Boyi Gan, Ph.D.
Department of Experimental Radiation Oncology, Division of Radiation Oncology
Present Title & Affiliation
Primary Appointment
Professor, Department of Experimental Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Director, Radiation and Cancer Metabolism Research Program, MD Anderson Cancer Center, Houston, TX
N.G. and Hellen T. Hawkins Distinguished Professor for Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
Metabolic Regulation of Ferroptosis, Nutrient Dependency, and Tumor Suppression
Our lab studies the life and death of cells under metabolic stress conditions, and aims to translate such fundamental studies into development of novel effective cancer therapies. Our previous studies focused on the FoxO/TSC/LKB1 tumor suppressor network, and have delineated an intimate link between tumor suppressor pathways that control energy sensing/metabolism and those that regulate stem cell homeostasis ( PNAS, 2008; Cancer Cell, 2010; Nature, 2010 ), and identified critical mechanisms on how cancer cells adapt to metabolic stress or cancer therapy ( Cancer Research, 2014; Nature Cell Biology, 2016; Nature Communications, 2017; PNAS, 2017 ).
Our current research focuses on two related research topics that have emerged from our more recent work: 1) the role and mechanisms of ferroptosis in cellular metabolism, tumor suppression, and cancer therapy. Our recent findings revealed that ferroptosis is an important tumor suppression mechanism and uncovered a critical role of ferroptosis in radiotherapy-induced cell death and tumor suppression, therefore providing a broad framework for further understanding and targeting ferroptosis in cancer therapy ( Nature Cell Biology, 2018; Cell Research, 2020; Nature Communications, 2021; Nature Cell Biology, 2020; Nature, 2021 ). 2) Cystine metabolism-induced nutrient dependency and its implication in cancer therapy. We recently showed that, in SLC7A11-high cancer cells, SLC7A11-assocated cystine metabolism induces disulfide stress and rapid cell death in glucose-limiting conditions, and proposed therapeutic strategies to target this metabolic vulnerability in SLC7A11-high cancers ( Nature Cell Biology, 2020; Cancer Research, 2020 ).
For more information, please visit our lab webpage: https://www.mdanderson.org/research/departments-labs-institutes/labs/gan-laboratory/research.html.
Education & Training
Degree-Granting Education
| 2006 | Cornell University, Ithaca, NY, USA, PHD, Comparative Biomedical Sciences |
| 2000 | Fudan University, Shanghai, CHN, MS, Genetics |
| 1997 | Fudan University, Shanghai, CHN, BS, Microbiology |
Postgraduate Training
| 2010-2011 | Instructor, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA |
| 2006-2010 | Postdoctoral Fellow, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA |
Honors & Awards
| 2023 | N.G. and Hellen T. Hawkins Distinguished Professor for Cancer Research, MD Anderson Cancer Center |
| 2022 | Honor to be highlighted in the Wall of Science, MD Anderson Cancer Center |
| 2022 | Faculty Honoree Award in Research Excellence, MD Anderson Cancer |
| 2021 | The Dallas/Fort Worth Living Legend Faculty Achievement Award in Basic Research |
| 2021 | Honor to be highlighted in the Wall of Science, MD Anderson Cancer Center |
| 2021 | Faculty Honoree Award in Research Excellence, MD Anderson Cancer Center |
| 2020 | Faculty Honoree Award in Research Excellence, MD Anderson Cancer Center |
| 2018 | MD Anderson Faculty Scholar Award, MD Anderson Cancer Center |
| 2017 | Andrew Sabin Family Award, MD Anderson Cancer Center |
| 2016 | Anna Fuller Foundation Award, Anna Fuller Foundation |
| 2013 | Gabrielle's Angel Foundation Award, Gabrielle's Angel Foundation for Cancer Research |
| 2013 | Ellison Medical Foundation New Scholar Award, Ellison Medical Foundation |
| 2012 | The LAM Foundation Pilot Award, The LAM Foundation |
| 2012 | Kimmel Scholar, Sidney Kimmel Foundation |
| 2012 | CONquer canCER Now Award, Concern Foundation |
| 2012 | CSCDB Faculty Scholar Award, Center for Stem Cell and Developmental Biology, UT MD Anderson Cancer Center |
| 2011 | DOD PCRP Exploration - Hypothesis Development Award, Department of Defense |
| 2011 | Harvard Chinese Life Science Annual Distinguished Research Award |
| 2011 | MDACC Trust Scholar, MD Anderson Cancer Center |
| 2011 | STARS Award, University of Texas |
| 2010 | DOD TSCRP Career Transition Award, Department of Defense |
| 2009 | DF/HCC Kidney Cancer SPORE Career Development Award, DF/HCC Kidney Cancer SPORE |
| 2007 | Leukemia & Lymphoma Society Fellowship, Leukemia & Lymphoma Society |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Liu X, Nie L, Zhang Y, Yan Y, Wang C, Colic M, Olszewski K, Horbath A, Chen X, Lei G, Mao C, Wu S, Zhuang L, Poyurovsky MV, James You M, Hart T, Billadeau DD, Chen J, Gan B. Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis. Nat Cell Biol 25(3):404-414, 2023. e-Pub 2023. PMID: 36747082.
- Gan B. How erastin assassinates cells by ferroptosis revealed. Protein Cell 14(2):84-86, 2023. PMID: 36929006.
- Gan B. Ferroptosis hijacking by Mycobacterium tuberculosis. Nat Commun 14(1):1431, 2023. e-Pub 2023. PMID: 36932073.
- Lee H, Gan B. Ferroptosis execution: Is it all about ACSL4?. Cell Chem Biol 29(9):1363-1365, 2022. PMID: 36113403.
- Nie L, Wang C, Liu X, Teng H, Li S, Huang M, Feng X, Pei G, Hang Q, Zhao Z, Gan B, Ma L, Chen J. USP7 substrates identified by proteomics analysis reveal the specificity of USP7. Genes Dev 36(17-18):1016-1030, 2022. e-Pub 2022. PMID: 36302555.
- Dasgupta S, Gan B. Ferroptosis vulnerability in MYCN-driven neuroblastomas. Clin Transl Med 12(8):e963, 2022. PMID: 35908258.
- Mao C, Gan B. Navigating ferroptosis via an NADPH sensor. Nat Cell Biol 24(8):1186-1187, 2022. PMID: 35941366.
- Subbiah V, Gan B. Targeting Ferroptosis Vulnerability in Synovial Sarcoma: Is It All About ME1?. Clin Cancer Res 28(16):3408-3410, 2022. PMID: 35727698.
- Lei G, Zhuang L, Gan B. Targeting ferroptosis as a vulnerability in cancer. Nat Rev Cancer 22(7):381-396, 2022. e-Pub 2022. PMID: 35338310.
- Lei G, Horbath A, Li Z, Gan B. PKCβII-ACSL4 pathway mediating ferroptosis execution and anti-tumor immunity. Cancer Commun (Lond) 42(7):583-586, 2022. e-Pub 2022. PMID: 35674490.
- Wu S, Mao C, Kondiparthi L, Poyurovsky MV, Olszewski K, Gan B. A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria. Proc Natl Acad Sci U S A 119(26):e2121987119, 2022. e-Pub 2022. PMID: 35749365.
- Mao C, Lei G, Zhuang L, Gan B. Ferroptosis as an important driver of lupus. Protein Cell 13(5):313-315, 2022. e-Pub 2021. PMID: 34826064.
- Lei G, Gan B. Iron out KRAS-driven cancer. J Exp Med 219(4), 2022. e-Pub 2022. PMID: 35262627.
- Gan B. ACSL4, PUFA, and ferroptosis: new arsenal in anti-tumor immunity. Signal Transduct Target Ther 7(1):128, 2022. e-Pub 2022. PMID: 35459217.
- Koppula P, Lei G, Zhang Y, Yan Y, Mao C, Kondiparthi L, Shi J, Liu X, Horbath A, Das M, Li W, Poyurovsky MV, Olszewski K, Gan B. A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers. Nat Commun 13(1):2206, 2022. e-Pub 2022. PMID: 35459868.
- Mao C, Lei G, Horbath A, Gan B. Assessment of lipid peroxidation in irradiated cells. Methods Cell Biol 172:37-50, 2022. e-Pub 2022. PMID: 36064225.
- Song S, Chen Q, Li Y, Lei G, Scott A, Huo L, Li CY, Estrella JS, Correa A, Pizzi MP, Ma L, Jin J, Liu B, Wang Y, Xiao L, Hofstetter WL, Lee JH, Weston B, Bhutani M, Shanbhag N, Johnson RL, Gan B, Wei S, Ajani JA. Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma. Gut 70(12):2238-2248, 2021. e-Pub 2021. PMID: 33487592.
- Liu X, Koppula P, Olszewski K, Gan B. Thiol profiling in cancer cell lines by HPLC-mass spectrometry. STAR Protoc 2(4):100977, 2021. e-Pub 2021. PMID: 34917974.
- Yao F, Deng Y, Zhao Y, Mei Y, Zhang Y, Liu X, Martinez C, Su X, Rosato RR, Teng H, Hang Q, Yap S, Chen D, Wang Y, Chen MM, Zhang M, Liang H, Xie D, Chen X, Zhu H, Chang JC, You MJ, Sun Y, Gan B, Ma L. A targetable LIFR-NF-κB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis. Nat Commun 12(1):7333, 2021. e-Pub 2021. PMID: 34921145.
- Lei G, Mao C, Yan Y, Zhuang L, Gan B. Ferroptosis, radiotherapy, and combination therapeutic strategies. Protein Cell 12(11):836-857, 2021. e-Pub 2021. PMID: 33891303.
- Liu X, Zhang Y, Zhuang L, Olszewski K, Gan B. NADPH debt drives redox bankruptcy: SLC7A11/xCT-mediated cystine uptake as a double-edged sword in cellular redox regulation. Genes Dis 8(6):731-745, 2021. e-Pub 2020. PMID: 34522704.
- Mao C, Lei G, Zhuang L, Gan B. Phospholipase iPLA2β acts as a guardian against ferroptosis. Cancer Commun (Lond) 41(11):1082-1085, 2021. e-Pub 2021. PMID: 34657380.
- Gan B. Mitochondrial regulation of ferroptosis. J Cell Biol 220(9), 2021. e-Pub 2021. PMID: 34328510.
- Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, Koppula P, Wu S, Zhuang L, Fang B, Poyurovsky MV, Olszewski K, Gan B. Author Correction: DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature 596(7873):E13, 2021. PMID: 34341547.
- Lee H, Zhuang L, Gan B. Ether phospholipids govern ferroptosis. J Genet Genomics:S1673-8527(21)00132-6. e-Pub 2021. PMID: 34167916.
- Koppula P, Olszewski K, Zhang Y, Kondiparthi L, Liu X, Lei G, Das M, Fang B, Poyurovsky MV, Gan B. KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition. iScience 24(6):24(6):102649, 2021. e-Pub 2021. PMID: 34151236.
- Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, Koppula P, Wu S, Zhuang L, Fang B, Poyurovsky M, Olszewski K, Gan B. DHODH-mediated ferroptosis defence is targetable in cancer. Nature:593(7860):586-590, 2021. PMID: 33981038.
- Lei G, Zhang Y, Hong T, Zhang X, Liu X, Mao C, Yan Y, Koppula P, Cheng W, Sood AK, Liu J, Gan B. Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity. Oncogene. e-Pub 2021. PMID: 33927351.
- Zhang Y, Swanda RV, Nie L, Liu X, Wang C, Lee H, Lei G, Mao C, Koppula P, Cheng W, Zhang J, Xiao Z, Zhuang L, Fang B, Chen J, Qian SB, Gan B. mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation. Nat Commun 12(1):1589, 2021. e-Pub 2021. PMID: 33707434.
- Koppula P, Zhuang L, Gan B. Cytochrome P450 reductase (POR) as a ferroptosis fuel. Protein Cell. e-Pub 2021. PMID: 33539003.
- Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, Ávalos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, Bánréti Á, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Barilà D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano E, Bel S, B. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy 17(1):1-382, 2021. e-Pub 2021. PMID: 33634751.
- Shen X, Wang R, Kim MJ, Hu Q, Hsu CC, Yao J, Klages-Mundt N, Tian Y, Lynn E, Brewer TF, Zhang Y, Arun B, Gan B, Andreeff M, Takeda S, Chen J, Park JI, Shi X, Chang CJ, Jung SY, Qin J, Li L. A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia. Mol Cell 80(6):1013-1024.e6, 2020. PMID: 33338401.
- Koppula P, Zhuang L, Gan B. Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy. Protein Cell. e-Pub 2020. PMID: 33000412.
- Zhang Y, Shi J, Liu X, Xiao Z, Lei G, Lee H, Koppula P, Cheng W, Mao C, Zhuang L, Ma L, Li W, Gan B. H2A monoubiquitination links glucose availability to epigenetic regulation of the endoplasmic reticulum stress response and cancer cell death. Cancer Res 80(11):2243-2256, 2020. e-Pub 2020. PMID: 32273282.
- Liu X, Olszewski K, Zhang Y, Lim EW, Shi J, Zhang X, Zhang J, Lee H, Koppula P, Lei G, Zhuang L, You MJ, Fang B, Li W, Metallo CM, Poyurovsky MV, Gan B. Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer. Nat Cell Biol 22(4):476-486, 2020. e-Pub 2020. PMID: 32231310.
- Lei G, Zhang Y, Koppula P, Liu X, Zhang J, Lin SH, Ajani JA, Xiao Q, Liao Z, Wang H, Gan B. The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression. Cell Res 30(2):146-162, 2020. e-Pub 2020. PMID: 31949285.
- Lee H, Zandkarimi F, Zhang Y, Meena JK, Kim J, Zhuang L, Tyagi S, Ma L, Westbrook TF, Steinberg GR, Nakada D, Stockwell BR, Gan B. Energy-stress-mediated AMPK activation inhibits ferroptosis. Nat Cell Biol 22(2):225-234, 2020. e-Pub 2020. PMID: 32029897.
- Chauhan AS, Zhuang L, Gan B. Spatial control of AMPK signaling at subcellular compartments. Crit Rev Biochem Mol Biol 55(1):17-32, 2020. e-Pub 2020. PMID: 32069425.
- Lee H, Zhuang L, Gan B. Energy stress inhibits ferroptosis via AMPK. Mol Cell Oncol 7(4):1761242, 2020. e-Pub 2020. PMID: 32944623.
- Chauhan AS, Zhuang L, Gan B. Antagonism between Antiviral Signaling and Glycolysis. Trends Endocrinol Metab 30(9):571-573, 2019. e-Pub 2019. PMID: 31349923.
- Zhang Y, Koppula P, Gan B. Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1. Cell Cycle 18(8):773-783, 2019. e-Pub 2019. PMID: 30907299.
- Gan B. DUBbing Ferroptosis in Cancer Cells. Cancer Res 79(8):1749-1750, 2019. PMID: 30987975.
- Chauhan AS, Liu X, Jing J, Lee H, Yadav RK, Liu J, Zhou Y, Gan B. STIM2 interacts with AMPK and regulates calcium-induced AMPK activation. FASEB J 33(2):fj201801225R, 2019. e-Pub 2018. PMID: 30335546.
- Zhang Y, Zhuang L, Gan B. BAP1 suppresses tumor development by inducing ferroptosis upon SLC7A11 repression. Mol Cell Oncol 6(1):1536845, 2019. e-Pub 2018. PMID: 30788415.
- Kim J, Piao HL, Kim BJ, Yao F, Han Z, Wang Y, Xiao Z, Siverly AN, Lawhon SE, Ton BN, Lee H, Zhou Z, Gan B, Nakagawa S, Ellis MJ, Liang H, Hung MC, You MJ, Sun Y, Ma L. Long noncoding RNA MALAT1 suppresses breast cancer metastasis. Nat Genet 50(12):1705-1715, 2018. e-Pub 2018. PMID: 30349115.
- Zhang Y, Shi J, Liu X, Feng L, Gong Z, Koppula P, Sirohi K, Li X, Wei Y, Lee H, Zhuang L, Chen G, Xiao ZD, Hung MC, Chen J, Huang P, Li W, Gan B. BAP1 links metabolic regulation of ferroptosis to tumour suppression. Nat Cell Biol 20(10):1181-1192, 2018. e-Pub 2018. PMID: 30202049.
- Xiao ZD, Han L, Lee H, Zhuang L, Zhang Y, Baddour J, Nagrath D, Wood CG, Gu J, Wu X, Liang H, Gan B. Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development. Nat Commun 8(1):783, 2017. e-Pub 2017. PMID: 28978906.
- Koppula P, Zhang Y, Shi J, Li W, Gan B. The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate. J Biol Chem 292(34):14240-14249, 2017. e-Pub 2017. PMID: 28630042.
- Jonasch E, Hasanov E, Corn P, Moss T, Shaw K, Stovall S, Marcott V, Gan B, Bird S, Wang X, Do K, Altamirano P, Zurita A, Doyle L, Lara P, Tannir NM. A Randomized Phase 2 Study of MK-2206 versus Everolimus in Refractory Renal Cell Carcinoma. Ann Oncol 28(4):804-808, 2017. e-Pub 2017. PMID: 28049139.
- Dai F, Lee H, Zhang Y, Zhuang L, Yao H, Xi Y, Xiao ZD, You MJ, Li W, Su X, Gan B. BAP1 inhibits the ER stress gene regulatory network and modulates metabolic stress response. Proc Natl Acad Sci U S A 114(12):3192-3197, 2017. e-Pub 2017. PMID: 28275095.
- Liu X, Gan B. lncRNA NBR2 modulates cancer cell sensitivity to phenformin through GLUT1. Cell Cycle 15(24):3471-3481, 2016. e-Pub 2016. PMID: 27792451.
- Kim J, Siverly AN, Chen D, Wang M, Yuan Y, Wang Y, Lee H, Zhang J, Muller WJ, Liang H, Gan B, Yang X, Sun Y, You MJ, Ma L. Ablation of miR-10b Suppresses Oncogene-Induced Mammary Tumorigenesis and Metastasis and Reactivates Tumor-Suppressive Pathways. Cancer Res 76(21):6424-6435, 2016. e-Pub 2016. PMID: 27569213.
- Xiao ZD, Zhuang L, Gan B. Long non-coding RNAs in cancer metabolism. Bioessays 38(10):991-6, 2016. e-Pub 2016. PMID: 27550823.
- Liu X, Xiao ZD, Gan B. An lncRNA switch for AMPK activation. Cell Cycle May 6:1-2(15):1948-9, 2016. e-Pub 2016. PMID: 27152502.
- Xiao ZD, Liu X, Zhuang L, Gan B. NBR2: a former junk gene emerges as a key player in tumor suppression. Mol Cell Oncol 3(4):e1187322, 2016. e-Pub 2016. PMID: 27652330.
- Liu X, Xiao ZD, Han L, Zhang J, Lee SW, Wang W, Lee H, Zhuang L, Chen J, Lin HK, Wang J, Liang H, Gan B. lncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. Nat Cell Biol 18(4):431-42, 2016. e-Pub 2016. PMID: 26999735.
- Lee H, Dai F, Zhuang L, Xiao ZD, Kim J, Zhang Y, Ma L, You MJ, Wang Z, Gan B. BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21. Oncotarget 7(15):19134-19146, 2016. e-Pub 2016. PMID: 26992241.
- Wang W, Xiao ZD, Li X, Aziz KE, Gan B, Johnson RL, Chen J. AMPK modulates Hippo pathway activity to regulate energy homeostasis. Nature Cell Biology 17(4):490-9, 2015.
- Lin A, Yao J, Zhuang L, Wang D, Han J, Lam EW, TCGA Research Network, Gan B. The FoxO-BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress. Oncogene 33(24):3183-94, 2014. e-Pub 2013. PMID: 23851496.
- Lin A, Piao HL, Zhuang L, Sarbassov dos D, Ma L, Gan B. FoxO transcription factors promote AKT Ser473 phosphorylation and renal tumor growth in response to pharmacological inhibition of the PI3K-AKT pathway. Cancer Res 74(6):1682-93, 2014. e-Pub 2014. PMID: 24448243.
- Hu J, Ho AL, Yuan L, Hu B, Hua S, Hwang SS, Zhang J, Hu T, Zheng H, Gan B, Wu G, Wang YA, Chin L, DePinho RA. Neutralization of terminal differentiation in gliomagenesis. Proc Natl Acad Sci U S A 110(36):14520-7, 2013. e-Pub 2013. PMID: 23918370.
- Rosborough BR, Raïch-Regué D, Matta BM, Lee K, Gan B, DePinho RA, Hackstein H, Boothby M, Turnquist HR, Thomson AW. Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1 and regulatory T cell induction. Blood 121(18):3619-30, 2013. e-Pub 2013. PMID: 23444404.
- Keniry M, Pires MM, Mense S, Lefebvre C, Gan B, Justiano K, Lau YK, Hopkins B, Hodakoski C, Koujak S, Toole J, Fenton F, Calahan A, Califano A, DePinho RA, Maurer M, Parsons R. Survival factor NFIL3 restricts FOXO-induced gene expression in cancer. Genes Dev 27(8):916-27, 2013. e-Pub 2013. PMID: 23630076.
- Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, Paik JH, Lim C, Guimaraes AR, Martin ES, Chang J, Hezel AF, Perry SR, Hu J, Gan B, Xiao Y, Asara JM, Weissleder R, Wang YA, Chin L, Cantley LC, Depinho RA. Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism. Cell 149(3):656-70, 2012. PMID: 22541435.
- Ding Z, Wu CJ, Jaskelioff M, Ivanova E, Kost-Alimova M, Protopopov A, Chu GC, Wang G, Lu X, Labrot ES, Hu J, Wang W, Xiao Y, Zhang H, Zhang J, Zhang J, Gan B, Perry SR, Jiang S, Li L, Horner JW, Wang YA, Chin L, DePinho RA. Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases. Cell 148(5):896-907, 2012. e-Pub 2012. PMID: 22341455.
- Zhang K, Li L, Qi Y, Zhu X, Gan B, DePinho RA, Averitt T, Guo S. Hepatic Suppression of Foxo1 and Foxo3 Causes Hypoglycemia and Hyperlipidemia in Mice. Endocrinology 153(2):631-46, 2012. e-Pub 2011. PMID: 22147007.
- Hu J, Hwang SS, Liesa M, Gan B, Sahin E, Jaskelioff M, Ding Z, Ying H, Boutin AT, Zhang H, Johnson S, Ivanova E, Kost-Alimova M, Protopopov A, Wang YA, Shirihai OS, Chin L, DePinho RA. Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell 148(4):651-63, 2012. PMID: 22341440.
- Wei H, Wei S, Gan B, Peng X, Zou W, Guan JL. Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. Genes and Development 25(14):1510-1527, 2011. PMID: 21764854.
- Gan B, Hu J, Jiang S, Liu Y, Sahin E, Zhuang L, Fletcher-Sananikone E, Colla S, Wang YA, Chin L, Depinho RA. Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature 468(7324):701-4, 2010. PMID: 21124456.
- Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, Hu J, Vinjamoori A, Gan B, Sahin E, Chheda MG, Brennan C, Wang YA, Hahn WC, Chin L, DePinho RA. PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell 17(5):497-509, 2010. PMID: 20478531.
- Liang CC, Wang C, Peng X, Gan B, Guan JL. Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration. J Biol Chem 285(5):3499-3509, 2010. e-Pub 2009. PMID: 19940130.
- Gan B, Lim C, Chu G, Hua S, Ding Z, Collins M, Hu J, Jiang S, Fletcher-Sananikone E, Zhuang L, Chang M, Zheng H, Wang YA, Kwiatkowski DJ, Kaelin WG Jr, Signoretti S, DePinho RA. FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis. Cancer Cell 18(5):472-484, 2010. PMID: 21075312.
- Wei H, Gan B, Wu X, Guan JL. Inactivation of FIP200 leads to inflammatory skin disorder, but not tumorigenesis, in conditional knock-out mouse models. Journal of Biological Chemistry 284(9):6004-6013, 2009.
- Gan B, Sahin E, Jiang S, Sanchez-Aguilera A, Scott KL, Chin L, Williams DA, Kwiatkowski DJ, DePinho RA. mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proc Natl Acad Sci U S A 105(49):19384-9, 2008. e-Pub 2008. PMID: 19052232.
- Martin N, Schwamborn K, Urlaub H, Gan B, Guan JL, Dejean A. Spatial interplay between PIASy and FIP200 in the regulation of signal transduction and transcriptional activity. Mol Cell Biol 28(8):2771-2781, 2008. e-Pub 2008. PMID: 18285457.
- Nagy T, Wei H, Shen TL, Peng X, Liang CC, Gan B, Guan JL. Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine mammary gland. J Biol Chem 282(43):31766, 2007. e-Pub 2007. PMID: 17716968.
- Gan B, Yoo Y, Guan JL. Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth. J Biol Chem 281(49):37321-37329, 2006. e-Pub 2006. PMID: 17043358.
- Gan B, Peng X, Nagy T, Alcaraz A, Gu H, Guan JL. Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways. J Cell Biol 175(1):121-133, 2006. e-Pub 2006. PMID: 17015619.
- Wei H, Wang X, Gan B, Urvalek AM, Melkoumian ZK, Guan JL, Zhao J. Sumoylation delimits KLF8 transcriptional activity associated with the cell cycle regulation. J Biol Chem 281(24):16664-16671, 2006. e-Pub 2006. PMID: 16617055.
- Gan B, Melkoumian ZK, Wu X, Guan KL, Guan JL. Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control. J Cell Biol 170(3):379-389, 2005. e-Pub 2005. PMID: 16043512.
- Melkoumian ZK, Peng X, Gan B, Wu X, Guan JL. Mechanism of cell cycle regulation by FIP200 in human breast cancer cells. Cancer Res 65(15):6676-6684, 2005. PMID: 16061648.
- Wu X, Gan B, Yoo Y, Guan JL. FAK-mediated src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation. Dev Cell 9(2):185-196, 2005. PMID: 16054026.
Invited Articles
- Lei G, Zhuang L, Gan B. mTORC1 and ferroptosis: regulatory mechanisms and therapeutic potential. Bioessays 43(8):e2100093. doi: 10.1002/bies.202100093, 2021. e-Pub 2021. PMID: 34121197.
- Liu X, Gan B. Glucose starvation induces NADPH collapse and disulfide stress in SLC7A11 high cancer cells. Oncotarget 12(16):12(16):1629-1630, 2021. e-Pub 2021. PMID: 34381568.
- Yan Y, Lei G, Gan B.. A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis. Molecular & Cellular Oncology:8(3):1919006, 2021.
- Yadav RK, Chauhan AS, Zhuang L, Gan B. FoxO transcription factors in cancer metabolism. Semin Cancer Biol 50:65-76, 2018. e-Pub 2018. PMID: 29309929.
- Koppula P, Zhang Y, Zhuang L, Gan B. Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer. Cancer Commun (Lond) 38(12):12, 2018. e-Pub 2018. PMID: 29764521.
- Zhang Y, Gan B, Liu D, Paik JH. FoxO family members in cancer. Cancer Biol Ther 12(4):253-259, 2011. e-Pub 2011. PMID: 21613825.
- Gan B, DePinho RA. mTORC1 signaling governs hematopoietic stem cell quiescence. Cell Cycle 8(7):1003-1006, 2009. e-Pub 2009. PMID: 19270523.
- Gan B, Guan JL. FIP200, a key signaling node to coordinately regulate various cellular processes. Cell Signal 20(5):787-94, 2008. e-Pub 2007. PMID: 18036779.