Ann M. Gillenwater, MD
Department of Head and Neck Surgery, Division of Surgery
About Dr. Ann M. Gillenwater
Dr. Ann Gillenwater is a Professor for the Department of Head and Neck Surgery, UT MD Anderson Cancer Center, Houston, Texas. She earned a BA in Russian studies from Brown University in 1979 and received her MD from the University of Virginia in 1983. She completed residency in Otolaryngology – Head and Neck Surgery at the University of Texas Health Science Center in Houston followed by a 2-year fellowship in Head and Neck Surgical Oncology at the University of Texas MD Anderson Cancer Center. She has been a faculty member since there 1994. She currently directs the Oral Cancer Prevention Clinic at UTMDACC.
Dr. Gillenwater’s clinical interests include oral precancers and cancers, thyroid neoplasms, salivary neoplasms, and non-melanoma skin cancer. Her research interests include detection and diagnosis of oral cancer and precancer, molecular imaging, and chemoprevention. A NIH-funded investigator, her research involves development of novel technologies for detection and diagnosis of oral cancer and precancer.
Dr. Gillenwater has published over 90 articles in peer-reviewed journals and is a reviewer for multiple journals.
Present Title & Affiliation
Primary Appointment
Professor (Adjunct Appointment), Division of Surgery, Rice University, Houston, TX
Professor, Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Director, Oral Cancer Prevention Center, Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas
Research Interests
Detection and treatment of early oral cancer and precancer
Merkel Cell Carcinoma
Developing optical imaging for oral cancer detection
Education & Training
Degree-Granting Education
| 1987 | University of Virginia, Charlottesville, Virginia, US, Medicine, MD |
| 1983 | Brown University, Providence, Rhode Island, US, Russian Studies, BA |
Postgraduate Training
| 1993-1994 | Clinical Fellowship, Dept. of Head & Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas |
| 1992-1993 | Research Fellowship, Dept. of Head & Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas |
| 1989-1992 | Otolaryngology Resident, Dept. of Otolaryngology/Head & Neck Surgery, UT Health Science Center at Houston, Houston, Texas |
| 1987-1989 | Surgical Internship, Dept. of General Surgery, UT Health Science Center At Houston, Houston, Texas |
Licenses & Certifications
| 2023 | Mississippi State Board of Medical Licensure |
| 2023 | Georgia Composite Medical Board |
| 2023 | Oklahoma State Board of Medical Licensure |
| 2023 | Tennessee Board of Medical Examiners |
| 2023 | Washington State Department of Health |
| 2023 | Louisiana State Board of Medical Examiners |
| 2023 | Arizona Medical Board |
| 2021 | Florida Board of Medicine |
| 1993 | American Board of Otolaryngology |
| 1987 | Texas Medical Board |
Experience & Service
Faculty Academic Appointments
Professor, Department of Bioengineering, Rice University, Houston, TX, 2015 - 2018
Adjunct Associate Professor, Department of Bioengineering, Rice University, Houston, TX, 2007 - 2008
Associate Professor, Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 2002 - 2008
Assistant Professor, Department of Head and Neck Surgery, UT M.D. Anderson Cancer Center, Houston, TX, 1996 - 2002
Instructor, Department of Head and Neck Surgery, UT M.D. Anderson Cancer Center, Houston, TX, 1994 - 1995
Junior Faculty Associate, Department of Head and Neck Surgery, UT M.D. Anderson Cancer Center, Houston, TX, 1994 - 1994
Other Professional Positions
Member, NIDCR Special Emphasis Study Section Committee, NIDCR, 2023 - Present
Adjunct Professor, Baylor College of Medicine, Houston, TX, 2021 - 2022
Adjunct Professor, Rice University, Houston, TX, 2018 - 2021
Alliance PI, MDA/Rakuten Medical Strategic Alliance, JSC Voting Member, MDA/Rakuten, 2016 - Present
Adjunct Professor, Baylor College of Medicine, Houston, TX, 2011 - 2012
Adjunct Associate Professor, Baylor College of Medicine, Houston, TX, 2010 - 2011
Adjunct Professor, Rice University, Houston, TX, 2010 - 2013
Intramural Institutional Committee Activities
Member, Laser Safety Committee, The University of Texas MD Anderson Cancer Center, 2017 - Present
Associate Member, Institutional Review Board 2 (IRB), The University of Texas MD Anderson Cancer Center, 2011 - Present
Member, Search Committee, Chair, Dept. of Critical Care, The University of Texas MD Anderson Cancer Center, 2004 - 2004
Member, ACB Faculty Advisory Task Force, UT M.D. Anderson Cancer Center, 2003 - 2003
Member, Faculty Health Committee, UT M. D. Anderson Cancer Center, 2002 - 2002
Member, Proton Pump Inhibitor Task Force, The University of Texas MD Anderson Cancer Center, 2001 - 2001
Member, Pediatric Critical Care Task Force, The University of Texas MD Anderson Cancer Center, 2001 - 2001
Member, Education Council Committee, The University of Texas MD Anderson Cancer Center, 2001 - 2001
Chairman, Graduate Medical Education Committee, The University of Texas MD Anderson Cancer Center, 1999 - 2001
Vice Chairman, Graduate Medical Education Committee, The University of Texas MD Anderson Cancer Center, 1997 - 1998
Member, Case Management Executive Committee, The University of Texas MD Anderson Cancer Center, 1996 - 1997
Member, Women Faculty and Administrator Organization (WFAO) Steering Committee, The University of Texas MD Anderson Cancer Center, 1996 - 1998
Director, Head & Neck Surgery Core Curriculum Course, The University of Texas MD Anderson Cancer Center, 1996 - 2003
Representative, Quality Assurance Representative, The University of Texas MD Anderson Cancer Center, 1995 - 2001
Member, Utilization and Case Management Committee, The University of Texas MD Anderson Cancer Center, 1995 - 1997
Editorial Activities
Editorial Board, Oral Oncology, 2005 - Present
Honors & Awards
| 2025 | Ranked in top 10% nationally by Clinician and Group Consumer Assessment of Healthcare Providers and Systems survey, CGCAHPS |
| 2024 | Ranked in top 10% nationally by Clinician and Group Consumer Assessment of Healthcare Providers and Systems survey, CGCAHPS |
| 2023 | Top Doctor of Houston - Otolaryngology, Castle Connolly |
| 2023 | Ranked in top 1% nationally by Clinician and Group Consumer Assessment of Healthcare Providers and Systems survey, CGCAHPS |
| 2021 | Service Award, American Head and Neck Society, Cancer Prevention Service, American Head and Neck Society |
| 2018 | 2018 Top Performers, Clinician and Group Consumer Assessment of Healthcare Providers and Systems (CGCAHPS) |
| 2002 | Honor Award, American Academy of Otolaryngology-Head & Neck Surgery |
| 2001 | UT MD Anderson Educator of the Month Award, UT MD Anderson Cancer Center |
| 1996 | Triological Society Research Training Award |
| 1983 | Magna Cum Laude, Brown University |
| 1982 | Phi Beta Kappa, Brown University |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2022. Techniques for Diagnosing Oral Lesions and Oral Biopsy Techniques. Invited. Oral Oncology Symposium, A Virtual Live Streaming Symposium. Houston, TX, US.
- 2022. New Approaches to Diagnosis and Management of OPMD and Early Oral Cancer. Invited. 4th Annual Oral Pathology Symposium. Houston, TX, US.
- 2020. Optical Imaging Approaches for Characterization of Oral Neoplasia. Invited. Head and Neck Research Mini-Symposium. Houston, TX, US.
- 2018. Surgical Management. Invited. Contemporary Methods for Functional Success After Head and Neck Cancer: The MD Anderson Cancer Center Approach. Houston, TX, US.
- 2015. Oral Cancer Prevention. Invited. , Optimizing Function in Patients with Head and Neck Cancer: The MD Anderson Cancer Center Approach. Houston, TX, US.
- 2014. Innovation in Oral Cancer Diagnosis. Invited. Oral Oncology: Oncologic Dentistry & Maxillofacial Prosthetics Symposium. Houston, TX, US.
- 2012. Developing Optical Devices to Assist in Detection and Diagnosis of Oral Cancer. Invited. Southern Biomedical Engineering Conference. Houston, TX, US.
- 2011. Innovation in Oral Cancer Diagnosis. Invited. Houston, TX, US.
- 2010. Oral Premalignant Lesions: Diagnosis, Management, Prognosis. Invited. Current Concepts in Head and Neck Surgery. Houston, TX, US.
- 2006. Oral Premalignancy (Invited Speaker). Invited. Current Concepts in Head & Neck Surgery Conference. Houston, TX, US.
- 2006. Optical Imaging for Oral Cancer Diagnosis. Invited. Advances in Oncology Institutional Grand Rounds. Houston, TX, US.
- 2006. Innovation in Oral Cancer Diagnosis (Invited Speaker). Invited. Oncologic Dentistry & Maxillofacial Prosthetics Symposium, UT MD Anderson Cancer Center. Houston, TX, US.
- 2006. Patient Candidacy: Medical and Surgical Criteria (Invited Speaker). Invited. Innovations in Tracheoesophageal Voice Restoration Symposium. Houston, TX, US.
- 2004. Optical Imaging for Detection and Diagnosis of Oral Cancer (Invited Speaker). Invited. Advances in Imaging-Guided Diagnosis and Therapy, 12th Annual Radiation Workshop. Houston, TX, US.
- 2003. Review: Early Diagnosis and Chemoprevention of Oral Cancer (Invited Speaker). Invited. UTMB 2nd Annual McLaughlin Symposium in Infection and Immunity. Galveston, TX, US.
- 2002. Thyroid Carcinoma" and "Optical Imaging of Oral Neoplasias (Invited Speaker). Invited. Texas Association of Otolaryngology - Head and Neck Surgery Annual Scientific Session. Dallas, TX, US.
Regional Presentations
- 2025. Techniques for Diagnosing Oral Lesions and Oral Biopsy Techniques. Invited. Oral Oncology Symposium. Houston, TX, US.
- 2020. Slide-free histology using a deep-learning-enabled microscope with extended depth-of-field. Poster. A 20-20 Vision of Biomedical Engineering, 2020 BMEs Virtual Annual Meeting, US.
- 2017. Imaging Technology and Detection of Oral Neoplasia. Invited. Workshop: Advancement of Head and Neck Cancer Detection Research. San Diego, CA, US.
- 2016. Oral Pre-Malignancy. Invited. Current Concepts in Head and Neck Surgery. Houston, TX, US.
- 2015. Functional Outcomes after Thyroid Surgery. Invited. 6th Current Concepts in the Management of Thyroid and Parathyroid Neoplasms Conference. Houston, TX, US.
- 2012. Squamous Cell Carcinoma in Fanconi Anemia Patients. Invited. Scientific Advisory Board of the Fanconi Research Fund. Chicago, IL, US.
- 2011. Optical Diagnostics versus Histopathology. Invited. SPIE Photonics West. San Francisco, CA, US.
- 2010. Carcinogenesis: Tissue Tropism and the Role of HPV. Invited. Fanconi Anemia Research Fund. Chicago, IL, US.
- 2009. Optical Imaging Approaches to Early Detection of Oral Cancer. Invited. Fanconi Anemia Research Scientific Symposium. Baltimore, MD, US.
- 2007. Fluorescence Spectroscopy and Imaging for Non-invasive Oral Cancer Diagnosis. Invited. 15th Annual SPORE Investigators' Workshop. Baltimore, MD, US.
- 2006. Medullary Thyroid Carcinoma. Invited. Head and Neck Endocrine Surgery Course. San Francisco, CA, US.
- 2005. Atypical Carcinoid Tumors of the Larynx. Invited. The Triological Society-Western Section Meeting. Las Vegas, NV, US.
- 2003. Diagnosis of Oral Cancer: What's New. Visiting. Emory University School of Medicine. Atlanta, GA, US.
- 1998. Oral Cancer: Latest Approach to Detection, Treatment, Rehabilitation and Prevention. Invited. American Speech-Language Hearing Association. San Antonio, TX, US.
- 1998. Education of Residents About Death and Dying. Invited. Society of University Otolaryngologists-Head & Neck Surgeons. Santa Fe, NM, US.
National Presentations
- 2024. A Multiscale Optical Imaging Approach to Real-Time Surgical Margin Assessment in Oral Cancer Surgery. Conference. AHNS 2024 COSM Meeting. Chicago, IL, US.
- 2021. Optical Imaging to Optimize Biopsy Site Location. Conference. Virtual AHNS 10th International Conference on Head and Neck Cancer “Survivorship through Quality and Innovation", US.
- 2021. Proof of concept for treating cutaneous squamous cell carcinoma with RM-1929 photoimmunotherapy: case examples of lesions with cutaneous involvement from a phase 1/2a trial of patients with recurrent head and neck squamous cell carcinoma. Conference. American College of Mohs Surgery Conference. Seattle, WA, US.
- 2020. Optical Technologies for Characterization of Oral Neoplasia. Invited. Multidisciplinary Head and Neck Cancers Symposium. Scottsdale, AZ, US.
- 2020. Survival Following Photoimmunotherapy in Patients with Recurrent Head and Neck Squamous Cell Carcinoma (HNSCC). Invited. Multidisciplinary Head and Neck Cancers Symposium. Scottsdale, AZ, US.
- 2019. Oral Pre-Malignancy. Invited. Current Concepts in Head and Neck Surgery. Houston, TX, US.
- 2018. Best Practice for Total Laryngectomy and Rehabilitation. Conference. AAO-HNSF Annual Meeting. Atlanta, GA, US.
- 2018. RM-1929 photo-immunotherapy in patients with recurrent head and neck cancer; promising results of a multi-center phase 2a open-label clinical trial. Invited. ASCO. Chicago, IL, US.
- 2016. Management of Pre-Malignant Lesions of the Head and Neck. Invited. 9th International Conference on Head and Neck Cancer. Seattle, WA, US.
- 2012. Oral Pre-malignancy. Invited. Current Concepts in Head and Neck Surgery. Houston, TX, US.
- 2012. Detection of Oral Cancer Using Light Technology. Invited. The American Academy of Oral Medicine. Charleston, SC, US.
- 2010. Oral Premalignant Lesions: Diagnosis, Management, Prognosis. Invited. Current Concepts in Head & Neck Surgery Conference. Houston, TX, US.
- 2007. Surgical Management of Cancer of the Oral Cavity. Invited. Current Concepts in Head & Neck Surgery. New York, NY, US.
- 2007. Management of Medullary Thyroid Carcinoma. Invited. Current Concepts in Head & Neck Surgery. New York, NY, US.
- 2006. Dual reflectance and fluorescence confocal microscope for near real-time morphological and molecular imaging of tissue. Poster. Society for Molecular Imaging Annual Meeting. Waikoloa, HI, US.
- 2006. Rhabdomyosarcoma of the Larynx in Adults. Poster. AHNS Annual Meeting & Research Workshop on the Biology Prevention and Treatment of Head & Neck Cancer. Chicago, IL, US.
- 2005. Genetics, Screening, and Evaluation & Treatment of Medullary Thyroid Cancer. Invited. Current Concepts in the Management of Thyroid and Parathyroid Neoplasms. Santa Fe, NM, US.
- 2002. SAHA Induces Growth Inhibition, Apoptosis and Differential Gene Expression in Head and Neck Squamous Carcinoma Cell Lines. Poster. American Association for Cancer Research Annual Meeting. San Francisco, CA, US.
- 2001. Fluorescence Spectroscopy and Imaging for Detection of Oral Neoplasia. Invited. American Academy of Maxillofacial Prosthetics Annual Meeting. New Orleans, LA, US.
- 2001. Optical Spectroscopy for the Non-Invasive Analysis of Oral Neoplasia. Poster. Ninth SPORE Investigator's Workshop. Washington, DC, US.
- 2000. Panel on Advanced Laryngeal Cancer. Invited. Fifth International Conference on Head & Neck Cancer. San Francisco, CA, US.
- 2000. An Alternative Approach to Larynx Preservation in Advanced Laryngeal Cancer using Chemotherapy and Surgery: Preliminary Results. Invited. 5th International Conference on Head & Neck Cancer. San Francisco, CA, US.
- 2000. Differential Effects of Butyroids, Retinoids and Their Combination on the Growth and Apoptosis of Human Cutaneous Squamous Cell Carcinoma (SCC) Cell Lines. Invited. American Association for Cancer Research Annual Meeting. San Francisco, CA, US.
- 1999. Optical Detection of Oral Neoplasia. Poster. American Head and Neck Society. Palm Desert, CA, US.
- 1999. Combination of Butyric Acid and Retinoic Acid Induces Growth Inhibition and Apoptosis in Non-Small Cell Lung Carcinoma Cell Lines. Invited. American Association for Cancer Research Annual Meeting. Philadelphia, PA, US.
- 1998. Prevention and Early Detection. Invited. American Academy of Otolaryngology-Head & Neck Surgery Annual Meeting. San Antonio, TX, US.
- 1998. Alternative Oncologic Surgical Approaches Preserving Function. Invited. American Academy of Otolaryngology-Head & Neck Surgery Annual Meeting. San Antonio, TX, US.
- 1998. Oral Tongue Cancer: Evaluation and Management. Invited. American Academy of Otolaryngology-Head & Neck Surgery Annual Meeting. San Antonio, TX, US.
- 1998. Combination of Retinoids with Butyrate Inhibits Growth and Induces Apoptosis in Head and Neck Squamous Cell Carcinoma Cell Lines. Invited. 1998 Joint ASHNS/SHNS Meeting Program. Palm Beach, FL, US.
International Presentations
- 2023. Safety and efficacy findings from a phase 1b/2 open-label study of a novel combination of ASP-1929 photoimmunotherapy with anti-PD-1 therapy in EGFR-expressing advanced head and neck squamous cell carcinoma (HNSCC). Conference. AHNS 11th International Conference on Head and Neck Cancer. Montreal, CA.
- 2022. Photodynamic Therapy and Photodiagnosis Update. Invited. PDT-PDD 2022 Symposium. Nancy, FR.
- 2020. Optical imaging technology to guide biopsy of oral mucosal lesions. Invited. Global Academic Programs (GAP) Virtual Conference 2020. Melbourne, AU.
- 2020. Photoimmunotherapy: A New Approach to Loco-regionally Recurrent H&N Cancer. Invited. Photodynamic Therapy and Photodiagnosis Update E-Congress 2020 (PDT & PD Update). Nancy, FR.
- 2019. Photoimmunotherapy: A new approach for management of recurrent locoregional H&N Cancer. Invited. The University of Tsukuba, Department of Otolaryngology. Tsukuba, Ibaraki, JP.
- 2018. Innovation in Oral Cancer Diagnosis. Invited. 2018 Eastern Shandong International Cancer Forum. Yantai, CN.
- 2018. Optical Imaging Technologies for Detection of Mucosal Neoplasia. Invited. 2018 Eastern Shandong International Cancer Forum. Yantai, CN.
- 2017. Early Detection and Chemoprevention. Invited. 6th World Oral Cancer Congress of the International Academy of Oral Oncology. Bangalore, IN.
- 2016. Diagnosis, Surveillance, and Management of Patients with Oral Premalignant Conditions. Invited. 25th Meeting of the Scandinavian Society for Head and Neck Oncology. Reykjavik, IS.
- 2015. Multidisciplinary Treatment for Tongue Cancer. Invited. Chilean Head and Neck Society. Pucon, CL.
- 2015. Advances in the Detection and Diagnosis of Cancer. Invited. Chilean Head and Neck Society. Pucon, CL.
- 2015. Malignant Tumors of the Salivary Glands. Invited. Chilean Head and Neck Society. Pucon, CL.
- 2015. Intraoral Premalignant Lesions. Invited. Chilean Head and Neck Society. Pucon, CL.
- 2014. Optical Imaging Technologies for Detection of Mucosal Neoplasia. Invited. World Congress Joint Meeting of the World Association for Bronchology and Interventional Pulmonology & The International Bronchoesophagology Society. Kyoto, JP.
- 2013. Observation of Patients with Oral Potentially Malignant Disorders Using Autofluorescence Imaging and Spectroscopy. Invited. AAO-HNSF Annual Meeting. Vancouver, CA.
- 2013. Best practice in management of head and neck cancer. Invited. Khon Kaen University, Otorhinolaryngology. Khon Kaen, TH.
- 2013. Early detection and screening of head and neck cancer. Invited. Khon Kaen University, Otorhinolaryngology. Khon Kaen, TH.
- 2013. Assessment and measurement of functional outcomes after treatment for head and neck cancer. Invited. National Taipei University of Nursing and Health Sciences. Taipei, TW.
- 2013. Speech and swallowing function in patients with head and neck cancer. Invited. National Taipei University of Nursing and Health Sciences. Taipei, TW.
- 2013. Optical Imaging Systems for Oral Cancer Detection and Diagnosis: A Global perspective. Invited. Head and Neck Optical Diagnostics Society. Munich, DE.
- 2012. Multimodal Optical Assessment of Oral Neoplasia. Invited. International Conference on Fluorescence based diagnostic of Oral Diseases. Montpellier, FR.
- 2012. Applications of Autofluorescence Imaging and Spectroscopy for Oral Cancer Surveillance. Invited. IADR General Session. Iguacu Falls, BR.
- 2011. Transitioning Engineering Developments into Clinical Practice: Optical Detection of Oral Cancer. Invited. IEEE Computer Society Asia University. Taichung, TW.
- 2011. Head and Neck and Lung Cancers. Invited. NCI Division of Cancer Prevention/Indian Council for Medical Research. Bangalore, IN.
- 2009. Advances in Oral Cancer Screening. Invited. Taiwan Otolaryngological Society. Taichung, TW.
- 2009. Autofluorescence Imaging for Early Detection of Oral Neoplasia. Conference. Second World Congress of the International Academic of Oral Oncology. Toronto, CA.
- 2009. Translational Optical Imaging. Invited. Head & Neck Optical Diagnostics Society. London, GB.
- 2008. Oral Cancer Screening using Optical Technology. Invited. All India Institute of Medical Sciences. New Delhi, IN.
- 2008. Optical Imaging and Spectroscopy for Detection and Diagnosis of Oral Neoplasia. Invited. Joint Meeting of the 3rd Symposium on Oral Health Science & 3rd Symposium on Dental and Craniofacial Morphogenesis and Tissue Regeneration. Fukuoka, JP.
- 2007. Optical Technologies for Oral Cancer Detection. Invited. University of Sao Paulo. Sao Paulo, BR.
- 2006. Innovations in Oral Cancer Diagnosis. Invited. Current Indications for Photodynamic Therapy. Amsterdam, NL.
- 2006. Optimizing Function Following Total Laryngectomy: a Surgeon's Perspective. Invited. Multidisciplinary Issues in the Management of Head & Neck Cancer. Sheffield, GB.
- 2006. Early Detection of Oral Neoplasia using Optical Imaging Technology. Invited. Multidisciplinary Issues in the Management of Head & Neck Cancer. Sheffield, GB.
- 2005. Innovation in Early Detection of Oral Premalignant Lesions. Invited. Multimodality Head and Neck Cancer Care in the New Millennium. Mumbai, IN.
- 2004. Diagnosis of Oral Precancer and Cancer. Invited. Dublin Dental Hospital. Dublin, IE.
- 2003. Detection and Diagnosis of Oral Neoplasia. Invited. All India Institute of Medical Sciences (AIIMS). New Dehli, IN.
- 2003. Detection and Diagnosis of Oral Neoplasia. Invited. Evidence-Based Management of Common Cancers. Mumbai, IN.
- 2001. Fluorescence Spectroscopy and Imaging for In Vivo Detection of Oral Cancer. Invited. Advances in Genes for Technology, Medicine, and Surgery Conference - A United Engineering Foundation Conference. Banff, CA.
Grant & Contract Support
| Date: | 2026 - 2031 |
| Title: | Neuroimmune Modulation of Oral Senescence: Exploring the Impact of Sensory Neuronal Signaling on Oral Carciongenesis |
| Funding Source: | NIH |
| Role: | Other Supporting Contributor |
| ID: | FP00027840 |
| Date: | 2026 - 2031 |
| Title: | MD Anderson Head and Neck Cancer SPORE: Oral Cavity (spORAL) |
| Funding Source: | NIH |
| Role: | Co-I |
| ID: | FP00024570 |
| Date: | 2024 - 2029 |
| Title: | AccessPath: A Low-Cost, Rugged, End-to-End System for Slide-Free Pathology Based on Computational Microscopy and Pan-Cancer Targeted Vital Dyes |
| Funding Source: | ARPA-H PSI |
| Role: | Co-I |
| ID: | D24AC00296 |
| Date: | 2023 - 2028 |
| Title: | The Center for Innovation and Translation of Point of Care Technologies for Equitable Cancer Care |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | U54EB034652-01 |
| Date: | 2022 - 2027 |
| Title: | Houston Oral Premalignancy Center of Excellence (HOPE) Core C: Pathology and Clinical Coordination Core |
| Funding Source: | NIH/NCI |
| Role: | Co-Core Leader |
| ID: | FP00014898 |
| Date: | 2022 - 2027 |
| Title: | Deep Learning Microscope for Slide-free and Digital Histology |
| Funding Source: | NIH/NCI |
| Role: | Co-PI |
| ID: | 1R01DE032051-01 |
| Date: | 2022 - 2027 |
| Title: | Genomic and Immune Targeting of Oral Leukoplakia to Prevent Progression to Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | PA-20-185 |
| Date: | 2022 - 2026 |
| Title: | Multimodal Optical Imaging to Improve Real-Time Margin Assessment During Oral Cancer Surgery |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Principal Investigator-MDACC |
| ID: | FP00013806 |
| Date: | 2022 - 2025 |
| Title: | Spatiotemporal Genomics and Network Analysis of Oncogenic Yap in Oral Cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Collaborator |
| ID: | RP220304 |
| Date: | 2021 - 2026 |
| Title: | Developing a Clinical Trial Platform for Local Delivery of Immunotherapy |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-I |
| ID: | RP210176 |
| Date: | 2021 - 2026 |
| Title: | Deep Learning Image Analysis Algorithms to Improve Oral Cancer Risk Assessment for Oral Potentially Malignant Disorders |
| Funding Source: | NIH/NIDCR |
| Role: | Co-I |
| ID: | R01-DE030656 |
| Date: | 2021 - 2024 |
| Title: | Mobile Imaging for Oral Cancer Screening Programs in Rural US Settings |
| Funding Source: | NIH/NIDCR |
| Role: | Principal Investigator-MDACC |
| ID: | R21 DE030532 |
| Date: | 2020 - 2024 |
| Title: | An Open-label Study using ASP-1929 Photoimmunotherapy in Combination with anti-PD1 Therapy in EGFR Expressing Advanced Solid Tumors |
| Funding Source: | Rakuten Medical, Inc |
| Role: | PI |
| ID: | 2020-0650 |
| Date: | 2020 - 2025 |
| Title: | Precision Optical Guidance for Oral Biopsy Based on Next-Generation Hallmarks of Cancer |
| Funding Source: | NIH/NIDCR |
| Role: | Co-PI |
| ID: | R01-DE029590 |
| Date: | 2019 - 2024 |
| Title: | A phase 3, Randomized, Double-Arm, Open-Label, Controlled Trial of ASP-1929 Photoimmunotherapy Versus Physician's Choice Standard of Care for the Treatment of Locoregional, Recurrent Head and Neck Squamous Cell Carcinoma in Patients Who Have Failed or Progressed on or After Two Lines of Therapy |
| Funding Source: | Rakuten Medical, Inc |
| Role: | PI |
| ID: | 2018-1086 |
| Date: | 2019 - 2025 |
| Title: | Randomized Phase II/III Trial of Sentinel Lymph Node Biopsy Versus Elective Neck Dissection for Early-Stage Oral Cavity Cancer |
| Funding Source: | NRG Oncology |
| Role: | Collaborator |
| ID: | 2020-0277 |
| Date: | 2016 - 2019 |
| Title: | Phase I Multicenter, Open-Label, Dose-Escalation, Combination Study of RM-1929 and Photoimmunotherapy in Patients with Recurrent Head and Neck Cancer |
| Funding Source: | Aspyrian Therapeutics, Inc |
| Role: | PI |
| ID: | 2015-0950 |
| Date: | 2015 - 2016 |
| Title: | Optical and Molecular Biomarkers for Oral Cancer Detection |
| Funding Source: | Red & Charline McCombs Institute |
| Role: | PI |
| Date: | 2014 - 2018 |
| Title: | Optical Hallmarks of Aggressive Clones within Oral Field Cancerization |
| Funding Source: | NIH/NCI |
| Role: | Subcomponent Principal Investigator |
| ID: | R01-CA185207-03 |
| Date: | 2014 - 2015 |
| Title: | High Resolution and Wide-field Fluorescence Imaging to Detect Oral Neoplasia |
| Funding Source: | MD Anderson Cancer Center |
| Role: | PI |
| ID: | HI-CRSP |
| Date: | 2014 - 2018 |
| Title: | Molecular Genetics of Field Cancerization in Oral Squamous Cell Carcinoma |
| Funding Source: | NIH/NCI |
| Role: | Co-PI |
| Date: | 2014 - 2019 |
| Title: | Rapid Non-invasive Detection of Microscopic Tumors |
| Funding Source: | NIH/NCI |
| Role: | Co-PI |
| Date: | 2013 - 2015 |
| Title: | Mild Dysplasia in the Oral Cavity: Optical Measurements vs. Biomarker Expression |
| Funding Source: | NIH/NCI |
| Role: | Subcomponent Principal Investigator |
| Date: | 2013 - 2018 |
| Title: | Integrative Genomic Modeling for Oral Cancer Progression |
| Funding Source: | NIH/NCI |
| Role: | Co-PI |
| Date: | 2013 - 2013 |
| Title: | Surveillance of Dysplastic Oral Lesions Using Novel Lab-On-A-Chip Ensembles |
| Funding Source: | NIH/NCI |
| Role: | Co-PI |
| Date: | 2012 - 2015 |
| Title: | Miniature Foveated Endoscope for Early Cancer Diagnostics |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | R21EB015022 |
| Date: | 2012 - 2014 |
| Title: | miR-17-92 in Salivary Gland Tumors |
| Funding Source: | NIH/NCI |
| Role: | Co-PI |
| Date: | 2012 - 2017 |
| Title: | Acoustic Imaging of Sentinel Node Metastasis using Plasmonic Nanosensors |
| Funding Source: | NIH/NIBIB |
| Role: | Co-I |
| ID: | R01 EB008101-08 |
| Date: | 2012 - 2014 |
| Title: | Multimodal Optical System for Intra-operative Assessment of Tumor Margins |
| Funding Source: | NIH/NCI |
| Role: | Co-PI |
| ID: | MDACC 11101075 |
| Date: | 2011 - 2017 |
| Title: | Optical Systems for In Vivo Molecular Imaging of Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | R01 CA103830-10 |
| Date: | 2011 - 2016 |
| Title: | Competitive Renewal: Optical Systems for In Vivo Molecular Imaging of Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-PI |
| ID: | R01 CA103830 |
| Date: | 2010 - 2014 |
| Title: | Multi-modal optical imaging system for early detection of oral cancer |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-PI |
| ID: | RP 100932 |
| Date: | 2009 - 2014 |
| Title: | Adherence to Swallowing Rehabilitation Exercises in Head and Neck Cancer |
| Funding Source: | NIH/NIDCR |
| Role: | Significant Contributor |
| ID: | 1R01-DE019141 |
| Date: | 2009 - 2015 |
| Title: | Fluorescence Spectrosocpy to Detect Oral Neoplasia |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | R01 CA095604 |
| Date: | 2009 - 2014 |
| Title: | Oral Cancer Detection Using Targeted Optical Agents |
| Funding Source: | NIH/NIDCR |
| Role: | PI |
| ID: | R01DE019220-01A1 |
| Date: | 2008 - 2010 |
| Title: | Moleculary Targeted Nanoparticles for Proteomic Biomarker Identification of Exfoliated Oral Cavity Cells |
| Funding Source: | NIH/NCI |
| Role: | Awardee |
| ID: | P50 CA097007 |
| Date: | 2008 - 2013 |
| Title: | UTMDACC Head & Neck SPORE Developmental Research Program Award |
| Funding Source: | NIH/NCI |
| Role: | Significant Contributor |
| ID: | P50CA097007 |
| Date: | 2008 - 2013 |
| Title: | Oral Cancer Detection Using Targeted Optical Agents |
| Funding Source: | NIH/NIDCR |
| Role: | PI |
| ID: | R01DE019220-01 |
| Date: | 2008 - 2013 |
| Title: | Molecular Epidemiology of DNA Repair in Head and Neck Cancer |
| Funding Source: | NIH/NIEHS |
| Role: | Consult |
| ID: | R01 ES111740 |
| Date: | 2007 - 2012 |
| Title: | Integrated Bi-FOV Endoscope for Detection of Precancer |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | R01-CA124319 |
| Date: | 2007 - 2010 |
| Title: | Oral Cancer Screening in India using Optical Imaging Technology |
| Funding Source: | NIH/NIDCR |
| Role: | PI |
| ID: | R03-TW007910 |
| Date: | 2006 - 2008 |
| Title: | Early Cancer Detection with Two-Photon Luminescence from Gold Nanorods |
| Funding Source: | NIH/NINDS |
| Role: | Co-I |
| ID: | R03 CA125774 |
| Date: | 2006 - 2011 |
| Title: | Institutional National Research Science Award |
| Funding Source: | NIH/NCI |
| Role: | Mentor |
| ID: | T32 CA60374 |
| Date: | 2006 - 2006 |
| Title: | High Resolution Two-Photon Microscopy for the Characterization of Oral Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2005 - 2011 |
| Title: | Polarization Spectroscopy and Imaging of Pre-Cancer |
| Funding Source: | NIH |
| Role: | Co-I |
| ID: | R01 EB003540 |
| Date: | 2004 - 2007 |
| Title: | Multispectral Imaging for Oral Cancer Detection |
| Funding Source: | NICDR |
| Role: | PI |
| ID: | R21 DE016485 |
| Date: | 2004 - 2006 |
| Title: | Depression and Adherence in Head and Neck Cancer |
| Funding Source: | NCI |
| Role: | Collaborator |
| ID: | R03 CA108358 |
| Date: | 2003 - 2014 |
| Title: | Phase IB Randomized, Double-Blind, Placebo-Controlled, Trial of Piolglitazone for Oral Leukoplakia |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | NO1 CN-035159 |
| Date: | 2003 - 2009 |
| Title: | Optical Systems for In Vivo Molecular Imaging of Cancer |
| Funding Source: | NIH/BRP |
| Role: | Co-I |
| ID: | R01 CA103829 |
| Date: | 2003 - 2009 |
| Title: | Fluorescence Spectroscopy to Detect Oral Neoplasia |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | R01 CA95604 |
| Date: | 2002 - 2008 |
| Title: | Fiber Optic In Vivo Confocal Microscopy |
| Funding Source: | NIH |
| Role: | Co-I |
| ID: | R01 EB002179 |
| Date: | 2001 - 2006 |
| Title: | Molecular Epidemiology of Head and Neck Cancer |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| ID: | R01-ES11740-1 |
Selected Publications
Peer-Reviewed Articles
- Trinconi Cunha M, Sewastjanow-Silva M, Holsinger FC, Garden AS, El-Naggar AK, Myers JN, Lewin J, Gillenwater AM, Lee JJ, Khuri FR, Diaz EM Jr, Ferrarotto R. Chemotherapy alone for stage II-IVa laryngeal squamous cell carcinoma: A 20-year follow-up. Cancer 131(23):e70177, 2025. e-Pub 2025. PMID: 41250807.
- Mitbander, R, Carns, J, Schwarz, RA, Anderson, S, Vipulanandan, G, Hernandez, M, Hartzell, AE, Jiao, J, Rutkowska, I, Durab, S, Sadeghi, S, Clayton, AD, Bass, NE, Anandasivam, L, Giese, RA, Gillenwater, AM, Vigneswaran, N, Richards-Kortum, R. Optimization of a mobile imaging system to aid in evaluating patients with oral lesions in a dental care setting. Biophotonics Discovery 2(4), 2025. e-Pub 2025.
- Mitbander R, Carns J, Schwarz RA, Anderson S, Vipulanandan G, Hernandez M, Hartzell AE, Jiao J, Rutkowska I, Durab S, Sadeghi S, Clayton AD, Bass N, Anandasivam L, Giese RA, Gillenwater AM, Vigneswaran N, Richards-Kortum R. Optimization of a mobile imaging system to aid in evaluating patients with oral lesions in a dental care setting. Biophotonics Discov 2(4):042307, 2025. e-Pub 2025.
- Cognetti DM, Curry JM, Johnson J, Kwon M, Su SY, Civantos F, Olazagasti C, Valentino J, Arnold SM, Bell RB, Gibson MK, Mannion K, Van Abel KM, Price KA, Dong H, Thorne AH, Suzuki T, Gillenwater AM. Safety and Efficacy Findings From a Phase Ib/II Study of ASP-1929 Photoimmunotherapy With Pembrolizumab in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma. Head Neck, 2025. e-Pub 2025. PMID: 40852760.
- Mitbander R, Brenes D, Coole JB, Kortum A, Vohra IS, Carns J, Schwarz RA, Varghese I, Durab S, Anderson S, Bass NE, Clayton AD, Badaoui H, Anandasivam L, Giese RA, Gillenwater AM, Vigneswaran N, Richards-Kortum R. Development and Evaluation of an Automated Multimodal Mobile Detection of Oral Cancer Imaging System to Aid in Risk-Based Management of Oral Mucosal Lesions. Cancer Prev Res (Phila) 18(4):197-207, 2025. e-Pub 2025. PMID: 39817650.
- Jin, L, Tang, Y, Coole, J, Tan, MT, Zhao, X, Badaoui, H, Robinson, JT, Williams, MD, Vigneswaran, N, Gillenwater, AM, Richards-Kortum, R, Veeraraghavan, A. DeepDOF-SE. Nature communications 15(1), 2024. e-Pub 2024. PMID: 38580633.
- John E, Lesluyes T, Baker TM, Tarabichi M, Gillenwater A, Wang JR, Van Loo P, Zhao X. Reconstructing oral cavity tumor evolution through brush biopsy. Sci Rep 14(1):22591, 2024. e-Pub 2024. PMID: 39343812.
- Hou, H, Carns, J, Schwarz, RA, Gillenwater, AM, Anandasabapathy, S, Richards-Kortum, R. Use of topical methylene blue to image nuclear morphometry with a low-cost scanning darkfield microendoscope. Journal of biomedical optics 29(5), 2024. e-Pub 2024. PMID: 38774711.
- Hou H, Tang Y, Coole JB, Kortum A, Schwarz RA, Carns J, Gillenwater AM, Ramalingam P, Milbourne A, Salcedo MP, Schmeler KM, Richards-Kortum RR. Scanning darkfield high-resolution microendoscope for label-free microvascular imaging. Biomed Opt Express 14(10):5097-5112, 2023. e-Pub 2023. PMID: 37854554.
- Mansour J, Nesbitt B, Khanjae S, Horowitz G, Amit M, Muhanna N, Hofstede TM, Gillenwater A. The Feasibility and Outcome of Integra® Bilayer Matrix in the Reconstruction of Oral Cavity Defects. Otolaryngol Head Neck Surg. e-Pub 2023. PMID: 37717219.
- Zhang X, Gleber-Netto FO, Wang S, Jin KW, Yang DM, Gillenwater AM, Myers JN, Ferrarotto R, Pickering CR, Xiao G. A Deep Learning Onion Peeling Approach to Measure Oral Epithelium Layer Number. Cancers (Basel) 15(15), 2023. e-Pub 2023. PMID: 37568707.
- Zhang X, Gleber-Netto FO, Wang S, Martins-Chaves RR, Gomez RS, Vigneswaran N, Sarkar A, William WN, Papadimitrakopoulou V, Williams M, Bell D, Palsgrove D, Bishop J, Heymach JV, Gillenwater AM, Myers JN, Ferrarotto R, Lippman SM, Pickering CR, Xiao G. Deep learning-based pathology image analysis predicts cancer progression risk in patients with oral leukoplakia. Cancer Med 12(6):7508-18. e-Pub 2023. PMID: 36721313.
- William WN, Zhang J, Zhao X, Parra ER, Uraoka N, Lin HY, Peng SA, El-Naggar AK, Rodriguez-Canales J, Song J, Gillenwater AM, Wistuba II, Myers JN, Gold KA, Ferrarotto R, Hwu P, Davoli T, Lee JJ, Heymach JV, Papadimitrakopoulou VA, Lippman SM. Spatial PD-L1, immune-cell microenvironment, and genomic copy-number alteration patterns and drivers of invasive-disease transition in prospective oral precancer cohort. Cancer. e-Pub 2023. PMID: 36597662.
- Coole, J, Brenes, D, Mitbander, R, Vohra, IS, Hou, H, Kortum, A, Tang, Y, Maker, Y, Schwarz, RA, Carns, J, Badaoui, H, Williams, MD, Vigneswaran, N, Gillenwater, AM, Richards-Kortum, R. Multimodal optical imaging with real-Time projection of cancer risk and biopsy guidance maps for early oral cancer diagnosis and treatment. Journal of biomedical optics 28(1), 2023. e-Pub 2023. PMID: 36654656.
- Bouvard, V, Nethan, ST, Singh, D, Warnakulasuriya, S, Mehrotra, R, Chaturvedi, A, Chen, TH, Ayo-Yusuf, O, Gupta, PC, Kerr, AR, Tilakaratne, WM, Anantharaman, D, Conway, DI, Gillenwater, AM, Johnson, NW, Kowalski, LP, Leon, ME, Mandrik, O, Nagao, T, Prasad, VM, Ramadas, K, Roitberg, F, Saintigny, P, Sankaranarayanan, R, Santos-Silva, AR, Sinha, DN, Vatanasapt, P, Zain, RB, Lauby-Secretan, B. IARC Perspective on Oral Cancer Prevention. New England Journal of Medicine 387(21):1999-2005, 2022. e-Pub 2022. PMID: 36378601.
- Brenes DR, Nipper AJ, Tan MT, Gleber-Netto FO, Schwarz RA, Pickering CR, Williams MD, Vigneswaran N, Gillenwater AM, Sikora AG, Richards-Kortum RR. Mildly dysplastic oral lesions with optically-detectable abnormalities share genetic similarities with severely dysplastic lesions. Oral Oncol 135:106232. e-Pub 2022. PMID: 36335817.
- Contrera KJ, Zafereo ME, Yaniv D, Roberts DB, Gillenwater AM, Hanna EY, Weber RS, Myers JN, Chang EI, Garvey PB, Hanasono MM, Yu P, Hutcheson KA, Fuller CD, Tyler MA, Neskey DM. Outcomes for recurrent oral cavity squamous cell carcinoma. Oral Oncol 134:106127, 2022. e-Pub 2022. PMID: 36155359.
- Wise-Draper TM, Gulati S, Palackdharry S, Hinrichs BH, Worden FP, Old MO, Dunlap NE, Kaczmar JM, Patil Y, Riaz MK, Tang A, Mark J, Zender C, Gillenwater AM, Bell D, Kurtzweil N, Mathews M, Allen CL, Mierzwa ML, Casper K, Jandarov R, Medvedovic M, Lee JJ, Harun N, Takiar V, Gillison M. Phase II Clinical Trial of Neoadjuvant and Adjuvant Pembrolizumab in Resectable Local-Regionally Advanced Head and Neck Squamous Cell Carcinoma. Clin Cancer Res 28(7):1345-1352, 2022. e-Pub 2022. PMID: 35338369.
- Contrera KJ, Chinn SB, Weber RS, Roberts D, Myers JN, Lai SY, Lewis CM, Hessel AC, Gillenwater AM, Mulcahy CF, Yu P, Hanasono MM, Fuller CD, Chambers MS, Zafereo ME. Outcomes after definitive surgery for mandibular osteoradionecrosis. Head Neck. e-Pub 2022. PMID: 35238096.
- Cognetti DM, Johnson JM, Curry JM, Kochuparambil ST, McDonald D, Mott F, Fidler MJ, Stenson K, Vasan NR, Razaq MA, Campana J, Ha P, Mann G, Ishida K, Garcia-Guzman M, Biel M, Gillenwater AM. Phase 1/2a, open-label, multicenter study of RM-1929 photoimmunotherapy in patients with locoregional, recurrent head and neck squamous cell carcinoma. Head Neck 43(12):3875-3887, 2021. e-Pub 2021. PMID: 34626024.
- Dahlstrom KR, Anderson KS, Guo M, Kwon MC, Messick CA, Pettaway CA, Asomaning N, Hopper M, Price A, Xu L, Day AT, Gillenwater AM, Sturgis EM. Screening for HPV-related oropharyngeal, anal, and penile cancers in middle-aged men: Initial report from the HOUSTON clinical trial. Oral Oncol 120:105397. e-Pub 2021. PMID: 34182223.
- Abdelmeguid AS, Silver NL, Boonsripitayanon M, Glisson BS, Ferrarotto R, Gunn GB, Phan J, Gillenwater AM, Hanna EY. Role of induction chemotherapy for oral cavity squamous cell carcinoma. Cancer. e-Pub 2021. PMID: 33909292.
- Sweeney KJ, Tetzlaff MT, Vega F, Gillenwater A, Zuo Z, Gross N, Nagarajan P, Wargo J, Nelson K, Prieto VG, Torres-Cabala CA, Curry JL. Tertiary lymphoid structures with overlapping histopathologic features of cutaneous marginal zone lymphoma during neoadjuvant cemiplimab therapy is associated with antitumor response. J Cutan Pathol. e-Pub 2021. PMID: 33399228.
- Tan MT, Wu JG, Callejas-Valera JL, Schwarz RA, Gillenwater AM, Richards-Kortum RR, Vigneswaran N. A PIK3CA transgenic mouse model with chemical carcinogen exposure mimics human oral tongue tumorigenesis. Int J Exp Pathol. e-Pub 2020. PMID: 32436348.
- Head A, Guidelines Consortium NST, Maniakas A, Jozaghi Y, Zafereo ME, Sturgis EM, Su SY, Gillenwater AM, Gidley PW, Lewis CM, Diaz E, Goepfert RP, Kupferman ME, Gross ND, Hessel AC, Pytynia KB, Nader ME, Wang JR, Lango MN, Kiong KL, Guo T, Zhao X, CMKL Y, Appelbaum E, Alpard J, Garcia JA, Terry S, Flynn JE, Bauer S, Fournier D, Burgess CG, Wideman C, Johnston M, You C, De Luna R, Joseph L, Diersing J, Prescott K, Heiberger K, Mugartegui L, Rodriguez J, Zendehdel S, Sellers J, Friddell RA, Thomas A, Khanjae SJ, Schwarzlose KB, Chambers MS, Hofstede TM, Cardoso RC, Aponte Wesson R, Won A, Otun AO, Gombos DS, Al-Zubidi N, Hutcheson KA, Gunn GB, Rosenthal DI, Gillison ML, Ferrarotto R, Weber RS, Hanna EY, Myers JN, Lai SY. Head and neck surgical oncology in the time of a pandemic: Subsite-specific triage guidelines during the COVID-19 pandemic. Head Neck. e-Pub 2020. PMID: 32342541.
- Yang EC, Vohra IS, Badaoui H, Schwarz RA, Cherry KD, Jacob J, Rodriguez J, Williams MD, Vigneswaran N, Gillenwater AM, Richards-Kortum RR. Prospective evaluation of oral premalignant lesions using a multimodal imaging system: a pilot study. Head Neck 42(2):171-179, 2020. e-Pub 2020. PMID: 31621979.
- Cherry KD, Schwarz RA, Yang EC, Vohra IS, Badaoui H, Williams MD, Vigneswaran N, Gillenwater AM, Richards-Kortum R. Autofluorescence Imaging to Monitor the Progression of Oral Potentially Malignant Disorders. Cancer Prev Res (Phila) 12(11):791-800, 2019. e-Pub 2019. PMID: 31451520.
- Yang EC, Vohra IS, Badaoui H, Schwarz RA, Cherry KD, Quang T, Jacob J, Lang A, Bass N, Rodriguez J, Williams MD, Vigneswaran N, Gillenwater AM, Richards-Kortum RR. Development of an integrated multimodal optical imaging system with real-time image analysis for the evaluation of oral premalignant lesions. J Biomed Opt 24(2):1-10, 2019. e-Pub 2019. PMID: 30793567.
- Yang EC, Schwarz RA, Lang AK, Bass N, Badaoui H, Vohra IS, Cherry KD, Williams MD, Gillenwater AM, Vigneswaran N, Richards-Kortum RR. In Vivo Multimodal Optical Imaging: Improved Detection of Oral Dysplasia in Low-Risk Oral Mucosal Lesions. Cancer Prev Res (Phila) 11(8):465-476, 2018. e-Pub 2018. PMID: 29903741.
- Mays AC, Gillenwater AM, Garvey PB. Rare presentation of heterotopic ossification along a fibula free flap pedicle in a high-volume microvascular reconstruction practice. Head Neck 40(3):E21-E24, 2018. e-Pub 2018. PMID: 29272061.
- Abram TJ, Pickering CR, Lang AK, Bass NE, Raja R, Meena C, Alousi AM, Myers JN, McDevitt JT, Gillenwater AM, Vigneswaran N. Risk Stratification of Oral Potentially Malignant Disorders in Fanconi Anemia Patients Using Autofluorescence Imaging and Cytology-On-A Chip Assay. Transl Oncol 11(2):477-486. e-Pub 2018. PMID: 29481998.
- Quang T, Tran EQ, Schwarz RA, Williams MD, Vigneswaran N, Gillenwater AM, Richards-Kortum R. Prospective Evaluation of Multi-modal Optical Imaging with Automated Image Analysis to Detect Oral Neoplasia In Vivo. Cancer Prev Res (Phila) 10(10):563-570, 2017. e-Pub 2017. PMID: 28765195.
- Quinlan-Davidson SR, Mohamed ASR, Myers JN, Gunn GB, Johnson FM, Skinner H, Beadle BM, Gillenwater AM, Phan J, Frank SJ, William WN, Wong AJ, Lai SY, Fuller CD, Morrison WH, Rosenthal DI, Garden AS. Outcomes of oral cavity cancer patients treated with surgery followed by postoperative intensity modulated radiation therapy. Oral Oncol 72:90-97, 2017. e-Pub 2017. PMID: 28797467.
- Quinlan-Davidson SR, Morrison WH, Myers JN, Gunn GB, William WN, Beadle BM, Skinner HD, Gillenwater AM, Frank SJ, Phan J, Johnson FM, Fuller CD, Zafereo ME, Rosenthal DI, Garden AS. Recurrent oral cavity cancer: Patterns of failure after salvage multimodality therapy. Head Neck 39(4):633-638, 2017. e-Pub 2017. PMID: 28006086.
- Kawedia JD, Zhang YP, Myers AL, Richards-Kortum RR, Kramer MA, Gillenwater AM, Culotta KS. Physical and chemical stability of proflavine contrast agent solutions for early detection of oral cancer. J Oncol Pharm Pract 22(1):21-5, 2016. e-Pub 2016. PMID: 25113309.
- Lukianova-Hleb EY, Kim YS, Belatsarkouski I, Gillenwater AM, O'Neill BE, Lapotko DO. Intraoperative diagnostics and elimination of residual microtumours with plasmonic nanobubbles. Nat Nanotechnol. e-Pub 2016. PMID: 26878142.
- William WN, Papadimitrakopoulou V, Lee JJ, Mao L, Cohen EE, Lin HY, Gillenwater AM, Martin JW, Lingen MW, Boyle JO, Shin DM, Vigneswaran N, Shinn N, Heymach JV, Wistuba II, Tang X, Kim ES, Saintigny P, Blair EA, Meiller T, Gutkind JS, Myers J, El-Naggar A, Lippman SM. Erlotinib and the Risk of Oral Cancer: The Erlotinib Prevention of Oral Cancer (EPOC) Randomized Clinical Trial. JAMA Oncol 2(2):1-8, 2016. e-Pub 2016. PMID: 26540028.
- Shinn EH, Valentine A, Jethanandani A, Basen-Engquist K, Fellman B, Urbauer D, Atkinson E, Yusuf SW, Lenihan D, Woods ML, Kies MS, Sood AK, Carmack C, Morrison WH, Gillenwater A, Sturgis EM, Garden AS. Depression and Oropharynx Cancer Outcome. Psychosom Med 78(1):38-48, 2016. e-Pub 2016. PMID: 26632757.
- Ishijima A, Schwarz RA, Shin D, Mondrik S, Vigneswaran N, Gillenwater AM, Anandasabapathy S, Richards-Kortum R. Automated frame selection process for high-resolution microendoscopy. J Biomed Opt 20(4):46014, 2015. e-Pub 2015. PMID: 25919426.
- Bishop AJ, Garden AS, Gunn GB, Rosenthal DI, Beadle BM, Fuller CD, Levy LB, Gillenwater AM, Kies MS, Esmaeli B, Frank SF, Phan J, Morrison WH. Merkel cell carcinoma of the head and neck: Favorable outcomes with radiotherapy. Head Neck. e-Pub 2015. PMID: 25645649.
- Floriano P, Abram T, Taylor L, Le C, Talavera H, Nguyen M, Raja R, Gillenwater A, McDevitt J, Vigneswaran N. Programmable Bio-Nano-Chip based Cytologic Testing of Oral Potentially Malignant Disorders in Fanconi Anemia. Oral Dis. e-Pub 2015. PMID: 25662766.
- Hellebust A, Rosbach K, Wu JK, Nguyen J, Gillenwater A, Vigneswaran N, Richards-Kortum R. Vital-dye-enhanced multimodal imaging of neoplastic progression in a mouse model of oral carcinogenesis. J Biomed Opt 18(12):126017, 2013. e-Pub 2013. PMID: 24362926.
- Gillenwater AM, Frank SJ, Fatani H, El-Naggar AK. Primary intestinal-like adenocarcinoma of major salivary glands: 2 instances of previously undocumented phenotype. Head Neck 35(8):E234-6, 2013. e-Pub 2013. PMID: 23108630.
- Bedard N, Schwarz RA, Hu A, Bhattar V, Howe J, Williams MD, Gillenwater AM, Richards-Kortum R, Tkaczyk TS. Multimodal Snapshot Spectral Imaging for Oral Cancer Diagnostics: a pilot study. Biomed Opt Express 4(6), 2013. e-Pub 2013. PMID: 23760882.
- Vila PM, Park CW, Pierce MC, Goldstein GH, Levy L, Gurudutt VV, Polydorides AD, Godbold JH, Teng MS, Genden EM, Miles BA, Anandasabapathy S, Gillenwater AM, Richards-Kortum R, Sikora AG. Discrimination of Benign and Neoplastic Mucosa with a High-Resolution Microendoscope (HRME) in Head and Neck Cancer. Ann Surg Oncol 19(11):3534-9, 2012. e-Pub 2012. PMID: 22492225.
- Rosbach KJ, Williams MD, Gillenwater AM, Richards-Kortum RR. Optical molecular imaging of multiple biomarkers of epithelial neoplasia: epidermal growth factor receptor expression and metabolic activity in oral mucosa. Transl Oncol 5(3):160-71, 2012. e-Pub 2012. PMID: 22741035.
- Pierce MC, Schwarz RA, Bhattar VS, Mondrik S, Williams MD, Lee JJ, Richards-Kortum R, Gillenwater AM. Accuracy of in vivo multimodal optical imaging for detection of oral neoplasia. Cancer Prev Res (Phila) 5(6):801-9, 2012. e-Pub 2012. PMID: 22551901.
- Muldoon TJ, Roblyer D, Williams MD, Stepanek VM, Richards-Kortum R, Gillenwater AM. Noninvasive imaging of oral neoplasia with a high-resolution fiber-optic microendoscope. Head Neck 34(3):305-12, 2012. e-Pub 2012. PMID: 21413101.
- Levy LL, Vila PM, Park RW, Schwarz R, Polydorides AD, Teng MS, Gurudutt VV, Genden EM, Miles B, Anandasabapathy S, Gillenwater AM, Richards-Kortum R, Sikora AG. High-Resolution Optical Imaging of Benign and Malignant Mucosa in the Upper Aerodigestive Tract: An Atlas for Image-Guided Surgery. ISRN Minim Invasive Surg 2012, 2012. e-Pub 2012. PMID: 23641314.
- Roblyer D, Kurachi C, Stepanek V, Schwarz RA, Williams MD, El-Naggar AK, Lee JJ, Gillenwater AM, Richards-Kortum R. Comparison of multispectral wide-field optical imaging modalities to maximize image contract for objective discrimination of oral neoplasia. J Biomed Opt 15(6):066017, 2010. e-Pub 2010. PMID: 21198191.
- Schwarz RA, Gao W, Stepanek VM, Le TT, Bhattar VS, Williams MD, Wu JK, Vigeneswaran N, Adler-Storthz K, Gillenwater AM, Richards-Kortum R. Prospective evaluation of a portable depth-sensitive optical spectroscopy device to identify oral neoplasia. Biomed Opt Express 2(1):89-99, 2010. e-Pub 2010. PMID: 21326639.
- Vadhan-Raj S, Trent J, Patel S, Zhou X, Johnson MM, Araujo D, Ludwig JA, O'Roark S, Gillenwater AM, Bueso-Ramos C, El-Naggar AK, Benjamin RS. Single-dose palifermin prevents severe oral mucositis during multicycle chemotherapy in patients with cancer: A randomized trial. Ann Intern Med 153(6):358-67, 2010. e-Pub 2010. PMID: 20855800.
- Shin D, Pierce MC, Gillenwater AM, Williams MD, Richards-Kortum R. A fiber-optic fluorescence microscope using a consumer-grade digital camera for in vivo cellular imaging. PLoS One 5(6):e11218, 2010. e-Pub 2010. PMID: 20585636.
- Rahman MS, Ingole N, Roblyer D, Stepanek V, Richards-Kortum RR, Gillenwater A, Shastri S, Chaturvedi P. Evaluation of a Low-Cost, Portable Imaging System for Early Detection of Oral Cancer. Head & Neck Oncology 2(10), 2010. e-Pub 2010. PMID: 20409347.
- Fingeret MC, Vidrine DJ, Reece GP, Gillenwater AM, Gritz ER. Multidimensional analysis of body image concerns among newly diagnosed patients with oral cavity cancer. Head Neck 32(3):301-9, 2010. e-Pub 2010. PMID: 19626634.
- Ghosn B, van de Ven AL, Tam J, Gillenwater AM, Sokolov KW, Richards-Kortum R, Roy K. Efficient mucosal delivery of optical contrast agents using imidazole-modified chitosan. J Biomed Opt 15(1):015003, 2010. e-Pub 2010. PMID: 20210443.
- Levy L, Smith C, Gurudutt V, Teng M, Rivera M, Anadasabapathy S, Genden E, Gillenwater A, Richards-Kortum R, Sikora A. Ex vivo high resolution imaging with a miniaturized microendoscope to discriminate between benign and malignant mucosa in the upper aerodigestive tract. Laryngoscope 120 Suppl 4:S162, 2010. e-Pub 2010. PMID: 21225760.
- Wang LE, Hu Z, Sturgis EM, Spitz MR, Strom SS, Amos CI, Guo Z, Qiao Y, Gillenwater AM, Myers JN, Clayman GL, Weber RS, El-Naggar AK, Mao L, Lippman SM, Hong WK, Wei Q. Reduced DNA repair capacity for removing tobacco carcinogen-induced DNA adducts contributes to risk of head and neck cancer but not tumor characteristics. Clin Cancer Res 16(2):764-74, 2010. e-Pub 2010. PMID: 20068090.
- Vigneswaran N, Koh S, Gillenwater A. Incidental detection of an occult oral mailgnancy with autofluorescence imaging: a case report. Head Neck Oncol 1(1):37, 2009. e-Pub 2009. PMID: 19863814.
- Funk E, Ivan D, Gillenwater AM. Ecthyma Gangrenosum: An Unusual Cutaneous Manifestation of the Head and Neck. Arch Otolaryngol Head Neck Surg 135(8):818-820, 2009. e-Pub 2009. PMID: 19687405.
- Nitin N, Rosbach KJ, El-Naggar A, Williams M, Gillenwater A, Richards-Kortum RR. Optical Molecular Imaging of Epidermal Growth Factor Receptor Expression to Improve Detection of Oral Neoplasia. Neoplasia 11(6):542-551, 2009. e-Pub 2009. PMID: 19484143.
- Roblyer D, Kurachi C, Stepanek V, Williams MD, El-Naggar AK, Lee JJ, Gillenwater AM, Richards-Kortum R. Objective detection and delineation of oral neoplasia using autofluorescence imaging. Cancer Prev Res 2(5):423-31, 2009. e-Pub 2009. PMID: 19401530.
- Holsinger FC, Kies MS, Jr DE, Gillenwater AM, Lewin JS, Ginsberg LE, Glisson BS, Garden AS, Ark N, Lin HY, Lee JJ, El-Naggar AK, Hong WK, Shin DM, Khuri FR. Durable long-term remission with chemotherapy alone for stage II to IV laryngeal cancer. J Clin Oncol 27(12):1976-1982, 2009. e-Pub 2009. PMID: 19289628.
- Papadimitrakopoulou V, Izzo JG, Liu DD, Myers J, Ceron TL, Lewin J, Jr WW, Atwell A, Lee JJ, Gillenwater A, El-Naggar A, Wu X, Lippman SM, Hittelman WN, Hong WK. Cyclin D1 and cancer development in laryngeal premalignancy patients. Cancer Prev Res 2(1):14-21, 2009. e-Pub 2009. PMID: 19139013.
- Pavlova I, Weber CR, Schwarz RA, Williams MD, Gillenwater AM, Richards-Kortum R. Fluorescence spectroscopy of oral tissue: Monte Carlo modeling with site-specific tissue properties. J Biomed Opt 14(1):014009, 2009. e-Pub 2009. PMID: 19256697.
- Schwarz RA, Gao W, Weber CR, Kurachi C, Lee JJ, El-Naggar AK, Richards-Kortum R, Gillenwater AM. Noninvasive evaluation of oral lesions using depth-sensitive optical spectroscopy. Cancer 115(8):1669-1679, 2009. e-Pub 2009. PMID: 19170229.
- Tsao AS, Liu D, Martin J, Tang XM, Lee JJ, El-Naggar AK, Wistuba I, Culotta KS, Mao L, Gillenwater A, Sagesaka YM, Hong WK, Papadimitrakopoulou V. Phase II randomized, placebo-controlled trial of green tea extract in patients with high-risk oral premalignant lesions. Cancer Prev Res 2(11):931-41, 2009. e-Pub 2009. PMID: 19892663.
- Nitin N, Carlson AL, Muldoon T, El-Naggar AK, Gillenwater A, Richards-Kortum R. Molecular imaging of glucose uptake in oral neoplasia following topical application of fluorescently labeled deoxy-glucose. Int J Cancer 124(11):2634-42, 2009. e-Pub 2009. PMID: 19173294.
- Pavlova I, Weber CR, Schwarz RA, Williams R, El-Naggar A, Gillenwater A, Richards-Kortum R. Monte Carlo model to describe depth selective fluorescence spectra of epithelial tissue: applications for diagnosis of oral precancer. J Biomed Opt 13(6):064012, 2008. e-Pub 2008. PMID: 19123659.
- Yildirim G, Gillenwater AM, Ordonez NG, Garden AS, El-Naggar AK. Concurrent epithelioid malignant peripheral nerve sheath tumor and papillary thyroid carcinoma in the treated field of Hodgkin's disease. Head Neck 30(5):675-9, 2008. e-Pub 2008. PMID: 17972308.
- Maitland KC, Gillenwater AM, Williams MD, El-Naggar AK, Descour MR, Richards-Kortum RR. In Vivo Imaging of Oral Neoplasia using a Miniaturized Fiber Optic Confocal Reflectance Microscope. Oral Oncol 44(11):1059-1066, 2008. e-Pub 2008. PMID: 18396445.
- Pavlova I, Williams MD, El-Naggar A, Richards-Kortum R, Gillenwater A. Understanding the biological basis of autofluorescence imaging for oral cancer detection: high resolution fluorescence microscopy in viable tissue. Clin Cancer Res 14(8):2396-404, 2008. e-Pub 2008. PMID: 18413830.
- Schwarz RA, Gao W, Daye D, Williams MD, Richards-Kortum R, Gillenwater AM. Autofluorescence and diffuse reflectance spectroscopy of oral epithelial tissue using a depth-sensitive fiber-optic probe. Appl Opt 47(6):825-834, 2008. e-Pub 2008. PMID: 18288232.
- Roblyer D, Richards-Kortum R, Sokolov K, El-Naggar AK, Williams MD, Kurachi C, Gillenwater AM. Multispectral optical imaging device for in vivo detection of oral neoplasia. J Biomed Opt 13(2):024019, 2008. e-Pub 2008. PMID: 18465982.
- Neiman LT, Kan CW, Gillenwater A, Markey MK, Sokolov K. Probing local tissue changes in the oral cavity for early detection of cancer using oblique polarized reflectance spectroscopy: a pilot clinical trial. J Biomed Opt 13(2):024011, 2008. e-Pub 2008. PMID: 18465974.
- Rahman M, Chaturvedi P, Gillenwater AM, Richards-Kortum R. Low-cost, multimodal, portable screening system for early detection of oral cancer. J Biomed Opt 13(3):030502, 2008. e-Pub 2008. PMID: 18601519.
- Gillenwater AM, Zhong M, Lotan R. Histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis through both mitochondrial and Fas (Cd95) signaling in head and neck squamous carcionoma cells. Mol Cancer Ther 6(11):2967-2975, 2007. e-Pub 2007. PMID: 18025281.
- Debnam JM, Gillenwater AM, Ginsberg LE. Nasal septal abscess in patients with immunosuppression. AJNR Am J Neuroradiol 10:1878-9, 2007. e-Pub 2007. PMID: 17905891.
- Carlson AL, Coghlan LG, Gillenwater AM, Richards-Kortum R. Dual-mode reflectance and fluorescence near-video-rate confocal microscope for architectural, morphological and molecular imaging of tissue. J Microsc 228(1):11-24, 2007. e-Pub 2007. PMID: 17910693.
- Carlson AL, Gillenwater AM, Williams MD, El-Naggar AK, Richards-Kortum R. Confocal microscopy and molecular-specific optical contrast agents for the detection of oral neoplasia. Technol Cancer Res Treat 6(5):361-74, 2007. e-Pub 2007. PMID: 17877424.
- Arifler D, Pavlova I, Gillenwater A, Richards-Kortum R. Light scattering from collagen fiber networks: micro-optical properties of normal and neoplastic stroma. Biophysl J 92(9):3260-74, 2007. e-Pub 2007. PMID: 17307834.
- Muldoon TJ, Pierce MC, Nida DL, Williams MD, Gillenwater A, Richards-Kortum. Subcellular-resolution molecular imaging within living tissue by fiber microendoscopy. Opt Express 15(25):16413-23, 2007. e-Pub 2007. PMID: 19550931.
- Truong AT, Truong DT, Gillenwater AM, Rozner MA. Gastric aspiration in patients with a laryngectomy stoma: is it possible?. J Clin Anesth 18:557-8, 2006. e-Pub 2006. PMID: 17126793.
- Safdar A, Gillenwater AM, Jones DM, Jorgensen JL, Romaguera JE. Rosi-Dorfman disease misdiagnosed as active tuberculosis. Leuk Lymphoma 47:1441-2, 2006. e-Pub 2006. PMID: 16923590.
- Hsu ER, Gillenwater AM, Hasan MQ, Williams MD, El-Naggar AK, Richards-Kortum RR. Real-time detection of epidermal growth factor receptor expression in fresh oral cavity biopsies using a molecular-specific contrast agent. Int J Cancer 118:3062-71, 2006. e-Pub 2006. PMID: 16395711.
- Takada Y, Gillenwater A, Ichikawa H, Aggarwal BB. Suberoylanilide hydroxamic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing nuclear factor-kappaB activation. J Biol Chem 281:5612-22, 2006. e-Pub 2006. PMID: 16377638.
- Lewin JS, Barringer DA, May AH, Gillenwater AM, Arnold KA, Roberts DB, Yu P. Functional outcomes after laryngopharyngectomy with anterolateral thigh flap reconstruction. Head Neck 28(2):142-9, 2006. e-Pub 2006. PMID: 16302192.
- Hsu ER, Gillenwater AM, Richards-Kortum RR. Detection of the molecular changes associated with oral cancer using a molecular-specific fluorescent contrast agent and single-wavelength spectroscopy. Appl Spectrosc 59:1166-73, 2005. e-Pub 2005. PMID: 16197641.
- Lewin JS, Barringer DA, May AH, Gillenwater AM, Arnold KA, Roberts DB, Yu P. Functional outcomes after circumferential pharyngoesophageal reconstruction. Laryngoscope 115(7):1266-71, 2005. e-Pub 2005. PMID: 15995519.
- Gillenwater A, Lewin J, Roberts D, El-Naggar A. Moderately Differentiated Neuoendocrine Carcinoma (Atypical carcinoid) of the Larynx: A Clinically Aggressive Tumor. Laryngoscope 115(7):1191-5, 2005. e-Pub 2005. PMID: 15995505.
- Schwarz RA, Arifler D, Chang SK, Pavlova I, Hussain IA, Mack V, Knight B, Richards-Kortum R, Gillenwater AM. Ball lens coupled fiber-optic probe for depth-resolved spectroscopy of epithelial tissue. Opt Lett 30:1159-61, 2005. e-Pub 2005. PMID: 15945140.
- Tomsett KL, Chambers MS, Martin JW, Gillenwater AM, Lemon JC. A technique for the fabrication of an immediate mandibular surgical stent securing a skin graft. J Prosthet Dent 93(4):395-7, 2005. e-Pub 2005. PMID: 15798691.
- Carlson K, Chidley M, K-B S, Descour M, Gillenwater A, Follen M, Richards-Kortum R. In vivo fiber-optic confocal reflectance microscope with an injection-molded plastic miniature objective lens. Applied Optics 44:1792-1797, 2005. e-Pub 2005. PMID: 15813514.
- Clark AL, Gillenwater A, Alizadeh-Naderi R, El-Naggar AK, Richards-Kortum R. Detection and Diagnosis of oral neoplasia with an optical coherence microscope. J Biomed Opt 9(6):1271-80, 2004. e-Pub 2004. PMID: 15568948.
- Hsu ER, Anslyn EV, Dharmawardhane S, Alizadeh-Naderi R, Aaron JS, Sokolov KV, El-Naggar AK, Gillenwater AM, Richards-Kortum RR. A far-red fluorescent contrast agent to image epidermal growth factor receptor expression. Photochem Photobiol 79(3):272-9, 2004. e-Pub 2004. PMID: 15115300.
- Svistun E, Alizadeh-Naderi R, El-Naggar A, Jacob R, Gillenwater A, Richards-Kortum R. Vision Enhancement System for Detection of Oral Cavity Neoplasia based on Autofluorescence. Head Neck 26(3):205-215, 2004. e-Pub 2004. PMID: 14999795.
- Sokolov K, Neiman LT, Myakov A, Gillenwater A. Polarized reflectance spectroscopy for pre-cancer detection. Technol Cancer Res Treat 3(1):1-14, 2004. e-Pub 2004. PMID: 14750888.
- Sokolov K, Aaron J, Hsu B, Nida D, Gillenwater AM, et al. Optical systems for in vivo molecular imaging of cancer. Technol Cancer Res Treat 2(6):491-504, 2003. e-Pub 2003. PMID: 14640761.
- Papadimitrakopoulou VA, Ginsberg LE, Garden AS, Kies MS, Glisson BS, Diaz EM, Clayman G, Morrison WH, Liu DD, Blumenschein G, Lippman SM, Schommer D, Gillenwater A, et al. Intraarterial Cisplatin with Intravenous Paclitaxel and Ifosfamide as an Organ-Preservation Approach in Patients with Paranasal Sinus Carcinoma. Cancer 98(10):2214-23, 2003. e-Pub 2003. PMID: 14601092.
- Clark AL, Gillenwater AM, Collier TG, Alizadeh-Naderi R, El-Naggar AK, Richards-Kortum RR. Confocal microscopy for real-time detection of oral cavity neoplasia. Clin Cancer Res 9(13):4714-21, 2003. e-Pub 2003. PMID: 14581341.
- Esmaeli B, Ahmadi MA, Gillenwater AM, Faustina MM, Amato M. The role of supraorbital nerve biopsy in cutaneous malignancies of the periocular region. Ophthal Plast Reconstr Surg 19(4):282-6, 2003. e-Pub 2003. PMID: 12878876.
- Utzinger U, Bueeler M, Oh S, Heintzelman DL, Svistun ES, Abd-El-Barr A, Gillenwater A, Richards-Kortum R. Optimal Visual Perception and Detection of Oral Cavity Neoplasia. IEEE Trans Biomed Eng 50(3):396-399, 2003. e-Pub 2003. PMID: 12669997.
- Choi HR, Tucker SA, Huang Z, Gillenwater AM, Luna MA, Batsakis JG, El-Naggar AK. Differential expressions of cyclin-dependent kinase inhibitors (p27 and p21) and their relation to p53 and Ki-67 in oral squamous tumorigenesis. Int J Oncol 22(2):409-14, 2003. e-Pub 2003. PMID: 12527941.
- Lewin JS, Gillenwater AM, Garrett JD, Bishop-Leone JK, Nguyen DD, Callender DL, Ayers GD, Myers JN. Characterization of laryngopharyngeal reflux in patients with premalignant or early carcinomas of the larynx. Cancer 97(4):1010-4, 2003. e-Pub 2003. PMID: 12569600.
- Eicher SA, Clayman GL, Myers JN, Gillenwater AM. A prospective study of intraoperative lymphatic mapping for head and neck cutaneous melanoma. Arch Otolaryngol Head Neck Surg 128(3):241-6, 2002. e-Pub 2002. PMID: 11886337.
- Clark A, Collier T, Lacy A, Follen M, Malpica A, Gillenwater A, Richards-Kortum R. Detection of Dysplasia with Near Real Time Confocal Microscopy. Biomed Sci Instrum 38:393-8, 2002. e-Pub 2002. PMID: 12085638.
- Fiumara P, Snell V, Li Y, Mukhopadhyay A, Younes M, Gillenwater AM, Cabanillas F, Aggarwal BB, Younes A. Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines. Blood 98(9):2784-90, 2001. e-Pub 2001. PMID: 11675352.
- Shin DM, Khuri FR, Murphy B, Garden AS, Clayman G, Francisco M, Liu D, Glisson BS, Ginsberg L, Papadimitrakopoulou V, Myers J, Morrison W, Gillenwater A, et al. Combined interferon-alfa, 13-cis-retinoic acid, and alpha-tocopherol in locally advanced head and neck squamous cell carcinoma: novel bioadjuvant phase II trial. J Clin Oncol 19(12):3010-7, 2001. e-Pub 2001. PMID: 11408495.
- Gillenwater AM, Hessel AC, Morrison WH, Burgess M, Silva EG, Roberts D, Goepfert H. Merkel cell carcinoma of the head and neck: effect of surgical excision and radiation on recurrence and survival. Arch Otolaryngol Head Neck Surg 127(2):149-54, 2001. e-Pub 2001. PMID: 11177031.
- Lai S, Goepfert H, Gillenwater AM, Luna MA, El-Naggar AK. Loss of imprinting and genetic alterations of the cyclin-dependent kinase inhibitor p57KIP2 gene in head and neck squamous cell carcinoma. Clin Cancer Res 6(8):3172-6, 2000. e-Pub 2000. PMID: 10955800.
- Chan LL, Chong J, Gillenwater AM, Ginsberg LE. The pterygopalatine fossa: postoperative MR imaging appearance. AJNR Am J Neuroradiol 21(7):1315-9, 2000. e-Pub 2000. PMID: 10954286.
- Khuri FR, Nemunaitis J, Ganly I, Arseneau J, Tannock IF, Romel L, Gore M, Ironside J, MacDougall RH, Heise C, Randlev B, Gillenwater AM, Bruso P, Kaye SB, Hong WK, Kirn DH. a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer. Nat Med 6(8):879-85, 2000. e-Pub 2000. PMID: 10932224.
- Heintzelman DL, Utzinger U, Fuchs H, Zuluaga A, Gossage K, Gillenwater AM, Jacob R, Kemp B, Richards-Kortum RR. Optimal excitation wavelengths for in vivo detection of oral neoplasia using fluorescence spectroscopy. Photochem Photobiol 72(1):103-13, 2000. e-Pub 2000. PMID: 10911734.
- Esmaeli B, Wang B, Deavers M, Gillenwater A, Goepfert H, Diaz E, Eicher S. Prognostic Factors for Survival in Malignant Melanoma of the Eyelid Skin. Ophthal Plast Reconstr Surg 16(4):250-257, 2000. e-Pub 2000. PMID: 10923972.
- Gillenwater A, C-P Z, Zhong M, Lotan R. Effects of Sodium Butyrate on Growth, Differentiation, and Apoptosis in Head and Neck Squamous Carcinoma Cell Lines. Head & Neck 22(3):247-256, 2000. e-Pub 2000. PMID: 10748448.
- Lewin JS, Lemon J, Bishop-Leone JK, Leyk S, Martin JW, Gillenwater AM. Experience with Barton button and peristomal breathing valve attachments for hands-free tracheoesophageal speech. Head Neck 22(2):142-8, 2000. e-Pub 2000. PMID: 10679901.
- Shin DM, Mao L, Papadimitrakopoulou VM, Clayman G, El-Naggar A, Shin HJC, Lee JJ, Lee JS, Gillenwater A, Myers J, Lippman SM, Hittelman WN, Hong WK. Biochemopreventive Therapy for Patients with Premalignant Lesions of the Head and Neck and p53 Gene Expression. J Natl Cancer Inst 92(1):69-73, 2000. e-Pub 2000. PMID: 10620636.
- Papadimitrakopoulou VA, Clayman GL, Shin DM, Myers JN, Gillenwater AM, Goepfert H, El-Naggar AK, Lewin JS, Lippman SM, Hong WK. Biochemoprevention for dysplastic lesions of the upper aerodigestive tract. Arch Otolaryngol Head Neck Surg 125(10):1083-9, 1999. e-Pub 1999. PMID: 10522499.
- Gillenwater AM, Goepfert H. Surgical management of laryngotracheal and esophageal involvement by locally advanced thyroid cancer. Semin Surg Oncol 16(1):19-29, 1999. e-Pub 1999. PMID: 9890736.
- Zuluaga AF, Utzinger U, Durkin A, Fuchs H, Gillenwater AM, Jacob R, Kemp B, Fan J, Richards-Kortum R. Fluorescence excitation emission matrices of human tissue: A system for in vivo measurement and method of data analysis. Appl Spectrosc 53:302-11, 1999. e-Pub 1999.
- Gillenwater A, Jacob R, Ganeshappa R, Kemp B, El-Naggar AK, Palmer JL, Clayman G, Mitchell, MF, Richards-Kortum R. Noninvasive diagnosis of oral neoplasia based on fluorescence spectroscopy and native tissue autofluorescence. Arch Otolaryngol Head Neck Surg 124:1251-1258, 1998. e-Pub 1998. PMID: 9821929.
- Ballo MT, Garden AS, El-Naggar AK, Gillenwater AM, Morrison WH, Goepfert H, Ang KK. Radiation therapy for early stage (T1-T2) sarcomatoid carcinoma of true vocal cords: outcomes and patterns of failure. Laryngoscope 108(5):760-3, 1998. e-Pub 1998. PMID: 9591559.
- Shin DM, Glisson BS, Khuri FR, Ginsberg L, Papadimitrakopoulou V, Lee JJ, Lawhorn K, Gillenwater AM, Ang KK, Clayman GL, Callender DL, Hong WK, Lippman SM. Phase II trial of paclitaxel, ifosfamide, and cisplatin in patients with recurrent head and neck squamous cell carcinoma. J Clin Oncol 16(4):1325-30, 1998. e-Pub 1998. PMID: 9552033.
- Gillenwater A, X-C X, Estrov Y, Sacks P, Lotan D, Lotan R. Modulation of Galectin-1 content in human head and neck squamous carcinoma cells by sodium butyrate. Int J Cancer 75(2):217-24, 1998. e-Pub 1998. PMID: 9462711.
- Gillenwater A, Jacob R, Richards-Kortum R. Fluorescence spectroscopy: A technique with potential to improve the early detection of aerodigestive tract neoplasia. Head & Neck 20(6):556-62, 1998. e-Pub 1998. PMID: 9702544.
- Gillenwater A, Hurr K, Wolf P, Batsakis JG, Goepfert H, El-Naggar AK. Microsatellite alterations of chromosome 8q loci in pleomorphic adenoma. Otolaryngol-Head Neck Surg 117(5):448-452, 1997. e-Pub 1997. PMID: 9374165.
- El-Naggar AK, Dinh M, Tucker SL, Gillenwater A, Luna MA, Batsakis JG. Chromosomal and DNA ploidy characterization of salivary gland neoplasms by combined FISH and flow cytometry. Hum Pathol 28(8):881-6, 1997. e-Pub 1997. PMID: 9269822.
- El-Naggar AK, Hurr K, Kagan J, Gillenwater A, Callender D, Luna MA, Batsakis JG. Genotypic alterations in benign and malignant salivary gland tumors: histogenetic and clinical implications. Am J Surg Pathol (US) 21(6):691-7, 1997. e-Pub 1997. PMID: 9199647.
- El-Naggar A, Hurr K, Kagan J, Gillenwater A, Callender D, Luna MA, Batsakis JG. Genotypic alterations in benign and malignant salivary gland tumors: histogenetic and clinical implications. Am J Surg Pathol 21(6):691-7, 1997. e-Pub 1997. PMID: 9199647.
- Gillenwater AM, X-C X, El-Naggar AK, Clayman GL, Lotan R. Expression of galectins in head and neck squamous carcinoma. Head Neck 18(5):422-432, 1996. e-Pub 1996. PMID: 8864733.
- Ginsberg LE, De Monte F, Gillenwater AM. Greater superficial petrosal nerve: anatomy and MR findings in perineural tumor spread. AJNR Am J Neuroradiol 17(2):389-93, 1996. e-Pub 1996. PMID: 8938317.
- Jahrsdoerfer RA, Gillenwater AM. The facial nerve in congenital ear malformations. Eur Arch Otorhinolaryngol:S299-301, 1994. e-Pub 1994. PMID: 10774379.
- Stiernberg CM, Jahrsdoerfer RA, Gillenwater AM, Joe SA, Alcalen SV. Gunshot wounds to the head and neck. Arch Otol 118:592-597, 1992. e-Pub 1992. PMID: 1637536.
- Spaulding CA, Gillenwater A, Constable WC, Hahn SS, Kersh CR. Prognostic value of vocal cord fixation with respect to treatment in cancers of the supraglottis and pyriform sinus. Laryngoscope 97:1450-1453, 1987. e-Pub 1987. PMID: 3683056.
Invited Articles
- Gillenwater A, Papadimitrakopoulou V, Richards-Kortum R. Oral premalignancy: new methods of detection and treatment. Curr Oncol Rep 8:146-54, 2006. e-Pub 2006. PMID: 16507225.
- Gillenwater AM, Jacob R, Richards-Kortum R. Fluorescence spectroscopy: a technique with potential to improve the early detection of aerodigestive tract neoplasia. Head Neck 20(6):556-562, 1998. e-Pub 1998. PMID: 9702544.
- Gillenwater AM, Weber RS. Thyroid carcinoma. Cancer Treat Res 90:149-69, 1997. e-Pub 1997. PMID: 9367082.
- Gillenwater AM. Head and Neck Cancer. Coping 9:40-41, 1995. e-Pub 1995.
Review Articles
- Yang EC, Tan MT, Schwarz RA, Richards-Kortum RR, Gillenwater AM, Vigneswaran N. Noninvasive diagnostic adjuncts for the evaluation of potentially premalignant oral epithelial lesions: current limitations and future directions. Oral Surg Oral Med Oral Pathol Oral Radiol 125(6):670-681, 2018. e-Pub 2018. PMID: 29631985.
- Schechter NR, Gillenwater AM, Byers RM, Garden AS, Morrison WH, Nguyen LN, Podoloff DA, Ang KK. Can positron emission tomography improve the quality of care for head-and-neck cancer patients?. Int J Radiat Oncol Biol Phys 51(1):4-9, 2001. e-Pub 2001. PMID: 11516844.
Editorials
- Gillenwater, AM, Vigneswaran, N, Sikora, AG. Assessing the Role of Inflammation in Oral Tongue Carcinogenesis. Journal of Clinical Oncology 42(15):1729-1730, 2024. PMID: 38635939.
Abstracts
- Curry JM, Fidler MJ, Johnson JM, Mott FE, Stenson K, Kochuparambil ST, McDonald DR, Tahara M, Vasan NR, Razaq MA, Campana JP, Ha P, Parmar H, Mann G, Ishida K, Cognetti DM, Gillenwater AM. RM-1929 photoimmunotherapy in patients with locoregional, recurrent head and neck squamous cell carcinoma (rHNSCC): Efficacy and safety results from a subgroup analysis in anti-PD1 treated and anti-PD1 naïve patients, 2021. e-Pub 2021.
- Coole J, Mitbander R, Brenes D, Vohra I, Hou H, Kortum A, Tang Y, Schwarz R, Carns J, Badaoui H, Williams M, Vigneswaran N, Gillenwater A, Richards-Kortum R. Optical Imaging to Optimize Biopsy Site Location, 2021. e-Pub 2021.
- Cognetti DM, Kochuparambil ST, Arron S, Yoshikawa H, Ishida K, Hou J, Gillenwater AM. Proof of concept for treating cutaneous squamous cell carcinoma with RM-1929 photoimmunotherapy: case examples of lesions with cutaneous involvement from a phase 1/2a trial of patients with recurrent head and neck squamous cell carcinoma, 2021. e-Pub 2021.
- P-J L, Gillenwater AM, Cognetti DM, Johnson JM, Arron S, Tahara M. A global phase 3 multicenter, randomized, double-arm, open-label trial of ASP-1929 photoimmunotherapy vs. physician’s choice standard of care for the treatment of patients with locoregional, recurrent head and neck squamous cell carcinoma (rHNSCC), 2021. e-Pub 2021.
- Mitbander R, Coole J, Brenes D, Kortum A, Vohra I, Carns J, Schwarz R, Badaoui H, Anandasivam L, Giese R, Vigneswaran N, Gillenwater A, Richards-Kortum R. Mobile-based Imaging System for Early Detection of Oral Premalignant Lesions at the Point of Care, 2021. e-Pub 2021.
- Gillenwater A, Cognetti D. Photoimmunotherapy: A New Approach to Loco-regionally Recurrent H&N Cancer, 2020. e-Pub 2020.
- Schwarz R, Pierce M, Bhattar V, Mondrick S, Williams M, Richards-Kortum R, Gillenwater A. Non-invasive identification of oral dysplasia with multi-modal optical imaging, 2012. e-Pub 2012.
- Gillenwater A, Schwarz RA, Bhattar V, Dhar S, Merry J, Mondrik S, Pierce M, Gao W, Williams MD, Vigneswaran N, Richards-Kortum R. Applications of Autofluorescence Imaging and Spectroscopy for Oral Cancer Surveillance, 2012. e-Pub 2012.
- Schwarz RA, Pierce MC, Bhattar V, Mondrik S, Williams MD, Gillenwater AM, Richards-Kortum R. Multimodal optical imaging for detection of oral neoplasia, 2012. e-Pub 2012.
- Schwarz RA, Pierce MC, Mondrik S, Gao W, Quinn MK, Bhattar VS, Williams MD, Vigneswaran N, Gillenwater AM, Richards-Kortum RR. Longitudinal evaluation of patients with oral potentially malignant disorders using optical imaging and spectroscopy, 2012. e-Pub 2012.
- Matin S, Kortum P, Williams T, Williams M, Huo L, Correa Refinetti AP, Gillenwater AM, Richards Kortum R. Human-Machine Function Allocation in an Automated Intraoperative Pathology System. International Symposium on Human Factors and Ergonomics in Health Care.
- Cognetti DM, Gillenwater AM. Recent safety and efficacy findings from a phase 1b/2 open-label combination study of ASP-1929 photoimmunotherapy with anti-PD-1 therapy in EGFR-expressing advanced head and neck squamous cell carcinoma (HNSCC). 2024 ASCO Annual Meeting.
- Wu J, Hou H, Sheyitov B, Liu J, Shende A, Bao X, Williams T, Carns J, Schwarz RA, Gillenwater AM, Williams M, Huo L, Refinetti AP, Tkaczyk TS, Horstmeyer R, Veeraraghavan A, Richards-Kortum RR. AccessPath: a deep learning extended depth-of-field array-microscope for rapid intraoperative tumor margin assessment. Computational Optical Imaging and Artificial Intelligence in Biomedical Sciences III.
Book Chapters
- Schwarz RA, Richards-Kortum RR, Gillenwater AM. Fluorescence and Reflectance Spectroscopy for Detection of Oral Dysplasia and Cancer. In: Biomedical Optics in Otorhinolaryngology Head and Neck Surgery. Springer, 431-450, 2016.
- Gillenwater AM. Evaluation of Oral Premalignant Lesions. In: Oral Cancer: Diagnosis, Management and Rehabilitation. 1. Thieme Medical Publishers, Inc, 31-37, 2007.
- Gillenwater AM, Sherman SI, El-Naggar AK, Goepfert H. Hurthle Cell Carcinoma of the Thyroid. In: Randolph: Surgery of the Thyroid and Parathyroid Glands. Elsevier Sciene, 227-231, 2003.
- Gillenwater AM, Lewin J, Blalock J, Goepfert H. Rehabilitation and Quality of Life. In: Multidisciplinary care of head and neck cancer: the MD Anderson approach.[Online], 2002.
- Gillenwater AM, Goepfert H, Ang KK, Gagel RF, Middleton LP, Kudelka AP. Thyroid. In: Multidisciplinary care of head and neck cancer: the MD Anderson approach.[Online], 2002.
- Sherman SI, Gillenwater AM. Neoplasms of the Thyroid. In: Cancer Medicine. B.C. Decker Inc, 1105-1114, 2000.
- Gillenwater AM, Byers RM, OMalley BB. Melanoma of the head and neck. In: Head and Neck Cancer: A Multidisciplinary Approach. Lippincott-Raven Publishers, 705-720, 2000.
- Byers RM, Gillenwater AM. The undetected primary cancer. In: Essentials of Head and Neck Oncology. Thieme Publishers, 2000.
- Sherman SI, Gillenwater AM, Goepfert H. Advances in the Management of Cancer of the Thyroid Gland. In: Advances in Otolaryngology-Head and Neck Surgery. Mosby, Inc, 2000.
Patents
- Richards-Kortum R, Utzinger U, Svistun ES, Gillenwater A. Vision Enhancement System for Improved Detection of Epithelial Neoplasia and Other Conditions. Patent Number: US 7,365,844 B2.
- Utzinger U, Durkin AJ, Fuchs H, Gillenwater AM, Heintzelman DL, Richards-Kortum RR. Combined fluorescence and reflectance spectroscopy. Patent Number: US 6,571,118.
- Richards-Kortum R, Schwarz RA, Gillenwater AM. Depth-Resolved Spectroscopy Method and Apparatus. Patent Number: US 7,499,161 B2.
Patient Reviews
CV information above last modified March 25, 2026