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Robert Dantzer, DVM, PhD

Department of Symptom Research, Division of Internal Medicine

About Dr. Robert Dantzer

Robert Dantzer has always been intrigued by the distinction between physiology (the normal) and pathology (the abnormal) and the theories that account for transitioning from one state to the other in medicine. At the end of his veterinary studies in 1967, he joined the newly established Laboratory of Veterinary Pharmacology in Toulouse, France, where he developed medical interventions for prevention and treatment of stress in farm animals. This work motivated his scientific investment in the psychobiology of stress and the field of psychoneuroimmonology, still-nascent disciplines in the 1960s.

Dr. Dantzer moved to Bordeaux, France, in 1980 to develop a research program in the psychobiology of adaptive behavior. At the time, stress was still considered to be a nonspecific response to catastrophic events that derange homeostasis. To better understand how individuals adapt to daily life events, he focused on the bidirectional interactions between the behavioral responses to stress, the so-called "coping strategies" – and neuroendocrine responses to stress. Because stress can modulate resistance to infections, he incorporated an immune component into his studies. He quickly realized, however, that immune influences on brain functions were much more potent than brain influences on immunity. This gave rise to transformative research on the influence of immune factors on brain functions, a new field of research that revealed for the first time the neuroimmune mechanisms of sickness and depression. Rapid advances in the understanding of the molecular biology of inflammation allowed him to lay out the foundations of an objective study of why we feel sick and behave in a sick way when we are ill. Once the same mechanisms were shown to lead to depression, the field moved from the limbo of psychoneuroimmunology to the forefront of biological psychiatry.

The time was then right to test the implications of this research for other fields – in particular, the neglected field of cancer-related symptoms, which negatively affect the quality of life of millions of cancer survivors. The need for medical applications motivated Dr. Dantzer's move to MD Anderson Cancer Center in 2012. Along with Drs. Annemieke Kavelaars and Cobi Heijnen, he founded the Neuroimmunology Laboratory as a new basic science lab within the Department of Symptom Research. The lab extends the department's ongoing descriptive research and intervention trials in animal models of pain, fatigue, neuropathy and cognitive impairment.

Primary Appointment

Professor, Department of Symptom Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Adjunct Professor, Rice University, Houston, TX

Adjunct Professor, UT Health Science Center Houston, Department of Psychiatry and Behavioral Sciences, Houston, TX

Professor, Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1977	University Paul Sabatier, Toulouse, FR, Ph.D. in Behavioral Neuroscience
1971	University Paris VI, Paris, FR, Dr. 3rd Cycle in Behavioral Neuroscience
1967	University Paul Sabatier, Toulouse, FR, DVM in Veterinary Medicine

Experience & Service

Faculty Academic Appointments

Professor, Department of Psychoneuroimmunology, University of Illinois at Urbana-Champaign, Champaign, IL, 2006 - 2011

Head, Laboratory of Integrative Neurobiology, University of Bordeaux II - French National Center of Scientific Research (CNRS), Bordeaux, 2004 - 2006

Adjunct Professor, Department of Psychoneuroimmunology, University of Illinois at Urbana-Champaign, Champaign, IL, 2003 - 2006

Head of Laboratory of Integrative Neurobiology, INSERM U394, Bordeaux, 1994 - 2003

Acting Head, Department of Laboratory of Integrative Neurobiology, INSERM U176 Lab, Bordeaux, 1991 - 1993

Director of Research 1st class, French National Institute of Agronomic Research (INRA), Paris, 1989 - 2006

Director of Research 2nd class, Department of Laboratory of Psychobiology of Adaptive Behavior, French National Institute of Medical Research (INSERM), Bordeaux, 1983 - 1988

Director of Research 2nd class, Department of Laboratory of Behavioral Neurobiology, University of Bordeaux II, Bordeaux, 1980 - 1982

Director of Research 2nd class, Department of Laboratory of Veterinary Pharmacology, French National Institute of Agronomic Research (INRA), Toulouse, 1979 - 1980

Research Scientist, Department of Laboratory of Veterinary Pharmacology, French National Institute of Agronomic Research (INRA), Toulouse, 1971 - 1979

Research Assistant, Department of Pharmacology, French National Institute of Agronomic Research (INRA), Toulouse, 1968 - 1971

Administrative Appointments/Responsibilities

Deputy Chair, Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2012 - 2020

Other Professional Positions

Consultant, GoodCap Pharma, Toronto, Ontario, 2022 - Present

Consultantships, Ironwood Pharma, USA, Cambridge, MA, 2013 - 2014

Consultantships, Lundbeck, USA, 2009 - 2011

Consultantships, Bristol Myers Squibb, USA, 2009 - 2010

Consultantships, Astra-Zeneca, USA, 2008 - 2009

Consultantships, Unilever, UK, 2007 - 2008

Consultantships, Danone, France, 2005 - 2007

Consultantships, Nestlé, Switzerland, 2003 - 2005

Consultantships, SERVIER, France, 2000 - 2005

Consultantships, LEBRUN, France, 1988 - 1990

Consultantships, SANOFI Drug Research, France, 1985 - 1988

Intramural Institutional Committee Activities

Member, Distinguished Paper Award, The University of Texas MD Anderson Cancer Center, 2024 - Present

Chair, Distinguished Paper Award, The University of Texas MD Anderson Cancer Center, 2021 - 2023

Chair, IRG Basic Science, The University of Texas MD Anderson Cancer Center, 2015 - 2012

Member, DoIM Research Committee, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, 2015 - Present

Vice Chair, IRG Basic Science, The University of Texas MD Anderson Cancer Center, 2014 - 2015

Editorial Activities

Editor-in-Chief, Comprehensive Psychoneuroendocrinology, 2020 - 2025

Associate Editor, Pharmacological Reviews, 2016 - 2025

Editorial Board, Journal of Affective Disorders, 2015 - Present

Editorial Board, European Journal of Pharmacology, 2002 - 2012

Associate Editor, Brain, Behavior and Immunity, 2000 - 2012

Editorial Board, Physiology & Behavior, 1998 - 2008

Editorial Board, Stress, 1997 - 2006

Editorial Board, Molecular Psychiatry, 1996 - 2001

Editorial Board, Neuroimmunomodulation, 1995 - Present

Associate Editor, Behavioural Processes, 1995 - 2003

Editor-in-Chief, Psychoneuroendocrinology, 1992 - 2022

Editorial Board, Behavioural Pharmacology, 1989 - 2000

Associate Editor, Brain, Behavior, and Immunity, 1986 - 2006

Editorial Board, Neuroscience Research Communications, 1985 - 2004

Honors & Awards

2025 - Present	Henri Le Bars Prize of Integrative Physiology, French Veterinary Academy
2025 - Present	Bruce McEwen Lifetime Achievement Award, International Society of Psychoneuroendocrinology
2025 - Present	George G Solomon Award Lecture, Psychoneuroimmunology Research Society
2024	Robert E. Gagel Lifetime Achievement Award, Division of Internal Medicine, UT MD Anderson Cancer Center
2017 - 2018	2017 Distinguished Investigator Award, Brain & Behavior Research Foundation
2017	Gold Medal, French Academy of Agriculture
2015 - 2016	New Investigator Development Program Mentor, UTHealth
2015	Distinguished Mentor Award 2015 Finalist, The MD Anderson Postdoctoral Association
2015	Service Award, International Society of Psychoneuroendocrinology
2015	Xiaohong Wang Memorial Lecture, Department of Psychiatry & Behavioral Sciences, Emory University
2000	Norman Cousins Memoria Award, Psychoneuroimmunology Research Society
1991	National ASAS Animal Management Award, American Society of Animal Science, Merck Sharp & Dome

Professional Memberships

American Society for Pharmacology and Experimetnal Therapeutics

2019 - 2025

American Psychosomatic Society

2006 - 2008

European Collegium of Neuropsychopharmacology

2006 - 2008

International Society of Psychoneuroendocrinology

1993 - Present

PsychoNeuroImmunology Research Society

1992 - Present

French Society of Biological Psychiatry

1990 - 1991

International Society for NeuroImmunoModulation (ISNIM)

1990 - 1991

French Society of Neurosciences

1990 - Present

European Society of Behavioral Pharmacology

1986 - 1990

Selected Presentations & Talks

Local Presentations

2020. The conundrum of cancer-related fatigue. Conference. The conundrum of cancer-related fatigue. Houston, TX, US.
2015. Neurobehavioral toxicities of cancer therapy. Conference. Neurobehavioral toxicities of cancer therapy. Houston, TX, US.
2015. Pathophysiology of cancer-related symptoms in human papilloma virus-related head and neck cancer. Conference. Pathophysiology of cancer-related symptoms in human papilloma virus-related head and neck cancer. Houston, TX, US.

National Presentations

2025. Tumor-to-Brain Communication Pathways in the Pathophsyiology of Cancer-Related Symptoms: The Case of Fatigue. Invited. MSU Department of Neurosciences and Physiology Seminar Series. East Lansing, MI, US.
2023. How does the tumor communicate with the brain to induce fatigue?. Invited. Annual Symposium of the Center for Cancer Biology Research. Sioux Falls, SD, US.
2023. What sexual health specialists can learn from the study of sickness behavior. Conference. What sexual health specialists can learn from the study of sickness behavior. Saint-Louis, MO, US.
2021. Approaches to study the biology of fatigue in preclinical models, presented in the workshop "Beyond the symptom: Biology of fatigue". Conference. Approaches to study the biology of fatigue in preclinical models, presented in the workshop "Beyond the symptom: Biology of fatigue". zoom meeting, US.
2019. Inflammation-associated depression: a view from the blood-brain barrier side. Conference. Inflammation-associated depression: a view from the blood-brain barrier side. Seattle, WA, US.
2019. Inflammation and Depression: What symptoms is inflammation responsible for?. Conference. Inflammation and Depression: What symptoms is inflammation responsible for?. Chicago, IL, US.
2018. Do immune-to-brain communication pathways play a role in cancer-cachexia. Conference. Pfizer. Cambridge, MA, US.
2018. The neuroimmune basis of fatigue: how does inflammation induce fatigue. Conference. The neuroimmune basis of fatigue: how does inflammation induce fatigue. Washington, DC, US.
2018. The neuroimmune basis of fatigue. Conference. The neuroimmune basis of fatigue. Los Angeles, CA, US.
2018. What have we learned about cancer-related fatigue from experimental approaches. Conference. What have we learned about cancer-related fatigue from experimental approaches. Louisville, KY, US.
2017. Role of Inflammation in Comorbid Pain and Depression. Conference. Society of Biological Psychiatry. San Diego, CA, US.
2016. Clinical Roundtable: The Subcortical Source of Inflammatory Malaise. Conference. Society of Neuroscience. San Diego, CA, US.
2016. Symposium on Mood Disorders at the Cross Roads of Neuroimmunology. Conference. Society of Biological Psychiatry. Atlanta, GA, US.
2016. Conference on Diagnosis, Mechanisms, and Management of Cancer Treatment-Induced Neurotoxicities : Neuropathy, Fatigue, and Cognitive Impairment. Conference. Conference on Diagnosis, Mechanisms, and Management of Cancer Treatment-Induced Neurotoxicities : Neuropathy, Fatigue, and Cognitive Impairment. Houston, TX, US.
2015. Transduction of peripheral cytokine signals to the brain and its relevance to schizophrenia phenotypes. Conference. Transduction of peripheral cytokine signals to the brain and its relevance to schizophrenia phenotypes. Colorado Springs, CO, US.
2015. Inflammation-induced depression: an insight into immunopsychiatry. Conference. UTHealth, 1st Annual Immunopsychiatry Meeting. Houston, TX, US.
2013. Inflammation to Sickness and Depression: When the Immune System Subjugates the Brain. Conference. Laureate Institute for Brain Research. Tulsa, OK, US.
2012. The Role of Inflammation as a Bridge Between Depression and Diabetes: Lesson From Animal Models. Conference. NIH-NIDDK. Washington, DC, US.
2012. Chair of the Session on Neurobehavioral Toxicity, Presentation, Mechanisms of Inflammation-Induced Depression. Conference. The University of Texas MD Anderson Cancer Center. Houston, TX, US.
2011. Why do we feel sick and behave in a sick way when we are ill?. Conference. Endocrinology Society. Boston, MA, US.
2009. From inflammation to sickness and depression: the role of cytokines. Conference. Lyme Conference. Washington, DC, US.
2009. Neurobiology of Disease, Workshop on Neurobiology of Depression, Neuroimmunological approaches. Conference. NIMH. Chicago, IL, US.
2009. Psychoneuroimmunological mechanisms of fatigue. Conference. NIH National Institute of Aging. Bethesda, MD, US.
2008. Mechanisms of cytokine-induced depression. Conference. CINP. Scottsdale, AZ, US.
2008. Cytokine-induced depression. Conference. American Psychosomatic Society. Baltimore, MD, US.
2007. Cytokines and well-being. Conference. Unilever. New York, NY, US.
2006. Psychoneuroimmune perspective on somatization. Conference. Glaxo Smith Kline. Dallas, TX, US.

International Presentations

2025. Brain-body interactions: stress, sickness, and depression. Invited. President's meeting, French Veterinary Academy. Paris, FR.
2025. From psychoneuroendocrinology to psychoneuroimmunology. Invited. 2025 Annual meeting of the International Society of Psychoneuroendocrinology. New Orleans, US.
2025. How the immune system speaks to the brain: sickness, depression, and beyond. Invited. Symposium on Neuroimmune Crosstalk in Brain/Body Interacitons. Paris, FR.
2025. When the immune system subjugates the brain. Invited. 2025 Annual meeting of the Psychoneuroimmunology Research Society. Bordeaux, FR.
2025. Inflammation from sickness to depression, and now what?. Invited. 2025 Annual meeting of the Psychoneuroimmunology Research Society. Bordeaux, FR.
2025. Role of the GDF15-GFRAL axis in fatigue and cognitive impairment induced by cellular stress. Panelist. 2025 International Conference on Frailty and Sarcopenia Research. Toulouse, FR.
2023. What do animal models of inflammation-induced depression bring to precision psychiatry. Conference. What do animal models of inflammation-induced depression bring to precision psychiatry. Crans-Montana, CH.
2022. Role of the GDF15/GFRAL axis in cancer-related fatigue. Poster. Role of the GDF15/GFRAL axis in cancer-related fatigue. Zurich, CH.
2019. How the Immune System Subjugates the Brain. Conference. How the Immune System Subjugates the Brain. Paris, FR.
2019. Neuroinflammation does not mediate fatigue induced by tumor growth in an inflammatory murine model of lung cancer. Conference. Neuroinflammation does not mediate fatigue induced by tumor growth in an inflammatory murine model of lung cancer. Berlin, DE.
2018. Targeting the blood-brain barrier to treat inflammation-induced depression. Conference. Targeting the blood-brain barrier to treat inflammation-induced depression. Hikone, JP.
2018. Inflammation, depression, and response to therapy. Conference. 113th Course on Neuroimmunology. Bordeaux, FR.
2018. Psychoneuroimmunology: concepts and theories. Conference. ImmunoConcept. Bordeaux, FR.
2017. Immune-to-Brain Communication Pathways in Inflammation-Induced Sickness Behavior and Depression. Conference. Basel University, Switzerland. Basel, CH.
2017. Motivational Aspects of Inflammation-Associated Fatigue. Conference. Royal Society, London, UK. Chicheley Hall, Buckinghamshire, GB.
2017. New Targets in Depression: A view from the Immune-to-Brain Communication Pathways. Conference. New Targets in Depression: A view from the Immune-to-Brain Communication Pathways. Zurich, CH.
2017. Neuroimmune Mechanisms of Inflammation-Associated Depression. Conference. University of Bonn, Germany. Bonn, DE.
2017. Le serpent de mer de l'immunopsychiatrie: les liens entre inflammation et depression (Immunopsychiatry: The Relationships between inflammation and depression). Conference. Encephale, Paris, France. Paris, FR.
2016. Is inflammation responsible for cancer-related symptoms?. Conference. Is inflammation responsible for cancer-related symptoms?. San Juan, PR.
2016. Neuroimmune Mechanisms of Induction and Resolution of Inflammation-Associated Depression. Conference. Pasteur Institute, Paris, France. Paris, FR.
2016. Immunite, Cerveau and Troubles Psychiatriques: Une Question de Communication (Immunity, Brain, and Psychiatric Disorders: A Question of Communication). Conference. Fondation Fondamental, Créteil, France. Creteil, FR.
2015. Mechanisms of Behavioral Alterations Induced in Mice by HPV-Related Head and Neck Cancer and its Treatment. Conference. Mechanisms of Behavioral Alterations Induced in Mice by HPV-Related Head and Neck Cancer and its Treatment. Placenzia, BZ.
2015. Inflammation-induced depression: evidence and mechanisms. Conference. Brazilian Society of Psychiatry. Florianopolis, BR.
2015. Role of indoleamine 2,3 dioxygenase activation in inflammation-induced depression. Conference. European College of Neuropsychopharmacology. Amsterdam, NL.
2015. Immune-to-brain interactions in the development of sickness and depression. Conference. European Association of Psychosomatic Medicine. Nuremberg, DE.
2015. Inflammatory models of depression in rodents: relevance to antidepressant drug discovery?. Conference. CINP. Dublin, IE.
2015. Is depression the manifestation of an inflamed brain?. Conference. University of Calgary. Calgary, CA.
2015. Inflammation-induced depression. Conference. CINP. Dublin, IE.
2015. Inflammation-induced depression. Conference. ECNP. Amsterdam, NL.
2015. Cytokine-induced sickness and depression. Conference. University of Calgary. Calgary, CA.
2014. Inflammation-induced depression: Evidence and mechanisms. Conference. International Society of Neuroimmunology. Mainz, DE.
2014. Inflammation-Induced Depression: Where Do We Stand? (plenary lecture). Conference. International Society for Neuroimmumodulation. Liege, BE.
2014. The neuroimmune basis of fatigue, Anne Faulkner Lecture. Conference. Medical Research Council, UK. Bristol, GB.
2014. Inflammation and Depression: Where do we Stand?. Conference. European Behavioral Pharmacology Society. Brighton, GB.
2014. Inflammation and Depression. Conference. Pfizer Dermatology-Inflammation. Lyon, FR.
2014. The Neuroimmune Basis of Fatigue, Anne Faulkner Lecture. Conference. UK CFS/ME Research. Bristol, GB.
2014. Keynote: Inflammation and depression: where do we stand?. Conference. European Behavioral Pharmacology Society and Brighton and Sussex Medical School. Brighton, GB.
2013. Inflammation and Psychiatry: A Primer. Conference. Neuroscience School of Advanced Studies. Cortona, IT.
2013. Inflammation, Depression and Response to Therapy, 13th Course on Neuroimmunology: The Immune System Meets the Mind: Psychobiology and Psychoneuroimmunology. Conference. International Society of Neuroimmunology. Bergamo, IT.
2013. Chronic Activation of Inflammatory Signaling Pathways in the Central Nervous System is a Major Pathological Process in a Kaleidoscope of Neurological and Psychiatric Diseases. Conference. Yaffo Technical College. Tel Aviv, IL.
2012. Kynurenines in Depression: From the Bedside to the Bench and Vice-Versa. Conference. International Society of Trytophan Research. Sydney, AU.
2012. Pathophysiology of Inflammation-Associated Depression. Conference. German Association for Psychiatry and Psychotherapy. Berlin, DE.
2012. Cytokines in Central Nervous System Physiology and Pathology. Conference. Summer School of Neuroscience, Neuroinflammation in Central Nervous System Disorders: Priming a Target for New Therapies. Catania, IT.
2012. Co-Chair of the Symposium on Psychoneuroimmunology: Cytokines and Psychiatric Illness, Inflammation-Induced Depression: Evidence and Mechanisms. Conference. CINP. Stockholm, SE.
2012. Inflammation-Induced Depression: Where Do We Stand?. Conference. Inflammation-Induced Depression: Where Do We Stand?. Gunzburg, DE.
2009. Inaugural Address: From Inflammation to Sickness and Depression. Conference. Phytotherapy Congress. Paris, FR.
2009. From inflammation to depression: a role of indoleamine 2,3 dioxygenase. Conference. 9th World Congress of Biological Psychiatry. Paris, FR.
2008. What to do with behavior in behavioral sciences?. Conference. National Institute of Agronomic Research INRA. Paris, FR.
2008. Inflammation and depression: is there a role for serotonin?. Conference. British Society of Pharmacology. Brighton, GB.
2007. Psychoneuroimmunology. Conference. The Hebrew University of Jerusalem. Jerusalem, IL.
2007. Cytokines and depression: what are the intermediate mechanisms?. Conference. Institute of Psychiatry, King's College, London. London, GB.
2007. Inflammation, cytokines, and symptoms in physically iill patients. Conference. Association pour la Neuropsychopharmacologie, Servier Institute. Bordeaux, FR.
2006. Psychoneuroimmune perspectives on somatization. Conference. American Psychiatry Association. Beijing, CN.
2005. Neuroimmunological approaches to healthy aging. Conference. Nestle. Lausanne, CH.
2003. Brain effects of cytokines: from sickness behavior to depression. Conference. Graduate School of Psychobiology Luxembourg. Luxembourg, LU.

Formal Peers

2023. Inflammation, sickness and depression; how the immune system subjugates the brain. Invited. Manhasset, NY, US.
2022. Inflammation is not always the culprit: the case of cancer-related fatigue. Invited. London, Ontario, CA.
2022. An introduction to psychoneuroimmunology. Invited. Giessen, DE.
2018. Pyschoneuroimmunology: Concepts and Theories. Invited. Charlottesville, VA, US.
2018. From Inflammation to Sickness and Depression. Invited. Augusta, GA, US.
2018. The metabolic basis of cancer-related fatigue. Invited. Los Angeles, CA, US.
2017. From Stress in Farm Animals to ImmunoPsychiatry: 50 Years of Research. Invited. Paris, FR.
2017. Resilience: From Human to Animal Studies. Invited. New York, NY, US.
2017. Motivational Aspects of Inflammation-Induced Depression. Invited. Paris, FR.
2016. Inflammation, Fatigue, and Depression: A Neuroimmune Perspective, Neuroscience Program University of Illnois. Invited. Urbana-Champaign, IL, US.
2015. Inflammation-induced depression: evidence, mechanisms, and implications. Invited. Dallas, TX, US.
2015. Inflammation and depression: where do we stand?. Invited. Atlanta, GA, US.
2014. Neurobehavioral toxicities of cancer treatment. Invited. Chicago, IL, US.
2014. Immune influences on the brain: from neuroimmunology to immunopsychiatry. Invited. Houston, TX, US.
2014. Why do we feel sick and behave in a sick way when we are ill?. Invited. Houston, TX, US.
2014. Cancer-related symptoms: a neuroimmune perspective. Invited. Bethesda, MD, US.
2014. From inflammation to sickness and depression: how the immune system subjugates the brain. Invited. Ann Arbor, MI, US.
2013. Inflammation, sickness and depression: when the immune system subjugates the brain. Invited. Austin, TX, US.
2013. From inflammation to sickness and depression: when the immune system subjugates the brain. Invited. Tulsa, OK, US.
2012. Why we feel sick when we are ill: a story of immune-to-brain communication. Invited. Philadelphia, PA, US.
2012. From inflammation to sickness and depression: how the immune system subjugates the brain. Invited. Amsterdam, NL.
2009. Why do we feel sick and behave in a sick way when we are well? A case of immune-to-brain communication. Invited. San Antonio, TX, US.
1986. Professional Stay. Invited. Urbana, IL, US.
1973. Professional Stay. Invited. Cambridge, GB.
1972. Professional Stay. Invited. Oxford, GB.
1970. Professional Stay. Invited. Paris, FR.
1967. Professional Stay. Invited. Toulouse, FR.

Less

Grant & Contract Support

Date:	2025 - Present
Title:	Role of sensory nerves in the impact of cancer on neurobehavioral health
Funding Source:	Cancer Neuroscience Program MDACC
Role:	PI

Date:	2024 - 2026
Title:	Targeting GDF15 and its receptor to treat cancer-related fatigue
Funding Source:	NIH/NCI
Role:	PI
ID:	1R21CA291320

Date:	2024 - 2029
Title:	ROLE OF THE GDF15/GFRAL AXIS IN CHRONIC ILLINESS-RELATED SYMPTOMS
Funding Source:	NIH/NINDS
Role:	PI
ID:	1R01NS138321-01

Date:	2024 - 2027
Title:	Pathophysiological role of growth differentiation factor 15 (GDF15) in cancer-related fatigue
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	PI
ID:	RP240067

Date:	2023 - 2025
Title:	Targeting mitokines to treat cancer-related fatigue
Funding Source:	NIH/NCI
Role:	PI
ID:	R21 CA279246

Date:	2023 - 2028
Title:	Nature and Functionality of the Cancer-Brain Circuit
Funding Source:	NIH/NCI
Role:	Co-PI
ID:	R01 NS128650

Date:	2022 - 2023
Title:	Targeting the GDF/GFRAL Axis to Treat Cancer-Related Fatigue
Funding Source:	Thrive HESI
Role:	PI

Date:	2022 - 2024
Title:	Mitokines as new targets for fatigue induced by mitochondrial stress
Funding Source:	NIH/NINDS
Role:	PI
ID:	R21 NS130712

Date:	2022 - 2027
Title:	NoMoreCACHEXIA
Funding Source:	University of Alberta
Role:	Co-I
ID:	FP00014446

Date:	2021 - 2026
Title:	The Neuroimmune Basis of Inflammation-Induced Motivational Anhedonia
Funding Source:	NIH/NIMH
Role:	PI
ID:	R01 NIMH 12897

Date:	2020 - 2022
Title:	The Neuroimmune Basis of New Onset Depressive Symptoms in Acute Illness
Funding Source:	NIH/NCI
Role:	PI
ID:	R21 NR019727

Date:	2020 - 2021
Title:	Neuroimmune Mechanisms of New Onset Depressive Symptoms in Acute Illness
Funding Source:	The University of Texas MD Anderson Cancer Center IRG Program
Role:	PI
ID:	001IRG

Date:	2020 - 2022
Title:	The Neuroimmune Basis of Depression
Funding Source:	NIH/NCI
Role:	PI
ID:	R21MH122953

Date:	2019 - 2024
Title:	The Metabolic Basis of Inflammation-Induced Depression
Funding Source:	NIH/NIMH
Role:	PI
ID:	R01 MH121940

Date:	2019 - 2021
Title:	Optimizing the stability and duodenal delivery of oral amifostine for intestinal radioprotection during ablative radiotherapy
Funding Source:	William Marsh Rice University
Role:	Co-I
ID:	FP00007444

Date:	2019 - 2025
Title:	The Metabolic Basis of Cancer-Related Fatigue
Funding Source:	NIH/NCI
Role:	PI
ID:	R01CA193522

Date:	2018 - 2023
Title:	PQ12 Metabolic Mechanisms of Cancer-Related Fatigue
Funding Source:	NIH/NCI
Role:	PI
ID:	R01CA226221

Date:	2018 - 2019
Title:	Motivational Basis of Inflammation Induced Depression
Funding Source:	Brain & Behavior Research Foundation
Role:	PI
ID:	26881

Date:	2017 - 2018
Title:	Role of Exosomes in Tumor Host Interactions
Funding Source:	The University of Texas MD Anderson Cancer Center IRG
Role:	PI

Date:	2017 - 2022
Title:	Mechanisms of Tumor-Neural Communication in Head and Neck Squamous-Cell Carcinoma
Funding Source:	Sanford Health
Role:	Principal Investigator-MDACC
ID:	R01 CA218328

Date:	2017 - 2022
Title:	Neuroimmune Mechanisms of Post-Sepsis Cognitive Dysfundtion
Funding Source:	University of Texas Health Science Center
Role:	Principal Investigator-MDACC
ID:	R01 AI133468

Date:	2017 - 2022
Title:	Mitochondrial Damage and Neuroinflammation in Chemobrain
Funding Source:	NIH/NCI
Role:	Co-I
ID:	R01CA214619

Date:	2017 - 2019
Title:	Mechanisms of Antidepressant Properties of L-Leucine
Funding Source:	Ajinomoto Innovation Alliance Program
Role:	PI
ID:	5199

Date:	2016 - 2022
Title:	Neuroimmune Mechanisms of Recovery from Comorbid Depression and Chronic Pain
Funding Source:	NIH/NINDS
Role:	Co-PI
ID:	R01NS073939

Date:	2016 - 2021
Title:	Neuroimmune Mechanisms of Recovery from Comorbid Depression and Chronic Pain
Funding Source:	NIH/NINDS
Role:	Co-PI
ID:	2R01NS073939

Date:	2016 - 2021
Title:	Targeting Mitochondrial Damage and Neuroinflammation to Prevent Chemobrain
Funding Source:	NIH/NCI
Role:	Co-I
ID:	R01CA200902

Date:	2016 - 2021
Title:	The Physiopathology of Long-Term Cognitive Impairment in Sepsis Survivors
Funding Source:	UT Health Science Center Houston
Role:	Principal Investigator-MDACC
ID:	R01AI118797

Date:	2015 - 2016
Title:	Early Detection of Neurotoxicities Associated with Cancer Treatment: Exploratory Studies in Cancer Patients and Validation in a Mouse Model
Funding Source:	The Red and Charline McCombs Institute Center
Role:	Co-I
ID:	0004

Date:	2015 - 2020
Title:	Neurobehavioral Toxicities of Treatment for Head and Neck Cancer
Funding Source:	NIH/NCI
Role:	Co-PI
ID:	P01CA1965222

Date:	2015 - 2020
Title:	Neuroimmune Basis of Fatigue
Funding Source:	NIH/NCI
Role:	PI
ID:	R01CA196800

Date:	2015 - 2020
Title:	Translational Studies to Reduce Fatigue, Pain and Other Symptoms in Patients Treated for Head and Neck Cancer
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	Project Leader
ID:	RP150554

Date:	2015 - 2016
Title:	Neuroimmune Mechanisms of Cancer-Related Symptoms in Oral Squamous Cell Carcinoma (OSCC)
Funding Source:	NIH/NCI
Role:	PI
ID:	R01CA193522

Date:	2015 - 2018
Title:	Blood-Brain Barrier Transport Mechanisms in Inflammation-Induced Depression
Funding Source:	NIH/NIMH
Role:	PI
ID:	R21 MH104694

Date:	2015 - 2019
Title:	Neuroimmune Mechanisms of Cancer-Related Symptoms in Oral Squamous Cell Carcinoma
Funding Source:	NIH/NCI
Role:	PI
ID:	R01CA193522-03S1

Date:	2014 - 2017
Title:	Targeting Neural Mitochondria to Treat Chemotherapy-Induced Peripheral Neuropathy
Funding Source:	NIH/NCI
Role:	Co-Program Leader
ID:	R21CA183736

Date:	2014 - 2017
Title:	A New Translational Approach to the Mechanisms of Cancer-Related Fatigue
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	PI

Date:	2014 - 2016
Title:	Improving Quality of Life of Cancer Survivors Through Identification of Treatment Targets for Cancer-Related Fatigue
Funding Source:	The University of Texas MD Anderson Cancer Center Cancer Survivorship
Role:	PI

Date:	2014 - 2019
Title:	Mechanisms of Symptoms of Therapy in Head and Neck Cancer
Funding Source:	NIH/NCI
Role:	PI
ID:	P01CA124787

Date:	2014 - 2019
Title:	Neuroimmune Mechanisms of Cancer-Related Symptoms in Oral Squamous Cell Carcinoma
Funding Source:	NIH/NCI
Role:	PI
ID:	R01 CA1833338

Date:	2013 - 2018
Title:	Examining and Preventing Health Consequences of Everyday Discrimination
Funding Source:	NIH/NIMH
Role:	Co-I
ID:	R01 MD007758

Date:	2013 - 2016
Title:	Targeting Inflammation by Minocycline to Treat Symptoms in CRC Patients
Funding Source:	American Cancer Society (ACS)
Role:	Co-I
ID:	RSG PCSM 124286

Date:	2012 - 2015
Title:	Examining and Preventing Cancer-related Consequences of Everyday Discrimination
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	Co-I

Date:	2012 - 2017
Title:	Cancer-Related Fatigue: Center of Excellence in Symptom Science
Funding Source:	NIH/NINR
Role:	PI
ID:	P20 NR14145

Date:	2012 - 2014
Title:	Inflammation-Induced Behavioral Alterations: A Psychogenomic Approach
Funding Source:	NIH/NCI
Role:	Investigator
ID:	R21 MH096030

Date:	2011 - 2016
Title:	A novel molecular switch regulating transition from acute to chronic pain
Funding Source:	NIH/NINDS
Role:	Co-I
ID:	R01 NS074999

Date:	2011 - 2016
Title:	A Novel Neuroimmune Risk Factor for Comorbid Depression and Chronic Pain
Funding Source:	NIH/NINDS
Role:	Co-PI
ID:	R01 NS073939

Date:	2010 - 2015
Title:	Biobehavioral Role of Brain Kynurenine Metabolism in Mental Illness
Funding Source:	NIH/NIMH
Role:	Consult
ID:	R01 MH090127

Date:	2010 - 2013
Title:	Interventions that target neuroinflammation in Gulf War Illness
Funding Source:	Department of Defense (DOD)
Role:	Co-PI

Date:	2008 - 2014
Title:	Mechanisms of Symptoms of Multiple Myeloma and Its Therapy
Funding Source:	NIH/NCI
Role:	Project Leader
ID:	P01 CA124787

Date:	2008 - 2013
Title:	Neuroimmunology and Behavior: Natural Antagonism of Sickness and Depression
Funding Source:	NIH/NIMH
Role:	Collaborator
ID:	R01 MH083767

Date:	2007 - 2009
Title:	Methamphetamine, HIV, neuroinflammation and behavior
Funding Source:	NIH/NIDA
Role:	Co-I
ID:	R21 DA024443

Date:	2007 - 2014
Title:	Neuroimmune Mechanisms of Depressive-Like Behavior During Aging
Funding Source:	NIH/NIA
Role:	Co-I
ID:	R01 AG029573

Date:	2006 - 2012
Title:	AIDS, Immune Activation and Mental Health
Funding Source:	NIH/NIDA
Role:	PI
ID:	R01 MH079829

Date:	2006 - 2011
Title:	Neuroinflammation and behavior in the aged
Funding Source:	NIH/NIA
Role:	Co-I
ID:	R01 AG016710

Date:	2005 - 2009
Title:	Neuroimmune control of biobehavioral processes
Funding Source:	NIH/NIA
Role:	Co-I
ID:	R01 AG023580

Date:	2004 - 2009
Title:	Cytokines, behavior and mental health
Funding Source:	NIH/NIMH
Role:	Co-I
ID:	R01 MH051569

Date:	2004 - 2009
Title:	Neuroimmunology of behavioral and mood disorders
Funding Source:	NIH/NIMH
Role:	PI
ID:	R01 MH071349

Date:	2004 - 2009
Title:	Brain Immune Interactions in Type 2 Diabetes Mellitus
Funding Source:	NIH/NIDDK
Role:	Co-I
ID:	R01 DK064862

Date:	2003 - 2008
Title:	Aging, Brain Cytokines and HIV-Associated Dementia
Funding Source:	NIH/NIMH
Role:	??
ID:	R01 MH069148

Date:	2001 - 2013
Title:	Training in Inflammation and Nutritional Dysfunction
Funding Source:	NIH/NIDDK
Role:	Co-I
ID:	T32 DK059802

Selected Publications

Peer-Reviewed Articles

Prossin AR, Holihan J, Cox CS Jr, Klein-Marcuschamer I, Aceves D, Minkowitz H, Dantzer R. IV IL-1 receptor antagonist reduces pain sensitivity and enhances brain endorphin release during a standardized, experimental, acute pain challenge: A BESH clinical trial. Brain Behav Immun:106165, 2025. e-Pub 2025. PMID: 41197684.
Komaki S, Imai R, Sugimoto Y, Settsu R, Obara A, Shimada A, Dantzer R, Laumet G, Imamura F, Hasegawa-Ishii S. Acute and chronic nasal inflammation induces lymphangiogenesis in the olfactory mucosa in mice. Brain Behav Immun Health 49:101119, 2025. e-Pub 2025. PMID: 41141867.
Inyang KE, Sim J, Clark KB, Geron M, Monahan K, Evans C, O'Connell P, Laumet S, Peng B, Ma J, Heijnen CJ, Dantzer R, Scherrer G, Kavelaars A, Bernard M, Aldhamen YA, Folger JK, Bavencoffe A, Laumet G. Upregulation of delta opioid receptor by meningeal interleukin-10 prevents relapsing pain. Brain Behav Immun 123:399-410, 2025. e-Pub 2025. PMID: 39349285.
Barr J, Walz A, Restaino AC, Amit M, Barclay SM, Vichaya EG, Spanos WC, Dantzer R, Talbot S, Vermeer PD. Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer. Elife 13, 2024. e-Pub 2024. PMID: 39302290.
Jimenez C, Habra MA, Campbell MT, Tamsen G, Cruz-Goldberg D, Long J, Bassett R, Dantzer R, Balderrama-Brondani V, Varghese J, Lu Y. Cabozantinib in patients with unresectable and progressive metastatic phaeochromocytoma or paraganglioma (the Natalie Trial): a single-arm, phase 2 trial. Lancet Oncol 25(5):658-667, 2024. e-Pub 2024. PMID: 38608693.
Falvey A, Palandira SP, Chavan SS, Brines M, Dantzer R, Tracey KJ, Pavlov VA. Electrical stimulation of the dorsal motor nucleus of the vagus in male mice can regulate inflammation without affecting the heart rate. Brain Behav Immun, 2024. e-Pub 2024. PMID: 38670240.
Amit M, Anastasaki C, Dantzer R, Demir IE, Deneen B, Dixon KO, Egeblad M, Gibson EM, Hervey-Jumper SL, Hondermarck H, Magnon C, Monje M, Na'ara S, Pan Y, Repasky EA, Scheff NN, Sloan EK, Talbot S, Tracey KJ, Trotman LC, Valiente M, Van Aelst L, Venkataramani V, Venkatesh HS, Vermeer PD, Winkler F, Wong RJ, Gutmann DH, Borniger JC. Next Directions in the Neuroscience of Cancers Arising outside the CNS. Cancer Discov 14(4):669-673, 2024. e-Pub 2024. PMID: 38571430.
Barr J, Walz A, Restaino AC, Amit M, Barclay SM, Vichaya EG, Spanos WC, Dantzer R, Talbot S, Vermeer PD. Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer. bioRxiv, 2024. e-Pub 2024. PMID: 37905135.
Phan TT, Scott KS, Chelette B, Phillip West A, Dantzer R. The fatigue-inducing effects of cancer and its therapy are characterized by decreased physical activity in the absence of any motivational deficit. Brain Behav Immun 117:205-214, 2024. e-Pub 2024. PMID: 38244945.
Chelette B, Bashaw A, Bryant JD, Abe L, Chidomere C, Scott K, West AP, Dantzer R. Activation of the cGAS-STING pathway contributes to cancer-related fatigue in a murine model of head and neck cancer. BioRxiv, 2023. e-Pub 2023.
Scott KS, Chelette B, Chidomere C, Phillip West A, Dantzer R. Cisplatin decreases voluntary wheel-running activity but does not impair food-motivated behavior in mice. Brain Behav Immun 111:169-176, 2023. e-Pub 2023. PMID: 37076053.
Abe JI, Imanishi M, Li S, Zhang A, Ko KA, Samanthapudi VSK, Lee LL, Bojorges AP, Gi YJ, Hobbs BP, Deswal A, Herrmann J, Lin SH, Chini EN, Shen YH, Schadler KL, Nguyen TH, Gupte AA, Reyes-Gibby C, Yeung SJ, Abe RJ, Olmsted-Davis EA, Krishnan S, Dantzer R, Palaskas NL, Cooke JP, Pownall HJ, Yoshimoto M, Fujiwara K, Hamilton DJ, Burks JK, Wang G, Le NT, Kotla S. An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis. Circ Res 133(1):25-44, 2023. e-Pub 2023. PMID: 37264926.
Inyang KE, Sim J, Clark KB, Matan G, Monahan K, Evans C, Beng P, Ma JV, Heijnen CJ, Dantzer R, Scherrer G, Kavelaars A, Bernard M, Aldhamen Y, Folger JK, Laumet G. Tonic Meningeal Interleukin-10 Upregulates Delta Opioid Receptor to Prevent Relapse to Pain. bioRxiv, 2023. e-Pub 2023. PMID: 37333074.
Scott K, Boukelmoune N, Taniguchi C, West AP, Heijnen CJ, Dantzer R. Resolution of cisplatin-induced fatigue does not require endogenous interleukin-10 in male mice. Behav Brain Res 444:114381, 2023. e-Pub 2023. PMID: 36870396.
Chelette B, Chidomere CL, Dantzer R. The GDF15-GFRAL axis mediates chemotherapy-induced fatigue in mice. Brain Behav Immun 108:45-54, 2023. e-Pub 2023. PMID: 36427806.
Scott K, Phan TT, Boukelmoune N, Heijnen CJ, Dantzer R. Chronic restraint stress impairs voluntary wheel running but has no effect on food-motivated behavior in mice. Brain Behav Immun 107:319-329, 2023. e-Pub 2023. PMID: 36349643.
Vichaya EG, Darpolor JK, Gross PS, Molkentine JM, Vermeer DW, Vermeer PD, Lee JH, Taniguchi CM, Dantzer R. Associative learning contributes to the persistence of fatigue-like behavior in male mice in a model of cancer survivorship. Brain Behav Immun 107:296-304, 2023. e-Pub 2023. PMID: 36323360.
Nguyen MTH, Imanishi M, Li S, Chau K, Banerjee P, Velatooru LR, Ko KA, Samanthapudi VSK, Gi YJ, Lee LL, Abe RJ, McBeath E, Deswal A, Lin SH, Palaskas NL, Dantzer R, Fujiwara K, Borchrdt MK, Turcios EB, Olmsted-Davis EA, Kotla S, Cooke JP, Wang G, Abe JI, Le NT. Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transition. Front Cardiovasc Med 10:1187490, 2023. e-Pub 2023. PMID: 37711550.
Asano H, Hasegawa-Ishii S, Arae K, Obara A, Laumet G, Dantzer R, Shimada A. Infiltration of peripheral immune cells into the olfactory bulb in a mouse model of acute nasal inflammation. J Neuroimmunol 368:577897, 2022. e-Pub 2022. PMID: 35661951.
Paul ER, Schwieler L, Erhardt S, Boda S, Trepci A, Kämpe R, Asratian A, Holm L, Yngve A, Dantzer R, Heilig M, Hamilton JP, Samuelsson M. Peripheral and central kynurenine pathway abnormalities in major depression. Brain Behav Immun 101:136-145, 2022. e-Pub 2022. PMID: 34999196.
Prossin A, Koch A, Campbell P, Laumet G, Stohler CS, Dantzer R, Zubieta JK. Effects of placebo administration on immune mechanisms and relationships with central endogenous opioid neurotransmission. Mol Psychiatry 27(2):831-839, 2022. e-Pub 2022. PMID: 34716408.
Vichaya EG, Ford BG, Moltenkine JM, Taniguchi CM, Phillip West A, Dantzer R. Sex differences in the behavioral and immune responses of mice to tumor growth and cancer therapy. Brain Behav Immun 98:161-172, 2021. e-Pub 2021. PMID: 34418499.
Chaskiel L, Dantzer R, Konsman JP. Brain Perivascular Macrophages Do Not Mediate Interleukin-1-Induced Sickness Behavior in Rats. Pharmaceuticals (Basel) 14(10), 2021. e-Pub 2021. PMID: 34681254.
Willette AA, Pappas C, Hoth N, Wang Q, Klinedinst B, Willette SA, Larsen B, Pollpeter A, Li T, Le S, Collazo-Martinez AD, Mochel JP, Allenspach K, Dantzer R, Neuroimaging Initiative AD. Inflammation, negative affect, and amyloid burden in Alzheimer's disease: Insights from the kynurenine pathway. Brain Behav Immun 95:216-225, 2021. e-Pub 2021. PMID: 33775832.
Dantzer R. Love and fear in the times of sickness. Compr Psychoneuroendocrinol 6, 2021. e-Pub 2021. PMID: 34327337.
Casaril AM, Vichaya EG, Rishi MR, Ford BG, Dantzer R. Lipopolysaccharide does not alter behavioral response to successive negative contrast in mice. Psychopharmacology (Berl) 238(3):691-697, 2021. e-Pub 2021. PMID: 33410982.
Scott K, Trong TP, West AP, Taniguchi CM, Dantzer R. Neutralizing interleukin-6 in tumor-bearing mice does not abrogate behavioral fatigue induced by Lewis lung carcinoma. Behav Brain Res 417, 2021. e-Pub 2021. PMID: 34571117.
Kappelmann N, Dantzer R, Khandaker GM. Interleukin-6 as potential mediator of long-term neuropsychiatric symptoms of COVID-19. Psychoneuroendocrinology 131, 2021. e-Pub 2021. PMID: 34119855.
Marim FM, Teixeira DC, Queiroz-Junior CM, Valiate BVS, Alves-Filho JC, Cunha TM, Dantzer R, Teixeira MM, Teixeira AL, Costa VV. Inhibition of Tryptophan Catabolism Is Associated With Neuroprotection During Zika Virus Infection. Front Immunol 12:702048, 2021. e-Pub 2021. PMID: 34335614.
Bryant JD, Kodali M, Shuai B, Menissy SS, Graves PJ, Trong Phan T, Dantzer R, Shetty AK, Ciaccia West L, West AP. Neuroimmune mechanisms of cognitive impairment in a mouse model of Gulf War illness. Brain Behav Immun 97:204-218, 2021. e-Pub 2021. PMID: 34333111.
Khandaker GM, Stochl J, Zammit S, Lewis G, Dantzer R, Jones PB. Association between circulating levels of C-reactive protein and positive and negative symptoms of psychosis in adolescents in a general population birth cohort. J Psychiatr Res 143:534-542, 2021. e-Pub 2021. PMID: 33229033.
Vichaya EG, Ford BG, Quave CB, Rishi MR, Grossberg AJ, Dantzer R. Toll-like receptor 4 mediates the development of fatigue in the murine Lewis Lung Carcinoma model independently of activation of macrophages and microglia. Psychoneuroendocrinology 122:104874, 2020. e-Pub 2020. PMID: 32979744.
Chirico M, Custer J, Shoyombo I, Cooper C, Meldrum S, Dantzer R, Trivedi MH, Rathouz P, Toups MS. Kynurenine pathway metabolites selectively associate with impaired associative memory function in depression. Brain Behav Immun Health 8:100126, 2020. e-Pub 2020. PMID: 34589879.
Laumet G, Bavencoffe A, Edralin JD, Huo XJ, Walters ET, Dantzer R, Heijnen CJ, Kavelaars A. Interleukin-10 resolves pain hypersensitivity induced by cisplatin by reversing sensory neuron hyperexcitability. Pain 161(10):2344-2352, 2020. e-Pub 2020. PMID: 32427749.
Grossberg AJ, Vichaya EG, Gross PS, Ford BG, Scott KA, Estrada D, Vermeer DW, Vermeer P, Dantzer R. Interleukin 6-independent metabolic reprogramming as a driver of cancer-related fatigue. Brain Behav Immun 88:230-241, 2020. e-Pub 2020. PMID: 32428555.
Vichaya EG, Malik S, Sominsky L, Ford BG, Spencer SJ, Dantzer R. Microglia depletion fails to abrogate inflammation-induced sickness in mice and rats. J Neuroinflammation 17(1):172, 2020. e-Pub 2020. PMID: 32475344.
Laumet G, Edralin JD, Dantzer R, Heijnen CJ, Kavelaars A. CD3+ T cells are critical for the resolution of comorbid inflammatory pain and depression-like behavior. Neurobiol Pain 7:100043, 2020. e-Pub 2020. PMID: 32510006.
Walker AK, Wing EE, Banks WA, Dantzer R. Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice. Mol Psychiatry 24(10):1523-1532, 2019. e-Pub 2019. PMID: 29988087.
Vichaya EG, Gross PS, Estrada DJ, Cole SW, Grossberg AJ, Evans SE, Tuvim MJ, Dickey BF, Dantzer R. Lipocalin-2 is dispensable in inflammation-induced sickness and depression-like behavior. Psychopharmacology (Berl) 236(10):2975-2982, 2019. e-Pub 2019. PMID: 30806746.
Chaskiel L, Bristow AD, Bluthé RM, Dantzer R, Blomqvist A, Konsman JP. Interleukin-1 reduces food intake and body weight in rat by acting in the arcuate hypothalamus. Brain Behav Immun 81:560-573, 2019. e-Pub 2019. PMID: 31310797.
Casaril AM, Domingues M, Bampi SR, de Andrade Lourenço D, Padilha NB, Lenardão EJ, Sonego M, Seixas FK, Collares T, Nogueira CW, Dantzer R, Savegnago L. The selenium-containing compound 3-((4-chlorophenyl)selanyl)-1-methyl-1H-indole reverses depressive-like behavior induced by acute restraint stress in mice: modulation of oxido-nitrosative stress and inflammatory pathway. Psychopharmacology (Berl) 236(10):2867-2880, 2019. e-Pub 2019. PMID: 30610349.
Dantzer R. Can Immunopsychiatry Help in Understanding the Basis of Sex Differences in Major Depressive Disorder?. Biol Psychiatry Cogn Neurosci Neuroimaging 4(7):606-607, 2019. e-Pub 2019. PMID: 31279402.
Laumet G, Edralin JD, Dantzer R, Heijnen CJ, Kavelaars A. Cisplatin educates CD8+ T cells to prevent and resolve chemotherapy-induced peripheral neuropathy in mice. Pain 160(6):1459-1468, 2019. e-Pub 2019. PMID: 30720585.
Dantzer R. From Stress Sensitization to Microglial Priming and Vice Versa: A New Era of Research in Biological Psychiatry. Biol Psychiatry 85(8):619-620, 2019. e-Pub 2019. PMID: 30922465.
Molkentine JM, Fujimoto TN, Horvath TD, Grossberg AJ, Garcia CJG, Deorukhkar A, de la Cruz Bonilla M, Lin D, Samuel ELG, Chan WK, Lorenzi PL, Piwnica-Worms H, Dantzer R, Tour JM, Mason KA, Taniguchi CM. Enteral Activation of WR-2721 Mediates Radioprotection and Improved Survival from Lethal Fractionated Radiation. Sci Rep 9(1):1949, 2019. e-Pub 2019. PMID: 30760738.
Vichaya EG, Laumet G, Christian DL, Grossberg AJ, Estrada DJ, Heijnen CJ, Kavelaars A, Dantzer R. Motivational changes that develop in a mouse model of inflammation-induced depression are independent of indoleamine 2,3 dioxygenase. Neuropsychopharmacology 44(2):364-371, 2019. e-Pub 2019. PMID: 29760410.
Vichaya EG, Vermeer DW, Budac D, Lee A, Grossberg A, Vermeer PD, Lee JH, Dantzer R. Inhibition of Indoleamine 2,3 Dioxygenase Does Not Improve Cancer-Related Symptoms in a Murine Model of Human Papilloma Virus-Related Head and Neck Cancer. Int J Tryptophan Res 12:1178646919872508, 2019. e-Pub 2019. PMID: 31496720.
Laumet G, Edralin JD, Chiang AC, Dantzer R, Heijnen CJ, Kavelaars A. Resolution of inflammation-induced depression requires T lymphocytes and endogenous brain interleukin-10 signaling. Neuropsychopharmacology 43(13):2597-2605, 2018. e-Pub 2018. PMID: 30054585.
Rodriguez-Zas SL, Wu C, Southey BR, O'Connor JC, Nixon SE, Garcia R, Zavala C, Lawson M, McCusker RH, Romanova EV, Sweedler JV, Kelley KW, Dantzer R. Disruption of microglia histone acetylation and protein pathways in mice exhibiting inflammation-associated depression-like symptoms. Psychoneuroendocrinology 97:47-58, 2018. e-Pub 2018. PMID: 30005281.
Madeo M, Colbert PL, Vermeer DW, Lucido CT, Cain JT, Vichaya EG, Grossberg AJ, Muirhead D, Rickel AP, Hong Z, Zhao J, Weimer JM, Spanos WC, Lee JH, Dantzer R, Vermeer PD. Cancer exosomes induce tumor innervation. Nat Commun 9(1):4284, 2018. e-Pub 2018. PMID: 30327461.
Lacourt TE, Vichaya EG, Escalante C, Manzullo EF, Gunn B, Hess KR, Heijnen CJ, Dantzer R. An effort expenditure perspective on cancer-related fatigue. Psychoneuroendocrinology 96:109-117, 2018. e-Pub 2018. PMID: 29929087.
Lacourt TE, De La Garza R, Dantzer R. Can cancer-related cognitive impairment be considered in isolation from other cancer-related symptoms?. Psychooncology 27(10):2511-2512, 2018. e-Pub 2018. PMID: 29956401.
Khandaker GM, Oltean BP, Kaser M, Dibben CRM, Ramana R, Jadon DR, Dantzer R, Coles AJ, Lewis G, Jones PB. Protocol for the insight study: a randomised controlled trial of single-dose tocilizumab in patients with depression and low-grade inflammation. BMJ Open 8(9):e025333, 2018. e-Pub 2018. PMID: 30244217.
Vichaya EG, Dantzer R. Inflammation-induced motivational changes: Perspective gained by evaluating positive and negative valence systems. Curr Opin Behav Sci 22:90-95, 2018. e-Pub 2018. PMID: 29888301.
Prossin AR, Chandler M, Ryan KA, Saunders EF, Kamali M, Papadopoulos V, Zöllner S, Dantzer R, McInnis MG. Functional TSPO polymorphism predicts variance in the diurnal cortisol rhythm in bipolar disorder. Psychoneuroendocrinology 89:194-202, 2018. e-Pub 2018. PMID: 29414032.
Grossberg AJ, Vichaya EG, Christian DL, Molkentine JM, Vermeer DW, Gross PS, Vermeer PD, Lee JH, Dantzer R. Tumor-associated fatigue in cancer patients develops independently of interleukin-1 signaling. Cancer Res 78(3):695-705, 2018. e-Pub 2018. PMID: 29217760.
Colpo GD, Leboyer M, Dantzer R, Trivedi MH, Teixeira AL. Immune-based strategies for mood disorders: facts and challenges. Expert Rev Neurother 18(2):1-14, 2018. e-Pub 2018. PMID: 29179585.
Kappelmann N, Lewis G, Dantzer R, Jones PB, Khandaker GM. Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions. Mol Psychiatry 23(2):335-343, 2018. e-Pub 2018. PMID: 27752078.
Dantzer R. Neuroimmune interactions: from the brain to the immune system and vice versa. Physiol Rev 98(1):477-504, 2018. e-Pub 2018. PMID: 29351513.
Meier TB, Drevets WC, Teague TK, Wurfel BE, Mueller SC, Bodurka J, Dantzer R, Savitz J. Kynurenic acid is reduced in females and oral contraceptive users: Implications for depression. Brain Behav Immun 67:59-64, 2018. e-Pub 2018. PMID: 28867283.
Laumet G, Zhou W, Dantzer R, Edralin JD, Huo X, Budac DP, O'Connor JC, Lee AW, Heijnen CJ, Kavelaars A. Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain. Brain Behav Immun 66:94-102, 2017. e-Pub 2017. PMID: 28709913.
Khandaker GM, Dantzer R, Jones PB. Immunopsychiatry: important facts. Psychol Med 47(13):1-9, 2017. e-Pub 2017. PMID: 28418288.
Cho HJ, Savitz J, Dantzer R, Teague TK, Drevets WC, Irwin MR. Sleep disturbance and kynurenine metabolism in depression. J Psychosom Res 99:1-7, 2017. e-Pub 2017. PMID: 28712413.
Wurfel BE, Drevets WC, Bliss SA, McMillin JR, Suzuki H, Ford BN, Morris HM, Teague TK, Dantzer R, Savitz JB. Serum kynurenic acid is reduced in affective psychosis. Transl Psychiatry 7(5):e1115, 2017. e-Pub 2017. PMID: 28463241.
Vichaya EG, Vermeer DW, Christian DL, Molkentine JM, Mason KA, Lee JH, Dantzer R. Neuroimmune mechanisms of behavioral alterations in a syngeneic murine model of human papilloma virus-related head and neck cancer. Psychoneuroendocrinology 79:59-66, 2017. e-Pub 2017. PMID: 28259044.
Lasselin J, Treadway MT, Lacourt TE, Soop A, Olsson MJ, Karshikoff B, Paues-Göranson S, Axelsson J, Dantzer R, Lekander M. Lipopolysaccharide alters motivated behavior in a monetary reward task: A randomized trial. Neuropsychopharmacology 42(4):801-810, 2017. e-Pub 2017. PMID: 27620550.
Chiu GS, Maj MA, Rizvi S, Dantzer R, Vichaya EG, Laumet G, Kavelaars A, Heijnen CJ. Pifithrin-µ prevents cisplatin-induced chemobrain by preserving neuronal mitochondrial function. Cancer Res 77(3):742-752, 2017. e-Pub 2017. PMID: 27879267.
Remus JL, Dantzer R. Inflammation models of depression in rodents: relevance to psychotropic drug discovery. Int J Neuropsychopharmacol 19(9), 2016. e-Pub 2016. PMID: 27026361.
Young KD, Drevets WC, Dantzer R, Teague TK, Bodurka J, Savitz J. Kynurenine pathway metabolites are associated with hippocampal activity during autobiographical memory recall in patients with depression. Brain Behav Immun 56:335-42, 2016. e-Pub 2016. PMID: 27091600.
Khandaker GM, Dantzer R. Is there a role for immune-to-brain communication in schizophrenia?. Psychopharmacology (Berl) 233(9):1559-73, 2016. e-Pub 2016. PMID: 26037944.
Meier TB, Drevets WC, Wurfel BE, Ford BN, Morris HM, Victor TA, Bodurka J, Teague TK, Dantzer R, Savitz J. Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder. Brain Behav Immun 53:39-48, 2016. e-Pub 2016. PMID: 26546831.
Vichaya EG, Molkentine JM, Vermeer DW, Walker AK, Feng R, Holder G, Luu K, Mason RM, Saligan L, Heijnen CJ, Kavelaars A, Mason KA, Lee JH, Dantzer R. Sickness behavior induced by cisplatin chemotherapy and radiotherapy in a murine head and neck cancer model is associated with altered mitochondrial gene expression. Behav Brain Res 297:241-250, 2016. e-Pub 2016. PMID: 26475509.
Gonzalez-Pena D, Nixon SE, O'Connor JC, Southey BR, Lawson MA, McCusker RH, Borras T, Machuca D, Hernandez AG, Dantzer R, Kelley KW, Rodriguez-Zas SL. Microglia transcriptome changes in a model of depressive behavior after immune challenge. PLoS One 11(3):e0150858, 2016. e-Pub 2016. PMID: 26959683.
LaVoy EC, Fagundes CP, Dantzer R. Exercise, inflammation, and fatigue in cancer survivors. Exerc Immunol Rev 22:82-93, 2016. e-Pub 2016. PMID: 26853557.
Gonzalez-Pena D, Nixon SE, Southey BR, Lawson MA, McCusker RH, Hernandez AG, Dantzer R, Kelley KW, Rodriguez-Zas SL. Differential transcriptome networks between IDO1-knockout and wild-type mice in brain microglia and macrophages. PLoS One 11(6):e0157727, 2016. e-Pub 2016. PMID: 27314674.
Savitz J, Dantzer R, Meier TB, Wurfel BE, Victor TA, McIntosh SA, Ford BN, Morris HM, Bodurka J, Teague TK, Drevets WC. Activation of the kynurenine pathway is associated with striatal volume in major depressive disorder. Psychoneuroendocrinology 62:54-8, 2015. e-Pub 2015. PMID: 26232650.
Zhou W, Dantzer R, Budac DP, Walker AK, Mao-Ying QL, Lee AW, Heijnen CJ, Kavelaars A. Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice. Brain Behav Immun 46:147-53, 2015. e-Pub 2015. PMID: 25637485.
Savitz J, Drevets WC, Wurfel BE, Ford BN, Bellgowan PS, Victor TA, Bodurka J, Teague TK, Dantzer R. Reduction of kynurenic acid to quinolinic acid ratio in both the depressed and remitted phases of major depressive disorder. Brain Behav Immun 46:55-9, 2015. e-Pub 2015. PMID: 25686798.
Nixon SE, González-Peña D, Lawson MA, McCusker RH, Hernandez AG, O'Connor JC, Dantzer R, Kelley KW, Rodriguez-Zas SL. Analytical workflow profiling gene expression in murine macrophages. J Bioinform Comput Biol 13(2):1550010, 2015. e-Pub 2015. PMID: 25708305.
Rodriguez-Zas SL, Nixon SE, Lawson MA, Mccusker RH, Southey BR, O'Connor JC, Dantzer R, Kelley KW. Advancing the understanding of behaviors associated with Bacille Calmette Guérin infection using multivariate analysis. Brain Behav Immun 44:176-86, 2015. e-Pub 2015. PMID: 25300921.
Savitz J, Dantzer R, Wurfel BE, Victor TA, Ford BN, Bodurka J, Bellgowan PS, Teague TK, Drevets WC. Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder. Psychoneuroendocrinology 52C:200-211, 2015. e-Pub 2015. PMID: 25486577.
Savitz J, Drevets WC, Smith CM, Victor TA, Wurfel BE, Bellgowan PS, Bodurka J, Teague TK, Dantzer R. Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorder. Neuropsychopharmacology 40(2):463-71, 2015. e-Pub 2015. PMID: 25074636.
Vichaya EG, Hunt SC, Dantzer R. Lipopolysaccharide reduces incentive motivation while boosting preference for high reward in mice. Neuropsychopharmacology 39(12):2884-90, 2014. e-Pub 2014. PMID: 24917202.
Dantzer R, Walker AK. Is there a role for glutamate-mediated excitotoxicity in inflammation-induced depression?. J Neural Transm (Vienna) 121(8):925-32, 2014. e-Pub 2014. PMID: 24633997.
Walker AK, Hsieh J, Luu KV, Radwan AA, Valverde GR, Dickey BF, Tuvim MJ, Dantzer R. Activation of lung toll-like receptors does not exacerbate sickness responses to lipopolysaccharide in mice. Brain Behav Immun 38:211-9, 2014. e-Pub 2014. PMID: 24534636.
Dantzer R, Heijnen CJ, Kavelaars A, Laye S, Capuron L. The neuroimmune basis of fatigue. Trends Neurosci 37(1):39-46, 2014. e-Pub 2014. PMID: 24239063.
Okusaga O, Muravitskaja O, Fuchs D, Ashraf A, Hinman S, Giegling I, Hartmann AM, Konte B, Friedl M, Schiffman J, Hong E, Reeves G, Groer M, Dantzer R, Rujescu D, Postolache TT. Elevated levels of plasma phenylalanine in schizophrenia: a guanosine triphosphate cyclohydrolase-1 metabolic pathway abnormality?. PLoS One 9(1):e85945, 2014. e-Pub 2014. PMID: 24465804.
Alfaro VY, Goldblatt DL, Valverde GR, Munsell MF, Quinton LJ, Walker AK, Dantzer R, Varadhachary A, Scott BL, Evans SE, Tuvim MJ, Dickey BF. Safety, tolerability, and biomarkers of the treatment of mice with aerosolized toll-like receptor ligands. Front Pharmacol 5:8, 2014. e-Pub 2014. PMID: 24567720.
Walker AK, Kavelaars A, Heijnen CJ, Dantzer R. Neuroinflammation and comorbidity of pain and depression. Pharmacol Rev 66(1):80-101, 2014. e-Pub 2014. PMID: 24335193.
Martin SA, Dantzer R, Kelley KW, Woods JA. Voluntary wheel running does not affect lipopolysaccharide-induced depressive-like behavior in young adult and aged mice. Neuroimmunomodulation 21(1):52-63, 2014. e-Pub 2014. PMID: 24281669.
Walker AK, Budac DP, Bisulco S, Lee AW, Smith RA, Beenders B, Kelley KW, Dantzer R. NMDA receptor blockade by ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL/6J mice. Neuropsychopharmacology 38(9):1609-16, 2013. e-Pub 2013. PMID: 23511700.
Kelley KW, O'Connor JC, Lawson MA, Dantzer R, Rodriguez-Zas SL, McCusker RH. Aging leads to prolonged duration of inflammation-induced depression-like behavior caused by Bacillus Calmette-Guérin. Brain Behav Immun 32:63-9, 2013. e-Pub 2013. PMID: 23454036.
Corona AW, Norden DM, Skendelas JP, Huang Y, O'Connor JC, Lawson M, Dantzer R, Kelley KW, Godbout JP. Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX(3)CR1)-deficient mice. Brain Behav Immun 31:134-42, 2013. e-Pub 2013. PMID: 22926082.
Martin SA, Pence BD, Greene RM, Johnson SJ, Dantzer R, Kelley KW, Woods JA. Effects of voluntary wheel running on LPS-induced sickness behavior in aged mice. Brain Behav Immun 29:113-23, 2013. e-Pub 2013. PMID: 23277090.
Lawson MA, Parrott JM, McCusker RH, Dantzer R, Kelley KW, O Connor JC. Intracerebroventricular administration of lipopolysaccharide induces indoleamine-2,3-dioxygenase-dependent depression-like behaviors. J Neuroinflammation 10(1):87, 2013. e-Pub 2013. PMID: 23866724.
Dantzer R, Meagher MW, Cleeland CS. Translational approaches to treatment-induced symptoms in cancer patients. Nat Rev Clin Oncol 9(7):414-26, 2012. e-Pub 2012. PMID: 22641361.
Park MJ, Yoo SW, Choe BS, Dantzer R, Freund GG. Acute hypoglycemia causes depressive-like behaviors in mice. Metabolism 61(2):229-36, 2012. e-Pub 2012. PMID: 21820138.
Eijkelkamp N, Heijnen CJ, Carbajal AG, Willemen HL, Wang H, Minett MS, Wood JN, Schedlowski M, Dantzer R, Kelley KW, Kavelaars A. GRK6 acts as a critical regulator of cytokine-induced hyperalgesia by promoting PI3kinase- and inhibiting p38-signaling. Mol Med 18(1):556-64, 2012. e-Pub 2012. PMID: 22331028.
Lawson MA, Kelley KW, Dantzer R. Intracerebroventricular administration of HIV-1 Tat induces brain cytokine and indoleamine 2,3-dioxygenase expression: a possible mechanism for AIDS comorbid depression. Brain Behav Immun 25(8):1569-75, 2011. e-Pub 2011. PMID: 21620953.
Valentine RJ, Woods JA, McAuley E, Dantzer R, Evans EM. The associations of adiposity, physical activity and inflammation with fatigue in older adults. Brain Behav Immun 25(7):1482-90, 2011. e-Pub 2011. PMID: 21693185.
Wang H, Heijnen CJ, Eijkelkamp N, Garza Carbajal A, Schedlowski M, Kelley KW, Dantzer R, Kavelaars A. GRK2 in sensory neurons regulates epinephrine-induced signalling and duration of mechanical hyperalgesia. Pain 152(7):1649-58, 2011. e-Pub 2011. PMID: 21514055.
Kohman RA, Rodriguez-Zas SL, Southey BR, Kelley KW, Dantzer R, Rhodes JS. Voluntary wheel running reverses age-induced changes in hippocampal gene expression. PLoS One 6(8):e22654, 2011. e-Pub 2011. PMID: 21857943.
Park SE, Lawson M, Dantzer R, Kelley KW, McCusker RH. Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharide. J Neuroinflammation 8:179, 2011. e-Pub 2011. PMID: 22189158.
Fu X, Lawson MA, Kelley KW, Dantzer R. HIV-1 Tat activates indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures in a p38 mitogen-activated protein kinase-dependent manner. J Neuroinflammation 8:88, 2011. e-Pub 2011. PMID: 21810259.
Park SE, Dantzer R, Kelley KW, McCusker RH. Central administration of insulin-like growth factor-I decreases depressive-like behavior and brain cytokine expression in mice. J Neuroinflammation 8:12, 2011. e-Pub 2011. PMID: 21306618.
Wang Y, Lawson MA, Kelley KW, Dantzer R. Primary murine microglia are resistant to nitric oxide inhibition of indoleamine 2,3-dioxygenase. Brain Behav Immun 24(8):1249-53, 2010. e-Pub 2010. PMID: 20451602.
Luo L, Rodriguez E, Jerbi K, Lachaux JP, Martinerie J, Corbetta M, Shulman GL, Piomelli D, Turrigiano GG, Nelson SB, Joëls M, de Kloet ER, Holsboer F, Amodio DM, Frith CD, Block ML, Zecca L, Hong JS, Dantzer R, Kelley KW, Craig AD. Ten years of Nature Reviews Neuroscience: insights from the highly cited. Nat Rev Neurosci 11(10):718-26, 2010. e-Pub 2010. PMID: 20852655.
Eijkelkamp N, Wang H, Garza-Carbajal A, Willemen HL, Zwartkruis FJ, Wood JN, Dantzer R, Kelley KW, Heijnen CJ, Kavelaars A. Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK. J Neurosci 30(38):12806-15, 2010. e-Pub 2010. PMID: 20861385.
Willemen HL, Eijkelkamp N, Wang H, Dantzer R, Dorn GW, Kelley KW, Heijnen CJ, Kavelaars A. Microglial/macrophage GRK2 determines duration of peripheral IL-1beta-induced hyperalgesia: contribution of spinal cord CX3CR1, p38 and IL-1 signaling. Pain 150(3):550-60, 2010. e-Pub 2010. PMID: 20609517.
Raison CL, Dantzer R, Kelley KW, Lawson MA, Woolwine BJ, Vogt G, Spivey JR, Saito K, Miller AH. CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression. Mol Psychiatry 15(4):393-403, 2010. e-Pub 2010. PMID: 19918244.
Wang Y, Lawson MA, Dantzer R, Kelley KW. LPS-induced indoleamine 2,3-dioxygenase is regulated in an interferon-gamma-independent manner by a JNK signaling pathway in primary murine microglia. Brain Behav Immun 24(2):201-9, 2010. e-Pub 2010. PMID: 19577630.
Corona AW, Huang Y, O'Connor JC, Dantzer R, Kelley KW, Popovich PG, Godbout JP. Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide. J Neuroinflammation 7:93, 2010. e-Pub 2010. PMID: 21167054.
Fu X, Zunich SM, O'Connor JC, Kavelaars A, Dantzer R, Kelley KW. Central administration of lipopolysaccharide induces depressive-like behavior in vivo and activates brain indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures. J Neuroinflammation 7:43, 2010. e-Pub 2010. PMID: 20678226.
Dantzer R. Cytokine, sickness behavior, and depression. Immunol Allergy Clin North Am 29(2):247-64, 2009. e-Pub 2009. PMID: 19389580.
O'Connor JC, Lawson MA, André C, Moreau M, Lestage J, Castanon N, Kelley KW, Dantzer R. Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice. Mol Psychiatry 14(5):511-22, 2009. e-Pub 2009. PMID: 18195714.
O'Connor JC, André C, Wang Y, Lawson MA, Szegedi SS, Lestage J, Castanon N, Kelley KW, Dantzer R. Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin. J Neurosci 29(13):4200-9, 2009. e-Pub 2009. PMID: 19339614.
O'Connor JC, Lawson MA, André C, Briley EM, Szegedi SS, Lestage J, Castanon N, Herkenham M, Dantzer R, Kelley KW. Induction of IDO by bacille Calmette-Guérin is responsible for development of murine depressive-like behavior. J Immunol 182(5):3202-12, 2009. e-Pub 2009. PMID: 19234218.
Palin K, Bluthé RM, McCusker RH, Levade T, Moos F, Dantzer R, Kelley KW. The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behavior. Psychopharmacology (Berl) 201(4):549-56, 2009. e-Pub 2009. PMID: 18825372.
Dantzer R, Kalin N. Salivary biomarkers of stress: cortisol and alpha-amylase. Psychoneuroendocrinology 34(1):1, 2009. e-Pub 2009. PMID: 19059730.
Konsman JP, Veeneman J, Combe C, Poole S, Luheshi GN, Dantzer R. Central nervous action of interleukin-1 mediates activation of limbic structures and behavioural depression in response to peripheral administration of bacterial lipopolysaccharide. Eur J Neurosci 28(12):2499-510, 2008. e-Pub 2008. PMID: 19087175.
Huang Y, Henry CJ, Dantzer R, Johnson RW, Godbout JP. Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide. Neurobiol Aging 29(11):1744-53, 2008. e-Pub 2008. PMID: 17543422.
Mingam R, Moranis A, Bluthé RM, De Smedt-Peyrusse V, Kelley KW, Guesnet P, Lavialle M, Dantzer R, Layé S. Uncoupling of interleukin-6 from its signalling pathway by dietary n-3-polyunsaturated fatty acid deprivation alters sickness behaviour in mice. Eur J Neurosci 28(9):1877-86, 2008. e-Pub 2008. PMID: 18973601.
Moreau M, André C, O'Connor JC, Dumich SA, Woods JA, Kelley KW, Dantzer R, Lestage J, Castanon N. Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior. Brain Behav Immun 22(7):1087-95, 2008. e-Pub 2008. PMID: 18479887.
Godbout JP, Moreau M, Lestage J, Chen J, Sparkman NL, O' Connor J, Castanon N, Kelley KW, Dantzer R, Johnson RW. Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system. Neuropsychopharmacology 33(10):2341-51, 2008. e-Pub 2008. PMID: 18075491.
André C, O'Connor JC, Kelley KW, Lestage J, Dantzer R, Castanon N. Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration. J Neuroimmunol 200(1-2):90-9, 2008. e-Pub 2008. PMID: 18653240.
Dantzer R, Kelley KW. Autistic children: a neuroimmune perspective. Brain Behav Immun 22(6):804-5, 2008. e-Pub 2008. PMID: 18420377.
Palin K, McCusker RH, Strle K, Moos F, Dantzer R, Kelley KW. Tumor necrosis factor-alpha-induced sickness behavior is impaired by central administration of an inhibitor of c-jun N-terminal kinase. Psychopharmacology (Berl) 197(4):629-35, 2008. e-Pub 2008. PMID: 18274729.
Abraham J, Jang S, Godbout JP, Chen J, Kelley KW, Dantzer R, Johnson RW. Aging sensitizes mice to behavioral deficits induced by central HIV-1 gp120. Neurobiol Aging 29(4):614-21, 2008. e-Pub 2008. PMID: 17174449.
Strle K, McCusker RH, Johnson RW, Zunich SM, Dantzer R, Kelley KW. Prototypical anti-inflammatory cytokine IL-10 prevents loss of IGF-I-induced myogenin protein expression caused by IL-1beta. Am J Physiol Endocrinol Metab 294(4):E709-18, 2008. e-Pub 2008. PMID: 18270299.
Mingam R, De Smedt V, Amédée T, Bluthé RM, Kelley KW, Dantzer R, Layé S. In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1 beta in the murine brain. Brain Behav Immun 22(2):234-44, 2008. e-Pub 2008. PMID: 17905568.
Dantzer R, Capuron L, Irwin MR, Miller AH, Ollat H, Perry VH, Rousey S, Yirmiya R. Identification and treatment of symptoms associated with inflammation in medically ill patients. Psychoneuroendocrinology 33(1):18-29, 2008. e-Pub 2008. PMID: 18061362.
Strle K, McCusker RH, Tran L, King A, Johnson RW, Freund GG, Dantzer R, Kelley KW. Novel activity of an anti-inflammatory cytokine: IL-10 prevents TNFalpha-induced resistance to IGF-I in myoblasts. J Neuroimmunol 188(1-2):48-55, 2007. e-Pub 2007. PMID: 17572510.
Palin K, Bluthé RM, McCusker RH, Moos F, Dantzer R, Kelley KW. TNFalpha-induced sickness behavior in mice with functional 55 kD TNF receptors is blocked by central IGF-I. J Neuroimmunol 187(1-2):55-60, 2007. e-Pub 2007. PMID: 17512609.
Frenois F, Moreau M, O'Connor J, Lawson M, Micon C, Lestage J, Kelley KW, Dantzer R, Castanon N. Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior. Psychoneuroendocrinology 32(5):516-31, 2007. e-Pub 2007. PMID: 17482371.
Benchenane K, Castel H, Boulouard M, Bluthé R, Fernandez-Monreal M, Roussel BD, Lopez-Atalaya JP, Butt-Gueulle S, Agin V, Maubert E, Dantzer R, Touzani O, Dauphin F, Vivien D, Ali C. Anti-NR1 N-terminal-domain vaccination unmasks the crucial action of tPA on NMDA-receptor-mediated toxicity and spatial memory. J Cell Sci 120(Pt 4):578-85, 2007. e-Pub 2007. PMID: 17244650.
Dantzer R, Kelley KW. Twenty years of research on cytokine-induced sickness behavior. Brain Behav Immun 21(2):153-60, 2007. e-Pub 2007. PMID: 17088043.
McCusker RH, McCrea K, Zunich S, Dantzer R, Broussard SR, Johnson RW, Kelley KW. Insulin-like growth factor-I enhances the biological activity of brain-derived neurotrophic factor on cerebrocortical neurons. J Neuroimmunol 179(1-2):186-90, 2006. e-Pub 2006. PMID: 16890297.
Strle K, Broussard SR, McCusker RH, Shen WH, LeCleir JM, Johnson RW, Freund GG, Dantzer R, Kelley KW. C-jun N-terminal kinase mediates tumor necrosis factor-alpha suppression of differentiation in myoblasts. Endocrinology 147(9):4363-73, 2006. e-Pub 2006. PMID: 16777978.
Kappeler L, Gautron L, Layé S, Dantzer R, Zizzari P, Epelbaum J, Bluet-Pajot MT. Pituitary cocaine- and amphetamine-regulated transcript expression depends on the strain, sex and oestrous cycle in the rat. J Neuroendocrinol 18(6):426-33, 2006. e-Pub 2006. PMID: 16684132.
Bluthé RM, Kelley KW, Dantzer R. Effects of insulin-like growth factor-I on cytokine-induced sickness behavior in mice. Brain Behav Immun 20(1):57-63, 2006. e-Pub 2006. PMID: 16364817.
Bluthé RM, Frenois F, Kelley KW, Dantzer R. Pentoxifylline and insulin-like growth factor-I (IGF-I) abrogate kainic acid-induced cognitive impairment in mice. J Neuroimmunol 169(1-2):50-8, 2005. e-Pub 2005. PMID: 16154639.
Johnson DR, O'Connor JC, Dantzer R, Freund GG. Inhibition of vagally mediated immune-to-brain signaling by vanadyl sulfate speeds recovery from sickness. Proc Natl Acad Sci U S A 102(42):15184-9, 2005. e-Pub 2005. PMID: 16217019.
Hébert G, Mingam R, Arsaut J, Dantzer R, Demotes-Mainard J. Cellular distribution of interleukin-1alpha-immunoreactivity after MPTP intoxication in mice. Brain Res Mol Brain Res 138(2):156-63, 2005. e-Pub 2005. PMID: 15922486.
Moreau M, Lestage J, Verrier D, Mormede C, Kelley KW, Dantzer R, Castanon N. Bacille Calmette-Guérin inoculation induces chronic activation of peripheral and brain indoleamine 2,3-dioxygenase in mice. J Infect Dis 192(3):537-44, 2005. e-Pub 2005. PMID: 15995970.
Nadjar A, Tridon V, May MJ, Ghosh S, Dantzer R, Amédée T, Parnet P. NFkappaB activates in vivo the synthesis of inducible Cox-2 in the brain. J Cereb Blood Flow Metab 25(8):1047-59, 2005. e-Pub 2005. PMID: 15758944.
Constant A, Castera L, Dantzer R, Couzigou P, de Ledinghen V, Demotes-Mainard J, Henry C. Mood alterations during interferon-alfa therapy in patients with chronic hepatitis C: evidence for an overlap between manic/hypomanic and depressive symptoms. J Clin Psychiatry 66(8):1050-7, 2005. e-Pub 2005. PMID: 16086622.
Nadjar A, Bluthé RM, May MJ, Dantzer R, Parnet P. Inactivation of the cerebral NFkappaB pathway inhibits interleukin-1beta-induced sickness behavior and c-Fos expression in various brain nuclei. Neuropsychopharmacology 30(8):1492-9, 2005. e-Pub 2005. PMID: 15900319.
Hébert G, Mingam R, Arsaut J, Dantzer R, Demotes-Mainard J. A role of IL-1 in MPTP-induced changes in striatal dopaminergic and serotoninergic transporter binding: clues from interleukin-1 type I receptor-deficient mice. Brain Res Mol Brain Res 136(1-2):267-70, 2005. e-Pub 2005. PMID: 15893609.
O'Connor JC, Satpathy A, Hartman ME, Horvath EM, Kelley KW, Dantzer R, Johnson RW, Freund GG. IL-1beta-mediated innate immunity is amplified in the db/db mouse model of type 2 diabetes. J Immunol 174(8):4991-7, 2005. e-Pub 2005. PMID: 15814729.
Aubert A, Dantzer R. The taste of sickness: lipopolysaccharide-induced finickiness in rats. Physiol Behav 84(3):437-44, 2005. e-Pub 2005. PMID: 15763581.
Nadjar A, Combe C, Busquet P, Dantzer R, Parnet P. Signaling pathways of interleukin-1 actions in the brain: anatomical distribution of phospho-ERK1/2 in the brain of rat treated systemically with interleukin-1beta. Neuroscience 134(3):921-32, 2005. e-Pub 2005. PMID: 16039791.
Strle K, Broussard SR, McCusker RH, Shen WH, Johnson RW, Freund GG, Dantzer R, Kelley KW. Proinflammatory cytokine impairment of insulin-like growth factor I-induced protein synthesis in skeletal muscle myoblasts requires ceramide. Endocrinology 145(10):4592-602, 2004. e-Pub 2004. PMID: 15256490.
Merlot E, Moze E, Bartolomucci A, Dantzer R, Neveu PJ. The rank assessed in a food competition test influences subsequent reactivity to immune and social challenges in mice. Brain Behav Immun 18(5):468-75, 2004. e-Pub 2004. PMID: 15265540.
Porcher J, Cousson-Gélie F, Dantzer R. Affective components of the human-animal relationship in animal husbandry: development and validation of a questionnaire. Psychol Rep 95(1):275-90, 2004. e-Pub 2004. PMID: 15460383.
Castanon N, Médina C, Mormède C, Dantzer R. Chronic administration of tianeptine balances lipopolysaccharide-induced expression of cytokines in the spleen and hypothalamus of rats. Psychoneuroendocrinology 29(6):778-90, 2004. e-Pub 2004. PMID: 15110927.
Shen WH, Zhou JH, Broussard SR, Johnson RW, Dantzer R, Kelley KW. Tumor necrosis factor alpha inhibits insulin-like growth factor I-induced hematopoietic cell survival and proliferation. Endocrinology 145(7):3101-5, 2004. e-Pub 2004. PMID: 15087433.
Broussard SR, McCusker RH, Novakofski JE, Strle K, Shen WH, Johnson RW, Dantzer R, Kelley KW. IL-1beta impairs insulin-like growth factor i-induced differentiation and downstream activation signals of the insulin-like growth factor i receptor in myoblasts. J Immunol 172(12):7713-20, 2004. e-Pub 2004. PMID: 15187154.
Shen WH, Jackson ST, Broussard SR, McCusker RH, Strle K, Freund GG, Johnson RW, Dantzer R, Kelley KW. IL-1beta suppresses prolonged Akt activation and expression of E2F-1 and cyclin A in breast cancer cells. J Immunol 172(12):7272-81, 2004. e-Pub 2004. PMID: 15187102.
Palin K, Bluthé RM, Verrier D, Tridon V, Dantzer R, Lestage J. Interleukin-1beta mediates the memory impairment associated with a delayed type hypersensitivity response to bacillus Calmette-Guérin in the rat hippocampus. Brain Behav Immun 18(3):223-30, 2004. e-Pub 2004. PMID: 15050649.
Capuron L, Ravaud A, Miller AH, Dantzer R. Baseline mood and psychosocial characteristics of patients developing depressive symptoms during interleukin-2 and/or interferon-alpha cancer therapy. Brain Behav Immun 18(3):205-13, 2004. e-Pub 2004. PMID: 15050647.
Palin K, Verrier D, Tridon V, Hurst J, Perry VH, Dantzer R, Lestage J. Influence of the course of brain inflammation on the endogenous IL-1beta/IL-1Ra balance in the model of brain delayed-type hypersensitivity response to bacillus Calmette-Guérin in Lewis rats. J Neuroimmunol 149(1-2):22-30, 2004. e-Pub 2004. PMID: 15020061.
Mormède C, Palin K, Kelley KW, Castanon N, Dantzer R. Conditioned taste aversion with lipopolysaccharide and peptidoglycan does not activate cytokine gene expression in the spleen and hypothalamus of mice. Brain Behav Immun 18(2):186-200, 2004. e-Pub 2004. PMID: 14759596.
Merlot E, Moze E, Dantzer R, Neveu PJ. Cytokine production by spleen cells after social defeat in mice: activation of T cells and reduced inhibition by glucocorticoids. Stress 7(1):55-61, 2004. e-Pub 2004. PMID: 15204033.
Shen WH, Yin Y, Broussard SR, McCusker RH, Freund GG, Dantzer R, Kelley KW. Tumor necrosis factor alpha inhibits cyclin A expression and retinoblastoma hyperphosphorylation triggered by insulin-like growth factor-I induction of new E2F-1 synthesis. J Biol Chem 279(9):7438-46, 2004. e-Pub 2004. PMID: 14681231.
Dantzer R. Innate immunity at the forefront of psychoneuroimmunology. Brain Behav Immun 18(1):1-6, 2004. e-Pub 2004. PMID: 14651940.
Merlot E, Moze E, Dantzer R, Neveu PJ. Immune alterations induced by social defeat do not alter the course of an on-going BCG infection in mice. Neuroimmunomodulation 11(6):414-8, 2004. e-Pub 2004. PMID: 15467357.
Bartolomucci A, Palanza P, Parmigiani S, Pederzani T, Merlot E, Neveu PJ, Dantzer R. Chronic psychosocial stress down-regulates central cytokines mRNA. Brain Res Bull 62(3):173-8, 2003. e-Pub 2003. PMID: 14698350.
Merlot E, Moze E, Dantzer R, Neveu PJ. Importance of fighting in the immune effects of social defeat. Physiol Behav 80(2-3):351-7, 2003. e-Pub 2003. PMID: 14637235.
Nadjar A, Combe C, Layé S, Tridon V, Dantzer R, Amédée T, Parnet P. Nuclear factor kappaB nuclear translocation as a crucial marker of brain response to interleukin-1. A study in rat and interleukin-1 type I deficient mouse. J Neurochem 87(4):1024-36, 2003. e-Pub 2003. PMID: 14622131.
Hébert G, Arsaut J, Dantzer R, Demotes-Mainard J. Time-course of the expression of inflammatory cytokines and matrix metalloproteinases in the striatum and mesencephalon of mice injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a dopaminergic neurotoxin. Neurosci Lett 349(3):191-5, 2003. e-Pub 2003. PMID: 12951201.
Broussard SR, McCusker RH, Novakofski JE, Strle K, Shen WH, Johnson RW, Freund GG, Dantzer R, Kelley KW. Cytokine-hormone interactions: tumor necrosis factor alpha impairs biologic activity and downstream activation signals of the insulin-like growth factor I receptor in myoblasts. Endocrinology 144(7):2988-96, 2003. e-Pub 2003. PMID: 12810554.
Cleeland CS, Bennett GJ, Dantzer R, Dougherty PM, Dunn AJ, Meyers CA, Miller AH, Payne R, Reuben JM, Wang XS, Lee BN. Are the symptoms of cancer and cancer treatment due to a shared biologic mechanism? A cytokine-immunologic model of cancer symptoms. Cancer 97(11):2919-25, 2003. e-Pub 2003. PMID: 12767108.
Mormède C, Castanon N, Médina C, Dantzer R. Conditioned place aversion with interleukin-1beta in mice is not associated with activation of the cytokine network. Brain Behav Immun 17(2):110-20, 2003. e-Pub 2003. PMID: 12676573.
Burgess W, Jesse K, Tang Q, Broussard SR, Dantzer R, Kelley KW. Insulin-like growth factor-I and the cytokines IL-3 and IL-4 promote survival of progenitor myeloid cells by different mechanisms. J Neuroimmunol 135(1-2):82-90, 2003. e-Pub 2003. PMID: 12576227.
Castanon N, Konsman JP, Médina C, Chauvet N, Dantzer R. Chronic treatment with the antidepressant tianeptine attenuates lipopolysaccharide-induced Fos expression in the rat paraventricular nucleus and HPA axis activation. Psychoneuroendocrinology 28(1):19-34, 2003. e-Pub 2003. PMID: 12445834.
Dantzer R. Is it important to know about emotions in order to study emotions?. Behav Processes 60(2):V-VII, 2002. e-Pub 2002. PMID: 12426070.
Lestage J, Verrier D, Palin K, Dantzer R. The enzyme indoleamine 2,3-dioxygenase is induced in the mouse brain in response to peripheral administration of lipopolysaccharide and superantigen. Brain Behav Immun 16(5):596-601, 2002. e-Pub 2002. PMID: 12401474.
Dantzer R, Wollman EE, Yirmiya R. Cytokines and depression: an update. Brain Behav Immun 16(5):501-2, 2002. e-Pub 2002. PMID: 12401463.
Shen WH, Zhou JH, Broussard SR, Freund GG, Dantzer R, Kelley KW. Proinflammatory cytokines block growth of breast cancer cells by impairing signals from a growth factor receptor. Cancer Res 62(16):4746-56, 2002. e-Pub 2002. PMID: 12183434.
Véga C, Pellerin L, Dantzer R, Magistretti PJ. Long-term modulation of glucose utilization by IL-1 alpha and TNF-alpha in astrocytes: Na+ pump activity as a potential target via distinct signaling mechanisms. Glia 39(1):10-8, 2002. e-Pub 2002. PMID: 12112371.
Merlot E, Moze E, Dantzer R, Neveu PJ. Suppression of restraint-induced plasma cytokines in mice pretreated with LPS. Stress 5(2):131-5, 2002. e-Pub 2002. PMID: 12186691.
French RA, Broussard SR, Meier WA, Minshall C, Arkins S, Zachary JF, Dantzer R, Kelley KW. Age-associated loss of bone marrow hematopoietic cells is reversed by GH and accompanies thymic reconstitution. Endocrinology 143(2):690-9, 2002. e-Pub 2002. PMID: 11796526.
Strle K, Zhou JH, Broussard SR, Venters HD, Johnson RW, Freund GG, Dantzer R, Kelley KW. IL-10 promotes survival of microglia without activating Akt. J Neuroimmunol 122(1-2):9-19, 2002. e-Pub 2002. PMID: 11777539.
Bluthé RM, Lestage J, Rees G, Bristow A, Dantzer R. Dual effect of central injection of recombinant rat interleukin-4 on lipopolysaccharide-induced sickness behavior in rats. Neuropsychopharmacology 26(1):86-93, 2002. e-Pub 2002. PMID: 11751035.
Capuron L, Ravaud A, Neveu PJ, Miller AH, Maes M, Dantzer R. Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy. Mol Psychiatry 7(5):468-73, 2002. e-Pub 2002. PMID: 12082564.
Mormède C, Castanon N, Médina C, Moze E, Lestage J, Neveu PJ, Dantzer R. Chronic mild stress in mice decreases peripheral cytokine and increases central cytokine expression independently of IL-10 regulation of the cytokine network. Neuroimmunomodulation 10(6):359-66, 2002. e-Pub 2002. PMID: 12907843.
Bluthé RM, Bristow A, Lestage J, Imbs C, Dantzer R. Central injection of interleukin-13 potentiates LPS-induced sickness behavior in rats. Neuroreport 12(18):3979-83, 2001. e-Pub 2001. PMID: 11742223.
Pousset F, Cremona S, Dantzer R, Kelley KW, Parnet P. IL-10 and IL-4 regulate type-I and type-II IL-1 receptors expression on IL-1 beta-activated mouse primary astrocytes. J Neurochem 79(4):726-36, 2001. e-Pub 2001. PMID: 11723165.
Capuron L, Ravaud A, Gualde N, Bosmans E, Dantzer R, Maes M, Neveu PJ. Association between immune activation and early depressive symptoms in cancer patients treated with interleukin-2-based therapy. Psychoneuroendocrinology 26(8):797-808, 2001. e-Pub 2001. PMID: 11585680.
Zhou JH, Broussard SR, Strle K, Freund GG, Johnson RW, Dantzer R, Kelley KW. IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and phosphatidylinositol 3'-kinase. J Immunol 167(8):4436-42, 2001. e-Pub 2001. PMID: 11591769.
Zubareva OE, Krasnova IN, Abdurasulova IN, Bluthe RM, Dantzer R, Klimenko VM. Effects of serotonin synthesis blockade on interleukin-1 beta action in the brain of rats. Brain Res 915(2):244-7, 2001. e-Pub 2001. PMID: 11595215.
Chauvet N, Palin K, Verrier D, Poole S, Dantzer R, Lestage J. Rat microglial cells secrete predominantly the precursor of interleukin-1beta in response to lipopolysaccharide. Eur J Neurosci 14(4):609-17, 2001. e-Pub 2001. PMID: 11556886.
Capuron L, Bluthé RM, Dantzer R. Cytokines in clinical psychiatry. Am J Psychiatry 158(7):1163-4, 2001. e-Pub 2001. PMID: 11431252.
Capuron L, Ravaud A, Dantzer R. Timing and specificity of the cognitive changes induced by interleukin-2 and interferon-alpha treatments in cancer patients. Psychosom Med 63(3):376-86, 2001. e-Pub 2001. PMID: 11382265.
Castanon N, Bluthé RM, Dantzer R. Chronic treatment with the atypical antidepressant tianeptine attenuates sickness behavior induced by peripheral but not central lipopolysaccharide and interleukin-1beta in the rat. Psychopharmacology (Berl) 154(1):50-60, 2001. e-Pub 2001. PMID: 11292006.
Pousset F, Cremona S, Dantzer R, Kelley KW, Parnet P. Dexamethasone up-regulates type II IL-1 receptor in mouse primary activated astrocytes. J Neurochem 76(3):901-9, 2001. e-Pub 2001. PMID: 11158262.
Maes M, Capuron L, Ravaud A, Gualde N, Bosmans E, Egyed B, Dantzer R, Neveu PJ. Lowered serum dipeptidyl peptidase IV activity is associated with depressive symptoms and cytokine production in cancer patients receiving interleukin-2-based immunotherapy. Neuropsychopharmacology 24(2):130-40, 2001. e-Pub 2001. PMID: 11120395.
Palin K, Pousset F, Verrier D, Dantzer R, Kelley K, Parnet P, Lestage J. Characterization of interleukin-1 receptor antagonist isoform expression in the brain of lipopolysaccharide-treated rats. Neuroscience 103(1):161-9, 2001. e-Pub 2001. PMID: 11311797.
Luheshi GN, Bluthé RM, Rushforth D, Mulcahy N, Konsman JP, Goldbach M, Dantzer R. Vagotomy attenuates the behavioural but not the pyrogenic effects of interleukin-1 in rats. Auton Neurosci 85(1-3):127-32, 2000. e-Pub 2000. PMID: 11189019.
Bluthé RM, Layé S, Michaud B, Combe C, Dantzer R, Parnet P. Role of interleukin-1beta and tumour necrosis factor-alpha in lipopolysaccharide-induced sickness behaviour: a study with interleukin-1 type I receptor-deficient mice. Eur J Neurosci 12(12):4447-56, 2000. e-Pub 2000. PMID: 11122355.
Konsman JP, Luheshi GN, Bluthé RM, Dantzer R. The vagus nerve mediates behavioural depression, but not fever, in response to peripheral immune signals; a functional anatomical analysis. Eur J Neurosci 12(12):4434-46, 2000. e-Pub 2000. PMID: 11122354.
Pousset F, Palin K, Verrier D, Bristow A, Dantzer R, Parnet P, Lestage J. Production of interleukin-1 receptor antagonist isoforms by microglia in mixed rat glial cells stimulated by lipopolysaccharide. Eur Cytokine Netw 11(4):682-9, 2000. e-Pub 2000. PMID: 11125314.
Mattson MP, Barger SW, Dantzer R. Silencing survival data. Trends Neurosci 23(10):466-7, 2000. e-Pub 2000. PMID: 11203139.
Pousset F, Dantzer R, Kelley KW, Parnet P. Interleukin-1 signaling in mouse astrocytes involves Akt: a study with interleukin-4 and IL-10. Eur Cytokine Netw 11(3):427-34, 2000. e-Pub 2000. PMID: 11022128.
Bluthé RM, Michaud B, Poli V, Dantzer R. Role of IL-6 in cytokine-induced sickness behavior: a study with IL-6 deficient mice. Physiol Behav 70(3-4):367-73, 2000. e-Pub 2000. PMID: 11006436.
Layé S, Gheusi G, Cremona S, Combe C, Kelley K, Dantzer R, Parnet P. Endogenous brain IL-1 mediates LPS-induced anorexia and hypothalamic cytokine expression. Am J Physiol Regul Integr Comp Physiol 279(1):R93-8, 2000. e-Pub 2000. PMID: 10896869.
Bret-Dibat JL, Dantzer R. Cholecystokinin receptors do not mediate the suppression of food-motivated behavior by lipopolysaccharide and interleukin-1 beta in mice. Physiol Behav 69(3):325-31, 2000. e-Pub 2000. PMID: 10869599.
Capuron L, Ravaud A, Dantzer R. Early depressive symptoms in cancer patients receiving interleukin 2 and/or interferon alfa-2b therapy. J Clin Oncol 18(10):2143-51, 2000. e-Pub 2000. PMID: 10811680.
Schacher DH, VanHoy RW, Liu Q, Arkins S, Dantzer R, Freund GG, Kelley KW. Developmental expression of insulin receptor substrate-2 during dimethylsulfoxide-induced differentiation of human HL-60 cells. J Immunol 164(1):113-20, 2000. e-Pub 2000. PMID: 10605001.
Konsman JP, Tridon V, Dantzer R. Diffusion and action of intracerebroventricularly injected interleukin-1 in the CNS. Neuroscience 101(4):957-67, 2000. e-Pub 2000. PMID: 11113345.
Bluth, Jafarian-Tehrani M, Michaud B, Haour F, Dantzer R, Homo-Delarche F. Increased sensitivity of prediabetic nonobese diabetic mouse to the behavioral effects of IL-1. Brain Behav Immun 13(4):303-14, 1999. e-Pub 1999. PMID: 10600218.
Liu Q, VanHoy RW, Zhou JH, Dantzer R, Freund GG, Kelley KW. Elevated cyclin E levels, inactive retinoblastoma protein, and suppression of the p27(KIP1) inhibitor characterize early development of promyeloid cells into macrophages. Mol Cell Biol 19(9):6229-39, 1999. e-Pub 1999. PMID: 10454569.
Venters HD, Tang Q, Liu Q, VanHoy RW, Dantzer R, Kelley KW. A new mechanism of neurodegeneration: a proinflammatory cytokine inhibits receptor signaling by a survival peptide. Proc Natl Acad Sci U S A 96(17):9879-84, 1999. e-Pub 1999. PMID: 10449788.
Minshall C, Arkins S, Dantzer R, Freund GG, Kelley KW. Phosphatidylinositol 3'-kinase, but not S6-kinase, is required for insulin-like growth factor-I and IL-4 to maintain expression of Bcl-2 and promote survival of myeloid progenitors. J Immunol 162(8):4542-9, 1999. e-Pub 1999. PMID: 10201993.
Bluthé RM, Castanon N, Pousset F, Bristow A, Ball C, Lestage J, Michaud B, Kelley KW, Dantzer R. Central injection of IL-10 antagonizes the behavioural effects of lipopolysaccharide in rats. Psychoneuroendocrinology 24(3):301-11, 1999. e-Pub 1999. PMID: 10101735.
Konsman JP, Kelley K, Dantzer R. Temporal and spatial relationships between lipopolysaccharide-induced expression of Fos, interleukin-1beta and inducible nitric oxide synthase in rat brain. Neuroscience 89(2):535-48, 1999. e-Pub 1999. PMID: 10077334.
Capuron L, Lamarque D, Dantzer R, Goodall G. Attentional and mnemonic deficits associated with infectious disease in humans. Psychol Med 29(2):291-7, 1999. e-Pub 1999. PMID: 10218921.
Pousset F, Cremona S, Dantzer R, Kelley K, Parnet P. Interleukin-4 and interleukin-10 regulate IL1-beta induced mouse primary astrocyte activation: a comparative study. Glia 26(1):12-21, 1999. e-Pub 1999. PMID: 10088668.
Lenczowski MJ, Bluthé RM, Roth J, Rees GS, Rushforth DA, van Dam AM, Tilders FJ, Dantzer R, Rothwell NJ, Luheshi GN. Central administration of rat IL-6 induces HPA activation and fever but not sickness behavior in rats. Am J Physiol 276(3 Pt 2):R652-8, 1999. e-Pub 1999. PMID: 10070124.
Dantzer R, Gheusi G, Johnson RW, Kelley KW. Central administration of insulin-like growth factor-1 inhibits lipopolysaccharide-induced sickness behavior in mice. Neuroreport 10(2):289-92, 1999. e-Pub 1999. PMID: 10203323.
French RA, VanHoy RW, Chizzonite R, Zachary JF, Dantzer R, Parnet P, Bluthé RM, Kelley KW. Expression and localization of p80 and p68 interleukin-1 receptor proteins in the brain of adult mice. J Neuroimmunol 93(1-2):194-202, 1999. e-Pub 1999. PMID: 10378883.
Sipe KJ, Dantzer R, Kelley KW, Weyhenmeyer JA. Expression of the 75 kDA TNF receptor and its role in contact-mediated neuronal cell death. Brain Res Mol Brain Res 62(2):111-21, 1998. e-Pub 1998. PMID: 9813268.
Anforth HR, Bluthe RM, Bristow A, Hopkins S, Lenczowski MJ, Luheshi G, Lundkvist J, Michaud B, Mistry Y, Van Dam AM, Zhen C, Dantzer R, Poole S, Rothwell NJ, Tilders FJ, Wollman EE. Biological activity and brain actions of recombinant rat interleukin-1alpha and interleukin-1beta. Eur Cytokine Netw 9(3):279-88, 1998. e-Pub 1998. PMID: 9831177.
Burgess W, Gheusi G, Yao J, Johnson RW, Dantzer R, Kelley KW. Interleukin-1beta-converting enzyme-deficient mice resist central but not systemic endotoxin-induced anorexia. Am J Physiol 274(6 Pt 2):R1829-33, 1998. e-Pub 1998. PMID: 9841556.
Finck BN, Kelley KW, Dantzer R, Johnson RW. In vivo and in vitro evidence for the involvement of tumor necrosis factor-alpha in the induction of leptin by lipopolysaccharide. Endocrinology 139(5):2278-83, 1998. e-Pub 1998. PMID: 9564834.
Cremona S, Layé S, Dantzer R, Parnet P. Blockade of brain type II interleukin-1 receptors potentiates IL1beta-induced anorexia in mice. Neurosci Lett 246(2):101-4, 1998. e-Pub 1998. PMID: 9627190.
Dantzer R, Wollman E. Molecular mechanisms of fever: the missing links. Eur Cytokine Netw 9(1):27-31, 1998. e-Pub 1998. PMID: 9613674.
Cremona S, Goujon E, Kelley KW, Dantzer R, Parnet P. Brain type I but not type II IL-1 receptors mediate the effects of IL-1 beta on behavior in mice. Am J Physiol 274(3 Pt 2):R735-40, 1998. e-Pub 1998. PMID: 9530240.
Neveu PJ, Bluthé RM, Liège S, Moya S, Michaud B, Dantzer R. Interleukin-1-induced sickness behavior depends on behavioral lateralization in mice. Physiol Behav 63(4):587-90, 1998. e-Pub 1998. PMID: 9523902.
Liu Q, Ning W, Dantzer R, Freund GG, Kelley KW. Activation of protein kinase C-zeta and phosphatidylinositol 3'-kinase and promotion of macrophage differentiation by insulin-like growth factor-I. J Immunol 160(3):1393-401, 1998. e-Pub 1998. PMID: 9570559.
Aubert A, Kelley KW, Dantzer R. Differential effect of lipopolysaccharide on food hoarding behavior and food consumption in rats. Brain Behav Immun 11(3):229-38, 1997. e-Pub 1997. PMID: 9417807.
Minshall C, Arkins S, Straza J, Conners J, Dantzer R, Freund GG, Kelley KW. IL-4 and insulin-like growth factor-I inhibit the decline in Bcl-2 and promote the survival of IL-3-deprived myeloid progenitors. J Immunol 159(3):1225-32, 1997. e-Pub 1997. PMID: 9233617.
Bluthé RM, Michaud B, Kelley KW, Dantzer R. Cholecystokinin receptors do not mediate the behavioral effects of lipopolysaccharide in mice. Physiol Behav 62(2):385-9, 1997. e-Pub 1997. PMID: 9251984.
Liu Q, Schacher D, Hurth C, Freund GG, Dantzer R, Kelley KW. Activation of phosphatidylinositol 3'-kinase by insulin-like growth factor-I rescues promyeloid cells from apoptosis and permits their differentiation into granulocytes. J Immunol 159(2):829-37, 1997. e-Pub 1997. PMID: 9218601.
Aubert A, Goodall G, Dantzer R, Gheusi G. Differential effects of lipopolysaccharide on pup retrieving and nest building in lactating mice. Brain Behav Immun 11(2):107-18, 1997. e-Pub 1997. PMID: 9299060.
Finck BN, Dantzer R, Kelley KW, Woods JA, Johnson RW. Central lipopolysaccharide elevates plasma IL-6 concentration by an alpha-adrenoreceptor-mediated mechanism. Am J Physiol 272(6 Pt 2):R1880-7, 1997. e-Pub 1997. PMID: 9227603.
Segreti J, Gheusi G, Dantzer R, Kelley KW, Johnson RW. Defect in interleukin-1beta secretion prevents sickness behavior in C3H/HeJ mice. Physiol Behav 61(6):873-8, 1997. e-Pub 1997. PMID: 9177560.
Johnson RW, Gheusi G, Segreti S, Dantzer R, Kelley KW. C3H/HeJ mice are refractory to lipopolysaccharide in the brain. Brain Res 752(1-2):219-26, 1997. e-Pub 1997. PMID: 9106460.
Bluthé RM, Michaud B, Delhaye-Bouchaud N, Mariani J, Dantzer R. Hypersensitivity of lurcher mutant mice to the depressing effects of lipopolysaccharide and interleukin-1 on behaviour. Neuroreport 8(5):1119-22, 1997. e-Pub 1997. PMID: 9175096.
Dantzer R. Cytokines in the brain: neuropathological aspects. Mol Psychiatry 2(2):83, 1997. e-Pub 1997. PMID: 9106221.
Bluthé RM, Dantzer R, Kelley KW. Central mediation of the effects of interleukin-1 on social exploration and body weight in mice. Psychoneuroendocrinology 22(1):1-11, 1997. e-Pub 1997. PMID: 9141147.
Li YM, Schacher DH, Liu Q, Arkins S, Rebeiz N, McCusker RH, Dantzer R, Kelley KW. Regulation of myeloid growth and differentiation by the insulin-like growth factor I receptor. Endocrinology 138(1):362-8, 1997. e-Pub 1997. PMID: 8977425.
Bret-Dibat JL, Creminon C, Couraud JY, Kelley KW, Dantzer R, Kent S. Systemic capsaicin pretreatment fails to block the decrease in food-motivated behavior induced by lipopolysaccharide and interleukin-1beta. Brain Res Bull 42(6):443-9, 1997. e-Pub 1997. PMID: 9128919.
Bluthé RM, Michaud B, Kelley KW, Dantzer R. Vagotomy blocks behavioural effects of interleukin-1 injected via the intraperitoneal route but not via other systemic routes. Neuroreport 7(15-17):2823-7, 1996. e-Pub 1996. PMID: 8981475.
Terlouw EM, Kent S, Cremona S, Dantzer R. Effect of intracerebroventricular administration of vasopressin on stress-induced hyperthermia in rats. Physiol Behav 60(2):417-24, 1996. e-Pub 1996. PMID: 8840900.
Layé S, Goujon E, Combe C, VanHoy R, Kelley KW, Parnet P, Dantzer R. Effects of lipopolysaccharide and glucocorticoids on expression of interleukin-1 beta converting enzyme in the pituitary and brain of mice. J Neuroimmunol 68(1-2):61-6, 1996. e-Pub 1996. PMID: 8784261.
Bluthé RM, Michaud B, Kelley KW, Dantzer R. Vagotomy attenuates behavioural effects of interleukin-1 injected peripherally but not centrally. Neuroreport 7(9):1485-8, 1996. e-Pub 1996. PMID: 8856703.
Sipe KJ, Srisawasdi D, Dantzer R, Kelley KW, Weyhenmeyer JA. An endogenous 55 kDa TNF receptor mediates cell death in a neural cell line. Brain Res Mol Brain Res 38(2):222-32, 1996. e-Pub 1996. PMID: 8793110.
Dantzer R. Expanding the range of cytokines and cytokine receptors in the brain. Mol Psychiatry 1(2):98, 1996. e-Pub 1996. PMID: 9118331.
Goujon E, Parnet P, Layé S, Combe C, Dantzer R. Adrenalectomy enhances pro-inflammatory cytokines gene expression, in the spleen, pituitary and brain of mice in response to lipopolysaccharide. Brain Res Mol Brain Res 36(1):53-62, 1996. e-Pub 1996. PMID: 9011765.
Li YM, Arkins S, McCusker RH, Donovan SM, Liu Q, Jayaraman S, Dantzer R, Kelley KW. Macrophages synthesize and secrete a 25-kilodalton protein that binds insulin-like growth factor-I. J Immunol 156(1):64-72, 1996. e-Pub 1996. PMID: 8598495.
Goujon E, Parnet P, Cremona S, Dantzer R. Endogenous glucocorticoids down regulate central effects of interleukin-1 beta on body temperature and behaviour in mice. Brain Res 702(1-2):173-80, 1995. e-Pub 1995. PMID: 8846074.
Goujon E, Parnet P, Laye S, Combe C, Kelley KW, Dantzer R. Stress downregulates lipopolysaccharide-induced expression of proinflammatory cytokines in the spleen, pituitary, and brain of mice. Brain Behav Immun 9(4):292-303, 1995. e-Pub 1995. PMID: 8903847.
Bret-Dibat JL, Bluthé RM, Kent S, Kelley KW, Dantzer R. Lipopolysaccharide and interleukin-1 depress food-motivated behavior in mice by a vagal-mediated mechanism. Brain Behav Immun 9(3):242-6, 1995. e-Pub 1995. PMID: 8590821.
Goujon E, Parnet P, Aubert A, Goodall G, Dantzer R. Corticosterone regulates behavioral effects of lipopolysaccharide and interleukin-1 beta in mice. Am J Physiol 269(1 Pt 2):R154-9, 1995. e-Pub 1995. PMID: 7631887.
Aubert A, Vega C, Dantzer R, Goodall G. Pyrogens specifically disrupt the acquisition of a task involving cognitive processing in the rat. Brain Behav Immun 9(2):129-48, 1995. e-Pub 1995. PMID: 7549036.
Layé S, Bluthé RM, Kent S, Combe C, Médina C, Parnet P, Kelley K, Dantzer R. Subdiaphragmatic vagotomy blocks induction of IL-1 beta mRNA in mice brain in response to peripheral LPS. Am J Physiol 268(5 Pt 2):R1327-31, 1995. e-Pub 1995. PMID: 7771597.
Aubert A, Goodall G, Dantzer R. Compared effects of cold ambient temperature and cytokines on macronutrient intake in rats. Physiol Behav 57(5):869-73, 1995. e-Pub 1995. PMID: 7610137.
Bluthé RM, Beaudu C, Kelley KW, Dantzer R. Differential effects of IL-1ra on sickness behavior and weight loss induced by IL-1 in rats. Brain Res 677(1):171-6, 1995. e-Pub 1995. PMID: 7606464.
Gheusi G, Bluthe RM, Goodall G, Dantzer R. Social and individual recognition in rodents: Methodological aspects and neurobiological bases. Behav Processes 33(1-2):59-87, 1994. e-Pub 1994. PMID: 24925240.
Layé S, Parnet P, Goujon E, Dantzer R. Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of mice. Brain Res Mol Brain Res 27(1):157-62, 1994. e-Pub 1994. PMID: 7877446.
Parnet P, Amindari S, Wu C, Brunke-Reese D, Goujon E, Weyhenmeyer JA, Dantzer R, Kelley KW. Expression of type I and type II interleukin-1 receptors in mouse brain. Brain Res Mol Brain Res 27(1):63-70, 1994. e-Pub 1994. PMID: 7877456.
Kent S, Rodriguez F, Kelley KW, Dantzer R. Reduction in food and water intake induced by microinjection of interleukin-1 beta in the ventromedial hypothalamus of the rat. Physiol Behav 56(5):1031-6, 1994. e-Pub 1994. PMID: 7824567.
Bluthé RM, Walter V, Parnet P, Layé S, Lestage J, Verrier D, Poole S, Stenning BE, Kelley KW, Dantzer R. Lipopolysaccharide induces sickness behaviour in rats by a vagal mediated mechanism. C R Acad Sci III 317(6):499-503, 1994. e-Pub 1994. PMID: 7987701.
Bret-Dibat JL, Kent S, Couraud JY, Creminon C, Dantzer R. A behaviorally active dose of lipopolysaccharide increases sensory neuropeptides levels in mouse spinal cord. Neurosci Lett 173(1-2):205-9, 1994. e-Pub 1994. PMID: 7523997.
Gheusi G, Bluthe RM, Goodall G, Dantzer R. Ethological study of the effects of tetrahydroaminoacridine (THA) on social recognition in rats. Psychopharmacology (Berl) 114(4):644-50, 1994. e-Pub 1994. PMID: 7855227.
Liu Q, Arkins S, Biragyn A, Minshall C, Parnet P, Dantzer R, Kelley KW. Competitive reverse transcriptase-polymerase chain reaction using a synthetic internal RNA standard to quantitate transcripts for leukocyte-derived hormones. Neuroimmunomodulation 1(1):33-41, 1994. e-Pub 1994. PMID: 8528883.
Fu YK, Arkins S, Li YM, Dantzer R, Kelley KW. Reduction in superoxide anion secretion and bactericidal activity of neutrophils from aged rats: reversal by the combination of gamma interferon and growth hormone. Infect Immun 62(1):1-8, 1994. e-Pub 1994. PMID: 8262614.
Bluthé RM, Pawlowski M, Suarez S, Parnet P, Pittman Q, Kelley KW, Dantzer R. Synergy between tumor necrosis factor alpha and interleukin-1 in the induction of sickness behavior in mice. Psychoneuroendocrinology 19(2):197-207, 1994. e-Pub 1994. PMID: 8190839.
Parnet P, Brunke DL, Goujon E, Mainard JD, Biragyn A, Arkins S, Dantzer R, Kelley KW. Molecular identification of two types of interleukin-1 receptors in the murine pituitary gland. J Neuroendocrinol 5(2):213-9, 1993. e-Pub 1993. PMID: 7683560.
Bluthé RM, Dantzer R. Role of the vomeronasal system in vasopressinergic modulation of social recognition in rats. Brain Res 604(1-2):205-10, 1993. e-Pub 1993. PMID: 8457849.
Johnson RW, Curtis SE, Dantzer R, Bahr JM, Kelley KW. Sickness behavior in birds caused by peripheral or central injection of endotoxin. Physiol Behav 53(2):343-8, 1993. e-Pub 1993. PMID: 8446696.
Johnson RW, Curtis SE, Dantzer R, Kelley KW. Central and peripheral prostaglandins are involved in sickness behavior in birds. Physiol Behav 53(1):127-31, 1993. e-Pub 1993. PMID: 8434052.
Dantzer R. Psychoneuroendocrinology on the move. Psychoneuroendocrinology 18(1):1-2, 1993. e-Pub 1993. PMID: 8475221.
Bluthé RM, Gheusi G, Dantzer R. Gonadal steroids influence the involvement of arginine vasopressin in social recognition in mice. Psychoneuroendocrinology 18(4):323-35, 1993. e-Pub 1993. PMID: 8316618.
Bluthé RM, Dantzer R. Chronic intracerebral infusions of vasopressin and vasopressin antagonist modulate behavioral effects of interleukin-1 in rat. Brain Res Bull 29(6):897-900, 1992. e-Pub 1992. PMID: 1473021.
Kent S, Bluthe RM, Dantzer R, Hardwick AJ, Kelley KW, Rothwell NJ, Vannice JL. Different receptor mechanisms mediate the pyrogenic and behavioral effects of interleukin 1. Proc Natl Acad Sci U S A 89(19):9117-20, 1992. e-Pub 1992. PMID: 1409612.
Edwards CK, Arkins S, Yunger LM, Blum A, Dantzer R, Kelley KW. The macrophage-activating properties of growth hormone. Cell Mol Neurobiol 12(5):499-510, 1992. e-Pub 1992. PMID: 1468117.
Kent S, Kelley KW, Dantzer R. Effects of lipopolysaccharide on food-motivated behavior in the rat are not blocked by an interleukin-1 receptor antagonist. Neurosci Lett 145(1):83-6, 1992. e-Pub 1992. PMID: 1461574.
Edwards CK, Ghiasuddin SM, Yunger LM, Lorence RM, Arkins S, Dantzer R, Kelley KW. In vivo administration of recombinant growth hormone or gamma interferon activities macrophages: enhanced resistance to experimental Salmonella typhimurium infection is correlated with generation of reactive oxygen intermediates. Infect Immun 60(6):2514-21, 1992. e-Pub 1992. PMID: 1316877.
Li YM, Brunke DL, Dantzer R, Kelley KW. Pituitary epithelial cell implants reverse the accumulation of CD4-CD8- lymphocytes in thymus glands of aged rats. Endocrinology 130(5):2703-9, 1992. e-Pub 1992. PMID: 1572290.
Bluthé RM, Crestani F, Kelley KW, Dantzer R. Mechanisms of the behavioral effects of interleukin 1. Role of prostaglandins and CRF. Ann N Y Acad Sci 650:268-75, 1992. e-Pub 1992. PMID: 1605483.
Bluthé RM, Dantzer R, Kelley KW. Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysaccharide in rat. Brain Res 573(2):318-20, 1992. e-Pub 1992. PMID: 1387028.
Bluthé RM, Dantzer R. Chronic intracerebral infusions of vasopressin and vasopressin antagonist modulate social recognition in rat. Brain Res 572(1-2):261-4, 1992. e-Pub 1992. PMID: 1611520.
Verdoux H, Dantzer R, Bourgeois M. [Animal models in psychiatry]. Ann Med Psychol (Paris) 150(2-3):202-4; discussion 204-5, 1992. e-Pub 1992. PMID: 1343519.
Bluthé RM, Sparber S, Dantzer R. Modulation of the behavioural effects of interleukin-1 in mice by nitric oxide. Neuroreport 3(2):207-9, 1992. e-Pub 1992. PMID: 1377958.
Fu YK, Arkins S, Fuh G, Cunningham BC, Wells JA, Fong S, Cronin MJ, Dantzer R, Kelley KW. Growth hormone augments superoxide anion secretion of human neutrophils by binding to the prolactin receptor. J Clin Invest 89(2):451-7, 1992. e-Pub 1992. PMID: 1310696.
Bluthé RM, Dantzer R, Kelley KW. Interleukin-1 mediates behavioural but not metabolic effects of tumor necrosis factor alpha in mice. Eur J Pharmacol 209(3):281-3, 1991. e-Pub 1991. PMID: 1839150.
Bluthé RM, Koob GF, Dantzer R. Hypertonic saline mimics the effects of vasopressin and social recognition in rats. Behav Pharmacol 2(6):513-516, 1991. e-Pub 1991. PMID: 11224093.
Dantzer R. Stress, stereotypies and welfare. Behav Processes 25(2-3):95-102, 1991. e-Pub 1991. PMID: 24923969.
Dantzer R, Bluthe RM, Kelley KW. Androgen-dependent vasopressinergic neurotransmission attenuates interleukin-1-induced sickness behavior. Brain Res 557(1-2):115-20, 1991. e-Pub 1991. PMID: 1660748.
Edwards CK, Yunger LM, Lorence RM, Dantzer R, Kelley KW. The pituitary gland is required for protection against lethal effects of Salmonella typhimurium. Proc Natl Acad Sci U S A 88(6):2274-7, 1991. e-Pub 1991. PMID: 1900940.
Crestani F, Seguy F, Dantzer R. Behavioural effects of peripherally injected interleukin-1: role of prostaglandins. Brain Res 542(2):330-5, 1991. e-Pub 1991. PMID: 2029641.
Edwards CK, Lorence RM, Dunham DM, Arkins S, Yunger LM, Greager JA, Walter RJ, Dantzer R, Kelley KW. Hypophysectomy inhibits the synthesis of tumor necrosis factor alpha by rat macrophages: partial restoration by exogenous growth hormone or interferon gamma. Endocrinology 128(2):989-86, 1991. e-Pub 1991. PMID: 1899224.
Bluthé RM, Dantzer R, Kelley KW. [Dissociation between peripheral and central components of tolerance to behavior effects of interleukin-1 in rats]. C R Acad Sci III 312(13):689-94, 1991. e-Pub 1991. PMID: 1913242.
Bluthé RM, Dantzer R. Social recognition does not involve vasopressinergic neurotransmission in female rats. Brain Res 535(2):301-4, 1990. e-Pub 1990. PMID: 1963571.
Dunham DM, Arkins S, Edwards CK, Dantzer R, Kelley KW. Role of interferon-gamma in counteracting the suppressive effects of transforming growth factor-beta 2 and glucocorticoids on the production of tumor necrosis factor-alpha. J Leukoc Biol 48(6):473-81, 1990. e-Pub 1990. PMID: 2121884.
Dantzer R, Tazi A, Bluthé RM. Cerebral lateralization of olfactory-mediated affective processes in rats. Behav Brain Res 40(1):53-60, 1990. e-Pub 1990. PMID: 2278657.
Bluthe RM, Schoenen J, Dantzer R. Androgen-dependent vasopressinergic neurons are involved in social recognition in rats. Brain Res 519(1-2):150-7, 1990. e-Pub 1990. PMID: 1975762.
Dantzer R. [Stress, behavior and disease]. Gastroenterol Clin Biol 14(5 ( Pt 2)):13C-17C, 1990. e-Pub 1990. PMID: 2210176.
Perio A, Terranova JP, Worms P, Bluthe RM, Dantzer R, Biziere K. Specific modulation of social memory in rats by cholinomimetic and nootropic drugs, by benzodiazepine inverse agonists, but not by psychostimulants. Psychopharmacology (Berl) 97(2):262-8, 1989. e-Pub 1989. PMID: 2567026.
Tazi A, Dantzer R, Crestani F, Le Moal M. Interleukin-1 induces conditioned taste aversion in rats: a possible explanation for its pituitary-adrenal stimulating activity. Brain Res 473(2):369-71, 1988. e-Pub 1988. PMID: 3266091.
Dantzer R, Koob GF, Bluthé RM, Le Moal M. Septal vasopressin modulates social memory in male rats. Brain Res 457(1):143-7, 1988. e-Pub 1988. PMID: 3167559.
Tazi A, Dantzer R, Le Moal M. Schedule-induced polydipsia experience decreases locomotor response to amphetamine. Brain Res 445(2):211-5, 1988. e-Pub 1988. PMID: 3370459.
Kelley KW, Dantzer R. The importance of conditioning in conditioned immunosuppression. Int J Neurosci 39(3-4):289-97, 1988. e-Pub 1988. PMID: 3410646.
Dantzer R, Terlouw C, Mormède P, Le Moal M. Schedule-induced polydipsia experience decreases plasma corticosterone levels but increases plasma prolactin levels. Physiol Behav 43(3):275-9, 1988. e-Pub 1988. PMID: 3174840.
Dantzer R, Terlouw C, Tazi A, Koolhaas JM, Bohus B, Koob GF, Le Moal M. The propensity for schedule-induced polydipsia is related to differences in conditioned avoidance behaviour and in defense reactions in a defeat test. Physiol Behav 43(3):269-73, 1988. e-Pub 1988. PMID: 3174839.
Mormede P, Dantzer R, Michaud B, Kelley KW, Le Moal M. Influence of stressor predictability and behavioral control on lymphocyte reactivity, antibody responses and neuroendocrine activation in rats. Physiol Behav 43(5):577-83, 1988. e-Pub 1988. PMID: 3200912.
Tazi A, Dantzer R, Le Moal M, Rivier J, Vale W, Koob GF. Corticotropin-releasing factor antagonist blocks stress-induced fighting in rats. Regul Pept 18(1):37-42, 1987. e-Pub 1987. PMID: 3498188.
Le Moal M, Dantzer R, Michaud B, Koob GF. Centrally injected arginine vasopressin (AVP) facilitates social memory in rats. Neurosci Lett 77(3):353-9, 1987. e-Pub 1987. PMID: 3614767.
Meunier-Salaun MC, Vantrimponte MN, Raab A, Dantzer R. Effect of floor area restriction upon performance, behavior and physiology of growing-finishing pigs. J Anim Sci 64(5):1371-7, 1987. e-Pub 1987. PMID: 3583943.
Lebrun C, Le Moal M, Dantzer R, Bloom FE, Koob GF. Hypertonic saline mimics the effects of vasopressin on inhibitory avoidance in the rat. Behav Neural Biol 47(2):130-7, 1987. e-Pub 1987. PMID: 3579833.
Tazi A, Dantzer R, Le Moal M. Prediction and control of food rewards modulate endogenous pain inhibitory systems. Behav Brain Res 23(3):197-204, 1987. e-Pub 1987. PMID: 3580106.
Dantzer R, Gonyou HW, Curtis SE, Kelley KW. Changes in serum cortisol reveal functional differences in frustration-induced chain chewing in pigs. Physiol Behav 39(6):775-7, 1987. e-Pub 1987. PMID: 3602131.
Dantzer R, Bluthe RM, Koob GF, Le Moal M. Modulation of social memory in male rats by neurohypophyseal peptides. Psychopharmacology (Berl) 91(3):363-8, 1987. e-Pub 1987. PMID: 3104959.
Dantzer R, Satinoff E, Kelley KW. Cyclosporine and alpha-interferon do not attenuate morphine withdrawal in rats but do impair thermoregulation. Physiol Behav 39(5):593-8, 1987. e-Pub 1987. PMID: 3588704.
Neveu PJ, Taghzouti K, Dantzer R, Simon H, Le Moal M. Modulation of mitogen-induced lymphoproliferation by cerebral neocortex. Life Sci 38(21):1907-13, 1986. e-Pub 1986. PMID: 3487019.
Neveu PJ, Dantzer R, Le Moal M. Behaviorally conditioned suppression of mitogen-induced lymphoproliferation and antibody production in mice. Neurosci Lett 65(3):293-8, 1986. e-Pub 1986. PMID: 3086781.
Tazi A, Dantzer R, Mormede P, Le Moal M. Pituitary-adrenal correlates of schedule-induced polydipsia and wheel running in rats. Behav Brain Res 19(3):249-56, 1986. e-Pub 1986. PMID: 3964415.
Koob GF, Dantzer R, Bluthé RM, Lebrun C, Bloom FE, Le Moal M. Central injections of arginine vasopressin prolong extinction of active avoidance. Peptides 7(2):213-8, 1986. e-Pub 1986. PMID: 3737445.
Madec F, Cariolet R, Dantzer R. Relevance of some behavioural criteria concerning the sow (motor activity and water intake) in intensive pig farming and veterinary practice. Ann Rech Vet 17(2):177-84, 1986. e-Pub 1986. PMID: 3777811.
Dantzer R, Bluthé RM, Tazi A. Stress-induced analgesia in pigs. Ann Rech Vet 17(2):147-51, 1986. e-Pub 1986. PMID: 3777810.
Raab A, Dantzer R, Michaud B, Mormede P, Taghzouti K, Simon H, Le Moal M. Behavioural, physiological and immunological consequences of social status and aggression in chronically coexisting resident-intruder dyads of male rats. Physiol Behav 36(2):223-8, 1986. e-Pub 1986. PMID: 3960994.
Mormède P, LeMoal M, Dantzer R. Analysis of the dual mechanism of ACTH release by arginine vasopressin and its analogs in conscious rats. Regul Pept 12(3):175-84, 1985. e-Pub 1985. PMID: 3001841.
Bluthé RM, Dantzer R, Le Moal M. Peripheral injections of vasopressin control behavior by way of interoceptive signals for hypertension. Behav Brain Res 18(1):31-9, 1985. e-Pub 1985. PMID: 4091954.
Koob GF, Dantzer R, Rodriguez F, Bloom FE, Le Moal M. Osmotic stress mimics effects of vasopressin on learned behaviour. Nature 315(6022):750-2, 1985. e-Pub 1985. PMID: 4010780.
Tazi A, Dantzer R, Mormede P, Le Moal M. Effects of post-trial injection of beta-endorphin on shock-induced fighting are dependent on baseline of fighting. Behav Neural Biol 43(3):322-6, 1985. e-Pub 1985. PMID: 3842253.
Kelley KW, Dantzer R, Mormede P, Salmon H, Aynaud JM. Conditioned taste aversion suppresses induction of delayed-type hypersensitivity immune reactions. Physiol Behav 34(2):189-93, 1985. e-Pub 1985. PMID: 2987987.
Taghzouti K, Simon H, Tazi A, Dantzer R, Le Moal M. The effect of 6-OHDA lesions of the lateral septum on schedule-induced polydipsia. Behav Brain Res 15(1):1-8, 1985. e-Pub 1985. PMID: 3919740.
Koob GF, Lebrun C, Martinez JL, Dantzer R, Le Moal M, Bloom FE. Arginine vasopressin, stress, and memory. Ann N Y Acad Sci 444:194-202, 1985. e-Pub 1985. PMID: 3860087.
Tazi A, Dantzer R, Mormede P, Le Moal M. Effects of naloxone, beta-endorphin and ACTH on acquisition of schedule-induced polydipsia. Psychopharmacology (Berl) 85(1):87-91, 1985. e-Pub 1985. PMID: 2984711.
Chambon JP, Perio A, Demarne H, Hallot A, Dantzer R, Roncucci R, Bizière K. Ethyl loflazepate: a prodrug from the benzodiazepine series designed to dissociate anxiolytic and sedative activities. Arzneimittelforschung 35(10):1573-7, 1985. e-Pub 1985. PMID: 2866771.
Bluthé RM, Dantzer R, Mormède P, Le Moal M. Specificity of aversive stimulus properties of vasopressin. Psychopharmacology (Berl) 87(2):238-41, 1985. e-Pub 1985. PMID: 3931152.
Mormede P, Dantzer R, Perio A. Relationship of the effects of the benzodiazepine derivative clorazepate on corticosterone secretion with its behavioural actions. Antagonism by Ro 15-1788. Pharmacol Biochem Behav 21(6):839-43, 1984. e-Pub 1984. PMID: 6151666.
Mormède P, Dantzer R, Montpied P, Bluthé RM, Laplante E, LeMoal M. Influence of shock-induced fighting and social factors on pituitary-adrenal activity, prolactin and catecholamine synthesizing enzymes in rats. Physiol Behav 32(5):723-9, 1984. e-Pub 1984. PMID: 6093164.
Dantzer R, Guilloneau D, Mormède P, Herman JP, Le Moal M. Influence of shock-induced fighting and social factors on dopamine turnover in cortical and limbic areas in the rat. Pharmacol Biochem Behav 20(3):331-5, 1984. e-Pub 1984. PMID: 6538686.
Mormede P, Dantzer R, Bluthe R, Caritez J. Differences in adaptive abilities of three breeds of Chinese pigs. Behavioural and neuroendocrine studies. Genet Sel Evol (1983) 16(1):85-102, 1984. e-Pub 1984. PMID: 22879151.
Cariolet R, Dantzer R. Motor activity of pregnant tethered sows. Ann Rech Vet 15(2):257-61, 1984. e-Pub 1984. PMID: 6541446.
Le Moal M, Dantzer R, Mormède P, Baduel A, Lebrun C, Ettenberg A, van der Kooy D, Wenger J, Deyo S, Koob GF. Behavioral effects of peripheral administration of arginine vasopressin: a review of our search for a mode of action and a hypothesis. Psychoneuroendocrinology 9(4):319-41, 1984. e-Pub 1984. PMID: 6514931.
Kelley KW, Dantzer R, Mormède P, Salmon H, Aynaud JM. [Induction of immunosuppression by dietary aversion acquired in the absence of immunosuppressive treatment]. C R Acad Sci III 299(5):123-6, 1984. e-Pub 1984. PMID: 6088007.
Tazi A, Dantzer R, Mormède P, Le Moal M. Effects of post-trial administration of naloxone and beta-endorphin on shock-induced fighting in rats. Behav Neural Biol 39(2):192-202, 1983. e-Pub 1983. PMID: 6322740.
Dantzer R, Mormède P, Bluthé RM, Soissons J. The effect of different housing conditions on behavioural and adrenocortical reactions in veal calves. Reprod Nutr Dev 23(3):501-8, 1983. e-Pub 1983. PMID: 6310711.
Dantzer R. [Peptides and anxiety]. Encephale 9(4 Suppl 2):177B-182B, 1983. e-Pub 1983. PMID: 6144513.
Dantzer R, Pério A. Behavioural evidence for partial agonist properties of RO 15-1788, a benzodiazepine receptor antagonist. Eur J Pharmacol 81(4):655-8, 1982. e-Pub 1982. PMID: 6811297.
Herman JP, Guillonneau D, Dantzer R, Scatton B, Semerdjian-Rouquier L, Le Moal M. Differential effects of inescapable footshocks and of stimuli previously paired with inescapable footshocks on dopamine turnover in cortical and limbic areas of the rat. Life Sci 30(25):2207-14, 1982. e-Pub 1982. PMID: 6180276.
Mormede P, Soissons J, Bluthe RM, Raoult J, Legarff G, Levieux D, Dantzer R. Effect of transportation on blood serum composition, disease incidence, and production traits in young calves. Influence of the journey duration. Ann Rech Vet 13(4):369-84, 1982. e-Pub 1982. PMID: 7185323.
Dantzer R. [Recent trends in psychophysiology of anxiety (author's transl)]. Encephale 8(2):107-18, 1982. e-Pub 1982. PMID: 6286275.
Dantzer R, Mormède P. Pituitary-adrenal consequences of adjunctive activities in pigs. Horm Behav 15(4):386-95, 1981. e-Pub 1981. PMID: 7327534.
Dantzer R, Hatey F. Plasma dopamine-beta-hydroxylase and platelet monoamine oxidase activities in pigs with different susceptibility to the malignant hyperthermia syndrome by halothane. Reprod Nutr Dev 21(1):103-8, 1981. e-Pub 1981. PMID: 7349519.
Dantzer R, Mormède P. [Influence of weaning method on the behavior and the hypophyseal-adrenal axis activity in the piglet]. Reprod Nutr Dev 21(5A):661-70, 1981. e-Pub 1981. PMID: 7349550.
Dantzer R. Conditioned taste aversion as an index of lead toxicity. Pharmacol Biochem Behav 13(1):133-5, 1980. e-Pub 1980. PMID: 7403215.
Arnone M, Dantzer R. Effects of diazepam on extinction induced aggression in pigs. Pharmacol Biochem Behav 13(1):27-30, 1980. e-Pub 1980. PMID: 7190708.
Dantzer R, Arnone M, Mormede P. Effects of frustration on behaviour and plasma corticosteroid levels in pigs. Physiol Behav 24(1):1-4, 1980. e-Pub 1980. PMID: 7189887.
Dantzer R. [Involvement of endorphins in the emotional behavior of pigs]. C R Seances Acad Sci D 289(16):1299-302, 1979. e-Pub 1979. PMID: 232430.
Morméde P, Dantzer R. [Effect of a tryptophan lead on the swine adrenal cortex reactivity and behavioral response to stress]. C R Seances Soc Biol Fil 173(3):569-75, 1979. e-Pub 1979. PMID: 160272.
Dantzer R, Camguilhem R. [Behavioral alterations induced by post-natal exposure of the rat to lead]. C R Seances Soc Biol Fil 173(3):592-9, 1979. e-Pub 1979. PMID: 160274.
Mormède P, Dantzer R. Effects of dexamethasone on discriminative fear conditioning in pigs. Physiol Behav 21(2):279-81, 1978. e-Pub 1978. PMID: 693655.
Mormède P, Dantzer R. Pituitary--adrenal influences on avoidance behavior of pigs. Horm Behav 10(3):285-97, 1978. e-Pub 1978. PMID: 213367.
Dantzer R. Antipunishment effects of diazepam: interaction with shock and food deprivation levels in pigs. Psychopharmacology (Berl) 58(1):99-104, 1978. e-Pub 1978. PMID: 97726.
Dantzer R. Increased resistance to satiation in diazepam-treated pigs. Experientia 34(1):81-2, 1978. e-Pub 1978. PMID: 620746.
Mormede P, Dantzer R. Behavioural and pituitary-adrenal characteristics of pigs differing by their susceptibility to the malignant hyperthermia syndrome induced by halothane anesthesia. 2. Pituitary-adrenal function. Ann Rech Vet 9(3):569-76, 1978. e-Pub 1978. PMID: 219755.
Dantzer R, Mormede P. Behavioural and pituitary-adrenal characteristics of pigs differing by their susceptibility to the malignant hyperthermia syndrome induced by halothane anesthesia. 1. Behavioural measures. Ann Rech Vet 9(3):559-67, 1978. e-Pub 1978. PMID: 749649.
Mormede P, Dantzer R. Effects of dexamethasone on fear conditioning in pigs. Behav Biol 21(2):225-35, 1977. e-Pub 1977. PMID: 911286.
Dantzer R. [Effects of diazepam on exploratory behavior of pigs (author's transl)]. Psychopharmacology (Berl) 51(3):317-21, 1977. e-Pub 1977. PMID: 403550.
Dantzer R. Effects of diazepam on behaviour suppressed by extinction in pigs. Pharmacol Biochem Behav 6(2):157-61, 1977. e-Pub 1977. PMID: 870903.
Dantzer R, Mormede P. Fear-dependent variations in continuous avoidance behavior of pigs. I. Lack of effect of diazepam on performance of discriminative fear conditioning. Psychopharmacology (Berl) 49(1):69-73, 1976. e-Pub 1976. PMID: 822450.
Dantzer R, Mormede P, Favre B. Fear-dependent variations in continuous avoidance behavior of pigs. II. Effects of diazepam on acquisition and performance of Pavlovian fear conditioning and plasma corticosteroid levels. Psychopharmacology (Berl) 49(1):75-8, 1976. e-Pub 1976. PMID: 822451.
Dantzer R. Effect of diazepam on performance of pigs in a progressive ratio schedule. Physiol Behav 17(1):161-3, 1976. e-Pub 1976. PMID: 996143.
Dantzer R. Environment and behaviour in husbandry. Folia Vet Lat 6(1):76-90, 1976. e-Pub 1976. PMID: 1010499.
Dantzer R. [Absence of propranolol deinhibitor effect on punishment behavior in pigs]. Therapie(4):585-9, 1975. e-Pub 1975. PMID: 1209532.
Dantzer R. [Sequential analysis of effectiveness of diazepam, a tranquilizer, on stress in swine (author's transl)]. Ann Rech Vet 6(2):165-71, 1975. e-Pub 1975. PMID: 1099975.
Dantzer R, Baldwin BA. Effects of chlordiazepoxide on heart rate and behavioural suppression in pigs subjected to operant conditioning procedures. Psychopharmacologia 37(4):169-77, 1974. e-Pub 1974. PMID: 4844121.
Dantzer R, Baldwin BA. Changes in heart rate during suppression of operant responding in pigs. Physiol Behav 12(3):385-91, 1974. e-Pub 1974. PMID: 4820135.
Hachet T, Dantzer R. The use of a small computer for the automatic control of operant behavioural experiments (author's transl)]. J Physiol (Paris) 68(6):705-10, 1974. e-Pub 1974. PMID: 4463238.
Dantzer R, Roca M. Tranquilizing effects of diazepam in pigs subjected to a punishment procedure. Psychopharmacologia 40(3):235-40, 1974. e-Pub 1974. PMID: 4445450.
Dantzer R. [Stabilization of locomotor activity rhythms of piglets introduced into a new environment]. J Physiol (Paris) 66(5):495-503, 1973. e-Pub 1973. PMID: 4793607.
Dantzer R, Mailhé G. [Demonstration of a rhythm in motor activity behavior in young swine]. C R Seances Soc Biol Fil 166(2):456-60, 1972. e-Pub 1972. PMID: 4662021.
Dantzer R, Delacour J. [Modification of a phenomena of conditioned suppression by a thalamic lesion]. Physiol Behav 8(6):997-1003, 1972. e-Pub 1972. PMID: 5074038.
Dantzer R, Mailhé G. [Determination of the activity of piglets by means of an actographic device with photoelectric cells]. C R Seances Soc Biol Fil 166(1):196-200, 1972. e-Pub 1972. PMID: 4640405.
Poirel C, Dantzer R. Psychophysiological research on circadian rhythms in epilepsy]. Presse Med 79(48):2175-7, 1971. e-Pub 1971. PMID: 5139606.
Dantzer R, Delacour J. Effects of lesions of the median hypothalamus on the conditioned emotional reaction in the white rat] (Fre]. C R Acad Sci Hebd Seances Acad Sci D 272(9):1288-91, 1971. e-Pub 1971. PMID: 4994737.
Dantzer R. Weight losses sustained by young pigs during transit]. Ann Rech Vet 1(2):179-87, 1970. e-Pub 1970. PMID: 5526775.
Dantzer R, Poirel C. Controlled action of phenobarbital on acoustic epilepsy in mice]. C R Seances Soc Biol Fil 163(6):1435-9, 1969. e-Pub 1969. PMID: 4259315.

Invited Articles

McEwen BB. Research Contributions of Dantzer, Bluthe, and Colleagues to the Study of the Role of Vasopressin in Olfactory-Based Social Recognition Memory. Adv Pharmacol(50):453-474, 2004. e-Pub 2004. PMID: 15350268.

Review Articles

Abe L, Dantzer R. The role of FGF21 in the metabolic adjustments required for exercise capacity. Life Sci 380:123940, 2025. e-Pub 2025. PMID: 40886940.
Komaroff AL, Dantzer R. Causes of symptoms and symptom persistence in long COVID and myalgic encephalomyelitis/chronic fatigue syndrome. Cell Rep Med 6(8):102259, 2025. e-Pub 2025. PMID: 40744021.
Miller AH, Berk M, Bloch G, Briquet-Laugier V, Brouillon C, Cuthbert BN, Dantzer R, Davis MC, De Picker LJ, Drevets WC, Eyre HA, Hack LM, Harrison NA, Krystal AD, Lombardo G, Mondelli V, Pariante CM, Pulvirenti L, Salvadore G, Sforzini L, Swieboda P, Trivedi MH, Leboyer M. Advancing precision psychiatry and targeted treatments: Insights from immunopsychiatry. Brain Behav Immun 125:319-329, 2025. e-Pub 2025. PMID: 39828008.
Dantzer R, Chelette B, Vichaya EG, West AP, Grossberg A. The metabolic basis of cancer-related fatigue. Neurosci Biobehav Rev 169:106035, 2025. e-Pub 2025. PMID: 39892436.
Raizen DM, Mullington J, Anaclet C, Clarke G, Critchley H, Dantzer R, Davis R, Drew KL, Fessel J, Fuller PM, Gibson EM, Harrington M, Lipkin WI, Klerman EB, Klimas N, Komaroff AL, Koroshetz W, Krupp L, Kuppuswamy A, Lasselin J, Lewis LD, Magistretti PJ, Matos HY, Miaskowski C, Miller AH, Nath A, Nedergaard M, Opp MR, Ritchie MD, Rogulja D, Rolls A, Salamone JD, Saper C, Whittemore V, Wylie G, Younger J, Zee PC, Heller HC. Beyond the Symptom: The Biology of Fatigue. Sleep 46(9), 2023. e-Pub 2023. PMID: 37224457.
Banerjee P, Rosales JE, Chau K, Nguyen MTH, Kotla S, Lin SH, Deswal A, Dantzer R, Olmsted-Davis EA, Nguyen H, Wang G, Cooke JP, Abe JI, Le NT. Possible molecular mechanisms underlying the development of atherosclerosis in cancer survivors. Front Cardiovasc Med 10:1186679, 2023. e-Pub 2023. PMID: 37332576.
Dantzer R. Evolutionary Aspects of Infections: Inflammation and Sickness Behaviors. Curr Top Behav Neurosci 61:1-14, 2023. e-Pub 2023. PMID: 35505054.
Casaril AM, Dantzer R, Bas-Orth C. Neuronal Mitochondrial Dysfunction and Bioenergetic Failure in Inflammation-Associated Depression. Front Neurosci 15:725547, 2021. e-Pub 2021. PMID: 34790089.
Hunt C, Macedo E Cordeiro T, Suchting R, de Dios C, Cuellar Leal VA, Soares JC, Dantzer R, Teixeira AL, Selvaraj S. Effect of mmune Activation on the Kynurenine Pathway and Depression Symptoms - A Systematic Review and Meta-Analysis. Neurosci Biobehav Rev 118:514-523, 2020. e-Pub 2020. PMID: 32853625.
Dantzer R, Cohen S, Russo SJ, Dinan TG. Resilience and immunity. Brain Behav Immun 74:28-42, 2018. e-Pub 2018. PMID: 30102966.
Drummond JB, Barbosa IG, Dantzer R, Teixeira AL. The effect of insulin-induced hypoglycemia on inflammatory markers: a systematic review. Brain Behav Immun 73:41-50, 2018. e-Pub 2018. PMID: 29733946.
Arnone D, Saraykar S, Salem H, Teixeira AL, Dantzer R, Selvaraj S. Role of kynurenine pathway and its metabolites in mood disorders: a systematic review and meta-analysis of clinical studies. Neurosci Biobehav Rev 92:477-485, 2018. e-Pub 2018. PMID: 29940237.
De Doncker W, Dantzer R, Ormstad H, Kuppuswamy A. Mechanisms of poststroke fatigue. J Neurol Neurosurg Psychiatry 89(3):287-293, 2018. e-Pub 2018. PMID: 28939684.
Lacourt TE, Vichaya EG, Chiu GS, Dantzer R, Heijnen CJ. The high costs of low-grade inflammation: persistent fatigue as a consequence of reduced cellular-energy availability and non-adaptive energy expenditure. Front Behav Neurosci 12:78, 2018. e-Pub 2018. PMID: 29755330.
Vichaya EG, Chiu GS, Krukowski K, Lacourt TE, Kavelaars A, Dantzer R, Heijnen CJ, Walker AK. Mechanisms of chemotherapy-induced behavioral toxicities. Front Neurosci 9:131, 2015. e-Pub 2015. PMID: 25954147.
Kelley KW, Dantzer R. Alcoholism and inflammation: neuroimmunology of behavioral and mood disorders. Brain Behav Immun 25 Suppl 1:S13-20, 2011. e-Pub 2011. PMID: 21193024.
Dantzer R, O'Connor JC, Lawson MA, Kelley KW. Inflammation-associated depression: from serotonin to kynurenine. Psychoneuroendocrinology 36(3):426-36, 2011. e-Pub 2011. PMID: 21041030.
O'Connor JC, McCusker RH, Strle K, Johnson RW, Dantzer R, Kelley KW. Regulation of IGF-I function by proinflammatory cytokines: at the interface of immunology and endocrinology. Cell Immunol 252(1-2):91-110, 2008. e-Pub 2008. PMID: 18325486.
Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9(1):46-56, 2008. e-Pub 2008. PMID: 18073775.
Dimsdale JE, Dantzer R. A biological substrate for somatoform disorders: importance of pathophysiology. Psychosom Med 69(9):850-4, 2007. e-Pub 2007. PMID: 18040093.
Dantzer R. Cytokine, sickness behavior, and depression. Neurol Clin 24(3):441-60, 2006. e-Pub 2006. PMID: 16877117.
Dantzer R. Somatization: a psychoneuroimmune perspective. Psychoneuroendocrinology 30(10):947-52, 2005. e-Pub 2005. PMID: 15949897.
Bartolomucci A, Palanza P, Sacerdote P, Panerai AE, Sgoifo A, Dantzer R, Parmigiani S. Social factors and individual vulnerability to chronic stress exposure. Neurosci Biobehav Rev 29(1):67-81, 2005. e-Pub 2005. PMID: 15652256.
Dantzer R. Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunity. Eur J Pharmacol 500(1-3):399-411, 2004. e-Pub 2004. PMID: 15464048.
Lee BN, Dantzer R, Langley KE, Bennett GJ, Dougherty PM, Dunn AJ, Meyers CA, Miller AH, Payne R, Reuben JM, Wang XS, Cleeland CS. A cytokine-based neuroimmunologic mechanism of cancer-related symptoms. Neuroimmunomodulation 11(5):279-92, 2004. e-Pub 2004. PMID: 15316238.
Capuron L, Dantzer R. Cytokines and depression: the need for a new paradigm. Brain Behav Immun 17 Suppl 1:S119-24, 2003. e-Pub 2003. PMID: 12615197.
Kelley KW, Bluthé RM, Dantzer R, Zhou JH, Shen WH, Johnson RW, Broussard SR. Cytokine-induced sickness behavior. Brain Behav Immun 17 Suppl 1:S112-8, 2003. e-Pub 2003. PMID: 12615196.
Capuron L, Dantzer R, Miller AH. [Neuro-immune interactions in psychopathology with the example of interferon-alpha-induced depression]. J Soc Biol 197(2):151-6, 2003. e-Pub 2003. PMID: 12910630.
Dantzer R, Wollman EE. [Relationships between the brain and the immune system]. J Soc Biol 197(2):81-8, 2003. e-Pub 2003. PMID: 12910622.
Parnet P, Kelley KW, Bluthé RM, Dantzer R. Expression and regulation of interleukin-1 receptors in the brain. Role in cytokines-induced sickness behavior. J Neuroimmunol 125(1-2):5-14, 2002. e-Pub 2002. PMID: 11960635.
Konsman JP, Parnet P, Dantzer R. Cytokine-induced sickness behaviour: mechanisms and implications. Trends Neurosci 25(3):154-9, 2002. e-Pub 2002. PMID: 11852148.
Venters HD, Broussard SR, Zhou JH, Bluthé RM, Freund GG, Johnson RW, Dantzer R, Kelley KW. Tumor necrosis factor(alpha) and insulin-like growth factor-I in the brain: is the whole greater than the sum of its parts?. J Neuroimmunol 119(2):151-65, 2001. e-Pub 2001. PMID: 11585617.
Konsman JP, Dantzer R. How the immune and nervous systems interact during disease-associated anorexia. Nutrition 17(7-8):664-8, 2001. e-Pub 2001. PMID: 11448593.
Dantzer R. Cytokine-induced sickness behavior: mechanisms and implications. Ann N Y Acad Sci 933:222-34, 2001. e-Pub 2001. PMID: 12000023.
Dantzer R. Cytokine-induced sickness behavior: where do we stand?. Brain Behav Immun 15(1):7-24, 2001. e-Pub 2001. PMID: 11259077.
Strle K, Zhou JH, Shen WH, Broussard SR, Johnson RW, Freund GG, Dantzer R, Kelley KW. Interleukin-10 in the brain. Crit Rev Immunol 21(5):427-49, 2001. e-Pub 2001. PMID: 11942558.
Dantzer R, Konsman JP, Bluthé RM, Kelley KW. Neural and humoral pathways of communication from the immune system to the brain: parallel or convergent?. Auton Neurosci 85(1-3):60-5, 2000. e-Pub 2000. PMID: 11189027.
Vitkovic L, Konsman JP, Bockaert J, Dantzer R, Homburger V, Jacque C. Cytokine signals propagate through the brain. Mol Psychiatry 5(6):604-15, 2000. e-Pub 2000. PMID: 11126391.
Venters HD, Dantzer R, Kelley KW. A new concept in neurodegeneration: TNFalpha is a silencer of survival signals. Trends Neurosci 23(4):175-80, 2000. e-Pub 2000. PMID: 10717677.
Venters HD, Dantzer R, Kelley KW. Tumor necrosis factor-alpha induces neuronal death by silencing survival signals generated by the type I insulin-like growth factor receptor. Ann N Y Acad Sci 917:210-20, 2000. e-Pub 2000. PMID: 11268346.
Dantzer R, Wollman E, Vitkovic L, Yirmiya R. Cytokines and depression: fortuitous or causative association?. Mol Psychiatry 4(4):328-32, 1999. e-Pub 1999. PMID: 10483048.
Burgess W, Liu Q, Zhou J, Tang Q, Ozawa A, VanHoy R, Arkins S, Dantzer R, Kelley KW. The immune-endocrine loop during aging: role of growth hormone and insulin-like growth factor-I. Neuroimmunomodulation 6(1-2):56-68, 1999. e-Pub 1999. PMID: 9876236.
Dantzer R, Wollman EE, Vitkovic L, Yirmiya R. Cytokines, stress, and depression. Conclusions and perspectives. Adv Exp Med Biol 461:317-29, 1999. e-Pub 1999. PMID: 10442180.
Dantzer R, Aubert A, Bluthé RM, Gheusi G, Cremona S, Layé S, Konsman JP, Parnet P, Kelley KW. Mechanisms of the behavioural effects of cytokines. Adv Exp Med Biol 461:83-105, 1999. e-Pub 1999. PMID: 10442169.
Dantzer R, Bluthé RM, Gheusi G, Cremona S, Layé S, Parnet P, Kelley KW. Molecular basis of sickness behavior. Ann N Y Acad Sci 856:132-8, 1998. e-Pub 1998. PMID: 9917873.
Dantzer R, Bluthé RM, Layé S, Bret-Dibat JL, Parnet P, Kelley KW. Cytokines and sickness behavior. Ann N Y Acad Sci 840:586-90, 1998. e-Pub 1998. PMID: 9629285.
Kelley KW, Meier WA, Minshall C, Schacher DH, Liu Q, VanHoy R, Burgess W, Dantzer R. Insulin growth factor-I inhibits apoptosis in hematopoietic progenitor cells. Implications in thymic aging. Ann N Y Acad Sci 840:518-24, 1998. e-Pub 1998. PMID: 9629278.
Dantzer R. Vasopressin, gonadal steroids and social recognition. Prog Brain Res 119:409-14, 1998. e-Pub 1998. PMID: 10074803.
Kelley KW, Hutchison K, French R, Bluthé RM, Parnet P, Johnson RW, Dantzer R. Central interleukin-1 receptors as mediators of sickness. Ann N Y Acad Sci 823:234-46, 1997. e-Pub 1997. PMID: 9292049.
Johnson RW, Arkins S, Dantzer R, Kelley KW. Hormones, lymphohemopoietic cytokines and the neuroimmune axis. Comp Biochem Physiol A Physiol 116(3):183-201, 1997. e-Pub 1997. PMID: 9102183.
Dantzer R. Stress and immunity: what have we learned from psychoneuroimmunology?. Acta Physiol Scand Suppl 640:43-6, 1997. e-Pub 1997. PMID: 9401604.
Goujon E, Layé S, Parnet P, Dantzer R. Regulation of cytokine gene expression in the central nervous system by glucocorticoids: mechanisms and functional consequences. Psychoneuroendocrinology 22 Suppl 1:S75-80, 1997. e-Pub 1997. PMID: 9264151.
French RA, Zachary JF, Dantzer R, Frawley LS, Chizzonite R, Parnet P, Kelley KW. Dual expression of p80 type I and p68 type II interleukin-I receptors on anterior pituitary cells synthesizing growth hormone. Endocrinology 137(9):4027-36, 1996. e-Pub 1996. PMID: 8756580.
Kelley KW, Arkins S, Minshall C, Liu Q, Dantzer R. Growth hormone, growth factors and hematopoiesis. Horm Res 45(1-2):38-45, 1996. e-Pub 1996. PMID: 8742117.
Kent S, Bret-Dibat JL, Kelley KW, Dantzer R. Mechanisms of sickness-induced decreases in food-motivated behavior. Neurosci Biobehav Rev 20(1):171-5, 1996. e-Pub 1996. PMID: 8622824.
Dantzer R. [Stress theories and the somatization process]. Encephale 21 Spec No 7:3-9, 1995. e-Pub 1995. PMID: 8929672.
Dantzer R. [Current studies on the neurobiology of chronic fatigue syndrome]. Encephale 20 Spec No 3:597-602, 1994. e-Pub 1994. PMID: 7843056.
Dantzer R. [Neurotropic effects of cytokines: at the limits of immunology and neurobiology]. Pathol Biol (Paris) 42(9):826-9, 1994. e-Pub 1994. PMID: 7753590.
Kelley KW, Johnson RW, Dantzer R. Immunology discovers physiology. Vet Immunol Immunopathol 43(1-3):157-65, 1994. e-Pub 1994. PMID: 7856048.
Dantzer R. How do cytokines say hello to the brain? Neural versus humoral mediation. Eur Cytokine Netw 5(3):271-3, 1994. e-Pub 1994. PMID: 7948764.
Dantzer R. Animal welfare methodology and criteria. Rev Sci Tech 13(1):277-302, 1994. e-Pub 1994. PMID: 8173101.
Arkins S, Dantzer R, Kelley KW. Somatolactogens, somatomedins, and immunity. J Dairy Sci 76(8):2437-50, 1993. e-Pub 1993. PMID: 8408873.
Dantzer R, Bluthé RM. Vasopressin and behavior: from memory to olfaction. Regul Pept 45(1-2):121-5, 1993. e-Pub 1993. PMID: 8511333.
Kent S, Bluthé RM, Kelley KW, Dantzer R. Sickness behavior as a new target for drug development. Trends Pharmacol Sci 13(1):24-8, 1992. e-Pub 1992. PMID: 1542935.
Dantzer R, Bluthé RM. Vasopressin involvement in antipyresis, social communication, and social recognition: a synthesis. Crit Rev Neurobiol 6(4):243-55, 1992. e-Pub 1992. PMID: 1423692.
Kelley KW, Dantzer R. Neuroendocrine-immune interactions. Adv Vet Sci Comp Med 35:283-305, 1990. e-Pub 1990. PMID: 2284997.
Koob GF, Lebrun C, Bluthé RM, Dantzer R, Le Moal M. Role of neuropeptides in learning versus performance: focus on vasopressin. Brain Res Bull 23(4-5):359-64, 1989. e-Pub 1989. PMID: 2686806.
Dantzer R, Kelley KW. Stress and immunity: an integrated view of relationships between the brain and the immune system. Life Sci 44(26):1995-2008, 1989. e-Pub 1989. PMID: 2568569.
Dantzer R, Bluthe RM, LeMoal M. Experimental assessment of drug-induced changes in cognitive function: vasopressin as a case study. Neurotoxicology 9(3):471-7, 1988. e-Pub 1988. PMID: 3059246.
Dantzer R. The pig as a model for behavioral research. Lab Anim Sci 36(4):362-5, 1986. e-Pub 1986. PMID: 3534439.
Dantzer R. Behavioral, physiological and functional aspects of stereotyped behavior: a review and a re-interpretation. J Anim Sci 62(6):1776-86, 1986. e-Pub 1986. PMID: 3525490.
Dantzer R, Mormède P. Stress in farm animals: a need for reevaluation. J Anim Sci 57(1):6-18, 1983. e-Pub 1983. PMID: 6350254.
Dantzer R. Dissociation between suppressive and facilitating effects of aversive stimuli on behavior by benzodiazepines. A review and reinterpretation. Prog Neuropsychopharmacol 2(1):33-40, 1978. e-Pub 1978. PMID: 364512.

Editorials

Dantzer R. Vers une psychiatrie de precision ?. Med Sci (Paris) 41(5):407-408, 2025. PMID: 40418000.
Dantzer R. A Festschrift for Janice Kiecolt-Glaser: At the origin of stress and immunity. Compr Psychoneuroendocrinol 20:100277, 2024. PMID: 39801535.
Dantzer R. Mental health, war trauma, and migration: The contribution of Comprehensive Psychoneuroendocrinology. Compr Psychoneuroendocrinol 13:100168, 2023. PMID: 36873730.
Dantzer R. Editorial. Psychoneuroendocrinology 145:105941, 2022. PMID: 36184378.
Dantzer R. Psychoneuroendocrinology in 2022. Psychoneuroendocrinology 143:105865, 2022. PMID: 35839601.
Carter CS, Dantzer R. Love and fear: A special issue. Compr Psychoneuroendocrinol 11:100151, 2022. PMID: 35967926.
Fleshner M, Epperson N, Dantzer R. Those we have lost: Dr. Mark L. Laudenslager. Psychoneuroendocrinology 124:105126, 2021. PMID: 34131360.
Dantzer R, Heuser I, Lupien S. Covid-19: An Urgent Need For A Psychoneuroendocrine Perspective. Psychoneuroendocrinology 116:104703, 2020. PMID: 32387180.
Dantzer R, Heuser I, Lupien S. Covid-19: An urgent need for a psychoneuroendocrine perspective. Compr Psychoneuroendocrinol 1:100003, 2020. PMID: 34173564.
Dantzer R, Kalin NH. The cortisol awakening response at its best. Psychoneuroendocrinology 63:412-3, 2016. PMID: 26604094.
Dantzer R, Kalin N. Invitation to submit papers for a new "How to" special series in Psychoneuroendocrinology. Psychoneuroendocrinology 38(3):311, 2013. PMID: 23465351.
Dantzer R. Depression and inflammation: an intricate relationship. Biol Psychiatry 71(1):4-5, 2012. PMID: 22137156.

Abstracts

Vichaya EG, Estrada DJ, Ford BG, Molkentine JM, Vermeer DW, Vermeer PD, Taniguchi CM, Dantzer R. Sex as a biological variable in cancer-related fatigue [abstract]. Psychoneuroimmunology Research Society (PNIRS) 25th Annual Scientific Meeting, Miama Beach FL, Jun 6-9, 2018. Brain Behav Immun 75(Supplement), 2018. e-Pub 2018.
Vichaya EG, Grossberg AJ, Molkentine J, Estrada DJ, Gross PS, Darpolor JK, Raj P, Vermeer DW, Vermeer P, Taniguchi C, Dantzer R. Elucidating the mechanisms of post-treatment cancer-related fatigue using a preclinical model [abstract]. Psychoneuroimmunology Research Society (PNIRS) 25th Annual Scientific Meeting, Miama Beach FL, Jun 6-9, 2018. Brain Behav Immun 75(Supplement), 2018. e-Pub 2018.
Klinedinst BS, Collazo-Martinez A, Dantzer R, Willette AA. Kynurenine pathway metabolites are longitudinally related to brain atrophy, cognitive decline, and negative affect across the Alzheimer's disease spectrum [abstract]. Psychoneuroimmunology Research Society (PNIRS) 25th Annual Scientific Meeting, Miama Beach FL, Jun 6-9, 2018. Brain Behav Immun 75(Supplement), 2018. e-Pub 2018.
Laumet GO, Edralin JD, Dantzer R, Heijnen CJ, Kavelaars A. Educated CD8+ T cells prevent chemotherapy-induced peripheral neuropathy (CIPN) [abstract]. Society for Neuroscience 47th Annual Meeting, Washington DC, Nov 11-15, 2017, 2017. e-Pub 2017.
Kavelaars A, Laumet G, Edralin JD, Dantzer R, Heijnen CJ. T cells are necessary for resolution of inflammation-induced depression-like behavior vian an IL-10 dependent pathway [abstract]. Society for Neuroscience 47th Annual Meeting, Washington DC, Nov 11-15, 2017, 2017. e-Pub 2017.
Grossberg A, Vichaya EG, Christian DL, Molkentine JM, Vermeer DW, Vermeer P, Lee JH, Heijnen CJ, Kavelaars A, Dantzer R. Tumor-associated fatigue develops independently of inflammation [abstract]. Psychoneuroimmunology Research Society (PNIRS) 24th Annual Scientific Meeting, Galveston TX, Jun 7-10, 2017. Brain Behav Immun 65(Supplement), 2017. e-Pub 2017.
Grossberg A, Zhang D, Zhou W, Weng CC, Gross PS, Vichaya EG, Dantzer R, Grosshans DR. The roles of neuroinflammation and orexin signaling in brain radiation-induced fatigue [abstract]. American Society for Radiation Oncology (ASTRO) 59th Annual Meeting, San Diego CA, Sep 24-27, 2017. Int J Radiat Oncol Biol Phys 99(2 Supplement 1):E592-3, 2017. e-Pub 2017.
Webb J, Dantzer R, Willette A. Neuroinflammation, depression and Alsheimer's Disease: insights from the kynurenine pathway [abstract]. Psychoneuroimmunology Research Society (PNIRS) 24th Annual Scientific Meeting, Galveston TX, Jun 7-10, 2017. Brain Behav Immun 65(Supplement), 2017. e-Pub 2017.
Grossberg AJ, Vichaya EG, Zhang D, Zhou W, Weng CC, Gross PS, Dantzer R, Grosshans DR. The role of orexin in brain radiation-induced fatigue [abstract]. Psychoneuroimmunology Research Society (PNIRS) 24th Annual Scientific Meeting, Galveston TX, Jun 7-10, 2017. Brain Behav Immun 65(Supplement), 2017. e-Pub 2017.
Kappelmann N, Lewis G, Dantzer R, Jones P, Khandaker GM. Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions [abstract]. Psychoneuroimmunology Research Society (PNIRS) 24th Annual Scientific Meeting, Galveston TX, Jun 7-10, 2017. Brain Behav Immun 65(Supplement), 2017. e-Pub 2017.
Lacourt TE, Vichaya E, Escalante C, Manzullo E, Gunn B, Heijnen C, Dantzer R. A new perspective on cancer-related fatigue: negative affectivity, depression, and inflammation leading to increased effort expenditure [abstract]. Psychoneuroimmunology Research Society (PNIRS) 24th Annual Scientific Meeting, Galveston TX, Jun 7-10, 2017. Brain Behav Immun 65(Supplement), 2017. e-Pub 2017.
Laumet G, Dantzer R, Edralin JD, Heijnen CJ, Kavelaars A. T cells are necessary for resolution of inflammation-induced depression-like behavior [abstract]. Psychoneuroimmunology Research Society (PNIRS) 24th Annual Scientific Meeting, Galveston TX, Jun 7-10, 2017. Brain Behav Immun 65(Supplement), 2017. e-Pub 2017.
Vichaya EG, Laumet GO, Christian DL, Grossberg AJ, Estrada DJ, Heijnen CJ, Kavelaars A, Dantzer R. Inflammation alters motivational processes in mice independently of its ability to activate indoleamine 2,3-dioxygenase [abstract]. Psychoneuroimmunology Research Society (PNIRS) 24th Annual Scientific Meeting, Galveston TX, Jun 7-10, 2017. Brain Behav Immun 65(Supplement), 2017. e-Pub 2017.
Laumet G, Edralin JD, Dantzer R, Heijnen CJ, Kavelaars A. Educated CD8+ T cells prevent chemotherapy-induced peripheral neuropathy (CIPN) [abstract]. Texas Pain Research Consortium Second Biennial Pain Research Conference, Galveston TX, Aug 24, 2017, 8/2017, 2017. e-Pub 2017.
Lacourt TE, Vichaya E, Escalante C, Manzullo E, Gunn B, Heijnen C, Dantzer R. A new perspective on cancer-related fatigue: negative affectivity and inflammation leading to increased effort expenditure [abstract]. Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) 2017 Annual Meeting, Washington DC, Jun 22-24, 2017. Support Care Cancer 25(Suppl 2):S114-5, 2017. e-Pub 2017.
Lacourt TE, Vichaya E, Escalante C, Manzullo E, Gunn B, Heijnen C, Dantzer R. A new perspective on cancer-related fatigue: negative affectivity and inflammation leading to increased effort expenditure [abstract]. Division of Internal Medicine 2017 Research Retreat, The University of Texas MD Anderson Cancer Center, Houston TX, May 11-12, 2017, 2017. e-Pub 2017.
Grossberg A, Vichaya EG, Zhang D, Zhou W, Weng CC, Gross PS, Dantzer R, Grosshans DR. The role of orexin in brain radiation-induced fatigue [abstract]. Division of Internal Medicine 2017 Research Retreat, The University of Texas MD Anderson Cancer Center, Houston TX, May 11-12, 2017, 2017. e-Pub 2017.
Grossberg A, Vichaya EG, Christian DL, Molkentine JM, Vermeer DW, Vermeer P, Lee JH, Heijnen CJ, Kavelaars A, Dantzer R. Tumor-associated fatigue develops independently of inflammation [abstract]. Division of Internal Medicine 2017 Research Retreat, The University of Texas MD Anderson Cancer Center, Houston TX, May 11-12, 2017, 2017. e-Pub 2017.
Vichaya EG, Laumet GO, Christian DL, Heijnen CJ, Kavelaars A, Dantzer R. Inflammation alters motivational processes in mice independently of its ability to activate the kynurenine metabolism pathway [abstract]. Division of Internal Medicine 2017 Research Retreat, The University of Texas MD Anderson Cancer Center, Houston TX, May 11-12, 2017, 2017. e-Pub 2017.
Laumet GO, Dantzer R, Edralin JD, Krukowski K, Heijnen CJ, Kavelaars A. Resolution of chemotherapy-induced neuropathic pain: a key role for CD8+ T lymphocytes [abstract]. Gulf Coast Consortium for Translational Pain Research 7th Annual Symposium, Houston TX, Apr 7, 2017, 2017. e-Pub 2017.
Konsman J, Chaskiel L, Dantzer R. Low grade colitis sensitizes sickness response to lipopolysaccharide in BALB/c mice [abstract]. Society for Neuroscience 46th Annual Meeting, San Diego CA, Nov 12-16, 2016, 2016. e-Pub 2016.
Laumet G, Dantzer R, Heijnen CJ, Kavelaars A. Evidence for dissociation between spontaneous pain and depression-like behavior in neuropathic pain models [abstract]. Psychoneuroimmunology Research Society (PNIRS) 23rd Annual Scientific Meeting, Brighton UK, Jun 8-11, 2016. Brain Behav Immun 57(Supplement):e11, 2016. e-Pub 2016.
Cho HJ, Savitz J, Dantzer R, Teague TK, Drevets WC, Irwin MR. Sleep disturbance and kynurenine metabolism in a group of currently depressed, previously depressed, and never depressed subjects [abstract]. Psychoneuroimmunology Research Society (PNIRS) 23rd Annual Scientific Meeting, Brighton UK, Jun 8-11, 2016. Brain Behav Immun 57(Supplement):e14, 2016. e-Pub 2016.
Grossberg A, Vichaya E, Christian D, Molkentine J, Vermeer DW, Heijnen C, Kavelaars A, Lee JH, Sood AK, Dantzer R. The role of neuroinflammation in tumor-induced fatigue [abstract]. American Society for Radiation Oncology (ASTRO) 58th Annual Meeting, Boston MA, Sep 25-28, 2016. Int J Radiat Oncol Biol Phys 96(2 Supplement):E562, 2016. e-Pub 2016.
Vichaya EG, Vermeer DW, Christian DL, Molkentine JM, Mason KA, Kavelaars A, Heijnen CJ, Lee JH, Dantzer R. Tumor-induced inflammation mediates behavioral deficits in a murine model of head and neck cancer [abstract]. Psychoneuroimmunology Research Society (PNIRS) 23rd Annual Scientific Meeting, Brighton UK, Jun 8-11, 2016. Brain Behav Immun 57(Supplement):e12, 2016. e-Pub 2016.
Lacourt TE, Vichaya E, Escalante C, Ellen M, Gunn B, Heijnen C, Dantzer R. Deconstructing cancer-related fatigue: A role for motivational deficits [abstract]. Psychoneuroimmunology Research Society (PNIRS) 23rd Annual Scientific Meeting, Brighton UK, Jun 8-11, 2016. Brain Behav Immun 57(Supplement):e21-2, 2016. e-Pub 2016.
Laumet G, Dantzer R, Krukowski K, Heijnen CJ, Kavelaars A. T lymphocytes are required for resolution of inflammatory pain and depression-like behavior [abstract]. Psychoneuroimmunology Research Society (PNIRS) 23rd Annual Scientific Meeting, Brighton UK, Jun 8-11, 2016. Brain Behav Immun 57(Supplement):e5-6, 2016. e-Pub 2016.
Walker AK, Danysh BP, Christian DL, Remus JL, Hofmann M, Dantzer R. Rapamycin inhibits antidepressant effects of leucine in lipopolysaccharide-treated mice [abstract]. Psychoneuroimmunology Research Society (PNIRS) 23rd Annual Scientific Meeting, Brighton UK, Jun 8-11, 2016. Brain Behav Immun 57(Supplement):e12-3, 2016. e-Pub 2016.
Vichaya EG, Christian DL, Dantzer R. Activation of indoleamine 2,3 dioxygenase does not mediate inflammation-induced reductions in incentive motivation [abstract]. Psychoneuroimmunology Research Society (PNIRS) 23rd Annual Scientific Meeting, Brighton UK, Jun 8-11, 2016. Brain Behav Immun 57(Supplement):e12, 2016. e-Pub 2016.
Vichaya EG, Vermeer DW, Molkentine JM, Christian DL, Kavelaars A, Heijnen CJ, Mason KA, Lee JH, Dantzer R. Sickness behavior induced by the tumor in a murine model of head and neck cancer is mediated by inflammation [abstract]. Division of Internal Medicine Research Retreat, The University of Texas MD Anderson Cancer Center, Houston TX, Apr 28-29, 2016, 2016. e-Pub 2016.
Christian DL, Vichaya EG, Dantzer R. Exploring the role of indoleamine 2,3 dioxygenase in inflammation-induced reductions in incentive motivation [abstract]. Division of Internal Medicine Research Retreat, The University of Texas MD Anderson Cancer Center, Houston TX, Apr 28-29, 2016, 2016. e-Pub 2016.
Laumet G, Krukowski K, Dantzer R, Heijnen CJ, Kavelaars A. T lymphocytes are required for resolution of pain [abstract]. Gulf Coast Consortium for Translational Pain Research 6th Annual Symposium, Houston TX, Apr 8, 2016, 2016. e-Pub 2016.
Laumet G, Dantzer R, Heijnen CJ, Kavelaars A. Experience of chronic pain does not cause depressive-like behaviors in neuropathic pain models [abstract]. Diagnosis, Mechanisms, and Management of Cancer Treatment-Induced Neurotoxicities, The University of Texas MD Anderson Cancer Center, Houston TX, Jan 22-23, 2016, 2016. e-Pub 2016.
Vichaya EG, Vermeer DW, Molkentine JM, Christian DL, Kavelaars A, Heijnen CJ, Mason KA, Lee JH, Dantzer R. Sickness behavior induced by the tumor in a murine model of head and neck cancer is mediated by inflammation [abstract]. Diagnosis, Mechanisms, and Management of Cancer Treatment-Induced Neurotoxicities, The University of Texas MD Anderson Cancer Center, Houston TX, Jan 22-23, 2016, 2016. e-Pub 2016.
Laumet G, Krukowski K, Walker AK, Dantzer R, Heijnen CJ, Kavelaars A. T lymphocytes promote recovery from comorbid pain and depression [abstract]. Diagnosis, Mechanisms, and Management of Cancer Treatment-Induced Neurotoxicities, The University of Texas MD Anderson Cancer Center, Houston TX, Jan 22-23, 2016, 2016. e-Pub 2016.
Christian DL, Vichaya EG, Dantzer R. Exploring the role of indoleamine 2,3 dioxygenase in inflammation-induced reductions in incentive motivation [abstract]. Diagnosis, Mechanisms, and Management of Cancer Treatment-Induced Neurotoxicities, The University of Texas MD Anderson Cancer Center, Houston TX, Jan 22-23, 2016, 2016. e-Pub 2016.
Lacourt TE, Escalante C, Manzullo E, Gunn B, Vichaya E, Cleeland CS, Heijnen CJ, Dantzer R. Deconstructing cancer-related fatigue: deficit in incentive motivation as a component of fatigue [abstract]. Diagnosis, Mechanisms, and Management of Cancer Treatment-Induced Neurotoxicities, The University of Texas MD Anderson Cancer Center, Houston TX, Jan 22-23, 2016, 2016. e-Pub 2016.
Vichaya EG, Christian D, Hunt S, Dantzer R. Preclinical characterization of inflammation-induced motivational deficits [abstract]. American College of Neuropsychopharmacology (ACNP) 54th Annual Meeting, Hollywood FL, Dec 6-10, 2015. Neuropsychopharmacology 40(S1):S35-6, 2015. e-Pub 2015.
Walker AK, Wing E, Vichaya E, Banks WA, Dantzer R. Inhibition of blood-to-brain kyneureine transport blocks lipopolysaccharide-induced depression-like behavior [abstract]. Psychoneuroimmunology Research Society (PNIRS) 22nd Annual Meeting, Seattle WA, Jun 3-6, 2015. Brain Behav Immun 49(Supplement), 2015. e-Pub 2015.
Walker AK, Vichaya EG, Wing E, Banks WA, Dantzer R. Leucine blocks lipopolysaccharide-induced dpression-like behavior by interfering with kyneurenine influx into the brain [abstract]. Psychoneuroimmunology Research Society (PNIRS) 22nd Annual Meeting, Seattle WA, Jun 3-6, 2015. Brain Behav Immun 49(Supplement):e36, 2015. e-Pub 2015.
Vichaya EG, Molkentine JM, Vermeer DW, Walker AK, Feng R, Holder G, Luu KV, Mason RM, Saligan L, Heijnen CJ, Kavelaars A, Mason KA, Lee JH, Dantzer R. Chemoradiation abrogates inflammation, induces sickness behavior, activates hypoxia signaling pathways, and causes mitochondrial dysfunction in a syngenic murine model of head and neck cancer [abstract]. Psychoneuroimmunology Research Society (PNIRS) 22nd Annual Meeting, Seattle WA, Jun 3-6, 2015. Brain Behav Immun 49(Supplement):e35-6, 2015. e-Pub 2015.
Laumet G, Krukowski K, Walker AK, Dantzer R, Heijnen CJ, Kavelaars A. T lymphocytes promote recovery from inflammation-induced comorbid pain and depression [abstract]. Society for Neuroscience 45th Annual Meeting, Chicago IL, October 17-21, 2015, 2015. e-Pub 2015.
Vichaya EG, Molkentine JM, Vermeer DW, Walker AK, Feng R, Holder G, Luu KV, Mason RM, Saligan L, Heijnen CJ, Kavelaars A, Mason KA, Lee JH, Dantzer R. Chemoradiation abrogates inflammation, induces sickness behavior, activates hypoxia signaling pathways, and causes mitochondrial dysfunction in a syngenic murine model of head and neck cancer [abstract]. Division of Internal Medicine Research Retreat, The University of Texas MD Anderson Cancer Center, Houston TX, May 14-15, 2015, 2015. e-Pub 2015.
Laumet G, Krukowski K, Walker AK, Dantzer R, Heijnen CJ, Kavelaars A. Could T lymphocytes promote recovery of inflammation-induced comorbid pain and depression? [abstract]. Gulf Coast Consortium for Translational Pain Research 2015 Research Colloquium, Houston TX, Apr 16, 2015, 2015. e-Pub 2015.
Lacourt TE, Gunn GB, Vichaya EG, Cleeland CS, Heijnen CJ, Dantzer R. Deconstructing cancer-related fatigue using behavioral measures [abstract]. MD Anderson 2015 Cancer Survivorship Research Symposium, Houston TX, Apr 18, 2015, 2015. e-Pub 2015.
Krukowski K, Eijkelkamp N, Wang H, M-Y Q, Dantzer R, Heijnen CJ, Kavelaars A. CD8+ T cells are important for recovery from chemotherapy-induced neuropathy in mice [abstract]. Psychoneuroimmunology Research Society (PNIRS) 21st Annual Meeting, Philadephia PA, May 28-31, 2014. Brain Behav Immun 40(Supplement):e31, 2014. e-Pub 2014.
Vichaya EG, Vermeer DW, Kavelaars A, Lee JH, Dantzer R. Can indoleamine 2,3-dioxygenase (IDO) be targeted to improve tumor clearance as well as attenuate cancer-related symptoms? [abstract]. Psychoneuroimmunology Research Society (PNIRS) 21st Annual Meeting, Philadephia PA, May 28-31, 2014. Brain Behav Immun 40(Supplement):e26, 2014. e-Pub 2014.
Vichaya EG, Hunt SC, Dantzer R. Lipopolysaccharide reduces incentive motivation while boosting preference for high reward in mice [abstract]. Psychoneuroimmunology Research Society (PNIRS) 21st Annual Meeting, Philadephia PA, May 28-31, 2014. Brain Behav Immun 40(Supplement):e26, 2014. e-Pub 2014.
Walker AK, Wing E, Banks WA, Dantzer R. Targeting the kynurenine blood-to-brain transport system to treat inflammation-induced fatigue and depression: proof of principle studies with leucine [abstract]. Psychoneuroimmunology Research Society (PNIRS) 21st Annual Meeting, Philadephia PA, May 28-31, 2014. Brain Behav Immun 40(Supplement):e24-5, 2014. e-Pub 2014.
Walker AK, Luu KV, Radwan A, Wing E, Banks WA, Dantzer R. Targeting kynurenine transport systems to treat inflammation-induced depression [abstract]. Division of Internal Medicine Research Retreat, The University of Texas MD Anderson Cancer Center, Houston TX, May 1-2, 2014, 2014. e-Pub 2014.
Zhou W, Dantzer R, Budac DP, Lee AW, O'Connor JC, Heijnen CJ, Kavelaars A. Peripheral IDO1 and neuronal KMO in comorbid neuropathic pain and depression-like behavior in mice [abstract]. Gulf Coast Consortium for Translational Pain Research Fifth Annual Symposium, Houston TX, Apr 4, 2014, 2014. e-Pub 2014.
Vichaya EG, Vermeer DW, Molkentine JM, Walker AK, Luu KV, Mao-Ying QL, Huo XJ, Mason KA, Lee JH, Kavelaars A, Dantzer R. Evaluating the role of neuroinflammation in head and neck cancer-related symptoms [abstract]. MD Anderson 2014 Cancer Survivorship Research Symposium, Houston TX, Jan 30, 2014, 2014. e-Pub 2014.
Vichaya EG, Hunt SC, Dantzer R. Inflammation and incentive motivation: lipopolysaccharide decreases effort but increases preference for a highly preferred reward in an effort-related choice task in mice [abstract]. MD Anderson 2014 Cancer Survivorship Research Symposium, Houston TX, Jan 30, 2014, 2014. e-Pub 2014.
Lacourt TE, Vichaya EG, Cleeland CS, Heijnen CJ, Dantzer R. Deconstructing cancer-related fatigue [abstract]. MD Anderson 2014 Cancer Survivorship Research Symposium, Houston TX, Jan 30, 2014, 2014. e-Pub 2014.
Walker AK, Luu KV, Radwan A, Wing E, Banks WA, Dantzer R. Targeting tryptophan transport systems to treat inflammation-induced depression [abstract]. MD Anderson 2014 Cancer Survivorship Research Symposium, Houston TX, Jan 30, 2014, 2014. e-Pub 2014.
Walker AK, Budac DP, Bisulco S, Lee AW, Hsieh J, Smith RA, Beenders B, Kelley KW, Dantzer R. Inflammation-induced depressive-like behavior is abrogated by blockade of the NMDA glutamate receptor with ketamine in C57BL/6J mice [abstract]. MD Anderson 2014 Cancer Survivorship Research Symposium, Houston TX, Jan 30, 2014, 2014. e-Pub 2014.
Cleeland CS, Dantzer R, Sloan JA, Verstovsek S, Emanuel RM, Geyer HL, Mesa RM. Cytokine profile changes in 309 myelofibrosis patients: comparison of JAK1/JAK2 inhibitor therapy vs. placebo - correlative analysis from the COMFORT-1 Trial [abstract]. American Society of Hematology 55th Annual Meeting and Exposition, New Orleans LA, Dec 7-10, 2013. Blood 122(21), 2013. e-Pub 2013.
Zhou W, M-Y Q, Heijnen CJ, Dantzer R, Kavelaars A. Indoleamine 2,3 dioxydenase (IDO1) is a key regulator of depressive-like behavior but not of mechanical hyperalgesia in the spared nerve injury model of neuropathic pain [abstract]. Psychoneuroimmunology Research Society (PNIRS) 20th Annual Meeting, Stockholm, Sweden, Jun 5-8, 2013. Brain Behav Immun 32(Suppl):e34, 2013. e-Pub 2013.
Wang XS, Dantzer R, Fuchs D, Eng C, Jing KY, Sailors M, Cleeland CS. Fatigue, affective symptom burden and altered tryptophan and phenylalanine metabolism in colorectal cancer patients undergoing chemotherapy [abstract]. Psychoneuroimmunology Research Society (PNIRS) 20th Annual Meeting, Stockholm, Sweden, Jun 5-8, 2013. Brain Behav Immun 32(Suppl):e36, 2013. e-Pub 2013.
Krukowski K, Eijkelkamp N, Wang H, M-Y Q, Dantzer R, Heijnen CJ, Kavelaars A. Contribution of peripheral immune cells to chemotherapy-induced neuropathy [abstract]. Psychoneuroimmunology Research Society (PNIRS) 20th Annual Meeting, Stockholm, Sweden, Jun 5-8, 2013. Brain Behav Immun 32(Suppl):e25-6, 2013. e-Pub 2013.
Huo X, M-Y Q, Zhou W, Dantzer R, Heijnen CJ, Kavelaars A. Intrathecal administration of microRNA-124 alleviates both neuropathic pain and depression-like behavior in mice [abstract]. Psychoneuroimmunology Research Society (PNIRS) 20th Annual Meeting, Stockholm, Sweden, Jun 5-8, 2013. Brain Behav Immun 32(Suppl):e19, 2013. e-Pub 2013.
Walker AK, Budac DP, Bisulco S, Lee AW, Smith RA, Beenders B, Kelley KW, Dantzer R. Ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL/6J mice by increasing AMPA receptor-mediated glutamatergic neurotranmission over NMDA receptor-mediated neurotransmission [abstract]. Psychoneuroimmunology Research Society (PNIRS) 20th Annual Meeting, Stockholm, Sweden, Jun 5-8, 2013. Brain Behav Immun 32(Suppl):e16, 2013. e-Pub 2013.
Vichaya EG, Vermeer DW, Molkentine JM, Mao-Ying Q, Huo X, Mason KA, Lee JH, Kavelaars A, Dantzer R. Evaluating the role of neuroinflammation in head and neck cancer-related symptoms [abstract]. Psychoneuroimmunology Research Society (PNIRS) 20th Annual Meeting, Stockholm, Sweden, Jun 5-8, 2013. Brain Behav Immun 32(Suppl):e35-6, 2013. e-Pub 2013.
Pryce CR, Pariante CM, Eisel U, Dantzer R. Cytokines, inflammation and affective disorders: human evidence and animal models [abstract]. International Society of Psychoneuroendocrinology (ISPNE) 43rd Annual Meeting, Leiden, The Netherlands, Aug 20-22, 2013, 2013, 2013. e-Pub 2013.
Dantzer R, Vichaya EG, Vermeer DW, Molkentine JM, Mao-Ying QL, Huo XJ, Mason KA, Lee JH, Kavelaars A. Evaluating the role of neuroinflammation in cancer-related symptoms [abstract]. International Society of Psychoneuroendocrinology (ISPNE) 43rd Annual Meeting, Symposium on Neuroimmunology and Psychiatry, Leiden, The Netherlands, Aug 20-22, 2013, 2013, 2013. e-Pub 2013.
Huo XJ, Mao-Ying QL, Zhou W, Dantzer R, Heijnen CJ, Kavelaars A. Intrathecal administration of microRNA-124 alleviates both neuropathic pain and depressive-like behavior in mice [abstract]. Division of Internal Medicine Research Retreat, The University of Texas MD Anderson Cancer Center, Houston TX, Jun 6-7, 2013, 2013. e-Pub 2013.
Walker AK, Budac DP, Bisulco S, Lee AW, Hsieh J, Smith RA, Beenders B, Kelley KW, Dantzer R. Ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL/6J mice by enhancing AMPA receptor-mediated glutamatergic neurotranmission over NMDA receptor-mediated neurotransmission [abstract]. Division of Internal Medicine Research Retreat, The University of Texas MD Anderson Cancer Center, Houston TX, Jun 6-7, 2013, 2013. e-Pub 2013.
Krukowski K, Eijkelkamp N, Wang H, M-Y Q, Dantzer R, Heijnen CJ, Kavelaars A. Contribution of peripheral immune cells to chemotherapy-induced neuropathy [abstract]. Division of Internal Medicine Research Retreat, The University of Texas MD Anderson Cancer Center, Houston TX, Jun 6-7, 2013, 2013. e-Pub 2013.
Vichaya EG, Vermeer DW, Molkentine JM, Mao-Ying QL, Huo XJ, Mason KA, Lee JH, Kavelaars A, Dantzer R. Evaluating the role of neuroinflammation in head and neck cancer-related symptoms [abstract]. Division of Internal Medicine Research Retreat, The University of Texas MD Anderson Cancer Center, Houston TX, Jun 6-7, 2013, 2013. e-Pub 2013.
Mao-Ying QL, Zhou W, Dantzer R, Heijnen CJ, Kavelaars A. Low GRK2 prolongs pain but not depressive-like behavior in response to peripheral inflammation in mice [abstract]. Division of Internal Medicine Research Retreat, The University of Texas MD Anderson Cancer Center, Houston TX, Jun 6-7, 2013, 2013. e-Pub 2013.
Zhou W, Mao-Ying QL, Heijnen CJ, Dantzer R, Kavelaars A. Indoleamine 2,3 dioxydenase (IDO1) is a key regulator of depressive-like behavior but not of mechanical hyperalgesia in the spared nerve injury model of neuropathic pain [abstract]. Division of Internal Medicine Research Retreat, The University of Texas MD Anderson Cancer Center, Houston TX, Jun 6-7, 2013, 2013. e-Pub 2013.
Zhou W, Dantzer R, Kelley KW, Kavelaars A. Comorbid chronic pain and depression: A search for common neuroimmune mechanisms [abstract]. Psychoneuroimmunology Research Society 19th Annual Meeting, San Diego CA, Jun 7-9, 2012. Brain Behav Immun 26(Suppl 1):S45, 2012. e-Pub 2012.
Corona AW, Skendelas JP, Norden DM, Huang Y, O'Connor JC, Lawson M, Dantzer R, Kelley KW, Godbout JP. Indolamine-2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX3 CR1)-deficient mice [abstract]. Psychoneuroimmunology Research Society 19th Annual Meeting, San Diego CA, Jun 7-9, 2012. Brain Behav Immun 26(Suppl 1):S26, 2012. e-Pub 2012.
Martin SA, Johnson SJ, Greene RM, Dantzer R, Kelley KW, Woods JA. The effects of voluntary-wheel exercise in LPS-induced sickness behavior in aged mice [abstract]. Psychoneuroimmunology Research Society 19th Annual Meeting, San Diego CA, Jun 7-9, 2012. Brain Behav Immun 26(Suppl 1):S36-7, 2012. e-Pub 2012.
McCusker RH, Park S, Lawson MA, Dantzer R, Kelley KW. Insulin-like growth factor (IGF)-I interaction with lipopolysaccharide (LPS) on organotypic hippocampal slice cultures (OHSCs) [abstract]. Psychoneuroimmunology Research Society 19th Annual Meeting, San Diego CA, Jun 7-9, 2012. Brain Behav Immun 26(Suppl 1):S24-5, 2012. e-Pub 2012.
Wang XS, Shi Q, Shah N, Dantzer R, Johnson V, Reuben J, Cohen E, Ilagan V, Williams L, Cleeland C. Association between serum inflammatory markers and autologous stem cell transplant-induced sickness symptoms in patients with multiple myeloma [abstract]. Psychoneuroimmunology Research Society 19th Annual Meeting, San Diego CA, Jun 7-9, 2012. Brain Behav Immun, 2012. e-Pub 2012.
Walker AK, Smith RA, Beenders B, Kelley KW, Dantzer R. Ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL/6J mice by antagonizing the activation of NMDA receptors [abstract]. Psychoneuroimmunology Research Society 19th Annual Meeting, San Diego CA, Jun 7-9, 2012. Brain Behav Immun 26(Suppl 1):S7, 2012. e-Pub 2012.
Walker AK, Smith RA, Beenders B, Kelley KW, Dantzer R. Ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL/6J mice by antagonizing the activation of NMDA receptors [abstract]. The University of Texas MD Anderson Cancer Center, Division of Internal Medicine Research Retreat, Houston TX, May 24, 2012, 2012. e-Pub 2012.

Book Chapters

Dantzer R. Role of the kynurenine metabolism pathway in inflammation-induced depression: preclinical approaches. In: Curr Top Behav Neurosci. Springer International Publishing, 117-138, 2017.
Dantzer R. Psychiatric disorders and inflammation. In: Inflammation – From Molecular and Cellular Mechanisms to the Clinic. Wiley, 2017.
Dantzer R. Behavior: overview. In: Stress: Concepts, Cognition, Emotion, and Behavior. Elsevier Academic Press, 57-62, 2016.
McCusker RM, Kavelaars AM, Heijnen CJ, Dantzer R, Kelley KW. Depression, inflammation and tryptophan metabolism. In: The Wiley-Blackwell Handbook of Psychoneuroimmunology. John Wiley & Sons, Ltd, 2014.
Dantzer R, Kelley KW. Neuroimmunological crosstalk in critical illness. In: Brain Disorders in Critical Illness: Mechanisms, Diagnosis, and Treatment. Cambridge University Press, 162-73, 2013.
Walker AK, Dantzer R, Kelley KW. Mood disorders and immunity. In: Neural-Immune Interactions in Brain Function and Alcohol Rleated Disorders. Springer US, 167-209, 2013.
Dantzer R, Kelley KW. Psychoneuroimmune phenomena: neuroimmune interactions. In: Neuroscience in the 21st Century: From Basic to Clinical. Springer, 527-554, 2013.
O’Connor JC, McCusker RH, Johnson RW, Dantzer R, Kelley KW. Antibiotics, inflammation and animal growth: cytokine-induced hormone resistance. In: Encyclopedia of Animal Science. 2nd ed. Taylor & Francis, 2011.
Dantzer R, Kelley KW. From inflammation to sickness and depression: the cytokine connection. In: Cancer Symptom Science: Measurement, Mechanisms and Management. Cambridge University Press, 100-14, 2011.
Kelley KW, Aubert A, Dantzer R. Inflammation and behavior. In: Ecoimmunology. Oxford University Press, 383-412, 2011.
Dantzer R. Que faire du comportement dans les sciences du comportement?. In: Penser le Comportement Animal. Quae, 197-209, 2010.
Dantzer R. Psychoneuroendocrinology of stress. In: Encyclopedia of Behavioral Neuroscience. Academic Press, 126-31, 2010.
Dantzer R, Kelley KW. Cytokines. In: Oxford Companion to Emotion and the Affective Sciences. Oxford University Press, 108-9, 2009.
Dimsdale JE, Dantzer R. A biological substrate for somatoform disorders. In: Somatic Presentations of Mental Disorders. Refining the Research Agenda for DSM-V. American Psychiatric Association, 63-74, 2009.
Kelley KW, Dantzer R. Immunity and emotion. In: Oxford Companion to Emotion and the Affective Sciences. Oxford University Press, 211-4, 2009.
Dantzer R, O’Connor JC, Castanon N, Lestage J, Kelley KW. Cytokines and depression: experimental evidence and intermediate mechanisms. In: Understanding Depression: A Translational Approach. Oxford University Press, 123-38, 2009.
Dantzer R, Kelley KW. Psychoneuroimmunology. In: Oxford Companion to Emotion and the Affective Sciences. Oxford University Press, 320-2, 2009.
Dantzer R. Neuroendocrine system. In: Oxford Companion to Emotion and the Affective Sciences. Oxford University Press, 279-80, 2009.
Dantzer R. Psychoneuroendocrinology. In: Oxford Companion to Emotion and the Affective Sciences. Oxford University Press, 318-20, 2009.
Dantzer R. Neurotransmitters. In: Oxford Companion to Emotion and the Affective Sciences. Oxford University Press, 281-2, 2009.
Dantzer R. Neuropeptides. In: Oxford Companion to Emotion and the Affective Sciences. Oxford University Press, 280-1, 2009.
Capuron L, Dantzer R. Inflammation and mood. In: Oxford Companion to Emotion and the Affective Sciences. Oxford University Press, 218, 2009.
Dantzer R, Aubert A, Bluthé RM, Gheusi G, Cremona S, Layé S, Konsman JP, Parnet P, Kelley KW. Inflammation, sickness behaviour and depression. In: Depression and Physical Illness. Cambridge University Press, 265-79, 2007.
Dantzer R. Behavior: overview. In: Encyclopedia of Stress. 2nd ed. Academic Press, 307-9, 2007.
Dantzer R. Psychoneuroimmunology. In: Encyclopedia of Stress. 2nd ed. Academic Press, 284-7, 2007.
McCusker RH, Strle K, Broussard SR, Dantzer R, Bluthe RM, Kelley KW. Crosstalk between insulin-like growth factors and proinflammatory cytokines. In: Psychoneuroimmunology. 4th ed. Elsevier, 171-92, 2006.
Dantzer R. Expression and actions of cytokines in the brain: mechanisms and pathophysiological implications. In: Psychoneuroimmunology. 4th ed. Elsevier, 271-80, 2006.
Dantzer R. Cytokines in the brain: an introduction. In: Psychoneuroimmunology. 4th ed. Elsevier, 267-70, 2006.
Layé S, Dantzer R. Polyunsaturated fatty acids and neuroinflammation. In: Nutrients, Stress and Medical Disorders. Humana Press, 353-75, 2006.
Dantzer R, Bluthé RM, Castanon N, Kelley KW, Konsman JP, Layé S, Lestage J, Parnet P. Cytokines, sickness behavior, and depression. In: Psychoneuroimmunology. 4th ed. Elsevier, 281-318, 2006.
Dantzer R, Konsman JP, Parnet P. Mechanisms of cytokine-induced sickness behavior. In: Neuroimmunoendocrinology. Marcel Dekker, 707-20, 2004.
Konsman JP, Dantzer R. Neuroimmunology of eating disorders. In: Biological Psychiatry. Wiley, 1149-58, 2002.
Dantzer R. Emotional states and the immune system. In: Frontiers of Life. Academic Press, 79-94, 2002.
Dantzer R. Cytokines and sickness behavior. In: Cytokines and Mental Health. Kluwer Academic/Plenum, 129-46, 2002.
Dantzer R. Personnalité et maladie: l'apport de la psychoneuroimmunologie. In: Personnalité et Maladie. Dunod, 261-81, 2001.
Dantzer R. Can we understand the brain and coping without considering the immune system?. In: Coping with Challenge: Welfare in Animals including Humans: Dahlem Workshop Report. Dahlem University Press, 101-10, 2001.
Arkins S, Johnson RW, Minshall C, Dantzer R, Kelley KW. Immunophysiology: The interaction of hormones, lymphohemopoietic cytokines and the neuroimmune axis. In: Coping with the Environment: Neural and Endocrine Mechanisms. American Physiological Society/Oxford University Press, 469-95, 2001.
Dantzer R, Bluthé RM, Castanon N, Chauvet N, Capuron L, Goodall G, Kelley KW, Konsman JP, Layé S, Parnet P, Pousset F. Cytokine effects on behavior. In: Psychoneuroimmunology. 3rd ed. Academic Press, 703-27, 2001.
Venters HD, Dantzer R, Freund GG, Broussard SR, Kelley KW. Growth hormone and insulin-like growth factor as cytokines in the immune system. In: Psychoneuroimmunology. 3rd ed. Academic Press, 339-62, 2001.
Dantzer R. La dimension biologique du bien-être animal. In: Les Animaux d'Élevage Ont-ils Droit au Bien-être?. INRA, 2001.
Dantzer R, Gawlick U, Heusmann G, Kelley KW. Immunology. In: Encyclopedia of Psychology. American Psychological Association, 2000.
Dantzer R. Behaviior: overview. In: Encyclopedia of Stress. Academic Press, 296-9, 2000.
Dantzer R. Psychoneuroimmunology. In: Encyclopedia of Stress. Academic Press, 294-8, 2000.
Dantzer R, Aubert A, Bluthé RM, Konsman JP, Layé S, Parnet P, Kelley KW. Sickness behaviour: a neuroimmune-based response to infectious disease. In: Neuro-immune Interactions in Neurologic and Psychiatric Disorders. Springer-Verlag, 169-84, 2000.
Aubert A, Dantzer R. Le comportement de maladie: aspects motivationnels et cognitifs (Sickness behaviour, motivational and cognitive aspects). In: Eléments d’Ethologie Cognitve. Hermès, 117-32, 1999.
Dantzer R, Aubert A, Bluthé RM, Gheusi G, Cremona S, Layé S, Konsman JP, Parnet P, Kelley KW. Mechanisms of the behavioural effects of cytokines. In: Cytokines, Stress and Depression. Kluwer Academic/Plenum, 83-105, 1999.
Dantzer R, Wollman EE, Vitkovic L, Yirmiya R. Cytokines, stress and depression: conclusions and perspectives. In: Cytokines, Stress and Depression. Kluwer Academic/Plenum, 317-29, 1999.
Dantzer R. Emozioni e sistema immunitario. In: Frontiere della Vita. Istituto Enciclopedia Italiana, 71-83, 1999.
Dantzer R. L’anhédonie: approches psychobiologiques (Psychobiological aspects of anhedonia). In: L’anhédonie. Le Non-Plaisir et la Psychopathologie. Masson, 89-95, 1999.
Dantzer R. Neuroimmune interactions and brain disorders. In: Interactive Monoaminergic Disorders. Editorial Sintesis, 147-56, 1998.
Dantzer R. Psychobiologie du trouble de l’adaptation avec anxiété (Psychobiological aspects of adaptation disorders with anxiety). In: Le Trouble de l’Adaptation avec Anxiété. Springer, 67-71, 1998.
Dantzer R. Sickness behavior: A neuroimmune based response to infectious disease. In: Psychoneuroimmunology: A Textbook. Plenum, 235-57, 1998.
Dantzer R, Layé S, Goujon E, Bluthé RM, Konsman JP, Parnet P, Kelley KW. Mechanisms of actions of cytokines on the central nervous system. Interaction with glucococorticoids. In: Steroid Hormones and the T-cell Cytokine Profile. Springer, 1-13, 1997.
Dantzer R. "Sickness behaviour": eine neuroimmunilogische Antwort auf Infektionskrankheiten. In: Psychoneuroimmunologie. Spektrum, 305-32, 1996.
Dantzer R, Le Neindre P. Le bien-être des animaux d'élevage (Welfare of farm animals). In: Le Livre de l'Année 1996. Larousse, 209-11, 1996.
Dantzer R, Bluthé RM, Aubert A, Goodall G, Bret-Dibat JL, Kent S, Goujon E, Layé S, Parnet P, Kelley KW. Cytokine actions on behavior. In: Cytokines in the Nervous System. RG Landes Company, 117-44, 1996.
Dantzer R, Mormède P. Psychoneuroimmunology of stress. In: Stress, the Immune System and Psychiatry. Wiley, 45-67, 1995.
Dantzer R. Stress. In: Encyclopaedia Universalis. Encyclopædia Britannica, Inc, 659-60, 1995.
Dantzer R, Satinoff E. La dynamique motivationnelle. In: Traité de Psychologie Expérimentale. Presses Universitaires de France, 45-80, 1994.
Dantzer R, Goodall G. Psychobiologie du stress (Psychobiology of stress). In: Introduction à la Psychologie de la Santé. Presses Universitaires de France, 1994.
Terlouw C, Kent S, Dantzer R, Monin G. L'hyperthermie induite par le stress: données préliminaires (Stress-induced hyperthermia: preliminary data). In: Comportement et Bien-Etre Animal. INRA, 191-201, 1994.
Kent S, Bluthé RM, Goodall G, Kelley KW, Dantzer R. Central nervous system control of sickness behavior. In: Brain Control of Responses to Trauma. Cambridge University Press, 152-82, 1994.
Kelley KW, Dantzer R. Growth hormone and IGF-1 in thymopoiesis. In: Molecular and Clinical Advances in Pituitary Disorders - 1993, Proceedings of the 3rd International Pituitary Congress. Endocrine Research and Education Inc, 93-7, 1993.
Dantzer R, Mittleman G. Functional consequences of behavioural stereotypy. In: Stereotypic Animal Behaviour: Fundamentals and Applications to Welfare. CAB, 147-72, 1993.
Kelley KW, Kent S, Dantzer R. Why sick animals don't grow: an immunological explanation. In: Growth of the Pig. CAB, 119-32, 1993.
Dantzer R. Coping with stress. In: Stress: From Synapse to Syndrome. Academic Press, 167-89, 1993.
Dantzer R, Bluthé RM, Kent S, Goodall G. Behavioral effects of cytokines: an insight into mechanisms of sickness behavior. In: Neurobiology of Cytokines. Academic Press, 130-50, 1993.
Dantzer R, Bluthé RM, Kent S, Kelley KW. Cytokines and sickness behavior. In: Psychoimmunology: CNS-Immune Interactions. CRC Press, 1-16, 1993.
Dantzer R. Neuroimmune basis of sickness behaviour. In: Proceedings of the International Congress on Applied Ethology. Humboldt University, 115-22, 1993.
Salaün MC, Dantzer R. Behaviour, stress and disease. In: Livestock Health and Welfare. Longman, 87-117, 1992.
Dantzer R, Bluthé RM, Kent S, Kelley KW. Cytokines and sickness behaviour. In: Interleukin-1 in the Brain. Pergamon, 135-51, 1992.
Koob GF, Lebrun C, Bluthé RM, Dantzer R, Dorsa DM, Le Moal M. Vasopressin and learning: peripheral and central mechanisms. In: Peripheral Signalling of the Brain: Neural-immune and Cognitive Function. Hogrefe and Huber, 351-63, 1991.
Dantzer R. La douleur: aspects comportementaux et psychologiques (Pain: behavioural and psychological aspects). In: Douleurs, du Neurone à l'Homme Souffrant. Eshel, 47-61, 1991.
Kelley KW, Dantzer R. Growth hormone and prolactin as natural antagonists of glucocorticoids in immunoregulation. In: Stress and Immunity. The Telford Press, 433-52, 1991.
Dantzer R. Stress and neuroscience. In: Applied Animal Behaviour: Past, Present and Future. UFAW, 118-9, 1991.
Mormède P, Dantzer R. Caractéristiques adaptatives des races porcines chinoises (Adaptative abilities of Chinese pigs). In: Symposium sur le Porc Chinois, 5-6 Juillet 1990. INRA, 155-65, 1990.
Kelley KW, Dantzer R. Neuroendocrine-immune interactions. In: Immunomodulation in Domestic Food Animals. Academic Press, 283-305, 1990.
Dantzer R. Activation, anxiété, dépendance d'état, emotion, frustration, james-lange (théorie de), médecine comportementale, nouveauté, souffrance, stéréotypie, tolérance comportementale (définitions). In: Dictionnaire de Psychologie. Presses Universitaires de France, 1990.
Dantzer R. The concept of social stress. In: Social Stress in Domestic Animals. Kluwer, 3-7, 1990.
Dantzer R, Neveu PJ, Kelley KW. Stress et réponse immune (Stress and immunity). In: Immunologie Animale. Flammarion, 397-405, 1990.
Dantzer R. Biobehavioral responses to stressors. In: Stress and Digestive Motility. John Libbey Eurotext, 23-9, 1989.
Dantzer R. La mémoire affective (Affective memory). In: La Mémoire. l'Harmattan, 79-85, 1989.
Dantzer R. Neuroendocrine correlates of control and coping. In: Stress, Personal Control and Health. Wiley, 277-94, 1989.
Dantzer R. Ethical aspects of the use of biotechnology for the control of growth and product quality in swine. In: Biotechnology for Control of Growth and Product Quality in Swine: Implications and Acceptability. Pudoc, 207-11, 1989.
Dantzer R. Interactions entre systèmes neuroendocrinien et immunitaire (Interactions between neuroendocrine and immune systems). In: Communication Cellulaire et Pathologie. INSERM, 169-73, 1988.
Dantzer R, Crestani F. Conditioned immune responses. In: Systems with Learning and Memory Abilities. Elsevier, 213-25, 1988.
Dantzer R. Bases comportementales et psychologiques de la douleur (Behavioral and psychological basis of pain). In: Pratique du Traitement de la Douleur. Doin, 39-46, 1988.
Dantzer R. Frustration, aggression and drugs. In: Ethopharmacology of Agonistic Behaviour in Animals and Humans. Martinus Nijhoff, 1-13, 1987.
Dantzer R. Behavioural analysis of anxiolytic drug action. In: Experimental Approach in Psychopharmacology. Humana Press, 269-97, 1987.
Le Moal M, Bluthé RM, Dantzer R, Bloom FE, Koob GF. The role of arginin vasopressin and other neuropeptides in brain-body integration. In: Cognitive Neurochemistry. Oxford University Press, 203-32, 1987.
Mormède P, Dantzer R. Implications of the porcine stress syndrome for animal welfare. In: Evaluation and Control of Meat Quality in Pigs. Martinus Nijhoff, 89-98, 1987.
Dantzer R, Tazi A, Bluthé RM, Koob GF, Le Moal M. Neuropeptides and behavior. In: Ion Channels in Neural Membranes: Proceedings of the 11th International Conference on Biological Membranes held at Crans-sur-Sierre, Switzerland, June 10-14, 1985. Alan R. Liss, 347-62, 1986.
Dantzer R, Raab A. On the interpration and signifiance of behavioural and physiological indicators of stress related to social space in domestic animals. In: Social Space in Farm Animals. Martinus Nijhoff, 3-14, 1986.
Dantzer R. Assessing pain in farm animals by physiological responses. In: Assessment of Pain in Farm Animals. CEC, 39-46, 1986.
Dantzer R, Mormède P. The behavior of swine and its relevance to cardiovascular research. In: Swine in Cardiovascular Research. CRC Press, 61-73, 1986.
Dantzer R, Signoret JP, Auffray P. Le comportement du porc (Behavior of pigs). In: Le Porc. Maloine, 144-56, 1986.
Le Moal M, Bluthé RM, Lebrun C, Koob GF, Bloom FE, Dantzer R. A propos de l'arginine vasopressine: effets comportementaux et analyse de ses propriétés de stimulus (Behavioral effects and properties of arginine vasopressin). In: L'actualité en Gérontologie: Physiologie et Physiopathologie Endocriniennes au Cours du Vieillissement. Editions Sandoz, 22-3, 1986.
Dantzer R, Mormède P. Stress in domestic animals: a psychoneuroendocrine perspective. In: Animal Stress. American Physiological Society, 81-95, 1985.
Dantzer R. Benzodiazepines and the limbic system. In: Psychopharmacology of the Limbic System. Oxford University Press, 148-63, 1984.
Dantzer R. Psychobiologie des émotions (Psychobiology of emotions). In: Neurobiologie du Comportement. Hermann, 109-43, 1984.
Mormède P, Bluthé RM, Dantzer R. Neuroendocrine strategies for assessing welfare: Application in calf management systems. In: Indicators Relevant to Farm Animal Welfare. Martinus Nijhoff, 39-46, 1983.
Dantzer R, Mormède P, Henry JP. Physiological assessment of adaptation in farm animals. In: Farm Animal Housing and Welfare. Martinus Nijhoff, 8-19, 1983.
Dantzer R, Mormède P, Henry JP. Significance of physiological criteria in assessing animal welfare. In: Indicators Relevant to Farm Animal Welfare. Martinus Nijhoff, 29-37, 1983.
Dantzer R, Mormède P. Behavioural consequences of frustration and conflict in pigs. In: Disturbed Behaviour of Farm Animals. Eugen Ulmer, 89-100, 1982.
Dantzer R, Bluthé RM, Tazi A, Mormède P, Ettenberg A, Van der Kooy D, Koob GF, Le Moal M. Aversive stimulus properties of peripherally injected vasopressin. In: Drug Discrimination: Application in CNS Pharmacology. Elsevier, 305-14, 1982.
Dantzer R. Research on farm animal transport in France: a survey. In: Transport of Animals Intented for Breeding, Production and Slaughter. Martinus Nijhoff, 218-31, 1982.
Dantzer R, Mormede P. Can physiological criteria be used to assess welfare in pigs?. In: The Welfare of Pigs. Martinus Nijhoff, 53-74, 1981.
Meissonier E, Dantzer R, Renault L, Mornet P. Pathologie de groupe (Production disease in intensive husbandry). In: Le Veau. Maloine, 289-99, 1977.
Dantzer R. Pharmacologie de l'apprentissage et de la mémoire (Pharmacology of learning and memory). In: Neurobiologie de L'apprentissage. Masson, 84-97, 1977.

Books (edited and written)

Dantzer R, Capuron L. Inflammation-Associated Depression: Evidence, Mechanisms, and Implication. Springer International Publishing, 2017.
Kordon C, Robinson I, Hanoune J, Dantzer R, (Eds) CY. Brain Somatic Cross-Talk and the Central Control of Metabolism. Springer, 2003.
Burgat R, (Eds) DR. Les Animaux D'elevage Ont-Ils Droit Au Bien-Etre. Paris: Institut National de la Recherche Agronomique, 2001.
Le Quéré Cady V, Dantzer R, Aynaud JM, Le Neindre P, Renard JP, Vignon. Les Filles d'Ariane. INRA, 2001.
Dantzer R, Wollman EE, (Eds) YR. Cytokines, Stress and Depression. Kluwer Academic/Plenum, 1999.
Bruchon-Schweitzer M, R(Eds) D. Introduction à la Psychologie de la Santé. Presses Universitaires de France, 1994.
Dantzer R. Les Emotions (Emotions). Ed(s) 2nd. Presses Universitaires de France, 1994.
Dantzer R. The Psychosomatic Delusion. The Free Press, 1993.
Rothwell NJ, (Eds) DR. Interleukin-1 in the Brain. Pergamon, 1992.
Claverie B, Le Bars D, Zavialoff N, Dantzer R. Douleurs: Société, Personne et Expressions (Pain, Society, Human Person and Expressions). Eshel, 1992.
Claverie B, Le Bars D, Zavialoff N, Dantzer R. Douleurs, du Neurone à l'Homme Souffrant (Pain, from Neurons to Human Suffering). Eshel, 1991.
Zayan R, Danter R. Social Stress in Domestic Animals. Kluwer, 1990.
Dantzer R. L'Illusion Psychosomatique (The Psychosomatic Illusion). Editions Odile Jacob, 1989.
Dantzer R. Les Emotions (Emotions). Presses Universitaires de France, 1988.
Dantzer R, Mormède P. Le Stress en Élevage Intensif (Stress in Intensive Husbandry). Masson, 1979.

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CV information above last modified March 23, 2026

Robert Dantzer, DVM, PhD

About Dr. Robert Dantzer

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Internal Medicine division

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Robert Dantzer, DVM, PhD

About Dr. Robert Dantzer

Present Title & Affiliation

Primary Appointment

Dual/Joint/Adjunct Appointment

Education & Training

Degree-Granting Education

Experience & Service

Faculty Academic Appointments

Administrative Appointments/Responsibilities

Other Professional Positions

Intramural Institutional Committee Activities

Editorial Activities

Honors & Awards

Professional Memberships

Selected Presentations & Talks

Local Presentations

National Presentations

International Presentations

Formal Peers

Grant & Contract Support

Selected Publications

Peer-Reviewed Articles

Invited Articles

Review Articles

Editorials

Abstracts

Book Chapters

Books (edited and written)

Patient Reviews

Request an Appointment

Related Links

Dantzer Laboratory

Symptom Research department

Internal Medicine division

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Help #EndCancer

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