Andrew G Sikora, MD, PhD
Department of Head and Neck Surgery, Division of Surgery
About Dr. Andrew G Sikora
Dr. Andrew Sikora is a Professor of Head and Neck Surgery at MD Anderson Cancer Center in Houston, Texas. He also serves as Director of Research for Head and Neck Surgery. Dr. Sikora’s clinical expertise is in oropharyngeal (throat) cancer and human papillomavirus (HPV)-related head and neck cancer. His research is focused on tumor immunology, and cancer immunotherapy. Dr. Sikora serves as a member of the National Institute of Health (NIH) National Cancer Institute’s Head and Neck Cancer Core Committee, and Immuno-Oncology Translational Network (IOTN) Steering Committee.
Present Title & Affiliation
Primary Appointment
Deputy Division Head, Basic/Translational Research, Department of Division of Surgery, Division of Surgery, UT MD Anderson Cancer Center, Houston, TX
Professor, Department of Head and Neck Surgery and Immunology, UT MD Anderson Cancer Center, Houston, TX
Director of Research, Department of Head and Neck Surgery, UT MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2000 | Albert Einstein College of Medicine, Bronx, New York, US, Microbiology and Immunology, Ph.D |
| 2000 | Albert Einstein College of Medicine, Bronx, New York, US, MD |
| 1996 | Albert Einstein College of Medicine, Bronx, New York, US, Microbiology and Immunology, M.S |
| 1992 | Yale University, New Haven, Connecticut, US, Biology, BS |
Postgraduate Training
| 2007-2008 | Clinical Fellowship, Head and Neck Surgical Oncology, UT MD Anderson Cancer Center, Houston, Texas |
| 2005-2007 | Research Fellowship, Melanoma Medical Oncology and Head and Neck Surgery, UT MD Anderson Cancer Center, Houston, Texas |
| 2000-2001 | General Surgery Internship, New York University School of Medicine, New York City, New York |
| 2000-2005 | Clinical Residency, Otolaryngology, New York University School of Medicine, New York, New York |
Licenses & Certifications
| 2023 | Georgia Composite Medical Board |
| 2023 | Mississippi State Board of Medical Licensure |
| 2023 | Oklahoma State Board of Medical Licensure |
| 2021 | Florida Board of Medicine |
| 2007 | Texas Medical Board |
| 2006 | American Board of Otolaryngology |
Experience & Service
Faculty Academic Appointments
Associate Professor, Department of Otolaryngology and Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, 2014 - 2020
Assistant Professor, Department of Otolaryngology-Head and Neck Surgery, Immunology, Oncologic Sciences, Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, 2008 - 2014
Administrative Appointments/Responsibilities
Vice Chair for Research, Department of Otolaryngology, Baylor College of Medicine, Houston, TX, 2014 - 2020
Co-Director, Head and Neck Cancer Program, Baylor College of Medicine, Houston, TX, 2014 - 2020
Director, Steven Sacks Clinical Research Fellowship, Mount Sinai School of Medicine, New York, NY, 2011 - 2014
Co-Chair, Head and Neck Cancer Disease Focus Group, Mount Sinai School of Medicine, New York, NY, 2009 - 2014
Director of Translational Research, Department of Head and Neck Surgery, Icahn School of Medicine of Mount Sinai, New York, NY, 2008 - 2014
Other Professional Positions
Chief Scientific Officer/Founder, Ovodex, LCC, Houston, TX, 2018 - 2020
Attending Surgeon, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, 2015 - 2020
Attending Surgeon, Elmhurst Hospital, Queens, NY, 2011 - 2014
Assistant Attending Surgeon, Elmhurst Hospital, Queens, NY, 2009 - 2011
Intramural Institutional Committee Activities
Member, TRIUMPH (Translational Research in Multi-Disciplinary Program), The University of Texas MD Anderson Cancer Center, 2021 - Present
Member, MD/PhD Admissions Committee, Mount Sinai School of Medicine, 2012 - 2014
Ad-hoc Reviewer, Protocol Review and Monitoring Committee, Mount Sinai School of Medicine, 2011 - 2014
Member, Graduate School Curriculum Committee, Mount Sinai School of Medicine, 2009 - 2011
Member, Institutional Review Board (IRB), Mount Sinai School of Medicine, 2009 - 2011
Member, Uncompensated Care Committee, The University of Texas MD Anderson Cancer Center, 2005 - 2007
Member, Curriculum Committee, New York University, 2003 - 2005
Member, House Staff Council, New York University, 2002 - 2003
Honors & Awards
| 2022 | President’s Faculty Excellence award - Faculty Honoree, Research Excellence, UT MD Anderson Cancer Center |
| 2016 | Ovodex, Top-10 finalist, OneStart Americas international technology start-up competition |
| 2014 | American Academy of Otolaryngology-Head and Neck Surgery Honors Award, American Academy of Otolaryngology-Head and Neck Surgery |
| 2014 - 2020 | Carolyn Weiss-Law Translational Research Scholar, Baylor College of Medicine |
| 2009 | Damon Runyon-Rachleff Innovation Award |
| 2008 | Maxwell Byers Award for Best Clinical Paper, American Head and Neck Society 7th International Meeting |
| 2007 | Award for Keystone Symposium: The Potent New Anti-Tumor Immunotherapies, National Cancer Institute |
| 2004 | Second place award for research, Triological Society Eastern Section Meeting |
| 2003 | First place award for research, NY Head and Neck Society |
| 2000 | Distinguished Performance in Research, the Associated Medical Schools of New York Research Competition, Associated Medical Schools of New York |
| 2000 | Associate Fellow, New York Academy of Medicine |
| 1999 | Alpha Omega Alpha Society |
| 1999 | Broad Street Pump Award for service to community and public health, Physicians for Social Responsibility |
| 1997 | AMSA/National Health Service Corps Award for a Community Service Project |
| 1995 | CIBA-GEIGY Community Service Award |
Professional Memberships
Selected Presentations & Talks
Regional Presentations
- 2023. Improving Therapeutic Outcomes by Targeting the Immunosuppressive Microenvironment of Oral Cancer. Invited. Thomas Jefferson University Hospital William Keane Lecture. Philadelphia, PA, US.
- 2022. The Head and Neck Cancer Immune Microenvironment - Where Immunotherapy Fails or Prevails. Invited. Keynote Speaker, 38th Annual Bay Area Residents' Research Symposium (BARRS) in Otolaryngology – Head & Neck Surgery. Oakland, CA, US.
- 2020. Targeting the tumor immune micro-environment (TIME) of HPV-related cancers. Invited. University of Florida - Cancer Center Grand Rounds. Gainesville, FL, US.
- 2020. Modulating the TIME (Tumor Immune MicroEnvironment) to enhance efficacy. Invited. NRG Oncology Cooperative Group Biannual Meeting - Immunotherapy and Immune modulation workshop. Houston, TX, US.
- 2019. Modulating the TIME (Tumor Immune MicroEnvironment) to improve treatment efficacy. Invited. University of Colorado, Anschutz, Cancer Center Grand Rounds. Denver, CO, US.
- 2019. Thinking outside the mouse: Using the chicken egg chorioallantoic membrane (CAM) model for CAR T cell evaluation. Invited. New Horizons in Immunotherapy for Head and Neck Cancer 2019 (National CME course). Newburgh, OR, US.
- 2019. Keynote address: Translational research in HPV-related head and neck cancers. Invited. Henry Ford Health System Annual Head and Neck Cancer Symposium. Detroit, MI, US.
- 2018. Targeting the Tumor Microenvironment to Enhance Efficacy of Chemo- and Immuno-Radiotherapy. Invited. New Horizons in Immunotherapy for Head and Neck Cancer 2018 (National CME course). Pittsburgh, PA, US.
- 2018. Combination immuno-radiotherapy for solid tumors: building the perfect beast. Invited. Grand Rounds. Sioux Falls, SD, US.
- 2017. Putting more zip in your zap: harnessing the immune system to make chemoradiotherapy great again!. Invited. Sioux Falls, SD, US.
- 2017. Making chemoradiotherapy great again by targeting the tumor immune microenvironment. Invited. University of Cincinnati Hematology-Oncology Grand Rounds. Cincinnati, OH, US.
- 2016. Targeting inflammation to reverse the immunosuppressive tumor microenvironment. Invited. New Horizons in Immunotherapy for Head and Neck Cancer. La Jolla, CA, US.
- 2016. Integrating immunotherapy with standard-of-care therapy for HPV-HIV co-infected head and neck cancer patients. Invited. Physicians Research Network. New York, NY, US.
- 2016. Optimizing the immune-stimulating effects of chemoradiotherapy: lessons from HPV-related head and neck cancer. Invited. Columbia University Medical College Hematology-Oncology Grand Rounds. New York, NY, US.
- 2016. Integration of immunotherapy with chemotherapy by targeting the tumor microenvironment. Invited. University of Maryland Department of Otolaryngology Grand Rounds. Baltimore, MD, US.
- 2015. Understanding and exploiting the immune effects of chemoradiation for HPV-related head and neck cancer. Invited. New Horizons in Immunotherapy for Head and Neck Cancer 2015 (National CME course). Newberg, OR, US.
- 2015. Integration of immunotherapy with chemoradiotherapy for HPV-related head and neck cancer: challenges and opportunities. Invited. Head and Neck Cancer Translational Subcommittee, NSABP-RTOG-GOG (NRG) Cooperative Group 2015 National Meeting. San Diego, CA, US.
- 2013. What can we learn from the immune responses of patients with HPV-related head and neck cancer?. Invited. Department of Surgery Research Conference. New York, NY, US.
- 2013. Understanding and exploiting the immune response to head and neck cancer. Invited. New York, NY, US.
- 2013. What can we learn from the effect of chemoradiation on the immune response to HPV-related cancer?. Invited. Dallas, TX, US.
- 2013. Immune-based therapy for head and neck cancers: building a better toolkit. Invited. Otolaryngology Grand Rounds. Bronx, NY, US.
- 2012. Starting your Surgeon-Scientist Career. Invited. National Leadership Initiative Conference. New York, NY, US.
- 2012. How epidemiology illuminates the biology of HPV-related head and neck cancer. Invited. Department of Otolaryngology Didactic Day Speaker. New Orleans, LA, US.
- 2011. INOS-directed targeted therapy: saying NO to tumor-mediated immunosuppression. Invited. UPMC Head and Neck Cancer SPORE Symposium. Pittsburgh, PA, US.
- 2011. How epidemiology illuminates the biology of HPV-related head and neck cancer. Invited. University of Pittsburgh Department of Otolaryngology Grand Rounds. Pittsburgh, PA, US.
- 2010. iNOS-directed targeted therapy for cutaneous melanoma. Invited. Department of Hematology and Oncology Grand Rounds. New York, NY, US.
- 2009. iNOS-directed targeted therapy for head and neck cancer. Invited. Head and Neck Cancer Program Fellow's Conference. New York, NY, US.
- 2009. iNOS-directed targeted therapy for head and neck tumors. Invited. Department of Otolaryngology Grand Rounds. New York, NY, US.
National Presentations
- 2024. The Tumor Immune Microenvironment in HPV Negative Patients. Invited. 2024 Multidisciplinary Head & Neck Cancers Symposium. Phoenix, AZ, US.
- 2023. Improving Therapeutic Outcomes by Targeting the Immunosuppressive Microenvironment of Oral Cancer. Invited. Thomas Jefferson University Hospital William Keane Lecture - Department of Otolaryngology – Head and Neck Surgery. Philadelphia, Pennsylvania, US.
- 2022. Evolving Role of Immunotherapy in the Management of Advanced/Recurrent Oral Cancer. Invited. 8th Meeting of the International Academy of Oral Oncology. Chicago, IL, US.
- 2022. The Head and Neck Cancer Immune Microenvironment - Where Immunotherapy Fails or Prevails. Invited. 38th Annual Bay Area Residents’ Research Symposium (BARRS) in Otolaryngology – Head & Neck Surgery. Oakland, California, US.
- 2011. Application of high resolution microendoscopy to real-time surgical margin detection and robotic surgery. Invited. International Society for Optics and Photonics (SPIE): Optical Imaging, Therapeutics, and Advanced Technology in Otolaryngology and Head and Neck Surgery. San Francisco, CA, US.
International Presentations
- 2023. Immunotherapy as Combined Modality Therapy. Invited. AHNS 11th International Conference on Head and Neck Cancer. Montreal, CA.
- 2019. It's a matter of TIME: Targeting the Tumor Immune Microenvironment to enhance immunotherapy efficacy. Invited. 2019 International Association for Dental Research General Session. British Columbia, CA.
- 2018. The chicken chorioallantoic membrane (CAM) as a platform for personalized medicine. Invited. Conference on Fourth Industrial Revolution and Healthcare. Colombo, LK.
- 2018. The chicken chorioallantoic membrane (CAM) as a platform for personalized medicine. Invited. Conference on Fourth Industrial Revolution and Healthcare. Colombo, LK.
- 2018. Targeting the adverse tumor immune microenvironment in head and neck cancer. Invited. International Association for Dental Research General Session. London, GB.
- 2017. TGF beta 1- reprogrammed MDSC lose immunosuppressive function and acquire Fas-dependent tumor killing activity. Invited. CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference. Mainz, DE.
- 2016. Harnessing the immune system for cancer therapy. Invited. Science, Technology, and Society (STS) Forum Sri Lanka, Sri Lanka Coordinating Secretariat for Science, Technology and Innovation (COSTI). Colombo, LK.
- 2013. Understanding the immune response during treatment of HPV+ head and neck cancer – Real Results from Real Patients. Invited. Sao Paolo, BR.
- 2010. Tumor-and host-expressed iNOS drive MDSC expansion and acquisition of suppressive activity. Invited. Latin American Association of Immunology, International Union against Cancer (IUCC): Immunotherapy 2010. Havana, CU.
- 2009. Interferon-alpha as an adjuvant for peptide vaccination. Invited. Cancer Vaccines/Adjuvants/ Delivery for the Next Decade (CVADD 2009). Dublin, IE.
Grant & Contract Support
| Date: | 2025 - 2028 |
| Title: | Synthetic lethality of TRIP13 and Aurora A in Rb-deficient cancer |
| Funding Source: | CPRIT |
| Role: | Co-I |
| ID: | RP250398 |
| Date: | 2024 - 2027 |
| Title: | Immune-Related Determinants of HPV-Associated Oropharyngeal Cancer Outcomes |
| Funding Source: | CPRIT |
| Role: | Co-I |
| ID: | RP230022 |
| Date: | 2023 - 2026 |
| Title: | Deep Learning Image Analysis Algorithms to Improve Oral Cancer Risk Assessment for Oral Potentially Malignant Disorders |
| Funding Source: | NIH/NIDCR |
| Role: | Co-I |
| ID: | R01DE030656 |
| Date: | 2022 - 2027 |
| Title: | Targeting head and neck cancer cells and the adverse tumor microenvironment with a novel small-molecule STAT3 inhibitor |
| Funding Source: | NIH/NCI |
| Role: | Multiple Principal Investigator |
| ID: | R01CA269516 |
| Date: | 2022 - 2027 |
| Title: | Functional roles of GOF TP53 mutations in metastasis and immunosuppression of head and neck cancers |
| Funding Source: | NIH/NIDCR |
| Role: | Multiple Principal Investigator |
| ID: | R01DE030875 |
| Date: | 2021 - 2026 |
| Title: | Targeting replication stress and homologous recombination repair mechanisms in HPV-positive and negative head and neck cancer |
| Funding Source: | NIH/NIDCR |
| Role: | Co-I |
| ID: | R01DE030104 |
| Date: | 2021 - 2026 |
| Title: | SynerGel: A Novel Tumor Microenvironment-Modulating Hydrogel for Local Immunotherapy |
| Funding Source: | NIH/NIDCR |
| Role: | Co-I |
| ID: | R01DE030140 |
Selected Publications
Peer-Reviewed Articles
- Villa JF, Ramirez MF, Anderson JL, Sikora AG, Sharma J, Cata JP. Perioperative Immunomodulation and Cancer Recurrence. Int Anesthesiol Clin 64(2):29-42, 2026. e-Pub 2026. PMID: 41525257.
- Silver NL, Dai J, Kerr TD, Altemus J, Garg R, Simmons H, Alban T, Noel-Romas L, Makarov V, Shih DJH, Kumar SV, Santos A, Akbani R, Burgener A, Dwidar M, Gross N, Sikora AG, Sayour EJ, Stacy A, Jobin C, Chan TA, Ferrarotto R, McGrail DJ. Intratumoral bacteria are immunosuppressive and promote immunotherapy resistance in head and neck squamous cell carcinoma. Nat Cancer 7(1):80-97, 2026. e-Pub 2026. PMID: 41482523.
- Shah, P, Mazumdar, T, Ghosh, S, Yapindi, L, Powell, RT, Park, YS, Shen, L, Fernandez, AM, Stephan, C, Wang, J, Sikora, AG, Kazi, J, Frederick, MJ, Johnson, FM. Polo-like kinase 1 inactivation enhances PI3K inhibition-mediated apoptosis of NOTCH1-mutant head and neck squamous cell carcinoma. Cancer Letters 625, 2025. e-Pub 2025. PMID: 40412794.
- Sahin O, Kamel S, Wahid KA, Dede C, Taku N, He R, Naser MA, Sharafi CS, Makitie A, Kann BH, Kaski K, Sahlsten J, Jaskari J, Amit M, Chronowski GM, Diaz EM Jr, Garden AS, Goepfert RP, Guenette JP, Gunn GB, Hirvonen J, Hoebers F, Hutcheson KA, Guha-Thakurta N, Johnson J, Kaya D, Khanpara SD, Nyman K, Lai SY, Lango M, Learned KO, Lee A, Lewis CM, Maniakas A, Moreno AC, Myers JN, Phan J, Pytynia KB, Rosenthal DI, Sandulache VC, Schellingerhout D, Shah SJ, Sikora AG, Mohamed ASR, Chen MM, Fuller CD. International multispecialty expert physician preoperative identification of extranodal extension in patients with oropharyngeal cancer using computed tomography: Prospective blinded human inter-observer performance evaluation. Cancer 131(7):e35815, 2025. e-Pub 2025. PMID: 40159431.
- Sun, P, Gu, KJ, Zheng, G, Sikora, AG, Li, C, Zafereo, M, Wei, P, Wu, J, Shete, S, Liu, J, Li, G. Genetic variations associated with telomere length predict the risk of recurrence of non-oropharyngeal head and neck squamous cell carcinoma. Molecular Carcinogenesis 63(9):1722-1737, 2024. e-Pub 2024. PMID: 38837510.
- Nipper, AJ, Warren, EA, Liao, KS, Liu, HC, Michikawa, C, Porter, CE, Wells, GA, Villanueva, M, Brasil da Costa, FH, Veeramachaneni, R, Villanueva, H, Suzuki, M, Sikora, AG. Chick Embryo Chorioallantoic Membrane as a Platform for Assessing the In Vivo Efficacy of Chimeric Antigen Receptor T-cell Therapy in Solid Tumors. ImmunoHorizons 8(8):598-605, 2024. e-Pub 2024. PMID: 39225630.
- Michikawa C, Gleber-Netto FO, Pickering CR, Rao X, Wang J, Sikora AG, Myers JN, Frederick MJ. Immune infiltration at the primary tumor is associated with clinical outcome of patients with extranodal extension of lymph node metastasis in oral cancer. Oral Oncol 153:106729, 2024. e-Pub 2024. PMID: 38663156.
- Niu Z, Sun P, Zafereo ME, Liu H, Wei P, Wu J, Gross ND, Shete S, Wei Q, Zheng G, Sikora AG, Calin GA, Li G. TGF-beta1 and TGF-betaR1 variants are associated with clinical outcomes in smoking-related head and neck cancer patients treated with chemoradiation through modulating microRNA-mediated regulation. Cancer Immunol Immunother 73(5):85, 2024. e-Pub 2024. PMID: 38554185.
- de Sousa, LG, Siqueira, JM, McGrail, DJ, Marques-Piubelli, ML, Neto, FL, Borgogno, SF, Nunes, FD, De Matos, LL, Kowalski, LP, Hoff, CO, Dai, H, Mitani, Y, Li, K, Williams, MD, Lin, S, El-Naggar, AK, Sikora, AG, Burks, JK, Gillison, M, Ferrarotto, R. The immunological milieu of oropharyngeal squamous cell carcinoma (OPC) according to HPV and smoking status and its influence on prognosis. Journal of Clinical Oncology 42(16), 2024. e-Pub 2024.
- Hoffman MR, Patro A, Huang LC, Chen SC, Berry LD, Gelbard A, Francis DO, Anderson C, Amin MR, Benninger MS, Blumin JH, Bock JM, Bryson PC, Castellanos PF, Clary MS, Cohen SM, Crawley BK, Dailey SH, Daniero JJ, Alarcon AD, Donovan DT, Edell ES, Ekbom DC, Fink DS, Franco RA, Garrett C, Guardiani EA, Hillel AT, Hoffman HT, Hogikyan ND, Howell RJ, Johns MM, Kasperbauer JL, Khosla SM, Kinnard C, Kupfer RA, Langerman AJ, Lentz RJ, Lorenz RR, Lott DG, Makani SS, Maldonado F, Mannion K, Matrka L, McWhorter AJ, Merati AL, Mori M, Netterville JL, O'Dell K, Ongkasuwan J, Postma GN, Reder LS, Rohde SL, Richardson BE, Rickman OB, Rosen CA, Rutter MJ, Sandhu GS, Schindler JS, Schneider G, Shah RN, Sikora AG, Sinard RJ, Smith ME, Smith LJ, Soliman AM, Sveinsdottir S, Van Daele DJ, Veivers D, Verma SP, Weinberger PM, Weissbrod PA, Wootten CT, Shyr Y. Impact of Serial Intralesional Steroid Injections on Idiopathic Subglottic Stenosis. Laryngoscope 133(9)::2255-2263, 2023. e-Pub 2023. PMID: 36286239.
- Sun P, Wei P, Liu H, Wu J, Gross ND, Sikora AG, Wei Q, Shete S, Zafereo ME, Liu J, Li G. GWAS-identified telomere length associated genetic variants predict risk of recurrence of HPV-positive oropharyngeal cancer after definitive radiotherapy. EBioMedicine 94:104722, 2023. e-Pub 2023. PMID: 37487414.
- Shi Y, Ren X, Cao S, Chen X, Yuan B, Brasil da Costa FH, Rodriguez Rosario AE, Corona A, Michikawa C, Veeramachaneni R, Osman AA, Xie T, Wang W, Sikora AG, Myers JN, Rangel R. TP53 gain-of-function mutation modulates the immunosuppressive microenvironment in non-HPV-associated oral squamous cell carcinoma. J Immunother Cancer 11(8), 2023. e-Pub 2023. PMID: 37604640.
- Dahlstrom KR, Sikora AG, Liu Y, Chang CC, Wei P, Sturgis EM, Li G. Characterization of the oral microbiota among middle-aged men with and without human papillomavirus infection. Oral Oncol 142:106401, 2023. e-Pub 2023. PMID: 37178654.
- Tierney WS, Huang LC, Chen SC, Berry LD, Anderson C, Amin MR, Benninger MS, Blumin JH, Bock JM, Bryson PC, Castellanos PF, Clary MS, Cohen SM, Crawley BK, Dailey SH, Daniero JJ, de Alarcon A, Donovan DT, Edell ES, Ekbom DC, Fink DS, Franco RA, Garrett CG, Guardiani EA, Hillel AT, Hoffman HT, Hogikyan ND, Howell RJ, Johns MM, Kasperbauer JL, Khosla SM, Kinnard C, Kupfer RA, Langerman AJ, Lentz RJ, Lorenz RR, Lott DG, Makani SS, Maldonado F, Matrka L, McWhorter AJ, Merati AL, Mori M, Netterville JL, O'Dell K, Ongkasuwan J, Postma GN, Reder LS, Rohde SL, Richardson BE, Rickman OB, Rosen CA, Rohlfing M, Rutter MJ, Sandhu GS, Schindler JS, Schneider GT, Shah RN, Sikora AG, Sinard RJ, Smith ME, Smith LJ, Soliman AMS, Sveinsdóttir S, Veivers D, Verma SP, Weinberger PM, Weissbrod PA, Wootten CT, Shyr Y, Francis DO, Gelbard A. Comparative Treatment Outcomes for Idiopathic Subglottic Stenosis: 5-Year Update. Otolaryngol Head Neck Surg 168(6):1570-1575, 2023. e-Pub 2023. PMID: 36939627.
- Yang C, Garg R, Fredenburg K, Weidert F, Mendez-Gomez H, Amdur R, Lee JH, Ku J, Kresak J, Staras S, Sikora AG, Wang L, McGrail D, Mitchell D, Sayour E, Silver N. Association of Suppressive Myeloid Cell Enrichment with Aggressive Oropharynx Squamous Cell Carcinoma. Cancers (Basel) 15(8), 2023. e-Pub 2023. PMID: 37190274.
- Guimares de Sousa, L, Neto, FL, Dal Lago, EA, Sikora, AG, Hanna, EY, Moreno, AC, Phan, J, Glisson, BS, Bell, D, Ferrarotto, R. Human papillomavirus status and prognosis of oropharyngeal high-grade neuroendocrine carcinoma. Oral Oncology 138, 2023. e-Pub 2023. PMID: 36702015.
- Xu, Y, Wang, Z, Wei, P, Gairola, R, Kelsey, KT, Sikora, AG, Li, G, Gu, J. Hypermethylation of nc886 in HPV-positive oropharyngeal cancer and its clinical implications. Molecular Therapy Nucleic Acids 30:596-605, 2022. e-Pub 2022. PMID: 36514351.
- Villanueva, H, Wells, GA, Miller, MT, Villanueva, M, Pathak, R, Castro, P, Ittmann, MM, Sikora, AG, Lerner, SP. Characterizing treatment resistance in muscle invasive bladder cancer using the chicken egg chorioallantoic membrane patient-derived xenograft model. Heliyon 8(12), 2022. e-Pub 2022. PMID: 36643309.
- Brenes DR, Nipper AJ, Tan MT, Gleber-Netto FO, Schwarz RA, Pickering CR, Williams MD, Vigneswaran N, Gillenwater AM, Sikora AG, Richards-Kortum RR. Mildly dysplastic oral lesions with optically-detectable abnormalities share genetic similarities with severely dysplastic lesions. Oral Oncol 135:106232. e-Pub 2022. PMID: 36335817.
- Koyuncu CF, Nag R, Lu C, Corredor G, Viswanathan VS, Sandulache VC, Fu P, Yang K, Pan Q, Zhang Z, Xu J, Chute DJ, Thorstad WL, Faraji F, Bishop JA, Mehrad M, Castro PD, Sikora AG, Thompson LDR, Chernock RD, Lang Kuhs KA, Wasman JK, Luo JR, Adelstein DJ, Koyfman SA, Lewis JS, Madabhushi A. Image analysis reveals differences in tumor multinucleations in Black and White patients with human papillomavirus-associated oropharyngeal squamous cell carcinoma. Cancer 128(21):3831-3842, 2022. e-Pub 2022. PMID: 36066461.
- Liu Y, Kramer JR, Sandulache VC, Yu R, Li G, Chen L, Yusuf ZI, Shi Y, Pyarajan S, Tsavachidis S, Jiao L, Mierzwa ML, Chiao E, Mowery YM, Shuman A, Shete S, Sikora AG, White DL. Immunogenetic Determinants of Susceptibility to Head and Neck Cancer in the Million Veteran Program Cohort. Cancer Res. e-Pub 2022. PMID: 36378845.
- Ahmed KM, Veeramachaneni R, Deng D, Putluri N, Putluri V, Cardenas MF, Wheeler DA, Decker WK, Frederick AI, Kazi S, Sikora AG, Sandulache VC, Frederick MJ. Glutathione peroxidase 2 is a metabolic driver of the tumor immune microenvironment and immune checkpoint inhibitor response. J Immunother Cancer 10(8), 2022. e-Pub 2022. PMID: 36002187.
- Mazul AL, Hartman CM, Mowery YM, Kramer JR, White DL, Royse KE, Raychaudhury S, Sandulache VC, Ahmed ST, Zevallos JP, Richardson PA, Sikora AG, Chiao EY. Risk and incidence of head and neck cancers in veterans living with HIV and matched HIV-negative veterans. Cancer. e-Pub 2022. PMID: 35867552.
- Shi Y, Xie T, Wang B, Wang R, Cai Y, Yuan B, Gleber-Netto FO, Tian X, Rodriguez-Rosario AE, Osman AA, Wang J, Pickering CR, Ren X, Sikora AG, Myers JN, Rangel R. Mutant p53 drives an immune cold tumor immune microenvironment in oral squamous cell carcinoma. Commun Biol 5(1):757, 2022. e-Pub 2022. PMID: 35902768.
- Vyas A, Gomez-Casal R, Cruz-Rangel S, Villanueva H, Sikora AG, Rajagopalan P, Basu D, Pacheco J, Hammond GRV, Kiselyov K, Duvvuri U. Lysosomal inhibition sensitizes TMEM16A-expressing cancer cells to chemotherapy. Proc Natl Acad Sci U S A 119(12):e2100670119, 2022. e-Pub 2022. PMID: 35286200.
- Wilde DC, Castro PD, Bera K, Lai S, Madabhushi A, Corredor G, Koyuncu C, Lewis JS, Lu C, Frederick MJ, Frederick AM, Haugen AE, Zevallos JP, Sturgis EM, Shi J, Huang AT, Hernandez DJ, Skinner HD, Kemnade JO, Yu W, Sikora AG, Sandulache VC. Oropharyngeal cancer outcomes correlate with p16 status, multinucleation and immune infiltration. Mod Pathol. e-Pub 2022. PMID: 35184149.
- Kaminagakura E, Tango RN, Cruz-Perez D, Bonan R, Yamamoto de Almeida L, de Almeida Lança ML, Bonan P, Martins H, Takahama A, Ito FA, Coutinho-Camillo CM, Lourenço SV, Caneppele T, Sikora AG, Kowalski LP, Young S. Oral squamous cell carcinoma outcome in adolescent/young adult: Systematic review and meta-analysis. Head Neck 44(2):548-561, 2022. e-Pub 2022. PMID: 34808012.
- Villanueva H, Sikora AG. The Chicken Embryo Chorioallantoic Membrane (CAM): A Versatile Tool for the Study of Patient-Derived Xenografts. Methods Mol Biol 2471:209-220, 2022. e-Pub 2022. PMID: 35175599.
- Hoffman MR, Patro A, Huang L, Chen S, Berry LD, Gelbard A, Francis DO, Airway Collaborative NA. Impact of Adjuvant Medical Therapies on Surgical Outcomes in Idiopathic Subglottic Stenosis. Laryngoscope 131(12):E2880-E2886, 2021. e-Pub 2021. PMID: 34117778.
- Akama-Garren EH, Morris ZS, Sikora AG, Weichselbaum R, Schoenfeld JD. Prospective clinical investigation of the efficacy of combination radiotherapy with immune checkpoint inhibition. Int J Radiat Oncol Biol Phys 111(5):1165-1175, 2021. e-Pub 2021. PMID: 34411638.
- Kimura K, Du L, Berry LD, Huang L, Chen S, Francis DO, Gelbard A, Airway Collaborative NA. Modeling Recurrence in Idiopathic Subglottic Stenosis With Mobile Peak Expiratory Flow. Laryngoscope 131(12):E2841-E2848, 2021. e-Pub 2021. PMID: 34309022.
- Lee J, Huang LC, Berry LD, Anderson C, Amin MR, Benninger MS, Blumin JH, Bock JM, Bryson PC, Castellanos PF, Chen SC, Clary MS, Cohen SM, Crawley BK, Dailey SH, Daniero JJ, de Alarcon A, Donovan DT, Edell ES, Ekbom DC, Fink DS, Franco RA, Garrett CG, Guardiani EA, Hillel AT, Hoffman HT, Hogikyan ND, Howell RJ, Hussain LK, Johns MM, Kasperbauer JL, Khosla SM, Kinnard C, Kupfer RA, Langerman AJ, Lentz RJ, Lorenz RR, Lott DG, Lowery AS, Makani SS, Maldonado F, Mannion K, Matrka L, McWhorter AJ, Merati AL, Mori M, Netterville JL, O'Dell K, Ongkasuwan J, Postma GN, Reder LS, Rohde SL, Richardson BE, Rickman OB, Rosen CA, Rutter MJ, Sandhu GS, Schindler JS, Schneider GT, Shah RN, Sikora AG, Sinard RJ, Smith ME, Smith LJ, Soliman AMS, Sveinsdóttir S, Van Daele DJ, Veivers D, Verma SP, Weinberger PM, Weissbrod PA, Wootten CT, Shyr Y, Francis DO, Gelbard A. Association of Social Determinants of Health with Time to Diagnosis and Treatment Outcomes in Idiopathic Subglottic Stenosis. Ann Otol Rhinol Laryngol 130(10):3489421995283, 2021. e-Pub 2021. PMID: 33629608.
- Shi Y, Xie TX, Leach DG, Wang B, Young S, Osman AA, Sikora AG, Ren X, Hartgerink JD, Myers JN, Rangel R. Local Anti-PD-1 Delivery Prevents Progression of Premalignant Lesions in a 4NQO-Oral Carcinogenesis Mouse Model. Cancer Prev Res (Phila) 14(8):767-778, 2021. e-Pub 2021. PMID: 34021022.
- Warren EAK, Anil J, Castro PD, Kemnade J, Suzuki M, Hegde M, Hicks J, Yu W, Sandulache V, Sikora AG. Human epidermal growth factor receptor 2 expression in head and neck squamous cell carcinoma: Variation within and across primary tumor sites, and implications for antigen-specific immunotherapy. Head Neck 43(7):1983-1994, 2021. e-Pub 2021. PMID: 33660372.
- Hebert KA, Jaramillo S, Yu W, Wang M, Veeramachaneni R, Sandulache VC, Sikora AG, Bonnen MD, Annapragada AV, Corry D, Kheradmand F, Pandita RK, Ludwig MS, Pandita TK, Huang S, Coarfa C, Grimm SL, Perera D, Miles G, Ghebre YT. Esomeprazole enhances the effect of ionizing radiation to improve tumor control. Oncotarget 12(14):1339-1353, 2021. e-Pub 2021. PMID: 34262645.
- Veeramachaneni R, Yu W, Newton JM, Kemnade JO, Skinner HD, Sikora AG, Sandulache VC. Metformin generates profound alterations in systemic and tumor immunity with associated antitumor effects. J Immunother Cancer 9(7), 2021. e-Pub 2021. PMID: 34230113.
- Miles BA, Posner MR, Gupta V, Teng MS, Bakst RL, Yao M, Misiukiewicz KJ, Chai RL, Sharma S, Westra WH, Kim-Schulze S, Dayal B, Sobotka S, Sikora AG, Som PM, Genden EM. De-Escalated Adjuvant Therapy After Transoral Robotic Surgery for Human Papillomavirus-Related Oropharyngeal Carcinoma: The Sinai Robotic Surgery (SIRS) Trial. Oncologist 26(6):504-513, 2021. e-Pub 2021. PMID: 33675133.
- Gupta R, Rady PL, Sikora AG, Tyring SK. The role of human papillomavirus in the pathogenesis of sinonasal inverted papilloma: a narrative review. Rev Med Virol 31(3):e2178, 2021. e-Pub 2021. PMID: 33048407.
- Demaria S, Guha C, Schoenfeld J, Morris Z, Monjazeb A, Sikora A, Crittenden M, Shiao S, Khleif S, Gupta S, Formenti SC, Vikram B, Coleman C, Ahmed MM. Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose?. J Immunother Cancer 9(4):e002038, 2021. e-Pub 2021. PMID: 33827904.
- Koyuncu CF, Lu C, Bera K, Zhang Z, Xu J, Toro P, Corredor G, Chute D, Fu P, Thorstad WL, Faraji F, Bishop JA, Mehrad M, Castro PD, Sikora AG, Thompson LD, Chernock RD, Lang Kuhs KA, Luo J, Sandulache V, Adelstein DJ, Koyfman S, Lewis JS, Madabhushi A. Computerized tumor multinucleation index (MuNI) is prognostic in p16+ oropharyngeal carcinoma: A multi-site validation study. J Clin Invest 131(8), 2021. e-Pub 2021. PMID: 33651718.
- Huang C, Chen L, Savage SR, Eguez RV, Dou Y, Li Y, da Veiga Leprevost F, Jaehnig EJ, Lei JT, Wen B, Schnaubelt M, Krug K, Song X, Cieslik M, Chang HY, Wyczalkowski MA, Li K, Colaprico A, Li QK, Clark DJ, Hu Y, Cao L, Pan J, Wang Y, Cho KC, Shi Z, Liao Y, Jiang W, Anurag M, Ji J, Yoo S, Zhou DC, Liang WW, Wendl M, Vats P, Carr SA, Mani DR, Zhang Z, Qian J, Chen XS, Pico AR, Wang P, Chinnaiyan AM, Ketchum KA, Kinsinger CR, Robles AI, An E, Hiltke T, Mesri M, Thiagarajan M, Weaver AM, Sikora AG, Lubinski J, Wierzbicka M, Wiznerowicz M, Satpathy S, Gillette MA, Miles G, Ellis MJ, Omenn GS, Rodriguez H, Boja ES, Dhanasekaran SM, Ding L, Nesvizhskii AI, El-Naggar AK, Chan DW, Zhang H, Zhang B, Analysis Consortium CPT. Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma. Cancer Cell 39(3):361-379.e16, 2021. e-Pub 2021. PMID: 33417831.
- Gelbard A, Wanjalla C, Wootten CT, Drake WP, Lowery AS, Wheeler DA, Cardenas MF, Sikora AG, Pathak RR, McDonnell W, Mallal S, Pilkinton M. The Proximal Airway Is a Reservoir for Adaptive Immunologic Memory in Idiopathic Subglottic Stenosis. Laryngoscope 131(3):610-617, 2021. e-Pub 2021. PMID: 32603507.
- Leach DG, Dharmaraj N, Lopez-Silva TL, Venzor JR, Pogostin BH, Sikora AG, Hartgerink JD, Young S. Biomaterial-Facilitated Immunotherapy for Established Oral Cancers. ACS Biomater Sci Eng 7(2):415-421, 2021. e-Pub 2021. PMID: 33470801.
- Mazul AL, Hartman C, Kramer J, White DL, Royse K, Raychaudhury S, Sandulache V, Ahmed ST, Richardson P, Sikora AG, Chiao E. Incidence and survival for oropharynx and non-oropharynx head and neck cancers among veterans living with HIV. Cancer Med 9(24):9326-9335, 2020. e-Pub 2020. PMID: 33094910.
- Uzunparmak B, Gao M, Lindemann A, Erikson K, Wang L, Lin E, Frank SJ, Gleber-Netto FO, Zhao M, Skinner HD, Newton J, Sikora AG, Myers JN, Pickering CR. Caspase 8 loss radiosensitizes head and neck squamous cell carcinoma to SMAC mimetic induced necroptosis. JCI Insight 5(23), 2020. e-Pub 2020. PMID: 33108350.
- Mullany LK, Rohira AD, Leach JP, Kim JH, Monroe TO, Ortiz AR, Stork B, Gaber MW, Sarkar P, Sikora AG, Rosengart TK, York B, Song Y, Dacso CC, Lonard DM, Martin JF, O'Malley BW. A steroid receptor coactivator stimulator (MCB-613) attenuates adverse remodeling after myocardial infarction. Proc Natl Acad Sci U S A 117(49):31353-31364, 2020. e-Pub 2020. PMID: 33229578.
- Vantaku V, Putluri V, Bader DA, Maity S, Ma J, Arnold JM, Rajapakshe K, Donepudi SR, von Rundstedt FC, Devarakonda V, Dubrulle J, Karanam B, McGuire SE, Stossi F, Jain AK, Coarfa C, Cao Q, Sikora AG, Villanueva H, Kavuri SM, Lotan Y, Sreekumar A, Putluri N. Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression. Oncogene 39(40):6265-6285, 2020. e-Pub 2020. PMID: 31383940.
- Vantaku V, Putluri V, Bader DA, Maity S, Ma J, Arnold JM, Rajapakshe K, Donepudi SR, von Rundstedt FC, Devarakonda V, Dubrulle J, Karanam B, McGuire SE, Stossi F, Jain AK, Coarfa C, Cao Q, Sikora AG, Villanueva H, Kavuri SM, Lotan Y, Sreekumar A, Putluri N. Correction: Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression. Oncogene 39(40):6387-6392, 2020. e-Pub 2020. PMID: 32820250.
- Paez-Mayorga J, Capuani S, Hernandez N, Farina M, Chua CYX, Blanchard R, Sizovs A, Liu HC, Fraga DW, Niles JA, Salazar HF, Corradetti B, Sikora AG, Kloc M, Li XC, Gaber AO, Nichols JE, Grattoni A. Neovascularized implantable cell homing encapsulation platform with tunable local immunosuppressant delivery for allogeneic cell transplantation. Biomaterials 257:120232, 2020. e-Pub 2020. PMID: 32768727.
- Elhalawani H, Mohamed ASR, Elgohari B, Lin TA, Sikora AG, Lai SY, Abusaif A, Phan J, Morrison WH, Gunn GB, Rosenthal DI, Garden AS, Fuller CD, Sandulache VC. Tobacco exposure as a major modifier of oncologic outcomes in human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma. BMC Cancer 20(1):912, 2020. e-Pub 2020. PMID: 32967643.
- Ferrarotto R, Bell D, Rubin ML, Hutcheson KA, Johnson JM, Goepfert RP, Phan J, Elamin YY, Torman DK, Warneke CL, Hessel AC, Garden AS, Myers JN, Johnson FM, Lee JJ, Sikora AG, Gillison ML, Glisson BS, Gross ND. Impact of Neoadjuvant Durvalumab with or without Tremelimumab on CD8+ Tumor Lymphocyte Density, Safety, and Efficacy in Patients with Oropharynx Cancer: CIAO Trial Results. Clin Cancer Res 26(13):3211-3219, 2020. e-Pub 2020. PMID: 32269052.
- Krupar R, Watermann C, Idel C, Ribbat-Idel J, Offermann A, Pasternack H, Kirfel J, Sikora AG, Perner S. In silico analysis reveals EP300 as a panCancer inhibitor of anti-tumor immune response via metabolic modulation. Sci Rep 10(1):9389, 2020. e-Pub 2020. PMID: 32523042.
- Arnold JM, Gu F, Ambati CR, Rasaily U, Ramirez-Pena E, Joseph R, Manikkam M, San Martin R, Charles C, Pan Y, Chatterjee SS, Den Hollander P, Zhang W, Nagi C, Sikora AG, Rowley D, Putluri N, Zhang XH, Karanam B, Mani SA, Sreekumar A. UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression. Oncogene 39(15):3089-3101, 2020. e-Pub 2020. PMID: 31308490.
- Arnold JM, Gu F, Ambati CR, Rasaily U, Ramirez-Pena E, Joseph R, Manikkam M, Martin RS, Charles C, Pan Y, Chatterjee SS, Den Hollander P, Zhang W, Nagi C, Sikora AG, Rowley D, Putluri N, Zhang XH, Karanam B, Mani SA, Sreekumar A. Correction: UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression. Oncogene 39(15):3226-3228, 2020. e-Pub 2020. PMID: 32214199.
- Frederick M, Skinner HD, Kazi SA, Sikora AG, Sandulache VC. High expression of oxidative phosphorylation genes predicts improved survival in squamous cell carcinomas of the head and neck and lung. Sci Rep 10(1):6380, 2020. e-Pub 2020. PMID: 32286489.
- Sandulache VC, Lei YL, Heasley LE, Chang M, Amos CI, Sturgis EM, Graboyes E, Chiao EY, Rogus-Pulia N, Lewis J, Madabhushi A, Frederick MJ, Sabichi A, Ittmann M, Yarbrough WG, Chung CH, Ferrarotto R, Mai W, Skinner HD, Duvvuri U, Gerngross P, Sikora AG. Innovations in risk-stratification and treatment of Veterans with oropharynx cancer; roadmap of the 2019 Field Based Meeting. Oral Oncol 102:104440, 2020. e-Pub 2020. PMID: 31648864.
- Kemnade JO, Elhalawani H, Castro P, Yu J, Lai S, Ittmann M, Mohamed ASR, Lai SY, Fuller CD, Sikora AG, Sandulache VC. CD8 infiltration is associated with disease control and tobacco exposure in intermediate-risk oropharyngeal cancer. Sci Rep 10(1):243, 2020. e-Pub 2020. PMID: 31937831.
- Leach DG, Newton JM, Florez MA, Lopez-Silva TL, Jones AA, Young S, Sikora AG, Hartgerink JD. Drug-mimicking nanofibrous peptide hydrogel for inhibition of inducible nitric oxide synthase. ACS Biomater Sci Eng 5(12):6755-6765, 2019. e-Pub 2019. PMID: 33304997.
- Pham N, Ludwig MS, Wang M, Ebrahimpour A, Bonnen MD, Diwan AH, Kim SJ, Bryan J, Newton JM, Sikora AG, Donovan DT, Sandulache V, Ghebre YT. Topical Esomeprazole Mitigates Radiation-Induced Dermal Inflammation and Fibrosis. Radiat Res 192(5):473-482, 2019. e-Pub 2019. PMID: 31415221.
- Montealegre JR, Varier I, Bracamontes CG, Dillon LM, Guillaud M, Sikora AG, Follen M, Adler-Storthz K, Scheurer ME. Racial/ethnic variation in the prevalence of vaccine-related human papillomavirus genotypes. Ethn Health 24(7):804-815, 2019. e-Pub 2019. PMID: 28870103.
- Gelbard A, Anderson C, Berry LD, Amin MR, Benninger MS, Blumin JH, Bock JM, Bryson PC, Castellanos PF, Chen SC, Clary MS, Cohen SM, Crawley BK, Dailey SH, Daniero JJ, de Alarcon A, Donovan DT, Edell ES, Ekbom DC, Fernandes-Taylor S, Fink DS, Franco RA, Garrett CG, Guardiani EA, Hillel AT, Hoffman HT, Hogikyan ND, Howell RJ, Huang LC, Hussain LK, Johns MM, Kasperbauer JL, Khosla SM, Kinnard C, Kupfer RA, Langerman AJ, Lentz RJ, Lorenz RR, Lott DG, Lowery AS, Makani SS, Maldonado F, Mannion K, Matrka L, McWhorter AJ, Merati AL, Mori MC, Netterville JL, O'Dell K, Ongkasuwan J, Postma GN, Reder LS, Rohde SL, Richardson BE, Rickman OB, Rosen CA, Rutter MJ, Sandhu GS, Schindler JS, Schneider GT, Shah RN, Sikora AG, Sinard RJ, Smith ME, Smith LJ, Soliman AMS, Sveinsdóttir S, Van Daele DJ, Veivers D, Verma SP, Weinberger PM, Weissbrod PA, Wootten CT, Shyr Y, Francis DO. Comparative Treatment Outcomes for Patients With Idiopathic Subglottic Stenosis. JAMA Otolaryngol Head Neck Surg:1-10. e-Pub 2019. PMID: 31670805.
- Harms A, Kansara S, Stach C, Richardson PA, Chen G, Lai S, Sikora AG, Parke R, Donovan D, Chiao E, Skinner H, Sandulache VC. Swallowing Function in Survivors of Oropharyngeal Cancer Is Associated With Advanced T Classification. Ann Otol Rhinol Laryngol 128(8):696-703, 2019. e-Pub 2019. PMID: 30913911.
- Newton JM, Hanoteau A, Liu HC, Gaspero A, Parikh F, Gartrell-Corrado RD, Hart TD, Laoui D, Van Ginderachter JA, Dharmaraj N, Spanos WC, Saenger Y, Young S, Sikora AG. Immune microenvironment modulation unmasks therapeutic benefit of radiotherapy and checkpoint inhibition. J Immunother Cancer 7(1):216, 2019. e-Pub 2019. PMID: 31409394.
- Vantaku V, Dong J, Ambati CR, Perera D, Donepudi SR, Amara CS, Putluri V, Ravi SS, Robertson MJ, Piyarathna DWB, Villanueva M, von Rundstedt FC, Karanam B, Ballester LY, Terris MK, Bollag RJ, Lerner SP, Apolo AB, Villanueva H, Lee M, Sikora AG, Lotan Y, Sreekumar A, Coarfa C, Putluri N. Multi-omics Integration Analysis Robustly Predicts High-Grade Patient Survival and Identifies CPT1B Effect on Fatty Acid Metabolism in Bladder Cancer. Clin Cancer Res 25(12):3689-3701, 2019. e-Pub 2019. PMID: 30846479.
- Carrero I, Liu HC, Sikora AG, Milosavljevic A. Histoepigenetic analysis of HPV- and tobacco-associated head and neck cancer identifies both subtype-specific and common therapeutic targets despite divergent microenvironments. Oncogene 38(19):3551-3568, 2019. e-Pub 2019. PMID: 30655605.
- Jung J, Cho KJ, Naji AK, Clemons KN, Wong CO, Villanueva M, Gregory S, Karagas NE, Tan L, Liang H, Rousseau MA, Tomasevich KM, Sikora AG, Levental I, van der Hoeven D, Zhou Y, Hancock JF, Venkatachalam K. HRAS-driven cancer cells are vulnerable to TRPML1 inhibition. EMBO Rep 20(4), 2019. e-Pub 2019. PMID: 30787043.
- Piyarathna DWB, Balasubramanian A, Arnold JM, Lloyd SM, Karanam B, Castro P, Ittmann MM, Putluri N, Navone N, Jones JA, Yu W, Sandulache VC, Sikora AG, Michailidis G, Sreekumar A. ERR1 and PGC1α associated mitochondrial alterations correlate with pan-cancer disparity in African Americans. J Clin Invest 129(6):2351-2356, 2019. e-Pub 2019. PMID: 30920960.
- Badr H, Sobrero M, Chen J, Kotz T, Genden E, Sikora AG, Miles B. Associations between pre-, post-, and peri-operative variables and health resource use following surgery for head and neck cancer. Oral Oncol 90:102-108, 2019. e-Pub 2019. PMID: 30846167.
- Hanoteau A, Newton JM, Krupar R, Huang C, Liu HC, Gaspero A, Gartrell RD, Saenger YM, Hart TD, Santegoets SJ, Laoui D, Spanos C, Parikh F, Jayaraman P, Zhang B, Van der Burg SH, Van Ginderachter JA, Melief CJM, Sikora AG. Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy. J Immunother Cancer 7(1):10, 2019. e-Pub 2019. PMID: 30646957.
- Dharmaraj N, Piotrowski SL, Huang C, Newton JM, Golfman LS, Hanoteau A, Koshy ST, Li AW, Pulikkathara MX, Zhang B, Burks JK, Mooney DJ, Lei YL, Sikora AG, Young S. Anti-tumor immunity induced by ectopic expression of viral antigens is transient and limited by immune escape. Oncoimmunology 8(4):e1568809, 2019. e-Pub 2019. PMID: 30906661.
- Krishna S, Ulrich P, Wilson E, Parikh F, Narang P, Yang S, Read AK, Kim-Schulze S, Park JG, Posner M, Wilson Sayres MA, Sikora A, Anderson KS. Human Papilloma Virus Specific Immunogenicity and Dysfunction of CD8+ T Cells in Head and Neck Cancer. Cancer Res 78(21):6159-6170, 2018. e-Pub 2018. PMID: 30154146.
- Krupar R, Schreiber C, Offermann A, Lengerke C, Sikora AG, Thorns C, Perner S. In silico analysis of anti-leukemia immune response and immune evasion in acute myeloid leukemia. Leuk Lymphoma 59(10):2493-2496, 2018. e-Pub 2018. PMID: 29431550.
- Suk R, Mahale P, Sonawane K, Sikora AG, Chhatwal J, Schmeler KM, Sigel K, Cantor SB, Chiao EY, Deshmukh AA. Trends in Risks for Second Primary Cancers Associated With Index Human Papillomavirus-Associated Cancers. JAMA Netw Open 1(5):e181999, 2018. e-Pub 2018. PMID: 30646145.
- Farina M, Chua CYX, Ballerini A, Thekkedath U, Alexander JF, Rhudy JR, Torchio G, Fraga D, Pathak RR, Villanueva M, Shin CS, Niles JA, Sesana R, Demarchi D, Sikora AG, Acharya GS, Gaber AO, Nichols JE, Grattoni A. Transcutaneously refillable, 3D-printed biopolymeric encapsulation system for the transplantation of endocrine cells. Biomaterials 177:125-138, 2018. e-Pub 2018. PMID: 29886385.
- Richardson PA, Kansara S, Chen GG, Sabichi A, Sikora AG, Parke RB, Donovan DT, Chiao E, Sandulache VC. Treatment Patterns in Veterans with Laryngeal and Oropharyngeal Cancer and Impact on Survival. Laryngoscope Investig Otolaryngol 3(4):275-282, 2018. e-Pub 2018. PMID: 30186958.
- Patel RS, Mohr T, Hartman C, Stach C, Sikora AG, Zevallos JP, Sandulache VC. Tracheoesophageal Prosthesis Use Is Associated With Improved Overall Quality of Life in Veterans With Laryngeal Cancer. Ann Otol Rhinol Laryngol 127(7):421-428, 2018. e-Pub 2018. PMID: 29756480.
- Newton JM, Hanoteau A, Sikora AG. Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors. J Vis Exp(136), 2018. e-Pub 2018. PMID: 29939180.
- Leach DG, Dharmaraj N, Piotrowski SL, Lopez-Silva TL, Lei YL, Sikora AG, Young S, Hartgerink JD. STINGel: Controlled release of a cyclic dinucleotide for enhanced cancer immunotherapy. Biomaterials 163:67-75, 2018. e-Pub 2018. PMID: 29454236.
- Patro A, Guerrini CJ, Huang AT, Sikora AG. The Patient Who Continues to Smoke On-Treatment: An Ethical Dilemma. Otolaryngol Head Neck Surg 158(3):469-472, 2018. e-Pub 2018. PMID: 29337655.
- Newton JM, Flores-Arredondo JH, Suki S, Ware MJ, Krzykawska-Serda M, Agha M, Law JJ, Sikora AG, Curley SA, Corr SJ. Non-Invasive Radiofrequency Field Treatment of 4T1 Breast Tumors Induces T-cell Dependent Inflammatory Response. Sci Rep 8(1):3474, 2018. e-Pub 2018. PMID: 29472563.
- Krupar R, Hautmann MG, Pathak RR, Varier I, McLaren C, Gaag D, Hellerbrand C, Evert M, Laban S, Idel C, Sandulache V, Perner S, Bosserhoff AK, Sikora AG. Immunometabolic Determinants of Chemoradiotherapy Response and Survival in Head and Neck Squamous Cell Carcinoma. Am J Pathol 188(1):72-83, 2018. e-Pub 2018. PMID: 29107073.
- Jayaraman P, Parikh F, Newton JM, Hanoteau A, Rivas C, Krupar R, Rajapakshe K, Pathak R, Kanthaswamy K, MacLaren C, Huang S, Coarfa C, Spanos C, Edwards DP, Parihar R, Sikora AG. TGF-β1 programmed myeloid-derived suppressor cells (MDSC) acquire immune-stimulating and tumor killing activity capable of rejecting established tumors in combination with radiotherapy. Oncoimmunology 7(10):e1490853, 2018. e-Pub 2018. PMID: 30288358.
- San Martin R, Pathak R, Jain A, Jung SY, Hilsenbeck SG, Piña-Barba MC, Sikora AG, Pienta KJ, Rowley DR. Tenascin-C and Integrin α9 Mediate Interactions of Prostate Cancer with the Bone Microenvironment. Cancer Res 77(21):5977-5988, 2017. e-Pub 2017. PMID: 28916657.
- Sonawane K, Suk R, Chiao EY, Chhatwal J, Qiu P, Wilkin T, Nyitray AG, Sikora AG, Deshmukh AA. Oral Human Papillomavirus Infection: Differences in Prevalence Between Sexes and Concordance With Genital Human Papillomavirus Infection, NHANES 2011 to 2014. Ann Intern Med 167(10):714-724, 2017. e-Pub 2017. PMID: 29049523.
- Rosewell Shaw A, Porter CE, Watanabe N, Tanoue K, Sikora A, Gottschalk S, Brenner MK, Suzuki M. Adenovirotherapy Delivering Cytokine and Checkpoint Inhibitor Augments CAR T Cells against Metastatic Head and Neck Cancer. Mol Ther 25(11):2440-2451, 2017. e-Pub 2017. PMID: 28974431.
- Chew EY, Hartman CM, Richardson PA, Zevallos JP, Sikora AG, Kramer JR, Chiao EY. Risk factors for oropharynx cancer in a cohort of HIV-infected veterans. Oral Oncol 68:60-66, 2017. e-Pub 2017. PMID: 28438295.
- Laban S, Giebel G, Klümper N, Schröck A, Doescher J, Spagnoli G, Thierauf J, Theodoraki MN, Remark R, Gnjatic S, Krupar R, Sikora AG, Litjens G, Grabe N, Kristiansen G, Bootz F, Schuler PJ, Brunner C, Brägelmann J, Hoffmann TK, Perner S. MAGE expression in head and neck squamous cell carcinoma primary tumors, lymph node metastases and respective recurrences-implications for immunotherapy. Oncotarget 8(9):14719-14735, 2017. e-Pub 2017. PMID: 28146422.
- Deshmukh KS, Suk R, Chiao EY, Chhatwal J, Qui P, Wilkin T, Nyitray AG, Sikora AG, Deshmukh AA. Oral Human Papillomavirus Infection: Differences in Prevalence Between Sexes and Concordance with Genital Human Papillomavirus Infection: Differences in Prevalence Between Sexes and Concordance with Genital Human Papillomavirus Infection, NHANES 2011- 2014. Ann Internal Medicine 167(10):714-724, 2017. e-Pub 2017.
- Nelson C, Lee J, Ko K, Sikora AG, Bonnen MD, Enkhbaatar P, Ghebre YT. Therapeutic Efficacy of Esomeprazole in Cotton Smoke-Induced Lung Injury Model. Front Pharmacol 8:16, 2017. e-Pub 2017. PMID: 28184197.
- Kass JI, Giraldez L, Gooding W, Choby G, Kim S, Miles B, Teng M, Sikora AG, Johnson JT, Myers EN, Duvvuri U, Genden EM, Ferris RL. Oncologic outcomes of surgically treated early-stage oropharyngeal squamous cell carcinoma. Head Neck 38(10):1467-71, 2016. e-Pub 2016. PMID: 27080244.
- Yin W, Duluc D, Joo H, Xue Y, Gu C, Wang Z, Wang L, Ouedraogo R, Oxford L, Clark A, Parikh F, Kim-Schulze S, Thompson-Snipes L, Lee SY, Beauregard C, Woo JH, Zurawski S, Sikora AG, Zurawski G, Oh S. Therapeutic HPV Cancer Vaccine Targeted to CD40 Elicits Effective CD8+ T-cell Immunity. Cancer Immunol Res 4(10):823-834, 2016. e-Pub 2016. PMID: 27485136.
- Ramer I, Varier I, Zhang D, Demicco EG, Posner MR, Misiukiewicz K, Genden EM, Miles BA, Teng MS, Sikora AG. Racial disparities in incidence of human papillomavirus-associated oropharyngeal cancer in an urban population. Cancer Epidemiol 44:91-95, 2016. e-Pub 2016. PMID: 27518158.
- Varier I, Keeley BR, Krupar R, Patsias A, Dong J, Gupta N, Parasher AK, Genden EM, Miles BA, Teng M, Bakst RL, Gupta V, Misiukiewicz KJ, Chiao EY, Scheurer ME, Laban S, Zhang D, Ye F, Cui M, Demicco EG, Posner MR, Sikora AG. Clinical characteristics and outcomes of oropharyngeal carcinoma related to high-risk non-human papillomavirus16 viral subtypes. Head Neck 38(9):1330-7, 2016. e-Pub 2016. PMID: 27080140.
- Veit JA, Heine D, Thierauf J, Lennerz J, Shetty S, Schuler PJ, Whiteside T, Beutner D, Meyer M, Grünewald I, Ritter G, Gnjatic S, Sikora AG, Hoffmann TK, Laban S. Expression and clinical significance of MAGE and NY-ESO-1 cancer-testis antigens in adenoid cystic carcinoma of the head and neck. Head Neck 38(7):1008-16, 2016. e-Pub 2016. PMID: 26874246.
- de Almeida JR, Moskowitz AJ, Miles BA, Goldstein DP, Teng MS, Sikora AG, Gupta V, Posner M, Genden EM. Cost-effectiveness of transoral robotic surgery versus (chemo)radiotherapy for early T classification oropharyngeal carcinoma: A cost-utility analysis. Head Neck 38(4):589-600, 2016. e-Pub 2016. PMID: 25488048.
- Wang J, Peng L, Zhang R, Zheng Z, Chen C, Cheung KL, Cui M, Bian G, Xu F, Chiang D, Hu Y, Chen Y, Lu G, Yang J, Zhang H, Yang J, Zhu H, Chen SH, Liu K, Zhou MM, Sikora AG, Li L, Jiang B, Xiong H. 5-Fluorouracil targets thymidylate synthase in the selective suppression of TH17 cell differentiation. Oncotarget 7(15):19312-26, 2016. e-Pub 2016. PMID: 27027355.
- Stucken CL, de Almeida JR, Sikora AG, Tong CC, Genden EM. Impact of human papillomavirus and smoking on survival outcomes after transoral robotic surgery. Head Neck 38(3):380-6, 2016. e-Pub 2016. PMID: 25351893.
- Parasher AK, Kidwai SM, Schorn VJ, Goljo E, Weinberg AD, Richards-Kortum R, Sikora AG, Iloreta AM, Govindaraj S, Miles BA. High-resolution microendoscope imaging of inverted papilloma and normal sinonasal mucosa: evaluation of interobserver concordance. Int Forum Allergy Rhinol 5(12):1136-40, 2015. e-Pub 2015. PMID: 26228817.
- Li M, Pathak RR, Lopez-Rivera E, Friedman SL, Aguirre-Ghiso JA, Sikora AG. The In Ovo Chick Chorioallantoic Membrane (CAM) Assay as an Efficient Xenograft Model of Hepatocellular Carcinoma. J Vis Exp(104), 2015. e-Pub 2015. PMID: 26484588.
- Rettig EM, Wentz A, Posner MR, Gross ND, Haddad RI, Gillison ML, Fakhry C, Quon H, Sikora AG, Stott WJ, Lorch JH, Gourin CG, Guo Y, Xiao W, Miles BA, Richmon JD, Andersen PE, Misiukiewicz KJ, Chung CH, Gerber JE, Rajan SD, D'Souza G. Prognostic Implication of Persistent Human Papillomavirus Type 16 DNA Detection in Oral Rinses for Human Papillomavirus-Related Oropharyngeal Carcinoma. JAMA Oncol 1(7):907-15, 2015. e-Pub 2015. PMID: 26226294.
- Miles BA, Patsias A, Quang T, Polydorides AD, Richards-Kortum R, Sikora AG. Operative margin control with high-resolution optical microendoscopy for head and neck squamous cell carcinoma. Laryngoscope 125(10):2308-16, 2015. e-Pub 2015. PMID: 26059758.
- Lee H, Ruane D, Law K, Ho Y, Garg A, Rahman A, Esterházy D, Cheong C, Goljo E, Sikora AG, Mucida D, Chen BK, Govindraj S, Breton G, Mehandru S. Phenotype and function of nasal dendritic cells. Mucosal Immunol 8(5):1083-98, 2015. e-Pub 2015. PMID: 25669151.
- Patsias A, Giraldez-Rodriguez L, Polydorides AD, Richards-Kortum R, Anandasabapathy S, Quang T, Sikora AG, Miles B. Feasibility of transoral robotic-assisted high-resolution microendoscopic imaging of oropharyngeal squamous cell carcinoma. Head Neck 37(8):E99-102, 2015. e-Pub 2015. PMID: 25327825.
- Chen W, Ye F, Cui M, Sikora AG, Wang X, Wang P, Cui X, Guo X, Zhu W, Zhang DY. Protein marker profiling in different T classification in laryngeal squamous cell carcinoma. Head Neck 37(3):357-65, 2015. e-Pub 2015. PMID: 24753215.
- Lu G, Zhang R, Geng S, Peng L, Jayaraman P, Chen C, Xu F, Yang J, Li Q, Zheng H, Shen K, Wang J, Liu X, Wang W, Zheng Z, Qi CF, Si C, He JC, Liu K, Lira SA, Sikora AG, Li L, Xiong H. Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization. Nat Commun 6:6676, 2015. e-Pub 2015. PMID: 25813085.
- Moskalenko M, Pan M, Fu Y, de Moll EH, Hashimoto D, Mortha A, Leboeuf M, Jayaraman P, Bernardo S, Sikora AG, Wolchok J, Bhardwaj N, Merad M, Saenger Y. Requirement for innate immunity and CD90? NK1.1? lymphocytes to treat established melanoma with chemo-immunotherapy. Cancer Immunol Res 3(3):296-304, 2015. e-Pub 2015. PMID: 25600438.
- Parikh F, Duluc D, Imai N, Clark A, Misiukiewicz K, Bonomi M, Gupta V, Patsias A, Parides M, Demicco EG, Zhang DY, Kim-Schulze S, Kao J, Gnjatic S, Oh S, Posner MR, Sikora AG. Chemoradiotherapy-induced upregulation of PD-1 antagonizes immunity to HPV-related oropharyngeal cancer. Cancer Res 74(24):7205-16, 2014. e-Pub 2014. PMID: 25320012.
- Jayaraman P, Alfarano MG, Svider PF, Parikh F, Lu G, Kidwai S, Xiong H, Sikora AG. iNOS expression in CD4+ T cells limits Treg induction by repressing TGFβ1: combined iNOS inhibition and Treg depletion unmask endogenous antitumor immunity. Clin Cancer Res 20(24):6439-51, 2014. e-Pub 2014. PMID: 25278453.
- Cheng J, Kleinberger AJ, Sikora A. Fusobacterium necrophorum in a pediatric retropharyngeal abscess: A case report and review of the literature. Ear Nose Throat J 93(12):E22-4, 2014. e-Pub 2014. PMID: 25531849.
- Levovitz C, Chen D, Ivansson E, Gyllensten U, Finnigan JP, Alshawish S, Zhang W, Schadt EE, Posner MR, Genden EM, Boffetta P, Sikora AG. TGFβ receptor 1: an immune susceptibility gene in HPV-associated cancer. Cancer Res 74(23):6833-44, 2014. e-Pub 2014. PMID: 25273091.
- Badr H, Gupta V, Sikora A, Posner M. Psychological distress in patients and caregivers over the course of radiotherapy for head and neck cancer. Oral Oncol 50(10):1005-11, 2014. e-Pub 2014. PMID: 25091150.
- Megwalu UC, Sikora AG. Survival outcomes in advanced laryngeal cancer. JAMA Otolaryngol Head Neck Surg 140(9):855-60, 2014. e-Pub 2014. PMID: 25144163.
- Keeley BR, Islami F, Pourshams A, Poustchi H, Pak JS, Brennan P, Khademi H, Genden EM, Abnet CC, Dawsey SM, Boffetta P, Malekzadeh R, Sikora AG. Prediagnostic serum levels of inflammatory biomarkers are correlated with future development of lung and esophageal cancer. Cancer Sci 105(9):1205-11, 2014. e-Pub 2014. PMID: 25040886.
- Vila PM, Stucken CL, Morris LG, Posner MR, Genden EM, Boffetta P, Sikora AG. Reduced impact of nodal metastases as a prognostic factor for tonsil cancer in the HPV era. Eur Arch Otorhinolaryngol 271(9):2523-9, 2014. e-Pub 2014. PMID: 24190760.
- Jiang N, Muhammad C, Ho Y, Del Signore AG, Sikora AG, Malkin BD. Prevalence of severe obstructive sleep apnea in pediatric adenotonsillectomy patients. Laryngoscope 124(8):1975-8, 2014. e-Pub 2014. PMID: 24668559.
- de Almeida JR, Villanueva NL, Moskowitz AJ, Miles BA, Teng MS, Sikora A, Gupta V, Posner M, Genden EM. Preferences and utilities for health states after treatment for oropharyngeal cancer: transoral robotic surgery versus definitive (chemo)radiotherapy. Head Neck 36(7):923-33, 2014. e-Pub 2014. PMID: 23595774.
- Bradley J, Jiang N, Levy L, Richards-Kortum R, Sikora A, Smouha E. High-resolution microendoscope images of middle ear cholesteatoma and surrounding tissue: evaluation of interobserver concordance. Otolaryngol Head Neck Surg 150(4):654-8, 2014. e-Pub 2014. PMID: 24415492.
- Lopez-Rivera E, Jayaraman P, Parikh F, Davies MA, Ekmekcioglu S, Izadmehr S, Milton DR, Chipuk JE, Grimm EA, Estrada Y, Aguirre-Ghiso J, Sikora AG. Inducible nitric oxide synthase drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2. Cancer Res 74(4):1067-78, 2014. e-Pub 2014. PMID: 24398473.
- Villanueva NL, de Almeida JR, Sikora AG, Miles BA, Genden EM. Transoral robotic surgery for the management of oropharyngeal minor salivary gland tumors. Head Neck 36(1):28-33, 2014. e-Pub 2014. PMID: 23554023.
- Tong CL, Jiang N, Cannan MD, Wu M, Sikora AG, Altman W. Lymphocytic Response and Inducible Nitric Oxide Synthase in WTC-Exposed Chronic Rhinosinusitis. Oncoloty and Rhinology, 2014. e-Pub 2014.
- Jang DW, Sikora AG, Leytin A. Thyroglossal duct cyst carcinoma: case report and review of the literature. Ear Nose Throat J 92(9):E12-4, 2013. e-Pub 2013. PMID: 24057908.
- Svider PF, Mady LJ, Husain Q, Sikora AG, Setzen M, Baredes S, Eloy JA. Geographic differences in academic promotion practices, fellowship training, and scholarly impact. Am J Otolaryngol 34(5):464-70, 2013. e-Pub 2013. PMID: 23702316.
- Morris LG, Sikora AG, Tosteson TD, Davies L. The increasing incidence of thyroid cancer: the influence of access to care. Thyroid 23(7):885-91, 2013. e-Pub 2013. PMID: 23517343.
- Yang J, Zhang R, Lu G, Shen Y, Peng L, Zhu C, Cui M, Wang W, Arnaboldi P, Tang M, Gupta M, Qi CF, Jayaraman P, Zhu H, Jiang B, Chen SH, He JC, Ting AT, Zhou MM, Kuchroo VK, Morse HC, Ozato K, Sikora AG, Xiong H. T cell–derived inducible nitric oxide synthase switches off Th17 cell differentiation. J Exp Med 210(7):1447-62, 2013. e-Pub 2013. PMID: 23797094.
- Jain KS, Sikora AG, Baxi SS, Morris LG. Synchronous cancers in patients with head and neck cancer: risks in the era of human papillomavirus-associated oropharyngeal cancer. Cancer 119(10):1832-7, 2013. e-Pub 2013. PMID: 23423883.
- Levy LL, Jiang N, Smouha E, Richards-Kortum R, Sikora AG. Optical imaging with a high-resolution microendoscope to identify cholesteatoma of the middle ear. Laryngoscope 123(4):1016-20, 2013. e-Pub 2013. PMID: 23299781.
- Anvekar RA, Asciolla JJ, Lopez-Rivera E, Floros KV, Izadmehr S, Elkholi R, Belbin G, Sikora AG, Chipuk JE. Sensitization to the mitochondrial pathway of apoptosis augments melanoma tumor cell responses to conventional chemotherapeutic regimens. Cell Death Dis 3:e420, 2012. e-Pub 2012. PMID: 23152056.
- Vila PM, Park CW, Pierce MC, Goldstein GH, Levy L, Gurudutt VV, Polydorides AD, Godbold JH, Teng MS, Genden EM, Miles BA, Anandasabapathy S, Gillenwater AM, Richards-Kortum R, Sikora AG. Discrimination of benign and neoplastic mucosa with a high-resolution microendoscope (HRME) in head and neck cancer. Ann Surg Oncol 19(11):3534-9, 2012. e-Pub 2012. PMID: 22492225.
- Jayaraman P, Parikh F, Lopez-Rivera E, Hailemichael Y, Clark A, Ma G, Cannan D, Ramacher M, Kato M, Overwijk WW, Chen SH, Umansky VY, Sikora AG. Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release. J Immunol 188(11):5365-76, 2012. e-Pub 2012. PMID: 22529296.
- Tong CC, Lau KH, Rivera M, Cannan D, Aguirre-Ghiso J, Sikora AG, Gupta V, Forsythe K, Ko EC, Misiukiewicz K, Gurudutt V, Teng MS, Packer SH, Genden EM, Kao J. Prognostic significance of p16 in locoregionally advanced head and neck cancer treated with concurrent 5-fluorouracil, hydroxyurea, cetuximab and intensity-modulated radiation therapy. Oncol Rep 27(5):1580-6, 2012. e-Pub 2012. PMID: 22322320.
- Levy LL, Vila PM, Park RW, Schwarz R, Polydorides AD, Teng MS, Gurudutt VV, Genden EM, Miles B, Anandasabapathy S, Gillenwater AM, Richards-Kortum R, Sikora AG. High-Resolution Optical Imaging of Benign and Malignant Mucosa in the Upper Aerodigestive Tract: An Atlas for Image-Guided Surgery. ISRN Minim Invasive Surg 2012, 2012. e-Pub 2012. PMID: 23641314.
- Fu S, Rivera M, Ko EC, Sikora AG, Chen CT, Vu HL, Cannan D, Eisenstein S, Rosenstein BS, Aguirre-Ghiso J, Chen SH, Kao J. Combined Inhibition of Epidermal Growth Factor Receptor and Cyclooxygenase-2 as a Novel Approach to Enhance Radiotherapy. J Cell Sci Ther 1(2), 2011. e-Pub 2011. PMID: 23483082.
- Jethanamest D, Vila PM, Sikora AG, Morris LG. Predictors of survival in mucosal melanoma of the head and neck. Ann Surg Oncol 18(10):2748-56, 2011. e-Pub 2011. PMID: 21476106.
- Genden EM, Kotz T, Tong CC, Smith C, Sikora AG, Teng MS, Packer SH, Lawson WL, Kao J. Transoral robotic resection and reconstruction for head and neck cancer. Laryngoscope 121(8):1668-74, 2011. e-Pub 2011. PMID: 21792953.
- Morris LG, Sikora AG, Hayes RB, Patel SG, Ganly I. Anatomic sites at elevated risk of second primary cancer after an index head and neck cancer. Cancer Causes Control 22(5):671-9, 2011. e-Pub 2011. PMID: 21327458.
- Morris LG, Sikora AG, Patel SG, Hayes RB, Ganly I. Second primary cancers after an index head and neck cancer: subsite-specific trends in the era of human papillomavirus-associated oropharyngeal cancer. J Clin Oncol 29(6):739-46, 2011. e-Pub 2011. PMID: 21189382.
- Sikora AG, Gelbard A, Davies MA, Sano D, Ekmekcioglu S, Kwon J, Hailemichael Y, Jayaraman P, Myers JN, Grimm EA, Overwijk WW. Targeted inhibition of inducible nitric oxide synthase inhibits growth of human melanoma in vivo and synergizes with chemotherapy. Clin Cancer Res 16(6):1834-44, 2010. e-Pub 2010. PMID: 20215556.
- Morris LG, Shaha AR, Tuttle RM, Sikora AG, Ganly I. Tall-cell variant of papillary thyroid carcinoma: a matched-pair analysis of survival. Thyroid 20(2):153-8, 2010. e-Pub 2010. PMID: 20151822.
- Sikora AG, Jaffarzad N, Hailemichael Y, Gelbard A, Stonier SW, Schluns KS, Frasca L, Lou Y, Liu C, Andersson HA, Hwu P, Overwijk WW. IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity. J Immunol 182(12):7398-407, 2009. e-Pub 2009. PMID: 19494262.
- Sikora AG, Morris LG, Sturgis EM. Bidirectional association of anogenital and oral cavity/pharyngeal carcinomas in men. Arch Otolaryngol Head Neck Surg 135(4):402-5, 2009. e-Pub 2009. PMID: 19380365.
- Morris LG, Sikora AG, Myssiorek D, DeLacure MD. The basis of racial differences in the incidence of thyroid cancer. Ann Surg Oncol 15(4):1169-76, 2008. e-Pub 2008. PMID: 18246401.
- Sikora AG, Shnayder Y, Yee H, DeLacure MD. Oropharyngeal kaposi sarcoma in related persons negative for human immunodeficiency virus. Ann Otol Rhinol Laryngol 117(3):172-6, 2008. e-Pub 2008. PMID: 18444476.
- Liu C, Lou Y, Lizée G, Qin H, Liu S, Rabinovich B, Kim GJ, Wang YH, Ye Y, Sikora AG, Overwijk WW, Liu YJ, Wang G, Hwu P. Plasmacytoid dendritic cells induce NK cell-dependent, tumor antigen-specific T cell cross-priming and tumor regression in mice. J Clin Invest 118(3):1165-75, 2008. e-Pub 2008. PMID: 18259609.
- Morris LG, Miglietta MA, Sikora AG, Okun MN, Roland JT. Emergency parotidectomy for penetrating zone III neck trauma. Arch Surg 142(12):1206-8, 2007. e-Pub 2007. PMID: 18086989.
- Morris LG, Sikora AG, Kuriakose MA, DeLacure MD. Tamoxifen therapy for aggressive fibromatosis of the posterior triangle of the neck. Otolaryngol Head Neck Surg 136(4):674-6, 2007. e-Pub 2007. PMID: 17418276.
- Jethanamest D, Morris LG, Sikora AG, Kutler DI. Esthesioneuroblastoma: a population-based analysis of survival and prognostic factors. Arch Otolaryngol Head Neck Surg 133(3):276-80, 2007. e-Pub 2007. PMID: 17372086.
- Le BT, Setlur J, Sikora AG, Lee KC. Mycosis fungoides: a case of tonsil involvement. Arch Otolaryngol Head Neck Surg 132(7):794-6, 2006. e-Pub 2006. PMID: 16847192.
- Liebeskind A, Sikora AG, Komisar A, Slavit D, Fried K. Rates of malignancy in incidentally discovered thyroid nodules evaluated with sonography and fine-needle aspiration. J Ultrasound Med 24(5):629-34, 2005. e-Pub 2005. PMID: 15840794.
- Sikora AG, Toniolo P, DeLacure MD. The changing demographics of head and neck squamous cell carcinoma in the United States. Laryngoscope 114(11):1915-23, 2004. e-Pub 2004. PMID: 15510014.
- Kuriakose MA, Chen WT, He ZM, Sikora AG, Zhang P, Zhang ZY, Qiu WL, Hsu DF, McMunn-Coffran C, Brown SM, Elango EM, Delacure MD, Chen FA. Selection and validation of differentially expressed genes in head and neck cancer. Cell Mol Life Sci 61(11):1372-83, 2004. e-Pub 2004. PMID: 15170515.
- Sikora AG, Lee KC. Otolaryngologic manifestations of immunodeficiency. Otolaryngol Clin North Am 36(4):647-72, 2003. e-Pub 2003. PMID: 14567058.
- Sikora AG, Mulvihill M. Trends in mortality due to legal intervention in the United States, 1979 through 1997. Am J Public Health 92(5):841-3, 2002. e-Pub 2002. PMID: 11988457.
- Liu JS, John GR, Sikora A, Lee SC, Brosnan CF. Modulation of interleukin-1beta and tumor necrosis factor alpha signaling by P2 purinergic receptors in human fetal astrocytes. J Neurosci 20(14):5292-9, 2000. e-Pub 2000. PMID: 10884313.
- Sikora A, Fleischman AR. Physician participation in capital punishment: a question of professional integrity. J Urban Health 76(4):400-8, 1999. e-Pub 1999. PMID: 10609590.
- Sikora A, Liu J, Brosnan C, Buell G, Chessel I, Bloom BR. Cutting edge: purinergic signaling regulates radical-mediated bacterial killing mechanisms in macrophages through a P2X7-independent mechanism. J Immunol 163(2):558-61, 1999. e-Pub 1999. PMID: 10395640.
- Redlich CA, Rockwell S, Chung JS, Sikora AG, Kelley M, Mayne ST. Vitamin A inhibits radiation-induced pneumonitis in rats. J Nutr 128(10):1661-4, 1998. e-Pub 1998. PMID: 9772133.
Invited Articles
- Morris, Z, Demaria, S, Monjazeb, AM, Formenti, SC, Weichselbaum, RR, Welsh, J, Enderling, H, Schoenfeld, JD, Brody, J, McGee, HM, Mondini, M, Kent, MS, Young, K, Galluzzi, L, Karam, SD, Theelen, WS, Chang, JY, Huynh, MA, Daib, A, Pitroda, SP, Chung, C, Serre, R, Grassberger, C, Deng, J, Sodji, QH, Nguyen, A, Patel, RB, Krebs, SS, Kalbasi, A, Kerr, C, Vanpouille-Box, C, Vick, L, Aguilera, T, Ong, IM, Herrera, FG, Menon, H, Smart, DD, Ahmed, J, Gartrell, RD, Roland, CL, Fekrmandi, F, Chakraborty, B, Bent, EH, Berg, TJ, Hutson, A, Khleif, SN, Sikora, AG, Fong, L. Proceedings of the National Cancer Institute Workshop on combining immunotherapy with radiotherapy. The lancet oncology 26(3):e152-e170, 2025. e-Pub 2025. PMID: 40049206.
- Hussein, NI, Molina, AH, Sunga, GM, Amit, M, Lei, YL, Zhao, X, Hartgerink, JD, Sikora, AG, Young, S. Localized intratumoral delivery of immunomodulators for oral cancer and oral potentially malignant disorders. Oral Oncology 158, 2024. e-Pub 2024. PMID: 39137489.
- Na’ara, S, Andrews, C, Sikora, AG, Williams, MD, Chambers, MS, Myers, JN, Amit, M. Oral Pre-malignancy. Current oncology reports 26(9):1047-1056, 2024. e-Pub 2024. PMID: 38865005.
- Gillenwater, AM, Vigneswaran, N, Sikora, AG. Assessing the Role of Inflammation in Oral Tongue Carcinogenesis. Journal of Clinical Oncology 42(15):1729-1730, 2024. e-Pub 2024. PMID: 38635939.
- Annapragada A, Sikora AG, Marathe H, Liu S, Demetriou M, Fong L, Gao J, Kufe D, Morris ZS, Vilar E, Sharon E, Hutson A, Odunsi K. The Cancer Moonshot Immuno-Oncology Translational Network (IOTN) at age 5: Accelerating Cancer Immunotherapies. J Natl Cancer Inst. e-Pub 2023. PMID: 37572314.
- Sunga GM, Hartgerink J, Sikora AG, Young S. Enhancement of Immunotherapies in Head and Neck Cancers Using Biomaterial-Based Treatment Strategies. Tissue Eng Part C Methods 29(6):257-275, 2023. e-Pub 2023. PMID: 37183412.
- Rangel R, Pickering CR, Sikora AG, Spiotto MT. Genetic Changes Driving Immunosuppressive Microenvironments in Oral Premalignancy. Front Immunol 13:840923, 2022. e-Pub 2022. PMID: 35154165.
- Sandulache VC, Wilde DC, Sturgis EM, Chiao EY, Sikora AG. A Hidden Epidemic of "Intermediate Risk" Oropharynx Cancer. Laryngoscope Investig Otolaryngol 4(6):617-623, 2019. e-Pub 2019. PMID: 31890879.
- Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL. The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC). J Immunother Cancer 7(1):184, 2019. e-Pub 2019. PMID: 31307547.
- Li L, Mok H, Jhaveri P, Bonnen MD, Sikora AG, Eissa NT, Komaki RU, Ghebre YT. Anticancer therapy and lung injury: molecular mechanisms. Expert Rev Anticancer Ther 18(10):1041-1057, 2018. e-Pub 2018. PMID: 29996062.
- DeBord LC, Pathak RR, Villaneuva M, Liu HC, Harrington DA, Yu W, Lewis MT, Sikora AG. The chick chorioallantoic membrane (CAM) as a versatile patient-derived xenograft (PDX) platform for precision medicine and preclinical research. Am J Cancer Res 8(8):1642-1660, 2018. e-Pub 2018. PMID: 30210932.
- Liao K, Blumenthal-Barby J, Sikora AG. Factors Influencing Head and Neck Surgical Oncologists' Transition from Curative to Palliative Treatment Goals. Otolaryngol Head Neck Surg 156(1):46-51, 2017. e-Pub 2017. PMID: 27625024.
- Ghebre YT, Yakubov E, Wong WT, Krishnamurthy P, Sayed N, Sikora AG, Bonnen MD. Vascular Aging: Implications for Cardiovascular Disease and Therapy. Transl Med (Sunnyvale) 6(4), 2016. e-Pub 2016. PMID: 28932625.
- Hashemi-Sadraei N, Sikora AG, Brizel DM. Immunotherapy and Checkpoint Inhibitors in Recurrent and Metastatic Head and Neck Cancer. Am Soc Clin Oncol Educ Book 35:e277-82, 2016. e-Pub 2016. PMID: 27249733.
- Misiukiewicz K, Camille N, Gupta V, Bakst R, Teng M, Miles B, Genden E, Sikora AG, Posner M. The role of HPV status in recurrent/metastatic squamous cell carcinoma of the head and neck. Clin Adv Hematol Oncol 12(12):812-9, 2014. e-Pub 2014. PMID: 25674839.
- Finnigan JP, Sikora AG. Counseling the patient with potentially HPV-related newly diagnosed head and neck cancer. Curr Oncol Rep 16(3):375, 2014. e-Pub 2014. PMID: 24488548.
- Bonomi M, Patsias A, Posner M, Sikora AG. The role of inflammation in head and neck cancer. Adv Exp Med Biol 816:107-27, 2014. e-Pub 2014. PMID: 24818721.
- Grimm EA, Sikora AG, Ekmekcioglu S. Molecular pathways: inflammation-associated nitric-oxide production as a cancer-supporting redox mechanism and a potential therapeutic target. Clin Cancer Res 19(20):5557-63, 2013. e-Pub 2013. PMID: 23868870.
- Chu A, Genden E, Posner M, Sikora AG. A patient-centered approach to counseling patients with head and neck cancer undergoing human papillomavirus testing: a clinician's guide. Oncologist 18(2):180-9, 2013. e-Pub 2013. PMID: 23345545.
- Tong CC, Kao J, Sikora AG. Recognizing and reversing the immunosuppressive tumor microenvironment of head and neck cancer. Immunol Res 54(1-3):266-74, 2012. e-Pub 2012. PMID: 22454102.
- Sikora AG, Hailemichael Y, Overwijk WW. Conference scene: immune effector mechanisms in tumor immunity. Immunotherapy 4(2):141-3, 2012. e-Pub 2012. PMID: 22339456.
- Kao J, Ko EC, Eisenstein S, Sikora AG, Fu S, Chen SH. Targeting immune suppressing myeloid-derived suppressor cells in oncology. Crit Rev Oncol Hematol 77(1):12-9, 2011. e-Pub 2011. PMID: 20304669.
- Prince A, Aguirre-Ghizo J, Genden E, Posner M, Sikora AG. Head and neck squamous cell carcinoma: new translational therapies. Mt Sinai J Med 77(6):684-99, 2010. e-Pub 2010. PMID: 21105129.
- Vu HL, Sikora AG, Fu S, Kao J. HPV-induced oropharyngeal cancer, immune response and response to therapy. Cancer Lett 288(2):149-55, 2010. e-Pub 2010. PMID: 19628331.
- Kao J, Sikora AG, Fu S. Dual EGFR and COX-2 inhibition as a novel approach to targeting head and neck squamous cell carcinoma. Curr Cancer Drug Targets 9(8):931-7, 2009. e-Pub 2009. PMID: 20025602.
- Sikora AG. Commentary: Progress in Youth Violence Prevention. Einstein Quarterly Journal of Biology and Medicine(14):157-159, 1997. e-Pub 1997.
Review Articles
- Souto EP, Dobrolecki LE, Villanueva H, Sikora AG, Lewis MT. In Vivo Modeling of Human Breast Cancer Using Cell Line and Patient-Derived Xenografts. J Mammary Gland Biol Neoplasia. e-Pub 2022. PMID: 35697909.
- Wan, P, Ongkasuwan, J, Martinez, JA, Sandulache, VC, Deng, D, Jiang, J, Sikora, AG, Altman, KW. Biomarkers for Malignant Potential in Vocal Fold Leukoplakia. Otolaryngology - Head and Neck Surgery (United States) 164(4):751-758, 2021. e-Pub 2021. PMID: 32988279.
Abstracts
- Krupar R, Imai N, Miles B, Genden E, Misiukiewicz YS, Demicco EG, Patel J, Herrera MC, Parikh F, Donovan M, Kim-Schulze S, Posner M, Gnjatic S, Sikora AG. Changes in local and peripheral T cell diversity after HPV E7 antigen-expressing Listeria-based immunotherapy (ADXS11-001) prior to robotic surgery for HPV-positive oropharyngeal cancer. American Association for Cancer Research (AACR) Annual Meeting, 2018. e-Pub 2018.
- Sikora AG. Optimal Neoadjuvant and Adjuvant Integration of Immune Checkpoint Inhibitors in Surgical Head and Neck Cancer. American Society of Clinical Oncology (ASCO) Annual Meeting, 2016. e-Pub 2016.
- Krupar R, Imai N, Miles B, Genden E, Misiukiewicz YS, Demicco EG, Patel J, Herrera MC, Parikh F, Donovan M, Kim-Schulze S, Posner M, Gnjatic S, Sikora AG. HPV E7 antigen-expressing Listyeria-basesd immunotherapy (ADXS11-001) prior to robotic surgery for HPV-positive oropharyngeal cancer enhances HPV-specific T cell immunity. American Association for Cancer Research (AACR) Annual Meeting, 2016. e-Pub 2016.
- Gnjatic S, Donovan M, Genden EM, Misiukiewicz K, Krupar R, Saenger YM, Demicco EG, Posner MR, Sikora AG. Window of opportunity trial of HPV E7 antigen-expressing Listeria-pbased therapeutic vaccination prior to robotic surgery for HPV-positive oropharyngeal cancer. American Society of Clinical Oncology Annual Meeting, 2015. e-Pub 2015.
- Townes T, Gross N, Goepfert R, Choi K, Hessel A, Barbon C, Hutcheson K, Sikora A, Lango M. Improved Primary Site Identification with Implementation of a Standardized Algorithm for Head and Neck Squamous Cell Carcinoma of Unknown Primary. American Head and Neck Society at COSM.
- Gnjatic S, Donovan M, Genden EM, Misiukiewicz K, Krupar R, Saenger YM, Demicco EG, Posner MR, Sikora AG. Window of opportunity trial of HPV E7 antigen-expressing Listeria-pbased therapeutic vaccination prior to robotic surgery for HPV-positive oropharyngeal cancer. American Society of Clinical Oncology Annual Meeting.
- Krupar R, Imai N, Miles B, Genden E, Misiukiewicz YS, Demicco EG, Patel J, Herrera MC, Parikh F, Donovan M, Kim-Schulze S, Posner M, Gnjatic S, Sikora AG. HPV E7 antigen-expressing Listyeria-basesd immunotherapy (ADXS11-001) prior to robotic surgery for HPV-positive oropharyngeal cancer enhances HPV-specific T cell immunity. American Association for Cancer Research (AACR) Annual Meeting.
- Sikora AG. Optimal Neoadjuvant and Adjuvant Integration of Immune Checkpoint Inhibitors in Surgical Head and Neck Cancer. American Society of Clinical Oncology (ASCO) Annual Meeting.
- Krupar R, Imai N, Miles B, Genden E, Misiukiewicz YS, Demicco EG, Patel J, Herrera MC, Parikh F, Donovan M, Kim-Schulze S, Posner M, Gnjatic S, Sikora AG. Changes in local and peripheral T cell diversity after HPV E7 antigen-expressing Listeria-based immunotherapy (ADXS11-001) prior to robotic surgery for HPV-positive oropharyngeal cancer. Association for Cancer Research (AACR) Annual Meeting.
- Guimaraes de Sousa L, Mota Siqueira J, McGrail D, Marques-Piubelli M, Lazar Neto F, Ferri Borgogno S, Daumas Nunes F, Matos L, Paulo Kowalski L, Oliveira Hoff C, Dai H, Mitani Y, Li K, Williams MD, Lin S-Y, El-Naggar AK, Sikora AG, Burks J, Gillison ML, Ferrarotto R. The immunological milieu of oropharyngeal squamous cell Carcinoma (OPC) according to HPV and smoking status and its influence on prognosis. 2024 ASCO Annual Meeting.
Book Chapters
- Newton JM, Young S, Sikora A. Materials-Based Cancer Immunotherapies. In: Principles of Regenerative Medicine. Elseiver, 2018.
- Genden E, Lawson W, Sikora A. Oral Cavity Reconstruction. In: Reconstruction of the Head and Neck. Theime, 2012.
- Levy L, Sikora A. Immunobiology and Immunotherapy of Melanoma. In: Cutaneous Malignancy of the Head and Neck: A Multidisciplinary Approach. Plural Publishing, 2011.
- Sikora A, r W. Angiofibromas and Vascular Tumors of the Skull Base. In: Comprehensive Management of Skull Base Tumors. Marcell-Decker, 2009.
- Korovin G, Sikora A. Otorhinolaryngology. In: Sports Medicine: A Comoprehensive Approach. Second. Elsevier Press, 2004.
- Sikora A, Rothstein S, Garay K, Spiegel R. Tuberculosis of the Head and Neck. In: Tuberculosis. Lipincott Williams and Wilkins, 2003.
Patents
- An efficient, Scalable Patient-Derived Xenograft System Based on a Chick Chorioallantoice Membrane (CCA) in Vivo Model. Patent Number: BAYM.PO172US.P1.
- Materials and Methods Relating to Immunogenic Epitopes from Human Papillomavirus. Patent Number: 208192-9044-US01.
- Immune stimulatory function and anti-tumor activity of TGF-β1 primed MDSC. Patent Number: BAYM.P0167WOUS.P1.
Patient Reviews
CV information above last modified April 02, 2026