Alberto Diaz De Leon, M.D.

Peer-Reviewed Articles

1. Landan MacDonald, Haesun Choi, Hyunseon Christine Kang, Diaz De Leon A, Irene Inguillo, Abhi Maharjan, Justin Gregg, John Ward. Is Confirmatory Prostate Biopsy Necessary in Active Surveillance Patients With an Initial Magnetic Resonance Imaging Ultrasound Fusion Biopsy? 3(8):e00083, 2025. e-Pub 2025.
2. Diaz De Leon A, Haesun Choi, Diaz De Leon A, Hyunseon Christine Kang, Suprateek Kundu, Wei Qiao, Zhouxuan Li, Irene A. Inguillo, Abhi Maharjan, Justin R. Gregg, John F. Ward. Magnetic Resonance Imaging Ultrasound Volume Discrepancy as a Predictor of Magnetic Resonance Imaging Ultrasound Fusion-Guided Targeted Biopsy Performance. JU Open Plus 3(8):e00089, 2025.
3. Taffel MT, Khatri G, Purysko AS, Avery R, Caserta MP, Chang SD, De Leon AD, Ganeshan D, Gupta RT, Lew SQ, Lyshchik A, Nicola R, Piel C Jr, Sener A, Smith AD, Nikolaidis P. ACR Appropriateness Criteria(R) Renal Transplant Dysfunction: 2024 Update. J Am Coll Radiol 22(5S):S372-S395, 2025. e-Pub 2025. PMID: 40409889.
4. Brixey, AG, Fung, AW, Diaz De Leon, A, Walker, CM, Porter, KK, Khatri, G, Bang, TJ, Batra, K, Carter, B, Christensen, JD, Cox, CW, Davis, AM, Holley, AB, Kandathil, A, Little, BP, Madan, R, Mehta, P, Moore, W, Shroff, G, Uyeda, J, Nikolaidis, P, Kamel, IR, Chung, J. ACR Appropriateness Criteria® Sepsis. Journal of the American College of Radiology 21(6):S292-S309, 2024. e-Pub 2024. PMID: 38823951.
5. Venishetty, N, Taylor, J, Xi, Y, Howard, JM, Ng, YS, Wong, D, Woldu, SL, Diaz De Leon, A, Pedrosa, I, Margulis, V, Bagrodia, A. Testicular Radiomics To Predict Pathology At Time of Postchemotherapy Retroperitoneal Lymph Node Dissection for Nonseminomatous Germ Cell Tumor. Clinical Genitourinary Cancer 22(1):33-37, 2024. e-Pub 2024. PMID: 37468341.
6. Recchimuzzi DZ, Diaz de Leon A, Pedrosa I, Travalini D, Latin H, Goldberg K, Meng X, Begovic J, Rayan J, Roehrborn CG, Rofsky NM, Costa DN. Direct MRI-guided In-Bore Targeted Biopsy of the Prostate: A Step-by-Step How To and Lessons Learned. Radiographics 44(2):e230142, 2024. e-Pub 2024. PMID: 38175803.
7. Gupta RT, Kalisz K, Khatri G, Caserta MP, Catanzano TM, Chang SD, De Leon AD, Gore JL, Nicola R, Prabhakar AM, Savage SJ, Shah KP, Surabhi VR, Taffel MT, Valente JH, Yoo DC, Nikolaidis P. ACR Appropriateness Criteria(R) Acute Onset Flank Pain-Suspicion of Stone Disease (Urolithiasis). J Am Coll Radiol 20(11S):S315-S328, 2023. e-Pub 2023. PMID: 38040458.
8. Ganeshan, DM, Khatri, G, Ali, N, Avery, RJ, Caserta, MP, Chang, S, Diaz De Leon, A, Gupta, RT, Lyshchik, A, Michalski, J, Nicola, R, Pierorazio, P, Purysko, AS, Smith, A, Taffel, MT, Nikolaidis, P. ACR Appropriateness Criteria® Staging of Renal Cell Carcinoma. Journal of the American College of Radiology 20(5):S246-S264, 2023. e-Pub 2023. PMID: 37236747.
9. Costa DN, Meng X, Tverye A, Bagrodia A, Recchimuzzi DZ, Xi Y, Arraj P, Shah RB, Subramanian N, Diaz de Leon A, Roehrborn CG, Rofsky NM, Chen H, Pedrosa I. Preoperative multiparametric prostate magnetic resonance imaging structured report informs risk for positive apical surgical margins during radical prostatectomy. J Comput Assist Tomogr 47(1):38-44, 2023. e-Pub 2022. PMID: 35995580.
10. Smith, A, Nikolaidis, P, Khatri, G, Chong, S, Diaz De Leon, A, Ganeshan, DM, Gore, JL, Gupta, RT, Kwun, R, Lyshchik, A, Nicola, R, Purysko, AS, Savage, SJ, Taffel, MT, Yoo, DC, Delaney, EW, Lockhart, M. ACR Appropriateness Criteria® Acute Pyelonephritis. Journal of the American College of Radiology 19(11):S224-S239, 2022. e-Pub 2022. PMID: 36436954.
11. Purysko, AS, Nikolaidis, P, Khatri, G, Aurón-Gómez, M, Diaz De Leon, A, Ganeshan, DM, Gore, JL, Gupta, RT, Shek-Man Lo, S, Lyshchik, A, Savage, SJ, Smith, A, Taffel, MT, Yoo, DC, Lockhart, M. ACR Appropriateness Criteria® Post-Treatment Follow-up and Active Surveillance of Clinically Localized Renal Cell Carcinoma. Journal of the American College of Radiology 19(5):S156-S174, 2022. e-Pub 2022. PMID: 35550799.
12. Hannan R, Mohamad O, Diaz de Leon A, Manna S, Pop LM, Zhang Z, Mannala S, Christie A, Christley S, Monson N, Ishihara D, Hsu EJ, Ahn C, Kapur P, Chen M, Arriaga Y, Courtney K, Cantarel B, Wakeland EK, Fu YX, Pedrosa I, Cowell L, Wang T, Margulis V, Choy H, Timmerman RD, Brugarolas J. Outcome and Immune Correlates of a Phase II Trial of High-Dose Interleukin-2 and Stereotactic Ablative Radiotherapy for Metastatic Renal Cell Carcinoma. Clin Cancer Res 27(24):6716-6725, 2021. e-Pub 2021. PMID: 34551906.
13. Udayakumar D, Zhang Z, Xi Y, Dwivedi DK, Fulkerson M, Haldeman S, McKenzie T, Yousuf Q, Joyce A, Hajibeigi A, Notgrass H, de Leon AD, Yuan Q, Lewis MA, Madhuranthakam AJ, Sibley RC, Elias R, Guo J, Christie A, McKay RM, Cadeddu JA, Bagrodia A, Margulis V, Brugarolas J, Wang T, Kapur P, Pedrosa I. Deciphering Intratumoral Molecular Heterogeneity in Clear Cell Renal Cell Carcinoma with a Radiogenomics Platform. Clin Cancer Res 27(17):4794-4806, 2021. e-Pub 2021. PMID: 34210685.
14. Desai S, Jia L, Diaz de Leon A, Costa DN. Rare prostate cancer mimic on multiparametric MRI: Cowper's gland hyperplasia. Urol Case Rep 38:101675, 2021. e-Pub 2021. PMID: 33898268.
15. Costa DN, Jia L, Subramanian N, Xi Y, Rofsky NM, Recchimuzzi DZ, de Leon AD, Arraj P, Pedrosa I. Prospective PI-RADS v2.1 Atypical Benign Prostatic Hyperplasia Nodules With Marked Restricted Diffusion: Detection of Clinically Significant Prostate Cancer on Multiparametric MRI. AJR Am J Roentgenol 217(2):395-403, 2021. e-Pub 2021. PMID: 32876473.
16. Costa DN, Cai Q, Xi Y, Recchimuzzi DZ, Subramanian N, Bagrodia A, Rofsky NM, Roehrborn CG, Hornberger B, Shah RB, Goldberg K, Diaz de Leon A, Pedrosa I. Gleason Grade Group Concordance between Preoperative Targeted Biopsy and Radical Prostatectomy Histopathologic Analysis: A Comparison Between In-Bore MRI-guided and MRI-Transrectal US Fusion Prostate Biopsies. Radiol Imaging Cancer 3(2):e200123, 2021. e-Pub 2021. PMID: 33817652.
17. Steinberg RL, Rasmussen RG, Johnson BA, Ghandour R, De Leon AD, Xi Y, Yokoo T, Kim S, Kapur P, Cadeddu JA, Pedrosa I. Prospective performance of clear cell likelihood scores (ccLS) in renal masses evaluated with multiparametric magnetic resonance imaging. Eur Radiol 31(1):314-324, 2021. e-Pub 2021. PMID: 32770377.
18. Subramanian N, Recchimuzzi DZ, Xi Y, Diaz de Leon A, Chen H, Xie D, Goldberg K, Rofsky NM, Pedrosa I, Costa DN. Impact of the Number of Cores on the Prostate Cancer Detection Rate in Men Undergoing in-Bore Magnetic Resonance Imaging-Guided Targeted Biopsies. J Comput Assist Tomogr 45(2):203-209, 2021. e-Pub 2021. PMID: 33273160.
19. Courtney KD, Ma Y, Diaz de Leon A, Christie A, Xie Z, Woolford L, Singla N, Joyce A, Hill H, Madhuranthakam AJ, Yuan Q, Xi Y, Zhang Y, Chang J, Fatunde O, Arriaga Y, Frankel AE, Kalva S, Zhang S, McKenzie T, Reig Torras O, Figlin RA, Rini BI, McKay RM, Kapur P, Wang T, Pedrosa I, Brugarolas J. HIF-2 Complex Dissociation, Target Inhibition, and Acquired Resistance with PT2385, a First-in-Class HIF-2 Inhibitor, in Patients with Clear Cell Renal Cell Carcinoma. Clin Cancer Res 26(4):793-803, 2020. e-Pub 2020. PMID: 31727677.
20. Khatri G, Pedrosa I, Ananthakrishnan L, de Leon AD, Fetzer DT, Leyendecker J, Singal AG, Xi Y, Yopp A, Yokoo T. Abbreviated-protocol screening MRI vs. complete-protocol diagnostic MRI for detection of hepatocellular carcinoma in patients with cirrhosis: An equivalence study using LI-RADS v2018. J Magn Reson Imaging 51(2):415-425, 2020. e-Pub 2020. PMID: 31209978.
21. Yokoo T, Singal AG, Diaz de Leon A, Ananthakrishnan L, Fetzer DT, Pedrosa I, Khatri G. Prevalence and clinical significance of discordant LI-RADS® observations on multiphase contrast-enhanced MRI in patients with cirrhosis. Abdom Radiol (NY) 45(1):177-187, 2020. e-Pub 2020. PMID: 31342103.
22. Pirasteh A, Johnson B, Dimitrov IE, Costa DN, Diaz de Leon A, Xi Y, Madhuranthakam AJ, Pedrosa I. Turbo Spin-Echo Diffusion-Weighted Imaging in Prostate Magnetic Resonance Imaging of Men With Pelvic Hardware. J Comput Assist Tomogr 44(4):519-526, 2020. e-Pub 2020. PMID: 32697522.
23. Johnson BA, Kim S, Steinberg RL, de Leon AD, Pedrosa I, Cadeddu JA. Diagnostic performance of prospectively assigned clear cell Likelihood scores (ccLS) in small renal masses at multiparametric magnetic resonance imaging. Urol Oncol 37(12):941-946, 2019. e-Pub 2019. PMID: 31540830.
24. Costa DN, Goldberg K, Leon AD, Lotan Y, Xi Y, Aziz M, Freifeld Y, Margulis V, Raj G, Roehrborn CG, Hornberger B, Desai N, Bagrodia A, Francis F, Pedrosa I, Cadeddu JA. Magnetic Resonance Imaging-guided In-bore and Magnetic Resonance Imaging-transrectal Ultrasound Fusion Targeted Prostate Biopsies: An Adjusted Comparison of Clinically Significant Prostate Cancer Detection Rate. Eur Urol Oncol 2(4):397-404, 2019. e-Pub 2019. PMID: 31277776.
25. Vento J, Mulgaonkar A, Woolford L, Nham K, Christie A, Bagrodia A, de Leon AD, Hannan R, Bowman I, McKay RM, Kapur P, Hao G, Sun X, Brugarolas J. PD-L1 detection using (89)Zr-atezolizumab immuno-PET in renal cell carcinoma tumorgrafts from a patient with favorable nivolumab response. J Immunother Cancer 7(1):144, 2019. e-Pub 2019. PMID: 31155004.
26. Freifeld Y, Diaz de Leon A, Xi Y, Pedrosa I, Roehrborn CG, Lotan Y, Francis F, Costa DN. Diagnostic performance of prospectively assigned likert scale scores to determine extraprostatic extension and seminal vesicle invasion With multiparametric MRI of the prostate. AJR Am J Roentgenol 212(3):576-581, 2019. e-Pub 2019. PMID: 30589381.
27. Costa DN, Xi Y, Aziz M, Passoni N, Shakir N, Goldberg K, Francis F, Roehrborn CG, Leon AD, Pedrosa I. Prospective Inclusion of Apparent Diffusion Coefficients in Multiparametric Prostate MRI Structured Reports: Discrimination of Clinically Insignificant and Significant Cancers. AJR Am J Roentgenol 212(1):109-116, 2019. e-Pub 2019. PMID: 30383404.
28. Diaz de Leon A, Leyendecker JR, Otero-Muinelo S, Grewal H, Xi Y, Francis F, Pedrosa I, Costa DN. Reproducibility of Index Lesion Size and Mean Apparent Diffusion Coefficient Values Measured by Prostate Multiparametric MRI: Correlation With Whole-Mount Sectioning of Specimens. AJR Am J Roentgenol 211(4):783-788, 2018. e-Pub 2018. PMID: 30160988.
29. Diaz de Leon A, Costa DN, Francis F, Pedrosa I. Case 258: Granulomatous Prostatitis. Radiology 289(1):267-271, 2018. e-Pub 2018. PMID: 30230997.
30. Diaz de Leon A, Costa DN, Francis F, Pedrosa I. Case 258. Radiology 287(3):1070-1072, 2018. e-Pub 2018. PMID: 29782240.
31. Costa DN, Passoni NM, Leyendecker JR, de Leon AD, Lotan Y, Roehrborn CG, Otero-Muinelo S, Grewal H, Xi Y, Francis F, Rofsky NM, Pedrosa I. Diagnostic Utility of a Likert Scale Versus Qualitative Descriptors and Length of Capsular Contact for Determining Extraprostatic Tumor Extension at Multiparametric Prostate MRI. AJR Am J Roentgenol 210(5):1066-1072, 2018. e-Pub 2018. PMID: 29489410.
32. Kay FU, Canvasser NE, Xi Y, Pinho DF, Costa DN, Diaz de Leon A, Khatri G, Leyendecker JR, Yokoo T, Lay AH, Kavoussi N, Koseoglu E, Cadeddu JA, Pedrosa I. Diagnostic Performance and Interreader Agreement of a Standardized MR Imaging Approach in the Prediction of Small Renal Mass Histology. Radiology 287(2):543-553, 2018. e-Pub 2018. PMID: 29390196.
33. Mohamad O, Diaz de Leon A, Schroeder S, Leiker A, Christie A, Zhang-Velten E, Trivedi L, Khan S, Desai NB, Laine A, Albuquerque K, Iyengar P, Arriaga Y, Courtney K, Gerber DE, Hammers H, Choy H, Timmerman R, Brugarolas J, Hannan R. Safety and efficacy of concurrent immune checkpoint inhibitors and hypofractionated body radiotherapy. Oncoimmunology 7(7):e1440168, 2018. e-Pub 2018. PMID: 29900043.
34. Canvasser NE, Kay FU, Xi Y, Pinho DF, Costa D, de Leon AD, Khatri G, Leyendecker JR, Yokoo T, Lay A, Kavoussi N, Koseoglu E, Cadeddu JA, Pedrosa I. Diagnostic Accuracy of Multiparametric Magnetic Resonance Imaging to Identify Clear Cell Renal Cell Carcinoma in cT1a Renal Masses. J Urol 198(4):780-786, 2017. e-Pub 2017. PMID: 28457802.
35. Zhang Y, Udayakumar D, Cai L, Hu Z, Kapur P, Kho EY, Pavia-Jimenez A, Fulkerson M, de Leon AD, Yuan Q, Dimitrov IE, Yokoo T, Ye J, Mitsche MA, Kim H, McDonald JG, Xi Y, Madhuranthakam AJ, Dwivedi DK, Lenkinski RE, Cadeddu JA, Margulis V, Brugarolas J, DeBerardinis RJ, Pedrosa I. Addressing metabolic heterogeneity in clear cell renal cell carcinoma with quantitative Dixon MRI. JCI Insight 2(15), 2017. e-Pub 2017. PMID: 28768909.
36. de Leon AD, Xi Y, Champine J, Costa DN. Achieving ideal computed tomographic scan length in patient with suspected urolithiasis. J Comput Assist Tomogr 38(2):264-7, 2014. e-Pub 2014. PMID: 24448507.
37. Diaz de Leon A, Cronkhite JT, Yilmaz C, Brewington C, Wang R, Xing C, Hsia CCW, Garcia CK. Subclinical lung disease, macrocytosis, and premature graying in kindreds with telomerase (TERT) mutations. Chest 140(3):753-763, 2011. e-Pub 2011. PMID: 21349926.
38. Yilmaz C, Watharkar SS, Diaz de Leon A, Garcia CK, Patel NC, Jordan KG, Hsia CC. Quantification of regional interstitial lung disease from CT-derived fractional tissue volume: a lung tissue research consortium study. Acad Radiol 18(8):1014-23, 2011. e-Pub 2011. PMID: 21596593.
39. Diaz de Leon A, Cronkhite JT, Katzenstein AL, Godwin JD, Raghu G, Glazer CS, Rosenblatt RL, Girod CE, Garrity ER, Xing C, Garcia CK. Telomere lengths, pulmonary fibrosis and telomerase (TERT) mutations. PLoS One 5(5):e10680, 2010. e-Pub 2010. PMID: 20502709.
40. Parrott D, Yuan Q, Pinho D, Xi Y, Costa DN, Diaz De Leon A, Dakanali M, Sun X, Oz OK, Bowen S, Rofsky NM, Mathews D, Pedrosa I. Characterization of suspicious prostate lesions at multiparametric MRI with dynamic 68 Ga-Gozetotide PET/CT. PMID: 41077599.

Review Articles

1. Diaz de Leon A, Davenport MS, Silverman SG, Schieda N, Cadeddu JA, Pedrosa I. Role of Virtual Biopsy in the Management of Renal Masses. AJR Am J Roentgenol 212(6):1234-1243, 2019. e-Pub 2019. PMID: 30995092.
2. de Leon AD, Kapur P, Pedrosa I. Radiomics in Kidney Cancer: MR Imaging. Magn Reson Imaging Clin N Am 27(1):1-13, 2019. e-Pub 2019. PMID: 30466904.
3. Diaz de Leon A, Pirasteh A, Costa DN, Kapur P, Hammers H, Brugarolas J, Pedrosa I. Current Challenges in Diagnosis and Assessment of the Response of Locally Advanced and Metastatic Renal Cell Carcinoma. Radiographics 39(4):998-1016, 2019. e-Pub 2019. PMID: 31199711.
4. Diaz de Leon A, Pedrosa I. Imaging and screening of kidney cancer. Radiol Clin North Am 55(6):1235-1250, 2017. e-Pub 2017. PMID: 28991563.
5. Khatri G, de Leon AD, Lockhart ME. MR Imaging of the Pelvic Floor. Magn Reson Imaging Clin N Am 25(3):457-480, 2017. e-Pub 2017. PMID: 28668155.
6. Diaz de Leon A, Costa D, Pedrosa I. Role of Multiparametric MR Imaging in Malignancies of the Urogenital Tract. Magn Reson Imaging Clin N Am 24(1):187-204, 2016. e-Pub 2016. PMID: 26613881.