Stephanie S. Watowich, Ph.D.
Department of Immunology, Division of Discovery Science
About Dr. Watowich
Dr. Stephanie Watowich is Professor and Deputy Chair in the Department of Immunology and the Director of the Center for Inflammation and Cancer at MD Anderson Cancer Center. Through work in her lab she seeks to understand how innate immune cells are generated and their role in regulating the immune response to cancer or extracellular pathogens. She received her PhD from Northwestern University and postdoctoral training in the lab of Harvey Lodish at the Whitehead Institute, giving her a broad scientific background in cellular and molecular biology as well as expertise in blood and immune cell development. She has conducted studies on transcriptional regulation, cytokine receptor structure/function, cytokine signaling and hematopoiesis for over two decades. Her lab has defined roles for STATs in erythropoiesis, granulopoiesis, and dendritic cell (DC) generation, including in-depth studies of STAT function in vivo and identification of STAT target genes that regulate blood cell growth and differentiation. The lab is currently focused on determining the potential role of STATs in the regulation of hematopoietic stem cells and myeloid/DC lineage differentiation. Dr. Watowich has received numerous awards for her efforts in mentoring and teaching including the John P. McGovern Outstanding Teacher Award and the William Randolph Hearst Foundation Faculty Achievement Award in Education. She has directed numerous cross-disciplinary research teams funded by grants and by the pharmaceutical companies and has an extensive publication record spanning three decades.
Present Title & Affiliation
Primary Appointment
Professor, Department of Immunology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
Hematopoiesis, dendritic cells, innate immunity, STAT transcription factors. Our long term interest centers on the molecular regulation of innate immunity by cytokines and transcription factors, with a specific focus on the activity of cytokine-responsive STAT transcriptional regulators. Using genetically engineered mouse models and molecular approaches, my lab has delineated roles for STATs in erythropoiesis, emergency granulopoiesis and dendritic cell development. Our current efforts are directed at understanding the mechanisms by which STATs regulate myeloid and dendritic cell function in cancer and infectious disease. We are also investigating the impact of STATs on hematopoietic regulation during inflammation.
Education & Training
Degree-Granting Education
| 1990 | Northwestern University, Evanston, IL, USA, PHD, Biochemistry, Molecular Biology and Cell Biology |
| 1983 | Carleton College, Northfield, MN, USA, BA, Biology |
Postgraduate Training
| 1990-1995 | Postdoctoral Fellow, Cellular and Molecular Biology, Whitehead Institute for Biomedical Research, Cambridge, MA |
Experience & Service
Academic Appointments
Member, Division of Graduate Faculty, MD Anderson UTHealth Graduate School, Houston, TX, 1996 - Present
Administrative Appointments/Responsibilities
Immunology Lead, PRIME TR, The University of Texas MD Anderson Cancer Center, Houston, TX, 2020 - Present
Co-Director, Center for Inflammation and Cancer (CIC), The University of Texas MD Anderson Cancer Center, Houston, TX, 2010 - Present
Director, Program in Immunology, MD Anderson UTHealth Graduate School, Houston, TX, 2004 - 2010
Other Appointments/Responsibilities
Co-Organizer, Keystone Symposium, Cytokine JAK-STAT Signaling in Immunity and Disease, Keystone Symposia, Snowmass, CO, 2016 - Present
Member, National Institutes of Health (NIH) Innate Immunity and Inflammation Study Section, Bethesda, MD, 2013 - 2017
Honors & Awards
| 2012 | Distinguished Teaching Professor, The University of Texas MD Anderson Cancer Center |
| 2010 | John P. McGovern Outstanding Teacher Award, MD Anderson UTHealth Graduate School |
| 2009 | The William Randolph Hearst Foundation Faculty Achievement Award in Education, The University of Texas MD Anderson Cancer Center |
| 2009 | Reappointment with Highest Commendation, MD Anderson UTHealth Graduate School |
Selected Publications
Peer-Reviewed Articles
- Wang J, Hasan F, Frey AC, Li HS, Park J, Pan K, Haymaker C, Bernatchez C, Lee DA, Watowich SS, Yee C. Histone deacetylase inhibitors and IL21 cooperate to reprogram human effector CD8+ T cells to memory T cells. Cancer Immunol Res 8(6):794-805, 2020. e-Pub 2020. PMID: 32213626.
- Zhou Y, Slone N, Chrisikos TT, Kyrysyuk O, Babcock RL, Medik YB, Li HS, Kleinerman ES, Watowich SS. Vaccine efficacy against primary and metastatic cancer with in vitro-generated CD103+ conventional dendritic cells. J Immunother Cancer 8(1), 2020. PMID: 32273347.
- Chrisikos TT, Zhou Y, Li HS, Babcock RL, Wan X, Patel B, Newton K, Mancuso JJ, Watowich SS. STAT3 Inhibits CD103+ cDC1 Vaccine Efficacy in Murine Breast Cancer. Cancers (Basel) 12(1), 2020. e-Pub 2020. PMID: 31947933.
- Li Y, Yang JY, Xie X, Jie Z, Zhang L, Shi J, Lin D, Gu M, Zhou X, Li HS, Watowich SS, Jain A, Yun Jung S, Qin J, Cheng X, Sun SC. Preventing abnormal NF-κB activation and autoimmunity by Otub1-mediated p100 stabilization. Cell Res 29(6):474-485, 2019. e-Pub 2019. PMID: 31086255.
- Zhang H, Li HS, Hillmer EJ, Zhao Y, Chrisikos TT, Hu H, Wu X, Thompson EJ, Clise-Dwyer K, Millerchip KA, Wei Y, Puebla-Osorio N, Kaushik S, Santos MA, Wang B, Garcia-Manero G, Wang J, Sun SC, Watowich SS. Genetic rescue of lineage-balanced blood cell production reveals a crucial role for STAT3 antiinflammatory activity in hematopoiesis. Proc Natl Acad Sci U S A 115(10):E2311-E2319, 2018. e-Pub 2018. PMID: 29463696.
- Fan F, Wang R, Boulbes DR, Zhang H, Watowich SS, Xia L, Ye X, Bhattacharya R, Ellis LM. Macrophage conditioned medium promotes colorectal cancer stem cell phenotype via the hedgehog signaling pathway. PLoS One 13(1):e0190070, 2018. e-Pub 2018. PMID: 29293549.
- Kadmon CS, Landers CT, Li HS, Watowich SS, Rodriguez A, King KY. MicroRNA-22 controls interferon alpha production and erythroid maturation in response to infectious stress in mice. Exp Hematol 56:7-15, 2017. e-Pub 2017. PMID: 28911907.
- Xiao Y, Zou Q, Xie X, Liu T, Li HS, Jie Z, Jin J, Hu H, Manyam G, Zhang L, Cheng X, Wang H, Marie I, Levy DE, Watowich SS, Sun SC. The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity. J Exp Med 214(5):1493-1507, 2017. e-Pub 2017. PMID: 28356390.
- Ni L, Wang L, Yao C, Ni Z, Liu F, Gong C, Zhu X, Yan X, Watowich SS, Lee DA, Zhu S. The histone deacetylase inhibitor valproic acid inhibits NKG2D expression in natural killer cells through suppression of STAT3 and HDAC3. Sci Rep 7:45266, 2017. e-Pub 2017. PMID: 28338101.
- Li HS, Jin J, Liang X, Matatall KA, Ma Y, Zhang H, Ullrich SE, King KY, Sun SC, Watowich SS. Loss of c-Kit and bone marrow failure upon conditional removal of the GATA-2 C-terminal zinc finger domain in adult mice. Eur J Haematol 97(3):261-70, 2016. e-Pub 2016. PMID: 26660446.
- Li HS, Liu C, Xiao Y, Chu F, Liang X, Peng W, Hu J, Neelapu SS, Sun SC, Hwu P, Watowich SS. Bypassing STAT3-mediated inhibition of the transcriptional regulator ID2 improves the antitumor efficacy of dendritic cells. Sci Signal 9(447):ra94, 2016. e-Pub 2016. PMID: 27678219.
- Caetano MS, Zhang H, Cumpian AM, Gong L, Unver N, Ostrin EJ, Daliri S, Chang SH, Ochoa CE, Hanash S, Behrens C, Wistuba II, Sternberg C, Kadara H, Ferreira CG, Watowich SS, Moghaddam SJ. IL6 blockade reprograms the lung tumor microenvironment to limit the development and progression of K-ras-mutant lung cancer. Cancer Res 76(11):3189-99, 2016. e-Pub 2016. PMID: 27197187.
- Huang X, Li J, Dorta-Estremera S, Di Domizio J, Anthony SM, Watowich SS, Popkin D, Liu Z, Brohawn P, Yao Y, Schluns KS, Lanier LL, Cao W. Neutrophils regulate humoral autoimmunity by restricting interferon-γ production via the generation of reactive oxygen species. Cell Rep 12(7):1120-32, 2015. e-Pub 2015. PMID: 26257170.
- Mao F, Xu M, Zuo X, Yu J, Xu W, Moussalli MJ, Elias E, Li HS, Watowich SS, Shureiqi I. 15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway. FASEB J 29(6):2359-70, 2015. e-Pub 2015. PMID: 25713055.
- Zhang H, Hu H, Greeley N, Jin J, Matthews AJ, Ohashi E, Caetano MS, Li HS, Wu X, Mandal PK, McMurray JS, Moghaddam SJ, Sun SC, Watowich SS. STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13. Nat Commun 5:5798, 2014. e-Pub 2014. PMID: 25503582.
- Zhu S, Phatarpekar PV, Denman CJ, Senyukov VV, Somanchi SS, Nguyen-Jackson HT, Mace EM, Freeman AF, Watowich SS, Orange JS, Holland SM, Lee DA. Transcription of the activating receptor NKG2D in natural killer cells is regulated by STAT3 tyrosine phosphorylation. Blood 124(3):403-11, 2014. e-Pub 2014. PMID: 24891320.
- Zou Q, Jin J, Hu H, Li HS, Romano S, Xiao Y, Nakaya M, Zhou X, Cheng X, Yang P, Lozano G, Zhu C, Watowich SS, Ullrich SE, Sun SC. USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses. Nat Immunol 15(6):562-70, 2014. e-Pub 2014. PMID: 24777531.
- Munoz J, Dhillon N, Janku F, Watowich SS, Hong DS. STAT3 inhibitors: finding a home in lymphoma and leukemia. Oncologist 19(5):536-44, 2014. e-Pub 2014. PMID: 24705981.
- Li HS, Watowich SS. Assessing the development of murine plasmacytoid dendritic cells in Peyer's patches using adoptive transfer of hematopoietic progenitors. J Vis Exp(85), 2014. e-Pub 2014. PMID: 24686788.
- Jin J, Hu H, Li HS, Yu J, Xiao Y, Brittain GC, Zou Q, Cheng X, Mallette FA, Watowich SS, Sun SC. Noncanonical NF-κB pathway controls the production of type I interferons in antiviral innate immunity. Immunity 40(3):342-54, 2014. PMID: 24656046.
- Yang XO, Zhang H, Kim BS, Niu X, Peng J, Chen Y, Kerketta R, Lee YH, Chang SH, Corry DB, Wang D, Watowich SS, Dong C. The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation. Nat Immunol 14(7):732-40, 2013. e-Pub 2013. PMID: 23727894.
- Liu C, Peng W, Xu C, Lou Y, Zhang M, Wargo JA, Chen JQ, Li HS, Watowich SS, Yang Y, Tompers Frederick D, Cooper ZA, Mbofung RM, Whittington M, Flaherty KT, Woodman SE, Davies MA, Radvanyi LG, Overwijk WW, Lizée G, Hwu P. BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice. Clin Cancer Res 19(2):393-403, 2013. e-Pub 2012. PMID: 23204132.
- Nguyen-Jackson HT, Li HS, Zhang H, Ohashi E, Watowich SS. G-CSF-activated STAT3 enhances production of the chemokine MIP-2 in bone marrow neutrophils. J Leukoc Biol 92(6):1215-25, 2012. e-Pub 2012. PMID: 23024284.
- Li HS, Yang CY, Nallaparaju KC, Zhang H, Liu YJ, Goldrath AW, Watowich SS. The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development. Blood 120(22):4363-73, 2012. e-Pub 2012. PMID: 23033267.
- Nurieva RI, Podd A, Chen Y, Alekseev AM, Yu M, Qi X, Huang H, Wen R, Wang J, Li HS, Watowich SS, Qi H, Dong C, Wang D. STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function. J Biol Chem 287(14):11234-9, 2012. e-Pub 2012. PMID: 22318729.
- Li HS, Greeley N, Sugimoto N, Liu YJ, Watowich SS. miR-22 controls Irf8 mRNA abundance and murine dendritic cell development. PLoS One 7(12):e52341, 2012. e-Pub 2012. PMID: 23251709.
- Yang CY, Best JA, Knell J, Yang E, Sheridan AD, Jesionek AK, Li HS, Rivera RR, Lind KC, D'Cruz LM, Watowich SS, Murre C, Goldrath AW. The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets. Nat Immunol 12(12):1221-9, 2011. e-Pub 2011. PMID: 22057289.
- Li HS, Gelbard A, Martinez GJ, Esashi E, Zhang H, Nguyen-Jackson H, Liu YJ, Overwijk WW, Watowich SS. Cell-intrinsic role for IFN-α-STAT1 signals in regulating murine Peyer patch plasmacytoid dendritic cells and conditioning an inflammatory response. Blood 118(14):3879-89, 2011. e-Pub 2011. PMID: 21828128.
- Zhang H, Nguyen-Jackson H, Panopoulos AD, Li HS, Murray PJ, Watowich SS. STAT3 controls myeloid progenitor growth during emergency granulopoiesis. Blood 116(14):2462-71, 2010. e-Pub 2010. PMID: 20581311.
- Qualls JE, Neale G, Smith AM, Koo MS, DeFreitas AA, Zhang H, Kaplan G, Watowich SS, Murray PJ. Arginine usage in mycobacteria-infected macrophages depends on autocrine-paracrine cytokine signaling. Sci Signal 3(135):ra62, 2010. e-Pub 2010. PMID: 20716764.
- Nguyen-Jackson H, Panopoulos AD, Zhang H, Li HS, Watowich SS. STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction. Blood 115(16):3354-63, 2010. e-Pub 2010. PMID: 20185584.
- Hegde S, Ni S, He S, Yoon D, Feng GS, Watowich SS, Paulson RF, Hankey PA. Stat3 promotes the development of erythroleukemia by inducing Pu.1 expression and inhibiting erythroid differentiation. Oncogene 28(38):3349-59, 2009. e-Pub 2009. PMID: 19581930.
- Speiran K, Bailey DP, Fernando J, Macey M, Barnstein B, Kolawole M, Curley D, Watowich SS, Murray PJ, Oskeritzian C, Ryan JJ. Endogenous suppression of mast cell development and survival by IL-4 and IL-10. J Leukoc Biol 85(5):826-36, 2009. e-Pub 2009. PMID: 19228815.
- Chung Y, Chang SH, Martinez GJ, Yang XO, Nurieva R, Kang HS, Ma L, Watowich SS, Jetten AM, Tian Q, Dong C. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 30(4):576-87, 2009. e-Pub 2009. PMID: 19362022.
- Yamazaki T, Yang XO, Chung Y, Fukunaga A, Nurieva R, Pappu B, Martin-Orozco N, Kang HS, Ma L, Panopoulos AD, Craig S, Watowich SS, Jetten AM, Tian Q, Dong C. CCR6 regulates the migration of inflammatory and regulatory T cells. J Immunol 181(12):8391-401, 2008. PMID: 19050256.
- Yang XO, Nurieva R, Martinez GJ, Kang HS, Chung Y, Pappu BP, Shah B, Chang SH, Schluns KS, Watowich SS, Feng XH, Jetten AM, Dong C. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29(1):44-56, 2008. e-Pub 2008. PMID: 18585065.
- Nurieva RI, Chung Y, Hwang D, Yang XO, Kang HS, Ma L, Wang YH, Watowich SS, Jetten AM, Tian Q, Dong C. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29(1):138-49, 2008. e-Pub 2008. PMID: 18599325.
- Esashi E, Wang YH, Perng O, Qin XF, Liu YJ, Watowich SS. The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8. Immunity 28(4):509-20, 2008. e-Pub 2008. PMID: 18342552.
- Kennedy Norton S, Barnstein B, Brenzovich J, Bailey DP, Kashyap M, Speiran K, Ford J, Conrad D, Watowich S, Moralle MR, Kepley CL, Murray PJ, Ryan JJ. IL-10 suppresses mast cell IgE receptor expression and signaling in vitro and in vivo. J Immunol 180(5):2848-54, 2008. PMID: 18292506.
- Yang XO, Pappu BP, Nurieva R, Akimzhanov A, Kang HS, Chung Y, Ma L, Shah B, Panopoulos AD, Schluns KS, Watowich SS, Tian Q, Jetten AM, Dong C. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity 28(1):29-39, 2008. e-Pub 2007. PMID: 18164222.
- El Kasmi KC, Smith AM, Williams L, Neale G, Panopoulos AD, Panopolous A, Watowich SS, Häcker H, Foxwell BM, Murray PJ. Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway. J Immunol 179(11):7215-9, 2007. PMID: 18025162.
- Kile BT, Panopoulos AD, Stirzaker RA, Hacking DF, Tahtamouni LH, Willson TA, Mielke LA, Henley KJ, Zhang JG, Wicks IP, Stevenson WS, Nurden P, Watowich SS, Justice MJ. Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia. Blood 110(7):2371-80, 2007. e-Pub 2007. PMID: 17515402.
- Nurieva R, Yang XO, Martinez G, Zhang Y, Panopoulos AD, Ma L, Schluns K, Tian Q, Watowich SS, Jetten AM, Dong C. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448(7152):480-3, 2007. e-Pub 2007. PMID: 17581589.
- Yang XO, Panopoulos AD, Nurieva R, Chang SH, Wang D, Watowich SS, Dong C. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem 282(13):9358-63, 2007. e-Pub 2007. PMID: 17277312.
- Panopoulos AD, Zhang L, Snow JW, Jones DM, Smith AM, El Kasmi KC, Liu F, Goldsmith MA, Link DC, Murray PJ, Watowich SS. STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils. Blood 108(12):3682-90, 2006. e-Pub 2006. PMID: 16888100.
- El Kasmi KC, Holst J, Coffre M, Mielke L, de Pauw A, Lhocine N, Smith AM, Rutschman R, Kaushal D, Shen Y, Suda T, Donnelly RP, Myers MG, Alexander W, Vignali DA, Watowich SS, Ernst M, Hilton DJ, Murray PJ. General nature of the STAT3-activated anti-inflammatory response. J Immunol 177(11):7880-8, 2006. PMID: 17114459.
- Zhang L, Badgwell DB, Bevers JJ, Schlessinger K, Murray PJ, Levy DE, Watowich SS. IL-6 signaling via the STAT3/SOCS3 pathway: functional analysis of the conserved STAT3 N-domain. Mol Cell Biochem 288(1-2):179-89, 2006. e-Pub 2006. PMID: 16718380.
- Trevino JG, Gray MJ, Nawrocki ST, Summy JM, Lesslie DP, Evans DB, Sawyer TK, Shakespeare WC, Watowich SS, Chiao PJ, McConkey DJ, Gallick GE. Src activation of Stat3 is an independent requirement from NF-kappaB activation for constitutive IL-8 expression in human pancreatic adenocarcinoma cells. Angiogenesis 9(2):101-10, 2006. e-Pub 2006. PMID: 16871430.
- Nishimoto A, Yu Y, Lu Z, Mao X, Ren Z, Watowich SS, Mills GB, Liao WS, Chen X, Bast RC, Luo RZ. A ras homologue member I directly inhibits signal transducers and activators of transcription 3 translocation and activity in human breast and ovarian cancer cells. Cancer Res 65(15):6701-10, 2005. PMID: 16061651.
- Gray MJ, Zhang J, Ellis LM, Semenza GL, Evans DB, Watowich SS, Gallick GE. HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. Oncogene 24(19):3110-20, 2005. PMID: 15735682.
- Wang L, Arcasoy MO, Watowich SS, Forget BG. Cytokine signals through STAT3 promote expression of granulocyte secondary granule proteins in 32D cells. Exp Hematol 33(3):308-17, 2005. PMID: 15730854.
- Butcher BA, Kim L, Panopoulos AD, Watowich SS, Murray PJ, Denkers EY. IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNF-alpha in host macrophages. J Immunol 174(6):3148-52, 2005. PMID: 15749841.
- Pauleau AL, Rutschman R, Lang R, Pernis A, Watowich SS, Murray PJ. Enhancer-mediated control of macrophage-specific arginase I expression. J Immunol 172(12):7565-73, 2004. PMID: 15187136.
- Yoon D, Watowich SS. Hematopoietic cell survival signals are elicited through non-tyrosine-containing sequences in the membrane-proximal region of the erythropoietin receptor (EPOR) by a Stat5-dependent pathway. Exp Hematol 31(12):1310-6, 2003. PMID: 14662339.
- Sarna MK, Ingley E, Busfield SJ, Cull VS, Lepere W, McCarthy DJ, Wright MJ, Palmer GA, Chappell D, Sayer MS, Alexander WS, Hilton DJ, Starr R, Watowich SS, Bittorf T, Klinken SP, Tilbrook PA. Differential regulation of SOCS genes in normal and transformed erythroid cells. Oncogene 22(21):3221-30, 2003. PMID: 12761492.
- Panopoulos AD, Bartos D, Zhang L, Watowich SS. Control of myeloid-specific integrin alpha Mbeta 2 (CD11b/CD18) expression by cytokines is regulated by Stat3-dependent activation of PU.1. J Biol Chem 277(21):19001-7, 2002. e-Pub 2002. PMID: 11889125.
- Afrikanova I, Yeh E, Bartos D, Watowich SS, Longmore GD. Oncogene cooperativity in Friend erythroleukemia: erythropoietin receptor activation by the env gene of SFFV leads to transcriptional upregulation of PU.1, independent of SFFV proviral insertion. Oncogene 21(8):1272-84, 2002. PMID: 11850847.
- Kubatzky KF, Ruan W, Gurezka R, Cohen J, Ketteler R, Watowich SS, Neumann D, Langosch D, Klingmüller U. Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor. Curr Biol 11(2):110-5, 2001. PMID: 11231127.
- Watowich SS, Mikami A, Busche RA, Xie X, Pharr PN, Longmore GD. Erythropoietin receptors that signal through Stat5 or Stat3 support fetal liver and adult erythropoiesis: lack of specificity of stat signals during red blood cell development. J Interferon Cytokine Res 20(12):1065-70, 2000. PMID: 11152572.
- Wooten DK, Xie X, Bartos D, Busche RA, Longmore GD, Watowich SS. Cytokine signaling through Stat3 activates integrins, promotes adhesion, and induces growth arrest in the myeloid cell line 32D. J Biol Chem 275(34):26566-75, 2000. PMID: 10858439.
- Cull V, Tilbrook PA, Adenan AS, Chappell D, Ingley E, Sarna MK, Palmer TN, Watowich SS, Klinken SP. Dominant action of mutated erythropoietin receptors on differentiation in vitro and erythroleukemia development in vivo. Oncogene 19(7):953-60, 2000. PMID: 10702804.
- Watowich SS, Xie X, Klingmuller U, Kere J, Lindlof M, Berglund S, de la Chapelle A. Erythropoietin receptor mutations associated with familial erythrocytosis cause hypersensitivity to erythropoietin in the heterozygous state. Blood 94(7):2530-2, 1999. PMID: 10498627.
- Watowich SS, Liu KD, Xie X, Lai SY, Mikami A, Longmore GD, Goldsmith MA. Oligomerization and scaffolding functions of the erythropoietin receptor cytoplasmic tail. J Biol Chem 274(9):5415-21, 1999. PMID: 10026152.
- Levin I, Cohen J, Supino-Rosin L, Yoshimura A, Watowich SS, Neumann D. Identification of a cytoplasmic motif in the erythropoietin receptor required for receptor internalization. FEBS Lett 427(2):164-70, 1998. PMID: 9607304.
- Tarr K, Watowich SS, Longmore GD. Cell surface organization of the erythropoietin receptor complex differs depending on its mode of activation. J Biol Chem 272(14):9099-107, 1997. PMID: 9083037.
- Hilton DJ, Watowich SS, Katz L, Lodish HF. Saturation mutagenesis of the WSXWS motif of the erythropoietin receptor. J Biol Chem 271(9):4699-708, 1996. PMID: 8617735.
- Murray PJ, Watowich SS, Lodish HF, Young RA, Hilton DJ. Epitope tagging of the human endoplasmic reticulum HSP70 protein, BiP, to facilitate analysis of BiP--substrate interactions. Anal Biochem 229(2):170-9, 1995. PMID: 7485969.
- Hilton DJ, Watowich SS, Murray PJ, Lodish HF. Increased cell surface expression and enhanced folding in the endoplasmic reticulum of a mutant erythropoietin receptor. Proc Natl Acad Sci U S A 92(1):190-4, 1995. PMID: 7816815.
- Watowich SS, Hilton DJ, Lodish HF. Activation and inhibition of erythropoietin receptor function: role of receptor dimerization. Mol Cell Biol 14(6):3535-49, 1994. PMID: 8196600.
- Longmore G, Watowich S, Pharr P, Neumann D, Lodish H. Activation of the erythropoietin receptor and leukemia induction in mice. Leukemia 7 Suppl 2:S113-6, 1993. PMID: 8361212.
- Neumann D, Wikström L, Watowich SS, Lodish HF. Intermediates in degradation of the erythropoietin receptor accumulate and are degraded in lysosomes. J Biol Chem 268(18):13639-49, 1993. PMID: 8514796.
- Watowich SS, Yoshimura A, Longmore GD, Hilton DJ, Yoshimura Y, Lodish HF. Homodimerization and constitutive activation of the erythropoietin receptor. Proc Natl Acad Sci U S A 89(6):2140-4, 1992. PMID: 1312714.
- Ng DT, Watowich SS, Lamb RA. Analysis in vivo of GRP78-BiP/substrate interactions and their role in induction of the GRP78-BiP gene. Mol Biol Cell 3(2):143-55, 1992. PMID: 1550958.
- Lodish HF, Hilton D, Longmore G, Watowich SS, Yoshimura A. The erythropoietin receptor: dimerization, activation, and tumorigenesis. Cold Spring Harb Symp Quant Biol 57:95-106, 1992. PMID: 1339709.
- Watowich SS, Morimoto RI, Lamb RA. Flux of the paramyxovirus hemagglutinin-neuraminidase glycoprotein through the endoplasmic reticulum activates transcription of the GRP78-BiP gene. J Virol 65(7):3590-7, 1991. PMID: 2041085.
- Watowich SS, Morimoto RI. Complex regulation of heat shock- and glucose-responsive genes in human cells. Mol Cell Biol 8(1):393-405, 1988. PMID: 3275876.
Invited Articles
- Chrisikos TT, Zhou Y, Slone N, Babcock R, Watowich SS, Li HS. Molecular regulation of dendritic cell development and function in homeostasis, inflammation, and cancer. Mol Immunol 110:24-39, 2019. e-Pub 2018. PMID: 29549977.
- Li HS, Watowich SS. Innate immune regulation by STAT-mediated transcriptional mechanisms. Immunol Rev 261(1):84-101, 2014. PMID: 25123278.
- Watowich SS. Microbial messaging to the marrow. Blood 124(9):1379-80, 2014. PMID: 25170108.
- Li HS, Watowich SS. A STATus report on DC development. J Leukoc Biol 92(3):445-59, 2012. e-Pub 2012. PMID: 22550127.
- Watowich SS. The erythropoietin receptor: molecular structure and hematopoietic signaling pathways. J Investig Med 59(7):1067-72, 2011. PMID: 21307776.
- Watowich SS, Liu YJ. Mechanisms regulating dendritic cell specification and development. Immunol Rev 238(1):76-92, 2010. PMID: 20969586.
- Esashi E, Watowich SS. Dendritic cells: transcriptional control of plasmacytoid dendritic cell development by E2-2. Immunol Cell Biol 87(1):1-2, 2009. e-Pub 2008. PMID: 19048021.
- Panopoulos AD, Watowich SS. Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and 'emergency' hematopoiesis. Cytokine 42(3):277-288, 2008. e-Pub 2008. PMID: 18400509.
- Watowich SS. Activation of erythropoietin signaling by receptor dimerization. Int J Biochem Cell Biol 31(10):1075-88, 1999. PMID: 10582340.
- Watowich SS, Wu H, Socolovsky M, Klingmuller U, Constantinescu SN, Lodish HF. Cytokine receptor signal transduction and the control of hematopoietic cell development. Annu Rev Cell Dev Biol 12:91-128, 1996. PMID: 8970723.
- Lodish HF, Hilton DJ, Klingmüller U, Watowich SS, Wu H. The erythropoietin receptor: biogenesis, dimerization, and intracellular signal transduction. Cold Spring Harb Symp Quant Biol 60:93-104, 1995. PMID: 8824381.
- Longmore GD, Watowich SS, Hilton DJ, Lodish HF. The erythropoietin receptor: its role in hematopoiesis and myeloproliferative diseases. J Cell Biol 123(6 Pt 1):1305-8, 1993. PMID: 8253831.
Book Chapters
- Zhang H, Li HS, Watowich SS. Jak-STAT signaling pathways. In: Encyclopedia of Immunobiology. Oxford: Academic Press: Oxford, UK, 134–145, 2016.
- Nguyen-Jackson H, Zhang H, Watowich SS. G-CSF receptor structure, function and intracellular signal transduction. In: 20 Years of G-CSF: Clinical and Nonclinical Discoveries. Birkhäuser Verlag AG: Basel, Switzerland, 2012.
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Grant & Contract Support
| Title: | Regulation and Function of Nonlymphoid Organ CD103+ Dendritic Cells |
| Funding Source: | NIH/NIAID |
| Role: | Principal Investigator |
| Title: | The Future of Cancer Research: Training Program for Basic and Translational Scientists |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-Principal Investigator |
| Title: | Defining Protective Responses in Hematopoietic Cells Mediated by STAT3 Anti-Inflammatory Activity |
| Funding Source: | NIH/NIAID |
| Role: | Principal Investigator |
| Title: | The Role of the PI3K Pathway in Immune Resistance – Supplement |
| Funding Source: | NIH/NCI |
| Role: | Other Significant Contributor |
| Title: | Regulation and Function of Nonlymphoid Organ CD103 Dendritic Cells – Supplement |
| Funding Source: | NIH/NIAID |
| Role: | Principal Investigator |
| Title: | Immunotherapeutic Modalities for K-ras Mutant Lung Cancer: Sex- and Cell Type-Specific Roles of IL-6/STAT3 Signaling |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| Title: | Targeting Neutrophil Elastase as a Novel Therapy for Metastatic Breast Cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Principal Investigator |
Patient Reviews
CV information above last modified April 01, 2024