Chuandong Geng
Department of Genitourinary Medical Oncology, Division of Cancer Medicine
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Genitourinary Med Onc - Rsch, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas
Dual/Joint/Adjunct Appointment
Assistant Professor, Department of Genitourinary Med Onc - Rsch, The University of Texas MD Anderson Cancer Center, Houston, Texas
Education & Training
Degree-Granting Education
| 1999 | Shanghai Institute of Biochemistry, Shanghai, CN, Biochemistry, PhD |
| 1994 | Sichuan University, Chengdu, Sichuan PR, CN, Biochemistry, B.S |
Postgraduate Training
| 1999-2005 | Postgraduate Research Fellow, Biochemistry and Molecular Biology, LSU Health Sciences Center, New Orleans, Louisiana |
Experience & Service
Academic Appointments
Assistant Professor, Department of Cellular and Molecular Biology, Baylor College of Medicine, Houston, Texas, 2014 - 2018
Instructor, Department of Cellular and Molecular Biology, Baylor College of Medicine, Houston, Texas, 2011 - 2013
Assistant Professor of Research, Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, 2005 - 2011
Honors & Awards
| 2004 | Who's Who in Science and Engineering |
| 2003 | Who's Who in America |
Selected Publications
Peer-Reviewed Articles
- Geng, C, Zhang, MC, Manyam, GC, Vykoukal, JV, Fahrmann, JF, Peng, S, Wu, C, Park, SH, Kondraganti, S, Wang, D, Robinson, B, Loda, M, Barbieri, CE, Yap, TA, Corn, P, Hanash, S, Broom, BM, Pilie, PG, Thompson, T. SPOP Mutations Target STING1 Signaling in Prostate Cancer and Create Therapeutic Vulnerabilities to PARP Inhibitor–Induced Growth Suppression. Clinical Cancer Research 29(21):4464-4478, 2023. e-Pub 2023. PMID: 37581614.
- Tang Z, Pilie PG, Geng C, Manyam GC, Yang G, Park S, Wang D, Peng S, Wu C, Peng G, Yap TA, Corn PG, Broom BM, Thompson TC. ATR Inhibition Induces CDK1-SPOP Signaling and Enhances Anti-PD-L1 Cytotoxicity in Prostate Cancer. Clin Cancer Res 27(17):4898-4909, 2021. e-Pub 2021. PMID: 34168048.
- Wu C, Peng S, Pilie PG, Geng C, Park S, Manyam GC, Lu Y, Yang G, Tang Z, Kondraganti S, Wang D, Hudgens CW, Ledesma DA, Marques-Piubelli ML, Torres-Cabala CA, Curry JL, Troncoso P, Corn PG, Broom BM, Thompson TC. PARP and CDK4/6 Inhibitor Combination Therapy Induces Apoptosis and Suppresses Neuroendocrine Differentiation in Prostate Cancer. Mol Cancer Ther 20(9):1680-1691, 2021. e-Pub 2021. PMID: 34158347.
- Liu B, Li L, Yang G, Geng C, Luo Y, Wu W, Manyam GC, Korentzelos D, Park S, Tang Z, Wu C, Dong Z, Sigouros M, Sboner A, Beltran H, Chen Y, Corn PG, Tetzlaff MT, Troncoso P, Broom B, Thompson TC. PARP Inhibition Suppresses GR-MYCN-CDK5-RB1-E2F1 Signaling and Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer. Clin Cancer Res 25(22):6839-6851, 2019. e-Pub 2019. PMID: 31439587.
- Geng C, Kaochar S, Li M, Rajapakshe K, Fiskus W, Dong J, Foley C, Dong B, Zhang L, Kwon OJ, Shah SS, Bolaki M, Xin L, Ittmann M, O'Malley BW, Coarfa C, Mitsiades N. SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein. Oncogene 36(33):4767-4777, 2017. e-Pub 2017. PMID: 28414305.
- Coarfa C, Fiskus W, Eedunuri VK, Rajapakshe K, Foley C, Chew SA, Shah SS, Geng C, Shou J, Mohamed JS, O'Malley BW, Mitsiades N. Comprehensive proteomic profiling identifies the androgen receptor axis and other signaling pathways as targets of microRNAs suppressed in metastatic prostate cancer. Oncogene 35(18):2345-56, 2016. e-Pub 2016. PMID: 26364608.
- Eedunuri VK, Rajapakshe K, Fiskus W, Geng C, Chew SA, Foley C, Shah SS, Shou J, Mohamed JS, Coarfa C, O'Malley BW, Mitsiades N. miR-137 Targets p160 Steroid Receptor Coactivators SRC1, SRC2, and SRC3 and Inhibits Cell Proliferation. Mol Endocrinol 29(8):1170-83, 2015. e-Pub 2015. PMID: 26066330.
- He B, Lanz RB, Fiskus W, Geng C, Yi P, Hartig SM, Rajapakshe K, Shou J, Wei L, Shah SS, Foley C, Chew SA, Eedunuri VK, Bedoya DJ, Feng Q, Minami T, Mitsiades CS, Frolov A, Weigel NL, Hilsenbeck SG, Rosen DG, Palzkill T, Ittmann MM, Song Y, Coarfa C, O'Malley BW, Mitsiades N. GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex. Proc Natl Acad Sci U S A 111(51):18261-6, 2014. e-Pub 2014. PMID: 25489091.
- Geng C, Rajapakshe K, Shah SS, Shou J, Eedunuri VK, Foley C, Fiskus W, Rajendran M, Chew SA, Zimmermann M, Bond R, He B, Coarfa C, Mitsiades N. Androgen receptor is the key transcriptional mediator of the tumor suppressor SPOP in prostate cancer. Cancer Res 74(19):5631-43, 2014. e-Pub 2014. PMID: 25274033.
- Miller AL, Geng C, Golovko G, Sharma M, Schwartz JR, Yan J, Sowers L, Widger WR, Fofanov Y, Vedeckis WV, Thompson EB. Epigenetic alteration by DNA-demethylating treatment restores apoptotic response to glucocorticoids in dexamethasone-resistant human malignant lymphoid cells. Cancer Cell Int 14:35, 2014. e-Pub 2014. PMID: 24795534.
- Geng C, He B, Xu L, Barbieri CE, Eedunuri VK, Chew SA, Zimmermann M, Bond R, Shou J, Li C, Blattner M, Lonard DM, Demichelis F, Coarfa C, Rubin MA, Zhou P, O'Malley BW, Mitsiades N. Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover. Proc Natl Acad Sci U S A 110(17):6997-7002, 2013. e-Pub 2013. PMID: 23559371.
- Sarvaiya PJ, Schwartz JR, Geng CD, Vedeckis WV. c-Myb interacts with the glucocorticoid receptor and regulates its level in pre-B-acute lymphoblastic leukemia cells. Mol Cell Endocrinol 361(1-2):124-32, 2012. e-Pub 2012. PMID: 22516378.
- Geng CD, Vedeckis WV. A new, lineage specific, autoup-regulation mechanism for human glucocorticoid receptor gene expression in 697 pre-B-acute lymphoblastic leukemia cells. Mol Endocrinol 25(1):44-57, 2011. e-Pub 2011. PMID: 21084380.
- Geng CD, Vedeckis WV. Use of recombinant cell-permeable small peptides to modulate glucocorticoid sensitivity of acute lymphoblastic leukemia cells. Biochemistry 49(41):8892-901, 2010. e-Pub 2010. PMID: 20831260.
- Geng CD, Schwartz JR, Vedeckis WV. A conserved molecular mechanism is responsible for the auto-up-regulation of glucocorticoid receptor gene promoters. Mol Endocrinol 22(12):2624-42, 2008. e-Pub 2008. PMID: 18945813.
- Geng CD, Vedeckis WV. c-Myb and members of the c-Ets family of transcription factors act as molecular switches to mediate opposite steroid regulation of the human glucocorticoid receptor 1A promoter. J Biol Chem 280(52):43264-71, 2005. e-Pub 2005. PMID: 16263717.
- Geng CD, Pedersen KB, Nunez BS, Vedeckis WV. Human glucocorticoid receptor alpha transcript splice variants with exon 2 deletions: evidence for tissue- and cell type-specific functions. Biochemistry 44(20):7395-405, 2005. e-Pub 2005. PMID: 15895983.
- Nunez BS, Geng CD, Pedersen KB, Millro-Macklin CD, Vedeckis WV. Interaction between the interferon signaling pathway and the human glucocorticoid receptor gene 1A promoter. Endocrinology 146(3):1449-57, 2005. e-Pub 2005. PMID: 15576464.
- Pedersen KB, Geng CD, Vedeckis WV. Three mechanisms are involved in glucocorticoid receptor autoregulation in a human T-lymphoblast cell line. Biochemistry 43(34):10851-8, 2004. e-Pub 2004. PMID: 15323545.
- Garg R, Geng CD, Miller JL, Callens S, Tang X, Appel B, Xu B. Molecular cloning and characterization of the catalytic domain of zebrafish homologue of the ataxia-telangiectasia mutated gene. Mol Cancer Res 2(6):348-53, 2004. e-Pub 2004. PMID: 15235110.
- Geng CD, Vedeckis WV. Steroid-responsive sequences in the human glucocorticoid receptor gene 1A promoter. Mol Endocrinol 18(4):912-24, 2004. e-Pub 2004. PMID: 15044598.
- Breslin MB, Geng CD, Vedeckis WV. Multiple promoters exist in the human GR gene, one of which is activated by glucocorticoids. Mol Endocrinol 15(8):1381-95, 2001. e-Pub 2001. PMID: 11463861.
- Hao JJ, Geng C, Xie W, Gong Z, Liu WY, Wang E. Isolation and characterization of viridin, a new 65 kDa antifungal protein from the mould Trichoderma viride. Biol Chem 380(10):1243-5, 1999. e-Pub 1999. PMID: 10595589.
- Hao JJ, Xu Yz, Geng CD, Liu WY, Wang Ed, Gong ZZ, Ulbrich N. Purification of alpha-sarcin and an antifungal protein from Aspergillus giganteus by blue sepharose CL-6B affinity chromatography. Protein Expr Purif 14(2):295-301, 1998. e-Pub 1998. PMID: 9790894.
Other Articles
- Geng C, Rajapakshe K, Shah SS, Shou J, Eedunuri VK, Foley C, Fiskus W, Rajendran M, Chew SA, Zimmermann M, Bond R, He B, Coarfa C, Mitsiades N Correction: Androgen Receptor Is the Key Transcriptional Mediator of the Tumor Suppressor SPOP in Prostate Cancer. Cancer Res 79(17):4552, 2019. PMID: 31481421.
Letters to the Editor
- Geng, C, Thompson, T. DNA Damage Response Inhibitor and Anti-PD-L1 Therapy for Prostate Cancer. Engineering 12: 12-15, 2022.
Selected Presentations & Talks
Local Presentations
- 2005. Regulation of Glucocorticoid receptor gene expression in Acute Lymphoblastic Leukemia. Invited. Department of Biochemistry and Molecular Biology Seminar. New Orleans, Louisiana, US.
Regional Presentations
- 2010. Lineage Specific Auto-regulatory Expression of human Glucocorticoid Receptor in Early Pre-B Cell Acute Lymphoblastic Leukemia. Invited. LCRC Retreat. New Orleans, Louisiana, US.
- 2009. Use of Cell Permeable Peptides to Modulate Apoptosis Sensitivity of Acute Lymphoblastic Leukemia Cells to Glucocorticoids. Invited. LCRC Retreat. New Orleans, Louisiana, US.
National Presentations
- 2016. Nuclear Receptors and Cancer Treatment. Invited, US.
- 2013. Glucocorticoid-responsive sequences in the Bim gene promoter and the role of c-Myb in Bim promoter expression. Invited. Department of Biology Seminar, US.
- 2010. Regulation of Glucocorticoid Induced Apoptosis in Acute Lymphoblastic Leukemia. Invited. Department of Biology Seminar, US.
- 2009. Use of Cell Permeable Peptides to Modulate Intracellular Expression of the Glucocorticoid Receptor in Acute Lymphoblastic Leukemia Cells. Conference, US.
- 2008. Auto-Regulation of Human Glucocorticoid Receptor Gene Promoters in B-Cell Acute Lymphoblastic Leukemia. Conference, US.
- 2005. A Molecular Switch is Involved in the Opposite Autoregulation of the Human Glucocorticoid Receptor 1A Promoter in Lymphoblast Cells. Invited. San Diego, California, US.
- 2004. The c-Myb Protein and c-Ets Protein Family Members Modulate Human Glucocorticoid Receptor 1A Promoter Autoregulation in Lymphoblastic Cells. Conference, US.
- 2003. Identification of Functional, Alternatively Spliced, Human Glucocorticoid Receptor Transcripts with Exon 2 Deletions in Human T-Lymphoblastic Leukemia Cells. Conference, US.
- 2002. GC Response Elements Mediating Upregulation of hGR 1A Promoter Expression in T-cells. Conference, US.
- 2001. Multiple DNA Regulatory Elements Control Human Glucocorticoid Receptor 1A Promoter Activity. Conference, US.
- 2001. Interferons Stimulate the Novel Glucocorticoid Receptor 1A Promoter/Exon Gene. Conference, US.
Patient Reviews
CV information above last modified March 11, 2025