Amanda L. Olson, M.D.
Department of Stem Cell Transplantation and Cellular Therapy, Division of Cancer Medicine
About Dr. Olson
Dr. Olson completed Hematology and Oncology fellowship at Memorial Sloan-Kettering in 2013 where her research focus was related to optimization of umbilical cord blood transplantation and infectious complications following hematopoietic stem cell transplant in adults. She currently is an Associate Professor of Medicine in the Department of Stem Cell Transplantation and Cellular Therapy where she oversees clinical research related to cord blood transplantation, mesenchymal stem cell manipulation and cellular therapy. Dr. Olson is the Principal Investigator for several cellular therapy trials including a Phase I trial of mesenchymal stem cells transfected with plasmid containing interferon beta for the treatment of refractory epithelial ovarian cancer, an international, multi-institutional, Phase III study evaluating the use of cord blood derived mesenchymal stem cell expansion to expedite hematopoietic engraftment following stem cell transplantation, a Phase I trial of IV mesenchymal stem cells for the use of cardiac regeneration following chemotherapy-induced cardiomyopathy and a Phase II trial of cytotoxic T-lymphocytes in the treatment of BK and JC virus. Dr. Olson has institutional funding and extramural grant support.
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Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Stem Cell Transplantation, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
2007 | The Medical College of Georgia School of Medicine, Augusta, GA, USA, MD, Medical Doctor |
2003 | University of Georgia, Athens, GA, USA, BS, Biology, Minor in Religion |
Postgraduate Training
2010-2013 | Fellowship, Hematology and Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY |
2008-2010 | Residency, Internal Medicine, Baylor College of Medicine, Houston, TX |
2007-2008 | Internship, Internal Medicine, Baylor College of Medicine, Houston, TX |
2004-2004 | Research Fellowship, National Institute of Health, Bethesda, MD |
Board Certifications
2015 | Hematology |
2010 | Internal Medicine |
Honors & Awards
2012 | The Future of Stem Cell Transplantation, American Society of Hematology |
2012 | The Lymphoma Foundation, Mortimer J. Lacher Fellowship |
Selected Publications
Peer-Reviewed Articles
- Sanchez-Petitto G, Rezvani K, Daher M, Rafei H, Kebriaei P, Shpall EJ, Olson A. Umbilical Cord Blood Transplantation: Connecting Its Origin to Its Future. Stem Cells Transl Med 12(2):55-71, 2023. e-Pub 2023. PMID: 36779789.
- Greenbaum U, Yalniz FF, Srour SA, Rezvani K, Singh H, Olson A, Blumenschein G, Hong DS, Shpall EJ, Kebriaei P. Chimeric Antigen Receptor Therapy: How Are We Driving in Solid Tumors?. Biol Blood Marrow Transplant 26(10):1759-1769, 2020. e-Pub 2020. PMID: 32623078.
- Popat U, Mehta RS, Bassett R, Kongtim P, Chen J, Alousi AM, Anderlini P, Ciurea S, Hosing C, Jones R, Kebriaei P, Khouri I, Lindsay PA R, Nieto Y, Olson A, Oran B, Qazilbash MH, Rondon G, Shpall EJ, Verstovsek S, Andersson BS, Champlin RE. Optimizing the Conditioning Regimen for HCT in Myelofibrosis: Long-term Results of a Prospective Phase II Clinical Trial. Biology of Blood and Marrow Transplantation 26(8):1439-1445, 2020. PMID: 32438043.
- Mehta RS, Saliba RM, Cao K, Kaur I, Rezvani K, Chen J, Olson AL, Parmar S, Shah N, Marin D, Alousi A, Hosing C, Popat U, Kebriaei P, Champlin R, de Lima M, Skerrett D, Burke E, Shpall EJ, Oran B. Ex Vivo Mesenchymal Precursor Cell-Expanded Cord Blood Transplantation Following Reduced Intensity Conditioning Regimens Improves Time to Neutrophil Recovery. Biol Blood Marrow Transplant 23(8):1359-1366, 2017. e-Pub 2017. PMID: 28506845.
- Barker JN, Kurtzberg J, Ballen K, Boo M, Brunstein C, Cutler C, Horwitz M, Milano F, Olson AL, Spellman S, Wagner JE, Delaney C, Shpall E. Optimal Practices in Unrelated Donor Cord Blood Transplantation for Hematologic Malignancies. Biol Blood Marrow Transplant 23(6):882-896, 2017. e-Pub 2017. PMID: 28279825.
- Khan M, Adil SE, Olson AL. The role of mesenchymal stem cells in oncology and regenerative medicine. Future Oncol 13(9):821-831, 2017. e-Pub 2016. PMID: 27908206.
- Abudayyeh A, Hamdi A, Abdelrahim M, Lin H, Page VD, Rondon G, Andersson BS, Afrough A, Martinez CS, Tarrand JJ, Kontoyiannis DP, Marin D, Gaber AO, Oran B, Chemaly RF, Ahmed S, Abudayyeh I, Olson AL, Jones R, Popat U, Champlin RE, Shpall EJ, Rezvani K. Poor immune reconstitution is associated with symptomatic BK polyomavirus viruria in allogeneic stem cell transplant recipients. Transpl Infect Dis 19(1), 2017. e-Pub 2016. PMID: 27862740.
- Sarvaria A, Basar R, Mehta RS, Shaim H, Muftuoglu M, Khoder A, Sekine T, Gokdemir E, Kondo K, Marin D, Daher M, Alousi AM, Alsuliman A, Liu E, Oran B, Olson AL, Jones RB, Popat U, Hosing C, Champlin R, Shpall EJ, Rezvani K. IL-10+ regulatory B cells are enriched in cord blood and may play a role in protection against GVHD after cord blood transplantation. Blood 128(10):1346-61, 2016. e-Pub 2016. PMID: 27439912.
- Varma A, Saliba RM, Torres HA, Afrough A, Hosing C, Khouri IF, Nieto Y, Shah ND, Parmar S, Bashir Q, Ahmed S, Jones RB, Kebriaei P, Olson AL, Shpall EJ, Alousi AM, Qazilbash MH, Champlin RE, Popat U. Outcomes in hepatitis C virus seropositive lymphoma and myeloma patients after autologous stem cell transplantation. Bone Marrow Transplant 51(7):999-1001, 2016. e-Pub 2016. PMID: 26950376.
- Saliba RM, Rezvani K, Leen A, Jorgensen J, Shah N, Hosing C, Parmar S, Oran B, Olson AL, Mehta RS, Chemaly R, Saunders IM, Bollard CM, Shpall EJ. General and Virus-Specific Immune Cell Reconstitution Following Double Cord Blood Transplantation. Biol Blood Marrow Transplant 21(7):1284-90, 2015. e-Pub 2015. PMID: 25708219.
- Dahi PB, Perales MA, Devlin SM, Olson AL, Lubin M, Gonzales AM, Scaradavou A, Kernan NA, O'Reilly RJ, Giralt S, Jakubowski A, Koehne G, Papadopoulos EB, Ponce DM, Sauter C, Papanicolaou G, Barker JN. Incidence, nature and mortality of cytomegalovirus infection after double-unit cord blood transplant. Leuk Lymphoma 56(6):1-7, 2015. e-Pub 2014. PMID: 25224458.
- Olson AL, McNiece IK. Novel clinical uses for cord blood derived mesenchymal stromal cells. Cytotherapy 17(6):796-802, 2015. e-Pub 2015. PMID: 25819838.
- Thompson PA, Rezvani K, Hosing CM, Oran B, Olson AL, Popat UR, Alousi AM, Shah ND, Parmar S, Bollard C, Hanley P, Kebriaei P, Cooper L, Kellner J, McNiece IK, Shpall EJ. Umbilical cord blood graft engineering: challenges and opportunities. Bone Marrow Transplant 50 Suppl 2:S55-62, 2015. PMID: 26039209.
- Popat U, Mehta R, Rezvani K, Fox P, Kondo K, Marin D, McNiece I, Oran B, Hosing C, Olson AL, Parmar S, Shah N, Andreeff M, Kebriaei P, Kaur I, Yvon E, de Lima M, Cooper L, Tewari P, Champlin R, Nieto Y, Andersson B, Alousi A, Jones R, Qazilbash M, Bashir Q, Ciurea S, Ahmed S, Anderlini P, Bosque D, Bollard C, Molldrem J, Chen J, Rondon G, Thomas M, Miller L, Wolpe S, Simmons P, Robinson S, Zweidler-McKay P, and Shpall EJ.. Enforced fucosylation of cord blood hematopoietic cells accelerates neutrophil and platelet engraftment after transplantation. Blood 125(19):2885-92, 2015. e-Pub 2015.
- Munoz J, Shah N, Rezvani K, Hosing C, Bollard CM, Oran B, Olson AL, Popat U, Molldrem J, McNiece IK, Shpall EJ. Concise review: umbilical cord blood transplantation: past, present, and future. Stem Cells Transl Med 3(12):1435-43, 2014. e-Pub 2014. PMID: 25378655.
- Olson AL, Dahi PB, Zheng J, Devlin SM, Lubin M, Gonzales AM, Giralt SA, Perales MA, Papadopoulos EB, Ponce DM, Young JW, Kernan NA, Scaradavou A, O'Reilly RJ, Small TN, Papanicolaou G, Barker JN. Frequent human herpesvirus-6 viremia but low incidence of encephalitis in double-unit cord blood recipients transplanted without antithymocyte globulin. Biol Blood Marrow Transplant 20(6):787-93, 2014. e-Pub 2014. PMID: 24548875.
Other Articles
- Olson AL, Lehrman R, Devlin SM, Maloy M, Castro-Malaspina H, Giralt SA, Goldberg JD, O'Reilly RJ, Perales MA, Papadopoulos EB, & Jakubowski AA The Prognostic Significance of Peripheral Blood Mixed Chimerism After T-Cell Depleted Allogeneic Stem Cell Transplant. Biology of Blood and Marrow Transplantation 19(2):S301-302, 2013.
- Olson AL, Dahi P, J Zheng, Devlin SM, Lubin M, Gonzales AM, Giralt S, Ponce D, Kernan NA, Scaradavou A, Papanicolaou G, Barker JN HHV-6 Viremia is Frequent but the Incidence of Encephalitis is Low in Double-Unit Cord Blood Transplant Recipients Transplanted without ATG. Biology of Blood and Marrow Transplantation 19(2):S125, 2013.
- Dahi P, Olson AL, Devlin S, Lubin M, Gonzales A.M., Evans K., Scaradavou A., Kernan N., Small T, O'Reilly R, Giralt SA, Koehne G, Perales MA, Ponce D, Papanicolaou Z, & Barker JN Incidence, Nature, Risk Factors and Outcomes of Cytomegalovirus Infection After Double-Unit Cord Blood Transplantation. Biology of Blood and Marrow Transplantation 19(2):S344-S345, 2013.
- Olson AL, Devlin SM, Maloy M, Lehman R, Barker JN, Castro-Malaspina H, Giralt SA, Goldberg JH. D, O'Reilly RJ, Perales MA, Papadopoulos EB, Jakubowski A.A Bone marrow mixed chimerism is a risk factor for relapse after T-cell depleted allogeneic stem cell transplant. Blood 120(21):4145, 2012.
- Olson AL, Dahi P, Zheng J, Devlin SM, Lubin M, Gonzales AM, Giralt S, Ponce D, Kernan NA, Scaradavou A, Papanicolaou G, Barker JN HHV-6 Viremia is Frequent but the Incidence of Encephalitis is Low in Double-Unit Cord Blood Transplant Recipients Transplanted without ATG. Blood 120(21):459, 2012.
- Schwartzberg LS, Beeram M, Patnaik A, Tolcher AW, Itri L, Olson AL, Seidman AD Tesetaxel, an advanced-generation oral taxane, as first-line treatment in women with metastatic breast cancer. Journal of Clinical Oncology 29(15_suppl, TPS123-TPS123), 2011.
- Olson AL, Hortobagyi GN, Hahn KM Cervical and colorectal screening among breast cancer survivors followed in either a breast center of a breast survivorship clinic at The University of Texas M.D. Anderson Cancer Center. Journal of Clinical Oncology 27(15), 2009.
Abstracts
- Olson AL, Saliba R, Oran B, Chen J, Alousi A, Ahmad S, Bashir Q, Ciurea S, Hosing C, Jones R, Kebriaei P, Khouri I, Nieto Y, Parmar S, Shah N, Shpall EJ, Qazilbash M, Andersson B, Champlin R, Popat U. Cytogenetics and Blast Count Determine Outcomes Advanced AML. Biology of Blood and Marrow Transplantation, 2015.
- Ahmed S, Shpall E, Gulbis A, Jones R, Martinez C, Rondon G, Rezvani K, Oran B, Olson AL, Shah N, Parmar S, Popat U, Alousi A, Nieto Y, Hosing C, Bashir Q, Kebriaei P, Qazilbash M, Champlin R, Mulanovich V. Assessment of Incidence Toxoplasma Gondii Infection and Outcomes in Allogeneic Stem Cell Patients. American Society of Hematology, 2014.
- Oran B, Cao K, Saliba R, Hosing C, Popat U, de Lima M, Carmazzi Y, Alousi A, Kebriaei P, Nieto Y, Rondon G, Willis D, Shah N, Parmar S, Olson AL, Moore B, Champlin R, Rezvani K, Shpall E. Higher Allele Level HLA Matching Improves Prognostication after Double Umbilical Cord Blood (dUCB) Transplantation for Hematological Malignancies. American Soiety of Hematology, 2014.
- Popat U, Fox Patricia, Bassett R, Chen J, Valdez B, Kawedia J, Ahmed S, Alousi A, Bashir Q, Ciurea S, Hosing C, Jones R, Kebriaei P, Khouri I, Nieto Y, Olson AL, Oran B, Parmar S, Qazilbash M, Shah N, Shpall E, Andersson B, Champlin R. Myeloablative Timed Sequential Busulfan Is Safe in Older Patients. American Society of Hematology, 2014.
Book Chapters
- Olson AL and Shpall EJ. Chapter 11 – Cord Blood Cells for Clinical Use: Expansion and Manipulation. In: Cord Blood Stem Cells and Regenerative Medicine, 2015.
- Olson AL. Allogeneic Stem Cell Transplantation, Autologous Stem Cell Transplantation, Chronic Myelogenous Leukemia. In: PocketOncology. Lippincott Williams and Wilkins Publishers, 2014.
Grant & Contract Support
Title: | Mesenchymal Stem Cells as Tumor-Tropic Vehicles for Ovarian Cancer Treatment |
Funding Source: | NIH/NCI |
Role: | Collaborator |
Title: | Mesenchymal Stem Cells for Adriamycin Induced Cardiotoxicity |
Funding Source: | UTMDACC |
Role: | Principal Investigator |
Title: | A Phase II Trial of Mesenchymal Stem Cells for Treatment of Acute Respiratory Distress |
Funding Source: | Katz Foundation |
Role: | Co-Investigator |
Title: | TMC Regenerative Medicine Consortium Projects |
Funding Source: | Texas Medical Center |
Role: | Steward |
Title: | Phase 1 Study to Determine the Effects of Mesenchymal Stem Cells Secreting Interferon Beta in Patients with Advanced Ovarian Cancer |
Funding Source: | UTMDACC (HICRSP-MEBRS) |
Role: | Principal Investigator |
Patient Reviews
CV information above last modified September 11, 2023