Bin Wang, Ph.D.
Department of Genetics, Division of VP, Research
About Dr. Wang
Dr. Wang is a Professor in the Department of Genetics. Her research is focused on understanding how cells respond to DNA damage and safeguard the integrity of the genome. Her laboratory takes multidisciplinary approach to identify important players in the DNA damage response and define the roles of these genes in maintaining genomic stability and tumor suppression.
View a compelte list of Dr. Wang's publications.
Visit Dr. Wang's Lab website.
Present Title & Affiliation
Professor, Department of Genetics, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX
A hallmark of cancer is genomic instability. Defects in the ability of cells to properly respond to and repair DNA damage result in genomic instability and underlie many forms of cancer. The goal of our research is to understand how cells respond to DNA damage and safeguard the integrity of the genome. We use functional and molecular approaches that involve imaging, CRISPR/Cas9 gene editing, genetics screens, high throughput sequencing, mass spectrometry, mouse model, etc.
(1) How does the hereditary breast tumor suppressor BRCA1 interaction network suppress breast tumor development? ( Castillo et al, Cell Rep 8, 807-817, 2014; Wu et al, Mol Cell 61, 434-448, 2016 );
(2) How does chromatin modification at sites of DNA damage regulate DNA repair and transcription? ( Paul and Wang, Mol Cell 66, 458-472, 2017; Wu et al, Genes Dev 33, 1702-1717, 2019 );
(3) How does the cell protect genome stability in response to DNA replication stress? ( Xu et al, Genes Dev 31, 1469-1482, 2017 ) Visit Dr. Wang's lab website. View a complete list of Dr. Wang's publications.https://mdanderson.elsevierpure.com/en/persons/bin-wang
Education & Training
|2000||Baylor College of Medicine, Houston, TX, USA, PHD, Biochemistry and Molecular Biology|
|1994||Shanghai Institute of Biochemistry, Shanghai, CHN, MS, Molecular Biology|
|1991||Nanjing University, Nanjing, CHN, BS, Biochemistry|
|2003-2008||Postdoctoral Fellow, Brigham and Women's Hospital/Harvard Medical School, Boston, MA|
|2000-2003||Postdoctoral Fellow, Baylor College of Medicine, Houston, TX|
Experience & Service
Assistant Professor, Department of Genetics, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 2008 - 2014
Assistant Professor, UTMD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences, Houston, TX, 2008 - 2014
- 2. Zu Y, Xu S, Shi Y, Bacolla A, Syed A, Moiani, D, Shen C, Peng G, Leonard PG, Jones DE, Wang B, Tainer JA, Ahmed Z.. GRB2 enforces homology-directed repair initiation by MRE11. Sci Adv 7(32):eabe9254, 2021. PMID: 34348893.
- Wu X and Wang B. Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage. Nat Commun 12(1):4373, 2021. e-Pub 2021. PMID: 34272385.
- Yamaguchi H, Kitami K, Wu X, He L, Wang J, Wang B, Komatsu Y. Alteration of DNA Damage Response Causes Cleft Palate. Front Physiol 12:649492, 2021. PMID: 33854442.
- Zhang P, Yao J, Wang B, Qin L. Microfluidics-Based Single-Cell Protrusion Analysis for Screening Drugs Targeting Subcellular Mitochondrial Trafficking in Cancer Progression. Anal Chem 92(4):3095-3102, 2020. e-Pub 2020. PMID: 31965790.
- Chu YY, Yam C, Chen MK, Chan LC, Xiao M, Wei YK, Yamaguchi H, Lee PC, Han Y, Nie L, Sun X, Moulder SL, Hess KR, Wang B, Hsu JL, Hortobagyi GN, Litton J, Chang JT, Hung MC. Blocking c-Met and EGFR reverses acquired resistance of PARP inhibitors in triple-negative breast cancer. Am J Cancer Res 10(2):648-661, 2020. e-Pub 2020. PMID: 32195033.
- Wu X, Liu S, Sagum C, Chen J, Singh R, Chaturevedi A, Horton JR, Cheng X, Bedford MT and Wang B. Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne. Genes Dev 33:1702-1717, 2019. PMID: 31699778.
- Zhang P, Han X, Yao J, Shao N, Zhang K, Zhou Y, Zu Y, Wang B*, Qin L*. High-Throughput Isolation of Cell Protrusions with Single-Cell Precision for Profiling Subcellular Gene Expression. *Co-corresponding authors. Angew Chem. e-Pub 2019. PMID: 31188523.
- Kitami K, Kitami M, Kaku M, Wang B and Komatsu Y. BRCA1 and BRCA2 tumor suppressors in neural crest cells are essential for craniofacial bone development. PLOS Genetics 14(5):1007340, 2018.
- Zhang H, Li HS, Hillmer EJ, Zhao Y, Chrisikos TT, Hu H, Wu X, Thompson EJ, Clise-Dwyer K, Millerchip KA, Wei Y, Puebla-Osorio N, Kaushik S, Santos MA, Wang B, Garcia-Manero G, Wang J, Sun S-C, and Watowich SS.. Genetic rescue of lineage-balanced blood cell production reveals a crucial role for STAT3 antiinflammatory activity in hematopoiesis. Proc Natl Acad Sci USA 115(10):2311-2319, 2018. e-Pub 2018.
- Xu S, Wu X, Wu L, Castillo A, Liu J, Atkinson E, Paul A, Su D, Schlacher K, Komatsu Y, You MJ, Wang B. Abro1 maintains genome stability and limits replication stress by protecting replication fork stability. Genes Dev 31(14):1469-1482, 2017. PMID: 28860160.
- Paul A, Wang B. RNF8- and Ube2S-Dependent Ubiquitin Lysine 11-Linkage Modification in Response to DNA Damage. Mol Cell 66(4):458-472, 2017. PMID: 28525740.
- Wu Q, Paul A, Su D, Mehmood S, Foo TK, Ochi T, Bunting EL, Xia B, Robinson CV, Wang B*, Blunder TL*. Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites. *Co-corresponding authors. Mol Cell 61(3):434-48, 2016. e-Pub 2016. PMID: 26778126.
- Ling H, Hu X, Li S, Qiao F, Yao L, Cao Z, Li K, Ye F, Wang B*, Shao Z*. Evaluation of BRCA1 associated A complex with triple negative breast cancer susceptibility in Chinese women. *Co-corresponding authors. Oncotarget 7(9):9759-72, 2016.
- Castillo A, Paul A, Sun B, Huang TH, Wang Y, Yazinski SA, Tyler J, Li L, You MJ, Zou L, Yao J, Wang B. The BRCA1-Interacting Protein Abraxas Is Required for Genomic Stability and Tumor Suppression. Cell Rep 8(3):807-17, 2014. e-Pub 2014. PMID: 25066119.
- Desai S, Ding M, Wang B, Lu Z, Zhao Q, Shaw K, Yung WKA, Weinstein, Tan M, Yao J.. Tissue-specific isoform switch and DNA hypomethylation of the PKM2 gene in human cancer. Oncotarget 5(18):8202-10, 2013. e-Pub 2013.
- Tian F, Sharma S, Zou J, Lin SY, Wang B, Rezvani K, Wang H, Parvin JD, Ludwig T, Canman CE, Zhang D. BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade. Proc Natl Acad Sci U S A 110(33):13558-63, 2013. e-Pub 2013. PMID: 23901102.
- Hu X, Paul A, Wang B. Rap80 protein recruitment to DNA double-strand breaks requires binding to both small ubiquitin-like modifier (SUMO) and ubiquitin conjugates. J Biol Chem 287(30):25510-9, 2012. e-Pub 2012. PMID: 22689573.
- Hu X, Kim JA, Castillo A, Huang M, Liu J, Wang B. NBA1/Merit40 and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36 containing complexes. J Biol Chem 286(13):11734-45, 2011. e-Pub 2011. PMID: 21282113.
- Wang B, Hurov K, Hofmann K, Elledge SJ. NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. Genes Dev 23(6):729-39, 2009. PMID: 19261749.
- Xiao A, Li H, Schecter D, Ahn SH, Fabrizio LA, Erdjument-Bromage H, Ishibe-Murakami S, Wang B, Tempst P, Hofmann K, Patel DJ, Elledge SJ, Allis CD. WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature 457(7225):57-62, 2009. e-Pub 2008. PMID: 19092802.
- Wang B, Elledge SJ. Ubc 13/Rnf8 ubiquitin ligase controls foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc Natl Acad Sci U S A 104(52):20759-63, 2007. e-Pub 2007. PMID: 18077395.
- Wang B, Matsuoka S, Ballif BA, Zhang D, Smogorzewska A, Gygi S, Elledge SJ. Abraxas and Rap80 form a BRCA1 protein complex required for the DNA damage response. Science 316(5828):1194-8, 2007. PMID: 17525340.
- Adams MM, Wang B, Xia Z, Morales JC, Lu X, Donehower LA, Bochar DA, Elledge SJ, Carpenter PB. 53BP1 oligomerization is independent of its methylation by PRMT1. Cell Cycle 4(12):1854-61, 2005. PMID: 16294047.
- Morales JC, Xia Z, Lu T, Aldrich MB, Wang B, Rosales C, Kellems RE, Hittelman WN, Elledge SJ, Carpenter PB. Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability. J Biol Chem 278(17):14971-7, 2003. PMID: 12578828.
- Stewart G, Wang B, Bignell CR, Taylor AM, Elledge SJ. MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature 421(6926):961-6, 2003. PMID: 12607005.
- Wang B, Matsuoka S, Carpenter PB, Elledge SJ. 53BP1 a mediator of the DNA damage checkpoint. Science 298(5597):1435-8, 2002. PMID: 12364621.
- Wang B, Kuspa A. CulB, a putative ubiquitin ligase subunit, regulates prestalk cell differentiation and morphogenesis in Dictyostelium spp. Eukaryotic Cell 1(1):126-36, 2002. PMID: 12455979.
- Wang B, Shaulsky G, Kuspa A. Multiple developmental roles for CRAC, a cytosolic regulator of adenylyl cyclase. Dev Biol 208(1):1-13, 1999. PMID: 10075837.
- Wang B, Kuspa A. Dictyostelium development in the absence of cAMP. Science 277:251-4, 1997. PMID: 9211856.
- Wang B. BRCA1 Tumor Suppressor Network: Focusing on Its Tail. Cell & Bioscience 2:6, 2012.
- Wang B. Ubiquitin modification in DNA damage response. Fusion Conferences, 4th DNA repair/replication structures and cancer conference, 2020.
- Wang B. Ubiquitin signaling in DNA damage response. The 10th International Symposium on DNA Damage Response & Human Disease, 2019.
- Wu X, Liu S, Sagum C, Chen J, Singh R, Chaturvedi A, Horton JR, Cheng X, Bedford MT and Wang B. Ubiquitin signaling at DNA double strand breaks. Fusion Conferences, "Exploring DNA repair pathways as targets for cancer therapy", 2019.
Grant & Contract Support
|Title:||The role of a BRCA1-associated complex in DNA damage response and tumor suppression|
|Title:||Characterizing Abrol in protection of stalled replication fork integrity and tumor suppression|
|Funding Source:||MDACC IRG|
|Title:||Functional analysis of linage-specific ubiquitin modification at double strand breaks|
|Funding Source:||Cancer Prevention & Research Institute of Texas (CPRIT)|
|Title:||Defining protective responses in hematopoietic cells mediated by STAT3-inflammatory activity|
|Title:||Coordination of DNA repair and transcription by ubiquitin modification|