Bin Wang, Ph.D.
Department of Genetics, Division of Discovery Science
About Dr. Bin Wang
Dr. Wang is a Professor in the Department of Genetics. Her research is focused on understanding how cells respond to DNA damage and safeguard the integrity of the genome. Her laboratory takes multidisciplinary approach to identify important players in the DNA damage response and define the roles of these genes in maintaining genomic stability and tumor suppression.
View a compelte list of Dr. Wang's publications.
Visit Dr. Wang's Lab website.
Present Title & Affiliation
Primary Appointment
Professor, Division of Discovery Science, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX
Professor, Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Professor, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX
Professor, Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
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A hallmark of cancer is genomic instability. Defects in the ability of cells to properly respond to and repair DNA damage result in genomic instability and underlie many forms of cancer. The goal of our research is to understand how cells respond to DNA damage and safeguard the integrity of the genome. We use functional and molecular approaches that involve imaging, CRISPR/Cas9 gene editing, genetics screens, high throughput sequencing, mass spectrometry, mouse model, etc.
Ongoing Projects:
(1) How does the hereditary breast tumor suppressor BRCA1 interaction network suppress breast tumor development? (Castillo et al, Cell Rep 8, 807-817, 2014; Wu et al, Mol Cell 61, 434-448, 2016);
(2) How does chromatin modification at sites of DNA damage regulate DNA repair and transcription? (Paul and Wang, Mol Cell 66, 458-472, 2017; Wu et al, Genes Dev 33, 1702-1717, 2019);
(3) How does the cell protect genome stability in response to DNA replication stress? (Xu et al, Genes Dev 31, 1469-1482, 2017)
https://mdanderson.elsevierpure.com/en/persons/bin-wang
Visit Dr. Wang's lab website.
View a complete list of Dr. Wang's publications.
Education & Training
Degree-Granting Education
| 2000 | Baylor College of Medicine, Houston, Texas, US, Biochemistry and Molecular Biology, Ph.D |
| 1994 | Shanghai Institute of Biochemistry, Shanghai, CN, Molecular Biology, M.S |
| 1991 | Nanjing University, Nanjing, CN, Biochemistry, BS |
Postgraduate Training
| 2003-2008 | Postdoctoral Fellow, Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts |
| 2000-2003 | Postdoctoral Fellow, Baylor College of Medicine, Houston, Texas |
Experience & Service
Faculty Academic Appointments
Associate Professor, UTMD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences, Houston, TX, 2014 - 2022
Associate Professor, Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2014 - 2022
Assistant Professor, UTMD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences, Houston, TX, 2008 - 2014
Assistant Professor, Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2008 - 2014
Other Professional Positions
Member, The University of Texas MD Anderson Cancer Center, Center for Genetics and Genomics, Houston, TX, 2009 - 2017
Member, The University of Texas MD Anderson Cancer Center, Center for Cancer Epigenetics, Houston, TX, 2009 - 2017
Honors & Awards
| 2023 - 2025 | Faculty Senate, MD Anderson Cancer Center |
| 2016 | Provost's Wall of Science, MD Anderson Cancer Center |
| 2016 | GSBS Faculty Recognition Award, GSBS |
| 2009 - 2011 | Sidney Kimmel Scholar, Sidney Kimmel Foundation for Cancer Research |
| 2005 - 2010 | Howard Temin Award, National Institute of Health, National Cancer Institute |
| 2002 - 2005 | Postdoctoral Fellowship, US Army Breast Cancer Foundation |
| 1999 | Annual Graduate Student Symposium platform presentation speaker, Baylor College of Medicine Graduate School of Biomedical Sciences |
Selected Publications
Peer-Reviewed Articles
- Wang, L, Wu, X, Paul, A, Yao, J, Wang, B. The deubiquitinating enzyme Cezanne stabilizes BRCA1 by counteracting APC/C and Ube2Sdependent Lys11-linked ubiquitination. PLoS biology 23(12), 2025. e-Pub 2025. PMID: 41359628.
- Ye, Z, Xu, S, Shi, Y, Cheng, X, Zhang, Y, Roy, S, Namjoshi, S, Longo, M, Link, T, Schlacher, K, Peng, G, Yu, D, Wang, B, Tainer, J, Ahmed, Z. GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer. Nature Commun 15(1):2132, 2024. e-Pub 2024. PMID: 38459011.
- Liu S, Atkinson E, Paulucci-Holthauzen A, Wang B. A CK2 and SUMO-dependent, PML NB-involved regulatory mechanism controlling BLM ubiquitination and G quadruplex resolution. Nature Commun 14(1):6111, 2023. e-Pub 2023. PMID: 37777511.
- Shao, N, Zhou, Y, Yao, J, Zhang, P, Song, Y, Zhang, K, Han, X, Wang, B, Liu, X. A Bidirectional Single-Cell Migration and Retrieval Chip for Quantitative Study of Dendritic Cell Migration. Advanced Science 10(8), 2023. e-Pub 2023. PMID: 36658690.
- Emam A, Wu X, Xu S, Wang L, Liu S, Wang B. Stalled replication fork protection limits cGAS-STING and P-body-dependent innate immune signalling. Nat Cell Biol 24(7):1154-1164, 2022. e-Pub 2022. PMID: 35817959.
- Zu Y, Xu S, Shi Y, Bacolla A, Syed A, Moiani, D, Shen C, Peng G, Leonard PG, Jones DE, Wang B, Tainer JA, Ahmed Z. GRB2 enforces homology-directed repair initiation by MRE11. Sci Adv 7(32):eabe9254, 2021. e-Pub 2021. PMID: 34348893.
- Wu X, Wang B. Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage. Nat Commun 12(1):4373, 2021. e-Pub 2021. PMID: 34272385.
- Yamaguchi H, Kitami K, Wu X, He L, Wang J, Wang B, Komatsu Y. Alteration of DNA Damage Response Causes Cleft Palate. Front Physiol 12:649492, 2021. e-Pub 2021. PMID: 33854442.
- Zhang P, Yao J, Wang B, Qin L. Microfluidics-Based Single-Cell Protrusion Analysis for Screening Drugs Targeting Subcellular Mitochondrial Trafficking in Cancer Progression. Anal Chem 92(4):3095-3102, 2020. e-Pub 2020. PMID: 31965790.
- Chu YY, Yam C, Chen MK, Chan LC, Xiao M, Wei YK, Yamaguchi H, Lee PC, Han Y, Nie L, Sun X, Moulder SL, Hess KR, Wang B, Hsu JL, Hortobagyi GN, Litton J, Chang JT, Hung MC. Blocking c-Met and EGFR reverses acquired resistance of PARP inhibitors in triple-negative breast cancer. Am J Cancer Res 10(2):648-661, 2020. e-Pub 2020. PMID: 32195033.
- Wu X, Liu S, Sagum C, Chen J, Singh R, Chaturevedi A, Horton JR, Cheng X, Bedford MT, Wang B. Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne. *Co-corresponding author. Genes Dev 33:1702-1717, 2019. e-Pub 2019. PMID: 31699778.
- Zhang P, Han X, Yao J, Shao N, Zhang K, Zhou Y, Zu Y, Wang B, Qin L. High-Throughput Isolation of Cell Protrusions with Single-Cell Precision for Profiling Subcellular Gene Expression. *Co-corresponding authors. Angew Chem, 2019. e-Pub 2019. PMID: 31188523.
- Kitami K, Kitami M, Kaku M, Wang B, Komatsu Y. BRCA1 and BRCA2 tumor suppressors in neural crest cells are essential for craniofacial bone development. PLOS Genetics 14(5):1007340, 2018. e-Pub 2018.
- Zhang H, Li HS, Hillmer EJ, Zhao Y, Chrisikos TT, Hu H, Wu X, Thompson EJ, Clise-Dwyer K, Millerchip KA, Wei Y, Puebla-Osorio N, Kaushik S, Santos MA, Wang B, Garcia-Manero G, Wang J, S-C S, and Watowich SS. Genetic rescue of lineage-balanced blood cell production reveals a crucial role for STAT3 antiinflammatory activity in hematopoiesis. Proc Natl Acad Sci USA 115(10):2311-2319, 2018. e-Pub 2018.
- Xu S, Wu X, Wu L, Castillo A, Liu J, Atkinson E, Paul A, Su D, Schlacher K, Komatsu Y, You MJ, Wang B. Abro1 maintains genome stability and limits replication stress by protecting replication fork stability. Genes Dev 31(14):1469-1482, 2017. e-Pub 2017. PMID: 28860160.
- Paul A, Wang B. RNF8- and Ube2S-Dependent Ubiquitin Lysine 11-Linkage Modification in Response to DNA Damage. Mol Cell 66(4):458-472, 2017. e-Pub 2017. PMID: 28525740.
- Wu Q, Paul A, Su D, Mehmood S, Foo TK, Ochi T, Bunting EL, Xia B, Robinson CV, Wang B, Blunder TL. Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites. *Co-corresponding authors. Mol Cell 61(3):434-48, 2016. e-Pub 2016. PMID: 26778126.
- Ling H, Hu X, Li S, Qiao F, Yao L, Cao Z, Li K, Ye F, Wang B, Shao Z. Evaluation of BRCA1 associated A complex with triple negative breast cancer susceptibility in Chinese women. *Co-corresponding authors. Oncotarget 7(9):9759-72, 2016. e-Pub 2016.
- Castillo A, Paul A, Sun B, Huang TH, Wang Y, Yazinski SA, Tyler J, Li L, You MJ, Zou L, Yao J, Wang B. The BRCA1-Interacting Protein Abraxas Is Required for Genomic Stability and Tumor Suppression. Cell Rep 8(3):807-17, 2014. e-Pub 2014. PMID: 25066119.
- Desai S, Ding M, Wang B, Lu Z, Zhao Q, Shaw K, Yung WKA, Weinstein, Tan M, Yao J. Tissue-specific isoform switch and DNA hypomethylation of the PKM2 gene in human cancer. Oncotarget 5(18):8202-10, 2013. e-Pub 2013.
- Tian F, Sharma S, Zou J, Lin SY, Wang B, Rezvani K, Wang H, Parvin JD, Ludwig T, Canman CE, Zhang D. BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade. Proc Natl Acad Sci U S A 110(33):13558-63, 2013. e-Pub 2013. PMID: 23901102.
- Hu X, Paul A, Wang B. Rap80 protein recruitment to DNA double-strand breaks requires binding to both small ubiquitin-like modifier (SUMO) and ubiquitin conjugates. J Biol Chem 287(30):25510-9, 2012. e-Pub 2012. PMID: 22689573.
- Hu X, Kim JA, Castillo A, Huang M, Liu J, Wang B. NBA1/Merit40 and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36 containing complexes. J Biol Chem 286(13):11734-45, 2011. e-Pub 2011. PMID: 21282113.
- Wang B, Hurov K, Hofmann K, Elledge SJ. NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. Genes Dev 23(6):729-39, 2009. e-Pub 2009. PMID: 19261749.
- Xiao A, Li H, Schecter D, Ahn SH, Fabrizio LA, Erdjument-Bromage H, Ishibe-Murakami S, Wang B, Tempst P, Hofmann K, Patel DJ, Elledge SJ, Allis CD. WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature 457(7225):57-62, 2009. e-Pub 2009. PMID: 19092802.
- Wang B, Elledge SJ. Ubc 13/Rnf8 ubiquitin ligase controls foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc Natl Acad Sci U S A 104(52):20759-63, 2007. e-Pub 2007. PMID: 18077395.
- Wang B, Matsuoka S, Ballif BA, Zhang D, Smogorzewska A, Gygi S, Elledge SJ. Abraxas and Rap80 form a BRCA1 protein complex required for the DNA damage response. Science 316(5828):1194-8, 2007. e-Pub 2007. PMID: 17525340.
- Adams MM, Wang B, Xia Z, Morales JC, Lu X, Donehower LA, Bochar DA, Elledge SJ, Carpenter PB. 53BP1 oligomerization is independent of its methylation by PRMT1. Cell Cycle 4(12):1854-61, 2005. e-Pub 2005. PMID: 16294047.
- Morales JC, Xia Z, Lu T, Aldrich MB, Wang B, Rosales C, Kellems RE, Hittelman WN, Elledge SJ, Carpenter PB. Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability. J Biol Chem 278(17):14971-7, 2003. e-Pub 2003. PMID: 12578828.
- Stewart G, Wang B, Bignell CR, Taylor AM, Elledge SJ. MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature 421(6926):961-6, 2003. e-Pub 2003. PMID: 12607005.
- Wang B, Matsuoka S, Carpenter PB, Elledge SJ. 53BP1 a mediator of the DNA damage checkpoint. Science 298(5597):1435-8, 2002. e-Pub 2002. PMID: 12364621.
- Wang B, Kuspa A. CulB, a putative ubiquitin ligase subunit, regulates prestalk cell differentiation and morphogenesis in Dictyostelium spp. Eukaryotic Cell 1(1):126-36, 2002. e-Pub 2002. PMID: 12455979.
- Wang B, Shaulsky G, Kuspa A. Multiple developmental roles for CRAC, a cytosolic regulator of adenylyl cyclase. Dev Biol 208(1):1-13, 1999. e-Pub 1999. PMID: 10075837.
- Wang B, Kuspa A. Dictyostelium development in the absence of cAMP. Science 277:251-4, 1997. e-Pub 1997. PMID: 9211856.
- Sanchez Y, Desany BA, Jones WJ, Liu Q, Wang B, Elledge SJ. Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science 271:357-60, 1996. e-Pub 1996. PMID: 8553072.
- Li GD, Wang B, Chen ZY, Wang Y, Gong YT. The expression of HCG epitope fused to hepatitis B virus core antigen. (Chinese) 28(2):177-86, 1996. e-Pub 1996. PMID: 12237700.
Invited Articles
- Wang B. BRCA1 Tumor Suppressor Network: Focusing on Its Tail. Cell & Bioscience 2:6, 2012. e-Pub 2012.
Abstracts
- Wang B. Replication stress response and cancer. CBIS 13th Biennial Conference, Cancer Cell Biology and Therapy, 2022. e-Pub 2022.
- Wang B. DNA damage signaling and cancer. Texas Conference on Genome Repair, "Basic Mechanisms and Clinical implications", 2022. e-Pub 2022.
- Wang B. Ubiquitin modification in DNA damage response. Fusion Conferences, 4th DNA repair/replication structures and cancer conference, 2020. e-Pub 2020.
- Wang B. Ubiquitin signaling in DNA damage response. The 10th International Symposium on DNA Damage Response & Human Disease, 2019. e-Pub 2019.
- Wu X, Liu S, Sagum C, Chen J, Singh R, Chaturvedi A, Horton JR, Cheng X, Bedford MT, Wang B. Ubiquitin signaling at DNA double strand breaks. Fusion Conferences, "Exploring DNA repair pathways as targets for cancer therapy", 2019. e-Pub 2019.
- Xu S, Wu X, Castillo A, Liu J, Atkinson E, Paul A, Su D, Schlacher K, Komatsu Y, You MJ, and Wang B. Ubiquitin linkage-specific modification of chromatin in response to DNA damage. Keystone symposium "Genomic instability and DNA repair", 2017. e-Pub 2017.
- Paul A, Wang B. Linkage-specific chromatin ubiquitination in DNA damage response. Gordon Conference "Mammalian DNA repair", 2017. e-Pub 2017.
- Castillo A, Hu X, Paul A, Su D, Wang B. DNA damage response and BRCA1 signaling. The 15th SCBA International Symposium, 2015. e-Pub 2015.
- Castillo A, Hu X, Paul A, Wu L, Sun B, Wang B. Role of a BRCA1 associated deubiquitinating complex in DNA damage response. The 14th SCBA International Symposium, 2013. e-Pub 2013.
- Castillo A, Hu X, Paul A, Liu J, Huang M, Wang B. Functional analysis of a BRCA1 associated complex in DNA damage response. Keystone Symposium: Genomic Instability and DNA Repair, 2013. e-Pub 2013.
- Wang B. Functional analysis of a BRCA1 associated complex in DNA damage response. International Workshop on Ataxia-Telangiectasia, 2012. e-Pub 2012.
- Wang B. Functional analysis of a BRCA1 associated complex in DNA damage response. SMVDU symposium "Biotechnological Advances in Cancer Biology", 2012. e-Pub 2012.
- Wang B. BRCA1 Signaling in DNA Damage Response. 4th International Conference on Biomedical and Environmental Sciences and Technology (icBEST2012), 2012. e-Pub 2012.
- Wang B. BRCA1 associated complex in DNA damage induced ubiquitin signaling. CBIS Conference "Science for Better Health", 2011. e-Pub 2011.
- Wang B. BRCA1 A complex and DNA damage induced ubiquitin signaling. AAAS SWARM Division 85th Annual Meeting, 2010. e-Pub 2010.
- Wang B, Hurov K, Hofmann K, Elledge SJ. A novel BRCA1 associated protein, NBA1, in DNA damage signaling. 21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology "Biomolecules for Quality of Life":127, 2009. e-Pub 2009.
- Wang B. BRCA1 A complex and DNA damage induced ubiquitin signaling. CBIS conference "Frontiers in Biological Sciences", 2009. e-Pub 2009.
- Wang B, Matsuoka S, Ballif B, Zhang D, Smotzgowa A, Giyi SP, Elledge SJ. Identification of a novel Brca1 associated protein complex that is involved in the DNA damage response. Keystone Symposium "Genome Instability and Repair", 2008. e-Pub 2008.
- Wang B, Matsuoka S, Morales JC, Carpenter PB, Elledge SJ. Involvement of 53BP1 in DNA damage signaling and tumor suppression. "Era of Hope" the DOD Breast Cancer Research Program Meeting, 2005. e-Pub 2005.
- Zou L, Wang B, Lin P, Matsuoka S, Wang D, Cortez D, Osborn D, Tetzloff M, Elledge SJ. Cellular responses to DNA replication stress. "Maintenance of Genomic Integrity" 55th Annual Symposium on Fundamental Cancer Research of The University of Texas M.D. Anderson Cancer Center:32, 2002. e-Pub 2002.
- Wang B, Elledge SJ. Involvement of 53BP1, a p53-binding protein, in the DNA damage response. "Era of Hope" the DOD Breast Cancer Research Program Meeting:22-10, 2002. e-Pub 2002.
Book Chapters
- Wang B. Assaying cell cycle checkpoints in mammalian cells. In: Cell Cycle Control: Mechanisms and Protocols. Second Edition. Human Press/Springer, 2014.
Patient Reviews
CV information above last modified June 05, 2026