Anastasios Maniakas, M.D., Ph.D., FRCSC
Department of Head and Neck Surgery, Division of Surgery
About Dr. Anastasios Maniakas
Anastasios Maniakas, M.D., PhD., is an Assistant Professor in the Department of Head and Neck Surgery at The University of Texas MD Anderson Cancer Center. Dr. Maniakas received his undergraduate, master’s, and doctoral degrees from McGill University, and his medical doctorate from the University of Montreal. He completed his residency at the University of Montreal followed by a fellowship in head and neck surgical oncology at The University of Texas MD Anderson Cancer Center. His clinical expertise is in head and neck cancers, with an emphasis on thyroid and parathyroid disease, oral cavity cancer, skin cancers, and salivary gland neoplasms. Dr. Maniakas’ research interests focus on translational research, with the goal to identify and develop novel head and neck cancer treatments and lead pre-clinical and multi-phase clinical trials, while also co-leading clinical trials evaluating minimally invasive treatments for advanced and/or recurrent head and neck cancers. Furthermore, Dr. Maniakas is investigating the effect of the microbiome in the development, progression, and recurrence of cancer in his patient population.
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Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2022 | McGill University, Montreal, CAN, PHD, Experimental Surgery |
| 2018 | McGill University, Montreal, CAN, MSc, Experimental Surgery |
| 2013 | University of Montreal, Montreal, CAN, MD, Medical Doctorate |
| 2009 | McGill University, Montreal, CAN, BSc, Microbiology & Immunology, Minor in Classical Studies |
Postgraduate Training
| 2019-2020 | Research Fellowship, Head and Neck Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX |
| 2018-2019 | Clinical Fellowship, Head and Neck Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX |
| 2014-2015 | Global Clinical Scholars Research Training Program, Harvard Medical School, Boston, MA |
| 2013-2018 | Clinical Residency, Otolaryngology - Head & Neck Surgery, University of Montreal, Montreal |
Board Certifications
| 2020 | Royal College of Physicians and Surgeons of Canada |
Experience & Service
Academic Appointments
Assistant Professor, Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Montreal - Hopital Maisonneuve-Rosemont, Montreal, 2020 - 2021
Honors & Awards
| 2024 | Top 1% of providers nationally ranked for Fiscal Year 2024, Clinician and Group Consumer Assessment of Healthcare Providers and Systems (CGCAHPS) |
| 2024 | Perfect Score Provider for Fiscal Year 2024, Clinician and Group Consumer Assessment of Healthcare Providers and Systems (CGCAHPS) |
| 2024 | ENT Research All-Star Top 5%, Avant-Garde Health |
| 2019 | CIHR Vanier CGS Doctoral Award, Canadian Institutes of Health Research |
| 2018 | Daniel-Tasse Award Department of Surgery, University of Montreal |
| 2018 | Junior Fellowship Award, European Rhinologic Society |
| 2017 | Detweiler Fellowship Award, Royal College of Canada |
| 2015 | Harvard Medical School - Distinction, Harvard Medical School |
| 2015 | Frederick Banting and Charles Best CGS-M, Canadian Institutes of Health Research |
| 2015 | Master's Degree Award, FRQS |
| 2009 | McGill University Academy of Athens Prize, McGill University |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Multidisciplinary Oropharyngeal Cancer Extra-Nodal Extension (OPC ENE) Assessment Working Group, Sahin O, Kamel S, Wahid KA, Dede C, Taku N, He R, Naser MA, Sharafi S, Mäkitie A, Kann BH, Kaski K, Sahlsten J, Jaskari J, Amit M, Chronowski GM, Diaz EM, Garden AS, Goepfert RP, Guenette JP, Gunn GB, Hirvonen J, Hoebers F, Hutcheson KA, Guha-Thakurta N, Johnson J, Kaya D, Khanpara SD, Nyman K, Lai SY, Lango M, Learned KO, Lee A, Lewis CM, Maniakas A, Moreno AC, Myers JN, Phan J, Pytynia KB, Rosenthal DI, Sandulache VC, Schellingerhout D, Shah SJ, Sikora AG, Mohamed ASR, Chen MM, Fuller CD. Multi-Specialty Expert Physician Identification of Extranodal Extension in Computed Tomography Scans of Oropharyngeal Cancer Patients: Prospective Blinded Human Inter-Observer Performance Evaluation. medRxiv, 2024. e-Pub 2024. PMID: 36865096.
- Awad A, Pal K, Maniakas A, Zafereo M, Grosu H, Cabanillas M, Chen SR. Carotid blowout into the trachea: unusual entity with unexpected management outcome. J Neurointerv Surg 16(7):743-746, 2024. e-Pub 2024. PMID: 37532452.
- Dayan GS, Bahig H, Johnson-Obaseki S, Eskander A, Hong X, Chandarana S, de Almeida JR, Nichols AC, Hier M, Belzile M, Gaudet M, Dort J, Matthews TW, Hart R, Goldstein DP, Yao CMKL, Hosni A, MacNeil D, Fowler J, Higgins K, Khalil C, Khoury M, Mlynarek AM, Morand G, Sultanem K, Maniakas A, Ayad T, Christopoulos A. Oncologic Significance of Therapeutic Delays in Patients With Oral Cavity Cancer. JAMA Otolaryngol Head Neck Surg 149(11):961-969, 2023. e-Pub 2023. PMID: 37422839.
- Renteria AE, Valera FCP, Maniakas A, Adam D, Filali-Mouhim A, Ruffin M, Mfuna LE, Brochiero E, Desrosiers MY. Azithromycin Mechanisms of Action in CRS Include Epithelial Barrier Restoration and Type 1 Inflammation Reduction. Otolaryngol Head Neck Surg 169(4):1055-1063, 2023. e-Pub 2023. PMID: 37125631.
- Morand GB, Eskander A, Fu R, de Almeida J, Goldstein D, Noroozi H, Hosni A, Seikaly H, Tabet P, Pyne JM, Matthews TW, Dort J, Nakoneshny S, Christopoulos A, Bahig H, Johnson-Obaseki S, Hua N, Gaudet M, Jooya A, Nichols A, Laxague F, Cecchini M, Du J, Shapiro J, Karam I, Dziegielewski PT, Hanubal K, Erovic B, Grasl S, Davies J, Monteiro E, Gete M, Witterick I, Sadeghi N, Richardson K, Shenouda G, Maniakas A, Landry V, Gupta M, Zhou K, Mlynarek AM, Pusztaszeri M, Sultanem K, Hier MP. The protective role of postoperative radiation therapy in low and intermediate grade major salivary gland malignancies: A study of the Canadian Head and Neck Collaborative Research Initiative. Cancer 129(20):3263-3274, 2023. e-Pub 2023. PMID: 37401841.
- Hamidi S, Maniakas A. Recent advances in anaplastic thyroid cancer management. Curr Opin Endocrinol Diabetes Obes 30(5):259-264, 2023. e-Pub 2023. PMID: 37410453.
- Tasoulas J, Srivastava S, Xu X, Tarasova V, Maniakas A, Karreth FA, Amelio AL. Genetically engineered mouse models of head and neck cancers. Oncogene 42(35):2593-2609. e-Pub 2023. PMID: 37474617.
- Chen YH, Cabanillas M, Sperling J, Xu L, Goswami M, Maniakas A, Williams MD, Lai SY, Busaidy N, Dadu R, Zafereo M, Wang J. Prior thyroid and non-thyroid cancer history do not significantly alter overall survival in patients diagnosed with anaplastic thyroid carcinoma. Thyroid 33(3):321-329, 2023. e-Pub 2023. PMID: 36511380.
- Jared A Shenson, Mark E Zafereo, Mark Lee, Kevin J Contrera, Lei Feng, Mongkol Boonsripitayanon, Neil Gross, Ryan Goepfert, Maniakas A, Jennifer Rui Wang, Libby Grubbs, Ara Vaporciyan, Wayne Hofstetter, Stephen Swisher, Reza Mehran, David Rice, Boris Sepesi, Mara Antonoff, Maria Cabanillas, Naifa Busaidy, Ramona Dadu, Natalie L Silver. Clinical outcomes of combined cervical and transthoracic surgical approaches in patients with advanced thyroid cancer. Head & Neck 45(3):547-554, 2023. e-Pub 2023. PMID: 36524701.
- Zhao X, Wang JR, Dadu R, Busaidy NL, Xu L, Learned KO, Chasen NN, Vu T, Maniakas A, Eguia AA, Diersing J, Gross ND, Goepfert R, Lai SY, Hofmann MC, Ferrarotto R, Lu C, Gunn GB, Spiotto MT, Subbiah V, Williams MD, Cabanillas ME, Zafereo ME. Surgery After BRAF-Directed Therapy Is Associated with Improved Survival in BRAFV600E Mutant Anaplastic Thyroid Cancer: A Single-Center Retrospective Cohort Study. Thyroid. e-Pub 2023. PMID: 36762947.
- Contrera K, Gule-Monroe M, Hu M, Cabanillas M, Busaidy M, Dadu R, Waguespack S, Wang J, Maniakas A, Lai SY, Diersing J, Kwon M, Grubbs E, Subbiah V, Zafereo M. Neoadjuvant Selective RET Inhibitor for Medullary Thyroid Cancer: A Case Series. Thyroid 33(1):129-132, 2023. e-Pub 2023. PMID: 36503246.
- Lampasona G, Berdugo J, Noujaim J, Gologan O, Maniakas A.. Locoregionally Advanced, BRAF V600L-Positive, Mucosal Melanoma of the Hypopharynx Treated With a Combination of BRAF and MEK Inhibitors. Journal of Clinical Oncology - Precision Oncology, 2022. PMID: 35709404.
- Maniakas A, Zafereo M, Cabanillas ME.. Anaplastic Thyroid Cancer: New Horizons and Challenges. Updates in Thyroidology - Endocrinology and Metabolism Clinics of North America 51(2):391-401, 2022. PMID: 35662448.
- Zagury-Orly I, Khaouam N, Noujaim J, Desrosiers MY, Maniakas A. The Effect of Radiation and Chemoradiation Therapy on the Head and Neck Mucosal Microbiome: A Review. Front Oncol 11:5068, 2021. e-Pub 2021. PMID: 34926301.
- Maniakas A, Henderson YC, Hei H, Peng S, Chen Y, Jiang Y, Ji S, Cardenas M, Chiu Y, Bell D, Williams MD, Hofmann MC, Scherer SE, Wheeler DA, Busaidy NL, Dadu R, Wang JR, Cabanillas ME, Zafereo M, Johnson FM, Lai SY. Novel Anaplastic Thyroid Cancer PDXs and Cell Lines: Expanding Preclinical Models of Genetic Diversity. J Clin Endocrinol Metab 106(11):e4652-e4665, 2021. PMID: 34147031.
- Henderson YC, Mohamed ASR, Maniakas A, Chen Y, Powell RT, Peng S, Cardenas M, Williams MD, Bell D, Zafereo ME, Wang RJ, Scherer SE, Wheeler DA, Cabanillas ME, Hofmann MC, Johnson FM, Stephan CC, Sandulache V, Lai SY. A High-throughput Approach to Identify Effective Systemic Agents for the Treatment of Anaplastic Thyroid Carcinoma. J Clin Endocrinol Metab 106(10):2962-2978, 2021. PMID: 34120183.
- Chen Y, Maniakas A, Tan L, Cui M, Le X, Niedzielski JS, Michel KA, Harlan CJ, Lu W, Henderson YC, Mohamed ASR, Lorenzi PL, Putluri N, Bankson JA, Sandulache VC, Lai SY. Development of a rational strategy for integration of lactate dehydrogenase A suppression into therapeutic algorithms for head and neck cancer. Br J Cancer 124(10):1670-1679, 2021. e-Pub 2021. PMID: 33742144.
- Maniakas A, Asmar MH, Renteria AE, Nayan S, Alromaih S, Endam LM, Sampalis JS, Desrosiers M. Azithromycin in high-risk, refractory chronic rhinosinusitus after endoscopic sinus surgery and corticosteroid irrigations: a double-blind, randomized, placebo-controlled trial. Int Forum Allergy Rhinol 11(4):747-754, 2021. e-Pub 2020. PMID: 32929891.
- Renteria AE, Maniakas A, Mfuna LE, Asmar MH, Gonzalez E, Desrosiers M. Low-dose and long-term azithromycin significantly decreases Staphylococcus aureus in the microbiome of refractory CRS patients. Int Forum Allergy Rhinol 11(2):93-105, 2021. e-Pub 2020. PMID: 32713109.
- Srivastava A, Maniakas A, Myers J, Chambers MS, Cardoso R. Reconstruction of intraoral oncologic surgical defects with Integra® bilayer wound matrix. Clin Case Rep 9(1):213-219, 2021. e-Pub 2020. PMID: 33489162.
- Renteria AE, Mfuna Endam L, Adam D, Filali-Mouhim A, Maniakas A, Rousseau S, Brochiero E, Gallo S, Desrosiers M. Azithromycin Downregulates Gene Expression of IL-1β and Pathways Involving TMPRSS2 and TMPRSS11D Required by SARS-CoV-2. Am J Respir Cell Mol Biol 63(5):707-709, 2020. PMID: 32857620.
- Maniakas A, Dadu R, Busaidy NL, Wang JR, Ferrarotto R, Lu C, Williams MD, Gunn GB, Hofmann MC, Cote G, Sperling J, Gross ND, Sturgis EM, Goepfert RP, Lai SY, Cabanillas ME, Zafereo M. Evaluation of Overall Survival in Patients With Anaplastic Thyroid Carcinoma, 2000-2019. JAMA Oncol 6(9):1397-1404, 2020. PMID: 32761153.
- Maniakas A, Jozaghi Y, Zafereo ME, Sturgis EM, Su SY, Gillenwater AM, Gidley PW, Lewis CM, Diaz E, Goepfert RP, Kupferman ME, Gross ND, Hessel AC, Pytynia KB, Nader ME, Wang JR, Lango MN, Kiong KL, Guo T, Zhao X, Yao CMKL, Appelbaum E, Alpard J, Garcia JA, Terry S, Flynn JE, Bauer S, Fournier D, Burgess CG, Wideman C, Johnston M, You C, De Luna R, Joseph L, Diersing J, Prescott K, Heiberger K, Mugartegui L, Rodriguez J, Zendehdel S, Sellers J, Friddell RA, Thomas A, Khanjae SJ, Schwarzlose KB, Chambers MS, Hofstede TM, Cardoso RC, Wesson RA, Won A, Otun AO, Gombos DS, Al-Zubidi N, Hutcheson KA, Gunn GB, Rosenthal DI, Gillison ML, Ferrarotto R, Weber RS, Hanna EY, Myers JN, Lai SY. Head and neck surgical oncology in the time of a pandemic: Subsite-specific triage guidelines during the COVID-19 pandemic. Head Neck 42(6):1194-1201, 2020. PMID: 32342541.
- Zahedi A, Bondaz L, Rajaraman M, Leslie WD, Jefford C, Young JE, Pathak KA, Bureau Y, Rachinsky I, Badreddine M, De Brabandere S, Fong H, Maniakas A, Van Uum S. Risk for Thyroid Cancer Recurrence Is Higher in Men Than in Women Independent of Disease Stage at Presentation. Thyroid 30(6):871-877, 2020. e-Pub 2019. PMID: 31524071.
- Yang N, Beaudoin PL, Nguyen M, Maillé H, Maniakas A, Saliba I. Subannular ventilation tubes in the pediatric population: Clinical outcomes of over 1000 insertions. Int J Pediatr Otorhinolaryngol 131:109859, 2020. e-Pub 2020. PMID: 31918244.
- Voizard B, Maniakas A, Saliba I. Office-Based Stapes Surgery. Otolaryngol Head Neck Surg 161(6):1018-1026, 2019. e-Pub 2019. PMID: 31570044.
- Yang N, Boudoux C, De Montigny E, Maniakas A, Gologan O, Madore WJ, Khullar S, Guertin L, Christopoulos A, Bissada E, Ayad T. Rapid head and neck tissue identification in thyroid and parathyroid surgery using optical coherence tomography. Head Neck 41(12):4171-4180, 2019. e-Pub 2019. PMID: 31571306.
- Asmar MH, Gaudreau A, Maniakas A, Mfuna Endam L, Desrosiers M. An Evaluation of SPARC Protein as a Serum Biomarker of Chronic Rhinosinusitis. Otolaryngol Head Neck Surg 160(1):158-164, 2019. e-Pub 2018. PMID: 30274534.
- Maniakas A, Davies L, Zafereo ME. Thyroid Disease Around the World. Otolaryngol Clin North Am 51(3):631-642, 2018. e-Pub 2018. PMID: 29548512.
- Maniakas A, Desrosiers M, Asmar MH, Al Falasi M, Endam LM, Hopkins C, Philpott C, Erskine S, Smith R, Kilty S. Eustachian tube symptoms are frequent in chronic rhinosinusitis and respond well to endoscopic sinus surgery. Rhinology 56(2):118-121, 2018. PMID: 29509831.
- Maniakas A, Asmar MH, Renteria Flores AE, Nayan S, Alromaih S, Mfuna Endam L, Desrosiers MY. Staphylococcus aureus on Sinus Culture Is Associated With Recurrence of Chronic Rhinosinusitis After Endoscopic Sinus Surgery. Front Cell Infect Microbiol 8:150, 2018. e-Pub 2018. PMID: 29868506.
- Moderie C,Maniakas A, Moumdjian R, Alhabib SF, Saliba I. Eustachian Tube Obliteration and its Effect on Rhinoliquorrhea in Translabyrinthine Vestibular Schwannoma Excision. J Int Adv Otol 13(2):191-194, 2017. PMID: 28816691.
- Maniakas A, Christopoulos A, Bissada E, Guertin L, Olivier MJ, Malaise J, Ayad T. Perioperative practices in thyroid surgery: An international survey. Head Neck 39(7):1296-1305, 2017. e-Pub 2017. PMID: 28493562.
- Gosselin É,Maniakas A, Saliba I. Meta-analysis on the clinical outcomes in patients with intralabyrinthine schwannomas: conservative management vs. microsurgery. Eur Arch Otorhinolaryngol 273(6):1357-67, 2016. e-Pub 2015. PMID: 25673023.
- Maniakas A, Nehme J, Dufour JJ, Saliba I. Delaying partial stapedectomy for otosclerosis: effects on long-term hearing outcomes following surgery. Eur Arch Otorhinolaryngol 272(7):1605-11, 2015. e-Pub 2014. PMID: 24609646.
- Benamira LZ, Maniakas A, Alzahrani M, Saliba I. Common features in patients with superior canal dehiscence declining surgical treatment. J Clin Med Res 7(5):308-14, 2015. e-Pub 2015. PMID: 25780478.
- Saliba I, Maniakas A, Benamira LZ, Nehme J, Benoit M, Montreuil-Jacques V. Superior canal dehiscence syndrome: clinical manifestations and radiologic correlations. Eur Arch Otorhinolaryngol 271(11):2905-14, 2014. e-Pub 2013. PMID: 24162764.
- Maniakas A, Moubayed SP, Ayad T, Guertin L, Nguyen-Tan PF, Gologan O, Soulieres D, Christopoulos A. North-American survey on HPV-DNA and p16 testing for head and neck squamous cell carcinoma. Oral Oncol 50(10):942-6, 2014. e-Pub 2014. PMID: 25096827.
- Maniakas A, Saliba I. Neurofibromatosis type 2 vestibular schwannoma treatment: a review of the literature, trends, and outcomes. Otol Neurotol 35(5):889-94, 2014. PMID: 24675066.
- Saliba J, Payne RJ, Varshney R, Sela E, Maniakas A, Rahme E, Mlynarek A, Caglar D, Hier MP, Tamilia M. Sentinel Lymph Node Biopsy Status Correlates with Postoperative Stimulated Thyroglobulin Levels in Low-risk Papillary Thyroid Cancer Patients. Endocr Pract 20(5):399-404, 2014. PMID: 24325994.
- Maniakas A, Forest VI, Jozaghi Y, Saliba J, Hier MP, Mlynarek A, Tamilia M, Payne RJ. Tumor classification in well-differentiated thyroid carcinoma and sentinel lymph node biopsy outcomes: a direct correlation. Thyroid 24(4):671-4, 2014. e-Pub 2014. PMID: 24199963.
- Maniakas A, Desrosiers M. Azithromycin add-on therapy in high-risk postendoscopic sinus surgery patients failing corticosteroid irrigations: A clinical practice audit. Am J Rhinol Allergy 28(2):151-5, 2014. e-Pub 2013. PMID: 24598145.
- Maniakas A, Saliba I. Microsurgery versus stereotactic radiation for small vestibular schwannomas: a meta-analysis of patients with more than 5 years' follow-up. Otol Neurotol 33(9):1611-20, 2012. PMID: 22996165.
- Maniakas A, Saliba I. Conservative management versus stereotactic radiation for vestibular schwannomas: a meta-analysis of patients with more than 5 years' follow-up. Otol Neurotol 33(2):230-8, 2012. PMID: 22222572.
Book Chapters
- Maniakas A, Zafereo M, Cabanillas ME,. Anaplastic Thyroid Cancer: new Horizons and Challenges. In: Updates in Thyroidology. Elsevier, 2022.
- Maniakas A, Chen A, Chiang FY, Zafereo M.. Lateral neck dissection: Indications and technique. In: Randolph: Surgery of the Thyroid and Parathyroid Glands. 3. Elsevier, 2020.
- Wiseman K, Maniakas A. Legal, Ethical & Socioeconomic Issues in Plastic Surgery. In: Facial plastic and reconstructive surgery - High-yield board review. 1. JP Medical Inc, 2019.
- Voizard B,Maniakas A. Otoplasty. In: Facial plastic and reconstructive surgery - High-yield board review. 1. JP Medical Inc, 2019.
- Maniakas A, Davies L, Zafereo M.. Thyroid Disease around the world. In: Global Health in Otolaryngology: Otolaryngologic Clinics of North America. Elsevier, 2018.
- Maniakas A, Christopoulos A. Cancer of the cervical esophagus. In: Eugene Myers Operative Otolaryngology - Head and Neck Surgery. 3. Elsevier, 2017.
Grant & Contract Support
| Date: | 2024 - Present |
| Title: | Pan-RAF inhibitor in advanced thyroid cancer PDX models |
| Funding Source: | Jazz Pharmaceuticals |
| Role: | Principal Investigator |
| Date: | 2024 - Present |
| Title: | SGK1 Inhibitor in advanced thyroid cancer PDX models |
| Funding Source: | Thryv Therapeutics Inc |
| Role: | Co-Principal Investigator |
| Date: | 2019 - 2020 |
| Title: | PDX model development in aggressive thyroid cancers |
| Funding Source: | Fonds de Recherche du Quebec - Sante |
| Role: | Co-Principal Investigator |
| Date: | 2014 - 2017 |
| Title: | Investigator-Initiated Research Grant - Drug Repurposing in Otolaryngologic diseases |
| Funding Source: | Pfizer |
| Role: | Co-Principal Investigator |
Patient Reviews
CV information above last modified December 16, 2024