Angela Ting, Ph.D.
Department of Epigenetics and Molecular Carcinogenesis, Division of Discovery Science
Present Title & Affiliation
Primary Appointment
Professor, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2005 | Johns Hopkins University School of Medicine, Baltimore, Maryland, US, Ph.D. in Cellular and Molecular Medicine |
| 2001 | University of British Columbia, Vancouver, CA, BS in Genetics with Honors |
Postgraduate Training
| 2005-2007 | Postdoctoral Fellow, Johns Hopkins University School of Medicine, Baltimore, Maryland |
Experience & Service
Faculty Academic Appointments
Associate Professor, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2023 - 2026
Adjunct Associate Professor, Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, 2023 - 2024
Associate Professor, Department of Genetics & Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, 2015 - 2022
Associate Professor, Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, 2015 - 2022
Associate Staff, Department of Genomic Medicine, Cleveland Clinic, Cleveland, OH, 2014 - 2022
Associate Staff, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, 2014 - 2022
Adjunct Associate Professor, Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, OH, 2014 - 2022
Adjunct Assistant Professor, Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, OH, 2012 - 2014
Assistant Staff, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, 2008 - 2014
Assistant Professor, Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, 2008 - 2015
Assistant Professor, Department of Genetics & Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, 2008 - 2015
Assistant Staff, Department of Genomic Medicine, Cleveland Clinic, Cleveland, OH, 2007 - 2014
Administrative Appointments/Responsibilities
Chair ad interim, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2024 - 2025
Program Leader, Department of Cancer Genomics & Epigenomics, Case Comprehensive Cancer Center, Cleveland, OH, 2022 - 2022
Extramural Institutional Committee Activities
Member, GSBS Student Scholarship Committee, The University of Texas MD Anderson Cancer Center UTHealth Houston, Graduate School of Biomedical Sciences, 2025 - Present
Member, Genetics & Epigenetics Program Steering Committee, The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, 2024 - Present
Member, Chair Search Advisory Committee, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, 2024 - 2024
Member, Organizing Committee, Genetics and Epigenetics & Immunology Graduate Programs Spring Career Symposium, The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, 2024 - 2024
Grant Reviewer, 2022 LRI Accelerator Grant, Cleveland Clinic, 2022 - 2022
Member, Case Comprehensive Cancer Center, Annual Retreat Planning Committee, Case Western Reserve University, 2022 - 2022
Grant Reviewer, Cleveland Clinic, Cancer Biology Pilot Funding, Cleveland Clinic, 2021 - 2021
Member, Cleveland Clinic, VeloSano Pilot Award Grant Review Committee, Cleveland Clinic, 2021 - 2021
Member, Cleveland Clinic, Cancer Biology Faculty Search Committee, Cleveland Clinic, 2020 - 2021
Member, Cleveland Clinic, VeloSano Pilot Award Grant Review Committee, Cleveland Clinic, 2019 - 2019
Member, Cleveland Clinic, Radiation Safety Committee, Cleveland Clinic, 2019 - 2022
Member, Case Comprehensive Cancer Center, Pilot Advisory Committee, Case Western Reserve University, 2019 - 2022
Member, Cleveland Clinic, Molecular Medicine Admissions Committee, Cleveland Clinic, 2018 - 2022
Member, Cleveland Clinic, Germline Genomics Faculty Search Committee, Cleveland Clinic, 2018 - 2019
Member, Cleveland Clinic, VeloSano Pilot Award Grant Review Committee, Cleveland Clinic, 2017 - 2017
Member, Case Comprehensive Cancer Center, Genomics Pilot Review Committee, Case Western Reserve University, 2017
Grant Reviewer, Cleveland Clinic, Research Program Committees (RPC), Cleveland Clinic, 2016 - 2021
Member, Case Western Reserve University School of Medicine, Clinical and Translational Science Collaborative (CTSC) Annual Pilot Review Committee, Case Western Reserve University, 2016 - 2017
Member, Cleveland Clinic, Lerner Research Institute Computer Committee, Cleveland Clinic, 2016 - 2022
Judge, Cleveland Clinic, Bumpus Award, Cleveland Clinic, 2016 - 2017
Judge, Cleveland Clinic, Molecular Medicine Research Showcase, Cleveland Clinic, 2014 - 2015
Member, Cleveland Clinic, Committee of Institutional Advancement, Cleveland Clinic, 2013 - 2015
Member, Cleveland Clinic, Molecular Medicine Admissions Committee, Cleveland Clinic, 2013 - 2015
Member, Case Western Reserve University, Clinical & Translational Science Awards (CTSA) Review Committee, Case Western Reserve University, 2012 - 2012
Member, Cleveland Clinic, The Elsa Albrecht Award Committee, Cleveland Clinic, 2010
Member, Cleveland Clinic, Graduate Student Award Committee for Basic Science, Cleveland Clinic, 2009
Editorial Activities
Editorial Board Member, Epigenetics, 2025 - Present
Editorial Board Member, Translational Oncology, 2021 - Present
Editorial Board Member, Frontiers Oncology, 2012 - 2023
Editorial Board Member, PLoS ONE, 2011 - 2023
Honors & Awards
| 2016 | Outstanding Women in Science, Endocrine Related Research |
| 2015 | Caregiver Award, Cleveland Clinic |
| 2014 | Caregiver Celebration Award of Excellence, Cleveland Clinic |
| 2011 | Innovator Award, Cleveland Clinic |
| 2007 | Selected Speaker for the “Future Leaders, New Directions” Special Symposium, American Association for Cancer Research |
| 1997 - 2000 | Dean’s Honour List, The University of British Columbia |
| 1997 - 1999 | Outstanding Student Initiative Scholarship of British Columbia, Province of British Columbia, Canada |
Professional Memberships
Grant & Contract Support
| Date: | 2026 - 2028 |
| Title: | Targeting ALCAM/CD6 Signaling to Overcome BCG Resistance in Non-muscle Invasive Bladder Cancer |
| Funding Source: | Department of Defense |
| Role: | Co-I |
| ID: | CA250431 |
| Date: | 2026 - 2027 |
| Title: | Study the role of retrotransposon-mediated polyadenylations in skin inflammation |
| Funding Source: | EMC Pilot Project |
| Role: | PI |
| ID: | TBD (Ting/Ge) |
| Date: | 2024 - 2029 |
| Title: | Interrogating the Role of Bacterial Methyl-modifying Enzymes in Pathoadaptation and Host Epigenetic Interference in Cancer |
| Funding Source: | NIH |
| Role: | Co-PI |
| ID: | R01CA290034 |
| Date: | 2023 - 2027 |
| Title: | 53BP1 regulates genome biology and cellular physiology through liquid phase separation |
| Funding Source: | NIH/NIGMS (S/C Case Western Reserve University) |
| Role: | Co-I |
| ID: | R01GM148662 |
| Date: | 2023 - 2028 |
| Title: | Activity and connectivity of hippocampal newborn neurons underlie alcohol withdrawal-associated syndromes |
| Funding Source: | NIH/NIAAA |
| Role: | Co-I |
| ID: | R01AA031028 |
| Date: | 2021 - 2026 |
| Title: | To establish correlation between maternal and newborn chromosome architecture |
| Funding Source: | Government of India, Ministry of Science & Technology |
| Role: | Formal Mentor |
| ID: | Ramalingaswami Re-entry Fellowship |
Selected Publications
Peer-Reviewed Articles
- Krylova A, Le NB, Ting AH. scPASU: A computational protocol for quantifying polyadenylation site usage and alternative polyadenylation from 3' scRNA-seq data. STAR Protoc 7(2):104544, 2026. e-Pub 2026. PMID: 42085187.
- Le, NB, Sona, S, Santo, B, Zhang, Y, Ou, R, Schweickart, RA, Kochat, V, Padron, WI, Rai, K, Lee, S, Yi, JM, Wessely, O, Lee, B, Ting, AH. Differentiation in the human urothelia is defined by distinct alternative polyadenylation. Cell Reports 45(1), 2026. e-Pub 2026. PMID: 41533515.
- Santo BA, Fink EE, Desprez PE, Lin YC, Eltemamy M, Wee A, Le NB, Krylova A, Tran U, Kochat V, Rai K, Strand DW, Wessely O, Lee BH, Ting AH. A poly(A) isoform-aware single-cell and spatial atlas defines fibroblast niches in the human bladder. bioRxiv, 2025. e-Pub 2025. PMID: 41473332.
- Juric I, Fink EE, Qiu H, Desprez PE, Ravi A, Holton M, Makarov V, Almassi N, Min B, Getz G, Chan TA, Alban T, Ting AH, Lee BH. Single-cell RNA-sequencing of BCG naive and recurrent non-muscle invasive bladder cancer reveals a CD6/ALCAM-mediated immune-suppressive pathway. NPJ Precis Oncol 9(1):318, 2025. e-Pub 2025. PMID: 41006678.
- Cadena LA, Luo KL, Otero-Perez CA, Fernandez SM, Huang YW, Zhao R, Lee DF, Ting AH, Ye F, You MJ, Lee SH. A TP53 Intron-Derived Peptide Promotes Tumor Survival. bioRxiv, 2025. e-Pub 2025. PMID: 40964364.
- Fink EE, Zhang Y, Santo B, Siddavatam A, Ou R, Nanavaty V, Lee BH, Ting AH. Heat shock induces alternative polyadenylation through dynamic DNA methylation and chromatin looping. Cell Stress Chaperones 30(4):100084, 2025. e-Pub 2025. PMID: 40412548.
- Santo B, Fink EE, Krylova AE, Lin YC, Eltemamy M, Wee A, Wessely O, Lee BH, Ting AH. Exploring the utility of snRNA-seq in profiling human bladder tissue: A comprehensive comparison with scRNA-seq. iScience 28(1):111628, 2025. e-Pub 2025. PMID: 39850354.
- Sona S, Bradley M, Ting AH. Protocols for single-cell RNA-seq and spatial gene expression integration and interactive visualization. STAR Protoc, 2023. e-Pub 2023. PMID: 36853708.
- Qiu H, Makarov V, Bolzenius JK, Halstead A, Parker Y, Wang A, Iyer GV, Wise H, Kim D, Thayaparan V, Lindner DJ, Haber GP, Ting AH, Ren B, Chan TA, Arora V, Solit DB, Lee BH. KDM6A loss triggers an epigenetic switch that disrupts urothelial differentiation and drives cell proliferation in bladder cancer. Cancer Res 83(6):814-829, 2023. e-Pub 2023. PMID: 36638328.
- Fink EE, Sona S, Lee BH, Ting AH. Processing and cryopreservation of human ureter tissues for single-cell and spatial transcriptomics assays. STAR Protoc 3(4):101854, 2022. e-Pub 2022. PMID: 36595885.
- Fink EE, Sona S, Tran U, Desprez PE, Bradley M, Qiu H, Eltemamy M, Wee A, Wolkov M, Nicolas M, Min B, Haber GP, Wessely O, Lee BH, Ting AH. Single-cell and spatial mapping Identify cell types and signaling Networks in the human ureter. Dev Cell 57(15):1899-1916.e6, 2022. e-Pub 2022. PMID: 35914526.
- Nanavaty V, Abrash EW, Hong C, Park S, Fink EE, Li Z, Sweet TJ, Bhasin JM, Singuri S, Lee BH, Hwang TH, Ting AH. DNA Methylation Regulates Alternative Polyadenylation via CTCF and the Cohesin Complex. Mol Cell 78(4):752-764.e6, 2020. e-Pub 2020. PMID: 32333838.
- Liang J, Zhou W, Sakre N, DeVecchio J, Ferrandon S, Ting AH, Bao S, Bissett I, Church J, Kalady MF. Epigenetically regulated miR-1247 functions as a novel tumour suppressor via MYCBP2 in methylator colon cancers. Br J Cancer 119(10):1267-1277, 2018. e-Pub 2018. PMID: 30318507.
- Sarvestani SK, Signs SA, Lefebvre V, Mack S, Ni Y, Morton A, Chan ER, Li X, Fox P, Ting AH, Kalady MF, Cruise M, Ashburn J, Stiene J, Lai W, Liska D, Xiang S, Huang EH. Cancer-predicting transcriptomic and epigenetic signatures revealed for ulcerative colitis in patient-derived epithelial organoids. Oncotarget 9(47):28717-28730, 2018. e-Pub 2018. PMID: 29983891.
- Do J, Kim D, Kim S, Valentin-Torres A, Dvorina N, Jang E, Nagarajavel V, DeSilva TM, Li X, Ting AH, Vignali DAA, Stohlman SA, Baldwin WM, Min B. Treg-specific IL-27Rα deletion uncovers a key role for IL-27 in Treg function to control autoimmunity. Proc Natl Acad Sci U S A 114(38):10190-10195, 2017. e-Pub 2017. PMID: 28874534.
- Bhasin JM, Ting AH. Goldmine integrates information placing genomic ranges into meaningful biological contexts. Nucleic Acids Res 44(12):5550-6, 2016. e-Pub 2016. PMID: 27257071.
- Yan H, Tang G, Wang H, Hao L, He T, Sun X, Ting AH, Deng A, Sun S. DNA methylation reactivates GAD1 expression in cancer by preventing CTCF-mediated polycomb repressive complex 2 recruitment. Oncogene 35(30):3995-4008, 2016. e-Pub 2016. PMID: 26549033.
Invited Articles
- Ting AH, Lee BH. 5mC: what goes on must come off. Nat Rev Mol Cell Biol 23(5):306, 2022. e-Pub 2022. PMID: 35217851.
- Ting AH. WOMEN IN CANCER PROFILE: Dude, where's my band?. Endocr Relat Cancer 23(11):P33-P35, 2016. e-Pub 2016. PMID: 27605445.
- Sweet TJ, Ting AH. WOMEN IN CANCER THEMATIC REVIEW: Diverse functions of DNA methylation: implications for prostate cancer and beyond. Endocr Relat Cancer 23(11):T169-T178, 2016. e-Pub 2016. PMID: 27605446.
Patient Reviews
CV information above last modified September 09, 2026