.
54. Lin W, Srajer G, Evrard YA, Phan HM, Furuta Y, Dent SY. Developmental potential of Gcn5(-/-) embryonic stem cells in vivo and in vitro. Dev Dyn 236(6):1547-1557, 2007. PMID: 17440986.
55. Tripic T, Edmondson DG, Davie JK, Strahl BD, Dent SY. The Set2 methyltransferase associates with Ssn6 yet Tup1-Ssn6 repression is independent of histone methylation. Biochem Biophys Res Commun 339(3):905-14, 2006. e-Pub 2005. PMID: 16329992.
56. Zhang K, Lin W, Latham JA, Riefler GM, Schumacher JM, Chan C, Tatchell K, Hawke DH, Kobayashi R, Dent SY. The Set1 methyltransferase opposes Ipl1 aurora kinase functions in chromosome segregation. Cell 122(5):723-34, 2005. PMID: 16143104.
57. Phan HM, Xu AW, Coco C, Srajer G, Wyszomierski S, Evrard YA, Eckner R, Dent SY. GCN5 and p300 share essential functions during early embryogenesis. Dev Dyn 233(4):1337-47, 2005. PMID: 15937931.
58. Coombes MM, Briggs KL, Bone JR, Clayman GL, El-Naggar AK, Dent SY. Resetting the histone code at CDKN2A in HNSCC by inhibition of DNA methylation. Oncogene 22(55):8902-11, 2003. PMID: 14654786.
59. Davie JK, Edmondson DG, Coco CB, Dent SY. Tup1-Ssn6 interacts with multiple class I histone deacetylases in vivo. J Biol Chem 278(50):50158-62, 2003. e-Pub 2003. PMID: 14525981.
60. Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E. c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation. J Biol Chem 278(22):20405-12, 2003. e-Pub 2003. PMID: 12660246.
61. Mukai Y, Davie JK, Dent SY. Physical and functional interaction of the yeast corepressor Tup1 with mRNA 5'-triphosphatase. J Biol Chem 278(21):18895-901, 2003. e-Pub 2003. PMID: 12637515.
62. Edmondson DG, Davie JK, Zhou J, Mirnikjoo B, Tatchell K, Dent SY. Site-specific loss of acetylation upon phosphorylation of histone H3. J Biol Chem 277(33):29496-502, 2002. e-Pub 2002. PMID: 12039950.
63. Davie JK, Trumbly RJ, Dent SY. Histone-dependent association of Tup1-Ssn6 with repressed genes in vivo. Mol Cell Biol 22(3):693-703, 2002. PMID: 11784848.
64. Briggs SD, Bryk M, Strahl BD, Cheung WL, Davie JK, Dent SY, Winston F, Allis CD. Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae. Genes Dev 15:3286-95, 2001. PMID: 11751634.
65. Wu, W-S, Vallian, S, Seto, E, Yang, W-M, Edmondson, DG, Roth, , SY, Chang K-S. The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases. Mol. Cell. Biol 21:2259-2268, 2001.
66. Roth SY, Denu JM, Allis CD. Histone acetyltransferases. Annu Rev Biochem 70:81-120, 2001. PMID: 11395403.
67. Bone JR, Roth SY. Recruitment of the yeast Tup1p-Ssn6p repressor is associated with localized decreases in histone acetylation. J Biol Chem 276:1808-13, 2001. PMID: 11056171.
68. Watson AD, Edmondson DG, Bone JR, Mukai Y, Yu Y, Du W, Stillman DJ, Roth SY. Ssn6-Tup1 interacts with class I histone deacetylases required for repression. Genes Dev 14:2737-44, 2000. PMID: 11069890.
69. Xu W, Edmondson DG, Evrard YA, Wakamiya M, Behringer RR, Roth SY. Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development. Nat Genet 26:229-32, 2000. PMID: 11017084.
70. Mukai Y, Matsuo E, Roth SY, Harashima S. Conservation of histone binding and transcriptional repressor functions in a Schizosaccharomyces pombe Tup1p homolog. Mol Cell Biol 19:8461-8, 1999. PMID: 10567571.
71. Xu W, Edmondson DG, Roth SY. Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates. Mol Cell Biol 18:5659-69, 1998. PMID: 9742083.
72. Edmondson DG, Roth SY. Interactions of transcriptional regulators with histones. Methods 15:355-64, 1998. PMID: 9740723.
73. Zhang W, Bone JR, Edmondson DG, Turner BM, Roth SY. Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gcn5p acetyltransferase. Embo J 17:3155-67, 1998. PMID: 9606197.
74. Edmondson DG, Zhang W, Watson A, Xu W, Bone JR, Yu Y, Stillman D, Roth SY. In vivo functions of histone acetylation/deacetylation in Tup1p repression and Gcn5p activation. Cold Spring Harb Symp Quant Biol 63:459-68, 1998. PMID: 10384310.
75. Huang L, Zhang W, Roth SY. Amino termini of histones H3 and H4 are required for a1-alpha2 repression in yeast. Mol Cell Biol 17:6555-62, 1997. PMID: 9343419.
76. Macatee T, Jiang YW, Stillman DJ, Roth SY. Global alterations in chromatin accessibility associated with loss of SIN4 function. Nucleic Acids Res 25:1240-7, 1997. PMID: 9092635.
77. Kuo MH, Brownell JE, Sobel RE, Ranalli TA, Cook RG, Edmondson DG, Roth SY, Allis CD. Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines. Nature 383:269-72, 1996. PMID: 8805705.
78. Edmondson DG, Smith MM, Roth SY. Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4. Genes Dev 10:1247-59, 1996. PMID: 8675011.
79. Brownell JE, Zhou J, Ranalli T, Kobayashi R, Edmondson DG, Roth SY, Allis CD. Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation. Cell 84:843-51, 1996. PMID: 8601308.
80. Cooper JP, Roth SY, Simpson RT. The global transcriptional regulators, SSN6 and TUP1, play distinct roles in the establishment of a repressive chromatin structure. Genes Dev 8:1400-10, 1994. PMID: 7926740.
81. Murphy MR, Shimizu M, Roth SY, Dranginis AM, Simpson RT. DNA-protein interactions at the S.cerevisiae alpha 2 operator in vivo. Nucleic Acids Res 21:3295-300, 1993. PMID: 8341604.
82. Simpson RT, Roth SY, Morse RH, Patterton HG, Cooper JP, Murphy M, Kladde MP, Shimizu M. Nucleosome positioning and transcription. Cold Spring Harb Symp Quant Biol 58:237-45, 1993. PMID: 7956034.
83. Morse RH, Roth SY, Simpson RT. A transcriptionally active tRNA gene interferes with nucleosome positioning in vivo. Mol Cell Biol 12:4015-25, 1992. PMID: 1508199.
84. Roth SY, Shimizu M, Johnson L, Grunstein M, Simpson RT. Stable nucleosome positioning and complete repression by the yeast alpha 2 repressor are disrupted by amino-terminal mutations in histone H4. Genes Dev 6:411-25, 1992. PMID: 1547940.
85. Shimizu M, Roth SY, Szent-Gyorgyi C, Simpson RT. Nucleosomes are positioned with base pair precision adjacent to the alpha 2 operator in Saccharomyces cerevisiae. Embo J 10:3033-41, 1991. PMID: 1915278.
86. Roth SY, Collini MP, Draetta G, Beach D, Allis CD. A cdc2-like kinase phosphorylates histone H1 in the amitotic macronucleus of Tetrahymena. Embo J 10:2069-75, 1991. PMID: 2065655.
87. Roth, SY, Simpson, RT. Yeast minichromosomes. Meth. Cell Biol 35:289-314, 1991.
88. Roth SY, Dean A, Simpson RT. Yeast alpha 2 repressor positions nucleosomes in TRP1/ARS1 chromatin. Mol Cell Biol 10:2247-60, 1990. PMID: 2183026.
89. Roth SY, Schulman IG, Richman R, Cook RG, Allis CD. Characterization of phosphorylation sites in histone H1 in the amitotic macronucleus of Tetrahymena during different physiological states. J Cell Biol 107:2473-82, 1988. PMID: 3204116.
90. Roth SY, Schulman IG, Cook RG, Allis CD. The complete amino acid sequence of an HMG-like protein isolated from the macronucleus of Tetrahymena. Nucleic Acids Res 15:8112, 1987. PMID: 3671074.
91. Nickel BE, Roth SY, Cook RG, Allis CD, Davie JR. Changes in the histone H2A variant H2A.Z and polyubiquitinated histone species in developing trout testis. Biochemistry 26:4417-21, 1987. PMID: 2822092.
92. Yoder SS, Berget SM. Role of adenovirus type 2 early region 4 in the early-to-late switch during productive infection. J Virol 60:779-81, 1986. PMID: 3773056.
93. Yoder SS, Berget SM. Posttranscriptional control of DHFR gene expression during adenovirus 2 infection. J Virol 54:72-7, 1985. PMID: 2983122.
94. Yoder SS, Robberson BL, Leys EJ, Hook AG, Al-Ubaidi M, Yeung CY, Kellems RE, Berget SM. Control of cellular gene expression during adenovirus infection: induction and shut-off of dihydrofolate reductase gene expression by adenovirus type 2. Mol Cell Biol 3:819-28, 1983. PMID: 6865943.
95. Jacobson MK, Barton RA, Yoder SS, Sigh S, Lyle RE. Mutagenicity of the non-carcinogenic dibenzylnitrosamine and an alpha-acetoxy derivative. Cancer Lett 6:83-7, 1979. PMID: 35280.

Invited Articles

1. Dent SY. Grand challenge in chromatin epigenomics: everything, everywhere, all at once. Front. Epigenet. Epgenom Volume 1-2023, 2023.
2. Koutelou E, Dent SYR. Navigating EMT with COMPASS and PRC2. Nat Cell Biol 24(4):412-414, 2022. PMID: 35411082.
3. Chen YC, Koutelou E, Dent SYR. Now Open: Evolving Insights to the Roles of Lysine Acetylation in Chromatin Organization and Function. Mol Cell 82(4):716-727, 2022. e-Pub 2022. PMID: 35016034.
4. Chen YC, Dent SYR. Conservation and diversity of the eukaryotic SAGA coactivator complex across kingdoms. Epigenetics Chromatin 14(1):26, 2021. e-Pub 2021. PMID: 34112237.
5. Koutelou E, Farria AT, Dent SYR. Complex functions of Gcn5 and Pcaf in development and disease. Biochim Biophys Acta Gene Regul Mech 1864(2):194609, 2021. e-Pub 2020. PMID: 32730897.
6. Mustachio LM, Roszik J, Farria A, Dent SYR. Targeting the SAGA and ATAC Transcriptional Coactivator Complexes in MYC-Driven Cancers. Cancer Res 80(10):1905-1911, 2020. e-Pub 2020. PMID: 32094302.
7. Hirsch CL, Wrana JL, Dent SYR. KATapulting toward Pluripotency and Cancer. J Mol Biol S0022-2836(16):30415-6, 2017. e-Pub 2016. PMID: 27720985.
8. Farria A, Li W, and Dent, SYR. KATs in Cancer: Functions and Therapies. Oncogene 34(38):4901-13, 2015. e-Pub 2015.
9. Wang L, Dent SY. Functions of SAGA in development and disease. Epigenomics 6(3):329-39, 2014. PMID: 25111486.
10. Chen T, Dent SY. Chromatin modifiers and remodellers: regulators of cellular differentiation. Nat Rev Genet 15(2):93-106, 2014. e-Pub 2013. PMID: 24366184.
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