Christine M. Parseghian, MD
Department of Gastrointestinal Medical Oncology, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Gastrointestinal (GI) Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, Houston, TX
Education & Training
Degree-Granting Education
| 2012 | Tufts University School of Medicine, Boston, MA, USA, MD, Doctor of Medicine with Research Honors |
| 2007 | Harvard University, Cambridge, MA, USA, BA, Neurobiology |
Postgraduate Training
| 2015-2018 | Clinical Fellowship, Hematology/Oncology Fellow, U.T. MD Anderson Cancer Center, Houston, TX |
| 2012-2015 | Clinical Residency, Internal Medicine Residency, Ronald Reagan University of California, Los Angeles, CA |
Board Certifications
| 2016 | American Board of Internal Medicine |
Experience & Service
Institutional Committee Activities
Fellow, Dolores Zohrab Liebmann Fellow in Graduate Studies, 2008 - 2012
Community Service, Leopold Schepp Foundation Scholar for commitment to community service, 2008 - 2009
Fellow, David F. Noonan Tufts Summer Research, 2008 - 2009
Clinical Assistant, USAID and Armenian Medical Association, 2005 - 2006
Honors & Awards
| 2018 | 2018 Conquer Cancer Foundation of ASCO Merit Award |
| 2013 | Commendation for Excellence in Medical Student Teaching |
| 2012 | Solomon Research Scholar |
| 2012 | Tufts University School of Medicine Research Honors |
| 2012 | William Dameshek Award for Research Excellence in Hematology |
| 2012 | William Dameshek Award in Internal Medicine |
| 2007 | Harvard Foundation Distinguished Senior Award for Excellence in Leadership and Academic Achievement |
| 2005 | Harvard Foundation Award for Contributions to Intercultural and Race Relations |
Selected Publications
Peer-Reviewed Articles
- Shen C, Tannenbaum D, Horn R, Rogers J, Eng C, Zhou S, Johnson B, Kopetz S, Morris V, Overman M, Parseghian C, Chang GJ, Lopez-Olivo MA, Kanwal R, Ellis LM, Dasari A. Overall Survival in Phase 3 Clinical Trials and the Surveillance, Epidemiology, and End Results Database in Patients With Metastatic Colorectal Cancer, 1986-2016: A Systematic Review. JAMA Netw Open 5(5):e2213588, 2022. e-Pub 2022. PMID: 35608860.
- Morris V, Kee B, Overman M, Dasari A, Raghav K, Johnson B, Parseghian C, Wolff RA, Garg N, Eng C, Kopetz S. Clinical and pathologic features correlated with rare favorable survival in patients with BRAFV600E mutated colorectal cancer. J Gastrointest Oncol 13(2):647-656, 2022. PMID: 35557581.
- Kanikarla Marie P, Haymaker C, Parra ER, Kim YU, Lazcano R, Gite S, Lorenzini D, Wistuba II, Tidwell RSS, Song X, Foo WC, Maru DM, Chun YS, Futreal A, Kee B, Menter D, Solis L, Tzeng CW, Parseghian C, Raghav K, Morris V, Chang CC, Jenq R, Tam A, Bernatchez C, Kopetz S, Vauthey JN, Overman MJ. Pilot Clinical Trial of Perioperative Durvalumab and Tremelimumab in the Treatment of Resectable Colorectal Cancer Liver Metastases. Clin Cancer Res 27(11):3039-3049, 2021. e-Pub 2021. PMID: 33811152.
- Favazza LA, Parseghian CM, Kaya C, Nikiforova MN, Roy S, Wald AI, Landau MS, Proksell SS, Dueker JM, Johnston ER, Brand RE, Bahary N, Gorantla VC, Rhee JC, Pingpank JF, Choudry HA, Lee K, Paniccia A, Ongchin MC, Zureikat AH, Bartlett DL, Singhi AD. KRAS amplification in metastatic colon cancer is associated with a history of inflammatory bowel disease and may confer resistance to anti-EGFR therapy. Mod Pathol 33(9):1832-1843, 2020. e-Pub 2020. PMID: 32376853.
- Parseghian CM, Tam AL, Yao J, Ensor J, Ellis LM, Raghav K, Overman MJ. Assessment of Reported Trial Characteristics, Rate of Publication, and Inclusion of Mandatory Biopsies of Research Biopsies in Clinical Trials in Oncology. JAMA Oncol 5(3):402-405, 2019. e-Pub 2018. PMID: 30383128.
- Parseghian CM , Loree JM, Morris VK, Liu X, Clifton KK, Napolitano S, Henry JT, Pereira AA, Vilar E, Johnson B, Kee B, Raghav K, Dasari A, Wu J, Garg N, Raymond VM, Banks KC, Talasaz AA, Lanman RB, Strickler JH, Hong DS, Corcoran RB, Overman MJ, Kopetz S. Anti-EGFR resistant clones decay exponentially after progression: Implications for anti-EGFR rechallenge. Ann Oncol 30(2):243-249, 2019. PMID: 30462160.
- Parseghian CM , Patnana M, Bhosale P, Hess KR, Shih YT, Kim B, Kopetz S, Overman MJ, Varadhachary GR, Javle M, Naing A, Piha-Paul S, Hong D, Le H, Subbiah V, Pant S. Evaluating for Pseudoprogression in Colorectal and Pancreatic Tumors Treated With Immunotherapy. J Immunother 41(6):284-291, 2018. PMID: 29668571.
- Parseghian CM , Raghav K, Wolff RA, Ensor J, Yao J, Ellis LM, Tam AL, Overman MJ. Underreporting of Research Biopsies from Clinical Trials in Oncology. Clin Cancer Res 23(21):6450-6457, 2017. e-Pub 2017. PMID: 28754815.
- Parseghian CM, Parikh NU, Wu JY, Jiang ZQ, Henderson L, Tian F, Pastor B, Ychou M, Raghav K, Dasari A, Fogelman DR, Katsiampoura AD, Menter DG, Wolff RA, Eng C, Overman MJ, Thierry AR, Gallick GE, Kopetz S. Dual Inhibition of EGFR and c-Src by Cetuximab and Dasatinib Combined with FOLFOX Chemotherapy in Patients with Metastatic Colorectal Cancer. Clin Cancer Res 23(15):4146-4154, 2017. e-Pub 2017. PMID: 28280091.
- Thierry AR, Pastor B, Jiang ZQ, Katsiampoura AD, Parseghian CM , Loree JM, Overman MJ, Sanchez C, Messaoudi SE, Ychou M, Kopetz S. Circulating DNA Demonstrates Convergent Evolution and Common Resistance Mechanisms during Treatment of Colorectal Cancer. Clin Cancer Res 23(16):4578-4591, 2017. e-Pub 2017. PMID: 28400427.
- Megerdichian C, Olimpiadi Y, Hurvitz SA. nab-Paclitaxel in combination with biologically targeted agents for early and metastatic breast cancer. Cancer Treat Rev 40(5):614-25, 2014. e-Pub 2014. PMID: 24560997.
- Dutt S, Narla A, Lin K, Mullally A, Abayasekara N, Megerdichian CM, Wilson FH, Currie T, Khanna-Gupta A, Berliner N, Kutok JL, Ebert BL. Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells. Blood 117(9):2567-76, 2011. e-Pub 2010. PMID: 21068437.
- Mullally A, Lane SW, Ball B, Megerdichian C, Okabe R, Al-Shahrour F, Paktinat M, Haydu JE, Housman E, Lord AM, Wernig G, Kharas MG, Mercher T, Kutok JL, Gilliland DG, Ebert BL. Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells. Cancer Cell 17(6):584-96, 2010. PMID: 20541703.
- Megerdichian CL, Rees VW, Wayne GF, Connolly GN. Internal tobacco industry research on olfactory and trigeminal nerve response to nicotine and other smoke components. Nicotine Tob Res 9(11):1119-29, 2007. PMID: 17978985.
- Serpas Higbie V, Rogers J, Hwang H, Qiao W, Xiao L, Dasari A, Mola-Rudd K, Morris VK, Wolff RA, Raghav K, Huey R, Parseghian C, Willis J, Kopetz S, Overman MJ, Johnson B. Antibiotic Exposure Does Not Impact Immune Checkpoint Blockade Response in MSI-H/dMMR Metastatic Colorectal Cancer: A Single-Center Experience. Oncologist. e-Pub 2022. PMID: 35946836.
- Newhook TE, Overman MJ, Chun YS, Dasari A, Tzeng CD, Cao HST, Raymond V, Parseghian C, Johnson B, Nishioka Y, Kawaguchi Y, Uppal A, Vreeland TJ, Jaimovich A, Arvide EM, Cristo JV, Wei SH, Raghav KP, Morris VK, Lee JE, Kopetz S, Vauthey JN. Prospective Study of Perioperative Circulating Tumor DNA Dynamics in Patients Undergoing Hepatectomy for Colorectal Liver Metastases. Ann Surg. e-Pub 2022. PMID: 35797554.
- Ibraheim MK, Lo J, Gupta R, Parseghian C, Patel AB. Acneiform eruptions with combination targeted cancer therapy in colorectal cancer patients. Support Care Cancer. e-Pub 2022. PMID: 35771289.
Abstracts
- Parseghian CM, Vilar Sanchez E, Sun R, Eluri M, Morris VK, Johnson B, Morelli MP, Overman MJ, Willis J, Huey R, Raghav KP, Dasari A, Kee BK, Wolff RA, Shen JP, Kopetz S. Phase 2 Study of Anti-EGFR Rechallenge Therapy with Panitumumab with or without Trametinib in Advanced Colorectal Cancer. ASCO Annual Meeting, 6/2022 40(16), 2022.
- Christine Megerdichian Parseghian, Ryan Sun, Melanie Nicole Woods, Stefania Napolitano, Jumanah Alshenaifi, Jason Willis, ShaKayla Kentel Nunez, Alexey Sorokin, Preeti Kanikarla Marie, Kanwal Pratap Singh Raghav, Van K. Morris, John Paul Y.C. Shen, Eduardo Vilar Sanchez, Marko Rehn, Agnes Ang, Teresa Troiani, Scott Kopetz. Resistant Mechanisms to anti-EGFR Therapy in RAS/RAF Wildtype Colorectal Cancer Varies by Regimen and Line of Therapy. ASCO Annual Meeting, 6/2022 40(16), 2022.
- Parseghian CM, Willis J, Morris V, Raghav K, Dasari A, Raymond V, Lanman R, Overman MJ, Kopetz S. Identifying anti-EGFR (EGFRi) response subgroups using evidence of ctDNA selective pressure. ASCO Annual Meeting, 2019.
- Rich TA, Clifton K,Raymond VM, Dasari A, Raghav K, Parseghian CM , Lanman RB, Kopetz S, Morris VK. Association between gene fusions and anti-EGFR resistance signature in colorectal cancer. J Clin Oncol(3564), 2019.
- Horn RA, Tannenbaum D, Morris VK, Johnson B, Overman MJ, Parseghian CM, Scott Kopetz, Eng C, Rogers JE, Raghav K, Dasari A,. Reporting of patient characteristics and use of stratification factors in phase III trials for metastatic colorectal cancer: Urgent need for standardization. J Clin Oncol 37(suppl), 2019.
- Parseghian CM, Patnana M, Bhosale P, Hess K, Kopetz S, Overman MJ, Naing A, Piha-Paul SA, Subbiah V, Hong D, Le H, Pant S.. Evaluating for Pseudoprogression in Colorectal and Pancreatic Cancer Patients Treated with Immunotherapy. GI ESMO Annual Meeting, 2017.
Book Chapters
- Parseghian, CM. Colorectal Liver Metastases. In: Targeted Therapy Beyond EGFR and VEGF, 2022.
- Parseghian CM. Colorectal Cancer. In: The MD Anderson Manual of Medical Oncology. Fourth Edition, 2021.