About Dr. Andrew J Shepherd
Dr. Shepherd is interested in understanding the impact of neuroimmune interactions in chronic pain states. It has been shown that macrophages can profoundly affect the progression of nerve injury and the associated pain. These processes can be influenced by pre-existing systemic inflammation, such as that seen in obesity and certain types of cancer.
Dr. Shepherd engages in pre-clinical research to elucidate the mechanisms that link inflammation to pain induced by various forms of injury, including joint damage and chemotherapy-induced neuropathy, with a particular focus on signaling related to the renin-angiotensin system. The ultimate goal of this research is to identify interventions that can mitigate or prevent the development of pain associated with these chronic disease states.
Present Title & Affiliation
Assistant Professor, Department of Symptom Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
|2006||The University of Manchester, Manchester, GBR, PHD, Neuroimmunomodulation|
|2003||The University of Manchester Institute of Science & Technology, Manchester, GBR, BS, Molecular Cell Biology|
Experience & Service
Adjuct Lecturer, Saint Louis University, St. Louis, MO, 2017 - 2017
Instructor, Washington University, St. Louis, MO, 2015 - 2018
Assistant Research Scientist, University of Iowa, Iowa City, IA, 2014 - 2014
Course Coordinator, University of Iowa, Iowa City, IA, 2013 - 2014
Lecturer, University of Iowa, Iowa City, IA, 2012 - 2013
Postdoctoral Fellow, University of Iowa, Iowa City, IA, 2008 - 2014
Postdoctoral Research Fellow, University of Manchester, Manchester, 2006 - 2007
Research Assistant, University of Manchester Institute of Science and Technology, Manchester, 2002 - 2003
- Warwick CA, Shutov LP, Shepherd AJ, Mohapatra DP, Usachev YM. Mechanisms underlying mechanical sensitization induced by complement C5a: the roles of macrophages, TRP channels and CGRP receptors. Pain 160(3):702-711, 2019. e-Pub 2018. PMID: 30507785.
- Shepherd AJ, Mohapatra DP. Attenuation of un-evoked mechanical and cold pain hypersensitivity associated with experimental neuropathy in mice by angiotensin II type-2 receptor antagonism. Anesth Analg. e-Pub 2018. PMID: 30320646.
- Shepherd AJ, Mickle AD, Golden JP, Mack MR, Halabi CM, de Kloet AD, Samineni VK, Kim BS, Krause EG, Gereau RW, Mohapatra DP. Macrophage Angiotensin II type-2 Receptor Triggers Neuropathic Pain. Proc Natl Acad Sci U S A 115(34):E8057-E8066, 2018. e-Pub 2018. PMID: 30082378.
- Shepherd AJ, Copits BA, Mickle AD, Kadunganattil S, Tadinada SM, de Kloet AD, Samineni VK, Valtcheva MV, McIlvried LA, Sheahan TD, Jain S, Ray PR, Usachev YM, Dussor G, Krause EG, Price TJ, Gereau RW, Mohapatra DP. Angiotensin II triggers painful macrophage-to-sensory neuron redox crosstalk. J Neuroscience 38(32):7032-7057, 2018.
- Shepherd AJ, Mickle AD, McIlvried LA, Gereau RW, Mohapatra DP. Parathyroid hormone-related peptide activates and modulates TRPV1 channel in human DRG neurons. European Journal of Pain 22(9):1685-1690, 2018. PMID: 29797679.
- Shepherd AJ, Mohapatra DP. Pharmacological validation of voluntary gait and mechanical sensitivity assays associated with inflammatory and neuropathic pain in mice. Neuropharmacology 130:18-29, 2018. e-Pub 2017. PMID: 29191755.
- Shepherd AJ, Cloud ME, Cao YQ, Mohapatra DP. Deficits in burrowing behaviors are indicative of neuropathic but not inflammatory pain or migraine in mice. Front Behav Neurosci 12:124, 2018. e-Pub 2018. PMID: 30002622.
- Shepherd AJ, Mickle AD, Kadunganattil S, Hu H, Mohapatra DP. Parathyroid hormone-related peptide elicits peripheral TRPV1-dependent mechanical hypersensitivity. Front Cell Neurosci 12:38, 2018. e-Pub 2018. PMID: 29497363.