Chris Brosey
Department of Molecular and Cellular Oncology, Division of Division of Discovery Science
Present Title & Affiliation
Primary Appointment
Instructor, Department of Molecular and Cellular Oncology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2011 | Vanderbilt University, Nashville, TN, USA, PHD, Biochemistry |
| 2005 | Lipscomb University, Nashville, TN, USA, BA, Biology & Physics |
Postgraduate Training
| 2012-2016 | Research Fellowship, Biochemistry/X-ray crystallography, Washington University School of Medicine, St. Louis, MO |
| 2011-2012 | Research Fellowship, Biochemistry/Structural Biology, Vanderbilt University, Nashville, TN |
Experience & Service
Other Appointments/Responsibilities
Research Scientist, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 2016 - 2018
Consultantships
Project Manager and Consultant, The BALSA Group, St. Louis, MO, 2015 - 2016
Honors & Awards
| 2012 | The Karpay Award in Structural Biology, Vanderbilt University |
| 2009 | NIH Delegate to 59th Lindau Meeting, Lindau Meeting of Nobel Laureates |
Selected Publications
Peer-Reviewed Articles
- Brosey CA, Ho C, Long WZ, Singh S, Burnett K, Hura GL, Nix JC, Bowman GR, Ellenberger T, Tainer JA. Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor. Structure 24(12):2067-2079, 2016. e-Pub 2016. PMID: 27818101.
- Brosey CA, Soss SE, Brooks S, Yan C, Ivanov I, Dorai K, Chazin WJ. Functional dynamics in replication protein A DNA binding and protein recruitment domains. Structure 23(6):1028-38, 2015. e-Pub 2015. PMID: 26004442.
- Kim IK, Stegeman RA, Brosey CA, Ellenberger T. A quantitative assay reveals ligand specificity of the DNA scaffold repair protein XRCC1 and efficient disassembly of complexes of XRCC1 and the poly(ADP-ribose) polymerase 1 by poly(ADP-ribose) glycohydrolase. J Biol Chem 290(6):3775-83, 2015. e-Pub 2014. PMID: 25477519.
- Brosey CA, Yan C, Tsutakawa SE, Heller WT, Rambo RP, Tainer JA, Ivanov I, Chazin WJ. A new structural framework for integrating replication protein A into DNA processing machinery. Nucleic Acids Res 41(4):2313-27, 2013. e-Pub 2013. PMID: 23303776.
- Pretto DI, Tsutakawa S, Brosey CA, Castillo A, Chagot ME, Smith JA, Tainer JA, Chazin WJ. Structural dynamics and single-stranded DNA binding activity of the three N-terminal domains of the large subunit of replication protein A from small angle X-ray scattering. Biochemistry 49(13):2880-9, 2010. PMID: 20184389.
- Brosey CA, Chagot ME, Ehrhardt M, Pretto DI, Weiner BE, Chazin WJ. NMR analysis of the architecture and functional remodeling of a modular multidomain protein, RPA. J Am Chem Soc 131(18):6346-7, 2009. PMID: 19378948.
- Yengo CM, Ananthanarayanan SK, Brosey CA, Mao S, Tyska MJ. Human deafness mutation E385D disrupts the mechanochemical coupling and subcellular targeting of myosin-1a. Biophys J 94(2):L5-7, 2008. e-Pub 2007. PMID: 17981900.
Invited Articles
- Moiani D, Ronato DA, Brosey CA, Arvai AS, Syed A, Masson JY, Petricci E, Tainer JA. Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities. Methods Enzymol 601:205-241, 2018. e-Pub 2018. PMID: 29523233.
- Brosey CA, Ahmed Z, Lees-Miller SP, Tainer JA. What Combined Measurements From Structures and Imaging Tell Us About DNA Damage Responses. Methods Enzymol 592:417-455, 2017. e-Pub 2017. PMID: 28668129.
- Brosey CA, Chagot ME, Chazin WJ. Preparation of the modular multi-domain protein RPA for study by NMR spectroscopy. Methods Mol Biol 831:181-95, 2012. PMID: 22167675.
- Brosey CA, Tsutakawa SE, Chazin WJ. Sample preparation methods to analyze DNA-induced structural changes in replication protein A. Methods Mol Biol 922:101-22, 2012. PMID: 22976179.
Grant & Contract Support
| Title: | Determining the structural basis for AIF release during poly(ADP-ribose)-induced cell death |
| Funding Source: | NIH/NIGMS |
| Role: | Postdoctoral Fellow |
| Title: | Molecular Biophysics Training Grant at Vanderbilt University |
| Funding Source: | NIH/NIGMS |
| Role: | Trainee |
| Title: | PHARMACOLOGICAL MODULATION OF POLY(ADP-RIBOSE) METABOLISM |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Recruitment of Established Investigator |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Research Scientist |
| Title: | BRCA Answers from Cancer Interactome Structures (BACIS) |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Co-Investigator |
Patient Reviews
CV information above last modified June 27, 2022