Chelain R Goodman, MD, PhD
Department of Radiation Oncology, Division of Radiation Oncology
About Dr. Chelain R Goodman
Chelain R. Goodman, M.D., Ph.D., is an Assistant Professor in the Division of Radiation Oncology at the University of Texas MD Anderson Cancer Center where she specializes in the treatment of early stage and locally advanced breast cancer using radiotherapy. Dr. Goodman attended Swarthmore College for her undergraduate training and was awarded her medical degree (MD) and PhD in Molecular Pharmacology and Structural Biology at Thomas Jefferson University. Her doctoral dissertation focused on mechanisms underlying therapeutic resistance in the treatment of breast cancer. She completed her clinical radiation oncology residency at Northwestern University Feinberg School of Medicine, where she served as chief resident from 2019-2020. Dr. Goodman’s research interests focus on the identification and validation of novel tumor- and patient-derived biomarkers to tailor radiotherapy treatment decisions and techniques. She is a Breast Cancer Research Foundation (BCRF) Investigator and is the current awardee of the American Society for Radiation Oncology (ASTRO)-BCRF Career Development Award to End Breast Cancer. Dr. Goodman recently was awarded the NIH/NCI K12 Institutional Career Development Award to support her research endeavors. The ultimate goal of Dr. Goodman’s research program is to improve quality of care by moving towards more personalized “precision” radiotherapy for the treatment of breast cancer.
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2015 | Jefferson College of Biomedical Sciences, Thomas Jefferson University, Philadelphia, PA, USA, PHD, Molecular Pharmacology and Structural Biology |
| 2015 | Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA, MD, Doctor of Medicine |
| 2005 | Swarthmore College, Swarthmore, PA, USA, BA, Biology, Psychology |
Postgraduate Training
| 2016-2020 | Clinical Residency, Radiation Oncology, McGaw Medical Center of Northwestern University Feinberg School of Medicine, Chicago, IL |
| 2015-2016 | Clinical Internship, Internal Medicine, Lankenau Medical Center, Wynnewood, PA |
Board Certifications
| 2022 | American Board of Radiology (ABR), Radiation Oncology |
Experience & Service
Academic Appointments
Adjunct Assistant Professor, Department of Radiation Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2021 - 2022
Institutional Committee Activities
Chair, Patient Education Committee, Department of Breast Radiation Oncology, 2022 - Present
Member, Breast Radiation Oncology Treatment Guidelines Committee, 2022 - Present
Faculty Senate Representative, Division of Radiation Oncology, UT MD Anderson Cancer Center Faculty Senate, 2022 - Present
Chair, Breast Treatment Planning Directives Committee, 2022 - Present
Member, Radiation Oncology Strategic Initiatives (ROSI) Health Services Award Review Committee, Division of Radiation Oncology, 2021 - 2021
Member, Grand Rounds Planning Committee, Division of Radiation Oncology, 2021 - Present
Honors & Awards
| 2022 | NIH/NCI K12 Clinician Scientist Institutional Career Development Award |
| 2022 | MDACC Institutional Research Grant, MDACC |
| 2021 | BCRF Investigator, Breast Cancer Research Foundation (BCRF) |
| 2021 | ASTRO-BCRF Career Development Award to End Breast Cancer Grant Awardee, American Society for Radiation Oncology and Breast Cancer Research Foundation (ASTRO-BCRF) |
| 2020 | Susan Perlman Award, Finalist, McGaw Medical Center of Northwestern University Feinberg School of Medicine |
| 2019 | Chief Resident, Department of Radiation Oncology, Northwestern University Feinberg School of Medicine |
| 2019 | Roentgen Resident Research Award, Radiological Society of North America (RSNA) |
| 2018 | Brinson Foundation Medical Research Junior Investigator, The Brinson Foundation |
| 2018 | Friends of Prentice Research Grant Awardee, The Friends of Prentice Grant Initiative |
| 2018 | 2018 Publication Award, Honorary Mention, Radiation Oncology Institute (ROI) |
| 2018 | Lasky Foundation Breast Cancer Resident Research Award, Chicago Radiological Society (CRS) |
| 2017 | Best of ASTRO Oral Presentation, American Society for Radiation Oncology (ASTRO) |
| 2017 | Conquer Cancer Foundation Merit Award, American Society of Clinical Oncology (ASCO) |
| 2017 | Society for Translational Oncology, Fellow, Society for Translational Oncology Fellows’ Forum (STOFF) |
| 2017 | Lynn Sage Symposium Scholar Award, 19th Annual Lynn Sage Breast Cancer Symposium |
| 2013 | Best Poster Presentation Award, MD/PhD Category, Sigma Xi Student Research Day, Jefferson College of Biomedical Sciences, Thomas Jefferson University |
| 2012 | Alumni Association Graduate Student Travel Fellowship Award, Jefferson College of Biomedical Sciences, Thomas Jefferson University |
| 2011 | Rieders Renaissance Foundation Graduate Student Recognition Award, Jefferson College of Biomedical Sciences, Thomas Jefferson University |
| 2009 | Hobart Amory Hare Honor Society Award, Sidney Kimmel Medical College, Thomas Jefferson University |
| 2007 | Dubbs MD/PhD Fellowship, Sidney Kimmel Medical College, Thomas Jefferson University |
| 2007 | Benjamin & Mary Siddons Measey MD/PhD Fellowship, Sidney Kimmel Medical College, Thomas Jefferson University |
| 2004 | Howard Hughes Medical Institute Undergraduate Research Fellowship, Swarthmore College |
| 2003 | Jean and Alden Todd Scholar, Swarthmore College |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Goodman CR, Strauss JB. One Way or Another: An Oligorecurrence After An Oligometastasis of an Estrogen Receptor-Positive Breast Cancer. Int J Radiat Oncol Biol Phys 114(4):571-572, 2022. e-Pub 2022. PMID: 36244388.
- Bralet MC, Mitelman SA, Goodman CR, Lincoln S, Hazlett EA, Buchsbaum MS. Fluorodeoxyglucose positron emission tomography scans in patients with alcohol use disorder. Alcohol Clin Exp Res 46(6):994-1010, 2022. e-Pub 2022. PMID: 35451074.
- Dover LL, Hentz C, Kahn JM, Lee A, Masters A, Doke K, Goodman CR. Implications of medical board certification practices on family planning and career trajectory for early career female radiation oncologists. Pract Radiat Oncol 12(2):95-102, 2022. e-Pub 2021. PMID: 35000892.
- Corrigan K, Lei X, Ahmad N, Arzu I, Bloom E, Goodman CR, Hoffman KE, Joyner M, Mayo L, Mitchell M, Nead KT, Perkins GH, Reed V, Reddy JP, Schlembach P, Shaitelman SF, Stauder MC, Strom EA, Tereffe W, Woodward WA, Smith BD. Adoption of Ultrahypofractionated Radiation Therapy in Breast Cancer Patients. Advances in Radiation Oncology 7(2):100877, 2022.
- Rogacki K, Gutiontov S, Goodman CR, Jeans EB, Hasan Y, Golden DW. Analysis of the radiation oncology in-training examination content using a clinical care path conceptual framework. Applied Radiation Oncology 10(3):41-51, 2021.
- Marsiglio JA, Rosenberg DM, Rooney MK, Goodman CR, Gillespie EF, Hirsch AE, Holliday EB, Kimple RJ, Thomas CR, Golden DW. Mentorship Initiatives in Radiation Oncology: A Scoping Review of the Literature. Int J Radiat Oncol Biol Phys 110(2):292-302, 2021. e-Pub 2021. PMID: 33412265.
- Goodman CR, Sim AJ, Jeans EB, Anderson JD, Dooley S, Agarwal A, Tye K, Albert A, Gillespie EF, Tendulkar RD, Fuller CD, Kavanagh BD, Campbell SR. No Longer a Match: Trends in Radiation Oncology National Resident Matching Program (NRMP) Data from 2010-2020 and Comparison Across Specialties. Int J Radiat Oncol Biol Phys 110(2):278-287, 2021. e-Pub 2021. PMID: 33716120.
- Bates JE, Parekh A, Goodman CR, Chowdhary M, Culbert MM, Royce TJ, Amdur RJ. The Geography of Employment Outcomes for Radiation Oncology Graduates in 2019. Int J Radiat Oncol Biol Phys 109(4):1119-1123, 2021. e-Pub 2020. PMID: 33239210.
- Dooley S, Sim AJ, Campbell SR, Jeans EB, Anderson JD, Tye K, Goodman CR*. In Reply to Taunk et al. Int J Radiat Oncol Biol Phys 109(3):835-836, 2021. PMID: 33516445.
- Campbell SR, Jeans EB, Albert A, Agarwal A, Tye K, Goodman CR*. Radiation Oncology Initial Certification Qualification Examinations: The Resident Experience in 2019. Pract Radiat Oncol 11(1):5-12, 2021. e-Pub 2020. PMID: 32428765.
- Agarwal A, Royce TJ, Goodman CR, Chowdhary M. Unfilled Positions in the 2019 National Resident Matching Program Radiation Oncology Match and Supplemental Offer and Acceptance Program. Pract Radiat Oncol 9(6):501-502, 2019. PMID: 31685167.
- Rice SR, Saboury B, Houshmand S, Salavati A, Kalbasi A, Goodman CR, Werner TJ, Vujaskovic Z, Simone CB, Alavi A. Quantification of global lung inflammation using volumetric 18F-FDG PET/CT parameters in locally advanced non-small-cell lung cancer patients treated with concurrent chemoradiotherapy: a comparison of photon and proton radiation therapy. Nucl Med Commun 40(6):618-625, 2019. PMID: 31095527.
- Goodman CR, Hatoum S, Seagle BL, Donnelly ED, Barber EL, Shahabi S, Matei DE, Strauss JB. Association of chemotherapy and radiotherapy sequence with overall survival in locoregionally advanced endometrial cancer. Gynecol Oncol 153(1):41-48, 2019. e-Pub 2019. PMID: 30660345.
- Albert AA, Knoll MA, Doke K, Masters A, Lee A, Dover L, Hentz C, Puckett L, Goodman CR, Osborn VW, Barry P, Jagsi R. #WomenWhoCurie: Leveraging Social Media to Promote Women in Radiation Oncology. Adv Radiat Oncol 4(2):218-225, 2019. e-Pub 2019. PMID: 31011664.
- Goodman CR, Strauss JB. Circulating Tumor Cells and Radiotherapy Benefit in Early Breast Cancer-Reply. JAMA Oncol 5(1):112, 2019. PMID: 30476949.
- Goodman CR, Seagle BL, Friedl TWP, Rack B, Lato K, Fink V, Cristofanilli M, Donnelly ED, Janni W, Shahabi S, Strauss JB. Association of Circulating Tumor Cell Status With Benefit of Radiotherapy and Survival in Early-Stage Breast Cancer. JAMA Oncol 4(8):e180163, 2018. e-Pub 2018. PMID: 29800954.
- Goodman CR, Seagle BL, Kocherginsky M, Donnelly ED, Shahabi S, Strauss JB. 21-Gene Recurrence Score Assay Predicts Benefit of Post-Mastectomy Radiotherapy in T1-2 N1 Breast Cancer. Clin Cancer Res 24(16):3878-3887, 2018. e-Pub 2018. PMID: 29685878.
- Sachdev S, Goodman CR, Neuschler E, Kalakota K, Cutright D, Donnelly ED, Hayes JP, Prescott AE, Mirabelli G, Strauss JB. Radiotherapy of MRI-detected involved internal mammary lymph nodes in breast cancer. Radiat Oncol 12(1):199, 2017. e-Pub 2017. PMID: 29258542.
- Seagle BL, Shilpi A, Buchanan S, Goodman C, Shahabi S. Low-grade and high-grade endometrial stromal sarcoma: A National Cancer Database study. Gynecol Oncol 146(2):254-262, 2017. e-Pub 2017. PMID: 28596015.
- Goodman CR, DeNittis A. Photon irradiation using a water bath technique for treatment of confluent carcinoma in situ of the hand, digits, and nail bed: a case report. J Med Case Rep 11(1):86, 2017. e-Pub 2017. PMID: 28356127.
- Goodman CR, Sato T, Peck AR, Girondo MA, Yang N, Liu C, Yanac AF, Kovatich AJ, Hooke JA, Shriver CD, Mitchell EP, Hyslop T, Rui H. Steroid induction of therapy-resistant cytokeratin-5-positive cells in estrogen receptor-positive breast cancer through a BCL6-dependent mechanism. Oncogene 35(11):1373-85, 2016. e-Pub 2015. PMID: 26096934.
- Sato T, Tran TH, Peck AR, Girondo MA, Liu C, Goodman CR, Neilson LM, Freydin B, Chervoneva I, Hyslop T, Kovatich AJ, Hooke JA, Shriver CD, Fuchs SY, Rui H. Prolactin suppresses a progestin-induced CK5-positive cell population in luminal breast cancer through inhibition of progestin-driven BCL6 expression. Oncogene 33(17):2215-24, 2014. e-Pub 2013. PMID: 23708665.
- Most P, Lerchenmüller C, Rengo G, Mahlmann A, Ritterhoff J, Rohde D, Goodman C, Busch CJ, Laube F, Heissenberg J, Pleger ST, Weiss N, Katus HA, Koch WJ, Peppel K. S100A1 deficiency impairs postischemic angiogenesis via compromised proangiogenic endothelial cell function and nitric oxide synthase regulation. Circ Res 112(1):66-78, 2013. e-Pub 2012. PMID: 23048072.
- Schneiderman JS, Hazlett EA, Chu KW, Zhang J, Goodman CR, Newmark RE, Torosjan Y, Canfield EL, Entis J, Mitropoulou V, Tang CY, Friedman J, Buchsbaum MS. Brodmann area analysis of white matter anisotropy and age in schizophrenia. Schizophr Res 130(1-3):57-67, 2011. e-Pub 2011. PMID: 21600737.
- Völkers M, Rohde D, Goodman C, Most P. S100A1: a regulator of striated muscle sarcoplasmic reticulum Ca2+ handling, sarcomeric, and mitochondrial function. J Biomed Biotechnol 2010:178614, 2010. e-Pub 2010. PMID: 20368797.
- Buchsbaum MS, Haznedar M, Newmark RE, Chu KW, Dusi N, Entis JJ, Goldstein KE, Goodman CR, Gupta A, Hazlett E, Iannuzzi J, Torosjan Y, Zhang J, Wolkin A. FDG-PET and MRI imaging of the effects of sertindole and haloperidol in the prefrontal lobe in schizophrenia. Schizophr Res 114(1-3):161-71, 2009. e-Pub 2009. PMID: 19695836.
- Hollander E, Buchsbaum MS, Haznedar MM, Berenguer J, Berlin HA, Chaplin W, Goodman CR, LiCalzi EM, Newmark R, Pallanti S. FDG-PET study in pathological gamblers. 1. Lithium increases orbitofrontal, dorsolateral and cingulate metabolism. Neuropsychobiology 58(1):37-47, 2008. e-Pub 2008. PMID: 18781089.
- Garakani A, Buchsbaum MS, Newmark RE, Goodman C, Aaronson CJ, Martinez JM, Torosjan Y, Chu KW, Gorman JM. The effect of doxapram on brain imaging in patients with panic disorder. Eur Neuropsychopharmacol 17(10):672-86, 2007. e-Pub 2007. PMID: 17560768.
Invited Articles
- Goodman CR, Speers CW. The Role of Circulating Tumor Cells in Breast Cancer and Implications for Radiation Treatment Decisions. Int J Radiat Oncol Biol Phys 109(1):44-59, 2021. e-Pub 2020. PMID: 32882354.
Manuals, Teaching Aids, Other Teaching Publications
- Inflammatory Breast Cancer clinical providers at the University of Texas MD Anderson Cancer Center. Breast Cancer - Inflammatory (IBC). The University of Texas MD Anderson Cancer Center: Houston, TX.
Other Articles
- Goodman CR, Campbell SR Radiation Oncology Graduate Medical Education in the Time of COVID-19. ASTRO News Summer 2020, 2020.
- Dover L, Goodman CR Advocacy Day 2019: Two residents share their experiences and why they attend this annual event. ASTRO News Advocacy Day 2019, 2019.
- Goodman CR, Marcrom S An Open Letter to the American Board of Radiology Regarding the 2018 Qualifying Examinations for Radiation Oncology, 2018.
- Goodman CR Induction of a therapy-resistant cytokeratin 5-positive cell population by 3-ketosteroids in luminal breast cancer. ETD Collection for Thomas Jefferson University, 2013.
Editorials
- Dooley S, Sim AJ, Campbell SR, Jeans EB, Anderson JD, Tye K, Goodman CR. Opportunities to Improve Radiation Oncology Medical Education in the Post-Pandemic Era. Int J Radiat Oncol Biol Phys 108(2):455-457, 2020. PMID: 32890531.
- Goodman CR, Campbell SR, Jeans EB, Agarwal A, Tye K, Kahn JM. Modernization of Board Certification in Radiation Oncology: Opportunities Following COVID-19. Int J Radiat Oncol Biol Phys 108(2):458-461, 2020. PMID: 32890532.
- Kahn J, Goodman CR, Albert A, Agarwal A, Jeans E, Tye K, Campbell SR, Marcrom S, Colbert LE. Top Concerns of Radiation Oncology Trainees in 2019: Job Market, Board Examinations, and Residency Expansion. Int J Radiat Oncol Biol Phys 106(1):19-25, 2020. PMID: 31648872.
Abstracts
- Shaitelman SF, Gandhi A, Xu T, DeSnyder S, Smith GL, Lin R, Barcenas C, Stauder MC, Hoffman KE, Strom EA, Ferguson S, Smith BD, Woodward WA, Perkins GH, Mitchell MP, Goodman CR, Aldrich M, Travis M, Lilly S, Bedrosian I. Prospective, Longitudinal Assessment of Lymphedema-related Quality of Life for Locally Advanced Breast Cancer Patients: A Foundation for Needed Elements in a Lymphedema Screening Program. American Radium Society 2022 Annual Meeting, 2022.
- Seol SW, Pflederer T, Weller L, Goodman CR, Donnelly ED, Strauss JB.. A comparison of outcomes in early breast cancer after external beam radiotherapy, intraoperative radiotherapy, or observation: A retrospective cohort study across a large health system. International Journal of Radiation Oncology Biology Physics 111(S3):e2111-e212, 2021.
- Seol SW, Pflederer T, Weller L, Goodman C, Donnelly E, Hayes J, Strauss J. Irradiation With or Without Boost in Low Risk Early Breast Cancer: Data from a Large Health System. European Society for Radiation Oncology (ESTRO), 2021.
- Bajaj A, Petras K, Goodman CR, Elmasri A, Donnelly EDD, Hayes JP, Phillip R, Wozniak M, Strauss JB.. The impact of cardiac sparing techniques on heart and lung dose in the setting of partial breast irradiation: a dosimetric follow-up to the IMPORT Low Trial. International Journal of Radiation Oncology Biology Physics 108(3S):e31, 2020.
- Seol SW, Pflederer T, Goodman CR, Donnelly ED, Prescott A, Weller L, Strauss JB.. Outcomes of breast brachytherapy in Stage I breast cancer – data from a large health system. International Journal of Radiation Oncology Biology Physics 108(3S):e42, 2020.
- Rogacki K, Goodman CR, Gutiontov S, Jeans E, Hasan Y, Strauss JB, Golden DW. Analysis of Question Content of the American College of Radiology Radiation Oncology In-Training Examination Years 2016-2019. International Journal of Radiation Oncology Biology Physics 108(3S):e439, 2020.
- Rogacki K, Goodman CR, Gutiontov S, Jeans E, Hasan Y, Strauss JB, Golden, DW. Analysis of Question Content of the American College of Radiology Radiation Oncology In-Training Examination Years 2016-2019. International Journal of Radiation Oncology Biology Physics 108(3S):e42, 2020.
- Popovic P, Paunesku T, Goodman CR, Woloschak G.. The effect of radiation on isogenic cervical cancer cell lines derived by the CRISPR/Cas9 editing of Epidermal Growth Factor Receptor (EGFR). Radiation Research Society (RRS), 2019.
- Popovic J, Paunesku T, Ibrahim M, Smith A, Goodman CR, Woloschak G.. The effect of radiation on isogenic cervical cancer cell lines derived by CRISPR/Cas9 editing of Epidermal Growth Factor Receptor. Radiation Research Society (RRS), 2019.
- Goodman CR, Popovic J, Quinn J, Paunesku T, Woloschak G. Nuclear delivery of radiosensitizing EGFR-targeted nanoparticles is abrogated in isogenic cervical cancer cell lines following mutagenesis of the ligand binding domain. International Journal of Radiation Oncology Biology Physics 105(1S):e677, 2019.
- Barry P, Hentz C, Albert A, Knoll M, Doke K, Masters A, Lee A, Dover L, Puckett L, Goodman C, Osborn V, Jagsi R. Society of Women in Radiation Oncology (SWRO) Perspective Piece/Inspirational Spotlight. Inaugural Women in Medicine Summit, 2019.
- Bajaj A, Petras K, Goodman CR, Donnelly ED, Hayes JP, Strauss JB. Cardiac Substructure Dose in Patients Undergoing Cardiac-Sparing Techniques for Whole Breast Radiotherapy or Partial Breast Irradiation: A Dosimetric Follow-Up to IMPORT LOW. International Journal of Radiation Oncology Biology Physics 111(S3):e204. e-Pub 2021.
- Seol SW, Pflederer T, Weller L, Goodman CR, Donnelly ED, Hayes JP, Strauss JB.. Radiotherapy versus endocrine therapy for hormone receptor positive early stage breast cancer accounting for endocrine therapy adherence. San Antonio Breast Cancer Symposium (SABCS). e-Pub 2021.
- Seol SW, Weller L, Pflederer T, Goodman CR, Donnelly ED, Hayes JP, Strauss JB. Avoidance of radiotherapy for low risk early breast cancer using LUMINA Trial criteria and accounting for endocrine therapy adherence. San Antonio Breast Cancer Symposium (SABCS). e-Pub 2021.
Book Chapters
- Goodman CR, Donnelly ED. Uterine Cervix. In: Radiation Oncology Management Decisions. 4. Lippincott Williams & Wilkins: Philadelphia, 2019.
- Goodman CR, Donnelly ED. Ovary and Fallopian Tube. In: Radiation Oncology Management Decisions. 4. Lippincott Williams & Wilkins: Philadelphia, 2019.
- Goodman CR, Smith BD. Radiotherapy for Locally Advanced Breast Cancer: Historical Review to Current Approaches. In: The Breast: Comprehensive Management of Benign and Malignant Diseases. 6. Elseviere, Inc: Philadelphia.
Grant & Contract Support
| Title: | |
| Funding Source: | Robert H. Lurie Clinical Cancer Center, Lurie Cancer Center Research Award |
| Role: | Mentored (Resident) Co-Investigator |
| Title: | Targeted therapy for the treatment of cervical cancer: utilizing nanoparticles to radiosensitize cancer cells |
| Funding Source: | The Brinson Foundation Medical Research Junior Investigator Award |
| Role: | Mentored (Resident) Principal Investigator |
| Title: | Radiotherapy for early-stage breast cancer based on circulating tumor cell status: feasibility of a prospective biomarker-directed cohort study |
| Funding Source: | The Friends of Prentice Grant Initiative |
| Role: | Mentored (Resident) Principal Investigator |
| Title: | Circulating tumor-derived material as a surrogate biomarker for radiotherapeutic efficacy in breast cancer |
| Funding Source: | American Society for Therapeutic Radiology and Oncology (ASTRO) |
| Role: | Principal Investigator |
| Title: | |
| Funding Source: | Institutional Start Up Funds, UT MD Anderson Cancer Center |
| Role: | Principal Investigator |
| Title: | Circulating tumor material as a surrogate biomarker for radiotherapy treatment response in breast cancer |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Molecular and genomic characterization of circulating tumor material serially collected throughout breast radiotherapy |
| Funding Source: | Institutional Research Grant, UT MD Anderson Cancer Center |
| Role: | Principal Investigator |