
Apostolia M. Tsimberidou, MD, PhD, FASCO, FAAAS
Department of Investigational Cancer Therapeutics, Division of Cancer Medicine
Featured Articles
Present Title & Affiliation
Primary Appointment
Tenured Professor, Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
Phase I Clinical Trials Target therapies Cancer Molecular Biology
Click here for the most up-to-date list of Dr. Tsimberidou's publications.
Education & Training
Degree-Granting Education
2022 | American Society of Clinical Oncology, Alexandria, VA, USA, FASCO, Precision Oncology |
2022 | American Association for the Advancement of Sciences, Washington, DC, USA, FAAAS, Precision Oncology |
2001 | Kapodistrian University of Athens, Athens, GRC, PHD, Multidrug resistance in acute myeloid leukemia |
1991 | Aristotelian University of Thessaloniki, Thessaloniki, GRC, MD, Medicine |
Postgraduate Training
2000-2001 | Postdoctoral Research Fellow, Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX |
1998-2000 | Postdoctoral Research Fellow, Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX |
1995-1998 | Fellow in Hematology, The University of Athens, First Department of Internal Medicine, Athens |
1993-1995 | Residency, Internal Medicine, Theagenion Cancer Hospital, Thessaloniki |
1992-1993 | Internship/Residency, Internal Medicine, G. Papanicolaou Hospital, Thessaloniki |
Board Certifications
2006 | ECFMG |
1999 | Board of Hematology, Athens, Greece, Valid for European Union Countries |
Experience & Service
Academic Appointments
Director of Seminars in Clinical Cancer Research, University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX, 2015 - 2018
Tenured Associate Professor, Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2010 - 2016
Associate Member, University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX, 2009 - Present
Assistant Professor, Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2007 - 2010
Assistant Professor, Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2004 - 2007
Instructor, Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2001 - 2004
Administrative Appointments/Responsibilities
Member, Clinical Trials Committee, Worldwide Innovative Network (WIN), Paris, 2016 - 2020
Chair, Clinical Research Committee, American Society of Clinical Oncology (ASCO), Washington, DC, 2016 - 2017
Co-Chair, Molecular Tumor Board ASCO's Targeted Agent and Profiling Utilization Registry (TAPUR), Alexandria, VA, 2015 - Present
Member, 2015 ASCO Educational Book Expert Panel, Alexandria, VA, 2015 - Present
Chair, Elect, Clinical Research Committee, American Society of Clinical Oncology (ASCO), Washington, DC, 2015 - 2016
Member, The University of Texas MD Anderson Cancer Center, Alexandria, VA, 2012 - 2014
Member, ASCO Cancer Educational Committee, Alexandria, VA, 2012 - 2015
Institutional Committee Activities
Co-Chair, Investigational Cancer Therapeutics Compassionate and Understanding Committee, 2014 - 2015
Associate Member, The University of Texas Health Science Center Graduate School of Biomedical Sciences, 2009 - 2011
Honors & Awards
2014 | Leader in Healthcare, Doctors of Excellence |
2014 | Strathmore's Who's Who |
2013 | Leadership Development Program, American Society of Clinical Oncology |
2010 | Cambridge Who's Who, Cambridge Who's Who Registry of Executives, Professionals and Entrepreneurs |
2010 | Faculty Leadership Academy, University of Texas MD Anderson Cancer Center |
2007 | Career Development Award, American Society of Clinical Oncology |
2007 | Travel Award, European Hematology Association |
2006 | Woman of the Year for the Science category, Life and Style, Athens, Greece |
2005 | Junior Faculty Scholarship, Therapeutic Advances in the Treatment of Hematological Malignancies Conference |
2000 | American Society of Clinical Oncology Merit Award, American Society of Clinical Oncology |
2000 | American Society of Hematology Travel Award, American Society of Hematology |
1997 | Arkagathos Gouttas, Hellenic Society of Hematology |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Tsimberidou AM, Hong DS, Ye Y, Cartwright C, Wheler JJ, Falchook GS, Naing A, Fu S, Piha-Paul S, Janku J, Meric-Bernstam F, Hwu P, Kee B, Kies MS, Broaddus R, Mendelsohn J, Hess KR, Kurzrock R. Initiative for molecular profiling and advanced cancer therapy (IMPACT): an MD Anderson precision medicine study. JCO Precis Oncol 1:PO.17.00002, 2017. e-Pub 2017. PMID: 29082359.
- Subbiah IM, Tsimberidou A, Subbiah V, Janku F, Roy-Chowdhuri S, Hong DS. Next generation sequencing of carcinoma of unknown primary reveals novel combinatorial strategies in a heterogeneous mutational landscape. Oncoscience 4(5-6):47-56, 2017. e-Pub 2017. PMID: 28781987.
- Li MM*, Datto M*, Duncavage EJ*, Kulkarni S*, Lindeman NI*, Roy S*, Tsimberidou AM*, Vnencak-Jones CL*, Wolff DJ*, Younes A*, Nikiforova MN*. Standards and guidelines for the interpretation and reporting of sequence variants in cancer: A joint consensus recommendation of the association for molecular pathology, American Society of Clinical Oncology, and College of American Pathologists. J Mol Diagn 19(1):4-23, 2017. PMID: 27993330.
- Reilley MJ, Bailey A, Subbiah V, Janku F, Naing A, Falchook G, Karp D, Piha-Paul S, Tsimberidou AM, Fu S, Lim J, Bean S, Bass A, Montez S, Vence L, Sharma P, Allison J, Meric-Bernstam F, Hong DS. Phase I clinical trial of combination imatinib and ipilimumab in patients with advanced malignancies. J Immunother Cancer 5:35, 2017. e-Pub 2017. PMID: 28428884.
- Hong DS, Morris VK, El Osta B, Sorokin AV, Janku F, Fu S, Overman MJ, Piha-Paul S, Subbiah V, Kee B, Tsimberidou AM, Fogelman D, Bellido J, Shureiqi I, Huang H, Atkins J, Tarcic G, Sommer N, Lanman R, Meric-Bernstam F, Kopetz S. Phase IB study of vemurafenib in combination with irinotecan and cetuximab in patients with metastatic colorectal cancer with BRAFV600E mutation. Cancer Discov 6(12):1352-1365, 2016. e-Pub 2016. PMID: 27729313.
- Wang Z, Shi N, Naing A, Janku F, Subbiah V, Araujo DM, Patel SR, Ludwig JA, Ramondetta LM, Levenback CF, Ramirez PT, Piha-Paul SA, Hong D, Karp DD, Tsimberidou AM, Meric-Bernstam F, Fu S. Survival of patients with metastatic leiomyosarcoma: the MD Anderson Clinical Center for Targeted Therapy experience. Cancer Med 5(12):3437-3444, 2016. e-Pub 2016. PMID: 27882721.
- George GC, Iwuanyanwu EC, Anderson KO, Yusuf A, Zinner RG, Piha-Paul SA, Tsimberidou AM, Naing A, Fu S, Janku F, Subbiah V, Cleeland CS, Mendoza TR, Hong DS. Sleep quality and its association with fatigue, symptom burden, and mood in patients with advanced cancer in a clinic for early-phase oncology clinical trials. Cancer 122(21):3401-3409, 2016. PMID: 27412379.
- Wheler JJ, Janku F, Naing A, Li Y, Stephen B, Zinner R, Subbiah V, Fu S, Karp D, Falchook GS, Tsimberidou AM, Piha-Paul S, Anderson R, Ke D, Miller V, Yelensky R, Lee JJ, Hong D, Kurzrock R. TP53 alterations correlate with response to VEGF/VEGFR inhibitors: implications for targeted therapeutics. Mol Cancer Ther 15(10):2475-2485, 2016. e-Pub 2016. PMID: 27466356.
- Subbiah V, Hess KR, Khawaja MR, Wagner MJ, Tang C, Naing A, Fu S, Janku F, Piha-Paul S, Tsimberidou AM, Herzog CE, Ludwig JA, Patel S, Ravi V, Benjamin RS, Meric-Bernstam F, Hong DS. Evaluation of novel targeted therapies in aggressive biology sarcoma patients after progression from US FDA approved therapies. Sci Rep 6:35448, 2016. PMID: 27748430.
- Park H, Garrido-Laguna I, Naing A, Fu S, Falchook GS, Piha-Paul SA, Wheler JJ, Hong DS, Tsimberidou AM, Subbiah V, Zinner RG, Kaseb AO, Patel S, Fanale MA, Velez-Bravo VM, Meric-Bernstam F, Kurzrock R, Janku F. Phase I dose-escalation study of the mTOR inhibitor sirolimus and the HDAC inhibitor vorinostat in patients with advanced malignancy. Oncotarget 7(41):67521-67531, 2016. e-Pub 2016. PMID: 27589687.
- Hou MM, Wang Z, Janku F, Piha-Paul S, Naing A, Hong D, Westin S, Coleman RL, Sood AK, Tsimberidou AM, Subbiah V, Wheler J, Zinner R, Lu K, Meric-Bernstam F, Fu S. Continuous anti-angiogenic therapy after tumor progression in patients with recurrent high-grade epithelial ovarian cancer: Phase I trial experience. Oncotarget 7(23):35132-43, 2016. e-Pub 2016. PMID: 27147567.
- Janku F, Huang HJ, Claes B, Falchook GS, Fu S, Hong D, Ramzanali NM, Nitti G, Cabrilo G, Tsimberidou AM, Naing A, Piha-Paul SA, Wheler JJ, Karp DD, Holley VR, Zinner RG, Subbiah V, Luthra R, Kopetz S, Overman MJ, Kee BK, Patel S, Devogelaere B, Sablon E, Maertens G, Mills GB, Kurzrock R, Meric-Bernstam F. BRAF mutation testing in cell-free DNA from the plasma of patients with advanced cancers using a rapid, automated molecular diagnostics system. Mol Cancer Ther 15(6):1397-1404, 2016. e-Pub 2016. PMID: 27207774.
- Khawaja MR, Nick AM, Madhusudanannair V, Fu S, Hong D, McQuinn LM, Ng CS, Piha-Paul SA, Janku F, Subbiah V, Tsimberidou AM, Karp D, Meric-Bernstam F, Lu KH, Naing A. Phase I dose escalation study of temsirolimus in combination with metformin in patients with advanced/refractory cancers. Cancer Chemother Pharmacol 77(5):973-7, 2016. e-Pub 2016. PMID: 27014780.
- Said R, Kakadiaris E, Piha-Paul S, Fu S, Falchook G, Janku F, Wheler JJ, Zinner R, Hong DS, Kurzrock R, Tsimberidou AM. Phase I clinical trial of lenalidomide in combination with bevacizumab in patients with advanced cancer. Cancer Chemother Pharmacol 77(5):1097-102, 2016. e-Pub 2016. PMID: 27085994.
- Le Tourneau C, Kamal M, Tsimberidou AM, Bedard P, Pierron G, Callens C, Rouleau E, Vincent-Salomon A, Servant N, Alt M, Rouzier R, Paoletti X, Delattre O, Bièche I. Treatment algorithms based on tumor molecular profiling: the essence of precision medicine trials. J Natl Cancer Inst 108(4):1-10, 2016. e-Pub 2015. PMID: 26598514.
- Maiti A, Brown RE, Corn PG, Murthy R, Ganeshan DM, Tsimberidou AM, Subbiah V. Antitumor response to combined antiangiogenic and cytotoxic chemotherapy in recurrent metastatic chromophobe renal cell carcinoma: response signatures and proteomic correlates. Clin Genitourin Cancer 14(2):e187-93, 2016. e-Pub 2015. PMID: 26684814.
- Liu X, Kambrick S, Fu S, Naing A, Subbiah V, Blumenschein GR, Glisson BS, Kies MS, Tsimberidou AM, Wheler JJ, Zinner RG, Hong DS, Kurzrock R, Piha-Paul SA. Advanced malignancies treated with a combination of the VEGF inhibitor bevacizumab, anti-EGFR antibody cetuximab, and the mTOR inhibitor temsirolimus. Oncotarget 7(17):23227-38, 2016. e-Pub 2016. PMID: 26933802.
- Said R, Ye Y, Hong DS, Naing A, Falchook G, Fu S, Wheler JJ, Piha-Paul S, Tsimberidou AM. Phase I clinical trial of lenalidomide in combination with 5-fluorouracil, leucovorin, and oxaliplatin in patients with advanced cancer. Cancer Chemother Pharmacol 77(3):575-81, 2016. e-Pub 2016. PMID: 26825327.
- Tsimberidou AM. Targeted therapy in cancer. Cancer Chemother Pharmacol 76(6):1113-32, 2015. e-Pub 2015. PMID: 26391154.
- Tsimberidou AM, Kurzrock R. What defines precision medicine? Lessons learned from the SHIVA trial. Lancet Oncol 16(16):e579-80, 2015. PMID: 26678197.
- Subbiah IM, Falchook GS, Kaseb AO, Hess KR, Tsimberidou AM, Fu S, Subbiah V, Hong DS, Naing A, Piha-Paul SA, Akmal O, Janku F, Kurzrock R. Exploring response signals and targets in aggressive unresectable hepatocellular carcinoma: an analysis of targeted therapy phase 1 trials. Oncotarget 6(29):28453-62, 2015. e-Pub 2015. PMID: 26164085.
- Janku F, Claes B, Huang HJ, Falchook GS, Devogelaere B, Kockx M, Bempt IV, Reijans M, Naing A, Fu S, Piha-Paul SA, Hong DS, Holley VR, Tsimberidou AM, Stepanek VM, Patel SP, Kopetz ES, Subbiah V, Wheler JJ, Zinner RG, Karp DD, Luthra R, Roy-Chowdhuri S, Sablon E, Meric-Bernstam F, Maertens G, Kurzrock R. BRAF mutation testing with a rapid, fully integrated molecular diagnostics system. Oncotarget 6(29):26886-94, 2015. e-Pub 2015. PMID: 26330075.
- Janku F, Angenendt P, Tsimberidou AM, Fu S, Naing A, Falchook GS, Hong DS, Holley VR, Cabrilo G, Wheler JJ, Piha-Paul SA, Zinner RG, Bedikian AY, Overman MJ, Kee BK, Kim KB, Kopetz ES, Luthra R, Diehl F, Meric-Bernstam F, Kurzrock R. Erratum: Actionable mutations in plasma cell-free DNA in patients with advanced cancers referred for experimental targeted therapies. Oncotarget 6(27):24581, 2015. PMID: 26405159.
- Rodon J, Soria JC, Berger R, Batist G, Tsimberidou A, Bresson C, Lee JJ, Rubin E, Onn A, Schilsky RL, Miller WH, Eggermont AM, Mendelsohn J, Lazar V, Kurzrock R. Challenges in initiating and conducting personalized cancer therapy trials: perspectives from WINTHER, a worldwide innovative network (WIN) consortium trial. Ann Oncol 26(8):1791-8, 2015. e-Pub 2015. PMID: 25908602.
- Said R, Kurzrock R, Naing A, Hong DS, Fu S, Piha-Paul SA, Wheler JJ, Janku F, Kee BK, Bidyasar S, Lim J, Wallace M, Tsimberidou AM. Dose-finding study of hepatic arterial infusion of irinotecan-based treatment in patients with advanced cancers metastatic to the liver. Invest New Drugs 33(4):911-20, 2015. e-Pub 2015. PMID: 25990659.
- Meric-Bernstam F, Johnson A, Holla V, Bailey AM, Brusco L, Chen K, Routbort M, Patel KP, Zeng J, Kopetz S, Davies MA, Piha-Paul SA, Hong DS, Eterovic AK, Tsimberidou AM, Broaddus R, Bernstam EV, Shaw KR, Mendelsohn J, Mills GB. A decision support framework for genomically informed investigational cancer therapy. J Natl Cancer Inst 107(7), 2015. e-Pub 2015. PMID: 25863335.
- Hong DS, Janku F, Naing A, Falchook GS, Piha-Paul S, Wheler JJ, Fu S, Tsimberidou AM, Stecher M, Mohanty P, Simard J, Kurzrock R. Xilonix, a novel true human antibody targeting the inflammatory cytokine interleukin-1 alpha, in non-small cell lung cancer. Invest New Drugs 33(3):621-31, 2015. e-Pub 2015. PMID: 25822109.
- Rodrigues HV, Ke D, Lim J, Stephen B, Bellido J, Janku F, Zinner R, Tsimberidou A, Hong D, Piha-Paul S, Fu S, Naing A, Subbiah V, Karp D, Falchook G, Kurzrock R, Wheler J. Phase I combination of pazopanib and everolimus in PIK3CA mutation positive/PTEN loss patients with advanced solid tumors refractory to standard therapy. Invest New Drugs 33(3):700-9, 2015. e-Pub 2015. PMID: 25902899.
- Fu S, Hou MM, Naing A, Janku F, Hess K, Zinner R, Subbiah V, Hong D, Wheler J, Piha-Paul S, Tsimberidou A, Karp D, Araujo D, Kee B, Hwu P, Wolff R, Kurzrock R, Meric-Bernstam F. Phase I study of pazopanib and vorinostat: a therapeutic approach for inhibiting mutant p53-mediated angiogenesis and facilitating mutant p53 degradation. Ann Oncol 26(5):1012-8, 2015. e-Pub 2015. PMID: 25669829.
- Janku F, Angenendt P, Tsimberidou AM, Fu S, Naing A, Falchook GS, Hong DS, Holley VR, Cabrilo G, Wheler JJ, Piha-Paul SA, Zinner RG, Bedikian AY, Overman MJ, Kee BK, Kim KB, Kopetz ES, Luthra R, Diehl F, Meric-Bernstam F, Kurzrock R. Actionable mutations in plasma cell-free DNA in patients with advanced cancers referred for experimental targeted therapies. Oncotarget 6(14):12809-21, 2015. PMID: 25980577.
- Singh HM, Ungerechts G, Tsimberidou AM. Gene and cell therapy for pancreatic cancer. Expert Opin Biol Ther 15(4):1-12, 2015. e-Pub 2015. PMID: 25582170.
- Bilen MA, Fu S, Falchook GS, Ng CS, Wheler JJ, Abdelrahim M, Erguvan-Dogan B, Hong DS, Tsimberidou AM, Kurzrock R, Naing A. Phase I trial of valproic acid and lenalidomide in patients with advanced cancer. Cancer Chemother Pharmacol 75(4):869-74, 2015. e-Pub 2015. PMID: 25666183.
- Falchook GS, Moulder S, Naing A, Wheler JJ, Hong DS, Piha-Paul SA, Tsimberidou AM, Fu S, Zinner R, Janku F, Jiang Y, Huang M, Parkhurst KL, Kurzrock R. A phase I trial of combination trastuzumab, lapatinib, and bevacizumab in patients with advanced cancer. Invest New Drugs 33(1):177-86, 2015. e-Pub 2014. PMID: 25323060.
- Falchook GS, Wheler JJ, Naing A, Piha-Paul SA, Fu S, Tsimberidou AM, Hong DS, Janku F, Zinner R, Jiang Y, Huang M, Lin Q, Parkhurst K, Kurzrock R. Dual antiangiogenic inhibition: a phase I dose escalation and expansion trial targeting VEGF-A and VEGFR in patients with advanced solid tumors. Invest New Drugs 33(1):215-24, 2015. e-Pub 2014. PMID: 25363205.
- Wheler J, Yelensky R, Falchook G, Kim KB, Hwu P, Tsimberidou AM, Stephens PJ, Hong D, Cronin MT, Kurzrock R. Next generation sequencing of exceptional responders with BRAF-mutant melanoma: implications for sensitivity and resistance. BMC Cancer 15(1):61, 2015. e-Pub 2015. PMID: 25886620.
- Tsimberidou AM, Said R, Culotta K, Wistuba I, Jelinek J, Fu S, Falchook G, Naing A, Piha-Paul S, Zinner R, Siddik ZH, He G, Hess K, Stewart DJ, Kurzrock R, Issa JP. Phase I study of azacitidine and oxaliplatin in patients with advanced cancers that have relapsed or are refractory to any platinum therapy. Clin Epigenetics 7(1):29, 2015. e-Pub 2015. PMID: 25806091.
- Liu X, George GC, Tsimberidou AM, Naing A, Wheler JJ, Kopetz S, Fu S, Piha-Paul SA, Eng C, Falchook GS, Janku F, Garrett C, Karp D, Kurzrock R, Zinner R, Raghav K, Subbiah V, Hess K, Meric-Bernstam F, Hong DS, Overman MJ. Retreatment with anti-EGFR based therapies in metastatic colorectal cancer: impact of intervening time interval and prior anti-EGFR response. BMC Cancer 15(1):713, 2015. e-Pub 2015. PMID: 26474549.
- Fu S, Shi N, Wheler J, Naing A, Janku F, Piha-Paul S, Gong J, Hong D, Tsimberidou AM, Zinner R, Subbiah V, Hou MM, Ramirez P, Ramondetta L, Lu K, Meric-Bernstam F. Characteristics and outcomes for patients with advanced vaginal or vulvar cancer referred to a phase I clinical trials program: the MD Anderson cancer center experience. Gynecol Oncol Res Pract 2:10, 2015. e-Pub 2015. PMID: 27231570.
- Hong DS, Henary H, Falchook GS, Naing A, Fu S, Moulder S, Wheler JJ, Tsimberidou AM, Durand JB, Khan R, Yang P, Johansen M, Newman RA, Kurzrock R. First-in-human study of pbi-05204, an oleander-derived inhibitor of Akt, FGF-2, NF-kβ and p70S6K, in patients with advanced solid tumors. Invest New Drugs 32(6):1204-12, 2014. e-Pub 2014. PMID: 24919855.
- Ganesan P, Moulder S, Lee JJ, Janku F, Valero V, Zinner RG, Naing A, Fu S, Tsimberidou AM, Hong D, Stephen B, Stephens P, Yelensky R, Meric-Bernstam F, Kurzrock R, Wheler JJ. Triple-negative breast cancer patients treated at MD Anderson Cancer Center in phase I trials: improved outcomes with combination chemotherapy and targeted agents. Mol Cancer Ther 13(12):3175-84, 2014. e-Pub 2014. PMID: 25253784.
- Jardim DL, Tang C, Gagliato Dde M, Falchook GS, Hess K, Janku F, Fu S, Wheler JJ, Zinner RG, Naing A, Tsimberidou AM, Holla V, Li MM, Roy-Chowdhuri S, Luthra R, Salgia R, Kurzrock R, Meric-Bernstam F, Hong DS. Analysis of 1,115 patients tested for MET amplification and therapy response in the MD Anderson Phase I Clinic. Clin Cancer Res 20(24):6336-45, 2014. e-Pub 2014. PMID: 25326232.
- Tang C, Hess K, Jardim DL, Gagliato Dde M, Tsimberidou AM, Falchook G, Fu S, Janku F, Naing A, Piha-Paul S, Subbiah V, Wheler J, Zinner RG, Kurzrock R, Ellis LM, Meric-Berstam F, Hong DS. Synergy between VEGF/VEGFR inhibitors and chemotherapy agents in the phase I clinic. Clin Cancer Res 20(23):5956-63, 2014. e-Pub 2014. PMID: 25316815.
- Hou MM, Liu X, Wheler J, Naing A, Hong D, Coleman RL, Tsimberidou A, Janku F, Zinner R, Lu K, Kurzrock R, Fu S. Targeted PI3K/AKT/mTOR therapy for metastatic carcinomas of the cervix: A phase I clinical experience. Oncotarget 5(22):11168-79, 2014. PMID: 25426553.
- Said R, Ye Y, Falchook GS, Janku F, Naing A, Zinner R, Blumenschein GR, Fu S, Hong DS, Piha-Paul SA, Wheler JJ, Kurzrock R, Palmer GA, Aldape K, Hess KR, Tsimberidou AM. Outcomes of patients with advanced cancer and KRAS mutations in phase I clinical trials. Oncotarget 5(19):8937-46, 2014. e-Pub 2014. PMID: 25313136.
- Tsimberidou AM, Keating MJ, Jabbour EJ, Ravandi-Kashani F, O'Brien S, Estey E, Bekele N, Plunkett WK, Kantarjian H, Borthakur G. A phase I study of fludarabine, cytarabine, and oxaliplatin therapy in patients with relapsed or refractory acute myeloid leukemia. Clin Lymphoma Myeloma Leuk 14(5):395-400.e1, 2014. e-Pub 2014. PMID: 24637132.
- Hong DS, Garrido-Laguna I, Ekmekcioglu S, Falchook GS, Naing A, Wheler JJ, Fu S, Moulder SL, Piha-Paul S, Tsimberidou AM, Wen Y, Culotta KS, Anderes K, Davis DW, Liu W, George GC, Camacho LH, Percy Ivy S, Kurzrock R. Dual inhibition of the vascular endothelial growth factor pathway: A phase 1 trial evaluating bevacizumab and AZD2171 (cediranib) in patients with advanced solid tumors. Cancer 120(14):2164-73, 2014. e-Pub 2014. PMID: 24752867.
- Tsimberidou AM, Wen S, Hong DS, Wheler JJ, Falchook GS, Fu S, Piha-Paul SA, Naing A, Janku F, Aldape KD, Ye Y, Kurzrock R, Berry DA. Personalized medicine for patients with advanced cancer in the phase I program at MD Anderson: validation and landmark analyses. Clin Cancer Res 20(18):4827-36, 2014. e-Pub 2014. PMID: 24987059.
- Corrales-Medina FF, Herzog C, Hess K, Egas-Bejar D, Hong DS, Falchook G, Anderson P, Nunez C, Huh WW, Naing A, Tsimberidou AM, Wheler J, Paul SP, Janku F, Kleinerman ES, Kurzrock R, Subbiah V. Clinical characteristics and outcomes of pediatric oncology patients with aggressive biology enrolled in phase I clinical trials designed for adults: The University of Texas MD Anderson Cancer Center experience. Oncoscience 1(7):522-30, 2014. PMID: 25587555.
- Fu S, Hou MM, Wheler J, Hong D, Naing A, Tsimberidou AM, Janku F, Zinner R, Piha-Paul S, Falchook G, Kuo MT, Kurzrock R. Exploratory study of carboplatin plus the copper-lowering agent trientine in patients with advanced malignancies. Invest New Drugs 32(3):465-72, 2014. e-Pub 2013. PMID: 24306314.
- Said R, Ye Y, Hong DS, Janku F, Fu S, Naing A, Wheler JJ, Kurzrock R, Thomas C, Palmer GA, Hess KR, Aldape K, Tsimberidou AM. Characteristics and survival of patients with advanced cancer and p53 mutations. Oncotarget 5(11):3871-9, 2014. PMID: 25003695.
- Janku F, Kaseb AO, Tsimberidou AM, Wolff RA, Kurzrock R. Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular Carcinoma using targeted next generation sequencing. Oncotarget 5(10):3012-22, 2014. PMID: 24931142.
- Hong DS, Hui D, Bruera E, Janku F, Naing A, Falchook GS, Piha-Paul S, Wheler JJ, Fu S, Tsimberidou AM, Stecher M, Mohanty P, Simard J, Kurzrock R. MABp1, a first-in-class true human antibody targeting interleukin-1α in refractory cancers: an open-label, phase 1 dose-escalation and expansion study. Lancet Oncol 15(6):656-66, 2014. e-Pub 2014. PMID: 24746841.
- Hou MM, Liu X, Wheler J, Naing A, Hong D, Bodurka D, Schmeler K, Tsimberidou AM, Janku F, Zinner R, Piha-Paul S, Hu CY, Lu K, Kurzrock R, Fu S. Outcomes of patients with metastatic cervical cancer in a phase I clinical trials program. Anticancer Res 34(5):2349-55, 2014. PMID: 24778042.
- Wheler JJ, Parker BA, Lee JJ, Atkins JT, Janku F, Tsimberidou AM, Zinner R, Subbiah V, Fu S, Schwab R, Moulder S, Valero V, Schwaederle M, Yelensky R, Miller VA, Stephens MP, Meric-Bernstam F, Kurzrock R. Unique molecular signatures as a hallmark of patients with metastatic breast cancer: Implications for current treatment paradigms. Oncotarget 5(9):2349-54, 2014. e-Pub 2014. PMID: 24811890.
- Wheler JJ, Moulder SL, Naing A, Janku F, Piha-Paul SA, Falchook GS, Zinner R, Tsimberidou AM, Fu S, Hong DS, Atkins JT, Yelensky R, Stephens PJ, Kurzrock R. Anastrozole and everolimus in advanced gynecologic and breast malignancies: activity and molecular alterations in the PI3K/AKT/mTOR pathway. Oncotarget 5(10):3029-38, 2014. PMID: 24912489.
- Ganesan P, Piha-Paul S, Naing A, Falchook G, Wheler J, Fu S, Hong DS, Kurzrock R, Janku F, Laday S, Bedikian AY, Kies M, Wolff RA, Tsimberidou AM. Phase I clinical trial of lenalidomide in combination with sorafenib in patients with advanced cancer. Invest New Drugs 32(2):279-86, 2014. e-Pub 2013. PMID: 23756764.
- Piha-Paul SA, Wheler JJ, Fu S, Levenback C, Lu K, Falchook GS, Naing A, Hong DS, Tsimberidou AM, Kurzrock R. Advanced gynecologic malignancies treated with a combination of the VEGF inhibitor bevacizumab and the MTOR inhibitor temsirolimus. Oncotarget 5(7):1846-55, 2014. PMID: 24742900.
- Wheler JJ, Janku F, Falchook GS, Jackson TL, Fu S, Naing A, Tsimberidou AM, Moulder SL, Hong DS, Yang H, Piha-Paul SA, Atkins JT, Garcia-Manero G, Kurzrock R. Phase I study of Anti-VEGF monoclonal antibody bevacizumab and histone deacetylase inhibitor valproic acid in patients with advanced cancers. Cancer Chemother Pharmacol 73(3):495-501, 2014. e-Pub 2014. PMID: 24435060.
- Tsimberidou AM, Adamopoulos AM, Ye Y, Piha-Paul S, Janku F, Fu S, Hong D, Falchook GS, Naing A, Wheler J, Fortier A, Kurzrock R, Hess KR. Phase I clinical trial of bendamustine and bevacizumab for patients with advanced cancer. J Natl Compr Canc Netw 12(2):194-203, 2014. PMID: 24586081.
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- Wheler JJ, Tsimberidou AM, Falchook GS, Zinner RG, Hong DS, Fok JY, Fu S, Piha-Paul SA, Naing A, Kurzrock R. Combining erlotinib and cetuximab is associated with activity in patients with non small cell lung cancer (including squamous cell carcinomas) and wild-type EGFR or resistant mutations. Mol Cancer Ther 12(10):2167-75, 2013. e-Pub 2013. PMID: 23963360.
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- Tam CS, O'Brien S, Lerner S, Khouri I, Ferrajoli A, Faderl S, Browning M, Tsimberidou AM, Kantarjian H, Wierda WG.. The natural history of fludarabine-refractory chronic lymphocytic leukemia patients who fail alemtuzumab or have bulky lymphadenopathy. Leuk Lymphoma 48(10):1931-9, 2007.
- Tsimberidou AM, Estey E, Kantarjian H, Keating MJ, Pierce S, Garcia-Manero G. Granulocyte colony stimulating factor administration associated with cerebral hemorrhage in acute promyelocytic leukemia. Leukemia 20(8):1452-3, 2006. e-Pub 2006. PMID: 16728980.
- Tsimberidou AM, Estey E. Induction mortality risk in adult acute myeloid leukemia. Leuk Lymphoma 47(7):1199-200, 2006. PMID: 16923545.
- Tsimberidou AM, Catovsky D, Schlette E, O'Brien S, Wierda WG, Kantarjian H, Garcia-Manero G, Wen S, Do KA, Lerner S, Keating MJ. Outcomes in patients with splenic marginal zone lymphoma and marginal zone lymphoma treated with rituximab with or without chemotherapy or chemotherapy alone. Cancer 107(1):125-35, 2006. PMID: 16700034.
- Tsimberidou AM, Giles FJ, Estey E, O'Brien S, Keating MJ, Kantarjian HM. The role of gemtuzumab ozogamicin in acute leukaemia therapy. Br J Haematol 132(4):398-409, 2006. PMID: 16412015.
- Tsimberidou AM, Tirado-Gomez M, Andreef M, O'Brien S, Kantarjian H, Keating MJ, Lopez-Berestein G, Estey E.. Single-agent liposomal all-trans retinoic acid can cure some patients with untreated acute promyelocytic leukemia: An update of the University of Texas M. D. Anderson Cancer Center series. Leuk Lymphoma 47(6):1062-8, 2006. PMID: 16840198.
- Garcia GM, Deavers MT, Knoblock R, Chen W, Tsimberidou AM, Manning JT, Medeiros LJ.. Myeloid sarcoma involving the gynecologic tract: a report of 11 cases and review of the literature. Am J Clin Pathol 125(5):783-90, 2006.
- Tsimberidou AM, Keating MJ, Bueso-Ramos CE, Kurzrock R. Epstein-Barr virus in patients with chronic lymphocytic leukemia: a pilot study. Leuk Lymphoma 47(5):827-36, 2006. PMID: 16753866.
- Liu Q, Fayad L, Cabanillas F, Hagemeister FB, Ayers GD, Hess M, Romaguera J, Rodriguez MA, Tsimberidou AM, Verstovsek S, Younes A, Pro B, Lee MS, Ayala A, McLaughlin P.. Improvement of overall and failure-free survival in stage IV follicular lymphoma: 25 years of treatment experience at the University of Texas M. D. Anderson Cancer Center. J Clin Oncol (Cover Sidebar) 24(10):1582-9, 2006. PMID: 16575009.
- Tsimberidou AM, O'Brien S, Khouri I, Giles FJ, Kantarjian HM, Champlin R, Wen S, Do K-A, Smith SC, Lerner S, Freireich EJ, Keating MJ.. Clinical outcomes and prognostic factors in patients with Richter's syndrome treated with chemotherapy or chemoimmunotherapy with or without stem cell transplantation. J Clin Oncol 24(15):2343-51, 2006. PMID: 16710033.
- Bruzzi JF, Macapinlac HA, Tsimberidou AM, Truong MT, Keating MJ, Marom EM, Munden RF.. Detection of Richter's transformation of chronic lymphocytic leukemia by PET/CT. J Nucl Med 47(8):1267-73, 2006. PMID: 16883004.
- Tsimberidou AM, O'Brien S, Kantarjian HM, Koller C, Hagemeister FB, Fayad L, Lerner S, Bueso-Ramos CE, Keating MJ.. Hodgkin transformation of chronic lymphocytic leukemia: the M. D. Anderson Cancer Center experience. Cancer 107(6):1294-302, 2006. PMID: 16902984.
- Ahmed B, Estey E, Manning J, David C, Keating MJ, Kantarjian H, Tsimberidou AM. Anaplastic large cell lymphoma with involvement of the pancreas presenting as panniculitis in a patient with a history of acute myeloid leukemia - case report and review of the literature. Haematologica 91(12 Suppl):ECR55, 2006. PMID: 17194661.
- Giles FJ, Kantarjian HM, Cortes JE, Faderl S, Verstovsek S, Thomas D, Garcia-Manero G, Wierda W, Ferrajoli A, Kornblau S, Mattiuzzi GN, Tsimberidou AM, Albitar M, O'Brien SM, Estey E. Adaptive randomized study of idarubicin and cytarabine alone or with interleukin-11 as induction therapy in patients aged 50 or above with acute myeloid leukemia or high-risk myelodysplastic syndromes. Leukemia Res 29(6):649-52, 2005. e-Pub 2005. PMID: 15863204.
- Estey E, Koller C, Tsimberidou AM, O'Brien S, Beran M, Cortes J, Tirado-Gomez M, Lopez-Berestein G, Kantarjian H. Potential curability of newly diagnosed acute promyelocytic leukemia without use of chemotherapy: the example of liposomal all-trans retinoic acid. Blood 105(3):1366-7, 2005. PMID: 15659618.
- Tsimberidou AM Giles FJ, Khouri I, Bueso-Ramos C, Pilat S, Thomas DA, Cortes J, Kurzrock R. Low-dose interleukin-11 in patients with bone marrow failure: update of the M. D. Anderson Cancer Center experience. Ann Oncol 16(1):139-45, 2005. PMID: 15598951.
- Tsimberidou AM, Younes A, Romaguera J, Hagemeister FB, Rodriguez MA, Feng L, Ayala A, Smith TL, Cabanillas F, McLaughlin P. Immunosuppression and infectious complications in patients with stage IV indolent lymphoma treated with a fludarabine, mitoxantrone, and dexamethasone regimen. Cancer 104(2):345-53, 2005. PMID: 15948158.
- Tsimberidou AM, Estey E, Whitman GJ, Dryden MJ, Ratnam S, Pierce S, Faderl S, Giles F, Kantarjian HM, Garcia-Manero G. Extramedullary relapse in a patient with acute promyelocytic leukemia: treatment with arsenic trioxide, all-trans retinoic acid and gemtuzumab ozogamicin therapies. Leukemia Res 28(9):991-4, 2004. PMID: 15234578.
- Tsimberidou AM, Giles FJ, Duvic M, Kurzrock R. Pilot study of etanercept in patients with relapsed cutaneous T-cell lymphomas. J Am Acad Dermatol 51(2):200-4, 2004. PMID: 15280837.
- Tsimberidou AM, Medina J, Cortes J, Rios A, Bonnie G, Faderl S, Kantarjian H, Garcia-Manero G. Chronic myeloid leukemia in a patient with acquired immune deficiency syndrome: complete cytogenetic response with imatinib mesylate: report of a case and review of the literature. Leukemia Res 28(6):657-60, 2004. PMID: 15120945.
- Tsimberidou AM, Murray JL, O'Brien S, Wierda WG, Keating MJ. Yttrium-90 ibritumomab tiuxetan radioimmunotherapy in Richter's syndrome. Cancer 100(10):2195-200, 2004. PMID: 15139064.
- Tsimberidou AM, Giles F, Romaguera J, Duvic M, Kurzrock R. Activity of interferon-alpha and isotretinoin in patients with advanced, refractory lymphoid malignancies. Cancer 100(3):574-80, 2004. PMID: 14745875.
- Tsimberidou AM, Giles F, Duvic M, Fayad L, Kurzrock R. Phase II study of pentostatin in advanced T-cell lymphoid malignancies: update of an M.D. Anderson Cancer Center series. Cancer 100(2):342-9, 2004. PMID: 14716770.
- Tsimberidou AM, Keating MJ, Giles FJ, Wierda WG, Ferrajoli A, Lerner S, Beran M, Andreeff M, Kantarjian HM, O'Brien S. Fludarabine and mitoxantrone for patients with chronic lymphocytic leukemia. Cancer 100(12):2583-91, 2004. PMID: 15197800.
- Tsimberidou AM, Colburn DE, Welch MA, Cortes JE, Verstovsek S, O'Brien SM, Albitar M, Kantarjian HM, Giles FJ. Anagrelide and imatinib mesylate combination therapy in patients with chronic myeloproliferative disorders. Cancer Chemother Pharmacol 52(3):229-34, 2003. e-Pub 2003. PMID: 12783207.
- Tsimberidou AM, Estey E, Cortes JE, Garcia-Manero G, Faderl S, Verstovsek S, Thomas DA, Ferrajoli A, Keating MJ, O'Brien S, Kantarjian HM, Giles FJ. Mylotarg, fludarabine, cytarabine, and cyclosporine regimen as post-remission therapy in acute myelogenous leukemia. Cancer Chemother Pharmacol 52(6):449-52, 2003. e-Pub 2003. PMID: 13680159.
- Apostolidou E, Cortes J, Tsimberidou A, Estey E, Kantarjian H, Giles FJ. Pilot study of gemtuzumab ozogamicin, liposomal daunorubicin, cytarabine and cyclosporine regimen in patients with refractory acute myelogenous leukemia. Leukemia Res 27(10):887-91, 2003. PMID: 12860007.
- Tsimberidou A, Cortes J, Thomas D, Garcia-Manero G, Verstovsek S, Faderl S, Albitar M, Kantarjian H, Estey E, Giles FJ. Gemtuzumab ozogamicin, fludarabine, cytarabine and cyclosporine combination regimen in patients with CD33+ primary resistant or relapsed acute myeloid leukemia. Leukemia Res 27(10):893-97, 2003. PMID: 12860008.
- Tsimberidou AM, Kantarjian HM, Estey E, Cortes JE, Verstovsek S, Faderl S, Thomas DA, Garcia-Manero G, Ferrajoli A, Manning JT, Keating MJ, Albitar M, O'Brien S, Giles FJ. Outcome in patients with nonleukemic granulocytic sarcoma treated with chemotherapy with or without radiotherapy. Leukemia 17(6):1100-3, 2003. PMID: 12764375.
- Tsimberidou AM, Waddelow T, Kantarjian HM, Albitar M, Giles FJ. Pilot study of recombinant human soluble tumor necrosis factor (TNF) receptor (p75) fusion protein (TNFR:Fc; Enbrel) in patients with refractory multiple myeloma: increase in plasma TNF alpha levels during treatment. Leukemia Res 27(5):375-80, 2003. PMID: 12620287.
- Apostolidou E, Estey E, Cortes J, Garcia-Manero G, Faderl S, Thomas D, Tsimberidou A, Kantarjian H, Giles FJ. Mitoxantrone and prolonged infusion gemcitabine as salvage therapy in patients with acute myelogenous leukemia. Leukemia Res 27(4):301-4, 2003. PMID: 12531220.
- Tsimberidou AM, Kantarjian HM, Cortes J, Thomas DA, Faderl S, Garcia-Manero G, Verstovsek S, Ferrajoli A, Wierda W, Alvarado Y, O'Brien SM, Albitar M, Keating MJ, Giles FJ. Fractionated cyclophosphamide, vincristine, liposomal daunorubicin, and dexamethasone plus rituximab and granulocyte-macrophage-colony stimulating factor (GM-CSF) alternating with methotrexate and cytarabine plus rituximab and GM-CSF in patients with Richter syndrome or fludarabine-refractory chronic lymphocytic leukemia. Cancer 97(7):1711-20, 2003. PMID: 12655528.
- Tsimberidou AM, Medina J, Earl M, Sierra M, Shriki JE, Bueso-Ramos C, Giralt S, Beran M, Giles FJ, Garcia-Manero G. Metastatic gastric adenocarcinoma following allogeneic stem cell transplantation in a patient with acute myelogenous leukemia. Bone Marrow Transplant 31(5):413-14, 2003. PMID: 12634736.
- Tsimberidou AM, Estey E, Cortes J, Thomas D, Faderl S, Verstovsek S, Garcia-Manero G, Keating M, Albitar M, O'Brien S, Kantarjian H, Giles F. Gemtuzumab, fludarabine, cytarabine, and cyclosporine in patients with newly diagnosed acute myelogenous leukemia or high-risk myelodysplastic syndromes. Cancer 97(6):1481-7, 2003. PMID: 12627513.
- Alvarado Y, Tsimberidou A, Kantarjian H, Cortes J, Garcia-Manero G, Faderl S, Thomas D, Estey E, Giles FJ. Pilot study of Mylotarg, idarubicin and cytarabine combination regimen in patients with primary resistant or relapsed acute myeloid leukemia. Cancer Chemother Pharmacol 51(1):87-90, 2003. e-Pub 2002. PMID: 12497211.
- Tsimberidou AM, Giles FJ, Kantarjian HM, Keating MJ, O'Brien SM. Anti-B4 blocked ricin post chemotherapy in patients with chronic lymphocytic leukemia-long-term follow-up of a monoclonal antibody-based approach to residual disease. Leuk Lymphoma 44(10):1719-25, 2003. PMID: 14692524.
- Tsimberidou AM, Stavroyianni N, Viniou N, Papaioannou M, Tiniakou M, Marinakis T, Skandali A, Sakellari I, Yataganas X. Comparison of allogeneic stem cell transplantation, high-dose cytarabine, and autologous peripheral stem cell transplantation as postremission treatment in patients with de novo acute myelogenous leukemia. Cancer 97(7):1721-31, 2003. PMID: 12655529.
- Yazji S, Giles FJ, Tsimberidou AM, Estey EH, Kantarjian HM, O'Brien SA, Kurzrock R. Antithymocyte globulin (ATG)-based therapy in patients with myelodysplastic syndromes. Leukemia 17(11):2101-06, 2003. PMID: 12931212.
- Cortes J, Tsimberidou AM, Alvarez R, Thomas D, Beran M, Kantarjian H, Estey E, Giles FJ. Mylotarg combined with topotecan and cytarabine in patients with refractory acute myelogenous leukemia. Cancer Chemother Pharmacol 50(6):497-500, 2002. e-Pub 2002. PMID: 12451477.
- Tsimberidou AM, Jiang Y, Ford RJ, Lichtiger B, Lee MS, Medeiros LJ, McLaughlin P, Cabanillas F, Sarris AS.. Quantitative real-time polymerase chain reaction for detection of circulating cells with t(14;18) in volunteer blood donors and patients with follicular lymphoma. Leuk Lymphoma 43(8):1589-98, 2002. PMID: 11842389.
- Tsimberidou AM, Alvarado Y, Giles FJ. Evolving role of ribonucleoside reductase inhibitors in hematologic malignancies. Expert Rev Anticancer Ther 2(4):437-48, 2002. PMID: 12647987.
- Tsimberidou AM, Giles FJ. TNF-alpha targeted therapeutic approaches in patients with hematologic malignancies. Expert Rev Anticancer Ther 2(3):277-86, 2002. PMID: 12113051.
- Tsimberidou AM, Giles FJ. Essential thrombocythemia: moving from palliation to cure. Hematology 7(6):315-23, 2002. PMID: 12475736.
- Tsimberidou AM, McLaughlin P, Younes A, Rodriguez MA, Hagemeister FB, Sarris A, Romaguera J, Hess M, Smith TL, Yang Y, Ayala A, Preti A, Lee MS, Cabanillas F. Fludarabine, mitoxantrone, dexamethasone compared with an alternating triple therapy regimen in patients with stage IV indolent lymphoma. Blood 100(13):4351-4357, 2002. PMID: 12393618.
- Tsimberidou AM, O'Brien SM, Cortes JE, Faderl S, Andreeff M, Kantarjian HM, Keating MJ, Giles FJ. Phase II study of fludarabine, cytarabine, cyclophosphamide, cisplatin and GM-CSF in patients with Richter's syndrome or refractory lymphoproliferative disorders. Leuk Lymphoma 43(4):767-72, 2002. PMID: 12153163.
- Tsimberidou AM, Paterakis G, Androutsos G, Anagnostopoulos N, Galanopoulos A, Kalmantis T, Meletis J, Rombos Y, Sagriotis A, Symeonidis A, Tiniakou M, Zoumbos N, Yataganas X. Evaluation of the clinical relevance of the expression and function of P-glycoprotein, multidrug resistance protein and lung resistance protein in patients with primary acute myelogenous leukemia. Leukemia Res 26(2):143-54, 2002. PMID: 11755464.
- Tsimberidou AM, Thomas D, O'Brien S, Andreeff M, Kurzrock R, Keating M, Albitar M, Kantarjian H, Giles F. Recombinant human soluble tumor necrosis factor receptor fusion protein Enbrel in patients with refractory hematologic malignancies. Cancer Chemother Pharmacol 50(3):237-42, 2002. PMID: 12203106.
- Tsimberidou AM, Sarris AH, Medeiros LJ, Mesina O, Rodriguez MA, Hagemeister FB, Romaguera J, Pro B, McLaughlin P, Dang N, Cabanillas F. Hodgkin's disease in patients infected with human immunodeficiency virus: frequency, presentation and clinical outcome. Leuk Lymphoma 41(5-6):535-44, 2001. PMID: 11378571.
- Sarris AH, Hagemeister F, Romaguera J, Rodriguez MA, McLaughlin P, Tsimberidou AM, Medeiros LJ, Samuels B, Pate O, Oholendt M, Kantarjian H, Burge C, Cabanillas F. Liposomal vincristine in relapsed non-Hodgkin's lymphomas: early results of an ongoing phase II trial. Ann Oncol 11(1):69-72, 2000. PMID: 10690390.
- Tsimberidou AM, Yataganas X. Mechanisms of multiple drug resistance (MDR) in hematologic malignancies and solid tumors. Iatriki 78:413-24, 2000.
- Meletis J, Samarkos M, Mesogitis S, Meletis C, Mougiou A, Terpos E, Tsimberidou A, Andreopoulos A, Konstantopoulos K, Loukopoulos D. Severe aplastic anaemia relapsing during a pregnancy; spontaneous remission following termination. Haematologia (Budapest) 29(2):147-51, 1998. PMID: 9728807.
- Meletis J, Tsimberidou A, Tsironi M, Stratigaki M, Meletis C, Samarkos M, Terpos E, Poziopoulos C, Konstantopoulos K, Loukopoulos D. Acute de novo basophilic leukemia presenting with skin involvement and upper gastrointestinal tract ulcerations. Haema 1:100-4, 1998.
- Meletis J, Terpos E, Tsimberidou A. Congenital dyserythropoietic anemia type II (HEMPAS). Archives of Hellenic Medicine 15:215, 1998.
- Meletis J, Terpos E, Tsimberidou A. Flashes in clinical haematology: Case 2. Haema 1:107, 1998.
- Michali E, Terpos E, Samarkos M, Meletis C, Tsimberidou A, Nodaros K, Vavourakis E, Konstantopoulos K, Kanellopoulou G, Variami E, Loukopoulos D, Meletis J. Detection of PNH red cell populations in hematologic disorders. Hippocrates 6:21-7, 1998.
- Meletis J, Michali E, Samarkos M, Konstantopoulos K, Meletis C, Terpos E, Tsimberidou A, Chandrinou E, Viniou N, Rombos Y, Pangalis GA, Yataganas X, Loukopoulos D. Detection of PNH red cell populations in hematological disorders using the Sephacryl Gel Test micro typing system. Leuk Lymphoma 28(1-2):177-82, 1997. PMID: 9498717.
- Meletis J, Terpos E, Tsimberidou A. Disseminated candida albicans infection in a patient with hereditary myeloperoxidase deficiency. Archives of Hellenic Medicine 14:338, 1997. e-Pub 1997.
Invited Articles
- Tsimberidou AM. Health policy: Strategies to optimize expedited investigational new drug safety reports. Nat Rev Clin Oncol 13(4):207-8, 2016. PMID: 26997460.
- Tsimberidou AM, Eggermont AM, Schilsky RL. Precision cancer medicine: The future is now, only better. Am Soc Clin Oncol Educ Book:61-9, 2014. e-Pub 2014. PMID: 24857061.
- Said R, Tsimberidou AM. Pharmacokinetic evaluation of vincristine for the treatment of lymphoid malignancies. Expert Opin Drug Metab Toxicol 10(3):483-94, 2014. e-Pub 2014. PMID: 24512004.
- Tsimberidou AM, Ringborg U, Schilsky RL. Strategies to overcome clinical, regulatory, and financial challenges in the implementation of personalized medicine. Am Soc Clin Oncol Educ Book:118-25, 2013. PMID: 23714475.
- Tsimberidou AM, Chandhasin C, Kurzrock R. Farnesyltransferase Inhibitors: Where are we now?. Expert Opin Investig Drugs 19(12):1569-80, 2010. e-Pub 2010. PMID: 21083522.
- Tsimberidou AM. Ofatumumab in the treatment of chronic lymphocytic leukemia. Drugs of Today - Prous Thomson Reuters 46(7):451-61, 2010. PMID: 20683500.
- Bustinza E, Kurzrock R, Tsimberidou AM. Salirasib in the treatment of pancreatic cancer. Future Oncology, (Cover Sidebar) 6(6):885-91, 2010.
- Tsimberidou AM, Keating MJ. Other malignancies in chronic lymphocytic leukemia/small lymhocytic lymphoma: Analysis of 2028 patients. Am J Hematol Oncol 8(9):430-2, 2009.
- Aguilera D, Tsimberidou AM. A review of dasatinib in the treatment of chronic myelogenous leukemia. Ther Clin Risk Manag 5:281-9, 2009.
- Tsimberidou AM, Keating MJ, Wierda WG.. Richter transformation in chronic lymphocytic leukemia. Curr Hematol Malig Rep 2(4):265-71, 2007. PMID: 20425379.
- Tsimberidou AM, Estey E.. Treatment of older patients with acute myeloid leukemia. Aging Health 3(5):663-73, 2007.
- Tsimberidou AM, Keating MJ. Richter's transformation in chronic lymphocytic leukemia. Semin Oncol 33(2):250-6, 2006. PMID: 16616072.
- Tsimberidou AM, Khouri I, Keating MJ.. Response, survival, failure-free survival, and prognostic factors in patients with Richter's syndrome treated with chemotherapy or chemoimmunotherapy with or without stem cell transplantation. Am J Clin Oncol 5(1):662-5, 2006.
- Tsimberidou AM, Keating MJ. Richter syndrome: biology, incidence, and therapeutic strategies. Cancer 103(2):216-28, 2005. PMID: 15578683.
- Tsimberidou AM, Keating MJ. Richter's syndrome: Biology, incidence, and therapeutic strategies. Am J Clin Oncol Review 4:392-7, 2005.
- Sarris AH, Jiang Y, Tsimberidou AM, Thomaides A, Rassidakis GZ, Ford RJ, Medeiros LJ, Cabanillas F, McLaughlin P.. Quantitative real-time polymerase chain reaction for monitoring minimal residual disease in patients with advanced indolent lymphomas treated with rituximab, fludarabine, mitoxantrone, and dexamethasone. Semin Oncol 29(Suppl 2):48-55, 2002.
- Tsimberidou AM. TNF-α targeted therapeutic approaches in patients with hematologic malignancies. Expert Rev Anticancer Ther 2(3):277-86, 2002.
- Tsimberidou AM, Alvarado Y, Giles FJ.. The evolving role of ribonucleotide reductase inhibitors in hematologic malignancies. Expert Rev Anticancer Ther 2(4):437-48, 2002.
Manuals, Teaching Aids, Other Teaching Publications
- Tsimberidou AM. Rituximab. The Encyclopedia of Cancer: Berlin, Heidelberg, 2009.
- Tsimberidou AM, Giles FJ. Chronic myelogenous leukemia. American College of Physicians, 2003.
Editorials
- Said R, Tsimberidou AM. Left ventricular ejection fraction in advanced cancer patients: a valuable prognostic tool?. Future Oncol 11(14):1999-2002, 2015. PMID: 26198825.
- Tsimberidou AM, Minotti G, Cardinale D. Managing cardiac risk factors in oncology clinical trials. Tex Heart Inst J 38(3):266-7, 2011. PMID: 21720468.
- Tsimberidou AM, Estey EH. The significance of anemia in elderly patients with cancer. Oncology (Cover Sidebar) 21(1):100,104, 2007.
- Tsimberidou AM, Estey E. Induction mortality risk in adult acute myeloid leukemia. Leuk Lymphoma 47(7):1199-1200, 2006.
Abstracts
- Mahalingam D, Patel M, Sachdev J, Hart LL, Halama N, Ramesh R, Liu X, Salim Y, Dirk J, Yoon MJ, GOzde M, Abid DR, Kerschbaumer R, Tsimberidou AM. Anti-oxidized macrophage migration inhibitory factor (oxMIF) antibody imalumab (BAX69) in advanced solid tumors: Final results of first-in-human phase 1 study. Ann Oncol; ESMO 2016 Congress 27(Suppl 6), 2016.
- Mahalingam D, Patel MR, Sachdev JC, Hart LL, Halama N, Ramanathan RK, Sarantopoulos J, Liu X, Yazji S, Jaeger D, Adib D, Kerschbaumer R, Tsimberidou AM. First-in-human phase 1 study assessing imalumab (BAX69), a first-in-class anti-oxidized macrophage migration inhibitory. Cancer Research: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research 76(14 Suppl), 2016.
- Mahalingam D, Patel M, Sachdev J, Hart L, Halama N, Ramanathan RK, Sarantopoulos J, Liu X, Yazji S, Jaeger D, Adib D, Kerschbaumer R, Yoon MJ, Manzur GC, Starodub A, Sivarajan K, Wertheim M, Thambi P, Jones M, Goel S, Nemunaitis J, Tsimberidou AM. Safety and efficacy analysis of imalumab, an anti-oxidized (ox) macrophage migration inhibitory factor (MIF) antibody, alone or in combination with 5-fluorouracil/leucovorin (5-FU/LV) or panitumumab, in patients with metastatic colorectal cancer (mCRC). Ann Oncol; ESMO World Congress on GI Cancer (WCGIC) 27(Suppl 2):ii105, 2016.
- Sen S, Rao A, Janku F, Hong DS, Tsimberidou AM, Piha-Paul SA, Heymach J, Byers LA, Meric-Bernstam F, Subbiah V. Co-occurring genomic alterations and association with progression free survival in BRAFV600 mutated non-melanoma tumors treated with BRAF inhibitor. J Clin Oncol, 2016 ASCO Annual Meeting 34(15 Suppl), 2016.
- Tang C, Welsh JW, de Groot P, Massarelli E, Chang JY, Hess KR, Curran MA, Cabanillas ME, Subbiah V, Fu S, Tsimberidou AM, Karp DD, Gomez DR, Komaki R, Sharma P, Naing A, Hong DS. Phase I trial combining ipilimumab + high dose stereotactic radiation: Results and serum immune correlates. J Clin Oncol, 2016 ASCO Annual Meeting 34(15 Suppl), 2016.
- Westin SN, Stashi E, Pal N, Urbauer DL, Janku F, Piha-Paul SA, Naing A, Tsimberidou AM, Fu S, Hong DS, Subbiah V, Karp DD, Coleman RL, Meric-Bernstam F, Kurzrock R. Phase I trial of paclitaxel, bevacizumab, and temsirolimus in advanced solid malignancies. J Clin Oncol, 2016 ASCO Annual Meeting 34(15 Suppl), 2016.
- Reilley M, Bailey AM, Subbiah V, Janku F, Naing A, Falchook GS, Karp DD, Piha-Paul Sa, Tsimberidou AM, Fu S, Zinner R, Lim J, Bean SA, Bass A, Montez S, Vence LM, Sharma P, Allison JP, Meric-Bernstam F, Hong DS. Phase I clinical trial of combination imatinib and ipilimumab in patients with advanced malignancies. J Clin Oncol, 2016 ASCO Annual Meeting 34(15 Suppl), 2016.
- Tsimberidou AM, Ou Y, Cutler R, Papadopoulos K, Sharma S, Gore L, Wang Z, Xu Y, Demirhan E, Wang Z, Harvey RD, Pinchansik D, Lee S, Pervan M. A phase 1 study of oprozomib to assess drug-drug interaction with midazolam in patients with advanced malignancies. Clinical Pharmacol Ther: ASCPT 2016 Annual Meeting 99(S1):s100, 2016. e-Pub 2016.
- Harvey RD, Gore L, Wang D, Mita A, Sharma S, Nemunaitis J, Papadopoulos K, Pinchasik D, Ou Y, Demirhan E, Cutler RE, Tsimberidou AM. A phase 1 study to assess food effect on oprozomib in patients with advanced malignancies. Clin Pharmacol Ther: ASCPT 2016 Annual Meeting 99(S1):s98, 2016. e-Pub 2016.
- George G, Iwuanyanwu EC, Anderson KO, Piha-Paul SA, Wheler JJ, Zinner R, Naing A, Tsimberidou AM, Janku F, Subbiah, Cleeland CS, Mendoza TR, Hong DS. Sleep quality and its association with fatigue, symptom burden, and mood in patients with advanced cancer in a phase 1 clinic. J Clin Oncol; 2015 ASCO Annual Meeting 33(15s), 2015.
- Kopetz S, Litzenburger B, Kinyua W, Sajan B, Subbiah S, Zinner R, Wheler JJ, Hong DS, Tsimberidou AM, Overman MJ, Pagliaro LC, Busaidy NL, Westin SN, Glisson BS, Heymach J, Meric-Bernstam F, Shaw KR, Lee JJ, Broaddus R. Prospective evaluation of a 409-gene next generation sequencing platform to facilitate genotype-matched clinical trial enrollment. J Clin Oncol; 2015 ASCO Annual Meeting 33(15s), 2015.
- Hong DS, Morris VK, El Osta BE, Fu S, Overman MJ, Piha-Paul SA, Subbiah V, Kee Bk, Tsimberidou AM, Zinner R, Fogelman DR, Bellido J, Shureiqi I, Meric-Bernstam F, Kopetz S. Phase Ib study of vemurafenib in combination with irinotecan and cetuximab in patients with BRAF-mutated metastatic colorectal cancer and advanced cancers. J Clin Oncol; 2015 ASCO Annual Meeting 33(15s), 2015.
- Mahalingam D, Patel MR, Sachdev JC, Hart LL, Halama N, Ramanathan RK, Sarantopoulos J, Liu X, Yazji S, Jaeger D, Adib DR, Kerschbaumer R, Tsimberidou AM. First-in-human, phase I study assessing imalumab (Bax69), a first-in-class anti-oxidized macrophage migration inhibitory factor (oxMIF) antibody in advanced solid tumors. J Clin Oncol; 2015 ASCO Annual Meeting 33(15s), 2015.
- Kato S, Fontes Jardim DL, Johnson FM, Subbiah V, Piha-Paul SA, Tsimberidou AM, Falchook GS, Karp DD, Wheler JJ, Zinner R, Janku F, Fu S, Dandu L, Browne E, Meric-Bernstam F, Hong Ds. Phase I study of combination of crizotinib (C) and dasatinib (D) in patients (pts) with advanced cancer. J Clin Oncol; 2015 ASCO Annual Meeting 33(15s), 2015.
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- Stephen B, Wheler JJ, Tsimberidou AM, Wen S, Naing A, Hong DS, Falchook GS, Piha-Paul SA, Fu S, Janku F, Moulder SL, Kurzrock R. Survival of 1,181 patients in a phase I clinic: The University of Texas M. D. Anderson Cancer Center experience. J Clin Oncol; 2011 ASCO Annual Meeting Proceedings 29(15S):172s, 2011.
- Kurzrock R, Patnaik A, Rosenstein L, fu S, Papadopoulos KP, Smith DA, Gonzales T, Tsimberidou AM, Mays TA, Cox DS, Hong DS, DeMarini DJ, Le NT, Morris SR, Tolcher AW. Phase I dose-escalation of the oral MEK1/2 inhibitor GSK1120212 (GSK212) dosed in combination with the oral AKT inhibitor GSK2141795 (GSK795). J Clin Oncol; 2011 ASCO Annual Meeting Proceedings 29(15_suppl):215s, 2011.
- Fok J, Kurzrock R, Tsimberidou AM, Wen S, Naing A, Hong DS, Janku F, Falchook GS, Piha-Paul SA, Katz R, Fu S, Moulder SL, Wheler JJ. An umbrella protocol for histology-independent, phase I modular study based on EGFR mutation status: using erlotinib alone or in combination with cetuximab, bortezomib, or dasatinib to overcome resistance. J Clin Oncol; 2011 ASCO Annual Meeting Proceedings 29(15S):174s, 2011.
- Janku F, Garrido-Laguna I, Wheler JJ, Hong DS, Naing A, Falchook GS, Fu S, Moulder SL, Luthra R, Lee JJ, Tsimberidou AM, Kurzrock R. Screening for PIK3CA mutations, PTEN loss and RAS/RAF mutations in early-phase protocols with PI3K/mTOR pathway inhibitors. J Clin Oncol; 2011 ASCO Annual Meeting Proceedings 29(15S):631s, 2011.
- Vining D, Tsimberidou AM, Wang J, Garg N. Multimedia structured reporting: a picture is worth a thousand words. American Journal of Roentgenology 196(5):Supplement A10-A13, 2011.
- Tsimberidou AM, Hong D, Wheler JJ, FU S, Piha-Paul S, Naing A, Falchook G, Luthra R, Iskander NG, Wen S, Kurzrock R. Profile-related evidence to determine individualized cancer therapy (PREDICT): Preliminary results of the personalized phase I clinical trials program at MD Anderson Cancer Center. Cancer Res 71(8 Suppl 1), 2011.
- Tsimberidou AM, Wierda WG, Wen S, Plunkett P, O'Brien S, Kipps TJ, Jones JA, Kantarjian HM, Keating MJ. Results of a phase I-II clinical trial of oxaliplatin, fludarabine, cytarabine, and rituximab (OFAR) combination therapy In patients with aggressive, relapsed/refractory chronic lymphocytic leukemia (CLL) and Richter syndrome (RS). Blood; 52nd ASH Annual Meeting Abstracts 116(21), 2010.
- Janku F, Tsimberidou AM, Garrido-laguna I, Hong DS, Naing A, Falchook GS, Fu S, Luthra R, Wang X, Kurzrock R. Screening for PIK3CA, RAS, and RAF mutations in trials with PI3K/AKT/MTOR signaling pathway inhibitors. EJC Supplements 8(7):83, 2010.
- Vaklavas C, Tsimberidou AM, Wen S, Fu S, Hong DS, Wheler J, Naing A, Uehara C, Wolff RA, Kurzrock R. Clinical outcomes and prognostic factors of hepatic arterial infusion (HAI) chemotherapy combination regimens in 202 patients with advanced cancer metastatic to the liver: The Phase I Program M. D. Anderson Cancer Center. J Clin Oncol; Proceedings of the 2010 ASCO Annual Meeting 28(15s), 2010.
- Janku, F, Tsimberidou AM, Garrido-Laguna I, Hong DS, Naing A, Falchook GS, Wheler JJ, Fu S, Piha-Paul SA, Kurzrock R. PIK3CA, KRAS and BRAF mutations in patients with advanced cancers treated with PI3K/AKT/mTor axis inhibitors. J Clin Oncol; Proceedings of the 2010 ASCO Annual Meeting 28(15S):224S, 2010.
- Cabanillas ME, Kurzrock R, Sherman SI, Tsimberidou AM, Waguespack S, Naing A, Busaidy N, Gagel R, Wright JJ, Hong DS,. Phase I trial of combination sorafenib and tipifarnib: the experience in advanced differentiated thyroid cancer (DTC) and medullary thyroid cancer (MTC). J Clin Oncol; Proceedings of the 2010 ASCO Annual Meeting 28s(15s):442s, 2010.
- Wheler JJ, Tsimberidou AM, Wen S, Naing A, Hong DS, Falchook GS, Piha-Paul SA, Fu S, Moulder SL, Kurzrock R. Toxicity in 1,181 patients with advanced solid tumors treated in phase I clinical trials of predominantly targeted agents: The M. D. Anderson Cancer Center experience. J Clin Oncol; Proceedings of the 2010 ASCO Annual Meeting 28(15s):230s, 2010.
- Stephen S, Naing A, Hong DS, Fu S, Wheler JJ, Moulder SL, Falchook GS, Tsimberidou AM, Piha-Paul SA, Kurzrock R. The use of complementary and alternative medicine in patients seen in phase I clinical trials program. J Clin Oncol; Proceedings of the 2010 ASCO Annual Meeting 28(15s):658s, 2010.
- Tsimberidou AM, Vaklavas C, Wen S, Hong D, Wheler J, Ng CS, Naing A, Uehara C, Wolff R, Kurzrock R. Clinical outcomes and prognostic factors in 83 patients with pancreatic cancer treated in phase I clinical trials at M.D. Anderson Cancer Center. Cancer Res; Proceedings of the AACR 101st Annual Meeting 2010 70(8 Suppl), 2010. e-Pub 2010.
- Wheler, J, Tsimberidou A, Moulder S, Cristofanilli M, Hong D, Naing A, Pathak R, Liu S, Kurzrock R. Clinical outcomes of patients with breast cancer in a phase I clinic: The M.D. Anderson Cancer Center experience. Clinical Breast Cancer; The 2009 San Antonio Breast Cancer Symposium 10(1), 2010.
- Tsimberidou AM, Wierda WG, Badoux X, Wen S, Plunkett W, O'Brien Sm, Kipps TJ, Jones JA, Kantarjian H, Keating MJ. Evaluation of oxaliplatin, fludarabine, cytarabine, and rituximab (OFAR) combination therapy in aggressive chronic lymphocytic leukemia (CLL) and Richter Syndrome (RS). J Clin Oncol; Proceedings of the 2010 ASCO Annual Meeting 28(15s):492s, 2010.
- Tsimberidou AM, Akerley W, Ng C, Hong D, Uehara C, Warren T, Yu, MK, Swabb EA, Kurzrock, R. Azixa a microtubule formation inhibitor in solid tumors: Results of a Phase 1 clinical trial. Cancer Res; Procedings of the 100th AACR Annual Meeting 69(9 Suppl), 2009.
- Tsimberidou AM, Hong D, Ng C, Wheler J, Naing A, Bedikian A, Eng C, Fortier A, Uehara C, Kurzrock R. A phase I study of hepatic arterial infusion of oxaliplatin in combination with systemic fluorouracil, leucovorin and bevacizumab in patients with advanced solid tumors metastatic to the liver. Cancer Res; Procedings of the 100th AACR Annual Meeting 69(9 Suppl), 2009.
- Tsimberidou AM, Wierda WG, Plunkett WK, O'Brien S, Lerner S, Smith, SC, Kantarjian HM, Keating, MJ. Phase I/II study of oxaliplatin, fludarabine, cytarabine, and rituximab in patients (OFAR2) with Richter's syndrome (RS), and relapsed or refractory B-cell chronic lymphocytic leukemia (CLL). J Clin Oncol; Proceedings of the 2009 ASCO Annual Meeting 27(15_Suppl):363s, 2009.
- Wheler J, Tsimberidou A, Moulder S, Cristofanilli M, Hong D, Naing A, Pathak R, Liu S, Kurzrock R. Clinical outcomes of patients with breast cancer in a phase I clinic: The M. D. Anderson Cancer Center experience. J Clin Oncol; Proceedings of the 2009 ASCO Annual Meeting 27(15_Suppl):54s, 2009.
- Ewald BJ, Sampath D, Zevevic A, Tsimberidou AM, Wierda WG, Plunkett W. Fludarabine and ara-C increase oxaliplatin-induced DNA damage and cytotoxicity in chronic lymphocytic leukemia. Cancer Res; Procedings of the 100th AACR Annual Meeting 69(9 Suppl), 2009.
- Tsimberidou AM, Wierda W, Plunkett W, O'Brien S, Kipps TJ, Jones J, Smith S, Jalayer A, Kantarjian HM, Keating M. Oxaliplatin, fludarabine, cytarabine, and rituximab induces high response rates in aggressive chronic lymphocytic leukemia (CLL) and Richter's syndrome (RS). Blood (ASH Annual Meeting) 114(22):3443, 2009.
- Tsimberidou AM, Wen S, O'Brien S , McLaughlin P , Wierda WG , Kantarjian H , Lerner S , Strom S , Freireich EJ, Medeiros L, Keating MJ. Other malignancies in chronic lymphocytic leukemia/small lymphocytic lymphoma: Analysis of 2028 patients. Annals of Oncology 19(Suppl 4), 2008.
- Wheler JJ, Tsimberidou AM, Hong DS, Jackson TL, Polk DY, Pilat S, Liu S, Feng L, Kurzrock R. Survival of patients in a phase I clinic: The M.D. Anderson Cancer Center experience. J Clin Oncol 26(15_suppl), 2008.
- Tsimberidou AM, Rudek M , Hong D. Ng C , Blair J , Goldsweig H , Kurzrock R. Phase 1 first-in-human study of s-trans, trans-farnesylthiosalicylic acid (salirasib) in patients with solid tumors. J Clin Oncol; Proceedings of the 2008 ASCO Annual Meeting 26(15_Suppl):593s, 2008.
- Tsimberidou AM, Estey E, Albitar M, Wen S, Brandt M, Pierce S, Kantarjian H, Kurzrock R,. Prognostic significance of tissue necrosis factor-alpha in newly diagnosed acute myeloid leukemia and high-risk myleodysplastic syndromes. Blood; Proceedings of the 2007 ASH Annual Meeting 110(11):133b, 2007.
- Tsimberidou AM, Kantarjian H, Faderl S, Pierce S, Freireich E, Estey E,. Untreated patients with acute myeloid leukemia, age 50-59 years and performance status 2 should be as eligible for targeted therapy as older patients. Blood; Proceedings of the 2007 ASH Annual Meeting 110(11):842a, 2007.
- Tsimberidou AM, Kantarjian H, Faderl S, Pierce S, Freireich E, Estey E.. Exclusion of acute myeloid leukemia (AML) clinical trials of patients unlikely to respond. Blood; Proceedings of the 2007 ASH Annual Meeting 110(11):843a, 2007.
- Tsimberidou AM, Hantarjian H, O'Brien S, Garcia-Manero G, Koller C, Jones D, Pierce S, Brandt M, Keating M, Estey E.. All-Trans Retinoic Acid (ATRA) and Arsenic Trioxide (As2O3) Combination Therapy Induces High Rates of Durable Molecular Remission in Newly Diagnosed Acute Promyelocytic Leukemia (APL). Blood; Proceedings from the 2007 ASH Annual Meeting 110(11):543a, 2007.
- Tam C, Keating M, Tsimberidou AM, O'Brien S, Ferrajoli A, Lerner S, Faderl S, Abruzzo L, Schlette E, Kantarjian H, Wierda W. The clinical usefulness of novel prognostic factors in CLL: A study of 477 patients with low-risk (non-11q non-17p) FISH and known IGVH mutation status. Blood; Proceedings of the 2007 ASH Annual Meeting 110(11), 2007.
- Tsimberidou AM, Tam C, Wierda WG, O'Brien S, Lerner S, Kantarjian HM, Keating MJ. The prognostic significance of 11q deletion detected by fluorescence in situ hybridization (FISH) in untreated chronic lymphocytic leukemia: The MDACC experience. Blood; Proceedings of the 2007 ASH Annual Meeting 110(11):619a, 2007.
- Tsimberidou AM, Tam C, Wierda W, O'Brien S, Lerner S, Keating M.. Beta-2 microglobulin (β2M) is an independent prognostic factor for clinical outcomes in patients with CLL treated with frontline fludarabine, cyclophosphamide, and rituximab regardless of age, creatinine clearance or performance status. J Clin Oncol; Proceedings of the 2007 ASCO Annual Meeting 25(Suppl 18), 2007.
- Tsimberidou AM, Kantarjian HM, Wen S, Keating MJ, O'Brien S, Cortes J, Pierce S, Brandt M, Freireich E, Estey E.. Prognostic score including serum β2 microglobulin levels to stratify patients with acute myeloid leukemia: analysis of 1,293 patients. Haematologica; Proceedings of the 12th Congress of The European Hematology Association 92(Suppl 1):22, 2007.
- Tsimberidou AM, Wierda W, O'Brien S, Wen S, Plunkett W, Kipps T, Lerner S, Kantarjian H, Freireich E, Keating M.. Comparison of oxaliplatin, fludarabine, cytarabine, and rituximab therapy with cyclophosphamide, vincristine, liposomal daunorubicin, dexamethasone, rituximab and GM-CSF alternating with methotrexate, cytarabine, rituximab GM-CSF therapy: Analysis of 53 patients with Richter's syndrome. XII International Workshop on CLL, London, UK ( Supplement 1 to Leukemia and Lymphoma) 48:S170, 2007.
- Tsimberidou AM, Kantarjian HM, Garcia-Manero G, Koller C, Jones DM, Keating MJ, Estey E.. Clinical outcomes and rates of molecular remission with all-trans retinoic acid and arsenic trioxide combination therapy in newly diagnosed acute promyelocytic leukemia. J Clin Oncol; Proceedings of the 2006 ASCO Annual Meeting 24(18_suppl):337s, 2006.
- Garcia M, Deavers MT, Knoblock RJ, Chen W, Tsimberidou AM, Manning JM, Medeiros LJ.. Myeloid sarcoma involving the gynecologic tract. A report of 11 cases and review of the literature. Proceedings of the United States and Canadian Academy of Pathology Annual Meeting, Atlanta, Georgia, 2006.
- Tsimberidou AM, Kantarjian HM, Keating MJ, O'Brien S, Wen S, Cortes J, Giles F, Koller CA, Garcia-Manero G, Pierce S, Brandt M, Freireich EJ, Estey EH.. Prognostic significance of β-2 microglobulin levels in acute myeloid leukemia: analysis of 1293 patients. Blood; Proceedings of the 2006 ASH Annual Meeting 108(11):240a, 2006.
- Tsimberidou AM, Keating MJ, Kantarjian H, O'Brien S, Cortes J, Koller C, Pierce S, Brandt M, Beran M, Estey E.. Granulocytic sarcoma is associated with event-free survival superior to that of acute myeloid leukemia. Blood; Proceedings of the 2006 ASH Annual Meeting 108(11):568a, 2006.
- Tsimberidou AM, O'Brien S, McLaughlin P, Wen S, Wierda W, Kantarjian H, Manning H, Lerner S, Hess M, Freireich EJ, Keating MJ.. Other malignancies in chronic lymphocytic leukemia/small lymphocytic lymphoma: analysis of 2083 patients. Blood; Proceedings of the 2006 ASH Annual Meeting 108(11):790a, 2006.
- Tsimberidou AM, Werida W, O'Brien S, Plunkett W, Kipps T, Brown J, Lerner S, Kantarjian H, Keating MJ.. Combination of oxaliplatin, fludarabine, cytarabine, and rituximab in patients with Richter's syndrome and fludarabine-refractory chronic lymphocytic leukemia. Blood; Proceedings of the 2006 ASH Annual Meeting 108(11):799a, 2006.
- Tsimberidou AM, McLaughlin P, O'Brien S, Wen S, Wierda W, Manning J, Lerner S, Hess M, Kantarjian H, Freireich E, Keating MJ.. A prognostic score for chronic lymphocytic leukemia and small lymphocytic lymphoma: analysis of 2189 patients. Blood; Proceedings of the 2006 ASH Annual Meeting 108(11):788a, 2006.
- Tsimberidou AM. Genomic aberrations in chronic lymphocytic leukemia and small lymphocytic lymphoma by absolute analysis of 1694 patients. Blood; Proceedings of the 2006 ASH Annual Meeting 108(11):327b, 2006.
- Tsimberidou AM. Outcome in patients with Richter's syndrome treated with chemotherapy and/or immunotherapy with or without stem cell transplantation. Blood; Proceedings of the Third Annual Conference on Therapeutic Advances in the Treatment of Hematological Malignancies 106(11), 2005.
- Tsimberidou AM, O'Brien S, Wierda WG, Garcia-Manero G, Lerner S, Keating MJ. Effects of immunotherapy on survival and progression-free survival in patients with splenic marginal zone lymphoma or marginal zone leukemia/lymphoma. Proceedings of the American Society of Clinical Oncology 23:5805, 2005.
- Tsimberidou AM, O'Brien S, Wierda WG, Garcia-Manero G, Lerner S, Keating MJ. A comparison of outcomes in patients with splenic marginal zone lymphoma or marginal zone leukemia/lymphoma treated with immunotherapy, chemoimmunotherapy, or chemotherapy. Ann Oncol: Ninth International Conference on Malignant Lymphoma, Lugano 16(Suppl 5):v124, 2005.
- Tsimberidou AM, Catovsky D, Schlette E, O'Brien S, Wierda W, Garcia-Manero G, Lerner S, Keating MJ.. Rituximab with or without chemotherapy is associated with prolonged survival in patients with splenic marginal zone lymphoma or marginal zone leukemia/lymphoma. XI International Workshop on CLL, New York, NY 46(Suppl 1):91, 2005.
- Tsimberidou AM, Keating M, McLaughlin P, O'Brien S, Wierda W, Ferrajoli A, Manning J, Kantarjian H.. Comparison of small lymphocytic lymphoma with chronic lymphocytic leukemia. The M. D. Anderson Cancer Center experience. Blood 106(11):270a, 2005.
- Tsimberidou AM, Catovsky D, Schlette E, O'Brien S, Kantarjian H. Wierda W, Smith S, Wen S, Lerner S, Keating M.. Outcomes in patients with splenic marginal zone lymphoma or marginal zone leukemia/lymphoma treated with immunotherapy, chemoimmunotherapy, or chemotherapy. Blood 106(11):270a, 2005.
- Tsimberidou AM, O'Brien S, Kantarjian H, Koller C, Hagemeister F, Fayad L, Lerner S, Keating M.. Transformation of chronic lymphocytic leukemia in Hodgkin's disease. The M. D. Anderson Cancer Center experience. Blood 106(11):287a, 2005.
- Tsimberidou AM, O'Brien S, Khouri I, Giles F, Kantarjian H, Wen S, Smith S, Lerner S, Freireich E, Keating M.. Clinical outcomes and prognostic factors in patients with Richter's syndrome treated with chemotherapy and/or immunotherapy with or without stem cell transplantation. Blood 106(11):593a, 2005.
- Tsimberidou AM Keating M, Bueso-Ramos C, Kurzrock R.. Epstein-Barr virus in patients with chronic lymphocytic leukemia. Blood 106(11):598a, 2005.
- Keating MJ, McLaughlin P, Tsimberidou AM, O'Brien S.. Are chronic lymphocytic leukemia and small lymphocytic lymphoma the same disease?. IX International Conference on Malignant Lymhoma, Lugano, Switzerland 16(Suppl 5):v46, 2005.
- Kurzrock R, Khouri I, Bueso-Ramos C, Giles F, Pilat S, Thomas DA, Cortes J, Tsimberidou AM. Low-dose interleukin-11 has activity in patients with bone marrow failure. J Clin Oncol: Proceedings of the ASCO Annual Meeting 2004 23:172, 2004.
- Tsimberidou AM, Tirado-Gomez M, Andreeff M, O'Brien S, Kantarjian HM, Keating MJ, Lopez-Berestein G, Estey E.. Single agent liposomal-encapsulated (Lipo) all-trans retinoic acid (ATRA) can cure patients with untreated acute promyelocytic leukemia (APL): an update and comparison with an ATRA+idarubicin induction regimen. J Clin Oncol: Proceedings of the ASCO Annual Meeting 2004 23:559, 2004.
- Tsimberidou AM, Estey E, Cortes J, Verstovsek S, Faderl S, Thomas D, Wierda W, Garcia Manero G, Kantarjian H, Giles FJ.. Randomized comparison of idarubicin and cytarabine +/- interleukin in patients with newly diagnosed acute myelogenous leukemia or high-risk myelodysplastic syndrome. J Clin Oncol: Proceedings of the ASCO Annual Meeting 2003 21:585, 2003.
- Kurzrock R, Tsimberidou AM, Giles FJ, Duvic M.. Pilot study of recombinant human soluble tumor necrosis factor receptor (P75) fusion protein etanercept in patients with relapsed cutaneous T-cell lymphomas. J Clin Oncol: Proceedings of the ASCO Annual Meeting 2003 21:590, 2003.
- Alvarado Y, Kantarjian H, Cortes J, Verstovsek S, Faderl S, Garcia-Manero G, Tsimberidou A, Sznol M, Giles F. Phase I study of VNP4010M, a novel alkylating agent in patients with refractory hematologic malignancies. J Clin Oncol: Proceedings of the ASCO Annual Meeting 2003 21:585, 2003.
- Tsimberidou AM, Giles FJ, Duvic M, Fayad L, Kurzrock R.. Phase II study of pentostatin in patients with T-cell lymphomas: update of an M. D. Anderson Cancer Center series. Blood 102(11):639a, 2003.
- Tsimberidou AM, Giles FJ, Duvic M, Fayad L, Kurzrock R.. Activity of interferon-alpha and isotretinoin in patients with advanced, refractory lymphoid malignancies. Blood 102(11):649a, 2003.
- Tsimberidou AM, Keating MJ, Giles F, Lerner S, Kantarjian H, O'Brien S.. Phase II study of fludarabine and mitoxantrone in patients with chronic lymphocytic leukemia. Blood 102(11):358b, 2003.
- Giles FJ, List AF, Roboz GJ, Tsimberidou AM, Laurent D, Reitsma D, Kowalski M, Kantarjian H, Feldman EJ.. Phase I/II study of PTK787/ZK222584 (PTK/ZK), a novel, oral VEGF-receptor inhibitor, in patients with myelofibrosis with myeloid metaphasia. Blood 102(11):922a, 2003.
- Liu Q, Fayad L, Romaguera J, Hagemeister FB, Rodriguez MA, Younes A, Pro B, Verstovsek S, Cabanillas F, Tsimberidou A, Hess M, Ayala A, Clemons M, McLaughlin P.. Stage IV indolent lymphoma: 25 years of treatment progress. Blood 102(11):398a, 2003.
- Giles F, Kantarjian H, Cortes J, Tsimberidou AM, Faderl S, Verstovsek S, Thomas D, Garcia-Manero G, Wierda W, Ferrajoli A, Kornblau S, Andreeff M, O'Brien S, Beran M, Estey E.. Adaptive randomized study of idarubicin and cytarabine alone or with interleukin-11 as induction therapy in patients aged 50 or above with untreated acute myeloid leukemia or high-risk myelodysplastic syndromes. Blood 102(11):253b, 2003.
- Apostolidou E, Cortes J, Tsimberidou AM, Estey E, Kantarjian H, Giles F. Mylotarg, liposomal daunorubicin, Ara-C and cyclosporine regimen in patients with relapsed/refractory acute myelogenous leukemia. Blood 100(11):268b, 2002.
- Giles FJ, Tsimberidou AM, Dabaja B, Kantarjian H, Keating M, O'Brien S. Alternating cyclophosphamide, vincristine, liposomal daunorubicin, and dexamethasone / methotrexate, and ara-C with rituximab and GM-CSF in patients with relapsed / refractory chronic lymphocytic leukemia. Proceedings of the IX International Workshop on CLL, San Diego, California, 2002.
- Tsimberidou AM, Estey E, Cortes J, Thomas D, Garcia-Manero G, Faderl S, Verstovsek S, O'Brien S, Kantarjian H, Giles F. Adaptive randomization of idarubicin and Ara-C ± interleukin in patients with newly diagnosed acute myelogenous leukemia or high-risk myelodysplastic syndrome. Blood 100(11):264b, 2002.
- Tsimberidou AM, Estey E, Cortes J, Thomas D, Garcia-Manero G, Faderl S, Verstovsek S, Beran M, Keating M, O'Brien S, Kantarjian H, Giles F. Nonleukemic granulocytic sarcoma in a single institution: frequency, presentation and clinical outcome. Blood 100(11):243b, 2002.
- Tsimberidou AM, Estey E, Cortes J, Thomas D, Garcia-Manero G, Faderl S, Verstovsek S, O'Brien S, Kantarjian H, Giles F. Feasibility of mylotarg, fludarabine, Ara-c and cyclosporine regimen as post-remission therapy in acute myelogenous leukemia. Blood 100(11):339a, 2002.
- Tsimberidou AM, Estey E, Cortes J, Thomas D, Garcia-Manero G, Faderl S, Verstovesk S, O'Brien S, Kantarjian H, Giles H. Mylotarg, fludarabine, cytarabine and cyclosporine combination regimen in patients with CD33-positive primary resistant or relapsed acute myeloid leukemia. Blood 100(11):339a-340a, 2002.
- Tsimberidou AM, Estey E, Cortes J, Thomas D, Garcia-Manero G, Faderl S, Verstovsek S, O'Brien S, Kantarjian H, Giles F.. Mylotarg, fludarabine, cytarabine and cyclosporine in patients with newly diagnosed acute myelogenous leukemia or high-risk myelodysplastic syndrome. Blood 100(11):339a, 2002.
- Tsimberidou AM, McLaughlin P, Feng L, Ayala A, Younes A, Rodriguez MA, Romaguera J, Hagemeister FB, Smith TL, Cabanillas F. Duration of decreased absolute number of circulating CD4 cells and CD4/CD8 ratio in patients with indolent lymphoma treated with fludarabine. Blood 100(11):775a, 2002.
- Tsimberidou AM, Stavroyanni N, Viniou N, Tiniakou M, Papaioannou M, Marinakis T, Papadopoulos A, Papadaki HA, Megalakaki C, Sakellari I, Skandali A, Panagiotidis P, Matsouka P, Rombos Y, Yataganas X. Comparison of allogeneic stem cell transplantation, high-dose cytarabine, and autologous peripheral blood stem cell transplantation as post-remission treatment in patients with de novo acute myelogenous leukemia. Blood 100(11):861a, 2002.
- Tsimberidou AM, Waddelow T, Xiao QD, Albitar M, Giles FJ. Increase in plasma TNF-α levels during enbrel treatment of patients with refractory multiple myeloma. J Clin Oncol: Proceedings of ASCO Annual Meeting 2002:276a, 2002.
- Tsimberidou AM, Tsionos K, Lee MS, Ford R, Lichtiger B, Luthra R, McLaughlin P, Medeiros LJ, Cabanillas F, Sarris AH. Quantitation of circulating cells bearing the t(14;18) in normal donors and patients with lymphoma. J Clin Oncol: Proceedings of the ASCO Annual Meeting 2000:15a, 2000.
Book Chapters
- Said R, Nickolich M, Lenihan DJ, Tsimberidou AM. Cardiotoxicity of anticancer therapies. In: Cardio-Oncology: The Clinical Overlap of Cancer and Heart Disease. Springer: Switzerland, 2017.
- Tsimberidou AM. Targeted therapies in cancer. In: MD Anderson Manual of Medical Oncology. 3rd ed. McGraw-Hill Education: New York, United States, 1003-1019, 2016.
- Said R, Tsimberidou AM. Future perspectives. In: Targeted Therapy in Translational Cancer Research. Wiley Blackwell: New Jersey, United States, 363-70, 2015.
- Tsimberidou AM, Keating, MJ. Chronic lymphocytic leukemia (CLL) /small lymphocytic lymphoma (SLL). In: 60 Years of Survival Outcomes at UTMDACC. Springer: New York, NY, 211-223, 2013.
- Tsimberidou AM, Keating MJ. Targeted therapy in chronic lymphocytic leukemia. In: Targeted Cancer Therapy. Humana Press: New York, 61-86, 2008.
- Tsimberidou AM, Keating MJ. Hyperuricemic syndromes in cancer patients. In: Hyperuricemic Syndromes: Pathophysiology and Therapy. S. Karger, AG Basel, 47-60, 2005.
- Tsimberidou AM, Jiang YF, Ford R, Cabanillas F, Sarris AH. Real-time polymerase chain reaction of genomic DNA for quantitation of t(14;18). In: Detection of minimal residual disease in hematologic malignancies by Zipf and Johnston. Humana Press: New York, 223-236, 2002.
Books (edited and written)
- Tsimberidou AM, Kurzrock R, Anderson KC. Targeted Therapy in Translational Cancer Research. In: Translational oncology. 1st. Wiley-Blackwell: New Jersey, United States, 2016.