Ajay Sheshadri, M.S., M.D.

Peer-Reviewed Articles

1. Sheshadri A, Alousi A, Bashoura L, Stolar K, Baghaie S, Arain MH, Noor L, Balagani A, Jain A, Blanco D, Ortiz A, Peterson SK, Langhals R, Taylor M, Stenzler A, Mehta RS, Popat UR, Hosing C, Rondon G, Shen F, Li L, Cheng GS, Ost DE, Champlin RE, Dickey BF. Feasibility and Reliability of Home-based Spirometry Telemonitoring in Allogeneic Hematopoietic Cell Transplant Recipients. Ann Am Thorac Soc 17(10):1329-1333, 2020. PMID: 32614241.
2. Bailey M, Eapen G, Ost D, Casal RF, Jimenez C, Datar S, Molina S, Bashoura L, Faiz SA, Balachandran DD, Shannon VR, Sheshadri A, Grosu HB. Routine Microbiologic Studies of Pleural Fluid Specimens in Cancer Patients. American Journal of Medicine S0002-9343(19):240-244, 2020. e-Pub 2019. PMID: 31401163.
3. Grosu H, Lu W, Ost D, Vial M, Hernandez M, Ghosh N, Noor L, Arain M, Bashoura L, Faiz S, Balachandran D, Casal R, Eapen G, Shannon V, Sheshadri A, Tang X, Wistuba I. A Longitudinal Assessment of Pleural Fluid Cytokines in Patients with Malignant Pleural Effusions Treated with an Indwelling Pleural Catheter: Can We Predict Pleurodesis?. J Bronchology Interv Pulmonol 27(1):4-13, 2020. PMID: 31373905.
4. Grosu HB, Lu W, Ost DE, Vial MR, Hernandez M, Ghosh N, Noor L, Hasan AM, Bashoura L, Faiz S, Balachandran D, Casal R, Eapen G, Shannon V, Sheshadri A, Tang X, Rahman N, Wistuba II. Pleural Fluid Cytokine Levels at Baseline and Over Time are Associated With Time to IPC Removal: An Exploratory Study. J Bronchology Interv Pulmonol 27(1):4-13, 2020. e-Pub 2019. PMID: 31373905.
5. Sheshadri A, Karimipour M, Vakil E, Bashoura L, Godoy M, Arain MH, Evans SE, Dickey BF, Ost DE, Chemaly RF, Faiz SA. Refinement of estimates of mortality risk using the Radiologic Severity Index in hematologic malignancy patients with respiratory syncytial virus infection. Transpl Infect Dis 21(4):e13105, 2019. e-Pub 2019. PMID: 31081570.
6. Sheshadri A, Chemaly RF, Alousi AM, Shah PK, Rondon G, Bashoura L, Kmeid J, Azzi J, Blanco DW, Kaous M, Dickey BF, Champlin RE, Shah DP. Pulmonary impairment following respiratory viral infections is associated with high mortality in allogeneic hematopoietic cell transplant recipients. Biol Blood Marrow Transplant 25(4):800-809, 2019. e-Pub 2018. PMID: 30521974.
7. Debiane L, Reitzel R, Rosenblatt J, Gagea M, Chavez MA, Adachi R, Grosu HB, Sheshadri A, Hill LR, Raad I, Ost DE. A Design-Based Stereologic Method to Quantify the Tissue Changes Associated with a Novel Drug-Eluting Tracheobronchial Stent. Respiration 98(1):1-10, 2019. e-Pub 2019. PMID: 30799409.
8. Lai K, Shannon VR, Balachandran D, Sheshadri A, Bashoura L, Faiz SA. Role of Infliximab in Immune Check Point Inhibitor Induced Pneumonitis. American Journal of Respiratory and Critical Care Medicine 199, 2019.
9. Sheshadri A, Godoy M, Erasmus JJ, Gruschkus S, Hasan A, Evans SE, Barreda-Garcia J, Chemaly RF, Dickey B, Ost D. Progression of the Radiologic Severity Index is associated with increased mortality and healthcare resource utilisation in acute leukaemia patients with pneumonia. BMJ Open Respir Res 6(1):e000471, 2019. e-Pub 2019. PMID: 31921429.
10. Vakil E, Sheshadri A, Faiz SA, Shah DP, Zhu Y, Li L, Kmeid J, Azzi J, Balagani A, Bashoura L, Ariza-Heredia E, Chemaly RF. Risk factors for mortality after respiratory syncytial virus lower respiratory tract infection in adults with hematologic malignancies. Transpl Infect Dis 20(6):e12994, 2018. e-Pub 2018. PMID: 30195271.
11. Patel S, Leavey A, Sheshadri A, Kumar P, Kandikuppa S, Tarsi J, Mukhopadhyay K, Johnson P, Balakrishnan K, Schechtman KB, Castro M, Yadama G, Biswas P. Associations between Household Air Pollution and Reduced Lung Function in Women and Children in Rural Southern India. Journal of Applied Tocicology 38(11):1405-1415, 2018. e-Pub 2018. PMID: 30047157.
12. Colen RR, Fujii T, Bilen MA, Kotrotsou A, Abrol S, Hess KR, Hajjar J, Suarez-Almazor ME, Alshawa A, Hong DS, Giniebra-Camejo D, Stephen B, Subbiah V, Sheshadri A, Mendoza T, Fu S, Sharma P, Meric-Bernstam F, Naing A. Radiomics to predict immunotherapy-induced pneumonitis: proof of concept. Invest New Drugs 36(4):601-607, 2018. e-Pub 2017. PMID: 29075985.
13. Fujii T, Colen RR, Bilen MA, Hess KR, Hajjar J, Suarez-Almazor ME, Alshawa A, Hong DS, Tsimberidou A, Janku F, Gong J, Stephen B, Subbiah V, Piha-Paul SA, Fu S, Sharma P, Mendoza T, Patel A, Thirumurthi S, Sheshadri A, Meric-Bernstam F, Naing A. Incidence of immune-related adverse events and its association with treatment outcomes: the MD Anderson Cancer Center experience. Invest New Drugs 36(4):638-646, 2018. e-Pub 2017. PMID: 29159766.
14. Sheshadri A, Shah DP, Godoy M, Erasmus JJ, Song J, Li L, Evans SE, Chemaly RF, Dickey BF, Ost DE. Progression of the Radiologic Severity Index Predicts Mortality in Patients with Parainfluenza Virus-Associated Lower Respiratory Infections. PLoS One 13(5):e0197418, 2018. e-Pub 2018. PMID: 29771962.
15. Ontiveros N, Eapen-John D, Osorio N, Song J, Li L, Sheshadri A, Tiang X, Ghosh N, Vaporciyan A, Correa A, Walsh G, Grosu HB, Ost DE. Predicting post-operative lung function following lobectomy: a new method to adjust for inherent selection bias. Respiration 96(5):434-445, 2018. e-Pub 2018. PMID: 30257257.
16. Berair R, Hartley R, Mistry V, Sheshadri A, Gupta S, Singapuri A, Gonem S, Marshall RP, Sousa AR, Shikotra A, Kay R, Wardlaw A, Bradding P, Siddiqui S, Castro M, Brightling CE. Associations in asthma between quantitative computed tomography and bronchial biopsy-derived airway remodelling. European Respiratory Journarl 49(5), 2017. e-Pub 2017. PMID: 28461289.
17. Sheshadri A, Chemaly R, Alousi A, Shah P, Rondon G, Bashoura L, Kmeid J, Azzi J, Blanco D, Kaous M, Dickey B, Champlin R, Shah D. Pulmonary Function Decline after Respiratory Viral Infection Predicts Mortality after Hematopoeitic Stem Cell Transplantation. American Journal of Transplantation, 2017.
18. Sheshadri A, Rodriguez A, Chen R, Kozlowski J, Burgdorf D, Koch T, Tarsi J, Schutz R, Wilson B, Schechtman K, Leader JK, Hoffman EA, Castro M, Fain SB, Gierada DS. Effect of Reducing Field of View on Multidetector Quantitative Computed Tomography Parameters of Airway Wall Thickness in Asthma. Journal of Computer Assisted Tomography 39(4):584-90, 2015. PMID: 25938213.
19. Thomen RP, Sheshadri A, Quirk JD, Kozlowski J, Ellison HD, Szczesniak RD, Castro M, Woods JC. Regional ventilation changes in severe asthma after bronchial thermoplasty with (3)He MR imaging and CT. Radiology 274(1):250-9, 2015. e-Pub 2014. PMID: 25144646.
20. Witt CA, Sheshadri A, Carlstrom L, Tarsi J, Kozlowski J, Wilson B, Gierada DS, Hoffman E, Fain SB, Cook-Granroth J, Sajol G, Sierra O, Giri T, O'Neill M, Zheng J, Schechtman KB, Bacharier LB, Jarjour N, Busse W, Castro M, NHLBI Severe Asthma Research Program (SARP). Longitudinal changes in airway remodeling and air trapping in severe asthma. Academic Radiology 21(8):986-93, 2014. PMID: 25018070.
21. Castro M, King TS, Kunselman SJ, Cabana MD, Denlinger L, Holguin F, Kazani SD, Moore WC, Moy J, Sorkness CA, Avila P, Bacharier LB, Bleecker E, Boushey HA, Chmiel J, Fitzpatrick AM, Gentile D, Hundal M, Israel E, Kraft M, Krishnan JA, LaForce C, Lazarus SC, Lemanske R, Lugogo N, Martin RJ, Mauger DT, Naureckas E, Peters SP, Phipatanakul W, Que LG, Sheshadri A, Smith L, Solway J, Sullivan-Vedder L, Sumino K, Wechsler ME, Wenzel S, White SR, Sutherland ER, National Heart, Lung, and Blood Institute’s AsthmaNet. Effect of vitamin D3 supplementation on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. Journal of the American Medical Association 311(20):2083-91, 2014. PMID: 24838406.
22. Sheshadri A, Saliba R, Patel B, Ahmed T, Bueno L, Arain M, Mehta R, Popat U, Hosing C, Rondon G, Bashoura L, Dickey B, Champlin R, Alousi A. Risk of hematologic relapse after azithromycin exposure in allogeneic hematopoietic cell transplant recipients. Bone Marrow Transplantation.
23. Hall C, Goss C, Trivedi A, Sheshadri A, Kozlowski J, Gierada D, Sieren J, McEleney S, Escher M, Saylor M, Schutz R, Schechtman K, Fain S, Schiebler M, Jarjour N, Leader K, Trudeau J, Wenzel S, Erzurum S, Lempel J, Moore W, Bleecker E, Hoffman E, Castro M.. Repeatability of CT airway measurements in severe asthma. American Journal of Respiratory and Critical Care Medicine.

Invited Articles

1. Jose R, Dickey B, Sheshadri A. Airway Diseases in Hematologic malignancies. Clinical Pulmonary Medicine, 2020.
2. Jain A, Shannon V, Sheshadri A. Pneumonitis after precision oncology therapies: a concise review. Journal of Immunotherapy and Precision Oncology 1(1):26-37, 2018.
3. Sheshadri A, McKenzie M, Castro M. Critical Review of Bronchial Thermoplasty: Where Should It Fit in Asthma Therapy?. Curr Allergy and Asthma Rep 14(11):470, 2014. PMID: 25189294.
4. Sheshadri A, Castro M, Chen A. Bronchial thermoplasty: a novel therapy for severe asthma. Clin Chest Med 34(3):437-444, 2013. e-Pub 2013. PMID: 23993815.

Other Articles

1. Balagani A, Arain M, Sheshadri A. Case report: Bronchiolitis obliterans after combination immunotherapy with pembrolizumab and ipilimumab. J Immunother Precis Oncol 1(1):49-52, 2018.
2. Valley T, Sheshadri A, Hoopman T A young man with empyema: a report of isolated fusobacterial disease. Infect Dis Clin Pract 19(6):e31-e32, 2011.
3. Patel B, Sheshadri A, Faiz SA Cavitary Lesions in a Hematopoietic Stem Cell Transplant Patient. Arch Bronconeumol. PMID: 32576396.

Editorials

1. Sheshadri A. Quantitative lung imaging in hematopoietic cell transplant recipients: a window into the physiology of bronchiolitis obliterans. Chest 158(3):852-853, 2020. PMID: 32892879.
2. Sumino K, Sheshadri A, Castro M. Calcium channel blocker reduces airway remodeling. Or does it?. Am J Respir Crit Care Med 191(8):876-83, 2015. PMID: 25876196.
3. Sheshadri A, Hoffman EA, Castro M. Can computed tomography help us identify asthmatic phenotypes?. J Allergy Clin Immunol 133(3):739-40, 2014. PMID: 24472625.
4. Sheshadri A, Hoffman EA, Castro M. Can CT help us identify asthmatic phenotypes?. J Allergy Clin Immunol 133:739-40, 2014.

Abstracts

1. Mendoza TR, Hong D, Naing A, Hess KR, Sheshadri A, Altan M, Stephen BA, Cleeland C. Evaluating the psychometric properties of the immunotherapy module of the MD Anderson Symptom Inventory (MDASI-Immunotherapy). Joint Statistical Meetings 2019, 2019.
2. Patel B, Sheshadri A, Saliba R, Rondon G, Ahmed T, Arain M, Mehta R, Popat U, Hosing C, Bashoura L, Dickey B, Champlin R, Alousi A. Azithromycin Exposure Following Hematopoietic Stem Cell Transplantation Is Associated with an Increased Risk of Cancer Relapse in Acute Leukemia. Biology of Blood and Marrow Transplantation 25(3):S100-S289, 2019.
3. Sheshadri A, Godoy M, Erasmus J, Arain M, Evans S, Barreda-Garcia J, Chemaly R, Dickey B, Ost D. Progression of the Radiologic Severity Index is associated with increased mortality in patients with acute leukemia who develop pneumonia after induction chemotherapy. American Journal of Respiratory and Critical Care Medicine 199, 2019.
4. Sang K, Shannon V, Sheshadri A, Kantarjian H, Garcia-Manero G, Ravandi F, Naing A, Sharma P, Im J, Ruiz Vasquez W, Diab A, Kontoyiannis D, Futreal A, Daver N. Immunophenotypic Analysis of T Cells from Leukemia Patients with Immune Checkpoint Inhibitor-Associated Respiratory Complications. American College of Rheumatology, 2018.
5. Sheshadri A, Balagani A, Alousi A, Bashoura L, Stolar K, Arain M, Noor L, Blanco D, Ortiz A, Goodwin N, Chen M, Li L, Hess K, Chemaly R, Ost D, Peterson S, Champlin R, Dickey B.. Feasibility and Validity of a Home-based Spirometry Program after Hematopoietic Stem Cell Transplantation for the Early Detection of Pulmonary Impairment. American Journal of Respiratory and Critical Care Medicine 197, 2018.
6. Sood S, Sajol G, Goss C, Sheshadri A, Comhair A, Erzurum S, Hall C, Weaver R, Schutz R, Kozlowski J, Castro M. Longitudinal evaluation of airway remodeling in asthma over time by airway biopsy. American Journal of Respiratory and Critical Care Medicine 197, 2018.
7. Kim S, Shannon V, Sheshadri A, Kantarjian H, Garcia-Manero G, Im J, Ravandi F, Naing A, Sharma P, Kontoyiannis D, Futreal A, Daver N. Th1/17 Cells are Expanded in Bronchial Alveolar Lavage (BAL) Fluid from Leukemia Patients with Checkpoint Inhibitor-Induced Pneumonitis. Blood 130:3588, 2017.
8. Hall C, Trivedi AP, Sheshadri A, Boomer J, Yin Declue H, Sajol G, Goss C, Kozlowski J, Gierada D, Sieren JP, Escher M, Schutz R, Li H, Schechtman KB, Moore WC, Bleecker ER, Hofman EA, Castro M, on behalf of the NHLBI Severe Asthma Research Program (SARP). Airway Remodeling Measured by Targeted Biopsies in Severe Asthma. American Journal of Respiratory and Critical Care Medicine 195, 2017.
9. Trivedi A, Sheshadri A, Goss C, Sieren J, Escher M, Schutz R, Li H, Schechtman K, Moore W, Bleecker E, Hoffman E, Castro M. The Use Of CT To Characterize Cluster Phenotypes In The Severe Asthma Research Program. American Journal of Respiratory and Critical Care Medicine 195, 2017.
10. Sheshadri A, Kmeid J, Azzi J, Kaous M, Blanco D, Bashoura L, Rondon G, Alousi A, Dickey B, Chemaly R, Shah D. Pulmonary Function Decline after Respiratory Viral Infection Predicts Mortality after Hematopoetic Cell Transplantation. American Thoracic Society, 2017.
11. Sheshadri A, Jiao J, Carlstrom L, Sieren JP, Escher M, Sajol G, Yin-Declue H, Tarsi J, Schutz R, Wilson B, Li H, Schechtman K, Moore WC, Bleecker ER, Hoffman EA, Castro M. MDCT Characteristics of Pre-Specified Asthmatic Cluster Phenotypes in the Severe Asthma Research Program. American Journal of Respiratory and Critical Care Medicine, 2015.
12. Sarikonda K, Sheshadri A, Koch T, Kozlowski J, Wilson B, Schechtman K, Chen A, Castro M. Predictors of Bronchial Thermoplasty Response in Patients with Severe Refractory Asthma. American Journal of Respiratory and Critical Care Medicine, 2014.
13. Sheshadri A, Rodriguez A, Chen R, Kozlowski J, Burgdorf D, Koch T, Tarsi J, Sajol G, Yin-Declue H, Wilson B, Schechtman K, Castro M, Fain S, Gierada D. Reducing Field of View in Multi-Detector Quantitative Computed Tomography Improves Accuracy of Measures of Airway Wall Remodeling. American Journal of Respiratory and Critical Care Medicine, 2014.
14. Sheshadri A, Thomen R, Kozlowski J, Gierada D, Tarsi J, Koch T, Burgdorf D, Sajol G, Yin-DeClue H, Wilson B, Schechtman K, Quirk J, Castro M, Woods J. Ventilation defects with hyperpolarized helium MRI in severe asthma before and after bronchial thermoplasty. American Journal of Respiratory and Critical Care Medicine 187, 2013.
15. Thomen R, Sheshadri A, Kozlowski J, Quirk J, Chang Y, Castro M, Woods J. Ventilation Quantification Bronchopulmonary Segments in Severe Asthma Using 3He MRI and High Resolution CT. American Journal of Respiratory and Critical Care Medicine 187, 2013.
16. Sheshadri A, Witt C, Gierada D, Kozlowski J, Hoffman EA, Cook-Granroth J, Fain SB, Busse WW, Zheng J, Wilson B, Schechtman K, Castro M. Predictors of Airway Remodeling and Decline in Lung Function in Severe Asthma. American Journal of Respiratory and Critical Care Medicine 185, 2012.
17. Sheshadri A, Mineo C, Yuhanna IS, Shaul PW. Inhibition of HDL-mediated eNOSactivation by the SR-BI inhibitor glyburide, 2005.
18. Gordon N, Kleinerman ES, Sheshadri A, Blanco DW, Yedururi S, Morani A, Gill JB, Harrison DJ, Herzog CE, Livingston JA, Benjamin RS, Mireles ME, Kawedia J, Daw NC. A Phase I Trial of Aerosol Gemcitabine for the Treatment of Patients with Solid Tumors and Lung Metastases. Journal of Clinical Oncology 38(15).
19. Krings JG, Goss C, Lew D, Samant M, McGregor MC, Jonathan Boomer J, Bacharier LB, Sheshadri A, Hall C, Brownell J, Schechtman KB, Peterson S, McEleney S, Mauger DT, Fahy JV, Fain SB, Denlinger L, Washko G, Hoffman E, Wenzel SE and Castro M. Quantitative CT imaging in adults with asthma can predict both future lung function decline and asthma morbidity: results from the SARP III study. American Thoracic Society.
20. George GC, Mendoza TR, Naing A, Hong D, Cleeland C, Sheshadri A, Hess KR, Altan M, Stephen BA, Castillo L, Rodriguez E, Yap TA, Janku F, Fu S, Pant S, Subbiah V, Piha-Paul SA, Karp DD, Meric-Bernstam F. Symptom Burden of Patients with Metastatic Solid Tumors Receiving Pembrolizumab in an Early Phase Trial.

Book Chapters

1. Zhong L, Altan M, Shannon VR, Sheshadri A. Immune-related Adverse Events: Pneumonitis. In: Adv Exp Med Biol, 255-269, 2020.
2. Aslam W, Sheshadri A, Lamb C. Chapter 12: Bronchial Thermoplasty. In: Practical Guide to Interventional Pulmonology. 1. Elsevier, 2020.
3. Zhong L, Altan M, Shannon V, Sheshadri A. Immune-related adverse events: pneumonitis. In: Immunotherapy. 3rd. Springer International Publishing, 2020.
4. Jain A, Shannon VR, Sheshadri A. Immune-related Adverse Events: Pneumonitis. In: Adv Exp Med Biol. 2nd, 131-149, 2018.
5. Sarikonda K, Sheshadri A and Castro M. Asthma. In: The Washington Manual of Outpatient Medicine. 2nd. Lippincott, Williams & Wilkins: Philadelphia, 2015.
6. Sheshadri A and Castro M. Asthma. In: The Washington Manual of Medical Therapeutics. 34th ed. Lippincott, Williams & Wilkins: Philadelphia, 2013.
7. Shannon V, Eapen G, Jimenez C, Grosu H, Morice RC, Bashoura L, Sheshadri A, Evans S, Adachi R, Kroll M, Faiz S, Balachandran D, Pravinkumar S, Dickey B. Respiratory Complication. In: Cancer Medicine. 10.