Chi Young Ok, M.D.

Peer-Reviewed Articles

1. Wang W, Routbort MJ, Ok CY, Patel KP, Sun Y, Kanagal-Shamanna R, Medeiros LJ, Wang SA. Characterization of TP53 mutations in clonal cytopenia of undetermined significance. Am J Hematol 92(8):E175-E177, 2017. e-Pub 2017. PMID: 28494520.
2. Ok CY, Young KH. Checkpoint inhibitors in hematological malignancies. J Hematol Oncol 10(1):103, 2017. e-Pub 2017. PMID: 28482851.
3. Ok CY, Young KH. Targeting the programmed death-1 pathway in lymphoid neoplasms. Cancer Treat Rev 54:99-109, 2017. e-Pub 2017. PMID: 28242522.
4. Jain P, Ok CY, Konoplev S, Patel KP, Jorgensen J, Estrov Z, Luthra R, Kantarjian H, Ravandi F. Relapsed Refractory BRAF-Negative, IGHV4-34-Positive Variant of Hairy Cell Leukemia: A Distinct Entity?. J Clin Oncol 34(7), 2016. e-Pub 2014. PMID: 24982452.
5. Loghavi S, Bueso-Ramos CE, Kanagal-Shamanna R, Young Ok C, Salim AA, Routbort MJ, Mehrotra M, Verstovsek S, Medeiros LJ, Luthra R, Patel KP. Myeloproliferative Neoplasms With Calreticulin Mutations Exhibit Distinctive Morphologic Features. Am J Clin Pathol 145(3):418-27, 2016. PMID: 27124925.
6. Ok CY, Leventaki V, Wang SA, Dinardo C, Medeiros LJ, Konoplev S. Detection of an Abnormal Myeloid Clone by Flow Cytometry in Familial Platelet Disorder With Propensity to Myeloid Malignancy. Am J Clin Pathol 145(2):271-6, 2016. e-Pub 2016. PMID: 26800764.
7. Ok CY, Singh RR, Salim AA. Single-Cell Quantitative PCR: Advances and Potential in Cancer Diagnostics. Methods Mol Biol 1392:153-9, 2016. PMID: 26843054.
8. Ohanian M, Bueso-Ramos C, Ok CY, Lin P, Patel K, Alattar ML, Khoury JD, Rozovski U, Estrov Z, Huh YO, Cortes J, Abruzzo LV. Acute myeloid leukemia with MYC rearrangement and JAK2 V617F mutation. Cancer Genet 208(11):571-4, 2015. e-Pub 2015. PMID: 26382622.
9. Wang W, Cortes JE, Lin P, Beaty MW, Ai D, Amin HM, McDonnell TJ, Ok CY, Kantarjian HM, Medeiros LJ, Hu S. Clinical and prognostic significance of 3q26.2 and other chromosome 3 abnormalities in CML in the era of tyrosine kinase inhibitors. Blood 126(14):1699-706, 2015. e-Pub 2015. PMID: 26243778.
10. Yabe M, Medeiros LJ, Wang SA, Konoplev S, Ok CY, Loghavi S, Lu G, Flores L, Khoury JD, Cason RC, Young KH, Miranda RN. Clinicopathologic, Immunophenotypic, Cytogenetic, and Molecular Features of γδ T-Cell Large Granular Lymphocytic Leukemia: An Analysis of 14 Patients Suggests Biologic Differences With γδ T-Cell Large Granular Lymphocytic Leukemia. Am J Clin Pathol 144(4):607-19, 2015. PMID: 26386082.
11. Li L, Xu-Monette ZY, Ok CY, Tzankov A, Manyam GC, Sun R, Visco C, Zhang M, Montes-Moreno S, Dybkaer K, Chiu A, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WW, van Krieken JH, Huh J, Ponzoni M, Ferreri AJ, Møller MB, Wang J, Parsons BM, Winter JN, Piris MA, Pham LV, Medeiros LJ, Young KH. Prognostic impact of c-Rel nuclear expression and REL amplification and crosstalk between c-Rel and the p53 pathway in diffuse large B-cell lymphoma. Oncotarget 6(27):23157-80, 2015. PMID: 26324762.
12. Ok CY, Xu-Monette ZY, Li L, Manyam GC, Montes-Moreno S, Tzankov A, Visco C, Dybkær K, Routbort MJ, Zhang L, Chiu A, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WW, van Krieken JH, Huh J, Ponzoni M, Ferreri AJ, Parsons BM, Rao H, Møller MB, Winter JN, Piris MA, Wang SA, Medeiros LJ, Young KH. Evaluation of NF-κB subunit expression and signaling pathway activation demonstrates that p52 expression confers better outcome in germinal center B-cell-like diffuse large B-cell lymphoma in association with CD30 and BCL2 functions. Mod Pathol 28(9):1202-13, 2015. e-Pub 2015. PMID: 26111978.
13. Ok CY, Ye Q, Li L, Manyam GC, Deng L, Goswami RR, Wang X, Montes-Moreno S, Visco C, Tzankov A, Dybkaer K, Zhang L, Abramson J, Sohani AR, Chiu A, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WW, van Krieken JH, Huh J, Ponzoni M, Ferreri AJ, Zhang S, Parsons BM, Xu M, Møller MB, Winter JN, Piris MA, Xu-Monette ZY, Medeiros LJ, Young KH. Age cutoff for Epstein-Barr virus-positive diffuse large B-cell lymphoma--is it necessary?. Oncotarget 6(16):13933-45, 2015. PMID: 26101854.
14. Cleven AH, Nardi V, Ok CY, Goswami M, Dal Cin P, Zheng Z, Iafrate AJ, Abdul Hamid MA, Wang SA, Hasserjian RP. High p53 protein expression in therapy-related myeloid neoplasms is associated with adverse karyotype and poor outcome. Mod Pathol 28(4):552-63, 2015. e-Pub 2014. PMID: 25412846.
15. Ok CY, Patel KP, Garcia-Manero G, Routbort MJ, Fu B, Tang G, Goswami M, Singh R, Kanagal-Shamanna R, Pierce SA, Young KH, Kantarjian HM, Medeiros LJ, Luthra R, Wang SA. Mutational profiling of therapy-related myelodysplastic syndromes and acute myeloid leukemia by next generation sequencing, a comparison with de novo diseases. Leuk Res 39(3):348-54, 2015. e-Pub 2014. PMID: 25573287.
16. Ok CY, Patel KP, Garcia-Manero G, Routbort MJ, Peng J, Tang G, Goswami M, Young KH, Singh R, Medeiros LJ, Kantarjian HM, Luthra R, Wang SA. TP53 mutation characteristics in therapy-related myelodysplastic syndromes and acute myeloid leukemia is similar to de novo diseases. J Hematol Oncol 8:45, 2015. e-Pub 2015. PMID: 25952993.
17. Ok CY, Chen J, Xu-Monette ZY, Tzankov A, Manyam GC, Li L, Visco C, Montes-Moreno S, Dybkær K, Chiu A, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WW, van Krieken JH, Huh J, Zhao X, Ponzoni M, Ferreri AJ, Bertoni F, Farnen JP, Møller MB, Piris MA, Winter JN, Medeiros LJ, Young KH. Clinical implications of phosphorylated STAT3 expression in De Novo diffuse large B-cell lymphoma. Clin Cancer Res 20(19):5113-23, 2014. e-Pub 2014. PMID: 25124685.
18. Ok CY, Wang SA, Amin HM. Leukemic phase of ALK(+) anaplastic large-cell lymphoma, small-cell variant: clinicopathologic pitfalls of a rare entity. Clin Lymphoma Myeloma Leuk 14(4):e123-6, 2014. e-Pub 2014. PMID: 24685107.
19. Ok CY, Yin CC, Yabe M, Bueso-Ramos CE, Miranda RN, Medeiros LJ, Konoplev SN. Lymphoma with features intermediate between aggressive T-large granular lymphocytic leukemia and hepatosplenic T-cell lymphoma: a diagnostic dilemma?. Clin Lymphoma Myeloma Leuk 14(3):e95-e100, 2014. e-Pub 2014. PMID: 24524924.
20. Strati P, Manning JT, Ok CY, Garcia-Manero G, Estrov Z. Interaction between myelomonocytic and lymphoid cells in a patient with acute myelomonocytic leukemia and chronic lymphocytic leukemia. Leuk Lymphoma 55(6):1425-7, 2014. e-Pub 2014. PMID: 23987820.
21. Ok CY, Xu-Monette ZY, Tzankov A, O'Malley DP, Montes-Moreno S, Visco C, Møller MB, Dybkaer K, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Han van Krieken J, Ponzoni M, Farnen JP, Piris MA, Winter JN, Medeiros LJ, Young KH. Prevalence and clinical implications of cyclin D1 expression in diffuse large B-cell lymphoma (DLBCL) treated with immunochemotherapy: a report from the International DLBCL Rituximab-CHOP Consortium Program. Cancer 120(12):1818-1829, 2014. e-Pub 2014. PMID: 24648050.
22. Ok CY, Li L, Xu-Monette ZY, Visco C, Tzankov A, Manyam GC, Montes-Moreno S, Dybkaer K, Dybaer K, Chiu A, Orazi A, Zu Y, Bhagat G, Chen J, Richards KL, Hsi ED, Choi WW, van Krieken JH, Huh J, Ai W, Ponzoni M, Ferreri AJ, Farnen JP, Møller MB, Bueso-Ramos CE, Miranda RN, Winter JN, Piris MA, Medeiros LJ, Young KH. Prevalence and clinical implications of epstein-barr virus infection in de novo diffuse large B-cell lymphoma in Western countries. Clin Cancer Res 20(9):2338-2349, 2014. e-Pub 2014. PMID: 24583797.
23. Fu B, Ok CY, Goswami M, Xei W, Jaso JM, Muzzafar T, Bueso-Ramos C, Verstovsek S, Garcia-Manero G, Medeiros LJ, Wang SA. The clinical importance of moderate/severe bone marrow fibrosis in patients with therapy-related myelodysplastic syndromes. Ann Hematol 92(10):1335-43, 2013. e-Pub 2013. PMID: 23660629.
24. Ok CY, Papathomas TG, Medeiros LJ, Young KH. EBV-positive diffuse large B-cell lymphoma of the elderly. Blood 122(3):328-40, 2013. e-Pub 2013. PMID: 23649469.
25. Yu H, Ok CY, Hesse A, Nordell P, Connor D, Sjostedt E, Pechet L, Snyder LM. Evaluation of an automated digital imaging system, Nextslide Digital Review Network, for examination of peripheral blood smears. Arch Pathol Lab Med 136(6):660-7, 2012. PMID: 22646275.
26. Ok CY, Akalin A. Gastric heterotopia in the rectum. Journal of Medical Cases 3(2):113-115, 2012.
27. Nardi V, Winkfield KM, Ok CY, Niemierko A, Kluk MJ, Attar EC, Garcia-Manero G, Wang SA, Hasserjian RP. Acute myeloid leukemia and myelodysplastic syndromes after radiation therapy are similar to de novo disease and differ from other therapy-related myeloid neoplasms(30):2340-7, 2012.
28. Ok CY, Singh RR, Vega F. Aberrant activation of the hedgehog signaling pathway in malignant hematological neoplasms. Am J Pathol 180(1):2-11, 2012. e-Pub 2011. PMID: 22056910.
29. Ok CY, Medeiros LJ, Hu Y, Bueso-Ramos CE, Wang SA. Transient/reversible ring sideroblasts in bone marrow of patients post cytotoxic therapies for primary malignancies. Leuk Res 35(12):1605-10, 2011. e-Pub 2011. PMID: 21596435.
30. Hao S, Smith TW, Chu PG, Liu Q, Ok CY, Woda BA, Lu D, Lin P, Wang SA, Dresser K, Rock KL, Jiang Z. The oncofetal protein IMP3: a novel molecular marker to predict aggressive meningioma. Arch Pathol Lab Med 135(8):1032-6, 2011. PMID: 21809995.
31. Ok CY, Loghavi S, Salim AA, Luthra R, Routbor MJ, Singh RR, Zuo Z, Wang SA, Jorgensen JL, FC, Kanagal-Shamanna R, Yin CC, Dinardo C, Pierce S, Garcia-Manero G, Kantarjian HM, Cortes JE, Ravandi F, Andreeff M, Medeiros LJ and Patel KP. DNMT3A mutation independently predicts relapse in patients with acute myeloid leukemia in morphologic remission.
32. Xia Y, Xu-Monette ZY, Tzankov A, Li X, Manyam GC, Murty V, Bhagat G, Zhang S, Pasqualucci L, Zhang L, Visco C, Dybkaer K, Chiu A, Orazi A, Zu Y, Richards KL, Hsi ED, Choi WW, van Krieken JH, Huh J, Ponzoni M, Ferreri AJ, Møller MB, Parsons BM, Winter JN, Piris MA, Westin J, Fowler N, Miranda RN, Ok CY, Li J, Medeiros LJ, Young KH. Loss of PRDM1/BLIMP-1 function contributes to poor prognosis for activated B-cell-like diffuse large B-cell lymphoma. Leukemia. e-Pub 2016. PMID: 27568520.

Invited Articles

1. Ok CY, Li L, Young KH. EBV-driven B-cell lymphoproliferative disorders: from biology, classification and differential diagnosis to clinical management. Exp Mol Med 47:e132, 2015. e-Pub 2015. PMID: 25613729.

Editorials

1. Ok CY, Young KH. Age cutoff in lymphoma diagnosis. Aging (Albany NY) 7(7):451-2, 2015. PMID: 26187891.

Abstracts

1. OK CY, Yang H, Villarreal J, Barkoh BA, Routbort MJ, Singh RR, Mantha GS, Lu H, Medeiros LJ, Luthra R, Patel KP. Development of a decision support system for specimen accessioning and uniform triaging of oncologic molecular testing, 2015.
2. OK CY. Salim AA, Loghavi S, Luthra R, Routbort MJ, Singh RR, Zuo Z, Medeiros LJ, Patel KP. Solving a 10-year old enigma with next generation sequencing-based assay, 2015.
3. OK CY, Loghavi S, Salim AA, Chen H, Kanagal-Shamanna R, Chowdhuri SR, Broaddus RR, Lazar AJ, Rashid A, Manekia JH, Barkoh BA, Medeiros LJ, Singh RR, Routbort MJ, Luthra R, Patel KP. To confirm and not to confirm, that is the question for equivocal NGS findings, 2015.
4. Ok CY, Salim AA, Luthra R, Patel KP. Next Generation Sequencing-based Monitoring for Minimal Residual Disease in Acute Myeloid Leukemia. Clinical Lymphoma Myeloma & Leukemia-20th International Hematologic Malignancies 2014 Conference 15(Supplement 1):S196-S196, 2015.
5. Ok CY, Salim AA, Loghavi S, Luthra R, Routbort MJ, Singh RR, Zuo Z, Pierce S, Garcia-Manero G, Kantarjian HM, Cortes JE, Ravandi F, Andreef M, Medeiros LJ, Patel KP. DNMT3A Mutation as a Molecular Marker for Monitoring Minimal Residual Disease in Acute Myeloid Leukemia. Modern Pathology-104th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP) 28(Supplement 2):370A, 2015.
6. Ok CY, Xu-Monette ZY, Tzankov A, Visco C, Montes-Moreno S, Dybkær K, Chiu A, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WWL, van Krieken JH, Huang Q, Huh J, Ai W, Ponzoni M, Ferreri AJM, Farnen JP, Møller MB, Winter JN, Piris MA, Medeiros LJ, Young KH.. Clinical Implications of Phosphorylated STAT3 Expression in De Novo Diffuse Large B-cell Lymphoma. Clin Cancer Res 20(19):5113-5123, 2014. e-Pub 2014. PMID: 25124685.
7. Ok CY, Xu-Monette ZY, Visco C, Tzankov A, Montes-Moreno S, Dybkær K, Chiu A, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WWL, van Krieken JH, Huh J, Ai W, Ponzoni M, Ferreri AJM, Farnen JP, Møller MB, Bueso-Ramos CE, Winter JN, Piris MA, Medeiros LJ, Young KH. Prevalence and Clinical Implications of Epstein-Barr Virus Infection in de novo Diffuse Large B-Cell Lymphoma in Western Countries: A report from The International DLBCL Rituximab-CHOP Consortium. Clinical Lymphoma Myeloma & Leukemia-9th International Hematologic Malignancies 2013 Conference 14(Supplement 3):S144-S145, 2014.
8. Ok CY, Tzankov A, Orazi A, Bhagat G, Hsi ED, Ponzoni M, Møller MB, Piris MA, Medeiros LJ, Young KH. Single Nucleotide Variation (SNV) of PRDM1 and Clinical Impact in De Novo Diffuse Large B cell Lymphoma: A Report from the International DLBCL Rituximab-CHOP Consortium Program Study, 2014.
9. Ok CY, Tzankov A, Orazi A, Bhagat G, Hsi ED, Ponzoni M, Møller MB, Piris MA, Medeiros LJ, Young KH. Immunohistochemical profiling of NF-κB subunit components in diffuse large B-cell lymphoma: A Report from the International DLBCL Rituximab-CHOP Consortium Program Study, 2014.
10. Ok CY, Patel KP, Wang SA, Routbort MJ, Fu B, Singh R, Kanagal-Shamanna R, LJ, Luthra R. Multigene Mutational Analysis Using Next Generation Sequencing (NGS) of 484 Patients with Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS). Laboratory Investigation-103rd Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP) 94(Supplement 1):367A, 2014.
11. Ok CY, Zuo Z, Garcia-Manero G, Medeiros LJ, Wang SA. Implications of Using the Revised International Prognostic Scoring System (IPSS-R) For Patients with Therapy-related Neoplasms. Laboratory Investigation-102nd Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP) 93(Supplement 1):354A, 2013.
12. Hamdi, A (Hamdi, Amir)[ 1 ] ; Ok, CY (Ok, Chi Young)[ 1 ] ; Rondon, G (Rondon, Gabriela)[ 1 ] ; Wang, SA (Wang, Sa A.)[ 1 ] ; Ravandi, F (Ravandi, Farhad)[ 1 ] ; Medeiros, LJ (Medeiros, L. Jeffrey)[ 1 ] ; Champlin, RE (Champlin, Richard E.)[ 1 ] ; Jorgensen, JL (Jorgensen, Jeffrey L.)[ 1 ] ; Kebriaei, P (Kebriaei, Partow). Mixed phenotype acute leukemia: experience in a single institution. Biology of Blood & Marrow Transplantation-BMT Tandem Meetings 19(Supplement 2):S224-S224, 2013.
13. Ok CY, Huh YO. Case #309, 2013.
14. Ok CY, Huh YO. Case #84, 2013. e-Pub 2013.
15. Ok CY, Wang SA. Case #83, 2013.
16. Ok CY, Welch M, Tomaszewicz K, Hutchinson L, Cosar EF. KRAS mutations in lipomas, atypical lipomatous tumors/well-differentiated liposarcomas (ALT) and dedifferentiated liposarcoma (DDLS). Laboratory Investigation-101st Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP) 92(Supplement 1):18A, 2012.
17. Ok CY, Zhou Y, Hu Y, Medeiros LJ, Wang SA. Ring sideroblasts and a normal karyotype in bone marrow of patients treated for primary malignancies and developed cytopenia. Modern Pathology-101st Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP) 25(Supplement 2):358A, 2012.
18. Ok CY, Walter O, Hutchinson L, Belkin E, Wassef W, Woda B, Cosar E. KRAS mutation analysis is a good adjunct to cytologic evaluation of pancreatic cyst fluids, 2011.
19. Ok CY, Yu H, Hesse A, Snyder LM, Connor D, Sjostedt E, Pechet L, Nordell P. Evaluation of an Automated Digital Image System, Nextslide Digital Review Network, for Examination of Peripheral Blood Smears. American Journal of Clinical Pathology 134(4):690-691, 2010.

Book Chapters

1. Ok CY, Salim AA, Singh RR. In: Single cell quantitative PCR – advances and potential in cancer diagnostics.

Letters to the Editor

1. Ok CY, Hasserjian RP, Fox PS, Stingo F, Zuo Z, Young KH, Patel K, Medeiros LJ, Garcia-Manero G, Wang SA. Application of the International Prognostic Scoring System-Revised in therapy-related myelodysplastic syndromes and oligoblastic acute myeloid leukemia. Leukemia 28: 185-9, 2014.