Apar Pataer, MD, PhD

Peer-Reviewed Articles

1. Corsini EM, Weissferdt A, Pataer A, Zhou N, Antonoff MB, Hofstetter WL, Mehran RJ, Rajaram R, Rice DC, Roth JA, Vaporciyan AA, Walsh GL, Cascone T, Heymach JV, Swisher SG, Sepesi B. Pathological nodal disease defines survival outcomes in patients with lung cancer with tumour major pathological response following neoadjuvant chemotherapy. Eur J Cardiothorac Surg 59(1):100-108, 2021. PMID: 32864702.
2. Weissferdt A, Pataer A, Vaporciyan AA, Correa AM, Sepesi B, Moran CA, Wistuba II, Roth JA, Shewale JB, Heymach JV, Kalhor N, Cascone T, Hofstetter WL, Lee JJ, Swisher SG. Agreement on Major Pathological Response in NSCLC Patients Receiving Neoadjuvant Chemotherapy. Clin Lung Cancer 21(4):341-348, 2020. e-Pub 2020. PMID: 32279936.
3. Zhang X, Zhang R, Chen H, Wang L, Ren C, Pataer A, Wu S, Meng QH, Ha MJ, Morris J, Xi Y, Wang J, Zhang J, Gibbons DL, Heymach JV, Meric-Bernstam F, Minna J, Swisher SG, Roth JA, Fang B. KRT-232 and navitoclax enhance trametinib's anti-Cancer activity in non-small cell lung cancer patient-derived xenografts with KRAS mutations. Am J Cancer Res 10(12):4464-4475, 2020. e-Pub 2020. PMID: 33415011.
4. Chen Y, Zhang R, Wang L, Correa AM, Pataer A, Xu Y, Zhang X, Ren C, Wu S, Meng QH, Fujimoto J, Jensen VB, Antonoff MB, Hofstetter WL, Mehran RJ, Pisimisis G, Rice DC, Sepesi B, Vaporciyan AA, Walsh GL, Swisher SG, Roth JA, Heymach JV, Fang B. Tumor characteristics associated with engraftment of patient-derived non-small cell lung cancer xenografts in immunocompromised mice. Cancer 125(21):3738-3748, 2019. e-Pub 2019. PMID: 31287557.
5. Asik E, Akpinar Y, Caner A, Kahraman N, Guray T, Volkan M, Albarracin C, Pataer A, Arun B, Ozpolat B. EF2-kinase targeted cobalt-ferrite siRNA-nanotherapy suppresses BRCA1-mutated breast cancer. Nanomedicine (Lond) 14(17):2315-2338, 2019. e-Pub 2019. PMID: 31432749.
6. Baity M, Wang L, Correa AM, Zhang X, Zhang R, Pataer A, Wu S, Meng QH, Antonoff MB, Hofstetter WL, Mehran RJ, Rice DC, Roth JA, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Zhao M, Gu J, Fang B. Glutathione reductase (GSR) gene deletion and chromosome 8 aneuploidy in primary lung cancers detected by fluorescence in situ hybridization. Am J Cancer Res 9(6):1201-1211, 2019. e-Pub 2019. PMID: 31285952.
7. Pu X, Zhang R, Wang L, Chen Y, Xu Y, Pataer A, Meraz IM, Zhang X, Wu S, Wu L, Su D, Mao W, Heymach JV, Roth JA, Swisher SG, Fang B. Patient-derived tumor immune microenvironments in patient-derived xenografts of lung cancer. J Transl Med 16(1):328, 2018. e-Pub 2018. PMID: 30477533.
8. Bircan HA, Gurbuz N, Pataer A, Caner A, Kahraman N, Bayraktar E, Bayraktar R, Erdogan MA, Kabil N, Ozpolat B. Elongation factor-2 kinase (eEF-2K) expression is associated with poor patient survival and promotes proliferation, invasion and tumor growth of lung cancer. Lung Cancer 124:31-39, 2018. e-Pub 2018. PMID: 30268477.
9. Pataer A, Shao R, Correa AM, Behrens C, Roth JA, Vaporciyan AA, Wistuba II, Swisher SG. Major pathologic response and RAD51 predict survival in lung cancer patients receiving neoadjuvant chemotherapy. Cancer Med 7(6):2405-2414, 2018. e-Pub 2018. PMID: 29673125.
10. Parra ER, Villalobos P, Behrens C, Jiang M, Pataer A, Swisher SG, William WN, Zhang J, Lee J, Cascone T, Heymach JV, Forget MA, Haymaker C, Bernatchez C, Kalhor N, Weissferdt A, Moran C, Zhang J, Vaporciyan A, Gibbons DL, Sepesi B, Wistuba II. Effect of neoadjuvant chemotherapy on the immune microenvironment in non-small cell lung carcinomas as determined by multiplex immunofluorescence and image analysis approaches. J Immunother Cancer 6(1):48, 2018. e-Pub 2018. PMID: 29871672.
11. Cascone T, Gold KA, Swisher SG, Liu DD, Fossella FV, Sepesi B, Pataer A, Weissferdt A, Kalhor N, Vaporciyan AA, Hofstetter WL, Wistuba II, Heymach JV, Kim ES, William WN. Induction Cisplatin Docetaxel Followed by Surgery and Erlotinib in Non-Small Cell Lung Cancer. Ann Thorac Surg 105(2):418-424, 2018. e-Pub 2017. PMID: 29217088.
12. Gentile E, Oba T, Lin J, Shao R, Meng F, Cao X, Lin HY, Mourad M, Pataer A, Baladandayuthapani V, Cai D, Roth JA, Ji L. Cationic liquid crystalline nanoparticles for the delivery of synthetic RNAi-based therapeutics. Oncotarget 8(29):48222-48239, 2017. PMID: 28637023.
13. Dalvi MP, Wang L, Zhong R, Kollipara RK, Park H, Bayo J, Yenerall P, Zhou Y, Timmons BC, Rodriguez-Canales J, Behrens C, Mino B, Villalobos P, Parra ER, Suraokar M, Pataer A, Swisher SG, Kalhor N, Bhanu NV, Garcia BA, Heymach JV, Coombes K, Xie Y, Girard L, Gazdar AF, Kittler R, Wistuba II, Minna JD, Martinez ED. Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors. Cell Rep 19(8):1669-1684, 2017. PMID: 28538184.
14. Hao C, Shao R, Raju U, Fang B, Swisher SG, Pataer A. Accumulation of RNA-dependent protein kinase (PKR) in the nuclei of lung cancer cells mediates radiation resistance. Oncotarget 7(25):38235-38242, 2016. PMID: 27203671.
15. Bozorov K, Zhao JY, Elmuradov B, Pataer A, Aisa HA. Recent developments regarding the use of thieno[2,3-d]pyrimidin-4-one derivatives in medicinal chemistry, with a focus on their synthesis and anticancer properties. Eur J Med Chem 102:552-573, 2015. e-Pub 2015. PMID: 26312434.
16. Guo C, Hao C, Shao R, Fang B, Correa AM, Hofstetter WL, Roth JA, Behrens C, Kalhor N, Wistuba II, Swisher SG, Pataer A. RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancer. Oncotarget 6(13):11114-24, 2015. PMID: 25798539.
17. Hao C, Wang L, Peng S, Cao M, Li H, Hu J, Huang X, Liu W, Zhang H, Wu S, Pataer A, Heymach JV, Eterovic AK, Zhang Q, Shaw KR, Chen K, Futreal A, Wang M, Hofstetter W, Mehran R, Rice D, Roth JA, Sepesi B, Swisher SG, Vaporciyan A, Walsh GL, Johnson FM, Fang B. Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer. Cancer Lett 357(1):179-85, 2015. e-Pub 2014. PMID: 25444907.
18. Hellmann MD, Chaft JE, William WN, Rusch V, Pisters KM, Kalhor N, Pataer A, Travis WD, Swisher SG, Kris MG, University of Texas MD Anderson Lung Cancer Collaborative Group. Pathological response after neoadjuvant chemotherapy in resectable non-small-cell lung cancers: proposal for the use of major pathological response as a surrogate endpoint. Lancet Oncol 15(1):e42-50, 2014. PMID: 24384493.
19. Guo C, Shao R, Correa AM, Behrens C, Johnson FM, Raso MG, Prudkin L, Solis LM, Nunez MI, Fang B, Roth JA, Wistuba II, Swisher SG, Lin T, Pataer A. Prognostic Significance of Combinations of RNA-Dependent Protein Kinase and EphA2 Biomarkers for NSCLC. J Thorac Oncol 8(3):301-308, 2013. PMID: 23370317.
20. William WN, Pataer A, Kalhor N, Correa AM, Rice DC, Wistuba II, Heymach J, Lee JJ, Kim ES, Munden R, Gold KA, Papadimitrakopoulou V, Swisher SG, Erasmus JJ, University of Texas M.D. Anderson Lung Cancer Collaborative Research Group. Computed tomography RECIST assessment of histopathologic response and prediction of survival in patients with resectable non-small-cell lung cancer after neoadjuvant chemotherapy. J Thorac Oncol 8(2):222-8, 2013. PMID: 23287849.
21. Guo C, Lu H, Gao W, Wang L, Lu K, Wu S, Pataer A, Huang M, El-Zein R, Lin T, Roth JA, Mehran R, Hofstetter W, Swisher SG, Wu X, Fang B. Insulin-like growth factor binding protein-2 level is increased in blood of lung cancer patients and associated with poor survival. PLoS One 8(9):e74973, 2013. e-Pub 2013. PMID: 24069370.
22. Pataer A, Kalhor N, Correa AM, Raso MG, Erasmus JJ, Kim ES, Behrens C, Lee JJ, Roth JA, Stewart DJ, Vaporciyan AA, Wistuba II, Swisher SG, University of Texas M. D. Anderson Lung Cancer Collaborative Research Group. Histopathologic response criteria predict survival of patients with resected lung cancer after neoadjuvant chemotherapy. J Thorac Oncol 7(5):825-32, 2012. PMID: 22481232.
23. He Y, Zhou Z, Hofstetter WL, Zhou Y, Hu W, Guo C, Wang L, Guo W, Pataer A, Correa AM, Lu Y, Wang J, Diao L, Byers LA, Wistuba II, Roth JA, Swisher SG, Heymach JV, Fang B. Aberrant expression of proteins involved in signal transduction and DNA repair pathways in lung cancer and their association with clinical parameters. PLoS One 7(2):e31087, 2012. e-Pub 2012. PMID: 22348039.
24. He Y, Correa AM, Raso MG, Hofstetter WL, Fang B, Behrens C, Roth JA, Zhou Y, Yu L, Wistuba II, Swisher SG, Pataer A. The Role of PKR/eIF2a Signaling Pathway in Prognosis of Non-Small Cell Lung Cancer. PLoS One 6(11):e24855, 2011. e-Pub 2011. PMID: 22102852.
25. Zhou Y, Hofstetter WL, He Y, Hu W, Pataer A, Wang L, Wang J, Zhou Y, Yu L, Fang B, Swisher SG. KLF4 inhibition of lung cancer cell invasion by suppression of SPARC expression. Cancer Biol Ther 9(7):507-13, 2010. e-Pub 2010. PMID: 20215880.
26. Pataer A, Raso MG, Correa AM, Behrens C, Tsuta K, Solis L, Fang B, Roth JA, Wistuba II, Swisher SG. Prognostic significance of RNA-dependent protein kinase on non-small cell lung cancer patients. Clin Cancer Res 16(22):5522-8, 2010. e-Pub 2010. PMID: 20930042.
27. Fuson KL, Zheng M, Craxton M, Pataer A, Ramesh R, Chada S, Sutton RB. Structural mapping of post-translational modifications in human interleukin-24: role of N-linked glycosylation and disulfide bonds in secretion and activity. J Biol Chem 284(44):30526-33, 2009. e-Pub 2009. PMID: 19734147.
28. Hu W, Hofstetter WL, Li H, Zhou Y, He Y, Pataer A, Wang L, Xie K, Swisher SG, Fang B. Putative tumor-suppressive function of kruppel-like factor 4 in primary lung carcinoma. Clin Cancer Res 15(18):5688-95, 2009. e-Pub 2009. PMID: 19737957.
29. Hu W, Hofstetter W, Wei X, Guo W, Zhou Y, Pataer A, Li H, Fang B, Swisher SG. Double-stranded RNA-dependent protein kinase-dependent apoptosis induction by a novel small compound. J Pharmacol Exp Ther 328(3):866-72, 2009. e-Pub 2008. PMID: 19066342.
30. Pataer A, Swisher SG, Roth JA, Logothetis CJ, Corn PG. Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity. Cancer Biol Ther 8(3):245-52, 2009. e-Pub 2009. PMID: 19106640.
31. Hu W, Hofstetter W, Guo W, Li H, Pataer A, Peng HH, Guo ZS, Bartlett DL, Lin A, Swisher SG, Fang B. JNK-deficiency enhanced oncolytic vaccinia virus replication and blocked activation of double-stranded RNA-dependent protein kinase. Cancer Gene Ther 15(9):616-24, 2008. e-Pub 2008. PMID: 18535619.
32. Pataer A, Hu W, Xiaolin L, Chada S, Roth JA, Hunt KK, Swisher SG. Adenoviral endoplasmic reticulum-targeted mda-7/interleukin-24 vector enhances human cancer cell killing. Mol Cancer Ther 7(8):2528-2535, 2008. PMID: 18723497.
33. Pataer A, Chada S, Roth JA, Hunt KK, Swisher SG. Development of Ad-mda7/IL-24-resistant lung cancer cell lines. Cancer Biol Ther 7(1):103-8, 2008. PMID: 18059175.
34. von Holzen U, Pataer A, Raju U, Bocangel D, Vorburger SA, Liu Y, Lu X, Roth JA, Aggarwal BB, Barber GN, Keyomarsi K, Hunt KK, Swisher SG. The double-stranded RNA-activated protein kinase mediates radiation resistance in mouse embryo fibroblasts through nuclear factor kappaB and Akt activation. Clin Cancer Res 13(20):6032-9, 2007. PMID: 17947465.
35. Takada Y, Ichikawa H, Pataer A, Swisher S, Aggarwal BB. Genetic deletion of PKR abrogates TNF-induced activation of Iκβα kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation. Oncogene 26(8):1201-1212, 2007. e-Pub 2006. PMID: 16924232.
36. Pataer A, Bocangel D, Chada S, Roth JA, Hunt KK, Swisher SG. Enhancement of adenoviral MDA-7-mediated cell killing in human lung cancer cells by geldanamycin and its 17-allyl- amino-17-demethoxy analogue. Cancer Gene Ther 14(1):12-18, 2007. PMID: 17024233.
37. Pataer A, Fanale MA, Roth JA, Swisher SG, Hunt KK. Induction of apoptosis in human lung cancer cells following treatment with amifostine and an adenoviral vector containing wild-type p53. Cancer Gene Ther 13(8):806-814, 2006. PMID: 16628227.
38. Chada S, Mhashilkar AM, Liu Y, Nishikawa T, Bocangel D, Zheng M, Vorburger SA, Pataer A, Swisher SG, Ramesh R, Kawase K, Meyn RE, Hunt KK. mda-7 gene transfer sensitizes breast carcinoma cells to chemotherapy, biologic therapies and radiotherapy: correlation with expression of bcl-2 family members. Cancer Gene Ther 13(5):490-502, 2006. PMID: 16282987.
39. von Holzen U, Bocangel D, Pataer A, Vorburger SA, Liu Y, Lu X, Hunt KK, Swisher SG. Role for the double-stranded RNA-activated protein kinase PKR in Ad-TNF-alpha gene therapy in esophageal cancer. Surgery 138(2):261-268, 2005. PMID: 16153435.
40. Pataer A, Vorburger SA, Chada S, Balachandran S, Barber GN, Roth JA, Hunt KK, Swisher SG. Melanoma differentiation-associated gene-7 protein physically associates with the double-stranded RNA-activated protein kinase PKR. Mol Ther 11(5):717-723, 2005. PMID: 15851010.
41. Sieger KA, Mhashilkar AM, Stewart A, Sutton RB, Strube RW, Chen SY, Pataer A, Swisher SG, Grimm EA, Ramesh R, Chada S. The tumor suppressor activity of MDA-7/IL-24 is mediated by intracellular protein expression in NSCLC cells. Mol Ther 9(3):355-367, 2004. PMID: 15006602.
42. Vorburger SA, Pataer A, Swisher SG, Hunt KK. Genetically targeted cancer therapy: tumor destruction by PKR activation. Am J Pharmacogenomics 4(3):189-98, 2004. PMID: 15174900.
43. Pataer A, Chada S, Hunt KK, Roth JA, Swisher SG. Adenoviral melanoma differentiation-associated gene 7 induces apoptosis in lung cancer cells through mitochondrial permeability transition-independent cytochrome c release. J Thorac Cardiovasc Surg 125(6):1328-1335, 2003. PMID: 12830052.
44. Vorburger SA, Pataer A, Yoshida K, Liu Y, Lu X, Swisher SG, Hunt KK. The mitochondrial apoptosis-inducing factor plays a role in E2F-1-induced apoptosis in human colon cancer cells. Ann Surg Oncol 10(3):314-322, 2003. PMID: 12679318.
45. Vorburger SA, Pataer A, Yoshida K, Barber GN, Xia W, Chiao P, Ellis LM, Hung MC, Swisher SG, Hunt KK. Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis. Oncogene 21(41):6278-6288, 2002. PMID: 12214268.
46. Nutt LK, Chandra J, Pataer A, Fang B, Roth JA, Swisher SG, O'Neil RG, McConkey DJ. Bax-mediated Ca2+ mobilization promotes cytochrome c release during apoptosis. J Biol Chem 277(23):20301-20308, 2002. PMID: 11909872.
47. Pataer A, Vorburger SA, Barber GN, Chada S, Mhashilkar AM, Zou-Yang H, Stewart AL, Balachandran S, Roth JA, Hunt KK, Swisher SG. Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR). Cancer Res 62(8):2239-2243, 2002. PMID: 11956076.
48. Nutt LK, Pataer A, Pahler J, Fang B, Roth J, McConkey DJ, Swisher SG. Bax and Bak promote apoptosis by modulating endoplasmic reticular and mitochondrial Ca2+ stores. J Biol Chem 277(11):9219-9225, 2002. PMID: 11741880.
49. Hiai H, Pataer A, Nishimura M. Polygenic resistance to mouse pulmonary adenomas. Exp Lung Res 26:617-625, 2000. PMID: 11195459.
50. Pataer A, Fang B, Yu R, Kagawa S, Hunt KK, McDonnell TJ, Roth JA, Swisher SG. Adenoviral Bak overexpression mediates caspase-dependent tumor killing. Cancer Res 60(4):788-792, 2000. PMID: 10706081.
51. Pataer A, Smythe WR, Yu R, Fang B, McDonnell T, Roth JA, Swisher SG. Adenovirus-mediated Bak gene transfer induces apoptosis in mesothelioma cell lines. J Thorac Cardiovasc Surg 121(1):61-67, 2000. PMID: 11135160.
52. Hiai H, Yamada Y, Shisa H, Kamoto T, Pataer A, Lu LM. To be or not to be a T-lymphomas, that is determined by a dominant gene Tlsm-1 in mouse models. Leukemia Suppl 3:193-194, 1998.
53. Pataer A, Mori TJ, Takahashi T, Tanaka F, Kasyu I, Sand H, Hiai, H. Loss of heterozygosity (LOH) at 17q and 14q in human lung cancers. Oncogene 17:3029-3033, 1998. PMID: 9881705.
54. Lu LM, Ogawa M, Kamoto T, Yamada Y, Pataer A, Hiai H. Expression of LECAM-1 and LFA-1 on pre-B lymphoma cells but not on preneoplastic pre-B cells in SL/KH mice. Leuk Res 21(4):337-342, 1997. PMID: 9150351.
55. Hiai H, Pataer A, Nishimura M, Kamoto T. Pulmonary adenoma susceptibility and resistance genes. Mol Med 34:676-681, 1997.
56. Pataer A, Nishimura M, Kamoto T, Ichioka K, Sato M, Hiai H. Genetic resistance to urethan-induced pulmonary adenomas in SMXA recombinant inbred mouse strains. Cancer Res 57(14):2904-2908, 1997. PMID: 9230199.
57. Pataer A, Kamoto T, Lu LM, Yamada Y, Hiai H. Two dominant host resistance genes to pre-B lymphoma in wild-derived inbred mouse strain MSM/Ms. Cancer Res 56:3716-3720, 1996. PMID: 8706013.
58. Kamoto T, Shisa H, Pataer A, Lu L, Yoshida O, Yamada Y, Hiai H. A quantitative trait locus in major histocompatibility complex determining latent period of mouse lymphomas. Jpn J Cancer Res 87(4):401-404, 1996. PMID: 8641972.
59. Pataer A, Matsushima Y, Komoto T, Lida F, Honda Y, Hiai H. Mapping of rupture of lens cataract (rlc) on mouse chromosome 14. Genomics 36:553-554, 1996. PMID: 8884285.
60. Pataer A, Yamada Y, Haller O, Kobayashi H, Kamoto T, Lu LM, Ogawa M, Ishimoto A, Katoh H, Kanehira K, Ikegami S, Fukumoto M, Hiai H. The origin of SL family mice. Lab Anim Sci 46(4):410-417, 1996. PMID: 8872992.
61. Matsushima Y, Kamoto T, Ideda F, Pataer A, Hiai H. Rupture of lens cataract: a novel recessive mutant locus mapped on mouse chromosome. Genomics 20:125-127, 1996.
62. Nakajima Y, Iwasa Y, Zhou J, Toyokuni S, Pataer A, Kakehi Y. Prostatic duct adenocarcinoma: (endometrioid carcinoma of the prostate). Hosp Pathol 12:128, 1995.
63. Hiai H Yamada Y, Shisa H, Ogawa M, Matsushiro H, Kamoto T, Pataer A. Host genetic determination of susceptibility and types of lymphomas. Radiat Biol Res 30:71-81, 1995.
64. Sawada M, Horiguchi Y, Pataer A, Miyake N, Kitamura Y, Midorikawa O, Hiai H. Monoclonal antibodies to a zinc-binding protein of rat Paneth cells. J Histochem Cytochem 42:467-472, 1994. PMID: 8126373.
65. Pataer A, Ozpolat B, Shao R, Cashman NR, Plotkin SS, Samuel CE, Lin SH, Kabil NN, Wang J, Majidi M, Fang B, Roth JA, Vaporciyan AA, Wistuba II, Hung MC, Swisher SG. Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells. Oncogene. e-Pub 2019. PMID: 31554935.

Book Chapters

1. Chada S, Bocangel D, Pataer A, Sieger K, Mhashilkar AM, Inoue S, Miyahara R, Roth JA, Swisher S, Hunt KK, Ramesh R. MDA-7/IL-24 as a multi-modality therapy for cancer. In: Gene Therapy for Cancer. Humana Press, 413-434, 2007.
2. Hiai H, Yamada Y, Pataer A, Lu L-M, Kamoto T, Tsuruyama T. Genetic and epigenetic susceptibility to endogenous retrovirus-induced lymphomas in SL mice. In: Animal models of cancer predisposition syndromes: Progress in Experimental Tumor Research. Karger, 64-77, 1999.