Blaine Bartholomew, Ph.D.
Department of Epigenetics and Molecular Carcinogenesis, Division of Discovery Science
Present Title & Affiliation
Primary Appointment
Professor, Department of Epigenetics and Molecular Carcinogenesis, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Professor, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Postgraduate Training
| 1988-1991 | Postdoctoral, Gene Regulation, University of California, San Diego, San Diego, California |
Experience & Service
Administrative Appointments/Responsibilities
Deputy Department Chair, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 2023 - Present
Committee Member, NIH-NICHD-Eunice Kennedy Shriver - Site Visit, Smithville, TX, 2017 - 2017
Committee Member, Department of MGB Study Section, National Institutes of Health, Smithville, TX, 2016 - 2022
Committee Member, Department of Nucleomics Tools, ZRG1-CB-D, National Human Genome Research Institute, Smithville, TX, 2015 - 2015
Committee Member, National Human Genome Research Institute Special Emphasis Panel, Smithville, TX, 2014 - 2014
Committee Member, National Human Genome Research Institute Special Emphasis Panel (ZHG1 HGR-M), Carbondale, IL, 2011 - 2011
Ad Hoc Member, NIH-GMS MGA Study Section, Carbondale, IL, 2010 - 2010
Ad Hoc Member, NIH-GMS MGC Study Section, Carbondale, IL, 2010 - 2010
Committee Member, NIH Genes, Genomes, and Genetics Fellowship Study Section, Carbondale, IL, 2008 - 2008
Ad Hoc Member, NIH-GMS MGB Study section, Carbondale, IL, 2008 - 2009
Committee Member, NIH Institute of Aging Project Study Section, Carbondale, IL, 2007 - 2007
Committee Chair, American Cancer Society Genetic Mechanisms in Cancer, Carbondale, IL, 2006 - 2006
Committee Vice Chair, American Cancer Society (National) Scientific Review for Genetic Mechanisms in Cancer, Carbondale, IL, 2005 - 2005
Committee Member, NIH Program Project Study Section-Child Development Special Emphasis Panel, Carbondale, IL, 2003 - 2003
Committee Member, American Cancer Society (National) Scientific Review for Genetic Mechanisms in Cancer, Carbondale, IL, 2002 - 2006
Ad Hoc Member, NIH Study Section CDF-1, Carbondale, IL, 2002 - 2002
Other Appointments/Responsibilities
Member, SIU Faculty Senate, Carbondale, IL, 2011 - 2013
Committee Member, SIU Research Scholar Review Committee, Carbondale, IL, 2011 - 2012
Committee Member, SIU Departmental Search Committee, Carbondale, IL, 2008 - 2008
Committee Member, SIU Office of Research and Develop. Special Grants Review Committee, Carbondale, IL, 2007 - 2007
Committee Member, SIU School of Medicine Tenure and Promotions Committee, Carbondale, IL, 2007 - 2010
Committee Member, SIU Departmental Search Committee, Carbondale, IL, 2006 - 2006
Organizer, SIU MBMB Seminar, Carbondale, IL, 2004 - 2005
Committee Member, SIU Departmental Search Committee, Carbondale, IL, 2003 - 2003
Chair, SIU MBMB Program Operating Paper Committee, Carbondale, IL, 2002 - 2002
Committee Member, SIU Development of integrated curriculum for MBMB graduate program, Carbondale, IL, 2002 - 2002
Committee Member, SIU Reorganization of Biochemistry Curriculum in Sequence 1, Carbondale, IL, 1999 - 1999
Organizer, SIU MBMB Seminar, Carbondale, IL, 1999 - 2000
Committee Member, SIU Graduate Student Admission Committee, Carbondale, IL, 1997 - 2013
Institutional Committee Activities
Committee Member, EMC Chair Departmental Advisory Committee, 2024 - 2024
Committee Member, GSBS Curriculum Committee, 2021 - 2023
Committee Member, GEC, 2016 - 2016
Member, GSBS, 2014 - 2015
Committee Member, Graduate Program, 2014 - 2014
Co-Chair, SIU Molecular and Cellular Biology Symposium, 2004 - 2006
Committee Member, SIU Central Research Committee, 2001 - 2004
Subcommittee Member, SIU Research Pathways Subcommittee for Curriculum, 2000 - 2000
Chair, SIU Molecular and Cellular Biology Symposium, 1994 - 2003
Honors & Awards
| American Cancer Society Fellow, University of California, San Diego, Center for Molecular Genetics | |
| American Cancer Society Researcher Award | |
| Excellence through Commitment Award, Outstanding Scholar, Southern Illinois University |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Saha, D, Animireddy, S, Lee, J, Thommen, A, Murvin, MM, Lu, Y, Calabrese, JM, Bartholomew, B. Enhancer switching in cell lineage priming is linked to eRNA, Brg1’s AT-hook, and SWI/SNF recruitment. Molecular cell 84(10):1855-1869.e5, 2024. PMID: 38593804.
- Saha D, Hailu S, Hada A, Lee J, Luo J, Ranish JA, Lin YC, Feola K, Persinger J, Jain A, Liu B, Lu Y, Sen P, Bartholomew B. The AT-hook is an evolutionarily conserved auto-regulatory domain of SWI/SNF required for cell lineage priming. Nat Commun 14(1):4682, 2023. e-Pub 2023. PMID: 37542049.
- Bhardwaj SK, Hailu SG, Olufemi L, Brahma S, Kundu S, Hota SK, Persinger J, Bartholomew B. Dinucleosome specificity and allosteric switch of the ISW1a ATP-dependent chromatin remodeler in transcription regulation. Nat Commun 11(1):5913, 2020. e-Pub 2020. PMID: 33219211.
- He W, Zhang L, Villarreal OD, Fu R, Bedford E, Dou J, Patel AY, Bedford MT, Shi X, Chen T, Bartholomew B, Xu H. Author Correction: De novo identification of essential protein domains from CRISPR-Cas9 tiling-sgRNA knockout screens. Nat Commun 11(1):1134, 2020. e-Pub 2020. PMID: 32098955.
- He W, Zhang L, Villarreal OD, Fu R, Bedford E, Dou J, Patel AY, Bedford MT, Shi X, Chen T, Bartholomew B, Xu H. De novo identification of essential protein domains from CRISPR-Cas9 tiling-sgRNA knockout screens. Nat Commun 10(1):4541, 2019. e-Pub 2019. PMID: 31586052.
- Hada A, Hota SK, Luo J, Lin YC, Kale S, Shaytan AK, Bhardwaj SK, Persinger J, Ranish J, Panchenko AR, Bartholomew B. Histone Octamer Structure Is Altered Early in ISW2 AT-Dependent Nucleosome Remodeling. Cell Rep 28(1):282-294.e6, 2019. PMID: 31269447.
- Brahma S, Ngubo M, Paul S, Udugama M, Bartholomew B. The Arp8 and Arp4 module acts as a DNA sensor controlling INO80 chromatin remodeling. Nat Commun 9(1):3309, 2018. e-Pub 2018. PMID: 30120252.
- Brahma S, Udugama MI, Kim J, Hada A, Bhardwaj SK, Hailu SG, Lee TH, Bartholomew B. INO80 exchanges H2A.Z for H2A by translocating on DNA proximal to histone dimers. Nat Commun 8:15616, 2017. e-Pub 2017. PMID: 28604691.
- Sen P, Luo J, Hada A, Hailu SG, Dechassa ML, Persinger J, Brahma S, Paul S, Ranish J, Bartholomew B. Loss of Snf5 Induces Formation of an Aberrant SWI/SNF Complex. Cell Rep 18(9):2135-2147, 2017. PMID: 28249160.
- Prasad R, D'Arcy S, Hada A, Luger K, Bartholomew B. Coordinated action of Nap1 and RSC in disassembly of tandem nucleosomes. Mol Cell Biol 36(17):2262-71, 2016. e-Pub 2016. PMID: 27273866.
- Harada BT, Hwang WL, Deindl S, Chatterjee N, Bartholomew B, Zhuang X. Stepwise nucleosome translocation by RSC remodeling complexes. Elife 5, 2016. e-Pub 2016. PMID: 26895087.
- Chatterjee N, North JA, Dechassa ML, Manohar M, Prasad R, Luger K, Ottesen JJ, Poirier MG, Bartholomew B. Histone Acetylation near the Nucleosome Dyad Axis Enhances Nucleosome Disassembly by RSC and SWI/SNF. Mol Cell Biol 35(23):4083-92, 2015. e-Pub 2015. PMID: 26416878.
- Lafon A, Taranum S, Pietrocola F, Dingli F, Loew D, Brahma S, Bartholomew B, Papamichos-Chronakis M. INO80 Chromatin Remodeler Facilitates Release of RNA Polymerase II from Chromatin for Ubiquitin-Mediated Proteasomal Degradation. Mol Cell 60(5):784-796, 2015. e-Pub 2015. PMID: 26656161.
- Kim SA, Chatterjee N, Jennings MJ, Bartholomew B, Tan S. Extranucleosomal DNA enhances the activity of the LSD1/CoREST histone demethylase complex. Nucleic Acids Res 43(10):4868-80, 2015. e-Pub 2015. PMID: 25916846.
- Kapoor P, Bao Y, Xiao J, Luo J, Shen J, Persinger J, Peng G, Ranish J, Bartholomew B, Shen X. Regulation of Mec1 kinase activity by the SWI/SNF chromatin remodeling complex. Genes Dev 29(6):591-602, 2015. PMID: 25792597.
- Li M, Hada A, Sen P, Olufemi L, Hall MA, Smith BY, Forth S, McKnight JN, Patel A, Bowman GD, Bartholomew B, Wang MD. Dynamic regulation of transcription factors by nucleosome remodeling. Elife 4, 2015. e-Pub 2015. PMID: 26047462.
Invited Articles
- Paul S, Bartholomew B. Regulation of ATP-dependent chromatin remodelers: Accelerators/Brakes, Anchors and Sensors. Biochem Soc Trans 46(6):1423-1430, 2018. e-Pub 2018. PMID: 30467122.
- Meng H, Bartholomew B. Emerging Roles of Transcriptional Enhancers In Chromatin Looping And Promoter-Proximal Pausing Of RNA Polymerase II. J Biol Chem 293(36):13786-13794, 2018. e-Pub 2017. PMID: 29187597.
- Bartholomew B. Proteasomes beyond proteolysis: Roles in heterochromatin maintenance. J Biol Chem 292(41):17156-17157, 2017. PMID: 29030538.
Other Articles
- Saha, D, Animireddy, S, Bartholomew, B The SWI/SNF ATP-dependent chromatin remodeling complex in cell lineage priming and early development. Biochemical Society Transactions 52(2):603-616, 2024. PMID: 38572912.
- Bartholomew B, Shukla S, Ngubo M, Paul S, Persinger J, Brahma S New insights into the mechanism and DNA-sequence specificity of INO80 chromatin remodeling. Res Sq Preprint, 2023. PMID: 37961512.
- Saha D, Animireddy S, Lee J, Thommen A, McKenzie M, Lu Y, Calabrese M, Bartholomew B Super-Enhancer Swithing in Early Mammalian Development Involves eRNA Mediated SWI/SNF Recruitment. SneakPeak Prepring, 2023. PMID: None.
Grant & Contract Support
| Title: | Regulation of Transcription and Nuclear Architecture by SWI/SNF |
| Funding Source: | Internal/Bridge Funding |
| Role: | PI |
| Title: | Regulation of sub-TAD organization and enhancer-promoter interactions by SWI/SNF and its AT-hook |
| Funding Source: | Internal/Bridge Funding (Life Changing Event) |
| Role: | PI |
Patient Reviews
CV information above last modified January 21, 2025