Subrata Sen, Ph.D.

Peer-Reviewed Articles

1. Yang G, Mercado-Uribe I, Multani S, Sen S, Shih IM, Wong KK, Gershenson DM, Lui J. Ras promotes tumorgenesis through genomic instability induced by imbalanced expression of Aurora-A and BRCA2 in midbody during cytokinasis. International J. Cancer 133(2):275-285, 2013.
2. Torchia EC, Zhang L, Huebner AJ, Sen S, Roop DR. Aurora Kinase-A Dificiency During Skin Development Impairs Cell Division and Stratification. J. Invest Dermatol 133:78-86, 2012.
3. Liu Q, Chen J, Mai B, Amos C, Killary AM, Sen S, Wei C, Frazier ML. A single-nucleotide polymorphism in tumor suppressor gene SEL1L as a predictive and prognostic marker for pancreatic ductal adenocarcinoma in caucasians. Mol Carcinog 51(5):433-8, 2012. e-Pub 2011.
4. Katayama H, Wang J, Treekitkarnmongkol W, Kawai H, Sasai K, Zhang H, Wang H, Adams HP, Jiang S, Chakraborty SN, Suzuki F, Arlinghaus RB, Liu J, Mobley JA, Grizzle WE, Wang H, Sen S. Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73. Cancer Cell 21(2):196-211, 2012.
5. Derenzini E, Lemoine M, Buglio D, Katayama H, Ji Y, Davis RE, Sen S, Younes A. The JAK inhibitor AZD1480 regulates proliferation and immunity in Hodgkin lymphoma. Blood Cancer J 12(46), 2011.
6. Wang J, Sen S. MicroRNA functional network in pancreatic cancer: From biology to biomarkers of disease. J Biosci 36(3):481-491, 2011.
7. Chen J, Wu X, Pande M, Amos CI, Killary AM, Sen S, Frazier ML. Susceptibility locus for lung cancer at 15q25.1 is not associated with risk of pancreatic cancer. Pancreas 40(6):872-875, 2011. PMID: 21697764.
8. Katayama H, Sen S. Functional Significance of Aurora Kinase A Regulatory Interactions with p53-ERα Complex in Human Breast Cancer Cells. Horm Cancer 2(2):117-124, 2011.
9. Balasenthil S, Chen N, Lott ST, Chen J, Carter J, Grizzle WE, Frazier ML, Sen S, Killary AM. A migration signature and plasma biomarker panel for pancreatic adenocarcinoma. Cancer Prev Res (Phila) 4(1):137-49, 2011. e-Pub 2010.
10. Katayama H, Sen S. Aurora kinase inhibitors as anticancer molecules. Biochim Biophys Acta 1799(10-12):829-839, 2010.
11. Molli PR, Li DQ, Bagheri-Yarmand R, Pakala SB, Katayama H, Sen S, Iyer J, Chernoff J, Tsai MY, Nair SS, Kumar R. Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A. J Cell Biol 190(1):101-114, 2010. e-Pub 2010. PMID: 20603326.
12. Yang G, Chang B, Yang F, Guo X, Cai KQ, Xiao XS, Wang H, Sen S, Hung MC, Mills GB, Chang S, Multani AS, Mercado-Uribe I, Liu J. Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin Cancer Res 16(12):3171-3181, 2010. e-Pub 2010. PMID: 20423983.
13. Frenkel M, Mishra BM, Sen S, Yang P, Pawlus A, Vence L, Leblanc A, Cohen L, Banerji P, Banerji P. Cytotoxic effects of ultra-diluted remedies on breast cancer cells. Int J Oncol 36(2):395-403, 2010.
14. Chen J, Amos CI, Merriman KW, Wei Q, Sen S, Killary AM, Frazier ML. Genetic variants of p21 and p27 and pancreatic cancer risk in non-Hispanic Whites: a case-control study. Pancreas 39(1):1-4, 2010. PMID: 19910837.
15. Zhu J, Sen S, Wei C, Frazier ML. Cyclin D1b represses breast cancer cell growth by antagonizing the action of cyclin D1a on estrogen receptor alpha-mediated transcription. Int J Oncol 36(1):39-48, 2010.
16. Sen S. Aurora-C: the youngest of "the three (Aurora kinase) tenors" of mitotic symphony. Cell Cycle 8(19):3076-7, 2009.
17. Wang J, Chen J, Chang P, LeBlanc A, Li D, Abbruzzesse JL, Frazier ML, Killary AM, Sen S. MicroRNAs in plasma of pancreatic ductal adenocarcinoma patients as novel blood-based biomarkers of disease. Cancer Prev Res (Phila) 2(9):807-813, 2009. e-Pub 2009.
18. Torchia EC, Chen Y, Sheng H, Katayama H, Fitzpatrick J, Brinkley WR, Caulin C, Sen S, Roop DR. A genetic variant of Aurora kinase A promotes genomic instability leading to highly malignant skin tumors. Cancer Res 69(18):7207-7215, 2009. e-Pub 2009. PMID: 19738056.
19. Mazumdar A, Henderson YC, El-Naggar AK, Sen S, Clayman GL. Aurora Kinase A Inhibition and Paclitaxel as Targeted Combination Therapy for Head and Neck Squamous Cell Carcinoma. Head Neck 31(5):625-34, 2009. e-Pub 2008. PMID: 19107951.
20. Lott ST, Chen N, Chandler DS, Yang Q, Wang L, Rodriguez M, Xie H, Balasenthil S, Buchholz TA, Sahin AA, Chaung K, Zhang B, Olufemi SE, Chen J, Adams H, Band V, El-Naggar AK, Frazier ML, Keyomarsi K, Hunt KK, Sen S, Haffty B, Hewitt SM, Krahe R, Killary AM. DEAR1 is a dominant regulator of acinar morphogenesis and an independent predictor of local recurrence free survival in early onset breast cancer. PLoS Med 6(5):e1000068, 2009. e-Pub 2009. PMID: 19536326.
21. Chen J, Li D, Killary AM, Sen S, Amos CI, Evans DB, Abbruzzese JL, Frazier ML. Polymorphisms of p16, p27, p73, and MDM2 modulate response and survival of pancreatic cancer patients treated with preoperative chemoradiation. Ann Surg Oncol 16(2):431-9, 2009. e-Pub 2008.
22. Chen J, Killary AM, Sen S, Amos CI, Evans DB, Abbruzzese JL, Frazier ML. Polymorphisms of p21 and p27 jointly contribute to an earlier age at diagnosis of pancreatic cancer. Cancer Lett 272(1):32-9, 2008. e-Pub 2008.
23. Park HS, Park WS, Bondaruk J, Tanaka N, Katayama H, Lee S, Spiess PE, Steinberg JR, Wang Z, Katz RL, Dinney C, Elias KJ, Lotan Y, Naeem RC, Baggerly K, Sen S, Grossman HB, Czerniak B. Quantitation of Aurora Kinase a gene copy number in urine sediments and bladder cancer detection. J Natl Cancer Inst 100(19):1401-1411, 2008. e-Pub 2008. PMID: 18812553.
24. Katayama H, Sasai K, Kloc M, Brinkley BR, Sen S. Aurora kinase-A regulates kinetochore/chromatin associated microtubule assembly in human cells. Cell Cycle 7(17):2691-704, 2008.
25. Sasai K, Parant JM, Brandt ME, Carter J, Adams HP, Stass SA, Killary AM, Katayama H, Sen S. Targeted disruption of Aurora-A causes abnormal mitotic spindle assembly, chromosome misalignment and embryonic lethality. Oncogene 27(29):4122-4127, 2008. e-Pub 2008.
26. Sen S, Katayama H, Sasai K. Functional significance of Aurora Kinase A in Centrosome amplification and genomic instability. Adv Exp Med Biol 617:99-108, 2008.
27. Katayama H, Sasai K, Czerniak BA, Carter JL, Sen S. Aurora-A kinase phosphorylation of Aurora-A kinase interacting protein (AIP) and stabilization of the enzyme-substrate complex. J Cell Biochem 102(5):1318-1331, 2007.
28. Chen J, Li D, Wei C, Sen S, Killary AM, Amos CI, Evans DB, Abbruzzese JL, Frazier ML. Aurora-A and p16 polymorphisms contribute to an earlier age at diagnosis of pancreatic cancer in Caucasians. Clin Cancer Res 13(10):3100-3104, 2007. PMID: 17505013.
29. Chen J, Sen S, Amos CI, Wei C, Jones JS, Lynch P, Frazier ML. Association between Aurora-A kinase polymorphisms and age of onset of hereditary nonpolyposis colorectal cancer in a Caucasian population. Mol Carcinog 46(4):249-56, 2007.
30. Hu Q, Lu JF, Luo R, Sen S, Maity SN. Inhibition of CBF/NF-Y mediated transcription activation arrests cells at G2/M phase and suppresses expression of genes activated at G2/M phase of the cell cycle. Nucleic Acids Res 34:6272-85, 2007.
31. Shi Y, Reiman T, Li W, Maxwell CA, Sen S, Pilarski L, Daniels TR, Penichet ML, Feldman R, Lichtenstein A. Targeting aurora kinases as therapy in multiple myeloma. Blood 109:3915-3921, 2007.
32. Carter JL, Jin Li, Sen S. Genomic and expression array profiling of chromosome 20q amplicon in human colon cancer cells. Human Genetics 11:128-134, 2005.
33. Hu W, Kavanagh JJ, Deaver M, Johnston DA, Freedman RS, Verschraegen CF, Sen S. Frequent overexpression of STK15/Aurora-A/BTAK and chromosomal instability in tumorigenic cell cultures derived from human ovarian cancer. Oncol Res 15(1):49-57, 2005.
34. Fraizer GC, Diaz MF, Lee IL, Grossman HB, Sen S. Aurora-A/STK15/BTAK enhances chromosomal instability in bladder cancer cells. Int J Oncol 25(6):1631-9, 2004.
35. Sasai K, Katayama H, Stenoien DL, Fujii S, Honda R, Kimura M, Okano Y, Tatsuka M, Suzuki F, Nigg EA, Earnshaw WC, Brinkley WR, Sen S. Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. Cell Motil Cytoskeleton 59(4):249-63, 2004. PMID: 15499654.
36. Katayama H, Sasai K, Kawai H, Yuan ZM, Bondaruk J, Suzuki F, Fujii S, Arlinghaus RB, Czerniak BA, Sen S. Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. Nat Genet 36(1):55-62, 2004. e-Pub 2003. PMID: 14702041.
37. Royce ME, Xia W, Sahin AA, Katayama H, Johnston DA, Hortobagyi G, Sen S, Hung MC. STK15/Aurora-A expression in primary breast tumors is correlated with nuclear grade but not with prognosis. Cancer 100(1):12-9, 2004.
38. Hoque A, Carter J, Xia W, Hung MC, Sahin AA, Sen S, Lippman SM. Loss of aurora A/STK15/BTAK overexpression correlates with transition of in situ to invasive ductal carcinoma of the breast. Cancer Epidemiol Biomarkers Prev 12(12):1518-22, 2003.
39. Katayama H, Brinkley WR, Sen S. Aurora kinase-A regulates kinetochore/chromatin associated microtubule assembly in human cells. Cancer Metastasis Rev 22(3):451-464, 2003.
40. Mayer F, Stoop H, Sen S, Bokemeyer C, Oosterhuis JW, Looijenga LH. Aneuploidy of human testicular germ cell tumors is associated with amplification of centrosomes. Oncogene 22:3859-66, 2003.
41. Stenoien DL, Sen S, Mancini MA, Brinkley BR. Dynamic association of a tumor amplified kinase, Aurora-A, with the centrosome and mitotic spindle. Cell Motil Cytoskeleton 55:134-46, 2003.
42. Li D, Zhu J, Firozi PF, Abbruzzese JL, Evans DB, Cleary K, Friess H, Sen S. Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer. Clin Cancer Res 9:991-7, 2003.
43. Sen S, Zhou H, Zhang RD, Yoon DS, Vakar-Lopez F, Ito S, Jiang F, Johnston D, Grossman HB, Ruifrok AC, Katz RL, Brinkley W, Czerniak B. Amplification/overexpression of a mitotic kinase gene in human bladder cancer. J Natl Cancer Inst 94:1320-9, 2002.
44. Li F, Adam L, Vadlamudi RK, Zhou H, Sen S, Chernoff J, Mandal M, Kumar R. p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells. EMBO Rep 3:767-73, 2002.
45. Crosio C, Fimia GM, Loury R, Kimura M, Okano Y, Zhou H, Sen S, Allis CD, Sassone-Corsi P. Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases. Mol Cell Biol 22:874-85, 2002.
46. Katayama H, Zhou H, Li Q, Tatsuka M, Sen S. Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle. J Biol Chem 276(49):46219-24, 2001. e-Pub 2001.
47. Zhou H, Kuang J, Zhong L, Kuo WL, Gray JW, Sahin A, Brinkley BR, Sen S. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat Genet 20(2):189-93, 1998.
48. Kuo MT, Sen S, Hittelman WN, Hsu TC. Chromosomal fragile sites and DNA amplification in drug-resistant cells. Biochem Pharmacol 56:7-13, 1998.
49. Kuo MT, Sen S, Teeter L, Cailleau RM, Knesek JE, Bowen J. Expression of endogenous murine leukemia virus in transplantable tumor cells and DNA methylation of the viral sequences. Cancer Res 44:3518-21, 1984.

Invited Articles

1. Katayama H, Sen S. Aurora Kinase inhibitors as Anticancer Molecules. Biochim Biophys Acta 1799(10-12):829-39, 2010. e-Pub 2010. PMID: 20863917.
2. Sen S. Aurora-C Joins "The Three (Aurora Kinase) Tenors of Mitotic Symphony". Cell Cycle (News & Views), 2009.
3. Sen S. Aneuploidy. Encyclopedia of Cancer, 2nd Edition, Springer Verlag, Berlin Heidelberg:158-164, 2008.
4. Katayama H, Brinkley WR, Sen S. The Aurora kinases: role in cell transformation and tumorigenesis. Cancer Metastasis Rev 22(4):451-64, 2003. PMID: 12884918.
5. Sen S. Aneuploidy and cancer. Curr Opin Oncol 12(1):82-8, 2000. PMID: 10687734.

Book Chapters

1. Sen S, Katayama H, Sasai K. Functional Significance of Aurora Kinase A in Centrosome Amplification & Genomic Instability. In: Hormonal Carcinogenesis (ed. Li JJ, Li SA, Mohla S, Rochefort H, Maudelonde T), 99-108, 2008.
2. Sharma T, Cheong N, Sen P, Sen S. Constitutive heterochromatin and evolutionary divergence of Mus dunni, Mus booduga and Mus musculus. In: Current Topics in Microbiology and Immunology. Springer Verlag, 1986.