Angela Ting, Ph.D.
Department of Epigenetics and Molecular Carcinogenesis, Division of Discovery Science
Present Title & Affiliation
Primary Appointment
Interim Department Chair, Department of Epigenetics and Molecular Carcinogenesis, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, Texas
Associate Professor, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2005 | Johns Hopkins University School of Medicine, Baltimore, Maryland, US, Ph.D. in Cellular and Molecular Medicine |
| 2001 | University of British Columbia, Vancouver, CA, BS in Genetics with Honors |
Postgraduate Training
| 2005-2007 | Postdoctoral Fellow, Johns Hopkins University School of Medicine, Baltimore, Maryland |
Experience & Service
Academic Appointments
Adjunct Associate Professor, Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, 2023 - 2024
Associate Professor, Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, 2015 - 2022
Associate Professor, Department of Genetics & Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, 2015 - 2022
Associate Staff, Department of Genomic Medicine, Cleveland Clinic, Cleveland, OH, 2014 - 2022
Associate Staff, Department of Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, 2014 - 2022
Adjunct Associate Professor, Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, OH, 2012 - 2022
Assistant Staff, Department of Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, 2008 - 2014
Assistant Professor, Department of Genetics & Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, 2008 - 2015
Assistant Professor, Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, 2008 - 2015
Assistant Staff, Department of Genomic Medicine, Cleveland Clinic, Cleveland, OH, 2007 - 2014
Administrative Appointments/Responsibilities
Program Leader, Department of Cancer Genomics & Epigenomics, Case Comprehensive Cancer Center, Cleveland, OH, 2022 - 2022
Institutional Committee Activities
Member, Genetics & Epigenetics Program Steering Committee, 2024 - Present
Member, Organizing Committee, Genetics and Epigenetics & Immunology Graduate Programs Spring Career Symposium, 2024 - 2024
Member, Chair Search Advisory Committee, Department of Epigenetics and Molecular Carcinogenesis, 2024 - 2024
Grant Reviewer, 2022 LRI Accelerator Grant, 2022 - 2022
Member, Case Comprehensive Cancer Center, Annual Retreat Planning Committee, 2022 - 2022
Grant Reviewer, Cleveland Clinic, Cancer Biology Pilot Funding, 2021 - 2021
Member, Cleveland Clinic, VeloSano Pilot Award Grant Review Committee, 2021 - 2021
Member, Cleveland Clinic, Cancer Biology Faculty Search Committee, 2020 - 2021
Member, Cleveland Clinic, VeloSano Pilot Award Grant Review Committee, 2019 - 2019
Member, Case Comprehensive Cancer Center, Pilot Advisory Committee, 2019 - 2022
Member, Cleveland Clinic, Radiation Safety Committee, 2019 - 2022
Member, Cleveland Clinic, Germline Genomics Faculty Search Committee, 2018 - 2019
Member, Cleveland Clinic, Molecular Medicine Admissions Committee, 2018 - 2022
Member, Cleveland Clinic, VeloSano Pilot Award Grant Review Committee, 2017 - 2017
Member, Case Comprehensive Cancer Center, Genomics Pilot Review Committee, 2017 - 2017
Grant Reviewer, Cleveland Clinic, Research Program Committees (RPC), 2016 - 2021
Member, Case Western Reserve University School of Medicine, Clinical and Translational Science Collaborative (CTSC) Annual Pilot Review Committee, 2016 - 2017
Judge, Cleveland Clinic, Bumpus Award, 2016 - 2017
Member, Cleveland Clinic, Lerner Research Institute Computer Committee, 2016 - 2022
Judge, Cleveland Clinic, Molecular Medicine Research Showcase, 2014 - 2015
Member, Cleveland Clinic, Molecular Medicine Admissions Committee, 2013 - 2015
Member, Cleveland Clinic, Committee of Institutional Advancement, 2013 - 2015
Member, Case Western Reserve University, Clinical & Translational Science Awards (CTSA) Review Committee, 2012 - 2012
Member, Cleveland Clinic, The Elsa Albrecht Award Committee, 2010 - 2010
Member, Cleveland Clinic, Graduate Student Award Committee for Basic Science, 2009 - 2009
Honors & Awards
| 2016 | Outstanding Women in Science, Endocrine Related Research |
| 2015 | Caregiver Award, Cleveland Clinic |
| 2014 | Caregiver Celebration Award of Excellence, Cleveland Clinic |
| 2011 | Innovator Award, Cleveland Clinic |
| 2007 | Selected Speaker for the “Future Leaders, New Directions” Special Symposium, American Association for Cancer Research |
| 1997 | Dean’s Honour List, The University of British Columbia |
| 1997 | Outstanding Student Initiative Scholarship of British Columbia, Province of British Columbia, Canada |
Selected Publications
Peer-Reviewed Articles
- Santo B, Fink EE, Krylova AE, Lin YC, Eltemamy M, Wee A, Wessely O, Lee BH, Ting AH. Exploring the utility of snRNA-seq in profiling human bladder tissue: A comprehensive comparison with scRNA-seq. iScience 28(1):111628, 2025. e-Pub 2025. PMID: 39850354.
- Fink EE, Nanavaty V, Lee BH, Ting AH. Heat shock induces alternative polyadenylation through dynamic DNA methylation-regulated chromatin looping. bioRxiv, 2023. e-Pub 2023. PMID: 37662379.
- Qiu H, Makarov V, Bolzenius JK, Halstead A, Parker Y, Wang A, Iyer GV, Wise H, Kim D, Thayaparan V, Lindner DJ, Haber GP, Ting AH, Ren B, Chan TA, Arora V, Solit DB, Lee BH. KDM6A loss triggers an epigenetic switch that disrupts urothelial differentiation and drives cell proliferation in bladder cancer. Cancer Res 83(6):814-829, 2023. e-Pub 2023. PMID: 36638328.
- Sona S, Bradley M, Ting AH. Protocols for single-cell RNA-seq and spatial gene expression integration and interactive visualization. STAR Protoc. e-Pub 2023.
- Fink EE, Sona S, Lee BH, Ting AH. Processing and cryopreservation of human ureter tissues for single-cell and spatial transcriptomics assays. STAR Protoc 3(4):101854, 2022. e-Pub 2022. PMID: 36595885.
- Fink EE, Sona S, Tran U, Desprez PE, Bradley M, Qiu H, Eltemamy M, Wee A, Wolkov M, Nicolas M, Min B, Haber GP, Wessely O, Lee BH, Ting AH. Single-cell and spatial mapping Identify cell types and signaling Networks in the human ureter. Dev Cell 57(15):1899-1916.e6, 2022. e-Pub 2022. PMID: 35914526.
- Nanavaty V, Abrash EW, Hong C, Park S, Fink EE, Li Z, Sweet TJ, Bhasin JM, Singuri S, Lee BH, Hwang TH, Ting AH. DNA Methylation Regulates Alternative Polyadenylation via CTCF and the Cohesin Complex. Mol Cell 78(4):752-764.e6, 2020. e-Pub 2020. PMID: 32333838.
- Liang J, Zhou W, Sakre N, DeVecchio J, Ferrandon S, Ting AH, Bao S, Bissett I, Church J, Kalady MF. Epigenetically regulated miR-1247 functions as a novel tumour suppressor via MYCBP2 in methylator colon cancers. Br J Cancer 119(10):1267-1277, 2018. e-Pub 2018. PMID: 30318507.
- Sarvestani SK, Signs SA, Lefebvre V, Mack S, Ni Y, Morton A, Chan ER, Li X, Fox P, Ting AH, Kalady MF, Cruise M, Ashburn J, Stiene J, Lai W, Liska D, Xiang S, Huang EH. Cancer-predicting transcriptomic and epigenetic signatures revealed for ulcerative colitis in patient-derived epithelial organoids. Oncotarget 9(47):28717-28730, 2018. e-Pub 2018. PMID: 29983891.
- Do J, Kim D, Kim S, Valentin-Torres A, Dvorina N, Jang E, Nagarajavel V, DeSilva TM, Li X, Ting AH, Vignali DAA, Stohlman SA, Baldwin WM, Min B. Treg-specific IL-27Rα deletion uncovers a key role for IL-27 in Treg function to control autoimmunity. Proc Natl Acad Sci U S A 114(38):10190-10195, 2017. e-Pub 2017. PMID: 28874534.
- Bhasin JM, Ting AH. Goldmine integrates information placing genomic ranges into meaningful biological contexts. Nucleic Acids Res 44(12):5550-6, 2016. e-Pub 2016. PMID: 27257071.
- Yan H, Tang G, Wang H, Hao L, He T, Sun X, Ting AH, Deng A, Sun S. DNA methylation reactivates GAD1 expression in cancer by preventing CTCF-mediated polycomb repressive complex 2 recruitment. Oncogene 35(30):3995-4008, 2016. e-Pub 2016. PMID: 26549033.
- Bhasin JM, Hu B, Ting AH. MethylAction: detecting differentially methylated regions that distinguish biological subtypes. Nucleic Acids Res 44(1):106-16, 2016. e-Pub 2016. PMID: 26673711.
- Sadler T, Bhasin JM, Xu Y, Barnholz-Sloan J, Chen Y, Ting AH, Stylianou E. Genome-wide analysis of DNA methylation and gene expression defines molecular characteristics of Crohn's disease-associated fibrosis. Clin Epigenetics 8:30, 2016. e-Pub 2016. PMID: 26973718.
- Bhasin JM, Lee BH, Matkin L, Taylor MG, Hu B, Xu Y, Magi-Galluzzi C, Klein EA, Ting AH. Methylome-wide Sequencing Detects DNA Hypermethylation Distinguishing Indolent from Aggressive Prostate Cancer. Cell Rep 13(10):2135-46, 2015. e-Pub 2015. PMID: 26628371.
- Al-Harbi S, Choudhary GS, Ebron JS, Hill BT, Vivekanathan N, Ting AH, Radivoyevitch T, Smith MR, Shukla GC, Almasan A. miR-377-dependent BCL-xL regulation drives chemotherapeutic resistance in B-cell lymphoid malignancies. Mol Cancer 14:185, 2015. e-Pub 2015. PMID: 26537004.
- Hu K, Ting AH, Li J. BSPAT: a fast online tool for DNA methylation co-occurrence pattern analysis based on high-throughput bisulfite sequencing data. BMC Bioinformatics 16:220, 2015. e-Pub 2015. PMID: 26163275.
Invited Articles
- Ting AH, Lee BH. 5mC: what goes on must come off. Nat Rev Mol Cell Biol 23(5):306, 2022. e-Pub 2022. PMID: 35217851.
- Sweet TJ, Ting AH. WOMEN IN CANCER THEMATIC REVIEW: Diverse functions of DNA methylation: implications for prostate cancer and beyond. Endocr Relat Cancer 23(11):T169-T178, 2016. e-Pub 2016. PMID: 27605446.
- Ting AH. WOMEN IN CANCER PROFILE: Dude, where's my band?. Endocr Relat Cancer 23(11):P33-P35, 2016. e-Pub 2016. PMID: 27605445.
Grant & Contract Support
| Date: | 2024 - 2029 |
| Title: | Interrogating the Role of Bacterial Methyl-modifying Enzymes in Pathoadaptation and Host Epigenetic Interference in Cancer |
| Funding Source: | NIH |
| Role: | Co-PI |
| ID: | R01CA290034 |
| Date: | 2024 - 2025 |
| Title: | The University of Texas MD Anderson Cancer Center Rising STARs Award |
| Funding Source: | The University of Texas System's PUF Bond |
| Role: | PI |
| ID: | N/A |
| Date: | 2023 - 2027 |
| Title: | 53BP1 regulates genome biology and cellular physiology through liquid phase separation |
| Funding Source: | NIH/NIGMS (S/C Case Western Reserve University) |
| Role: | Co-I |
| ID: | R01GM148662 |
| Date: | 2023 - 2028 |
| Title: | Activity and connectivity of hippocampal newborn neurons underlie alcohol withdrawal-associated syndromes |
| Funding Source: | NIH/NIAAA |
| Role: | Co-I |
| ID: | R01AA031028 |
| Date: | 2021 - 2026 |
| Title: | To establish correlation between maternal and newborn chromosome architecture |
| Funding Source: | Government of India, Ministry of Science & Technology |
| Role: | Formal Mentor |
| ID: | Ramalingaswami Re-entry Fellowship |
| Date: | 2021 - 2026 |
| Title: | High resolution transcriptome and gene regulatory mapping of human ureter and bladder across the lifespan |
| Funding Source: | NIH/NIDDK |
| Role: | Co-PI |
| ID: | U01 DK131383 |
Patient Reviews
CV information above last modified March 19, 2025