Caroline Chung, MD, MSc., FRCPC, CIP
Department of Radiation Oncology - Clinical, Division of Radiation Oncology Division
About Dr. Chung
Dr. Chung’s clinical practice includes the treatment of primary CNS malignancies, brain metastases and breast cancer. Her primary research interests have focused on personalized image-guided approaches for the management of brain tumors and metastases. Specifically, this includes the investigation of novel combinations of systemic therapy and radiosurgery for brain metastases and the evaluation of imaging biomarkers of both response and toxicity following treatment. With a translational approach, her preclinical work has included the investigation of conformal radiation in combination with targeted anti-angiogenic therapy in a murine intracranial brain tumor model with serial multiparametric MRI and biofluid measures to discover promising biomarkers of response to guide personalized treatment of brain tumors. The findings from this preclinical work has lead to several ongoing clinical trials evaluating serial MRI biomarkers in patients treated with radiosurgery as well as a Phase I dose-escalation trial of anti-angiogenic agent (Sunitinib) in concurrently with radiosurgery. In terms of image-guided therapy, Dr. Chung has also lead the early clinical evaluation of a novel image-guided Gamma Knife radiosurgery unit that incorporates cone-beam CT and infrared intrafraction motion-monitoring. In addition to tumor directed therapy, Dr. Chung is investigating imaging measures and potential treatments of radiation injury in the brain through her translational research and as the principal investigator of a multi-centred Phase II randomized clinical trial of bevacizumab + steroids vs. placebo + steroids through the Alliance for Clinical Trials in Oncology collaborative group.
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Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Director of Imaging Technology and Innovation, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Director of Advanced Imaging - Strategic Initiative, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Associate Professor, Department of Diagnostic Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Affiliate Scientist, Techna Institute University Health Network, Toronto
Education & Training
Degree-Granting Education
| 2011 | University of Toronto Institute of Medical Science, Toronto, CAN, MSc, Science |
| 2003 | The University of British Columbia, Vancouver, CAN, MD, MD |
| 1999 | The University of British Columbia, Vancouver, CAN, BSc, Biochemistry – Molecular Biology and Genetics |
Postgraduate Training
| 2008-2010 | Clinician Investigator Program, The University of British Columbia, Vancouver |
| 2008-2010 | Research Fellowship, Radiation Oncology, Princess Margaret Hospital, Toronto |
| 2003-2008 | Clinical Residency, Radiation Oncology, The University of British Columbia, Vancouver |
Experience & Service
Academic Appointments
Clinician-Scientist (cross-appointment), Division of Joint Division of Medical Imaging, University Health Network, Toronto, 2015 - 2016
Clinician-Scientist (cross-appointment), Department of Radiation Oncology, Division of Ontario Association of Radiation Oncologists, Ontario Association of Radiation Oncologists, Toronto, 2012 - 2016
Assistant Professor, Department of Faculty of Medicine, Division of Radiation Oncology, University of Toronto, Toronto, 2011 - 2016
Administrative Appointments/Responsibilities
Chief Fellow, Department of Radiation Oncology, University of Toronto, Princess Margaret Cancer Centre, Toronto, 2009 - 2010
Chief Resident, Department of Radiation Oncology, University of British Columbia, BC Cancer Agency, Vancouver, 2007 - 2008
Institutional Committee Activities
Co-Chair, Informatics Committee, 2016 - Present
Honors & Awards
| 2015 | Marquis Who’s Who in the World |
| 2015 | Research Productivity 2014/2015, Princess Margaret Cancer Centre |
| 2015 | Chief’s Choice Award, Radiation Medicine Program, Dept of Radiation Oncology, Faculty of Medicine, Princess Margaret Cancer Centre |
| 2014 | Alliance for Clinical Trials in Oncology Alliance Scholar Award, Alliance for Clinical Trials in Oncology Foundation |
| 2014 | Chief’s Choice for 2014/2015, Princess Margaret Cancer Centre |
| 2014 | Master of Health Science in Medical Radiation Sciences Best Guest Lecturer Award, Dept of Radiation Oncology, Faculty of Medicine, University of Toronto |
| 2013 | Outstanding Research Potential Award, University of Toronto |
| 2013 | Postgraduate Medical Education Excellence in Research Supervision Award, University of Toronto |
| 2013 | 2014 Alliance Scholar Award in Honor of Dr. Emil "Tom" Frei III |
| 2012 | Postgraduate Medical Education Excellence in Research Supervision Award, University of Toronto |
| 2010 | Scholarship, Government of Ontario |
| 2009 | Best Oral Presentation, The University of British Columbia |
| 2007 | Best Resident Poster Award, Canadian Association of Radiation Oncology |
| 2000 | Summer Research Award in Medicine, Medical Research Council of Canada |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Ger RB, Mohamed ASR, Awan MJ, Ding Y, Li K, Fave XJ, Beers AL, Driscoll B, Elhalawani H, Hormuth DA, Houdt PJV, He R, Zhou S, Mathieu KB, Li H, Coolens C, Chung C, Bankson JA, Huang W, Wang J, Sandulache VC, Lai SY, Howell RM, Stafford RJ, Yankeelov TE, Heide UAV, Frank SJ, Barboriak DP, Hazle JD, Court LE, Kalpathy-Cramer J, Fuller CD. A multi-institutional comparison of dynamic contrast-enhanced magnetic resonance imaging parameter calculations. Sci Rep 7(1):11185, 2017. e-Pub 2017. PMID: 28894197.
- Murray L, Longo J, Wan J, Chung C, Wang L, Dawson L, Milosevic M, Oza A, Brade A. Phase I dose escalation study of concurrent palliative radiation therapy with sorafenib in three anatomical cohorts (Thorax, Abdomen, Pelvis): The TAP study. Radiother Oncol 124(1):74-79, 2017. e-Pub 2017. PMID: 28668472.
- Doherty MK, Korpanty GJ, Tomasini P, Alizadeh M, Jao K, Labbé C, Mascaux CM, Martin P, Kamel-Reid S, Tsao MS, Pintilie M, Liu G, Bradbury PA, Feld R, Leighl NB, Chung C, Shepherd FA. Treatment options for patients with brain metastases from EGFR/ALK-driven lung cancer. Radiother Oncol 123(2):195-202, 2017. e-Pub 2017. PMID: 28363487.
- McNamara MG, Jiang H, Lim-Fat MJ, Sahebjam S, Kiehl TR, Karamchandani J, Coire C, Chung C, Millar BA, Laperriere N, Mason WP. Treatment Outcomes in 1p19q Co-deleted/Partially Deleted Gliomas. Can J Neurol Sci 44(3):288-294, 2017. PMID: 28488951.
- Kerbauy MN, Moraes FY, Lok BH, Ma J, Kerbauy LN, Spratt DE, Santos FP, Perini GF, Berlin A, Chung C, Hamerschlak N, Yahalom J. Challenges and Opportunities in Primary CNS Lymphoma: a systematic review. Radiother Oncol 122(3):352-361, 2017. e-Pub 2017. PMID: 28104300.
- Murray L, Menard C, Zadeh G, Au K, Bernstein M, Millar BA, Laperriere N, Chung C. Radiosurgery for brainstem metastases with and without whole brain radiotherapy: clinical series and literature review. J Radiat Oncol 6(1):1-10, 2017. e-Pub 2016. PMID: 28367275.
- Sandström H, Chung C, Jokura H, Torrens M, Jaffray D, Toma-Dasu I. Assessment of organs-at-risk contouring practices in radiosurgery institutions around the world - The first initiative of the OAR Standardization Working Group. Radiother Oncol 121(2):180-186, 2016. e-Pub 2016. PMID: 27816408.
- Li W, Cho YB, Ansell S, Laperriere N, Ménard C, Millar BA, Zadeh G, Kongkham P, Bernstein M, Jaffray DA, Chung C. The Use of Cone-Beam Computed Tomography for Image-Guided Gamma Knife Stereotactic Radiosurgery: Initial Clinical Evaluation. Int J Radiat Oncol Biol Phys 96(1):214-20, 2016. e-Pub 2016. PMID: 27511857.
- Brown PD, Jaeckle K, Ballman KV, Farace E, Cerhan JH, Anderson SK, Carrero XW, Barker FG, Deming R, Burri SH, Ménard C, Chung C, Stieber VW, Pollock BE, Galanis E, Buckner JC, Asher AL. Effect of Radiosurgery Alone vs Radiosurgery With Whole Brain Radiation Therapy on Cognitive Function in Patients With 1 to 3 Brain Metastases: A Randomized Clinical Trial. JAMA 316(4):401-409, 2016. PMID: 27458945.
- Wong KM, Ding K, Li S, Bradbury P, Tsao MS, Der SD, Shepherd FA, Chung C, Ng R, Seymour L, Leighl NB. A cost-Effectiveness Analysis of Using the JBR. 10-Based 15-Gene Expression Signature to Guide Adjuvant Chemotherapy in Early Stage Non-Small-Cell Lung Cancer. Clin Lung Cancer 2017 1:e41-e47, 2016. PMID: 27502323.
- Tudor JC, Davis EJ, Peixoto L, Wimmer ME, van Tilborg E, Park AJ, Poplawski SG, Chung C, Havekes R, Huang J, Gatti E, Pierre P, Abel T. Sleep deprivation impairs memory by attenuating mTORC1-dependent protein synthesis. Sci Signal 9(425):ra41, 2016. e-Pub 2016. PMID: 27117251.
- Li W, Bootsma G, Von Schultz O, Carlsson P, Laperriere N, Millar BA, Jaffray D, Chung C. Preliminary Evaluation of a Novel Thermoplastic Mask System with Intra-fraction Motion Monitoring for Future Use With Image-Guided Gamma Knife. Cureus 8(3):e531, 2016. e-Pub 2016. PMID: 27081592.
- Adilman R, Rajmohan Y, Brooks E, Urgoiti GR, Chung C, Hammad N, Trinkaus M, Naseem M, Simmons C, Adilman R, Rajmohan Y, Brooks E, Roldan Urgoiti G, Chung C, Hammad N, Trinkaus M, Naseem M, Simmons C. Social Media Use Among Physicians and Trainees: Results of a National Medical Oncology Physician Survey. J Oncol Pract 12(1):79-80, e52-60, 2016. e-Pub 2015. PMID: 26443837.
- Li W, Cho YB, Ansell S, Laperriere N, Menard C, Millar BA, Zadeh G, Kongkham P, Bernstein M, Jaffray D, Chung C. Image-Guidance for Gamma Knife Stereotactic Radiosurgery Using Cone-Beam Computed Tomography. Int J Radiat Oncol Biol Phys 96(1):214-220, 2016.
- Cho YB, Laperriere N, Hodaie M, Chung C. Hybrid isocenter technique for Gamma-Knife Perfexion treatment of trigeminal neuralgia. Med Dosim 41(4):271-276, 2016. PMID: 27839588.
- Hussein H, Chung C, Moshonov H, Miller N, Kulkarni SR, Scaranelo AM. Evaluation of Apparent Diffusion Coefficient to Predict Grade, Microinvasion, and Invasion in Ductal Carcinoma In Situ of the Breast. Acad Radiol 22(12):1483-8, 2015. e-Pub 2015. PMID: 26391856.
- Ellingson BM, Bendszus M, Boxerman J, Barboriak D, Erickson BJ, Smits M, Nelson SJ, Gerstner E, Alexander B, Goldmacher G, Wick W, Vogelbaum M, Weller M, Galanis E, Kalpathy-Cramer J, Shankar L, Jacobs P, Pope WB, Yang D, Chung C, Knopp MV, Cha S, van den Bent MJ, Chang S, Yung WK, Cloughesy TF, Wen PY, Gilbert MR, Jumpstarting Brain Tumor Drug Development Coalition Imaging Standardization Steering Committee. Consensus recommendations for a standardized Brain Tumor Imaging Protocol in clinical trials. Neuro Oncol 17(9):1188-98, 2015. e-Pub 2015. PMID: 26250565.
- Tieu MT, Lovblom LE, McNamara MG, Mason W, Laperriere N, Millar BA, Ménard C, Kiehl TR, Perkins BA, Chung C. Impact of glycemia on survival of glioblastoma patients treated with radiation and temozolomide. J Neurooncol 124(1):119-126, 2015. e-Pub 2015. PMID: 26015297.
- Armstrong TS, Ying Y, Wu J, Acquaye AA, Vera-Bolanos E, Gilbert MR, Brown PD, Vardy J, Chung C. The Relationship between Corticosteroids and Symptoms in Patients with Primary Brain Tumors-Utility of the Dexamethasone Symptom Questionnaire-Chronic. Neuro Oncol 14(8):1114-1120, 2015. e-Pub 2015. PMID: 25862766.
- Wazer DE, Hepel JT, Riker AI, Harness JK, Chung C, Khan AJ, Offersen BV, Poortmans P, Taghian A. In Regard to Vaidya et al. Int J Radiat Oncol Biol Phys 92(5):952-953, 2015. e-Pub 2015. PMID: 26194662.
- Chung C, Torrens M, Paddick I, Ryu S, Hanssens P, Jaffray D. Radiosurgery Nomenclature: A Confusion of Tongues. Int J Radiat Oncol Biol Phys 25(3):119-126, 2015. PMID: 26068485.
- Chung C, Metzer U, Menard C. Advances in MR and PET Imaging in Radiological Grading and Molecular Characterization of Glioma to Guide Treatment. Seminars in Radiation Oncology 25(3):167-171, 2015.
- Chung C, Metser U, Ménard C. Advances in Magnetic Resonance Imaging and Positron Emission Tomography Imaging for Grading and Molecular Characterization of Glioma. Semin Radiat Oncol 25(3):164-71, 2015. e-Pub 2015. PMID: 26050586.
- Sahgal A, Chan MW, Atenafu EG, Masson-Cote L, Bahl G, Yu E, Millar BA, Chung C, Catton C, O’Sullivan B, Irish JC, Gilbert R, Zadeh G, Cusimano M, Gentili F, Laperriere NJ. Image-guided intensity modulated radiation therapy (IG-IMRT) for skull base chordoma and chondrosarcoma: preliminary outcomes. Neuro Oncol 17(6):889-94, 2015.
- Lymberiou T, Galuszka S, Lee G, Xu W, Su S, Fyles A, Purdie T, Catton P, Chung C, Dinniwell R, Han K, Koch A, Levin W, Manchul L, Sappiatzer J, Mackenzie P, Liu FF. Predictors of Breast Radiotherapy Plan Modifications: Quality Assurance Rounds in a Large Cancer Centre. Radiother Oncol 114(1):17-21, 2015.
- Coolens C, Driscoll B, Chung C, Shek T, Gorjizadeh A, Ménard C, Jaffray D. Automated Voxel-Based Analysis of Volumetric Dynamic Contrast-Enhanced CT Data Improves Measurement of Serial Changes in Tumor Vascular Biomarkers. Int J Radiat Biol Phys 91(1):48-57, 2015. PMID: 25446606.
- Torrens M, Chung C, Chung HT, Hanssens P, Jaffray D, Kemeny A, Larson D, Levivier M, Lindquist C, Lippitz B, Novotny J, Paddick I, Prasad D, Yu CP. The standardization of terminology in stereotactic radiosurgery: report from the standardization committee of the International Leksell Gamma Knife®Society. J Neurosurg 121(Suppl):2-15, 2014. PMID: 25587587.
- Hahn E, Laperriere N, Millar BA, Oestreicher J, McGowan H, Krema H, De Angelis D, Hurwitz J, Simpson R, Tucker N, Chung C. Orbital Radiotherapy for Graves’ Ophthalmopathy: Measuring Clinical Efficacy and Impact. Pract Radiat Oncol 4(4):233-239, 2014.
- Jalali S, Chung C, Foltz W, Burrell K, Singh S, Hill R, Zadeh G. MRI biomarkers identify the differential response of glioblastoma multiforme to anti-angiogenic therapy. NeuroOncology 16(6):868-79, 2014. e-Pub 2014. PMID: 24759636.
- Mackenzie P, Fyles A, Wang W, Chung C. Advanced radiotherapy techniques for breast cancer to minimize cardiovascular risk. Breast Cancer Management 3(3):297-305, 2014. PMID: 21237584.
- McNamara MG, Lwin Z, Jiang H, Templeton AJ, Zadeh G, Bernstein M, Chung C, Millar BA, Laperriere N, Mason WP. Factors impacting survival following second surgery in patients with glioblastoma in the temozolomide treatment era, incorporating neutrophil/lymphocyte ratio and time to first progression. J Neurooncol 117(1):147-52, 2014.
- McNamara MG, Lwin Z, Jiang H, Chung C, Millar BA, Sahgal A, Laperriere N, Mason WP. Conditional probability of survival and post-progression survival in patients with glioblastoma in the temozolomide treatment era. J Neurooncol 117(1):153-60, 2014.
- Kurtz G, Zadeh G, Gingras-Hill G, Millar BA, Laperriere NJ, Bernstein M, Jiang H, Ménard C, Chung C. Salvage radiosurgery for brain metastases: prognostic factors to consider in patient selection. Int J Radiat Oncol Biol Phys 88(1):137-42, 2014.
- Tieu MT, Lovblom LE, MacNamara M, Mason W, Kiehl R, Rodin D, Laperriere N, Millar BA, Menard C, Perkins B, Chung C. Glycemia Impacts Survival of Glioblastoma Patients Treated with Radiation and Temozolomide. Journal of Neurooncology, 2014.
- Hahn E, Velazquez-Martin JP, Somani S, Payne D, Waldron J, Krema H, Simpson R, Laperriere N, Chung C. Palliative radiotherapy for choroidal metastases: Clinical outcomes and predictors of overall survival. Practical Radiation Oncology 4(4):233-9, 2014.
- Chung C, Mason. Salvage radiosurgery for high grade glioma in the era of modern systemic therapy. Can J Neurol Sci 40(6):761-2, 2013.
- Little A , Chung C, Perez-Ordonez B , Mikulis D , Valiante TA. High-grade intracranial chondrosarcoma presenting with haemorrhage. J Clin Neurosci 97(6):730-4, 2013.
- Krema H, Herrmann E, Albert-Green A, Payne D, Laperriere N, Chung C. Orthovoltage Radiotherapy in the Management of Medical Canthal Basal Cell Carcinoma. Br J Opthalmology 97(6):730-4, 2013.
- Chung C, Jalali S, Foltz W, Burrell K, Wildgoose P, Lindsay P, Graves C, Camphausen K, Milosevic M, Jaffray D, Zadeh G, Ménard C. Imaging Biomarker Dynamics in an Intracranial Murine Glioma Study of Radiation and Antiangiogenic Therapy. Int J Radiat Oncol Biol Phys 85(3):805-12, 2013. e-Pub 2012. PMID: 22929856.
- Ebinu JO, Lwu S, Monsalves E, Arayee M, Chung C, Laperriere NJ, Kulkarni AV, Goetz P, Zadeh G. Gamma Knife Radiosurgery for the Treatment of Cystic Cerebral Metastases. Int J Radiat Oncol Biol Phys 85(3):667-71, 2013. e-Pub 2012. PMID: 22885145.
- Lwu S, Goetz P, Monsalves E, Aryaee M, Ebinu J, Laperriere N, Menard C, Chung C, Millar BA, Kulkarni AV, Bernstein M, Zadeh G. Stereotactic radiosurgery for the treatment of melanoma and renal cell carcinoma brain metastases. Oncol Rep 29(2):407-12, 2013. e-Pub 2012. PMID: 23151681.
- Ruschin M, Komljenovic PT, Ansell S, Ménard C, Bootsma G, Cho YB, Chung C, Jaffray D. Cone Beam Computed Tomography Image Guidance System for a Dedicated Intracranial Radiosurgery Treatment Unit. Int J Radiat Oncol Biol Phys 85(1):243-250, 2013. e-Pub 2012. PMID: 22560556.
- Ruschin M, De Jean P, Ansell S, Bootsma G, Chung C, Ménard C, Cho YB, Jaffray DA. Initial performance characterization and clinical implementation of a novel image-guided system for Perfexion. J Neurosurg, 2013.
- Chung C, Tsao M, Lutz S. Conventional radiation therapy for brain metastases. J Radiat Oncol 1(3):211-219, 2012.
- Chung C. Impact of Internal Mammary Node Irradiation in High-Risk Patients. Oncology Exchange 10(4):4-5, 2011.
- Ibrahim GM, Chung C, Bernstein M. Competing for patients: an ethical framework for recruiting patient with brain tumors into clinical trials. J Neuro-oncol 104(3):623-7, 2011. PMID: 21318320.
- Chung C, Dawson L, Joshua A, Brade A. Radiation Recall Dermatitis Triggered by Multi Tyrosine Kinase Inhibitors: Sunitinib and Sorafenib. Anti-Cancer Drugs 21(2):209-209, 2010. PMID: 19952730.
- Chung C, Brade A. Radiosensitizers and anti-angiogenic agents for brain metastases. Journal of Pain Management 4(2):149-158, 2010.
- Chung C, Al Ali J, Owen D, Weiss A, Yoshida E, Tai I. Slivers of Liver in the Distal Duodenum: A Rare Cause of Gastrointestinal Bleeding from Metastatic Hepatocellular Carcinoma. Cases Journal 2(9344), 2009.
- Chung C, Stuart D, Keyes M. Radiation Recall Reaction Induced by Adjuvant Trastuzumab (Herceptin). Case Rep Med 2009(307894), 2009. PMID: 19746202.
- Berthelet E, Germain F, Chung C, Kumar D, Larsson S, Wong F, Kader H. Accelerated-simultaneous boost IMRT for locally advanced head and neck cancer: Analysis of outcomes and patterns of failure. Radiother Oncol 82:46-47, 2007.
- Chan V, Al Ali J, Owen D, Chung C, Yoshida E. A Mundane Situation Punctuated by Sudden Rash and Liver Failure: Unexpected, Unintended Clinical Consequences. Univ Toronto Med J 83:181-83, 2006.
- Maqbool T, Agarwal A, Sium A, Trang A, Chung C, Papadakos J. Informational and Supportive Care Needs of Brain Metastases Patients and Caregivers: a Systematic Review. J Cancer Educ. e-Pub 2016. PMID: 27041700.
- Kwan JYY, Croke J, Panzarella T, Ubhi K, Liu FF, Fyles A, Koch A, Dinniwell R, Levin W, McCready D, Chung C, Bender J. Supportive Care Needs and Perceptions of Alternative Follow-up Care Options Among Well Breast Cancer Patients: A Cross-sectional Survey. Journal of Cancer Survivorship.
- Mason M, Maurice C, McNamara MG, Tieu MT, Lwin Z, Millar BA, Menard C, Laperriere N, Milosevic M, Atenafu EG, Mason W, Chung C. Neutrophil-Lymphocyte Ratio Dynamics during Concurrent Chemo-radiotherapy for Glioblastoma is an Independent Predictor for Overall Survival. J Neurooncol. e-Pub 2017. PMID: 28332000.
- Wilke C, Zaid M, Chung C, Fuller CD, Mohamed ASR, Skinner H, Phan J, Gunn GB, Morrison WH, Garden AS, Frank SJ, Rosenthal DI, Chambers MS, Koay EJ,. Design and fabrication of a 3D-printed oral stent for head and neck radiotherapy from routine diagnostic imaging. 3D Printing in Medicine. e-Pub 2017. PMID: 29782600.
- Hahn E, Laperriere N, Krema H, Velazquez-Martin JP, Somani S, Waldron J, Simpson R, Payne D, Chung C. Clinical outcomes of hypofractionated radiation therapy for choroidal metastases: Symptom palliation, tumor control, and survival. Pract Radiat Oncol. e-Pub 2017. PMID: 28867543.
- Chung C, Ma H. Driving Toward Precision Medicine for Acute Leukemias: Are We There Yet?. Pharmacotherapy. e-Pub 2017. PMID: 28654205.
- Chung C, Menard C, Mason W, Foltz W, Coolens C, Driscoll B, Sinno N, Zadeh G, Bernstein M, Millar BA, Sahgal A, Camphausen K, Laperriere N, Brade A. Phase I Dose-Escalation Study of Sunitinib Concurrent with Radiosurgery in Patients with Brain Metastases. Radiotherapy and Oncology.
Invited Articles
- Jaffray DA, Chung C, Coolens C, Foltz W, Keller H, Menard C, Milosevic M, Publicover J, Yeung I. Quantitative imaging in radiation oncology: An emerging science and clinical service. Semin Radiat Oncol 25(4):292-304, 2015. e-Pub 2015. PMID: 26384277.
- Chung C, Laperriere N. How I treat glioblastoma. Clinical Practice 10(2):157-65, 2013.
- Ellingson BM, Chung C, Pope WB, Boxerman JL, Kaufmann TJ. Pseudoprogression, radionecrosis, inflammation or true tumor progression? Challenges associated with glioblastoma response assessment in an evolving therapeutic landscape. J Neurooncol 10:2375-2. e-Pub 2017. PMID: 28382534.
Other Articles
- Moraes FY, Chung C Radiation for Skull Base Meningiomas: Review of the Literature on the Approach to Radiotherapy. Chin Clin Oncol 6((Suppl 1):S3):S3, 2017. PMID: 28758407.
- Chung C New Hope for Brain Metastases. Connexions. RMP Newsletter 1, 2010.
- Ayala-Peacock DN, Attia A, Braunstein SE, Ahluwalia MS, Hepel J, Chung C, Contessa J, McTyre E, Peiffer AM, Lucas JT, Isom S, Pajewski NM, Kotecha R, Stavas MJ, Page BR, Kleinberg L, Shen C, Taylor RB, Onyeuku NE, Hyde AT, Gorovets D, Chao ST, Corso C, Ruiz J, Watabe K, Tatter SB, Zadeh G, Chiang VLS, Fiveash JB, Chan MD Prediction of New Brain Metastases after Radiosurgery: Validation and Analysis of Performance of a Multi-Institutional Nomogram. J Neurooncol. PMID: 28828698.
Editorials
- Johnson JM, Chung C. Glioblastoma: does PET shed light to a difficult problem?. Translational Cancer Research 5(S4), 2016.
- Wazer DE, Hepel JT, Riker AI, Harness JK, Chung C, Khan AJ, Offersen BV, Poortmans P, Taghian A. In Regard to Vadiya et al. International Journal of Radiation Oncology Biology Physics 92(5):952-953, 2015.
- Mackenzie P, Fyles A, Chung C. Radiotherapy for breast cancer, the TARGIT-A trial. Lancet 383(9930):1717, 2014.
- Ruschin M, Komljenovic PT, Ansell S, Ménard C, Bootsma G, Cho YB, Chung C, Jaffray D. In reply to Cheung. Int J Radiat Oncol Biol Phys 85(2):291-2, 2013. PMID: 23312270.
- Lee SL, Chung C. Experience of Attending the 2012 Annual ISMRM Scientific Conference. Ontario Medical Students Association Scrub-In Magazine, 2012.
Abstracts
- Hahn E, Velazquez-Martin JP, Somani S, Payne D, Waldron J, Krema H, Simpson R, Laperriere N, Chung C. Hypofractionated Palliative Radiation Therapy for Choroidal Metastases: Clinical Outcomes and Predictors of Overall Survival. International Journal of Radiation Oncology Biology Physics 96(2S):E510, 2016.
- Ghobadi K, Aleman D, Li W, Chung C, Jaffray D. Continuous Dose Delivery wih Gamma Knife Perfexion. Medical Physics 42(6):3576, 2015.
- Coolens C, Driscoll B, Foltz W, Chung C. Input function selection and T10 correction on DCE-MRI tumor response prediction using compared to volumetric DCE CT. Med Phys 42(6):3215, 2015. PMID: 26127196.
- Brown PD, Asher AL, Ballman KV, Farace E, Cerhan JH, Anderson SK, Carrero XW, Barker FG (II), Deming RL, Burris S, Menard C, Chung C, Stieber VW, Pollock BE, Galanis E, Buckner JC, Jaeckle KA.. NCCTG N0574 (Alliance): A Phase III Randomized Trial of Whole Brain Radiation Therapy (WBRT) in Addition to Radiosurgery (SRS) in Patients with 1 to 3 Brain Metastases. Journal of Clinical Oncology 33(15 (Supl)), 2015.
- Richard NM, Bernstein LJ, Mason WP, Laperriere N, Chung C, Millar BA, Maurice C, Edelstien K.. Rehabilitation of cognitive dysfunction in brain tumor patients. J Clin Oncol 33(15), 2015.
- Tieu MT, Lovblom LE, McNamara M, Mason W, Laperriere N, Millar BA, Menard C, Kiehl TR, Perkins BA, Chung C. Impact of Glycemia on Survival in Glioblastoma Patients. J Neurooncol, 2015.
- Lymberiou T, Galuszka S, Lee G, Xu W, Su S, Fyles A, Purdie T, Catton P, Chung C, Dinniwell R, Han K, Koch A. Levin W, Manchul L, Sappiatzer J, Mackenzie P, Liu FF. Predictors of breast radiotherapy plan modifications: Quality assurance rounds in a large cancer centre. Asia-Pacific Journal of Clinical Oncology 10:170, 2014.
- Khoja L, Kurtz G, Zadeh G, Laperriere N, Menard C, Millar BA, Kongkham P, Joshua A, Hogg D, Butler M, Chung C. Increased acute radiation effect (ARE) with ipilumumab and radiosurgery in patients with melanoma brain metastases. Neuro-Oncology 16(Suppl 5), 2014.
- McNamara M, Jiang H, Lim Fat M, Sahebjam S, Kiehl T, Karamchandani J, Coire C, Chung C, Miller BA, Laperriere N, Mason W.. Delaying radiotherapy in 1p19q co-deleted and partially deleted gliomas. Neuro-oncology 16(Suppl 5):v191, 2014.
- Mason M, McNamara M, Tieu M, Lwin Z, Millar BA, Menard C, Laperriere N, Milosevic M, Mason W, Chung C. Prognostic value of early changes in neutrophil and lymphocyte measures during chemoradiotherapy for glioblastoma. Neuro-Oncology 16:v191, 2014.
- Kurtz G, Zadeh G, Gingras-Hill G, MIllar BA, Laperriere N, Bernstein M, Menard C, Chung C. Salvage Radiosurgery for Brain Metastases: Prolonged Survival with Durable Tumor Control. Int J Radiat Oncol Biol Phys 84(3):S825, 2014.
- McNamara MG, Jiang H, Lim Fat MJ, Sahebjam S, Kiehl TR, Karamchandani J, Coire C, Chung C, Millar BA, Laperriere N, Mason W. Temozolomide for 1p19q co-deleted and partially deleted gliomas. Annals of Oncology 25(suppl_4), 2014.
- Mason MT, McNamara MG, Tieu MT, Lwin Z, Millar BA, Menard C, Laperriere N, Milosevic M, Mason WP, Chung C. Reduction in neutrophil-lymphocyte ratio during initial concurrent chemoradiotherapy is prognostic for survival of glioblastoma patients. Neuro-Oncology 16:ii23-ii24, 2014.
- Chung C, Li W, Bootsma G, von Schultz O, Cho YB, Carlsson P, Jaffray D. Clinical Evaluation of a Novel Thermoplastic Mask System with Intrafraction Motion Monitoring using IR Tracking and Cone-beam CT for Gamma Knife® Radiosurgery. Int J Radiat Oncol Biol Phys 90(1):s848, 2014.
- Li W, Cho YB, Hiemstra K, Jaffray DA, Chung C. Impact of Immobilization on Intra-Fraction Motion for Gamma Knife Stereotactic Radiosurgery Using Cone-Beam Computed Tomography. Int J Radiat Oncol Biol Phys 90(1 Suppl 1):S896, 2014.
- Lymberiou T, Galuszka S, Lee G, Xu W, Su S, Fyles A, Purdie T, Catton P, Chung C, Dinniwell R, Han K, Koch A, Levin W, Manchul L, Sappiatzer J, Mackenzie P, Liu F-F. Predictors of breast radiotherapy plan modifications: quality assurance rounds in a large cancer centre. Int J Radiat Oncol Biol Phys 90(S1):S254, 2014.
- Ayala-Peacock D, Attia A, Hepel J, Lucas J, Onyeuku N, Stavas M, Taylor R, Chung C, Fiveash J, Chan M. A Multi-institutional Predictive Nomogram for Distant Brain Failure in Patients Treated with Upfront Stereotactic Radiosurgery Without Whole Brain Radiation Therapy. Int J Radiat Oncol Biol Phys 90(1):S126, 2014.
- Adilman R, Rajmohan Y, Trinkaus M, Chung C, Naseem M, Hammad N, Leonard R, Urgoiti GR, Brooks E, Poonja Z, Simmons CE. Social media use amongst oncologists: Results of a national physician survey. Journal of Clinical Oncology 32(15 (Supl 1)), 2014.
- Edelstein K, Laperriere N, Bernstein L, Simpson R, Chung C, Millar MA, Mason WP. Neurocognitive functions in adults treated with radiation for primary brain tumors: A longitudinal study. J Clin Oncol 32(5s), 2014.
- Bender J, Singh Ubhi K, Alkazaz N, Catton P, Dinniwell R, Fyles A, Manchul L, Levin W, Liu FF, McCready D, Chung C. Low-risk Breast Cancer Patients’ Perceptions of Alternative Models of Survivorship Care. Radiotherap Oncol, 2013.
- Menjak IB, Maki E, Chung C, Berman HK, McCready DR, Sridhar SS. Discordance of ER and PR status between primary and recurrent breast cancer in association with endocrine therapy. Cancer Research 73(Suppl 24), 2013.
- Carlson R, Hiemstra K, Pearson S, Qiu X, Xu W, Fyles A, Chung C. Discovery and Validation of Simple Heart Measurements to Screen Patients Who Will Benefit from Deep Inspiration Breath Hold for Left Breast Irradiation. Cancer Research 73(24 supplement), 2013.
- Vera-Bolanos E, Acquaye AA, Brown PD, Chung C, Gilbert MR, Vardy J, Armstrong TS. Structure and reliability of the dexamethasone symptom questionnaire-chronic in primary or metastatic brain tumor patients. Neuro-Oncology 15(iii233), 2013.
- McNamara MG, Lwin Z, Jiang H, Chung C, Millar BA, Sahgal A, Laperriere N, Mason WP. Does time to first progression (TTP) impact post-progression survival in glioblastoma (GBM) in the temozolomide (TMZ) treatment era?. Neuro-Oncology 15(iii120), 2013.
- Jalali S, Chung C, Burrell K, Foltz W, Zadeh G. Non-invasive MRI biomarkers of response to anti-angiogenic therapy in glioblastoma multiforme. Neuro-Oncology 15(iii4), 2013.
- Menjak IB, Maki E, Berman HK, Chung C, McCready DR, Sridhar SS. Impact of endocrine therapy in early-stage breast cancer on time to locoregional recurrence. Journal of Clinical Oncology 31(26 Supl), 2013.
- Chung C, Driscoll B, Gorjizadeh A, Foltz W, Lee S, Menard C, Coolens C. Early Detection of Tumor Response using 4D DCE-CT and DCE-MRI in Patients Treated with Radiosurgery for Brain Metastases. Practical Radiation Oncology 3(2 Supl):S17-18, 2013.
- Stanescu T, Chung C, Menard C. Quantification of the magnetic susceptibility effects during MRI-guided radiosurgery of hemorrhagic brain metastases. Int J Radiat Oncol Biol Phys 84(3 Supl):S824-S825, 2012.
- Heydarian M, Wilson G, van Prooijen M, Cho YB, Tamerou M, Chung C, Laperriere N, Jaffray D. Invasive Eye Fixation and Monitoring System for the Treatment of Choroidal Melanoma (CM) Using the Gamma Knife Perfexion (GK). Int J Radiat Oncol Biol Phys 84(3 Supl):S285, 2012.
- Chung C, Menard C, Stevens C, Laperriere N, Millar BA, Bernstein M, Zadeh G, Mason W, Brade A. Phase I Dose Escalation Study of Sunitinib and Radiosurgery for Brain Metastases. Int J Radiat Oncol Biol Phys 84(3 Supl):S77, 2012.
- Chung C, Menard C, Stevens C, Laperriere N, Millar BA, Bernstein M, Zadeh G, Mason W, Brade A. Phase I Dose Escalation Study of Sunitinib and Radiosurgery for Brain Metastases. Radiotherapy and Oncology 104:S71, 2012.
- Lee SL, Foltz W, Driscoll B, Fatemi A, Ménard C, Coolens C, Chung C. Comparison of Arterial Input Functions by Magnitude and Phase Signal Measurement in Dynamic Contrast Enhancement MRI using a Dynamic Flow Phantom. Magn Reson Med, 2012.
- Herrmann E, Krema, Chung C. Radiotherapy for treatment of basal cell carcinoma of the medial canthal region. Radiotherapy and Oncology 103:S478, 2012.
- Jalali S, Foltz W, Burrell K, Chung C, Zadeh G. Identification of MRI biomarkers and histopathological alterations in response to combination therapy with antiangiogenic agents and radiation in a murine model of glioma tumor, Part B, Skull Base. Journal of Neurological Surgery, 2012.
- Ruschin M, De Jean P, Ansell S, Bootsma G, Chung C, Ménard C, Cho YB, Jaffray D. Initial performance characterization and clinical implementation of a novel image-guided system for Perfexion. J Neurosurg, 2012.
- Chung C, Millar BA, Menard C, Zadeh G, Bernstein M, Laperriere N. Radiosurgery for Brainstem Metastases. J Neurosurg, 2012.
- Jalali S, Foltz W, Burrell K, Lee JI, Agnihorti S, Menard C, Chung C, Zadeh G. Identification of MRI biomarkers and histopathological alterations in response to combinatorial therapy with sunitinib and radiation in a murine model of glioma. Neuro-Oncology 13:iii6-iii7, 2011.
- Li W, Ruschin M, Tamerou M, Cho YB, Chung C, Ménard C, Jaffray D. Evaluating setup reproducibility between a CT planning and gamma knife radiosurgery couch using a relocatable head frame. Int J Radiat Oncol Biol Phys 81(2):S87, 2011.
- Ruschin ME, Komlijenovic PT, Cho Y, Chung C, Menard C, Jaffray D. A novel prototype for image-guidance on a dedicated radiosurgery treatment unit. Int J Radiat Oncol Biol Phys 81(2):S60, 2011.
- Brade AM, Kim SW, Chung C, Wan JF, Southwood B, Chaudary N, Wang L, Milosevic M, Oza AM. Final results: A phase I study of sorafenib and palliative radiation in patients with malignancy in the thorax, abdomen or pelvis. Journal of Clinical Oncology 29(15 Suppl), 2011.
- Chung C, Foltz W, Lindsay P, Burrell K, Kallehauge J, Wildgoose P, Camphausen K, Jaffray D, Zadeh G, Menard C. Intracranial murine tumor investigation of radiation and antiangiogenic agents using serial MRI 78(3 Suppl):S663, 2010.
- Chung C, Foltz W, Wildgoose P, Burrell K, Lindsay P, Kallehauge J, Camphausen K, Kassner A, Jaffray DA, Menard C, Zadeh G. Biomarker evaluation during an image-guided intracranial murine glioma study of radiation and sunitinib. Cancer Res 70(8 Suppl), 2010.
- Chung C, Foltz W, Lindsay P, Burrell K, Kallehauge J, Wildgoose P, Camphausen K, Jaffray D, Zadeh G, Menard C. Intracranial murine tumor investigation of radiation and antiangiogenic agents using serial MRI. International Journal of Radiation Oncology Biology Physics 78(3 Suppl 1):S663, 2010.
- Berthelet E, Germain F, Chung C, Kumar D, Larsson S, Wong F, Kader H. Accelerated-simultaneous boost imrt for locally advanced head and neck cancer: Analysis of outcomes and patterns of failure 82(S1):S46-S47, 2007.
- Chung C, Knight B, Peters C, Malloff C, Lam W, Sheehan F. Detection of circulating tumour cells from peripheral blood samples by a novel cell concentration method and immunohistochemistry (IHC) compared with reverse transcriptase-polymerase chain reaction (RT-PCR) in Stage III/IV Non-small cell lung cancer (NSCLC). ). J Thorac Oncol 2(8):S408, 2007.
- Chung C, Weir L, Bergman A, Kwa W, Welsh M, Fong M, Popescu IA. Improved dose calculation with Monte Carlo for internal mammary nodal irradiation for breast cancer. Radiother Oncol 81(Suppl 1):S1, S1-533, 2006.
- Berthelet E, Truong P, Chung C, Moravan V, Wong F, Kwan W, Currie T, Patterson K, Olivotto I. Preliminary Validation of the RTOG Acute Skin Toxicity Scoring System in Patients Undergoing Adjuvant Radiotherapy for Breast Cancer. Radiother Oncol 76(S1), 2005.
- Chung C, Keyes M, Kwa W, Weir L, Parsons C. Adjuvant Axillary Radiotherapy for Breast Cancer: Is CT Planning with Nodal Contouring Better Than Traditional Planning?. Radiother Oncol 76(1):S10, 2005.
- Berthelet E, Truong P, Chung C, Moravan V, Wong F, Kwan W, Curne T, Patterson K, Olivotto I. Preliminary Validation of the RTOG Acute Skin Toxicity Scoring System in Patients Undergoing Adjuvant Radiotherapy for Breast Cancer. Radiother Oncol 76(1):S12, 2005.
- Chung C, Berthelet E, Truong P, Wong F, Currie T, Kwan W, Patterson K. The Effect of Vitamin E Cream on Acute Skin Toxicity During Adjuvant Radiotherapy for Breast Cancer. Radiother Oncol 73(S1), 2005.
- Chung C, Keyes, Kwa W, Weir L, Parsons C. Adjuvant Axillary Radiotherapy for Breast Cancer: Is CT Planning with Nodal Contouring Better Than Traditional Planning?. Radiother Oncol 76(S1), 2005.
- Johnson JM, Jen ML, Shin DD, Hou P, Chung C, Schomer DF, Liu HL. Effect of Lesion-related Signal Variation in Proton Density Reference Image on Blood Flow Quantification with Arterial Spin Labeling MRI for Differentiating Pseudoprogression from True Progression in Gliomas.
Book Chapters
- Mawrin C, Chung C, Preusser M. Biology and clinical management challenges in meningioma. In: In: Am Soc Clin Oncol Educ Book. 35, 106-15, 2015.
- Chung C. Imaging biomarkers in preclinical studies on brain tumours'. In: Biomarkers in Disease: Methods, Discovers and Applications -- Biomarkers in Cancer. Springer, 2014.
- Chung C, Nam D, Stupp R. CNS Tumors. In: Union for International Cancer Control (UICC) Manual of Clinical Oncology, 2014.
- Chung C, Chang E. Primary Tumors of the Central Nervous System. In: Radiation Oncology in Palliative Cancer Care. 1. John Wiley & Sons, Ltd, 2013.
- Chung C, Laperriere N. Management of Intracranial Metastases. In: Principles and Practice of Palliative Care and Supportive Oncology. 4. Philadelphia: Lippincott Williams & Wilkins, 2012.
- Chung C, Brade A. Radiosensitizers and Anti-angiogenic agents for brain metastases. In: Bone and Brain Metastases: Advances in research and treatment. New York: Nova Science Publishers, Inc, 2010.
Grant & Contract Support
| Title: | Clinical Investigation of Frameless, Adaptive, Image-guided Gamma Knife Radiosurgery |
| Funding Source: | Canadian Institutes of Health Research |
| Role: | Principal Investigator |
| Title: | A phase II study of PX-866 in patients with glioblastoma multiforme at time of first relapse or progression |
| Funding Source: | National Cancer Institute of Canada (NCIC) |
| Role: | Collaborator |
| Title: | Discovery of biomarkers to guide individualized therapy in patients with brain metastasis receiving radiotherapy |
| Funding Source: | Brain Tumor Foundation of Canada |
| Role: | Principal Investigator |
| Title: | Anti-VEGF therapy in murine brain radionecrosis model |
| Funding Source: | Canadian Association of Radiation Oncologists (CARO) |
| Role: | Principal Investigator |
| Title: | Imaging tumour hypoxia: feasibility of EF5-PET in prostate cancer |
| Funding Source: | Canadian Association of Radiation Oncologists (CARO) |
| Role: | Co-Principal Investigator |
| Title: | Introducing Sunitinib with Radiotherapy and Temozolamide in an Xenograft Glioblastoma Model |
| Funding Source: | Canadian Association of Radiation Oncologists (CARO) |
| Role: | Co-Principal Investigator |
| Title: | A randomized phase III study of temozolomide and short-course radiation versus short-course radiation alone in the treatment of newly diagnosed glioblastoma multiforme in elderly patients |
| Funding Source: | National Cancer Institute of Canada (NCIC) |
| Role: | Principal Investigator |
| Title: | Validating the accuracy of a relocatable frame for PERFEXIONTM based stereotactic radiotherapy |
| Funding Source: | PMH – Elekta |
| Role: | Collaborator |
| Title: | ACTION Research Grant for Neuropathic Pain Research |
| Funding Source: | ACTION |
| Role: | Principal Investigator |
| Title: | Primary chemotherapy with temozolomide vs. radiotherapy in patients with low-grade gliomas after stratification for genetic 1P loss: a phase III study |
| Funding Source: | National Cancer Institute of Canada (NCIC) |
| Role: | Collaborator |
| Title: | A randomized, double blind, placebo controlled, multicenter phase III trial of bevacizumab, temozolomide and radiotherapy, followed by bevacizumab and temozolomide versus placebo, temozolomide and radiotherapy followed by placebo and temozolomide in patients with newly diagnosed glioblastoma |
| Funding Source: | F. Hoffmann-la Roche Ltd. (Basel, Switzerland) |
| Role: | Collaborator |
| Title: | Imaging & Serum Biomarkers for Detection of Cardiac Injury from Radiotherapy |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Novel Intervention to Reduce Patient and Caregiver Anxiety around Radiation Treatment for Brain Tumors with a Customized Neuro-Imaging Referenced Symptom Video |
| Funding Source: | The Department of Psychiatry Hackett Family Foundation Development Award |
| Role: | Principal Investigator |
| Title: | A Multidisciplinary Approach to Improve Understanding, Treatments and Outcomes for Cancer Patients with Brain Metastases |
| Funding Source: | The University of Texas MD Anderson Cancer Center Multidisciplinary Research Program |
| Role: | Co-Investigator |
| Title: | Biomarker Correlative Study, Alliance for Clinical Trials in Oncology Phase II Study: Corticosteroids + Bevacizumab vs. Corticosteroids + Placebo for Radionecrosis after Radiosurgery for Brain Metastases |
| Funding Source: | Alliance for Clinical Trials in Oncology Foundation |
| Role: | Principal Investigator |
| Title: | Serial Advanced Magnetic Resonance Imaging (MRI) for Guidance of Personalized Adaptive Radiotherapy for High Grade Glioma |
| Funding Source: | Dr. Marnie Rose Foundation |
| Role: | Principal Investigator |
| Title: | Development of a Biologically Targeted, Adaptive Radiotherapy Approach for GBM |
| Funding Source: | Internal Research Grant, MDACC |
| Role: | Principal Investigator |
| Title: | Comprehensive evaluation of tumor oxygenation, metabolism and blood supply of high grade glioma using Dynamic FAZA PET-MR |
| Funding Source: | MDACC Radiation Oncology Department Seed Grant |
| Role: | Principal Investigator |