Bofei Wang, Ph.D.
Department of Leukemia, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Instructor, Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas
Research Interests
I am an Instructor in the department of Leukemia at MD Anderson Cancer Center. I have a broad background in bioinformatics, computational biology and machine learning, with specific training in high dimensional data analysis and machine learning on multi-omics data. My research interest focuses on application of integrative, multi-omics computational approaches/tools to understand the intrinsic and extrinsic factors associated with resistance to chemo- and immuno-therapy in acute myeloid leukemia (AML) patients. I leveraged computational approaches and multi-omics data including RNA, T- and B-cell receptor, and chromatin accessibility on bulk or single cell level to identify the interactions of leukemic cells with their microenvironment, emphasizing the role of IFN-γ and inflammation in therapeutic resistance pathways . I also worked on characterizing T cell dysfunctional states, define AML hierarchies and investigating inflammatory dynamics by high throughput proteomic profiling .
Education & Training
Degree-Granting Education
| 2021 | The University of Texas at El Paso, El Paso, Texas, US, Computational Science, Ph.D |
| 2019 | The University of Texas at El Paso, El Paso, Texas, US, Computational Science, Masters |
| 2017 | The University of Texas at El Paso, El Paso, Texas, US, Bioinformatics, Masters |
| 2015 | Tianjin University of Science & Technology, Tianjin, CN, Biotechnology, Bachelor |
Postgraduate Training
| 2022-2025 | Postdoctoral Fellow, The University of Texas MD Anderson Cancer Center, Houston, Texas |
Honors & Awards
| 2024 | Research Excellence Award for Leukemia Research, MD Anderson Cancer Center |
| 2024 | Trainee Research Day Poster Award, MD Anderson Cancer Center |
| 2015 | Excellent Graduate, Tianjin University of Science &Technology |
| 2012 | National Scholarship for Academic Performance, Ministry of Education, China |
Selected Publications
Peer-Reviewed Articles
- Radpour R, Simillion C, Wang B, Abbas HA, Riether C, Ochsenbein AF. IL-9 secreted by leukemia stem cells induces Th1-skewed CD4+ T cells, which promote their expansion. Blood 144(8):888-903, 2024. e-Pub 2024. PMID: 38941612.
- Narayanan N, Marvin-Peek J, Abouelnaaj MK, Majid D, Wang B, Brown BD, Qiu Y, Kornblau SM, Abbas HA. Reverse Phase Proteomic Array Profiling of Asparagine Synthetase Expression in Newly Diagnosed Acute Myeloid Leukemia. J Proteome Res 23(7):2495-2504, 2024. e-Pub 2024. PMID: 38829961.
- Wang Y, Deng C, Zhao L, Dimkpa CO, Elmer WH, Wang B, Sharma S, Wang Z, Dhankher OP, Xing B, White JC. Time-Dependent and Coating Modulation of Tomato Response upon Sulfur Nanoparticle Internalization and Assimilation: An Orthogonal Mechanistic Investigation. ACS Nano 18(18):11813-11827, 2024. e-Pub 2024. PMID: 38657165.
- Kang HA, Wang B, Barner JC, Ataga KI, Mignacca RC, Chang A, Zhang Y. Opioid Prescribing and Outcomes in Patients With Sickle Cell Disease Post-2016 CDC Guideline. JAMA Intern Med 184(5):510-518, 2024. e-Pub 2024. PMID: 38466269.
- Root JL, Desai PN, Ly C, Wang B, Jelloul FZ, Zhou J, Mackay S, Alfayez M, Matthews J, Pierce S, Reville PK, Daver N, Abbas HA. Single-Cell CD4 and CD8 T-Cell Secretome Profiling Reveals Temporal and Niche Differences in Acute Myeloid Leukemia Following Immune Checkpoint Blockade Therapy. Cancer Res Commun 4(3):671-681, 2024. e-Pub 2024. PMID: 38391202.
- Wang B, Reville PK, Yassouf MY, Jelloul FZ, Ly C, Desai PN, Wang Z, Borges P, Veletic I, Dasdemir E, Burks JK, Tang G, Guo S, Garza AI, Nasnas C, Vaughn NR, Baran N, Deng Q, Matthews J, Gunaratne PH, Antunes DA, Ekmekcioglu S, Sasaki K, Garcia MB, Cuglievan B, Hao D, Daver N, Green MR, Konopleva M, Futreal A, Post SM, Abbas HA. Comprehensive characterization of IFNgamma signaling in acute myeloid leukemia reveals prognostic and therapeutic strategies. Nat Commun 15(1):1821, 2024. e-Pub 2024. PMID: 38418901.
- Guo S, Mohan GS, Wang B, Li T, Daver N, Zhao Y, Reville PK, Hao D, Abbas HA. Paired single-B-cell transcriptomics and receptor sequencing reveal activation states and clonal signatures that characterize B cells in acute myeloid leukemia. J Immunother Cancer 12(2), 2024. e-Pub 2024. PMID: 38418394.
- Wang K, Qiu C, Xing M, Li M, Wang B, Ye H, Shi J, Dai L, Wang X, Wang P. Association of elevated autoantibody to high expression of GNAS in hepatocellular carcinoma. Heliyon 9(12):e22627, 2023. e-Pub 2023. PMID: 38107305.
- Qiu C, Wang X, Batson SA, Wang B, Casiano CA, Francia G, Zhang JY. A Luminex Approach to Develop an Anti-Tumor-Associated Antigen Autoantibody Panel for the Detection of Prostate Cancer in Racially/Ethnically Diverse Populations. Cancers (Basel) 15(16), 2023. e-Pub 2023. PMID: 37627091.
- Fan H, Wang F, Zeng A, Murison A, Tomczak K, Hao D, Jelloul FZ, Wang B, Barrodia P, Liang S, Chen K, Wang L, Zhao Z, Rai K, Jain AK, Dick J, Daver N, Futreal A, Abbas HA. Single-cell chromatin accessibility profiling of acute myeloid leukemia reveals heterogeneous lineage composition upon therapy-resistance. Commun Biol 6(1):765, 2023. e-Pub 2023. PMID: 37479893.
- Desai PN, Wang B, Fonseca A, Borges P, Jelloul FZ, Reville PK, Lee E, Ly C, Basi A, Root J, Baran N, Post SM, Deng Q, Sun H, Harmanci AO, Burks JK, Gomez JA, DiNardo CD, Daver NG, Alatrash G, Konopleva M, Green MR, Antunes DA, Futreal A, Hao D, Abbas HA. Single-Cell Profiling of CD8+ T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion. Cancer Immunol Res:OF1-OF18, 2023. e-Pub 2023. PMID: 37285177.
- Qiu C, Ma Y, Wang B, Zhang X, Wang X, Zhang JY. Autoantibodies to PAX5, PTCH1, and GNA11 as Serological Biomarkers in the Detection of Hepatocellular Carcinoma in Hispanic Americans. Int J Mol Sci 24(4), 2023. e-Pub 2023. PMID: 36835134.
- Rutella S, Vadakekolathu J, Mazziotta F, Reeder S, Yau TO, Mukhopadhyay R, Dickins B, Altmann H, Kramer M, Knaus HA, Blazar BR, Radojcic V, Zeidner JF, Arruda A, Wang B, Abbas HA, Minden MD, Tasian SK, Bornhauser M, Gojo I, Luznik L. Immune dysfunction signatures predict outcomes and define checkpoint blockade-unresponsive microenvironments in acute myeloid leukemia. J Clin Invest 132(21), 2022. e-Pub 2022. PMID: 36099049.
- Ma Y, Qiu C, Wang B, Zhang X, Wang X, Aguilera RJ, Zhang JY. Autoantibody against Tumor-Associated Antigens as Diagnostic Biomarkers in Hispanic Patients with Hepatocellular Carcinoma. Cells 11(20), 2022. e-Pub 2022. PMID: 36291095.
- Wang X, Wang K, Qiu C, Wang B, Zhang X, Ma Y, Dai L, Zhang JY. Autoantibody to GNAS in Early Detection of Hepatocellular Carcinoma: A Large-Scale Sample Study Combined with Verification in Serial Sera from HCC Patients. Biomedicines 10(1), 2022. e-Pub 2022. PMID: 35052777.
Letters to the Editor
- Wang, Y, Deng, C, Zhao, L, Dimkpa, CO, Elmer, WH, Wang, B, Sharma, S, Wang, Z, Dhankher, OP, Xing, B, White, JC. Reply to the Letter to the Editor. ACS Nano 18: 33771-33774, 2024.
Selected Presentations & Talks
Regional Presentations
- Identification of prostate cancer-associated genomic alternations by analyzing variant frequencies, functional effects, and protein interactions. Conference. AMS Fall Central Sectional Meeting 2022. El Paso, Texas, US.
Patient Reviews
CV information above last modified March 25, 2025