Amol J. Ghia, M.D.
Department of Radiation Oncology, Division of Radiation Oncology
About Dr. Ghia
Dr. Amol Ghia is an Associate Professor and Director of Spine Stereotactic Radiosurgery (SSRS) in the Central Nervous System (CNS) Service of the Department of Radiation Oncology at The University of Texas M.D. Anderson Cancer Center (MDACC). Dr. Ghia treats patients with primary as well as metastatic disease of the brain and spine using advanced radiation tools such as Gamma Knife, proton radiation and image-guided stereotactic radiation personalized to an individual patient’s clinical case. Spine stereotactic radiosurgery is an emerging non-invasive ablative treatment option alternative to surgery for patients with disease in the spine. As Director of the Spine Stereotactic Radiosurgery program, he oversees the clinical and academic operations of the SSRS program which includes serving as the Principle Investigator of two randomized institutional trials.
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Director Spine Stereotactic Radiosurgery, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
2004 | University of Colorado Health Sciences Center, Denver, CO, USA, MD, Medicine |
2000 | Duke University, Durham, NC, USA, BS, BS with Distinction in Psychology and Neuroscience Certificate |
Postgraduate Training
2008-2012 | Clinical Residency, Radiation Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT |
2006-2008 | Research Fellowship, Physician Scientist Training Grant (T-32), University of Wisconsin Cancer Center, Madison, WI |
2004-2006 | Clinical Residency, Neurosurgery, University of Wisconsin, Madison, WI |
Experience & Service
Academic Appointments
Assistant Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2012 - 2018
Administrative Appointments/Responsibilities
Cancer Network Team CNS Section Director, Department of Radiation Oncology, MDACC Radiation Oncology Cancer Network, Houston, TX, 2016 - 2019
Honors & Awards
2017 | Clinical Innovator Award - Fiscal Year 2017 Cycle, MD Anderson Cancer Center |
2014 | MD Anderson Clinical Trials Workshop for Junior Faculty, MD Anderson Cancer Center |
2011 | Roentgen Resident Research Award, Radiological Society of North America |
2010 | Young Oncologist Essay Award and Travel Grant, American Radium Society |
2007 | AACR-Eli Lilly Travel Award, AACR-NCI-EORTC International Conference |
2006 | Physician Scientist Training Program in Cancer Medicine (Grant T-32), University of Wisconsin Comprehensive Cancer Center |
2001 | Exceptional Summer Student Award, NINDS (NIH) |
2000 | Howard Hughes Fellowship and Forum for Neuroscience, Duke University |
2000 | Community Action Award (Lars Lyon Volunteer Service Award Dinner), Duke University |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Beckham TH, Rooney MK, McAleer MF, Ghia AJ, Tom MC, Perni S, McGovern S, Grosshans D, Chung C, Wang C, De B, Swanson T, Paulino A, Jiang W, Ferguson S, Patel CB, Li J, Yeboa DN. Hypofractionated radiotherapy for glioblastoma: A large institutional retrospective assessment of 2 approaches. Neurooncol Pract 11(3):266-274, 2024. e-Pub 2024. PMID: 38737610.
- Beckham TH, Rooney MK, Cifter G, Bernard V, McAleer MF, De BS, Tom MC, Perni S, Wang C, Swanson T, Tatsui CE, Alvarez-Breckenridge C, North R, Rhines LD, Tang C, Logothetis C, Amini B, Li J, Yeboa DN, Ghia AJ. Stereotactic radiosurgery for prostate cancer spine metastases: local control and fracture risk using a simultaneous integrated boost approach. J Neurosurg Spine:1-9. e-Pub 2024. PMID: 38875722.
- Ene CI, Abi Faraj C, Beckham TH, Weinberg JS, Andersen CR, Haider AS, Rao G, Ferguson SD, Alvarez-Brenkenridge CA, Kim BYS, Heimberger AB, McCutcheon IE, Prabhu SS, Wang CM, Ghia AJ, McGovern SL, Chung C, McAleer MF, Tom MC, Perni S, Swanson TA, Yeboa DN, Briere TM, Huse JT, Fuller GN, Lang FF, Li J, Suki D, Sawaya RE. Response of treatment-naive brain metastases to stereotactic radiosurgery. Nat Commun 15(1):3728, 2024. e-Pub 2024. PMID: 38697991.
- Wang C, Rooney MK, Alvarez-Breckenridge C, Beckham TH, Chung C, De BS, Ghia AJ, Grosshans D, Majd NK, McAleer MF, McGovern SL, North RY, Paulino AC, Perni S, Reddy JP, Rhines LD, Swanson TA, Tatsui CE, Tom MC, Yeboa DN, Li J. Outcomes and Pattern of Care for Spinal Myxopapillary Ependymoma in the Modern Era-A Population-Based Observational Study. Cancers (Basel) 16(11), 2024. e-Pub 2024. PMID: 38893133.
- Shanker MD, Cavazos AP, Li J, Beckham TH, Yeboa DN, Wang C, McAleer MF, Briere TM, Amini B, Tatsui CE, North RY, Alvarez-Breckenridge CA, Cezayirli PC, Rhines LD, Ghia AJ, Bishop AJ. Definitive single fraction spine stereotactic radiosurgery for metastatic sarcoma: Simultaneous integrated boost is associated with high tumor control and low vertebral fracture risk. Radiother Oncol 193:110119, 2024. e-Pub 2024. PMID: 38311030.
- Yadav D, Upadhyay R, Kumar VA, Chen MM, Johnson JM, Langshaw H, Curl BJ, Farhat M, Talpur W, Beckham TH, Yeboa DN, Swanson TA, Ghia AJ, Li J, Chung C. Additive Value of MR Simulation Prior to Chemoradiation in Evaluating Treatment Response and Pseudoprogression in High-Grade Gliomas. Pract Radiat Oncol. e-Pub 2024. PMID: 38685448.
- Ledbetter D, de Almeida R, Wu X, Naveh A, Patel CB, Gonzalez Q, Beckham TH, North R, Rhines L, Li J, Ghia A, Aten D, Tatsui C, Alvarez-Breckenridge C. Tumor treating fields suppress tumor cell growth and neurologic decline in models of spine metastases. JCI Insight. e-Pub 2024. PMID: 38512420.
- de Almeida RAA, Ghia AJ, Amini B, Wang C, Alvarez-Breckenridge CA, Li J, Rhines LD, Tom MC, North RY, Beckham TH, Tatsui CE. Quantification of MRI Artifacts in Carbon Fiber Reinforced Polyetheretherketone Thoracolumbar Pedicle Screw Constructs prior to Spinal Stereotactic Radiosurgery. Pract Radiat Oncol 14(2):103-111, 2024. e-Pub 2023. PMID: 37914081.
- Sherry AD, Maroongroge S, De B, Amini B, Conley AP, Bishop AJ, Wang C, Beckham T, Tom M, Briere T, Li J, Yeboa DN, McAleer MF, North R, Tatsui CE, Rhines LD, Ghia AJ. Management of chordoma and chondrosarcoma with definitive dose-escalated single-fraction spine stereotactic radiosurgery. J Neurooncol. e-Pub 2023. PMID: 37667065.
- Matsui JK, Allen PK, Perlow HK, Johnson JM, Paulino AC, McAleer MF, Fouladi M, Grosshans DR, Ghia AJ, Li J, Zaky WT, Chintagumpala MM, Palmer JD, McGovern SL. Prognostic factors for pediatric, adolescent, and young adult patients with non-DIPG grade 4 gliomas: a contemporary pooled institutional experience. J Neurooncol. e-Pub 2023. PMID: 37440097.
- Tang C, Sherry AD, Haymaker C, Bathala T, Liu S, Fellman B, Cohen L, Aparicio A, Zurita AJ, Reuben A, Marmonti E, Chun SG, Reddy JP, Ghia A, McGuire S, Efstathiou E, Wang J, Wang J, Pilie P, Kovitz C, Du W, Simiele SJ, Kumar R, Borghero Y, Shi Z, Chapin B, Gomez D, Wistuba I, Corn PG. Addition of Metastasis-Directed Therapy to Intermittent Hormone Therapy for Oligometastatic Prostate Cancer: The EXTEND Phase 2 Randomized Clinical Trial. JAMA Oncol 9(6):825-834, 2023. e-Pub 2023. PMID: 37022702.
- Florez MA, De B, Chapman BV, Prayongrat A, Thomas JG, Beckham TH, Wang C, Yeboa DN, Bishop AJ, Briere T, Amini B, Li J, Tatsui CE, Rhines LD, Ghia AJ. Safety and efficacy of salvage conventional re-irradiation following stereotactic radiosurgery for spine metastases. Radiat Oncol J 41(1):12-22, 2023. e-Pub 2023. PMID: 37013414.
- Florez MA, De B, Cavazos A, Farooqi A, Beckham TH, Wang C, Yeboa DN, Bishop AJ, McAleer MF, Briere T, Amini B, Li J, Tatsui CE, Rhines LD, Ghia AJ. Safety and Efficacy of Dose-Escalated Radiation Therapy With a Simultaneous Integrated Boost for the Treatment of Spinal Metastases. Pract Radiat Oncol 13(1):e7-e13, 2023. e-Pub 2022. PMID: 36604100.
- Ozkizilkaya HI, Johnson JM, O'Brien BJ, McCutcheon IE, Prabhu SS, Ghia AJ, Fuller GN, Huse JT, Ballester LY. Intracranial mesenchymal tumor, FET::CREB fusion-positive in the lateral ventricle. Neurooncol Adv 5(1):vdad026, 2023. e-Pub 2023. PMID: 37051329.
- Kowalchuk R, Mullikin TC, Breen W, Gits HC, Florez M, De B, Harmsen WS, Rose PS, Siontis BL, Costello BA, Morris JM, Lucido JJ, Olivier KR, Stish B, Laack NN, Park S, Owen D, Ghia AJ, Brown PD, Merrell KW. Development and validation of a unifying pre-treatment decision tool for intracranial and extracranial metastasis-directed radiotherapy. Front Oncol 13:1095170, 2023. e-Pub 2023. PMID: 37051531.
- McGovern SL, Luo D, Johnson J, Nguyen K, Li J, McAleer MF, Yeboa D, Grosshans DR, Ghia AJ, Chung C, Bishop AJ, Song J, Thall PF, Brown PD, Mahajan A. A Prospective Study of Conventionally Fractionated Dose Constraints for Reirradiation of Primary Brain Tumors in Adults. Pract Radiat Oncol 13(3):231-238, 2023. e-Pub 2022. PMID: 36596356.
- De B, Venkatesan AM, Msaouel P, Ghia AJ, Li J, Yeboa DN, Nguyen QN, Bishop AJ, Jonasch E, Shah AY, Campbell MT, Wang J, Zurita-Saavedra AJ, Karam JA, Wood CG, Matin SF, Tannir NM, Tang C. Definitive Radiotherapy for Extracranial Oligoprogressive Metastatic Renal Cell Carcinoma as a Strategy to Defer Systemic Therapy Escalation. BJU Int 129(5):610-620, 2022. e-Pub 2021. PMID: 34228889.
- Dunne EM, Lo SS, Liu MC, Bergman A, Kosztyla R, Chang EL, Chang UK, Chao ST, Dea N, Faruqi S, Ghia AJ, Redmond KJ, Soltys SG, Sahgal A. Thecal Sac Contouring as a Surrogate for the Cauda Equina and Intracanal Spinal Nerve Roots for Spine Stereotactic Body Radiation Therapy (SBRT): Contour Variability and Recommendations for Safe Practice. Int J Radiat Oncol Biol Phys 112(1):114-120, 2022. e-Pub 2021. PMID: 34454046.
- Brown PD, Chung C, Liu DD, McAvoy S, Grosshans D, Al Feghali K, Mahajan A, Li J, McGovern SL, McAleer MF, Ghia AJ, Sulman EP, Penas-Prado M, de Groot JF, Heimberger AB, Wang J, Armstrong TS, Gilbert MR, Guha-Thakurta N, Wefel JS. A Prospective Phase II Randomized Trial of Proton Radiotherapy vs. Intensity Modulated Radiotherapy for Patients with Newly Diagnosed Glioblastoma. Neuro Oncol 23(8):1337-1347, 2021. e-Pub 2021. PMID: 33647972.
- Ghia AJ, Guha-Thakurta N, Song J, Thall P, Briere TM, Settle SH, Sharp HJ, Li J, McAleer M, Chang EL, Tatsui CE, Brown PD, Rhines LD. Phase 1 study of spinal cord constraint relaxation with single session spine stereotactic radiosurgery in the primary management of patients with inoperable, previously irradiated metastatic epidural spinal cord compression. N Am Spine Soc J 6:100066, 2021. e-Pub 2021. PMID: 35141631.
- Mohan R, Liu AY, Brown PD, Mahajan A, Dinh J, Chung C, McAvoy S, McAleer MF, Lin SH, Li J, Ghia AJ, Zhu C, Sulman EP, de Groot JF, Heimberger AB, McGovern SL, Grassberger C, Shih H, Ellsworth S, Grosshans DR. Proton Therapy Reduces the Likelihood of High-Grade Radiation-Induced Lymphopenia in Glioblastoma Patients: Phase II Randomized Study of Protons vs. Photons. Neuro Oncol 23(2):284-294, 2021. e-Pub 2020. PMID: 32750703.
- Al Feghali KA, Randall JW, Liu DD, Wefel JS, Brown PD, Grosshans DR, McAvoy SA, Farhat MA, Li J, McGovern SL, McAleer MF, Ghia AJ, Paulino AC, Sulman EP, Penas-Prado M, Wang J, de Groot J, Heimberger AB, Armstrong TS, Gilbert MR, Mahajan A, Guha-Thakurta N, Chung C. Phase II trial of proton therapy versus photon IMRT for GBM: secondary analysis comparison of progression-free survival between RANO versus clinical assessment. Neurooncol Adv 3(1):vdab073, 2021. e-Pub 2021. PMID: 34337411.
- Diao K, Song J, Thall PF, McGinnis GJ, Boyce-Fappiano D, Amini B, Brown PD, Yeboa DN, Bishop AJ, Li J, Briere TM, Tatsui CE, Rhines LD, Chang EL, Ghia AJ. Low risk of radiation myelopathy with relaxed spinal cord dose constraints in de novo, single fraction spine stereotactic radiosurgery. Radiother Oncol 152:49-55, 2020. e-Pub 2020. PMID: 32745668.
- Gjyshi O, Boyce-Fappiano D, Pezzi TA, Ludmir EB, Xiao L, Kaseb A, Amini B, Yeboa DN, Bishop AJ, Li J, Rhines LD, Tatsui CE, Briere TM, Ghia AJ. Spine stereotactic radiosurgery for metastases from hepatobiliary malignancies: patient selection using PRISM scoring. J Neurooncol 148(2):327-334, 2020. e-Pub 2020. PMID: 32358642.
- Dunne EM, Sahgal A, Lo SS, Bergman A, Kosztyla R, Dea N, Chang EL, Chang UK, Chao ST, Faruqi S, Ghia AJ, Redmond KJ, Soltys SG, Liu MC. International consensus recommendations for target volume delineation specific to sacral metastases and spinal stereotactic body radiation therapy (SBRT). Radiother Oncol 145:21-29, 2020. e-Pub 2019. PMID: 31874346.
- Vega RA, Ghia AJ, Tatsui CE. Percutaneous Hybrid Therapy for Spinal Metastatic Disease: Laser Interstitial Thermal Therapy and Spinal Stereotactic Radiosurgery. Neurosurg Clin N Am 31(2):211-219, 2020. e-Pub 2020. PMID: 32147012.
- Boyce-Fappiano D, Ning MS, Thaker NG, Pezzi TA, Gjyshi O, Mesko S, Anakwenze C, Olivieri ND, Guzman AB, Incalcaterra JR, Tang C, McAleer MF, Herman J, Ghia AJ. Time-Driven Activity-Based Cost Analysis of Radiation Treatment Options for Spinal Metastases. JCO Oncol Pract 16(3):JOP1900480, 2020. e-Pub 2019. PMID: 31765268.
- Evans LT, DeMonte F, Grosshans DR, Ghia AJ, Habib A, Raza SM. Salvage Therapy for Local Progression following Definitive Therapy for Skull Base Chordomas: Is There a Role of Stereotactic Radiosurgery?. J Neurol Surg B Skull Base 81(1):97-106, 2020. e-Pub 2019. PMID: 32021756.
- Boyce-Fappiano D, Gjyshi O, Pezzi TA, Allen PK, Solimman M, Taku N, Bernstein MB, Cabanillas ME, Amini B, Tatsui CE, Rhines LD, Wang XA, Briere TM, Yeboa DN, Bishop AJ, Li J, Ghia AJ. Spine stereotactic radiosurgery for metastatic thyroid cancer: a single-institution experience. J Neurosurg Spine:1-9. e-Pub 2020. PMID: 32059183.
- de Almeida Bastos DC, Everson RG, de Oliveira Santos BF, Habib A, Vega RA, Oro M, Rao G, Li J, Ghia AJ, Bishop AJ, Yeboa DN, Amini B, Rhines LD, Tatsui CE. A comparison of spinal laser interstitial thermotherapy with open surgery for metastatic thoracic epidural spinal cord compression. J Neurosurg Spine:1-9. e-Pub 2020. PMID: 31899882.
- Grant SR, Brown PD, Tatsui CE, Ghia AJ. Seed, soil, and spine stereotactic radiosurgery: A unique case of metastatic dissemination. J Radiosurg SBRT 6(4):325-328, 2020. PMID: 32185094.
- Ning MS, Deegan BJ, Ho JC, Chapman BV, Bishop AJ, Allen PK, Tannir NM, Amini B, Briere TM, Wang XA, Tatsui CE, Rhines LD, Brown PD, Li J, Ghia AJ. Low incidence of late failure and toxicity after spine stereotactic radiosurgery: Secondary analysis of phase I/II trials with long-term follow-up. Radiother Oncol 138:80-85, 2019. e-Pub 2019. PMID: 31252298.
- Ludmir EB, Mahajan A, Ahern V, Ajithkumar T, Alapetite C, Bernier-Chastagner V, Bindra RS, Bishop AJ, Bolle S, Brown PD, Carrie C, Chalmers AJ, Chang EL, Chung C, Dieckmann K, Esiashvili N, Gandola L, Ghia AJ, Gondi V, Grosshans DR, Harrabi SB, Horan G, Indelicato DJ, Jalali R, Janssens GO, Krause M, Laack NN, Laperriere N, Laprie A, Li J, Marcus KJ, McGovern SL, Merchant TE, Merrell KW, Padovani L, Parkes J, Paulino AC, Schwarz R, Shih HA, Souhami L, Sulman EP, Taylor RE, Thorp N, Timmermann B, Wheeler G, Wolden SL, Woodhouse KD, Yeboa DN, Yock TI, Kortmann RD, McAleer MF. Assembling the brain trust: the multidisciplinary imperative in neuro-oncology. Nat Rev Clin Oncol 16(8):521-522, 2019. PMID: 31150024.
- Kruser TJ, Bosch WR, Badiyan SN, Bovi JA, Ghia AJ, Kim MM, Solanki AA, Sachdev S, Tsien C, Wang TJC, Mehta MP, McMullen KP. NRG brain tumor specialists consensus guidelines for glioblastoma contouring. J Neurooncol 143(1):157-166, 2019. e-Pub 2019. PMID: 30888558.
- Mesko S, Deegan BJ, D'Souza NM, Ghia AJ, Chapman BV, Amini B, McAleer MF, Wang XA, Brown PD, Tatsui CE, Rhines L, Li J. Spine Stereotactic Radiosurgery for Metastatic Pheochromocytoma. Cureus 11(5):e4742, 2019. e-Pub 2019. PMID: 31355101.
- Wang X, Yang J, Zhao Z, Luo D, Court L, Zhang Y, Weksberg D, Brown PD, Li J, Ghia AJ. Dosimetric impact of esophagus motion in single fraction spine stereotactic body radiotherapy. Phys Med Biol 64(11):115010, 2019. e-Pub 2019. PMID: 31018191.
- Farooqi A, Bishop AJ, Narang S, Allen PK, Li J, McAleer MF, Tatsui CE, Rhines LD, Amini B, Wang XA, Ghia AJ. Outcomes after hypofractionated dose-escalation using a simultaneous integrated boost technique for treatment of spine metastases not amenable to stereotactic radiosurgery. Pract Radiat Oncol 9(2):e142-e148, 2019. e-Pub 2018. PMID: 30385151.
- Yeboa DN, Liao KP, Guadagnolo BA, Rao G, Bishop A, Chung C, Li J, Tatsui CE, Rhines LD, Ferguson S, Paulino AC, Ghia AJ. National patterns of care in the management of WHO grade II and III spinal ependymomas. World Neurosurg. e-Pub 2019. PMID: 30641236.
- Ayala GB, Doan KA, Ko HJ, Park PK, Santiago ED, Kuruvila SJ, Ghia AJ, Briere TM, Wen Z. IMRT planning parameter optimization for spine stereotactic radiosurgery. Med Dosim 44(4):303-308, 2019. e-Pub 2018. PMID: 30514600.
- Ghia AJ, Guha-Thakurta N, Hess K, Yang JN, Settle SH, Sharpe HJ, Li J, McAleer M, Chang EL, Tatsui CE, Brown PD, Rhines LD. Phase 1 study of spinal cord constraint relaxation with single session spine stereotactic radiosurgery in the primary management of patients with inoperable, previously unirradiated metastatic epidural spinal cord compression. Int J Radiat Oncol Biol Phys 102(5):1481-1488, 2018. e-Pub 2018. PMID: 30099131.
- Phan J, Pollard C, Brown PD, Guha-Thakurta N, Garden AS, Rosenthal DI, Fuller CD, Frank SJ, Gunn GB, Morrison WH, Ho JC, Li J, Ghia AJ, Yang JN, Luo D, Wang HC, Su SY, Raza SM, Gidley PW, Hanna EY, DeMonte F. Stereotactic radiosurgery for trigeminal pain secondary to recurrent malignant skull base tumors. J Neurosurg 130(3):1-10, 2018. e-Pub 2018. PMID: 29701557.
- Bernard V, Bishop AJ, Allen PK, Amini B, Wang XA, Li J, Tatsui CE, Rhines LD, Brown PD, Ghia AJ. Heterogeneity in Treatment Response of Spine Metastases to Spine Stereotactic Radiosurgery Within "Radiosensitive" Subtypes. Int J Radiat Oncol Biol Phys 99(5):1207-1215, 2017. e-Pub 2017. PMID: 29029886.
- Thomas JG, Al-Holou WN, de Almeida Bastos DC, Ghia AJ, Li J, Bishop AJ, Amini B, Rhines LD, Tatsui CE. A novel use of the intraoperative MRI for metastatic spine tumors: laser interstitial thermal therapy for percutaneous treatment of epidural metastatic spine disease. Neurosurg Clin N Am 28(4):513-524, 2017. e-Pub 2017. PMID: 28917280.
- Bishop AJ, Tao R, Guadagnolo BA, Allen PK, Rebueno NC, Wang XA, Amini B, Tatsui CE, Rhines LD, Li J, Chang EL, Brown PD, Ghia AJ. Spine stereotactic radiosurgery for metastatic sarcoma: patterns of failure and radiation treatment volume considerations. J Neurosurg Spine 27(3):1-9, 2017. e-Pub 2017. PMID: 28644075.
- Wang X, Zhao Z, Luo D, Yang JN, Yang J, Chang EL, Brown PD, Li J, McAleer MF, Ghia AJ. Submillimeter alignment of more than three contiguous vertebrae in spinal SRS/SBRT with 6-degree couch. J Appl Clin Med Phys 18(5):225-236, 2017. e-Pub 2017. PMID: 28786235.
- Mahajan A, Ahmed S, McAleer MF, Weinberg JS, Li J, Brown P, Settle S, Prabhu SS, Lang FF, Levine N, McGovern S, Sulman E, McCutcheon IE, Azeem S, Cahill D, Tatsui C, Heimberger AB, Ferguson S, Ghia A, Demonte F, Raza S, Guha-Thakurta N, Yang J, Sawaya R, Hess KR, Rao G. Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: a single-centre, randomised, controlled, phase 3 trial. Lancet Oncol 18(8):1040-1048, 2017. e-Pub 2017. PMID: 28687375.
- Fang P, Jiang W, Allen P, Glitza I, Guha N, Hwu P, Ghia A, Phan J, Mahajan A, Tawbi H, Li J. Radiation necrosis with stereotactic radiosurgery combined with CTLA-4 blockade and PD-1 inhibition for treatment of intracranial disease in metastatic melanoma. J Neurooncol 133(3):595-602, 2017. e-Pub 2017. PMID: 28500560.
- Tatsui CE, Nascimento CNG, Suki D, Amini B, Li J, Ghia AJ, Thomas JG, Stafford RJ, Rhines LD, Cata JP, Kumar AJ, Rao G. Image guidance based on MRI for spinal interstitial laser thermotherapy: technical aspects and accuracy. J Neurosurg Spine 26(5):605-612, 2017. e-Pub 2017. PMID: 28186470.
- Redmond KJ, Robertson S, Lo SS, Soltys SG, Ryu S, McNutt T, Chao ST, Yamada Y, Ghia A, Chang EL, Sheehan J, Sahgal A. Consensus Contouring Guidelines for Postoperative Stereotactic Body Radiation Therapy for Metastatic Solid Tumor Malignancies to the Spine. Int J Radiat Oncol Biol Phys 97(1):64-74, 2017. e-Pub 2016. PMID: 27843035.
- Jensen G, Tang C, Hess KR, Bishop AJ, Pan HY, Li J, Yang JN, Tannir NM, Amini B, Tatsui C, Rhines L, Brown PD, Ghia AJ. Internal validation of the prognostic index for spine metastasis (PRISM) for stratifying survival in patients treated with spinal stereotactic radiosurgery. J Radiosurg SBRT 5(1):25-34, 2017. PMID: 29296460.
- Tatsui CE, Lee SH, Amini B, Rao G, Suki D, Oro M, Brown PD, Ghia AJ, Bhavsar S, Popat K, Rhines LD, Stafford RJ, Li J. Spinal Laser Interstitial Thermal Therapy: A Novel Alternative to Surgery for Metastatic Epidural Spinal Cord Compression. Neurosurgery 79 Suppl 1:S73-S82, 2016. PMID: 27861327.
- Tatsui CE, Belsuzarri TA, Oro M, Rhines LD, Li J, Ghia AJ, Amini B, Espinoza H, Brown PD, Rao G. Percutaneous surgery for treatment of epidural spinal cord compression and spinal instability: technical note. Neurosurg Focus 41(4):E2, 2016. PMID: 27690655.
- Bernstein MB, Chang EL, Amini B, Pan H, Cabanillas M, Wang XA, Allen PK, Rhines LD, Tatsui C, Li J, Brown PD, Ghia AJ. Spine stereotactic radiosurgery for patients with metastatic thyroid cancer - Secondary analysis of Phase I/II trials. Thyroid 26(9):1269-75, 2016. e-Pub 2016. PMID: 27334245.
- Ho JC, Tang C, Deegan BJ, Allen PK, Jonasch E, Amini B, Wang XA, Li J, Tatsui CE, Rhines LD, Brown PD, Ghia AJ. The use of spine stereotactic radiosurgery for oligometastatic disease. J Neurosurg Spine 25(2):239-47, 2016. e-Pub 2016. PMID: 27035507.
- Tao R, Bishop AJ, Brownlee Z, Allen PK, Settle SH, Chang EL, Wang X, Amini B, Tannir NM, Tatsui C, Rhines LD, Brown PD, Ghia AJ. Stereotactic Body Radiation Therapy for Spinal Metastases in the Postoperative Setting: A Secondary Analysis of Mature Phase 1-2 Trials. Int J Radiat Oncol Biol Phys 95(5):1405-13, 2016. e-Pub 2016. PMID: 27209509.
- Ho JC, Luo D, Guha-Thakurta N, Ferguson SD, Ghia AJ, Yang JN, Brown PD, Voong KR. Gamma Knife Stereotactic Radiosurgery for Brain Metastases Using Only 3 Pins. Neurosurgery 78(6):877-82, 2016. e-Pub 2015. PMID: 26488329.
- Wang X, Zhao Z, Yang J, Yang J, McAleer M, Brown P, Li J, Ghia AJ. SU-F-T-642: Sub Millimeter Accurate Setup of More Than Three Vertebrae in Spinal SBRT with 6D Couch. Med Phys 43(6):3611-3612, 2016. PMID: 28046323.
- Yang J, Wang X, Zhao Z, Yang J, Zhang Y, Court L, Li J, Brown P, Ghia A. SU-F-J-128: Dosimetric Impact of Esophagus Motion in Spine Stereotactic Body Radiotherapy. Med Phys 43(6):3436, 2016. PMID: 28048271.
- Ghia AJ, Chang EL, Bishop AJ, Pan HY, Boehling NS, Amini B, Allen PK, Li J, Rhines LD, Tannir NM, Tatsui CE, Brown PD, Yang JN. Single-fraction versus multifraction spinal stereotactic radiosurgery for spinal metastases from renal cell carcinoma: secondary analysis of Phase I/II trials. J Neurosurg Spine 24(5):1-8, 2016. e-Pub 2016. PMID: 26799117.
- Ghia AJ, Rebueno NC, Li J, Brown PD, Rhines LD, Tatsui CE. The use of image guided laser interstitial thermotherapy to supplement spine stereotactic radiosurgery to manage metastatic epidural spinal cord compression: Proof of concept and dosimetric analysis. Pract Radiat Oncol 6(2):e35-8, 2016. e-Pub 2015. PMID: 26577007.
- Amini B, Beaman CB, Madewell JE, Allen PK, Rhines LD, Tatsui CE, Tannir NM, Li J, Brown PD, Ghia AJ. Osseous Pseudoprogression in Vertebral Bodies Treated with Stereotactic Radiosurgery: A Secondary Analysis of Prospective Phase I/II Clinical Trials. AJNR Am J Neuroradiol 37(2):387-92, 2016. e-Pub 2015. PMID: 26494690.
- Lee SH, Tatsui CE, Ghia AJ, Amini B, Li J, Zavarella SM, Tannir NM, Brown PD, Rhines LD. Can the spinal instability neoplastic score prior to spinal radiosurgery predict compression fractures following stereotactic spinal radiosurgery for metastatic spinal tumor?: a post hoc analysis of prospective phase II single-institution trials. J Neurooncol 126(3):509-17, 2016. e-Pub 2015. PMID: 26643804.
- Weksberg DC, Yang JN, Tam AL, Li J, Wang XA, Zhao Z, McRae SE, Settle SH, Rhines LD, Chang EL, Brown PD, Ghia AJ. Prospective validation of treatment accuracy using implanted fiducial markers for spinal stereotactic body radiation therapy. J Radiosurg SBRT 4(1):7-14, 2016. PMID: 29296421.
- Wang X, Ghia AJ, Zhao Z, Yang J, Luo D, Briere TM, Pino R, Li J, McAleer MF, Weksberg DC, Chang EL, Brown PD, Yang JN. Prospective evaluation of target and spinal cord motion and dosimetric changes with respiration in spinal stereotactic body radiation therapy utilizing 4-D CT. J Radiosurg SBRT 4(3):165-176, 2016. PMID: 29296444.
- Grossberg A, Zhao Z, Walker G, Tsai J, Wang X, Lang F, Phan J, Ghia A, McGovern S, Mahajan A, Brown P, McAleer MF, Li J. Dose painting with Gamma Knife: Two techniques for delivering different doses to areas of recurrent or residual tumor after resection of brain metastases. Pract Radiat Oncol 5(6):390-7, 2015. e-Pub 2015. PMID: 26412338.
- Tatsui CE, Stafford RJ, Li J, Sellin JN, Amini B, Rao G, Suki D, Ghia AJ, Brown P, Lee SH, Cowles CE, Weinberg JS, Rhines LD. Utilization of laser interstitial thermotherapy guided by real-time thermal MRI as an alternative to separation surgery in the management of spinal metastasis. J Neurosurg Spine 23(4):400-11, 2015. e-Pub 2015. PMID: 26140398.
- Tang C, Hess K, Bishop AJ, Pan HY, Christensen EN, Yang JN, Tannir N, Amini B, Tatsui C, Rhines L, Brown P, Ghia A. Creation of a Prognostic Index for Spine Metastasis to Stratify Survival in Patients Treated With Spinal Stereotactic Radiosurgery: Secondary Analysis of Mature Prospective Trials. Int J Radiat Oncol Biol Phys 93(1):118-25, 2015. e-Pub 2015. PMID: 26130231.
- Bishop AJ, Tao R, Rebueno NC, Christensen EN, Allen PK, Wang XA, Amini B, Tannir NM, Tatsui CE, Rhines LD, Li J, Chang EL, Brown PD, Ghia AJ. Outcomes for Spine Stereotactic Body Radiation Therapy and an Analysis of Predictors of Local Recurrence. Int J Radiat Oncol Biol Phys 92(5):1016-26, 2015. e-Pub 2015. PMID: 26025777.
- Edson MA, Fuller GN, Allen PK, Levine NB, Ghia AJ, Mahajan A, Brown PD, DeMonte F, Li J. Outcomes after surgery and radiotherapy for papillary tumor of the pineal region. World Neurosurg 84(1):76-81, 2015. e-Pub 2015. PMID: 25749579.
- Voong KR, Farnia B, Wang Q, Luo D, McAleer MF, Rao G, Guha-Thakurta N, Likhacheva A, Ghia AJ, Brown PD, Li J. Gamma knife stereotactic radiosurgery in the treatment of brainstem metastases: The MD Anderson experience. Neurooncol Pract 2(1):40-47, 2015. e-Pub 2015. PMID: 26034640.
- Farnia B, Allen PK, Brown PD, Khatua S, Levine NB, Li J, Penas-Prado M, Mahajan A, Ghia AJ. Clinical Outcomes and Patterns of Failure in Pineoblastoma: A 30-year Single Institution Retrospective Review. World Neurosurg 82(6):1232-41, 2014. e-Pub 2014. PMID: 25045788.
- Pan HY, Allen PK, Wang XS, Chang EL, Rhines LD, Tatsui CE, Amini B, Wang XA, Tannir NM, Brown PD, Ghia AJ. Incidence and Predictive Factors of Pain Flare After Spine Stereotactic Body Radiation Therapy: Secondary Analysis of Phase 1/2 Trials. Int J Radiat Oncol Biol Phys 90(4):870-6, 2014. e-Pub 2014. PMID: 25227497.
- Ahmed KA, Allen PK, Mahajan A, Brown PD, Ghia AJ. Astroblastomas: a SEER based patterns of care analysis. World Neurosurg 82(1-2):e291-e297, 2014. e-Pub 2013. PMID: 24141003.
- Ghia AJ, Tward JD, Anker CJ, Boucher KM, Jensen RL, Shrieve DC. Radiosurgery for melanoma brain metastases: the impact of hemorrhage on local control. J Radiosurg SBRT 3(1):43-50, 2014. PMID: 29296384.
- Wagner AE, Chen A, Anker CJ, Tward JD, Ghia AJ, Jensen RL, Shrieve DC. Stereotactic radiosurgery for a single brain metastasis: factors impacting control. J Radiosurg SBRT 3(2):111-122, 2014. PMID: 29296392.
- Ghia AJ, Mahajan A, Allen PK, Armstrong TS, Lang FF, Gilbert MR, Brown PD. Supratentorial gross-totally resected non-anaplastic ependymoma: population based patterns of care and outcomes analysis. J Neurooncol 115(3):513-20, 2013. e-Pub 2013. PMID: 24085643.
- Ghia AJ, Chang EL, Allen PK, Mahajan A, Penas-Prado M, McCutcheon IE, Brown PD. Intracranial hemangiopericytoma: patterns of failure and the role of radiation therapy. Neurosurgery 73(4):624-30; discussion 630-1, 2013. e-Pub 2013. PMID: 23839520.
- Wagner AE, Pappas L, Ghia AJ, Gaffney DK. Impact of tumor size on survival in cancer of the cervix and validation of stage IIA1 and IIA2 subdivisions. Gynecol Oncol 129(3):517-21, 2013. e-Pub 2013. PMID: 23528928.
- Ghia AJ, Allen PK, Mahajan A, Penas-Prado M, McCutcheon IE, Brown PD. Intracranial hemangiopericytoma and the role of radiation therapy: a population based analysis. Neurosurgery 72(2):203-9, 2013. e-Pub 2012. PMID: 23149953.
- Ghia AJ, Gonzalez VJ, Tward JD, Stroup AM, Pappas L, Gaffney DK. Primary vaginal cancer and chemoradiotherapy: a patterns-of-care analysis. Int J Gynecol Cancer 21(2):378-384, 2011. PMID: 21270620.
- Ghia AJ, Neeley ES, Gaffney DK. Postoperative radiotherapy use and patterns of care analysis for node positive or parametria positive cervical cancer. Gynecol Oncol 119(3):411-416, 2010. e-Pub 2010. PMID: 20817225.
- Ghia AJ, Shrieve DC, Tward JD. Adjuvant radiotherapy use and patterns of care analysis for margin-positive prostate adenocarcinoma with extracapsular extension: postprostatectomy adjuvant radiotherapy: a SEER analysis. Urology 76(5):1169-1174, 2010. e-Pub 2010. PMID: 20709371.
- Gondi V, Tome WA, Marsh J, Struck A, Ghia A, Turian JV, Bentzen SM, Kuo JS, Khuntia D, Mehta MP. Estimated risk of perihippocampal disease progression after hippocampal avoidance during whole-brain radiotherapy: safety profile for RTOG 0933. Radiother Oncol 95(3):327-331, 2010. e-Pub 2010. PMID: 20392503.
- Li C, Iida M, Dunn EF, Ghia AJ, Wheeler DL. Nuclear EGFR contributes to acquired resistance to cetuximab. Oncogene 28(43):3801-3813, 2009. e-Pub 2009. PMID: 19684613.
- Kruser TJ, Armstrong EA, Ghia AJ, Huang S, Wheeler DL, Radinsky R, Freeman DJ, Harari PM. Augmentation of radiation response by panitumumab in models of upper aerodigestive tract cancer. Int J Radiat Oncol Biol Phys 72(2):534-542, 2008. PMID: 18793955.
- Ghia A, Tomé WA, Thomas S, Cannon G, Khuntia D, Kuo JS, Mehta MP. Distribution of brain metastases in relation to the hippocampus: implications for neurocognitive functional preservation. Int J Radiat Oncol Biol Phys 68(4):971-977, 2007. e-Pub 2007. PMID: 17446005.
- White AM, Ghia AJ, Levin ED, Swartzwelder HS. Binge pattern ethanol exposure in adolescent and adult rats: differential impact on subsequent responsiveness to ethanol. Alcohol Clin Exp Res 24(8):1251-1256, 2000. PMID: 10968665.
Editorials
- Ghia AJ, Sulman EP. Effect of tumor subtype on survival and the graded prognostic assessment for patients with breast cancer and brain metastases. Breast Diseases: A Year Book Quarterly 24(2):175-176, 2013.
- Ghia AJ. Predicting Survival in Women With Breast Cancer and Brain Metastasis: a Nomogram Outperforms Current Survival Prediction Models. Breast Diseases: A Year Book Quarterly 24(1), 2013.
- Ghia AJ. Salvage Stereotactic Radiosurgery for Breast Cancer Brain Metastases: Outcomes and Prognostic Factors. Breast Diseases: A Year Book Quarterly 23(4):354-355, 2012.
Abstracts
- Farooqi A, Narang S, Li J, McAleer MF, Tatsui CE, Rhines LD, Wang XA, Bishop A, Ghia AJ. Early outcomes of a novel hypofractionated dose escalated spine simultaneous integrated boost technique (SSIB) for treatment of metastatic lesions not amenable for spine stereotactic radiosurgery. International Journal of Radiation Oncology, Biology and Physics, 2017.
- Ghia AJ, Guha-Thakurta N, Hess K, Yang J, Settle S, Sharp H, Li J, McAleer MF, Tatsui CE, Chang EL, Brown PD, Rhines LD. Phase I study of spinal cord constraint relaxation with single session spine stereotactic radiosurgery in the primary management of patients with inoperable, previously unirradiated metastatic epidural spinal cord compression (MESCC). International Journal of Radiation Oncology, Biology and Physics, 2017.
- Deegan B, Ho J, Allen P, Jonasch E, Amini B, Wang X, Tatsui C, Rhines L, Li J, Brown P, Ghia AJ. Toxicity profile of spine stereotactic radiosurgery amongst long-term survivors. ASTRO's 58th Annual Meeting, 2016.
- Christensen, E, Klawikowski S, Garg A, McAleer M, Rhines L, Yang J, Brown P, Chang E, Settle S, Ghia AJ. Outcomes in stereotactic body radiotherapy for spinal tumors: an updated MD Anderson experience with patterns of failure analysis. Neuro-Oncology 15 (suppl 3):iii179, 2013.
- Weksberg DC, Yang JN, Tam AL, McAleer MF, Li J, Ghia AJ, Wang XA, McRae SE, Settle SH, Rhines LD, Chang EL, and Brown PD. A prospective study using implanted fiducial markers to assess treatment accuracy in spinal stereotactic body radiation therapy. American Radium Society 95th Annual Meeting, Scottsdale, AZ, 2013.
- Ghia AJ, Mahajan A, Allen PK, Armstrong TS, Lang FF, Gilbert MR, Brown PD. Supratentorial gross-totally resected non-anaplastic ependymoma: population based patterns of care and outcomes analysis. American College of Radiation Oncology Annual Meeting, San Antonio, TX, 2013.
- Beck RE, Gaffney DK, Ghia AJ, Poppe MM. Survival Benefit for Surgery following Radiotherapy for Early Stage Cervical Adenocarcinoma: Data from the Surveillance, Epidemiology and End Results (SEER) Program. American Radium Society 94th Annual Meeting, Las Vegas, NV, 2012.
- Ghia AJ, Allen PK, Mahajan A, Penas-Prado M, McCutcheon IE, Brown PD. Intracranial hemangiopericytoma and the role of radiation therapy: a population based analysis. 14th Annual Brain Tumor Update and 3rd Annual International Symposium on Long-Term Control of Metastases to the Brain, Las Vegas, NV, 2012, 2012.
- Wagner A, Pappas L, Ghia A, Gaffney D. Impact of Tumor Size on Survival in Cancer of the Cervix. International Journal of Radiation Oncology Biology Physics 81(2 (Supp)):S459, 2011.
- Ghia AJ, Jensen RL, Shrieve AF, Shrieve DC. Analysis of factors which influence local control following SRS for brain metastases. 10th Biennial Congress and Exhibition of the International Stereotactic Radiosurgery Society, Paris, France, 2011.
- Ghia AJ, Fischbach AJ, Kringlen MW, Harker CP, Watson GA. Yttrium-90 Microspheres (Therasphere) in the Treatment of Primary and Metastatic Liver Tumors: A Retrospective Analysis. International Journal of Radiation Oncology Biology Physics 78(3 (Supp)):S322, 2010.
- Ghia AJ, Shrieve DC, Tward JD. Adjuvant Radiotherapy Use and Patterns of Care Analysis for Margin Positive Prostate Adenocarcinoma with Extracapsular Extension. International Journal of Radiation Oncology Biology Physics 75(3 (Supp)):S309, 2009.
- Gondi V, Tome WA, Marsh J, Struck A, Ghia A, Turian JV, Bentzen SM, Kuo JS, Khuntia D, Mehta MP. Estimated Risk of Perihippocampal Disease Progression after Hippocampal Avoidance during Whole-brain Radiotherapy: Comprehensive Multi-institution Review of 371 Patients with 1133 Brain Metastases. International Journal of Radiation Oncology Biology Physics 75(3 (Supp)):S236, 2009.
- Ghia AJ, Harari PM, Jaradat HA, Connor NP, Tome WA. Normal tissue avoidance and target coverage for oropharynx cancer: radiation technique and patient perceptions regarding quality of life. Multidisciplinary Head and Neck Cancer Symposium, Palm Springs, CA, 2007.
- Ghia AJ, Tome W, Thomas S, Cannon G, Mehta M, Kuo J. Distribution of brain metastases in relation to the hippocampus. AANS/CNS Section on Tumors Seventh Biennial Satellite Symposium, Washington D.C, 2007.
- Ghia AJ, Tome W, Thomas S, Cannon G, Mehta M, Kuo J. Distribution of brain metastases in relation to the hippocampus. American Association of Neurological Surgeons Annual Meeting, Washington D.C, 2007.
- Wheeler DL, Ghia AJ, et. al.. Role of Src family kinases in acquired resistance to cetuximab. AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, San Francisco, CA, 2007.
- Ghia AJ, Theodore W. Imaging 5-HT1A Receptors in Epilepsy: [18F]FCWAY PET and Volumetric MRI. Summer Research Fellowship Poster Day, NINDS, NIH, Bethesda, MD, 2001.
Book Chapters
- Bernard V, Ghia AJ. Management of spine SBRT adverse effects. In: Intracranial and Spinal Radiosurgery. Springer, 2021.
- Elhammali A, Ghia AJ. Radiation Emergencies, Benign Disease and Palliation. In: Pocket Radiation Oncology – The MD Anderson Manual of Radiation Oncology. 1. Lippincott Williams & Wilkins, 2019.
- Ghia AJ. Fractionated Radiotherapy of Intracranial Gliomas. In: Prog Neurol Surg. Basel, Karger, 38-47, 2018.
- Ghia AJ, Prayongrat A. Vertebral Body Metastases. In: Adult CNS Radiation Oncology: Principles and Practice. Springer, 2018.
- Bernard, V, Ghia AJ. Hemangiopericytoma. In: Adult CNS Radiation Oncology: Principles and Practice. Springer, 2018.
- Komaki R, Ghia AJ. Brain Metastases from Lung Cancer. In: Lung Cancer. 4th. Wiley-Blackwell: Oxford, 2014.
- Ghia AJ, Komaki R. Brain Metastases from Lung Cancer. In: Primary Tumor to Brain Metastasis: Tumor to Tumor. Springer Science and Business Media, 2014.
- Ghia AJ, Choi S. Role of Traditional and Stereotactic Radiation in RCC. In: Renal Cell Carcinoma. Oxford University Press, 2014.
- Ghia AJ, Gaffney DK. Radiotherapy for vulvar and vaginal cancer. In: Textbook of Gynaecological Oncology. 2nd. Gunes Publishing: Ankara, 2011.
- Ghia AJ, Proctor M. Pediatric Spinal Infection. In: Principles and Practice of Pediatric Neurosurgery. Thieme Medical Publishers: New York, 2007.
Grant & Contract Support
Title: | Prophylactic cement augmentation for patients at high risk for developing vertebral body compression fracture following spine stereotactic radiosurgery: a randomized Phase II clinical trial |
Funding Source: | Gateway For Cancer Research |
Role: | Principal Investigator |
Title: | Single versus multifraction salvage spine stereotactic radiosurgery for previously irradiated spinal metastases: a randomized Phase II clinical trial |
Funding Source: | MDACC - Clinical Innovator Award |
Role: | Principal Investigator |