
Boyi Gan, Ph.D.
Department of Experimental Radiation Oncology, Division of Radiation Oncology
Present Title & Affiliation
Primary Appointment
Endowed Distinguished Professor N.G. and Hellen T. Hawkins Distinguished Professor for Cancer Research, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Director, Acquired Resistance to Therapy and Iron (ARTI) Center, MD Anderson Cancer Center, Houston, TX
Professor, Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Director, Radiation and Cancer Metabolism Research Program, MD Anderson Cancer Center, Houston, TX
Professor, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
Targeting Metabolic Cell Death in Cancer: Ferroptosis and Disulfidptosis
Our research lies at the intersection of cancer metabolism and regulated cell death, with a focus on two key questions: (1) how cancer cells either resist or undergo cell death in response to metabolic stress or cancer therapy (particularly radiotherapy), and (2) how to develop therapies that leverage these cell death pathways to overcome therapy resistance.
Our work centers on three interrelated areas. First, we study ferroptosis, a lipid peroxidation-driven form of cell death, as a mechanism of tumor suppression and therapeutic response. We have uncovered the significance of ferroptosis as a critical mechanism for tumor suppression, particularly in the context of radiotherapy and other cancer treatments. These findings have provided valuable insights into the understanding and targeting of ferroptosis in cancer therapy. (Nature Cell Biology, 2018; Nature Cell Biology, 2020a; Nature Communications, 2021, 2024; Nature, 2021; PNAS, 2022; Cancer Discovery, 2024; Cancer Cell, 2024). Second, we discovered disulfidptosis as a form of cell death induced by disulfide stress, and we have been actively studying disulfidptosis and its relevance to cancer therapy. (Nature Cell Biology, 2020b; Nature Cell Biology, 2023; Nature Communications, 2023). Finally, we have investigated the roles of metabolic cell death pathways—including ferroptosis and cuproptosis—in the context of radiotherapy (RT). We showed that ferroptosis mediates RT-induced tumor suppression and proposed combining RT with ferroptosis inducers (Cell Research, 2020; Nature Communications, 2022; Nature Reviews Cancer, 2022; Molecular Cell, 2024). Our recent study also revealed a role of cuproptosis (a form of copper-induced cell death) in overcoming tumor radioresistance (Cancer Cell, 2025), which is relevant to the proposed research in this application.
For more information, please visit our lab webpage: https://www.mdanderson.org/research/departments-labs-institutes/labs/gan-laboratory.html
Education & Training
Degree-Granting Education
2006 | Cornell University, Ithaca, New York, US, Comparative Biomedical Sciences, Ph.D |
2000 | Fudan University, Shanghai, CN, Genetics, M.S |
1997 | Fudan University, Shanghai, CN, Microbiology, BS |
Postgraduate Training
2010-2011 | Instructor, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts |
2006-2010 | Postdoctoral Fellow, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts |
Experience & Service
Academic Appointments
Associate Professor, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2017 - 2021
Associate Professor, Department of Experimental Radiation Onc, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2017 - 2021
Assistant Professor, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2012 - 2017
Assistant Professor, Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2011 - 2017
Administrative Appointments/Responsibilities
Director, Acquired Resistance to Therapy and Iron (ARTI) Center, MD Anderson Cancer Center, Houston, TX, 2022 - Present
Director, Radiation and Cancer Metabolism Research Program, MD Anderson Cancer Center, Houston, TX, 2021 - Present
Honors & Awards
2025 | Distinguished Research Faculty Mentor Award (Research), MD Anderson Cancer Center |
2023 | Lombardi 7 Blocks of Granite Champions award, the Rotary Club of Houston Lombardi Committee |
2023 - Present | American Association for the Advancement of Science (AAAS) Fellow, American Association for the Advancement of Science (AAAS) |
2023 | Honor to be highlighted in the Wall of Science at MD Anderson, MD Anderson Cancer Center |
2023 - Present | N.G. and Hellen T. Hawkins Distinguished Professor for Cancer Research, MD Anderson Cancer Center |
2022 | Faculty Honoree Award in Research Excellence, MD Anderson Cancer Center |
2022 | Honor to be highlighted in the Wall of Science, MD Anderson Cancer Center |
2021 | The Dallas/Fort Worth Living Legend Faculty Achievement Award in Basic Research, MD Anderson Cancer Center |
2021 | Faculty Honoree Award in Research Excellence, MD Anderson Cancer Center |
2021 | Honor to be highlighted in the Wall of Science, MD Anderson Cancer Center |
2020 | Faculty Honoree Award in Research Excellence, MD Anderson Cancer Center |
2018 | MD Anderson Faculty Scholar Award, MD Anderson Cancer Center |
2017 - 2019 | Andrew Sabin Family Award, MD Anderson Cancer Center |
2016 - 2019 | Anna Fuller Foundation Award, Anna Fuller Foundation |
2013 - 2016 | Gabrielle's Angel Foundation Award, Gabrielle's Angel Foundation for Cancer Research |
2013 - 2017 | Ellison Medical Foundation New Scholar Award, Ellison Medical Foundation |
2012 - 2014 | CSCDB Faculty Scholar Award, Center for Stem Cell and Developmental Biology, UT MD Anderson Cancer Center |
2012 - 2013 | The LAM Foundation Pilot Award, The LAM Foundation |
2012 - 2014 | CONquer canCER Now Award, Concern Foundation |
2012 - 2014 | Kimmel Scholar, Sidney Kimmel Foundation |
2011 | Harvard Chinese Life Science Annual Distinguished Research Award, Harvard Chinese Life Science Association |
2011 - 2016 | MDACC Trust Scholar, MD Anderson Cancer Center |
2011 - 2014 | STARS Award, University of Texas |
2011 - 2012 | DOD PCRP Exploration - Hypothesis Development Award, Department of Defense |
2010 - 2014 | DOD TSCRP Career Transition Award, Department of Defense |
2009 - 2011 | DF/HCC Kidney Cancer SPORE Career Development Award, DF/HCC Kidney Cancer SPORE |
2007 - 2010 | Leukemia & Lymphoma Society Fellowship, Leukemia & Lymphoma Society |
Selected Publications
Peer-Reviewed Articles
- Zhao Z, Hu B, Deng Y, Soeung M, Yao J, Bei L, Zhang Y, Gong P, Huang LA, Jiang Z, Gao J, Peng S, Nguyen TK, Karki M, Lim B, Yee C, Burks JK, Zhang Q, Ma L, Gao J, Tannir NM, Han L, Yu D, Wang L, Curran MA, Gubbiotti MA, Genovese G, Gan B, Li W, Msaouel P, Yang L, Lin C. Sickle cell disease induces chromatin introversion and ferroptosis in CD8(+) T cells to suppress anti-tumor immunity. Immunity 58(6):1484-1501.e11, 2025. e-Pub 2025. PMID: 40359940.
- Lei G, Sun M, Cheng J, Ye R, Lu Z, Horbath A, Huo D, Wu S, Alapati A, Aggarwal S, Xu Z, Mao C, Yan Y, Yao J, Li Q, Chen X, Lee H, Zhuang L, Jiang D, Pataer A, Roth JA, Navin N, Koong AC, You MJ, Lin SH, Gan B. Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance. Cancer Cell 43(6):1076-1092.e5, 2025. e-Pub 2025. PMID: 40215978.
- Li Q, Gan B. Disulfidptosis meets antitumour immunity. Nat Cell Biol 27(6):886-887, 2025. e-Pub 2025. PMID: 40473855.
- Teng H, Hang Q, Zheng C, Yan Y, Liu S, Zhao Y, Deng Y, Nie L, Wu W, Sheldon M, Yu Z, Shi W, Gao J, Meng C, Martinez C, Zhang J, Yao F, Sun Y, Zhao D, Gan B, Meng T, Ma L. In vivo CRISPR activation screen identifies acyl-CoA-binding protein as a driver of bone metastasis. Sci Transl Med 17(799):eado7225, 2025. e-Pub 2025. PMID: 40397713.
- Meng C, Lin K, Shi W, Teng H, Wan X, DeBruine A, Wang Y, Liang X, Leo J, Chen F, Gu Q, Zhang J, Van V, Maldonado KL, Gan B, Ma L, Lu Y, Zhao D. Histone methyltransferase ASH1L primes metastases and metabolic reprogramming of macrophages in the bone niche. Nat Commun 16(1):4681, 2025. e-Pub 2025. PMID: 40394007.
- Chen, F, Li, H, Wang, Y, Tang, X, Lin, H, Li, Q, Meng, C, Shi, W, Leo, J, Liang, X, Zhang, J, Van, V, Mahmud, I, Wei, B, Lorenzi, PL, Raso, G, Aparicio, A, Lu, Y, Frigo, DE, Gan, B, Zhao, D. CHD1 loss reprograms SREBP2-driven cholesterol synthesis to fuel androgen-responsive growth and castration resistance in SPOP-mutated prostate tumors. Nature Cancer 6(5):854-873, 2025. e-Pub 2025. PMID: 40360905.
- Li Q, Zhuang L, Gan B. Disulfidptosis. Curr Biol 35(7):R241-R243, 2025. e-Pub 2025. PMID: 40199244.
- Fan Y, Wang Y, Dan W, Zhang Y, Nie L, Ma Z, Zhuang Y, Liu B, Li M, Liu T, Wang Z, Ye L, Wei Y, Lei Y, Guo C, An J, Wang C, Zhang Y, Zeng J, Wei W, Gan B, Li L. PRMT5-mediated arginine methylation stabilizes GPX4 to suppress ferroptosis in cancer. Nat Cell Biol 27(4):641-653, 2025. e-Pub 2025. PMID: 40033101.
- Freitas-Cortez MA, Masrorpour F, Jiang H, Mahmud I, Lu Y, Huang A, Duong LK, Wang Q, Voss TA, Kettlun Leyton CS, Wei B, Chan WK, Lin K, Zhang J, Tsouko E, Ganjoo S, Barsoumian HB, Riad TS, Hu Y, Leuschner C, Puebla-Osorio N, Wang J, Hu J, Davies MA, Puduvalli VK, Billon C, Burris TP, Lorenzi PL, Gan B, Welsh JW. Cancer cells avoid ferroptosis induced by immune cells via fatty acid binding proteins. Mol Cancer 24(1):40, 2025. e-Pub 2025. PMID: 39901247.
- Yan Y, Zhuang L, Gan B. GPR56: GPCR as a guardian against ferroptosis. Cell Metab 36(11):2355-2356, 2024. e-Pub 2024. PMID: 39504935.
- Conradt B, Miao EA, Yuan J, Kanneganti TD, Stockwell BR, Tsvetkov P, Overholtzer M, Gan B. The story behind the emergence of different forms of cell death. Dev Cell 59(19):2519-2522, 2024. e-Pub 2024. PMID: 39378837.
- Yan Y, Gan B. Dodging death. Nat Chem Biol 20(10):1252-1253, 2024. e-Pub 2024. PMID: 38720106.
- Liu X, Chen Z, Yan Y, Zandkarimi F, Nie L, Li Q, Horbath A, Olszewski K, Kondiparthi L, Mao C, Lee H, Zhuang L, Poyurovsky M, Stockwell BR, Chen J, Gan B. Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis. Protein Cell 15(9):686-703, 2024. e-Pub 2024. PMID: 38430542.
- Mao C, Wang M, Zhuang L, Gan B. Metabolic cell death in cancer: Ferroptosis, cuproptosis, disulfidptosis, and beyond. Protein Cell 15(9):642-660, 2024. e-Pub 2024. PMID: 38428031.
- Dai E, Chen X, Linkermann A, Jiang X, Kang R, Kagan VE, Bayir H, Yang WS, Garcia-Saez AJ, Ioannou MS, Janowitz T, Ran Q, Gu W, Gan B, Krysko DV, Zhu X, Wang J, Krautwald S, Toyokuni S, Xie Y, Greten FR, Yi Q, Schick J, Liu J, Gabrilovich DI, Liu J, Zeh HJ, Zhang DD, Yang M, Iovanna J, Kopf M, Adolph TE, Chi JT, Li C, Ichijo H, Karin M, Sankaran VG, Zou W, Galluzzi L, Bush AI, Li B, Melino G, Baehrecke EH, Lotze MT, Klionsky DJ, Stockwell BR, Kroemer G, Tang D. A guideline on the molecular ecosystem regulating ferroptosis. Nat Cell Biol 26(9):1447-1457, 2024. e-Pub 2024. PMID: 38424270.
- Lee H, Zhuang L, Gan B. Rewiring cancer cell death: LPCAT1 shapes lipid composition and ferroptosis resistance. Cell Death Differ 31(9):1101-1103, 2024. e-Pub 2024. PMID: 39138374.
- Lei G, Mao C, Horbath AD, Yan Y, Cai S, Yao J, Jiang Y, Sun M, Liu X, Cheng J, Xu Z, Lee H, Li Q, Lu Z, Zhuang L, Chen MK, Alapati A, Yap TA, Hung MC, You MJ, Piwnica-Worms H, Gan B. BRCA1-mediated dual regulation of ferroptosis exposes a vulnerability to GPX4 and PARP co-inhibition in BRCA1-deficient cancers. Cancer Discov 14(8):1476-1495, 2024. e-Pub 2024. PMID: 38552003.
- Mao C, Lei G, Horbath A, Wang M, Lu Z, Yan Y, Liu X, Kondiparthi L, Chen X, Cheng J, Li Q, Xu Z, Zhuang L, Fang B, Marszalek JR, Poyurovsky MV, Olszewski K, Gan B. Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers. Mol Cell 84(10):1964-1979.e6, 2024. e-Pub 2024. PMID: 38759628.
- Jiang D, Guo Y, Wang T, Wang L, Yan Y, Xia L, Bam R, Yang Z, Lee H, Iwawaki T, Gan B, Koong AC. IRE1alpha determines ferroptosis sensitivity through regulation of glutathione synthesis. Nat Commun 15(1):4114, 2024. e-Pub 2024. PMID: 38750057.
- Lee H, Zhuang L, Gan B. VHL governs m6A modification and PIK3R3 mRNA stability in clear cell renal cell carcinomas. J Clin Invest 134(8), 2024. e-Pub 2024. PMID: 38618953.
- Lei G, Zhuang L, Gan B. The roles of ferroptosis in cancer: Tumor suppression, tumor microenvironment, and therapeutic interventions. Cancer Cell 42(4):513-534, 2024. e-Pub 2024. PMID: 38593779.
- Nie L, Wang C, Huang M, Liu X, Feng X, Tang M, Li S, Hang Q, Teng H, Shen X, Ma L, Gan B, Chen J. DePARylation is critical for S phase progression and cell survival. Elife 12, 2024. e-Pub 2024. PMID: 38578205.
- Lei G, Gan B. Exploring Ferroptosis-Inducing Therapies for Cancer Treatment: Challenges and Opportunities. Cancer Res 84(7):961-964, 2024. e-Pub 2024. PMID: 38558130.
- Liu X, Zhuang L, Gan B. Disulfidptosis: disulfide stress-induced cell death. Trends Cell Biol 34(4):327-337, 2024. e-Pub 2024. PMID: 37574347.
- Bi G, Liang J, Bian Y, Shan G, Huang Y, Lu T, Zhang H, Jin X, Chen Z, Zhao M, Fan H, Wang Q, Gan B, Zhan C. Polyamine-mediated ferroptosis amplification acts as a targetable vulnerability in cancer. Nat Commun 15(1):2461, 2024. e-Pub 2024. PMID: 38504107.
- Chen X, Gan B. SLC25A39 links mitochondrial GSH sensing with iron metabolism. Mol Cell 84(4):616-618, 2024. e-Pub 2024. PMID: 38364779.
- Nie L, Wang C, Huang M, Liu X, Feng X, Tang M, Li S, Hang Q, Teng H, Shen X, Ma L, Gan B, Chen J. DePARylation is critical for S phase progression and cell survival. bioRxiv, 2024. e-Pub 2024. PMID: 37577639.
- Lee H, Horbath A, Kondiparthi L, Meena JK, Lei G, Dasgupta S, Liu X, Zhuang L, Koppula P, Li M, Mahmud I, Wei B, Lorenzi PL, Keyomarsi K, Poyurovsky MV, Olszewski K, Gan B. Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance. Nat Commun 15(1):79, 2024. e-Pub 2024. PMID: 38167301.
- Yan Y, Gan B. Hyperoxidized PRDX3 as a specific ferroptosis marker. Life Metab 2(6), 2023. e-Pub 2023. PMID: 38179338.
- Zhang S, Gou S, Zhang Q, Yong X, Gan B, Jia D. FSP1 oxidizes NADPH to suppress ferroptosis. Cell Res 33(12):967-970, 2023. e-Pub 2023. PMID: 37739993.
- Liu X, Zhuang L, Gan B. Unleashing ferroptosis for cancer therapy with warfarin. Trends Endocrinol Metab 34(11):683-684, 2023. e-Pub 2023. PMID: 37648560.
- Huang S, Zhang Q, Zhao M, Wang X, Zhang Y, Gan B, Zhang P. The deubiquitinase ZRANB1 is an E3 ubiquitin ligase for SLC7A11 and regulates ferroptotic resistance. J Cell Biol 222(11), 2023. e-Pub 2023. PMID: 37831441.
- Li Q, Gan B. Uncovering the IL-1β-PCAF-NNT axis: A new player in ferroptosis and tumor immune evasion. Cancer Commun (Lond) 43(9):1048-1050, 2023. e-Pub 2023. PMID: 37488943.
- Wang Z, Ouyang L, Liu N, Li T, Yan B, Mao C, Xiao D, Gan B, Liu S, Tao Y. The DUBA-SLC7A11-c-Myc axis is critical for stemness and ferroptosis. Oncogene 42(36):2688-2700, 2023. e-Pub 2023. PMID: 37537342.
- Gan B. The pyrimidinosome: Orchestrating pyrimidine biosynthesis and ferroptosis defense. Mol Cell 83(16):2837-2839, 2023. e-Pub 2023. PMID: 37595553.
- Zhang Y, Zhao Z, Huang LA, Liu Y, Yao J, Sun C, Li Y, Zhang Z, Ye Y, Yuan F, Nguyen TK, Garlapati NR, Wu A, Egranov SD, Caudle AS, Sahin AA, Lim B, Beretta L, Calin GA, Yu D, Hung MC, Curran MA, Rezvani K, Gan B, Tan Z, Han L, Lin C, Yang L. Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation. Cell Metab 35(8):1457-1473.e13, 2023. e-Pub 2023. PMID: 37329887.
- Mao C, Liu X, Yan Y, Olszewski K, Gan B. Reply to: DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition. Nature 619(7968):E19-E23, 2023. e-Pub 2023. PMID: 37407682.
- Bi G, Liang J, Shan G, Bian Y, Chen Z, Huang Y, Lu T, Li M, Besskaya V, Zhao M, Fan H, Wang Q, Gan B, Zhan C. Retinol Saturase Mediates Retinoid Metabolism to Impair a Ferroptosis Defense System in Cancer Cells. Cancer Res 83(14):2387-2404, 2023. e-Pub 2023. PMID: 37184371.
- Lee H, Zhuang L, Gan B. Ferroptosis vulnerability in FLT3-mutant leukemia. Trends Cancer 9(7):524-525, 2023. e-Pub 2023. PMID: 37173186.
- Yan Y, Teng H, Hang Q, Kondiparthi L, Lei G, Horbath A, Liu X, Mao C, Wu S, Zhuang L, James You M, Poyurovsky MV, Ma L, Olszewski K, Gan B. SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells. Nat Commun 14(1):3673, 2023. e-Pub 2023. PMID: 37339981.
- Gan B. Ferroptosis hijacking by Mycobacterium tuberculosis. Nat Commun 14(1):1431, 2023. e-Pub 2023. PMID: 36932073.
- Liu X, Nie L, Zhang Y, Yan Y, Wang C, Colic M, Olszewski K, Horbath A, Chen X, Lei G, Mao C, Wu S, Zhuang L, Poyurovsky MV, James You M, Hart T, Billadeau DD, Chen J, Gan B. Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis. Nat Cell Biol 25(3):404-414, 2023. e-Pub 2023. PMID: 36747082.
- Gan B. How erastin assassinates cells by ferroptosis revealed. Protein Cell 14(2):84-86, 2023. e-Pub 2023. PMID: 36929006.
- Gan, B. A Time and Place for Inhibiting Autophagy. Cancer Research 82(23):4322-4324, 2022. e-Pub 2022. PMID: 36458406.
- Nie L, Wang C, Liu X, Teng H, Li S, Huang M, Feng X, Pei G, Hang Q, Zhao Z, Gan B, Ma L, Chen J. USP7 substrates identified by proteomics analysis reveal the specificity of USP7. Genes Dev 36(17-18):1016-1030, 2022. e-Pub 2022. PMID: 36302555.
- Lee H, Gan B. Ferroptosis execution: Is it all about ACSL4?. Cell Chem Biol 29(9):1363-1365, 2022. e-Pub 2022. PMID: 36113403.
- Dasgupta S, Gan B. Ferroptosis vulnerability in MYCN-driven neuroblastomas. Clin Transl Med 12(8):e963, 2022. e-Pub 2022. PMID: 35908258.
- Mao C, Gan B. Navigating ferroptosis via an NADPH sensor. Nat Cell Biol 24(8):1186-1187, 2022. e-Pub 2022. PMID: 35941366.
- Subbiah V, Gan B. Targeting Ferroptosis Vulnerability in Synovial Sarcoma: Is It All About ME1?. Clin Cancer Res 28(16):3408-3410, 2022. e-Pub 2022. PMID: 35727698.
- Lei G, Horbath A, Li Z, Gan B. PKCβII-ACSL4 pathway mediating ferroptosis execution and anti-tumor immunity. Cancer Commun (Lond) 42(7):583-586, 2022. e-Pub 2022. PMID: 35674490.
- Lei G, Zhuang L, Gan B. Targeting ferroptosis as a vulnerability in cancer. Nat Rev Cancer 22(7):381-396, 2022. e-Pub 2022. PMID: 35338310.
- Wu S, Mao C, Kondiparthi L, Poyurovsky MV, Olszewski K, Gan B. A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria. Proc Natl Acad Sci U S A 119(26):e2121987119, 2022. e-Pub 2022. PMID: 35749365.
- Mao C, Lei G, Zhuang L, Gan B. Ferroptosis as an important driver of lupus. Protein Cell 13(5):313-315, 2022. e-Pub 2022. PMID: 34826064.
- Koppula P, Lei G, Zhang Y, Yan Y, Mao C, Kondiparthi L, Shi J, Liu X, Horbath A, Das M, Li W, Poyurovsky MV, Olszewski K, Gan B. A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers. Nat Commun 13(1):2206, 2022. e-Pub 2022. PMID: 35459868.
- Gan B. ACSL4, PUFA, and ferroptosis: new arsenal in anti-tumor immunity. Signal Transduct Target Ther 7(1):128, 2022. e-Pub 2022. PMID: 35459217.
- Lei G, Gan B. Iron out KRAS-driven cancer. J Exp Med 219(4), 2022. e-Pub 2022. PMID: 35262627.
- Mao C, Lei G, Horbath A, Gan B. Assessment of lipid peroxidation in irradiated cells. Methods Cell Biol 172:37-50, 2022. e-Pub 2022. PMID: 36064225.
- Liu X, Koppula P, Olszewski K, Gan B. Thiol profiling in cancer cell lines by HPLC-mass spectrometry. STAR Protoc 2(4):100977, 2021. e-Pub 2021. PMID: 34917974.
- Song S, Chen Q, Li Y, Lei G, Scott A, Huo L, Li CY, Estrella JS, Correa A, Pizzi MP, Ma L, Jin J, Liu B, Wang Y, Xiao L, Hofstetter WL, Lee JH, Weston B, Bhutani M, Shanbhag N, Johnson RL, Gan B, Wei S, Ajani JA. Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma. Gut 70(12):2238-2248, 2021. e-Pub 2021. PMID: 33487592.
- Yao F, Deng Y, Zhao Y, Mei Y, Zhang Y, Liu X, Martinez C, Su X, Rosato RR, Teng H, Hang Q, Yap S, Chen D, Wang Y, Chen MM, Zhang M, Liang H, Xie D, Chen X, Zhu H, Chang JC, You MJ, Sun Y, Gan B, Ma L. A targetable LIFR-NF-κB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis. Nat Commun 12(1):7333, 2021. e-Pub 2021. PMID: 34921145.
- Mao C, Lei G, Zhuang L, Gan B. Phospholipase iPLA2β acts as a guardian against ferroptosis. Cancer Commun (Lond) 41(11):1082-1085, 2021. e-Pub 2021. PMID: 34657380.
- Lei G, Mao C, Yan Y, Zhuang L, Gan B. Ferroptosis, radiotherapy, and combination therapeutic strategies. Protein Cell 12(11):836-857, 2021. e-Pub 2021. PMID: 33891303.
- Liu X, Zhang Y, Zhuang L, Olszewski K, Gan B. NADPH debt drives redox bankruptcy: SLC7A11/xCT-mediated cystine uptake as a double-edged sword in cellular redox regulation. Genes Dis 8(6):731-745, 2021. e-Pub 2021. PMID: 34522704.
- Koppula P, Zhuang L, Gan B. Cytochrome P450 reductase (POR) as a ferroptosis fuel. Protein Cell 12(9):675-679, 2021. e-Pub 2021. PMID: 33539003.
- Gan B. Mitochondrial regulation of ferroptosis. J Cell Biol 220(9), 2021. e-Pub 2021. PMID: 34328510.
- Koppula P, Zhuang L, Gan B. Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy. Protein Cell 12(8):599-620, 2021. e-Pub 2021. PMID: 33000412.
- Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, Koppula P, Wu S, Zhuang L, Fang B, Poyurovsky MV, Olszewski K, Gan B. Author Correction: DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature 596(7873):E13, 2021. e-Pub 2021. PMID: 34341547.
- Lee H, Zhuang L, Gan B. Ether phospholipids govern ferroptosis. J Genet Genomics 48(7):S1673-8527(21)00132-6, 2021. e-Pub 2021. PMID: 34167916.
- Koppula P, Olszewski K, Zhang Y, Kondiparthi L, Liu X, Lei G, Das M, Fang B, Poyurovsky MV, Gan B. KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition. iScience 24(6):24(6):102649, 2021. e-Pub 2021. PMID: 34151236.
- Lei G, Zhang Y, Hong T, Zhang X, Liu X, Mao C, Yan Y, Koppula P, Cheng W, Sood AK, Liu J, Gan B. Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity. Oncogene 40(20):3533-3547, 2021. e-Pub 2021. PMID: 33927351.
- Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, Koppula P, Wu S, Zhuang L, Fang B, Poyurovsky M, Olszewski K, Gan B. DHODH-mediated ferroptosis defence is targetable in cancer. Nature 593(7860):593(7860):586-590, 2021. e-Pub 2021. PMID: 33981038.
- Zhang Y, Swanda RV, Nie L, Liu X, Wang C, Lee H, Lei G, Mao C, Koppula P, Cheng W, Zhang J, Xiao Z, Zhuang L, Fang B, Chen J, Qian SB, Gan B. mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation. Nat Commun 12(1):1589, 2021. e-Pub 2021. PMID: 33707434.
- Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, ÉMC Á, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, Ávalos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, Á B, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Barilà D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano E, Bel S, B. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy 17(1):1-382, 2021. e-Pub 2021. PMID: 33634751.
- Shen X, Wang R, Kim MJ, Hu Q, Hsu CC, Yao J, Klages-Mundt N, Tian Y, Lynn E, Brewer TF, Zhang Y, Arun B, Gan B, Andreeff M, Takeda S, Chen J, Park JI, Shi X, Chang CJ, Jung SY, Qin J, Li L. A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia. Mol Cell 80(6):1013-1024.e6, 2020. e-Pub 2020. PMID: 33338401.
- Zhang Y, Shi J, Liu X, Xiao Z, Lei G, Lee H, Koppula P, Cheng W, Mao C, Zhuang L, Ma L, Li W, Gan B. H2A monoubiquitination links glucose availability to epigenetic regulation of the endoplasmic reticulum stress response and cancer cell death. Cancer Res 80(11):2243-2256, 2020. e-Pub 2020. PMID: 32273282.
- Liu X, Olszewski K, Zhang Y, Lim EW, Shi J, Zhang X, Zhang J, Lee H, Koppula P, Lei G, Zhuang L, You MJ, Fang B, Li W, Metallo CM, Poyurovsky MV, Gan B. Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer. Nat Cell Biol 22(4):476-486, 2020. e-Pub 2020. PMID: 32231310.
- Chauhan AS, Zhuang L, Gan B. Spatial control of AMPK signaling at subcellular compartments. Crit Rev Biochem Mol Biol 55(1):17-32, 2020. e-Pub 2020. PMID: 32069425.
- Lei G, Zhang Y, Koppula P, Liu X, Zhang J, Lin SH, Ajani JA, Xiao Q, Liao Z, Wang H, Gan B. The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression. Cell Res 30(2):146-162, 2020. e-Pub 2020. PMID: 31949285.
- Lee H, Zandkarimi F, Zhang Y, Meena JK, Kim J, Zhuang L, Tyagi S, Ma L, Westbrook TF, Steinberg GR, Nakada D, Stockwell BR, Gan B. Energy-stress-mediated AMPK activation inhibits ferroptosis. Nat Cell Biol 22(2):225-234, 2020. e-Pub 2020. PMID: 32029897.
- Lee H, Zhuang L, Gan B. Energy stress inhibits ferroptosis via AMPK. Mol Cell Oncol 7(4):1761242, 2020. e-Pub 2020. PMID: 32944623.
- Chauhan AS, Zhuang L, Gan B. Antagonism between Antiviral Signaling and Glycolysis. Trends Endocrinol Metab 30(9):571-573, 2019. e-Pub 2019. PMID: 31349923.
- Gan B. DUBbing Ferroptosis in Cancer Cells. Cancer Res 79(8):1749-1750, 2019. e-Pub 2019. PMID: 30987975.
- Zhang Y, Koppula P, Gan B. Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1. Cell Cycle 18(8):773-783, 2019. e-Pub 2019. PMID: 30907299.
- Chauhan AS, Liu X, Jing J, Lee H, Yadav RK, Liu J, Zhou Y, Gan B. STIM2 interacts with AMPK and regulates calcium-induced AMPK activation. FASEB J 33(2):fj201801225R, 2019. e-Pub 2019. PMID: 30335546.
- Zhang Y, Zhuang L, Gan B. BAP1 suppresses tumor development by inducing ferroptosis upon SLC7A11 repression. Mol Cell Oncol 6(1):1536845, 2019. e-Pub 2019. PMID: 30788415.
- Kim J, Piao HL, Kim BJ, Yao F, Han Z, Wang Y, Xiao Z, Siverly AN, Lawhon SE, Ton BN, Lee H, Zhou Z, Gan B, Nakagawa S, Ellis MJ, Liang H, Hung MC, You MJ, Sun Y, Ma L. Long noncoding RNA MALAT1 suppresses breast cancer metastasis. Nat Genet 50(12):1705-1715, 2018. e-Pub 2018. PMID: 30349115.
- Zhang Y, Shi J, Liu X, Feng L, Gong Z, Koppula P, Sirohi K, Li X, Wei Y, Lee H, Zhuang L, Chen G, Xiao ZD, Hung MC, Chen J, Huang P, Li W, Gan B. BAP1 links metabolic regulation of ferroptosis to tumour suppression. Nat Cell Biol 20(10):1181-1192, 2018. e-Pub 2018. PMID: 30202049.
- Xiao ZD, Han L, Lee H, Zhuang L, Zhang Y, Baddour J, Nagrath D, Wood CG, Gu J, Wu X, Liang H, Gan B. Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development. Nat Commun 8(1):783, 2017. e-Pub 2017. PMID: 28978906.
- Koppula P, Zhang Y, Shi J, Li W, Gan B. The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate. J Biol Chem 292(34):14240-14249, 2017. e-Pub 2017. PMID: 28630042.
- Jonasch E, Hasanov E, Corn P, Moss T, Shaw K, Stovall S, Marcott V, Gan B, Bird S, Wang X, Do K, Altamirano P, Zurita A, Doyle L, Lara P, Tannir NM. A Randomized Phase 2 Study of MK-2206 versus Everolimus in Refractory Renal Cell Carcinoma. Ann Oncol 28(4):804-808, 2017. e-Pub 2017. PMID: 28049139.
- Dai F, Lee H, Zhang Y, Zhuang L, Yao H, Xi Y, Xiao ZD, You MJ, Li W, Su X, Gan B. BAP1 inhibits the ER stress gene regulatory network and modulates metabolic stress response. Proc Natl Acad Sci U S A 114(12):3192-3197, 2017. e-Pub 2017. PMID: 28275095.
- Liu X, Gan B. lncRNA NBR2 modulates cancer cell sensitivity to phenformin through GLUT1. Cell Cycle 15(24):3471-3481, 2016. e-Pub 2016. PMID: 27792451.
- Kim J, Siverly AN, Chen D, Wang M, Yuan Y, Wang Y, Lee H, Zhang J, Muller WJ, Liang H, Gan B, Yang X, Sun Y, You MJ, Ma L. Ablation of miR-10b Suppresses Oncogene-Induced Mammary Tumorigenesis and Metastasis and Reactivates Tumor-Suppressive Pathways. Cancer Res 76(21):6424-6435, 2016. e-Pub 2016. PMID: 27569213.
- Xiao ZD, Zhuang L, Gan B. Long non-coding RNAs in cancer metabolism. Bioessays 38(10):991-6, 2016. e-Pub 2016. PMID: 27550823.
- Liu X, Xiao ZD, Gan B. An lncRNA switch for AMPK activation. Cell Cycle May 6:1-2(15):1948-9, 2016. e-Pub 2016. PMID: 27152502.
- Xiao ZD, Liu X, Zhuang L, Gan B. NBR2: a former junk gene emerges as a key player in tumor suppression. Mol Cell Oncol 3(4):e1187322, 2016. e-Pub 2016. PMID: 27652330.
- Lee H, Dai F, Zhuang L, Xiao ZD, Kim J, Zhang Y, Ma L, You MJ, Wang Z, Gan B. BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21. Oncotarget 7(15):19134-19146, 2016. e-Pub 2016. PMID: 26992241.
- Liu X, Xiao ZD, Han L, Zhang J, Lee SW, Wang W, Lee H, Zhuang L, Chen J, Lin HK, Wang J, Liang H, Gan B. lncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. Nat Cell Biol 18(4):431-42, 2016. e-Pub 2016. PMID: 26999735.
- Wang W, Xiao ZD, Li X, Aziz KE, Gan B, Johnson RL, Chen J. AMPK modulates Hippo pathway activity to regulate energy homeostasis. Nature Cell Biology 17(4):490-9, 2015. e-Pub 2015.
- Wang W, Xiao ZD, Li X, Aziz KE, Gan B, Johnson RL, Chen J. AMPK modulates Hippo pathway activity to regulate energy homeostasis. Nat Cell Biol 17(4):490-9, 2015. e-Pub 2015. PMID: 25751139.
- Lin A, Yao J, Zhuang L, Wang D, Han J, Lam EW, Network TR, Gan B. The FoxO-BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress. Oncogene 33(24):3183-94, 2014. e-Pub 2014. PMID: 23851496.
- Lin A, Piao HL, Zhuang L, Sarbassov dos D, Ma L, Gan B. FoxO transcription factors promote AKT Ser473 phosphorylation and renal tumor growth in response to pharmacological inhibition of the PI3K-AKT pathway. Cancer Res 74(6):1682-93, 2014. e-Pub 2014. PMID: 24448243.
- Hu J, Ho AL, Yuan L, Hu B, Hua S, Hwang SS, Zhang J, Hu T, Zheng H, Gan B, Wu G, Wang YA, Chin L, DePinho RA. Neutralization of terminal differentiation in gliomagenesis. Proc Natl Acad Sci U S A 110(36):14520-7, 2013. e-Pub 2013. PMID: 23918370.
- Rosborough BR, Raïch-Regué D, Matta BM, Lee K, Gan B, DePinho RA, Hackstein H, Boothby M, Turnquist HR, Thomson AW. Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1 and regulatory T cell induction. Blood 121(18):3619-30, 2013. e-Pub 2013. PMID: 23444404.
- Keniry M, Pires MM, Mense S, Lefebvre C, Gan B, Justiano K, Lau YK, Hopkins B, Hodakoski C, Koujak S, Toole J, Fenton F, Calahan A, Califano A, DePinho RA, Maurer M, Parsons R. Survival factor NFIL3 restricts FOXO-induced gene expression in cancer. Genes Dev 27(8):916-27, 2013. e-Pub 2013. PMID: 23630076.
- Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, Paik JH, Lim C, Guimaraes AR, Martin ES, Chang J, Hezel AF, Perry SR, Hu J, Gan B, Xiao Y, Asara JM, Weissleder R, Wang YA, Chin L, Cantley LC, Depinho RA. Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism. Cell 149(3):656-70, 2012. e-Pub 2012. PMID: 22541435.
- Ding Z, Wu CJ, Jaskelioff M, Ivanova E, Kost-Alimova M, Protopopov A, Chu GC, Wang G, Lu X, Labrot ES, Hu J, Wang W, Xiao Y, Zhang H, Zhang J, Zhang J, Gan B, Perry SR, Jiang S, Li L, Horner JW, Wang YA, Chin L, DePinho RA. Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases. Cell 148(5):896-907, 2012. e-Pub 2012. PMID: 22341455.
- Hu J, Hwang SS, Liesa M, Gan B, Sahin E, Jaskelioff M, Ding Z, Ying H, Boutin AT, Zhang H, Johnson S, Ivanova E, Kost-Alimova M, Protopopov A, Wang YA, Shirihai OS, Chin L, DePinho RA. Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell 148(4):651-63, 2012. e-Pub 2012. PMID: 22341440.
- Zhang K, Li L, Qi Y, Zhu X, Gan B, DePinho RA, Averitt T, Guo S. Hepatic Suppression of Foxo1 and Foxo3 Causes Hypoglycemia and Hyperlipidemia in Mice. Endocrinology 153(2):631-46, 2012. e-Pub 2012. PMID: 22147007.
- Wei H, Wei S, Gan B, Peng X, Zou W, Guan JL. Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. Genes and Development 25(14):1510-1527, 2011. e-Pub 2011. PMID: 21764854.
- Gan B, Hu J, Jiang S, Liu Y, Sahin E, Zhuang L, Fletcher-Sananikone E, Colla S, Wang YA, Chin L, Depinho RA. Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature 468(7324):701-4, 2010. e-Pub 2010. PMID: 21124456.
- Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, Hu J, Vinjamoori A, Gan B, Sahin E, Chheda MG, Brennan C, Wang YA, Hahn WC, Chin L, DePinho RA. PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell 17(5):497-509, 2010. e-Pub 2010. PMID: 20478531.
- Liang CC, Wang C, Peng X, Gan B, Guan JL. Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration. J Biol Chem 285(5):3499-3509, 2010. e-Pub 2010. PMID: 19940130.
- Gan B, Lim C, Chu G, Hua S, Ding Z, Collins M, Hu J, Jiang S, Fletcher-Sananikone E, Zhuang L, Chang M, Zheng H, Wang YA, Kwiatkowski DJ, Jr KW, Signoretti S, DePinho RA. FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis. Cancer Cell 18(5):472-484, 2010. e-Pub 2010. PMID: 21075312.
- Wei H, Gan B, Wu X, Guan JL. Inactivation of FIP200 leads to inflammatory skin disorder, but not tumorigenesis, in conditional knock-out mouse models. J Biol Chem 284(9):6004-13, 2009. e-Pub 2009. PMID: 19106106.
- Wei H, Gan B, Wu X, Guan JL. Inactivation of FIP200 leads to inflammatory skin disorder, but not tumorigenesis, in conditional knock-out mouse models. Journal of Biological Chemistry 284(9):6004-6013, 2009. e-Pub 2009.
- Gan B, Sahin E, Jiang S, Sanchez-Aguilera A, Scott KL, Chin L, Williams DA, Kwiatkowski DJ, DePinho RA. mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proc Natl Acad Sci U S A 105(49):19384-9, 2008. e-Pub 2008. PMID: 19052232.
- Martin N, Schwamborn K, Urlaub H, Gan B, Guan JL, Dejean A. Spatial interplay between PIASy and FIP200 in the regulation of signal transduction and transcriptional activity. Mol Cell Biol 28(8):2771-2781, 2008. e-Pub 2008. PMID: 18285457.
- Nagy T, Wei H, Shen TL, Peng X, Liang CC, Gan B, Guan JL. Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine mammary gland. J Biol Chem 282(43):31766, 2007. e-Pub 2007. PMID: 17716968.
- Gan B, Yoo Y, Guan JL. Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth. J Biol Chem 281(49):37321-37329, 2006. e-Pub 2006. PMID: 17043358.
- Gan B, Peng X, Nagy T, Alcaraz A, Gu H, Guan JL. Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways. J Cell Biol 175(1):121-133, 2006. e-Pub 2006. PMID: 17015619.
- Wei H, Wang X, Gan B, Urvalek AM, Melkoumian ZK, Guan JL, Zhao J. Sumoylation delimits KLF8 transcriptional activity associated with the cell cycle regulation. J Biol Chem 281(24):16664-16671, 2006. e-Pub 2006. PMID: 16617055.
- Gan B, Melkoumian ZK, Wu X, Guan KL, Guan JL. Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control. J Cell Biol 170(3):379-389, 2005. e-Pub 2005. PMID: 16043512.
- Wu X, Gan B, Yoo Y, Guan JL. FAK-mediated src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation. Dev Cell 9(2):185-196, 2005. e-Pub 2005. PMID: 16054026.
- Melkoumian ZK, Peng X, Gan B, Wu X, Guan JL. Mechanism of cell cycle regulation by FIP200 in human breast cancer cells. Cancer Res 65(15):6676-6684, 2005. e-Pub 2005. PMID: 16061648.
Invited Articles
- Lei G, Zhuang L, Gan B. mTORC1 and ferroptosis: regulatory mechanisms and therapeutic potential. Bioessays 43(8):e2100093. doi: 10.1002/bies.202100093, 2021. e-Pub 2021. PMID: 34121197.
- Liu X, Gan B. Glucose starvation induces NADPH collapse and disulfide stress in SLC7A11 high cancer cells. Oncotarget 12(16):12(16):1629-1630, 2021. e-Pub 2021. PMID: 34381568.
- Yan Y, Lei G, Gan B. A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis. Molecular & Cellular Oncology:8(3):1919006, 2021. e-Pub 2021.
- Yadav RK, Chauhan AS, Zhuang L, Gan B. FoxO transcription factors in cancer metabolism. Semin Cancer Biol 50:65-76, 2018. e-Pub 2018. PMID: 29309929.
- Koppula P, Zhang Y, Zhuang L, Gan B. Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer. Cancer Commun (Lond) 38(12):12, 2018. e-Pub 2018. PMID: 29764521.
- Zhang Y, Gan B, Liu D, Paik JH. FoxO family members in cancer. Cancer Biol Ther 12(4):253-259, 2011. e-Pub 2011. PMID: 21613825.
- Gan B, DePinho RA. mTORC1 signaling governs hematopoietic stem cell quiescence. Cell Cycle 8(7):1003-1006, 2009. e-Pub 2009. PMID: 19270523.
- Gan B, Guan JL. FIP200, a key signaling node to coordinately regulate various cellular processes. Cell Signal 20(5):787-94, 2008. e-Pub 2008. PMID: 18036779.
Other Articles
- Yan, Y, Lei, G, Gan, B A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis. Molecular and Cellular Oncology 8(3), 2021. PMID: 34027051.
Patents
- Gan B, Yan Y. Methods for Inducing Ferroptosis in Cancer. Patent Number: 63/452,358.
- Gan B, Lei G. Compositions and methods of targeting subjects with BRCA1 mutation and deficiency. Patent Number: 63/378,651.
Patient Reviews
CV information above last modified June 26, 2025