C. Chad Quarles, Ph.D.
Department of Cancer Systems Imaging, Division of Diagnostic Imaging
Education & Training
Degree-Granting Education
| 2004 | Medical College of Wisconsin, Milwaukee, WI, USA, PHD, Biophysics |
| 1988 | Centenary College of Louisiana, Shreveport, LA, USA, BS, Biophysics |
Postgraduate Training
| 2004-2007 | Post-Doctoral Fellowship, Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN |
Experience & Service
Academic Appointments
Professor, Department of Cancer Systems Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 2022 - Present
Professor, Division of Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, 2018 - 2022
Director, Department of Barrow Neuroimaging Innovation Center, Barrow Neurological Institute, Phoenix, AZ, 2018 - 2022
Professor, Division of Neuroimaging Research, The University of Texas MD Anderson Cancer Center, Phoenix, AZ, 2018 - 2022
Associate Professor, Department of Departments of Radiology and Radiological Sciences, Departments of Biomedical Engineering, Physics and Astronomy, Cancer Biology and the Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN, 2015 - Present
Associate Professor, Department of Imaging Research, Barrow Neurological Institute, Phoenix, AZ, 2015 - 2018
Adjunct Professor, Division of School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, 2015 - 2022
Director, Department of Advanced Brain Tumor Imaging Program, Vanderbilt University Institute of Imaging Science, Nashville, TN, 2013 - 2015
Assistant Professor, Department of Departments of Radiology and Radiological, Departments of Radiology and Radiological Sciences, Biomedical Engineering, Physics and Astronomy, Cancer Biology and the Chemical and Physical Biology Program, Division of Departments of Radiology and Radiological Sciences, Biomedical Engineering, Physics and Astronomy, Cancer Biology and the Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN, 2008 - 2015
Scientific Director, Department of Mouse Kidney Imaging Core, Vanderbilt University Institute of Imaging Science, Nashville, TN, 2008 - 2015
Assistant Professor, Department of Radiology and Radiological Sciences, Division of Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, 2007 - 2008
Administrative Appointments/Responsibilities
Chair, Barrow Neurological Institute, Phoenix, AZ, 2021 - 2022
Other Appointments/Responsibilities
Co-Chair of Organizing Committee, International Society of Magnetic Resonance in Medicine Cancer Imaging Workshop: From Discovery to Diagnosis, Milan, 2021 - Present
Research Oversight Committee, Barrow Neurologic Institute, Nashville, 2018 - 2022
Member and Chair, International Society of Magnetic Resonance in Medicine, Milan, 2018 - 2022
Research Faculty Appointments and Promotions Commit, Barrow Neurological Institute, Nashville, TN, 2017 - 2022
Workshop and Study Group Review Committee, International Society of Magnetic Resonance in Medicine, Milan, 2017 - 2019
Co-Chair and Organizer, International Society of Magnetic Resonance in Medicine Meeting and Exhibition, Milan, 2014 - Present
Scientific Member, Vanderbilt University, Nashville, TN, 2013 - 2015
Session Chair, Quantitative Cancer Imaging Biomarkers, Nashville, TN, 2013 - Present
Chair, Vanderbilt University Institute of Imaging Science, Nashville, TN, 2010 - Present
Organizing Committee, Vanderbilt University Institute of Imaging Science, Nashville, TN, 2008 - 2009
Research Assistant, Centenary College of Louisiana Department of Biophysics, Shreveport, LA, 1996 - 1999
Honors & Awards
| 2019 | Outsanding Teacher Award, International Society of Magnetic Resonance in Medicine |
| 2006 | William G. Negendank Award, International Society of Magnetic Resonance in Medicine MR of Cancer Study Group Workshop: Frontiers in Metabolic, Molecular and Clinical Imaging, PA, USA |
| 2004 | Award for Cancer and Spectroscopy, International Society of Magnetic Resonance in Medicine |
| 2004 | NIH/NCI Cancer Imaging Post-doctoral Fellow, Department of Radiology and Radiological Sciences, Vanderbilt University |
| 2001 | Student/Postdoctoral Travel Stipend, International Society of Magnetic Resonance in Medicine |
| 1999 | National Science Foundation Graduate Research Fellowship |
| 1999 | Graduated summa cum laude |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Griffiths DR, Law LM, Young C, Fuentes A, Truran S, Karamanova N, Bell LC, Turner G, Emerson H, Mastroeni D, Gonzales RJ, Reaven PD, Quarles CC, Migrino RQ, Lifshitz J. Chronic Cognitive and Cerebrovascular Function Following Mild Traumatic Brain Injury in Rats. J Neurotrauma 39(19-20):1429-1441, 2022. e-Pub 2022. PMID: 35593008.
- McGarry SD, Brehler M, Bukowy JD, Lowman AK, Bobholz SA, Duenweg SR, Banerjee A, Hurrell SL, Malyarenko D, Chenevert TL, Cao Y, Li Y, You D, Fedorov A, Bell LC, Quarles CC, Prah MA, Schmainda KM, Taouli B, LoCastro E, Mazaheri Y, Shukla-Dave A, Yankeelov TE, Hormuth DA, Madhuranthakam AJ, Hulsey K, Li K, Huang W, Huang W, Muzi M, Jacobs MA, Solaiyappan M, Hectors S, Antic T, Paner GP, Palangmonthip W, Jacobsohn K, Hohenwalter M, Duvnjak P, Griffin M, See W, Nevalainen MT, Iczkowski KA, LaViolette PS. Multi-Site Concordance of Diffusion-Weighted Imaging Quantification for Assessing Prostate Cancer Aggressiveness. J Magn Reson Imaging 55(6):1745-1758, 2022. e-Pub 2021. PMID: 34767682.
- Hajji N, Garcia-Revilla J, Soto MS, Perryman R, Symington J, Quarles CC, Healey DR, Guo Y, Orta-Vázquez ML, Mateos-Cordero S, Shah K, Bomalaski J, Anichini G, Tzakos AG, Crook T, O'Neill K, Scheck AC, Venero JL, Syed N. Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors. J Clin Invest 132(6), 2022. PMID: 35113813.
- Harris DC, Mignucci-Jiménez G, Xu Y, Eikenberry SE, Quarles CC, Preul MC, Kuang Y, Kostelich EJ. Tracking glioblastoma progression after initial resection with minimal reaction-diffusion models. Math Biosci Eng 19(6):5446-5481, 2022. PMID: 35603364.
- Bell LC, Fuentes AE, Healey DR, Chao R, Bakkar N, Sirianni RW, Medina DX, Bowser RP, Ladha SS, Semmineh NB, Stokes AM, Quarles CC. Longitudinal evaluation of myofiber microstructural changes in a preclinical ALS model using the transverse relaxivity at tracer equilibrium (TRATE): A preliminary study. Magn Reson Imaging 85:217-221, 2022. e-Pub 2021. PMID: 34715291.
- Scarpelli ML, Healey DR, Mehta S, Quarles CC. Imaging Glioblastoma With 18F-Fluciclovine Amino Acid Positron Emission Tomography. Frontiers Oncol 12:829050, 2022. e-Pub 2022. PMID: 35174096.
- Stokes AM, Ragunathan S, Robison RK, Fuentes A, Bell LC, Karis JP, Pipe JG, Quarles CC. Development of a spiral spin- and gradient-echo (spiral-SAGE) approach for improved multi-parametric dynamic contrast neuroimaging. Magn Reson Med 86(6):3082-3095, 2021. e-Pub 2021. PMID: 34288112.
- Stokes AM, Bergamino M, Alhilali L, Hu LS, Karis JP, Baxter LC, Bell LC, Quarles CC. Evaluation of single bolus, dual-echo dynamic susceptibility contrast MRI protocols in brain tumor patients. J Cereb Blood Flow Metab 41(12):3378-3390, 2021. e-Pub 2021. PMID: 34415211.
- Belykh E, Jubran JH, George LL, Bardonova L, Healey DR, Georges JF, Quarles CC, Eschbacher JM, Mehta S, Scheck AC, Nakaji P, Preul MC. Molecular Imaging of Glucose Metabolism for Intraoperative Fluorescence Guidance During Glioma Surgery. Mol Imaging Biol 23(4):586-596, 2021. e-Pub 2021. PMID: 33544308.
- Barajas RF, Politi LS, Anzalone N, Schöder H, Fox CP, Boxerman JL, Kaufmann TJ, Quarles CC, Ellingson BM, Auer D, Andronesi OC, Ferreri AJM, Mrugala MM, Grommes C, Neuwelt EA, Ambady P, Rubenstein JL, Illerhaus G, Nagane M, Batchelor TT, Hu LS. Consensus recommendations for MRI and PET imaging of primary central nervous system lymphoma: guideline statement from the International Primary CNS Lymphoma Collaborative Group (IPCG). Neuro Oncol 23(7):1056-1071, 2021. PMID: 33560416.
- Ragunathan S, Bell LC, Semmineh N, Stokes AM, Shefner JM, Bowser R, Ladha S, Quarles CC. Evaluation of Amyotrophic Lateral Sclerosis-Induced Muscle Degeneration Using Magnetic Resonance-Based Relaxivity Contrast Imaging (RCI). Tomography 7(2):169-179, 2021. e-Pub 2021. PMID: 34062974.
- Scarpelli ML, Healey DR, Fuentes A, Kodibagkar VD, Quarles CC. Correlation of Tumor Hypoxia Metrics Derived from 18F-Fluoromisonidazole Positron Emission Tomography and Pimonidazole Fluorescence Images of Optically Cleared Brain Tissue. Tomography 6(4):379-388, 2020. PMID: 33364428.
- Sorace AG, Elkassem AA, Galgano SJ, Lapi SE, Larimer BM, Partridge SC, Quarles CC, Reeves K, Napier TS, Song PN, Yankeelov TE, Woodard S, Smith AD. Imaging for Response Assessment in Cancer Clinical Trials. Semin Nucl Med 50(6):488-504, 2020. e-Pub 2020. PMID: 33059819.
- Scarpelli ML, Healey DR, Mehta S, Kodibagkar VD, Quarles CC. A practical method for multimodal registration and assessment of whole-brain disease burden using PET, MRI, and optical imaging. Sci Rep 10(1):17324, 2020. e-Pub 2020. PMID: 33057180.
- Boxerman JL, Quarles CC, Hu LS, Erickson BJ, Gerstner ER, Smits M, Kaufmann TJ, Barboriak DP, Huang RH, Wick W, Weller M, Galanis E, Kalpathy-Cramer J, Shankar L, Jacobs P, Chung C, van den Bent MJ, Chang S, Al Yung WK, Cloughesy TF, Wen PY, Gilbert MR, Rosen BR, Ellingson BM, Schmainda KM, Jumpstarting Brain Tumor Drug Development Coalition Imaging Standardization Steering Committee. Consensus recommendations for a dynamic susceptibility contrast MRI protocol for use in high-grade gliomas. Neuro Oncol 22(9):1262-1275, 2020. PMID: 32516388.
- Bell LC, Semmineh N, An H, Eldeniz C, Wahl R, Schmainda KM, Prah MA, Erickson BJ, Korfiatis P, Wu C, Sorace AG, Yankeelov TE, Rutledge N, Chenevert TL, Malyarenko D, Liu Y, Brenner A, Hu LS, Zhou Y, Boxerman JL, Yen YF, Kalpathy-Cramer J, Beers AL, Muzi M, Madhuranthakam AJ, Pinho M, Johnson B, Quarles CC. Evaluating the Use of rCBV as a Tumor Grade and Treatment Response Classifier Across NCI Quantitative Imaging Network Sites: Part II of the DSC-MRI Digital Reference Object (DRO) Challenge. Tomography 6(2):203-208, 2020. PMID: 32548297.
- Hoxworth JM, Eschbacher JM, Gonzales AC, Singleton KW, Leon GD, Smith KA, Stokes AM, Zhou Y, Mazza GL, Porter AB, Mrugala MM, Zimmerman RS, Bendok BR, Patra DP, Krishna C, Boxerman JL, Baxter LC, Swanson KR, Quarles CC, Schmainda KM, Hu LS. Performance of Standardized Relative CBV for Quantifying Regional Histologic Tumor Burden in Recurrent High-Grade Glioma: Comparison against Normalized Relative CBV Using Image-Localized Stereotactic Biopsies. AJNR Am J Neuroradiol 41(3):408-415, 2020. e-Pub 2020. PMID: 32165359.
- Bell LC, Stokes AM, Quarles CC. Analysis of postprocessing steps for residue function dependent dynamic susceptibility contrast (DSC)-MRI biomarkers and their clinical impact on glioma grading for both 1.5 and 3T. J Magn Reson Imaging 51(2):547-553, 2020. e-Pub 2019. PMID: 31206948.
- Stokes AM, Semmineh NB, Nespodzany A, Bell LC, Quarles CC. Systematic assessment of multi-echo dynamic susceptibility contrast MRI using a digital reference object. Magn Reson Med 83(1):109-123, 2020. e-Pub 2019. PMID: 31400035.
- Hormuth DA, Sorace AG, Virostko J, Abramson RG, Bhujwalla ZM, Enriquez-Navas P, Gillies R, Hazle JD, Mason RP, Quarles CC, Weis JA, Whisenant JG, Xu J, Yankeelov TE. Translating preclinical MRI methods to clinical oncology. J Magn Reson Imaging 50(5):1377-1392, 2019. e-Pub 2019. PMID: 30925001.
- Lee MD, Baird GL, Bell LC, Quarles CC, Boxerman JL. Utility of Percentage Signal Recovery and Baseline Signal in DSC-MRI Optimized for Relative CBV Measurement for Differentiating Glioblastoma, Lymphoma, Metastasis, and Meningioma. AJNR Am J Neuroradiol 40(9):1445-1450, 2019. e-Pub 2019. PMID: 31371360.
- Schmainda KM, Prah MA, Hu LS, Quarles CC, Semmineh N, Rand SD, Connelly JM, Anderies B, Zhou Y, Liu Y, Logan B, Stokes A, Baird G, Boxerman JL. Moving Toward a Consensus DSC-MRI Protocol: Validation of a Low-Flip Angle Single-Dose Option as a Reference Standard for Brain Tumors. AJNR Am J Neuroradiol 40(4):626-633, 2019. e-Pub 2019. PMID: 30923088.
- Bell LC, Semmineh N, An H, Eldeniz C, Wahl R, Schmainda KM, Prah MA, Erickson BJ, Korfiatis P, Wu C, Sorace AG, Yankeelov TE, Rutledge N, Chenevert TL, Malyarenko D, Liu Y, Brenner A, Hu LS, Zhou Y, Boxerman JL, Yen YF, Kalpathy-Cramer J, Beers AL, Muzi M, Madhuranthakam AJ, Pinho M, Johnson B, Quarles CC. Evaluating Multisite rCBV Consistency from DSC-MRI Imaging Protocols and Postprocessing Software Across the NCI Quantitative Imaging Network Sites Using a Digital Reference Object (DRO). Tomography 5(1):110-117, 2019. PMID: 30854448.
- Quarles CC, Bell LC, Stokes AM. Imaging vascular and hemodynamic features of the brain using dynamic susceptibility contrast and dynamic contrast enhanced MRI. Neuroimage 187:32-55, 2019. e-Pub 2018. PMID: 29729392.
- Wang F, Katagiri D, Li K, Takahashi K, Wang S, Nagasaka S, Li H, Quarles CC, Zhang MZ, Shimizu A, Gore JC, Harris RC, Takahashi T. Assessment of renal fibrosis in murine diabetic nephropathy using quantitative magnetization transfer MRI. Magn Reson Med 80(6):2655-2669, 2018. e-Pub 2018. PMID: 29845659.
- Semmineh NB, Bell LC, Stokes AM, Hu LS, Boxerman JL, Quarles CC. Optimization of Acquisition and Analysis Methods for Clinical Dynamic Susceptibility Contrast MRI Using a Population-Based Digital Reference Object. AJNR Am J Neuroradiol 39(11):1981-1988, 2018. e-Pub 2018. PMID: 30309842.
- Woodall RT, Barnes SL, Hormuth DA, Sorace AG, Quarles CC, Yankeelov TE. The effects of intravoxel contrast agent diffusion on the analysis of DCE-MRI data in realistic tissue domains. Magn Reson Med 80(1):330-340, 2018. e-Pub 2017. PMID: 29115690.
- Schmainda KM, Prah MA, Rand SD, Liu Y, Logan B, Muzi M, Rane SD, Da X, Yen YF, Kalpathy-Cramer J, Chenevert TL, Hoff B, Ross B, Cao Y, Aryal MP, Erickson B, Korfiatis P, Dondlinger T, Bell L, Hu L, Kinahan PE, Quarles CC. Multisite Concordance of DSC-MRI Analysis for Brain Tumors: Results of a National Cancer Institute Quantitative Imaging Network Collaborative Project. AJNR Am J Neuroradiol 39(6):1008-1016, 2018. e-Pub 2018. PMID: 29794239.
- Barry RL, Byun NE, Tantawy MN, Mackey CA, Wilson GH, Stark AJ, Flom MP, Gee LC, Quarles CC. In vivo neuroimaging and behavioral correlates in a rat model of chemotherapy-induced cognitive dysfunction. Brain Imaging Behav 12(1):87-95, 2018. PMID: 28108946.
- Newitt DC, Malyarenko D, Chenevert TL, Quarles CC, Bell L, Fedorov A, Fennessy F, Jacobs MA, Solaiyappan M, Hectors S, Taouli B, Muzi M, Kinahan PE, Schmainda KM, Prah MA, Taber EN, Kroenke C, Huang W, Arlinghaus LR, Yankeelov TE, Cao Y, Aryal M, Yen YF, Kalpathy-Cramer J, Shukla-Dave A, Fung M, Liang J, Boss M, Hylton N. Multisite concordance of apparent diffusion coefficient measurements across the NCI Quantitative Imaging Network. J Med Imaging (Bellingham) 5(1):011003, 2018. e-Pub 2017. PMID: 29021993.
- Malyarenko D, Fedorov A, Bell L, Prah M, Hectors S, Arlinghaus L, Muzi M, Solaiyappan M, Jacobs M, Fung M, Shukla-Dave A, McManus K, Boss M, Taouli B, Yankeelov TE, Quarles CC, Schmainda K, Chenevert TL, Newitt DC. Toward uniform implementation of parametric map Digital Imaging and Communication in Medicine standard in multisite quantitative diffusion imaging studies. J Med Imaging (Bellingham) 5(1):011006, 2018. e-Pub 2017. PMID: 29134189.
- Bell LC, Does MD, Stokes AM, Baxter LC, Schmainda KM, Dueck AC, Quarles CC. Optimization of DSC MRI Echo Times for CBV Measurements Using Error Analysis in a Pilot Study of High-Grade Gliomas. AJNR Am J Neuroradiol 38(9):1710-1715, 2017. e-Pub 2017. PMID: 28684456.
- Bell LC, Hu LS, Stokes AM, McGee SC, Baxter LC, Quarles CC. Characterizing the Influence of Preload Dosing on Percent Signal Recovery (PSR) and Cerebral Blood Volume (CBV) Measurements in a Patient Population With High-Grade Glioma Using Dynamic Susceptibility Contrast MRI. Tomography 3(2):89-95, 2017. PMID: 28825039.
- Semmineh NB, Stokes AM, Bell LC, Boxerman JL, Quarles CC. A Population-Based Digital Reference Object (DRO) for Optimizing Dynamic Susceptibility Contrast (DSC)-MRI Methods for Clinical Trials. Tomography 3(1):41-49, 2017. PMID: 28584878.
- Sorace AG, Syed AK, Barnes SL, Quarles CC, Sanchez V, Kang H, Yankeelov TE. Quantitative [18F]FMISO PET Imaging Shows Reduction of Hypoxia Following Trastuzumab in a Murine Model of HER2+ Breast Cancer. Mol Imaging Biol 19(1):130-137, 2017. PMID: 27506906.
- Hu LS, Ning S, Eschbacher JM, Baxter LC, Gaw N, Ranjbar S, Plasencia J, Dueck AC, Peng S, Smith KA, Nakaji P, Karis JP, Quarles CC, Wu T, Loftus JC, Jenkins RB, Sicotte H, Kollmeyer TM, O'Neill BP, Elmquist W, Hoxworth JM, Frakes D, Sarkaria J, Swanson KR, Tran NL, Li J, Mitchell JR. Radiogenomics to characterize regional genetic heterogeneity in glioblastoma. Neuro Oncol 19(1):128-137, 2017. e-Pub 2016. PMID: 27502248.
- Wang F, Kopylov D, Zu Z, Takahashi K, Wang S, Quarles CC, Gore JC, Harris RC, Takahashi T. Mapping murine diabetic kidney disease using chemical exchange saturation transfer MRI. Magn Reson Med 76(5):1531-1541, 2016. e-Pub 2015. PMID: 26608660.
- Stokes AM, Skinner JT, Yankeelov T, Quarles CC. Assessment of a simplified spin and gradient echo (sSAGE) approach for human brain tumor perfusion imaging. Magn Reson Imaging 34(9):1248-1255, 2016. e-Pub 2016. PMID: 27457801.
- Stokes AM, Hart CP, Quarles CC. Hypoxia Imaging With PET Correlates With Antitumor Activity of the Hypoxia-Activated Prodrug Evofosfamide (TH-302) in Rodent Glioma Models. Tomography 2(3):229-237, 2016. PMID: 27752544.
- Stokes AM, Semmineh N, Quarles CC. Validation of a T1 and T2* leakage correction method based on multiecho dynamic susceptibility contrast MRI using MION as a reference standard. Magn Reson Med 76(2):613-25, 2016. e-Pub 2015. PMID: 26362714.
- Li K, Li H, Zhang XY, Stokes AM, Jiang X, Kang H, Quarles CC, Zu Z, Gochberg DF, Gore JC, Xu J. Influence of water compartmentation and heterogeneous relaxation on quantitative magnetization transfer imaging in rodent brain tumors. Magn Reson Med 76(2):635-44, 2016. e-Pub 2015. PMID: 26375875.
- Khan IS, Odom M, Ehtesham M, Colvin D, Quarles CC, McLaughlin B, Singer RJ. Intraarterial administration of norcantharidin attenuates ischemic stroke damage in rodents when given at the time of reperfusion: novel uses of endovascular capabilities. J Neurosurg 125(1):152-9, 2016. e-Pub 2015. PMID: 26544777.
- Newton AT, Pruthi S, Stokes AM, Skinner JT, Quarles CC. Improving Perfusion Measurement in DSC-MR Imaging with Multiecho Information for Arterial Input Function Determination. AJNR Am J Neuroradiol 37(7):1237-43, 2016. e-Pub 2016. PMID: 26988812.
- Abramson RG, Arlinghaus LR, Dula AN, Quarles CC, Stokes AM, Weis JA, Whisenant JG, Chekmenev EY, Zhukov I, Williams JM, Yankeelov TE. MR Imaging Biomarkers in Oncology Clinical Trials. Magn Reson Imaging Clin N Am 24(1):11-29, 2016. PMID: 26613873.
- Skinner JT, Moots PL, Ayers GD, Quarles CC. On the Use of DSC-MRI for Measuring Vascular Permeability. AJNR Am J Neuroradiol 37(1):80-7, 2016. e-Pub 2015. PMID: 26427833.
- Sorace AG, Quarles CC, Whisenant JG, Hanker AB, McIntyre JO, Sanchez VM, Yankeelov TE. Trastuzumab improves tumor perfusion and vascular delivery of cytotoxic therapy in a murine model of HER2+ breast cancer: preliminary results. Breast Cancer Res Treat 155(2):273-84, 2016. e-Pub 2016. PMID: 26791520.
- Semmineh NB, Xu J, Skinner JT, Xie J, Li H, Ayers G, Quarles CC. Assessing tumor cytoarchitecture using multiecho DSC-MRI derived measures of the transverse relaxivity at tracer equilibrium (TRATE). Magn Reson Med 74(3):772-84, 2015. e-Pub 2014. PMID: 25227668.
- Chen JK, Nagai K, Chen J, Plieth D, Hino M, Xu J, Sha F, Ikizler TA, Quarles CC, Threadgill DW, Neilson EG, Harris RC. Phosphatidylinositol 3-kinase signaling determines kidney size. J Clin Invest 125(6):2429-44, 2015. e-Pub 2015. PMID: 25985273.
- Takahashi T, Wang F, Quarles CC. Current MRI techniques for the assessment of renal disease. Curr Opin Nephrol Hypertens 24(3):217-23, 2015. PMID: 26066472.
- Stokes AM, Skinner JT, Quarles CC. Assessment of a combined spin- and gradient-echo (SAGE) DSC-MRI method for preclinical neuroimaging. Magn Reson Imaging 32(10):1181-90, 2014. e-Pub 2014. PMID: 25172987.
- Skinner JT, Robison RK, Elder CP, Newton AT, Damon BM, Quarles CC. Evaluation of a multiple spin- and gradient-echo (SAGE) EPI acquisition with SENSE acceleration: applications for perfusion imaging in and outside the brain. Magn Reson Imaging 32(10):1171-80, 2014. e-Pub 2014. PMID: 25179133.
- Wang F, Jiang R, Takahashi K, Gore J, Harris RC, Takahashi T, Quarles CC. Longitudinal assessment of mouse renal injury using high-resolution anatomic and magnetization transfer MR imaging. Magn Reson Imaging 32(9):1125-32, 2014. e-Pub 2014. PMID: 25093632.
- Yankeelov TE, Abramson RG, Quarles CC. Quantitative multimodality imaging in cancer research and therapy. Nat Rev Clin Oncol 11(11):670-80, 2014. e-Pub 2014. PMID: 25113842.
- Zu Z, Xu J, Li H, Chekmenev EY, Quarles CC, Does MD, Gore JC, Gochberg DF. Imaging amide proton transfer and nuclear overhauser enhancement using chemical exchange rotation transfer (CERT). Magn Reson Med 72(2):471-6, 2014. e-Pub 2013. PMID: 24302497.
- Wang F, Jiang RT, Tantawy MN, Borza DB, Takahashi K, Gore JC, Harris RC, Takahashi T, Quarles CC. Repeatability and sensitivity of high resolution blood volume mapping in mouse kidney disease. J Magn Reson Imaging 39(4):866-71, 2014. e-Pub 2013. PMID: 24006202.
- Mistry N, Stokes AM, Gambrell JV, Quarles CC. Nitrite induces the extravasation of iron oxide nanoparticles in hypoxic tumor tissue. NMR Biomed 27(4):425-30, 2014. e-Pub 2014. PMID: 24470164.
- Semmineh NB, Xu J, Boxerman JL, Delaney GW, Cleary PW, Gore JC, Quarles CC. An efficient computational approach to characterize DSC-MRI signals arising from three-dimensional heterogeneous tissue structures. PLoS One 9(1):e84764, 2014. e-Pub 2014. PMID: 24416281.
- Barnes SL, Quarles CC, Yankeelov TE. Modeling the effect of intra-voxel diffusion of contrast agent on the quantitative analysis of dynamic contrast enhanced magnetic resonance imaging. PLoS One 9(9):e108726, 2014. e-Pub 2014. PMID: 25275536.
- Smith DS, Li X, Abramson RG, Quarles CC, Yankeelov TE, Welch EB. Potential of compressed sensing in quantitative MR imaging of cancer. Cancer Imaging 13(4):633-44, 2013. e-Pub 2013. PMID: 24434808.
- Tantawy MN, Jiang R, Wang F, Takahashi K, Peterson TE, Zemel D, Hao CM, Fujita H, Harris RC, Quarles CC, Takahashi T. Assessment of renal function in mice with unilateral ureteral obstruction using 99mTc-MAG3 dynamic scintigraphy. BMC Nephrol 13:168, 2012. e-Pub 2012. PMID: 23228112.
- Quarles CC, Gore JC, Xu L, Yankeelov TE. Comparison of dual-echo DSC-MRI- and DCE-MRI-derived contrast agent kinetic parameters. Magn Reson Imaging 30(7):944-53, 2012. e-Pub 2012. PMID: 22617148.
- Smith DS, Li X, Gambrell JV, Arlinghaus LR, Quarles CC, Yankeelov TE, Welch EB. Robustness of quantitative compressive sensing MRI: the effect of random undersampling patterns on derived parameters for DCE- and DSC-MRI. IEEE Trans Med Imaging 31(2):504-11, 2012. e-Pub 2011. PMID: 22010146.
- Gore JC, Manning HC, Quarles CC, Waddell KW, Yankeelov TE. Magnetic resonance in the era of molecular imaging of cancer. Magn Reson Imaging 29(5):587-600, 2011. e-Pub 2011. PMID: 21524870.
- Willey CD, Xiao D, Tu T, Kim KW, Moretti L, Niermann KJ, Tawtawy MN, Quarles CC, Lu B. Enzastaurin (LY317615), a protein kinase C beta selective inhibitor, enhances antiangiogenic effect of radiation. Int J Radiat Oncol Biol Phys 77(5):1518-26, 2010. e-Pub 2009. PMID: 19906497.
- Quarles CC, Gochberg DF, Gore JC, Yankeelov TE. A theoretical framework to model DSC-MRI data acquired in the presence of contrast agent extravasation. Phys Med Biol 54(19):5749-66, 2009. e-Pub 2009. PMID: 19729712.
- Dortch RD, Yankeelov TE, Yue Z, Quarles CC, Gore JC, Does MD. Evidence of multiexponential T2 in rat glioblastoma. NMR Biomed 22(6):609-18, 2009. PMID: 19267385.
- Quarles CC, Lepage M, Gorden DL, Fingleton B, Yankeelov TE, Price RR, Matrisian LM, Gore JC, McIntyre JO. Functional colonography of Min mice using dark lumen dynamic contrast-enhanced MRI. Magn Reson Med 60(3):718-26, 2008. PMID: 18727087.
- Colvin DC, Yankeelov TE, Does MD, Yue Z, Quarles CC, Gore JC. New insights into tumor microstructure using temporal diffusion spectroscopy. Cancer Res 68(14):5941-7, 2008. PMID: 18632649.
- Lepage M, Dow WC, Melchior M, You Y, Fingleton B, Quarles CC, Pépin C, Gore JC, Matrisian LM, McIntyre JO. Noninvasive detection of matrix metalloproteinase activity in vivo using a novel magnetic resonance imaging contrast agent with a solubility switch. Mol Imaging 6(6):393-403, 2007. PMID: 18053410.
- Quarles CC, Schmainda KM. Assessment of the morphological and functional effects of the anti-angiogenic agent SU11657 on 9L gliosarcoma vasculature using dynamic susceptibility contrast MRI. Magn Reson Med 57(4):680-7, 2007. PMID: 17390352.
- Yankeelov TE, Niermann KJ, Huamani J, Kim DW, Quarles CC, Fleischer AC, Hallahan DE, Price RR, Gore JC. Correlation between estimates of tumor perfusion from microbubble contrast-enhanced sonography and dynamic contrast-enhanced magnetic resonance imaging. J Ultrasound Med 25(4):487-97, 2006. PMID: 16567438.
- Quarles CC, Krouwer HG, Rand SD, Schmainda KM. Dexamethasone normalizes brain tumor hemodynamics as indicated by dynamic susceptibility contrast MRI perfusion parameters. Technol Cancer Res Treat 4(3):245-9, 2005. PMID: 15896079.
- Quarles CC, Ward BD, Schmainda KM. Improving the reliability of obtaining tumor hemodynamic parameters in the presence of contrast agent extravasation. Magn Reson Med 53(6):1307-16, 2005. PMID: 15906288.
Abstracts
- Stokes AM, Quarles CC. A simplified spin and gradient echo approach for brain tumor perfusion imaging. Magn Reson Med 75(1):356-62, 2016. e-Pub 2015. PMID: 25753958.
Book Chapters
- Dula A, Hormuth II D, Luci J, Miga MI, Quarles CC, Sorace AG, Stokes AM, Virostko J, Weis J, Whisenant J, Yankeelov TE. Quantitative imaging using MRI. In: Radiomics and Radiogenomics. Taylor & Francis, 2018.
- Gore JC, Manning HC, Peterson TE, Quarles CC, Sinha TK, Yankeelov TE. Quantitative Biomarkers of Cancer. In: Advances in Medical Physics, 2010.
Grant & Contract Support
| Title: | One-shot morphologic, hemodynamic and metabolic MR imaging of brain tumors |
| Funding Source: | National Institutes of Health/ Arizona State University |
| Role: | Co-Principal Investigator |
| Title: | Improving Brain Tumor Delineation with Molecular PET Imaging |
| Funding Source: | Arizona Biomedical Research Consortium |
| Role: | Principal Investigator |
| Title: | A Phase II Randomized Clinical Trial of Radiotherapy Planning using conventional imaging +/- Fluciclovine Pet in Patients with Newly Diagnosed Glioblastoma |
| Funding Source: | Blue Earth Diagnostics |
| Role: | Principal Investigator |
| Title: | 18F-Fluciclovine PET imaging for distinguishing tumor progression from treatment-related effects |
| Funding Source: | Barrow Neurological Foundation |
| Role: | Co-Investigator |
| Title: | Electrical Spectral Imaging using magnetic resonance methods |
| Funding Source: | National Institutes of Health/Arizona State University |
| Role: | Co-Investigator |
| Title: | UT STARs Award |
| Funding Source: | The University of Texas System Science & Technology Acquisition and Retention (STARs) Award |
| Role: | Principal Investigator |
| Title: | Establishing the Validity of Brain Tumor Perfusion Imaging |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Multi-parametric Perfusion MRI for Therapy Response Assessment in Brain Cancer |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Relaxivity Contrast Imaging as a Biomarker of Muscle Degeneration in ALS |
| Funding Source: | NIH/NINDS |
| Role: | Principal Investigator |
| Title: | Imaging-based tumor forecasting to predict brain tumor progression and response to therapy |
| Funding Source: | NIH/NCI |
| Role: | Co-Principal Investigator |
| Title: | Recruitment of Established Investigator |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Principal Investigator |
Patient Reviews
CV information above last modified November 05, 2024