Chun Li, Ph.D.

Peer-Reviewed Articles

1. Liu Y, Ahumada AL, Bayraktar E, Schwartz P, Chowdhury M, Shi S, Sebastian MM, Khant H, de Val N, Bayram NN, Zhang G, Vu TC, Jie Z, Jennings NB, Rodriguez-Aguayo C, Swain J, Stur E, Mangala LS, Wu Y, Nagaraju S, Ermias B, Li C, Lopez-Berestein G, Braam J, Sood AK. Enhancing oral delivery of plant-derived vesicles for colitis. J. Control. Release 357:472-483, 2023. e-Pub 2023. PMID: 37031740.
2. Long X, Dai AN, Huang T, Niu WH, Liu LX, Xu H, Yin T, Jiang TA, Sun SG, Lei P, C* L, XH* Z, J* Z. Simultaneous delivery of dual inhibitors of DNA damage repair sensitizes pancreatic cancer response to irreversible electroporation. ACS Nano 17(13):12915-12932, 2023. e-Pub 2023.
3. Cook S, Wittenburg L, Yan VC, Theil JH, Castillo D, Reagan KL, Williams S, Pham CD, Li C, Muller FL, Murphy BG. An optimized bioassay for screening combined anticoronaviral compounds for efficacy against feline infectious peritonitis virus with pharmacokinetic analyses of GS-441524, Remdesivir, and molnupiravir in cats. Viruses 14(11):2429, 2022. e-Pub 2022. PMID: 36366527.
4. Lu Y, Li C. Incidental findings of coexisting metastatic pancreatic cancer in patients with prostate cancer on 18F-prostate-specific membrane antigen PET/CT. Clin Nucl Med 47(12):1103-1104. e-Pub 2022. PMID: 35835124.
5. Peng H, Shen J, Long X, Zhou X, Zhang J, Xu X, Huang T, Xu H, Sun S, Li C, Lei P, Wu H, Zhao J. Local release of TGF-β inhibitor modulates tumor-associated neutrophils and enhances pancreatic cancer response to combined irreversible electroporation and immunotherapy. Adv Sci published by Wiley-VCH GmbH 9(10):e2105240, 2022. e-Pub 2022. PMID: 35128843.
6. Lincha VR, Zhao J, Wen X, Xiong C, Chow DSL, Li C. A polymeric micellar drug delivery system developed through a Design of Experiment approach improves pancreatic tumor accumulation of calcipotriol and paclitaxel. Int J Pharm 601:120523 (1-10), 2021. e-Pub 2021. PMID: 33775721.
7. Huang YQ, Yang Z, Li F, Zhao H, Li C, Yu N, Hamilton D, Li Z. 64Cu/177Lu-DOTA-diZD, a small molecule-based theranostic pair for triple-negative breast cancer. Journal of Medicinal Chemistry 64(5):2705-2713, 2021. e-Pub 2021. PMID: 33646782.
8. Cao QZ, Huang Q, Wang YA, Li C. Abraxane-induced bone marrow CD11b+ myeloid cell depletion in tumor-bearing mice is visualized by μPET-CT with 64Cu-labeled anti-CD11b and prevented by anti-CSF-1. Theranostics 11(7):3527-3539, 2021. e-Pub 2021. PMID: 33537102.
9. Lincha LR, C-H H, Zhao J, Li C, S-L CD. Sensitive and rapid UHPLC-MS/MS assay for simultaneous quantifications of calcipotriol and paclitaxel in rat whole blood and plasma samples. J Pharm Biomed Anal 192:113685, 2020. e-Pub 2020. PMID: 33099115.
10. Sheth RA, Wen X, Li J, Melancon MP, Ji X, Wang YA, Hsiao C-H H, DS-L C, Whitley EM, Li C, Gupta S. Doxorubicin-loaded hollow gold nanospheres for dual photothermal ablation and chemoembolization therapy. Cancer Nanotechnology 11(1):6 (page 1-16), 2020. e-Pub 2020. PMID: 34335988.
11. Cao QZ, Wang WQ, Zhou M, Huang Q, Wen XX, Zhao J, Shi SX, Geng K, Li FE, Hatakeyama H, Xu CY, Piwnica-Worms D, Peng WY, Zhou DP, Sood AK, Li C. Induction of anti-tumor immunity in mice by the combination of nanoparticle-based photothermolysis and anti-PD-1 checkpoint inhibition. Nanomedicine 25:102169 (page 1-12), 2020. e-Pub 2020. PMID: 32059873.
12. Liu F, Guo X, Liu T, Xu X, Li N, Xiong C, Li C, Zhu H, Yang Z. Evaluation of pan-SSTRs targeted radioligand [64Cu]NOTA-PA1 using micro-PET imaging in xenografted mice. ACS Med Chem Lett 11(4):445-450, 2020. e-Pub 2020. PMID: 32292548.
13. Xiong CY, Wen YF, Zhao J, Yin DK, Xu LY, Chelariu-Raicu A, Yao C, Leng XH, Liu JS, Chaudhari RR, Zhang SX, Sood AK, Li C. Targeting forward and reverse EphB4/EFNB2 signaling by a peptide with dual functions. Scientific Reports 10(1):520, 2020. e-Pub 2020. PMID: 31949258.
14. Zhao J, Wen XX, Li TT, Shi SX, Wang YA, Li C. Concurrent injection of unlabeled antibodies allows positron emission tomography imaging of programmed cell death ligand 1 expression in an orthotopic pancreatic tumor model. ACS Omega 5(15):8474-8482, 2020. e-Pub 2020. PMID: 32337408.
15. Shi SX, Li TT, Wen XF, Wu S, Xiong CY, Zhao J, Lincha VR, S-L CD, Liu YY, Sood AK, Li C. Copper-64 labeled PEGylated exosomes for in vivo positron emission tomography and enhanced tumor retention. Bioconjugate Chemistry 30(10):2675-2683, 2019. e-Pub 2019. PMID: 31560538.
16. Shi SX, Wen XF, Li TT, Wen XX, Cao QZ, Liu XL, Liu YY, Pagel MD, Li C. Thermosensitive biodegradable copper sulfide nanoparticles for real-time multispectral optoacoustic tomography. ACS Appl Bio Mater 2(8):3203-3211, 2019. e-Pub 2019. PMID: 33907729.
17. Xiong C, Yin D, Li J, Huang Q, Ravoori MK, Kundra V, Zhu H, Yang Z, Lu Y, Li C. Metformin reduces renal uptake of radiotracers and protects kidneys from radiation-induced damage. Mol Pharm 16(2):808-15, 2019. e-Pub 2019. PMID: 30608713.
18. Zhao J, Wen XF, Tian L, Li TT, Xu CY, Wen XX, Melancon MP, Gupta S, Shen BZ, Peng WY, Li C. Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer. Nature Commun 10(1):article number: 899 (p1-14), 2019. e-Pub 2019. PMID: 30796212.
19. C-H H, Zhao J, Gao S, Farhan N, Wang Y, Li C, S-L CD. Development and validation of a rapid and sensitive UPLC MS/MS assay for simultaneous quantification of paclitaxel and cyclopamine in mouse whole blood and tissue samples. Biomed Chromatogr 33(9):e4518, 2019. e-Pub 2019. PMID: 30805953.
20. Cao QZ, Huang Q, Mohan C, Li C. μPET/CT imaging of local and systemic immune response using 64Cu-αCD11b. J Nucl Med 60(9):1317-1324, 2019. e-Pub 2019. PMID: 30796172.
21. Cui L, Xiong C, Zhou M, Shi S, Chow DS, Li C. Integrin αγβ3-targeted [64Cu]CuS nanoparticles for PET/CT imaging and photothermal ablation therapy. Bioconjug Chem 29(12):4062–71, 2018. e-Pub 2018. PMID: 30404438.
22. Ku G, Huang Q, Wen X, Ye J, Piwnica-Worms D, Li C. Spatial and temporal confined photothermolysis of cancer cells mediated by hollow gold nanospheres targeted to epidermal growth factor receptors. ACS Omega 3(5):5888-5895, 2018. e-Pub 2018. PMID: 29876540.
23. Zhao J, Wang H, Hsiao CH, Chow DS, Koay EJ, Kang Y, Wen X, Huang Q, Ma Y, Bankson JA, Ullrich SE, Overwijk W, Maitra A, Piwnica-Worms D, Fleming JB, Li C. Simultaneous inhibition of hedgehog signaling and tumor proliferation remodels stroma and enhances pancreatic cancer therapy. Biomaterials 159:215-228, 2018. e-Pub 2018. PMID: 29331808.
24. Liu F, Liu T, Xu X, Guo X, Li N, Xiong C, Li C, Zhu H, Yang Z. Design, synthesis, and biological evaluation of 68Ga-DOTA-PA1 for lung cancer: A novel PET tracer for multiple somatostatin receptor imaging. Mol Pharm 15(2):619-628, 2018. e-Pub 2018. PMID: 29278911.
25. Cao Q, Yan X, Chen K, Huang Q, Melancon MP, Lopez G, Cheng Z, Li C. Macrophages as a potential tumor-microenvironment target for noninvasive imaging of early response to anticancer therapy. Biomaterials 152:63-76, 2018. e-Pub 2018. PMID: 29111494.
26. Xiong C, Lu W, Zhou M, Wen X, Li C. Cisplatin-loaded hollow gold nanoparticles for laser-triggered release. Cancer Nanotechnol 9(1):6 (1-13), 2018. e-Pub 2018. PMID: 30147806.
27. Jun Z, Xiao ZL, Li TT, Chen HQ, Yuan Y, Wang YA, Hsiao CH, Chow DSL, Overwijk WW, Li C. Stromal modulation reverses primary resistance to immune checkpoint blockade in pancreatic cancer. ACS Nano 12(10):9881–9893, 2018. e-Pub 2018. PMID: 30231203.
28. Chen G, Ma B, Wang Y, Xie R, Li C, Dou K, Gong S. CuS-based theranostic micelles for NIR-controlled combination chemotherapy and photothermal therapy, and photoacoustic imaging. ACS Appl Mater Interfaces 9(48):41700-41711, 2017. e-Pub 2017. PMID: 29154532.
29. Li Y, Singh N, Yan J, Chen DH, Zhou M, Mittelstaedt RA, Chen Y, Li C, Doak SH, Chen T. Factors affecting the in vitro micronucleus assay for evaluation of nanomaterials. Mutagenesis 32(1):151-59, 2017. e-Pub 2017. PMID: 27567283.
30. Ma Q, Zhou D, DeLyria ES, Wen X, Lu W, Thapa P, Liu C, Li D, Bassett RL, Overwijk WW, Hwu P, Li C. Synthetic poly(L-glutamic acid)-conjugated CpG exhibits antitumor efficacy with increased retention in tumor and draining lymph nodes after intratumoral injection in a mouse model of melanoma. J Immunother 40(1):11-20, 2017. e-Pub 2017. PMID: 27681378.
31. Wang W, Zhao J, Wen X, Lin CC, Li J, Huang Q, Yu Y, Lin SY, Li C. MicroPET/CT imaging of AXL downregulation by HSP90 inhibition in triple-negative breast cancer. Contrast Media Mol Imaging 2017:1686525, 2017. e-Pub 2017. PMID: 29097911.
32. Li J, Zhou M, Liu F, Xiong C, Wang W, Cao Q, Wen X, Robertson JD, Ji X, Wang YA, Gupta S, Li C. Hepatocellular carcinoma: Intra-arterial delivery of doxorubicin-loaded hollow gold nanospheres for photothermal ablation-chemoembolization therapy in rats. Radiology 281(2):427-435, 2016. e-Pub 2016. PMID: 27347765.
33. Hatakeyama H, Wu SY, Lyons YA, Pradeep S, Wang W, Huang Q, Court KA, Liu T, Nie S, Rodriguez-Aguayo C, Shen F, Huang Y, Hisamatsu T, Mitamura T, Jennings N, Shim J, Dorniak PL, Mangala LS, Petrillo M, Petyuk VA, Schepmoes AA, Shukla AK, Torres-Lugo M, Lee JS, Rodland KD, Fagotti A, Lopez-Berestein G, Li C, Sood AK. Role of CTGF in sensitivity to hyperthermia in ovarian and uterine cancers. Cell Reports 17(6):1621-31, 2016. e-Pub 2016. PMID: 27806300.
34. Belousova N, Mikheeva G, C-Y X, Stagg LJ, Gagea M, Fox PS, Bassett R, Ladbury JE, Braun MB, Stehle T, Li C, Krasnykh V. Native and engineered tropism of vectors derived from a rare species D adenovirus serotype 43. Oncotarget 7(33):53414-53429, 2016. e-Pub 2016. PMID: 27462785.
35. Liu F, Zhu H, Lin XF, Xiong CY, Li C, Yang Z. Design and radio-synthesis of somatostatin receptors targeted 68Ga-DOTA-Benereotide for non-invasive PET imaging. J Radio Nucl Chem 307:1069-75, 2016. e-Pub 2016.
36. Tam AL, Melancon MP, Abdelsalam M, Figueira TA, Dixon K, McWatters A, Zhou M, Huang Q, Mawlawi O, Dunner K, Li C, Gupta S. Imaging intratumoral nanoparticle uptake after combining nanoembolization with various ablative therapies in hepatic VX2 rabbit tumors. J Biomed Nanotech 12(2):296-307, 2016. e-Pub 2016. PMID: 27305763.
37. Zhou M, Melancon M, Stafford RJ, Li J, Nick AM, Tian M, Sood AK, Li C. Precision nanomedicine using dual positron emission tomography and magnetic resonance temperature imaging-guided photothermal therapy. J Nucl Med 57(11):1778-83, 2016. e-Pub 2016. PMID: 27283932.
38. Liu Q, Zhou M, Li P, Ku G, Huang G, Li C, Song S. (64) CuS-labeled nanoparticles: a new sentinel-lymph-node-mapping agent for PET-CT and photoacoustic tomography. Contrast Media Mol Imaging 11(6):475-81, 2016. e-Pub 2016. PMID: 27523742.
39. Zhou M, Song, SL, Zhao J, Tian M, Li C. Theranostic CuS nanoparticles targeting folate receptors for PET image-guided photothermal therapy (Cover Illustration). J Mater Chem B 3(46):8939-48, 2015. e-Pub 2015. PMID: 27725882.
40. Pradeep S, Huang J, Mora EM, Nick AM, Cho MS, Wu SY, Noh K, Pecot CV, Rupaimoole R, Stein MA, Brock S, Wen Y, Xiong C, Gharpure K, Hansen JM, Nagaraja AS, Previs RA, Vivas-Mejia P, Han HD, Hu W, Mangala LS, Zand B, Stagg LJ, Ladbury JE, Ozpolat B, Alpay SN, Nishimura M, Stone RL, Matsuo K, Armaiz-Peña GN, Dalton HJ, Danes C, Goodman B, Rodriguez-Aguayo C, Kruger C, Schneider A, Haghpeykar S, Jaladurgam P, Hung MC, Coleman RL, Liu J, Li C, Urbauer D, Lopez-Berestein G, Jackson DB, Sood AK. Erythropoietin stimulates tumor growth via EphB4. Cancer Cell 28(5):610-22, 2015. e-Pub 2015. PMID: 26481148.
41. Zhao J, Qiao Y, Zhou M, Wallace M, Gupta S, C* L, MP* M. Antitumor efficacy study using irreversible electroporation and doxorubicin-loaded polymeric micelles. ACS Macro Lett 4(10):1081-84, 2015. e-Pub 2015. PMID: 28529822.
42. Zhou M, Chen Y, Adachi M, Wen X, Erwin B, Mawlawi O, Lai SY, Li C. Single agent nanoparticle for radiotherapy and radio-photothermal therapy in anaplastic thyroid cancer. Biomaterials 57:41-9, 2015. e-Pub 2015. PMID: 25913249.
43. DeLyria ES, Zhou D, Lee JS, Singh S, Song W, Li F, Sun Q, Lu H, Wu J, Qiao Q, Hu Y, Zhang G, Li C, Sastry KJ, Shen H. Sublingual injection of microparticles containing glycolipid ligands for NKT cells and subunit vaccines induces antibody responses in oral cavity. Carbohydr Res 405:87-92, 2015. e-Pub 2015. PMID: 25555750.
44. Zhao J, Wu C, Abbruzzese J, Hwang RF, Li C. Cyclopamine-loaded core-crosslinked polymeric micelles enhance radiation response in pancreatic cancer and pancreatic stellate cells. Mol Pharm 12(6):2093-100, 2015. e-Pub 2015. PMID: 25936695.
45. You J, Zhao J, Wen X, Wu C, Huang Q, Guan F, Wu R, Liang D, Li C. Chemoradiation therapy using cyclopamine-loaded liquid-lipid nanoparticles and lutetium-177-labeled core-crosslinked polymeric micelles. J Controlled Release 202:40-8, 2015. e-Pub 2015. PMID: 25637565.
46. Zhou M, Li J, Liang S, Sood AK, Liang D, Li C. CuS nanodots with ultrahigh efficient renal clearance for positron emission tomography imaging and image-guided photothermal therapy. ACS Nano 9(7):7085-96, 2015. e-Pub 2015. PMID: 26098195.
47. Zhou M, Zhao J, Tian M, Song S, Zhang R, Gupta S, Tan D, Shen H, Ferrari M, Li C. Radio-photothermal therapy mediated by a single compartment nanoplatform depletes tumor initiating cells and reduces lung metastasis in the orthotopic 4T1 breast tumor model (Cover Illustration). Nanoscale 7(46):19438-47, 2015. e-Pub 2015. PMID: 26376843.
48. Zhou M, Ku G, Pageon L, Li C. Theranostic probe for simultaneous in vivo photoacoustic imaging and confined photothermolysis by pulsed laser at 1064 nm in 4T1 breast cancer model. Nanoscale 6(24):15228-35, 2014. e-Pub 2014. PMID: 25379880.
49. Hong Y, Zhu H, Hu J, Lin XF, Wang F, Li C, Yang Z. Synthesis and radiolabeling of 111In-core-cross linked polymeric micelle-octreotide for near-infrared fluoroscopy and single photon emission computed tomography imaging. Bioorg Med Chem Lett 24(12):2781-5, 2014. e-Pub 2014. PMID: 24815512.
50. Melancon MP, Zhou M, Zhang R, Xiong C, Allen P, Wen X, Huang Q, Wallace M, Myers JN, Stafford RJ, Liang D, Ellington AD, Li C. Selective uptake and imaging of aptamer- and antibody-conjugated hollow nanospheres targeted to epidermal growth factor receptors overexpressed in head and neck cancer. ACS Nano 8(5):4530-8, 2014. e-Pub 2014. PMID: 24754567.
51. You J, Zhou J, Zhou M, Liu Y, Robertson JD, Liang D, Van Pelt C, Li C. Pharmacokinetics, clearance, and biosafety of polyethylene glycol-coated hollow gold nanospheres. Part Fibre Toxicol 11(26):1-17, 2014. e-Pub 2014. PMID: 24886070.
52. You J, Zhang P, Hu F, Du Y, Yuan H, Zhu J, Wang Z, Zhou J, Li C. Near-infrared light sensitive liposomes for the enhanced photothermal tumor treatment by the combination with chemotherapy. Pharm Res 31(3):554-65, 2014. e-Pub 2014. PMID: 24022681.
53. Huang M, Xiong C, Lu W, Zhang R, Zhou M, Huang Q, Weinberg J, Li C. Dual-modality micro-positron emission tomography/computed tomography and near-infrared fluorescence imaging of EphB4 in orthotopic glioblastoma xenograft models. Mol Imaging Biol 16(1):74-84, 2014. e-Pub 2014. PMID: 23918654.
54. Lee HJ, Liu Y, Zhao J, Zhou M, Bouchard RR, Mitcham T, Wallace M, Stafford RJ, Li C, Gupta S, Melancon MP. In vitro and in vivo mapping of drug release after laser ablation thermal therapy with doxorubicin-loaded hollow gold nanoshells using fluorescence and photoacoustic imaging. J Controlled Rel 172(1):152-8, 2013. e-Pub 2013. PMID: 23920038.
55. Zhao N, You J, Zeng Z, C* L, Y* Z. An ultra pH-sensitive and aptamer-equipped nanoscale drug-delivery system for selective killing of tumor cells. Small 9(20):3477-84, 2013. e-Pub 2013. PMID: 23609964.
56. Tian M, Lu W, Zhang R, Xiong C, Ensor J, Nazario J, Jackson J, Shaw C, Dixon KA, Miller J, Wright K, Li C, Gupta S. Tumor uptake of hollow gold nanospheres after intravenous and transcatheter arterial injection: A PET/CT study in a rabbit VX2 liver cancer model. Mol Imaging Biol 15(5):614-24, 2013. e-Pub 2013. PMID: 23608932.
57. You J, Wang ZH, Du YZ, Yuan H, Zhang PZ, Zhou JL, Liu F, Li C, Hu FQ. Specific tumor delivery of paclitaxel using glycolipid-like polymer micelles containing gold nanospheres. Biomaterials 34(18):4510-19, 2013. e-Pub 2013. PMID: 23510855.
58. Zhang R, Huang M, Zhou M, Wen X, Huang Q, Li C. Annexin A5-functionalized nanoparticle for multimodal imaging of cell death. Mol Imaging 12(3):182-190, 2013. e-Pub 2013. PMID: 23490444.
59. Zhu H, Zhao J, Lin X, Hong Y, Li C, Yang Z. Design, synthesis and evaluation of dual-modality glyco-nanoparticles for tumor imaging. Molecules 18(6):6425-38, 2013. e-Pub 2013. PMID: 23722731.
60. Song SL, Xiong CY, Lu W, Ku G, Huang G, Li C. Apoptosis imaging probe predicts early chemotherapy response in preclinical models: a comparative study with 18F-FDG PET. J Nucl Med 54(1):104-10, 2013. e-Pub 2013. PMID: 23283564.
61. Cao Y, Marks JD, Huang Q, Rudnick SI, Xiong CY, Hittelman WN, Wen XX, Marks JW, Cheung LH, Boland K, Adams GP, Li C, Rosenblum MG. Single-chain antibody-based immunotoxins targeting Her2/neu: design optimization and impact of affinity on antitumor efficacy and off-target toxicity. Mol Cancer Ther 11(1):143-153, 2012. e-Pub 2012. PMID: 22090420.
62. Yang Z, Xiong C, Zhang R, Zhu H, Li C. Synthesis and evaluation of (68)Ga-labeled DOTA-2-deoxy-D-glucosamine as a potential radiotracer in μPET imaging. Am J Nucl Med Mol Imaging 2(4):499-507, 2012. e-Pub 2012. PMID: 23145365.
63. Zhang G, Zhang R, Melancon MP, Wong K, You J, Huang Q, Bankson J, Liang D, Li C. The degradation and clearance of poly(N-hydroxypropyl-L-glutamine)-DTPA-Gd as a blood pool MRI contrast agent. Biomaterials 33(21):5376-5383, 2012. e-Pub 2012. PMID: 22541356.
64. Zhao J, Song S, Zhong M, Li C. Dual-modal tumor imaging via long-circulating biodegradable core-crosslinked polymeric micelles. ACS Macro Lett 1(1):150-153, 2012. e-Pub 2012. PMID: 22685693.
65. You J, Zhang R, G-D Z, Zhong M, Liu Y, Van Pelt CS, Liang D, Wei W, Sood AK, Li C. Photothermal-chemotherapy with doxorubicin-loaded hollow gold nanospheres: A platform for near-infrared light-trigged drug release. J Controlled Rel 158(2):319-328, 2012. e-Pub 2012. PMID: 22063003.
66. Gupta S, Stafford RJ, Javedi S, Ozkan E, Ensor J, Wright K, Elliot A, Jian Y, Serda R, Wallace M, Li C. Effects of near-infrared laser irradiation of biodegradable microspheres containing hollow gold nanospheres and paclitaxel administered intra-arterially in a rabbit liver tumor model. J Vas Interv Radiol 23(4):553-561, 2012. e-Pub 2012. PMID: 22341633.
67. Shen HF, You J, Zhang GD, Ziemys A, Li QP, Bai LT, Deng XY, Erm DR, Liu XW, Li C, Ferrari M. Cooperative, nanoparticle-enabled thermal therapy of breast cancer (Cover Illustration). Adv Healthcare Mat 1(1):84-89, 2012. e-Pub 2012. PMID: 23184690.
68. Lu W, Xiong C, Zhang R, Shi L, Huang M, Zhang G, Song S, Huang Q, Liu GY, Li C. Receptor-mediated transcytosis: a mechanism for active extravascular transport of nanoparticles in solid tumors (Cover Illustration). J Controlled Rel 161(3):959-966, 2012. e-Pub 2012. PMID: 22617522.
69. Ku G, Zhou M, Song S, Huang Q, Hazle J, Li C. Copper sulfide nanoparticles as a new class of photoacoustic contrast agent for deep tissue imaging at 1064 nm. ACS Nano 6(8):7489-96, 2012. e-Pub 2012. PMID: 22812694.
70. You J, Zhang R, Xiong C, Zhong M, Melancon M, Gupta S, Nick AM, Sood AK, Li C. Effective photothermal chemotherapy using doxorubicin-loaded gold nanospheres that target EphB4 receptors in tumors (Cover Illustration). Cancer Res 72(18):4777-86, 2012. e-Pub 2012. PMID: 22865457.
71. Zhang R, Xiong C, Huang M, Zhou M, Huang Q, Wen X, Liang D, Li C. Peptide-conjugated polymeric micellar nanoparticles for dual SPECT and optical imaging of EphB4 receptors in prostate cancer xenografts. Biomaterials 32(25):5872-9, 2011. e-Pub 2011. PMID: 21612822.
72. Xiong C, Brewer K, Song S, Zhang R, Lu W, Wen X, Li C. Peptide-based imaging agents targeting phosphatidylserine for the detection of apoptosis. J Med Chem 54(6):1825-35, 2011. e-Pub 2011. PMID: 21348464.
73. Xiong C, Huang M, Zhang R, Song S, Lu W, Flores L, Gelovani J, Li C. In vivo small-animal PET/CT of EphB4 receptors using 64Cu-labeled peptide. J Nucl Med 52(2):241-8, 2011. e-Pub 2011. PMID: 21233177.
74. Perin EC, Tian M, Marini III FC, Silva GV, Zheng Y, Baimbridge F, Quan X, Fernandes MR, Gahremanpour A, Young D, Paolillo V, Mukhopadhyay U, Borne AT, Uthamanthil R, Brammer D, Jackson J, Decker WK, Najjar AM, Thomas MW, Volgin A, Rabinovich B, Soghomonyan S, Jeong HJ, Rios JM, Steiner D, Robinson S, Mawlawi O, Pan T, Stafford J, Kundra V, Li C, Alauddin MM, Shpall E, Gelovani JG. Imaging long-term fate of intramyocardially implanted mesenchymal stem cells in a porcine myocardial infarction model. PLoS One 6(9):e22949, 2011. e-Pub 2011. PMID: 21912635.
75. Zhang R, Lu W, Wen X, Huang M, Zhou M, Liang D, Li C. Annexin A5-conjugated polymeric micelles for dual SPECT and optical detection of apoptosis. J Nucl Med 52(6):958-64, 2011. e-Pub 2011. PMID: 21571801.
76. Wen X, Lyu MA, Zhang R, Lu W, Huang Q, Liang D, Rosenblum MG, Li C. Biodistribution, pharmacokinetics, and nuclear imaging studies of (111)In-labeled rGel/BLyS fusion toxin in SCID mice bearing B cell lymphoma. Mol Imaging Biol 13(4):721-9, 2011. e-Pub 2011. PMID: 20686856.
77. Melancon MP, Elliott A, Ji X, Shetty A, Yang Z, Tian M, Taylor B, Stafford RJ, Li C. Theranostics with multifunctional magnetic gold nanoshells: photothermal therapy and T2* magnetic resonance imaging. Invest Radiol 46(2):132-40, 2011. e-Pub 2011. PMID: 21150791.
78. Song S, Xiong C, Zhou M, Lu W, Huang Q, Ku G, Zhao J, Flores LG, Ni Y, Li C. Small-animal PET of tumor damage induced by photothermal ablation with 64Cu-Bis-DOTA-hypericin. J Nucl Med 52(5):792-9, 2011. e-Pub 2011. PMID: 21498539.
79. Melancon MP, Lu W, Zhong M, Zhou M, Liang G, Elliott AM, Hazle JD, Myers JN, Li C, Stafford RJ. Targeted multifunctional gold-based nanoshells for magnetic resonance-guided laser ablation of head and neck cancer. Biomaterials 32(30):7600-8, 2011. e-Pub 2011. PMID: 21745689.
80. Melancon MP, Lu W, Zhong M, Zhou M, Liang G, Elliott AM, Hazle JD, Myers JN, Li C, Stafford RJ. Targeted multi-functional gold-based nanoshells for MR-guided laser ablation of head and neck cancer. Biomaterials 32(30):7600-8, 2011. e-Pub 2011. PMID: 21745689.
81. Lu W, Melancon MP, Xiong C, Huang Q, Elliott A, Song S, Zhang R, Flores LG, Gelovani JG, Wang LV, Ku G, Stafford RJ, Li C. Effects of photoacoustic imaging and photothermal ablation therapy mediated by targeted hollow gold nanospheres in an orthotopic mouse xenograft model of glioma. Cancer Res 71(19):6116-21, 2011. e-Pub 2011. PMID: 21856744.
82. Tian M, Wen X, Jackson EF, Ng C, Uthamanthil R, Liang D, Gelovani JG, Li C. Pharmacokinetics and magnetic resonance imaging of biodegradable macromolecular blood-pool contrast agent PG-Gd in non-human primates: a pilot study. Contrast Media Mol Imaging 6(4):289-97, 2011. e-Pub 2011. PMID: 21861289.
83. Melancon MP, Elliott AM, Shetty A, Huang Q, Stafford RJ, Li C. Near-infrared light modulated photothermal effect increases vascular perfusion and enhances polymeric drug delivery. J Control Release 156(2):265-272, 2011. e-Pub 2011. PMID: 21763373.
84. Belousova N, Mikheeva G, Xiong C, Soghomonian S, Young D, Le Roux L, Naff K, Bidaut L, Wei W, Li C, Gelovani J, Krasnykh V. Development of a targeted gene vector platform based on simian adenovirus serotype 24. J Virol 84(19):10087-101, 2010. e-Pub 2010. PMID: 20631120.
85. You J, Shao R, Wei X, Gupta S, Li C. Near-infrared light triggers release of Paclitaxel from biodegradable microspheres: photothermal effect and enhanced antitumor activity. SMALL 6(9):1022-31, 2010. e-Pub 2010. PMID: 20394071.
86. Melancon MP, Lu W, Huang Q, Thapa P, Zhou D, Ng C, Li C. Targeted imaging of tumor-associated M2 macrophages using a macromolecular contrast agent PG-Gd-NIR813. Biomaterials 31(25):6567-73, 2010. e-Pub 2010. PMID: 20537382.
87. Lu W, Huang Q, Ku G, Wen X, Zhou M, Guzatov D, Brecht P, Su R, Oraevsky A, Wang LV, Li C. Photoacoustic imaging of living mouse brain vasculature using hollow gold nanospheres. Biomaterials 31(9):2617-26, 2010. e-Pub 2010. PMID: 20036000.
88. You J, Zhang G, Li C. Exceptionally high payload of doxorubicin in hollow gold nanospheres for near-infrared light-triggered drug release. ACS Nano 4(2):1033-41, 2010. e-Pub 2010. PMID: 20121065.
89. Zhou M, Zhang R, Huang M, Lu W, Song S, Melancon MP, Tian M, Liang D, Li C. A chelator-free multifunctional [64Cu]CuS nanoparticle platform for simultaneous micro-PET/CT imaging and photothermal ablation therapy. J Am Chem Soc 132(43):15351-8, 2010. e-Pub 2010. PMID: 20942456.
90. Fang C, Veiseh O, Kievit F, Bhattarai N, Wang F, Stephen Z, Li C, Lee D, Ellenbogen RG, Zhang M. Functionalization of iron oxide magnetic nanoparticles with targeting ligands: their physicochemical properties and in vivo behavior. Nanomedicine (London) 5(9):1357-69, 2010. e-Pub 2010. PMID: 21128719.
91. Li Y, Lu W, Huang Q, Huang M, Li C, Chen W. Copper sulfide nanoparticles for photothermal ablation of tumor cells. Nanomedicine (Lond) 5(8):1161-71, 2010. e-Pub 2010. PMID: 21039194.
92. Lu W, Zhang G, Zhang R, Flores LG, Huang Q, Gelovani JG, Li C. Tumor site-specific silencing of NF-kappaB p65 by targeted hollow gold nanosphere-mediated photothermal transfection. Cancer Res 70(8):3177-88, 2010. e-Pub 2010. PMID: 20388791.
93. Xiong C, Lu W, Zhang R, Tian M, Tong W, Gelovani J, Li C. Cell-permeable [99mTc(CO3)]-labeled fluorogenic caspase 3 substrate for dual-modality detection of apoptosis. Chemistry 15(36):8979-84, 2009. e-Pub 2009. PMID: 19637160.
94. Cao W, Bover L, Cho M, Wen X, Hanabuchi S, Bao M, Rosen DB, Wang YH, Shaw JL, Du Q, Li C, Arai N, Yao Z, Lanier LL, Liu YJ. Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. J Exp Med 206(7):1603-14, 2009. e-Pub 2009. PMID: 19564354.
95. Thapa P, Zhang G, Xia C, Gelbard A, Overwijk WW, Liu C, Hwu P, Chang DZ, Courtney A, Sastry JK, Wang PG, Li C, Zhou D. Nanoparticle formulated alpha-galactosylceramide activates NKT cells without inducing energy. Vaccine 27(25-26):3484-8, 2009. e-Pub 2009. PMID: 19200815.
96. Zhang G, Yang Z, Lu W, Zhang R, Huang Q, Tian M, Li L, Liang D, Li C. Influence of anchoring ligands and particle size on the colloidal stability and in vivo biodistribution of polyethylene glycol-coated gold nanoparticles in tumor-xenografted mice. Biomaterials 30(10):1928-36, 2009. e-Pub 2009. PMID: 19131103.
97. Yang Z, Leon J, Martin M, Harder JW, Zhang R, Liang D, Lu W, Tian M, Gelovani JG, Qiao A, Li C. Pharmacokinetics and biodistribution of near-infrared fluorescence polymeric nanoparticles. Nanotechnology 20(16):165101, 2009. e-Pub 2009. PMID: 19420561.
98. Yang Z, Kontoyiannis DP, Wen X, Xiong C, Zhang R, Albert ND, Li C. Gamma scintigraphy imaging of murine invasive pulmonary aspergillosis with a (111)In-labeled cyclic peptide. Nucl Med Biol 36(3):259-66, 2009. e-Pub 2009. PMID: 19324271.
99. Lu W, Xiong C, Zhang G, Huang Q, Zhang R, Zhang JZ, Li C. Targeted photothermal ablation of murine melanomas with melanocyte-stimulating hormone analog-conjugated hollow gold nanospheres. Clin Cancer Res 15(3):876-86, 2009. e-Pub 2009. PMID: 19188158.
100. Xiong C, Yang Z, Zhang R, Tong W, Gelovani J, Li C. 99mTc-labeled Ac-DEVD peptides as a substrate for measuring caspase activity. Adv Exp Med Biol 611:455-6, 2009. e-Pub 2009. PMID: 19400264.
101. Wang W, Shao R, Wu Q, Ke S, McMurray J, Lang FF, Charnsangavej C, Gelovani JG, Li C. Targeting gelatinases with a near-infrared fluorescent cyclic His-Try-Gly-Phe peptide. Mol Imaging Biol 11(6):424-33, 2009. e-Pub 2009. PMID: 19424760.
102. Melancon MP, Lu W, Yang Z, Zhang R, Cheng Z, Elliot AM, Stafford J, Olson T, Zhang JZ, Li C. In vitro and in vivo targeting of hollow gold nanoshells directed at epidermal growth factor receptor for photothermal ablation therapy. Mol Cancer Ther 7(6):1730-9, 2008. e-Pub 2008. PMID: 18566244.
103. Frank SJ, Stafford RJ, Bankson JA, Li C, Swanson DA, Kudchadker RJ, Martirosyan KS. A novel MRI marker for prostate brachytherapy. Int J Radiat Oncol Biol Phys 71(1):5-8, 2008. e-Pub 2008. PMID: 18406882.
104. Zhang G, Zhang R, Wen X, Li L, Li C. Micelles based on biodegradable poly(L-glutamic acid)-b-polylactide with paramagnetic Gd ions chelated to the shell layer as a potential nanoscale MRI-visible delivery system. Biomacromolecules 9(1):36-42, 2008. e-Pub 2008. PMID: 18047289.
105. M-L L, J-T O, Xie X, Ku G, Wang W, Li C, Lungu G, Stoica G, Wang LV. Simultaneous molecular and hypoxia imaging of brain tumors in vivo using spectroscopic photoacoustic tomography. Proceedings of the IEEE 96:481-9, 2008. e-Pub 2008.
106. Zou C, Brewer M, Cao X, Zhang R, Lin J, Deng Y, Li C. Antitumor activity of 4-(N-hydroxyphenyl)retinamide conjugated with poly(L-glutamic acid) against ovarian cancer xenografts. Gynecol Oncol 107(3):441-9, 2007. e-Pub 2007. PMID: 17854871.
107. Yang Z, Zheng S, Harrison WJ, Harder J, Wen X, Gelovani JG, Qiao A, Li C. Long-circulating near-infrared fluorescence core-cross-linked polymeric micelles: synthesis, characterization, and dual nuclear/optical imaging. Biomacromolecules 8(11):3422-8, 2007. e-Pub 2007. PMID: 17958440.
108. Park K, Liang G, Ji X, Luo ZP, Li C, Croft M, Markert JT. Structural and magnetic properties of gold and silica doubly coated γ-Fe2O3 nanoparticles. J Phys Chem, C 111(50):18512–19, 2007. e-Pub 2007.
109. Zhu G, Cao X, Chang JY, Milas L, Wallace S, Li C. Polymeric retinoid prodrug PG-4HPR enhances the radiation response of lung cancer. Oncol Rep 18(3):645-51, 2007. e-Pub 2007. PMID: 17671714.
110. Melancon MP, Wang Y, Wen X, Bankson JA, Stephens LC, Jasser S, Gelovani JG, Myers JN, Li C. Development of a macromolecular dual-modality MR-optical imaging for sentinel lymph node mapping. Invest Radiol 42(8):569-78, 2007. e-Pub 2007. PMID: 17620940.
111. Melancon MP, Wang W, Wang Y, Shao R, Ji X, Gelovani JG, Li C. A novel method for imaging in vivo degradation of poly(L-glutamic acid), a biodegradable drug carrier. Pharm Res 24(6):1217-24, 2007. e-Pub 2007. PMID: 17377742.
112. Ji X, Shao R, Elliott AM, Stafford RJ, Esparza-Coss E, Liang G, Luo ZP, Park K, Markert JT, Li C. Bifunctional gold nanoshells with a superparamagnetic iron oxide-silica core suitable for both MR imaging and photothermal therapy. J Phys Chem, C 111(17):6245, 2007. e-Pub 2007. PMID: 20165552.
113. Jackson EF, Esparza-Coss E, Wen X, Ng CS, Daniel SL, Price RE, Rivera B, Charnsangavej C, Gelovani JG, Li C. Magnetic resonance imaging of therapy-induced necrosis using gadolinium-chelated polyglutamic acids. Int J Radiat Oncol Biol Phys 68(3):830-8, 2007. e-Pub 2007. PMID: 17379450.
114. Shao R, Xiong C, Wen X, Gelovani JG, Li C. Targeting phosphatidylserine on apoptotic cells with phages and peptides selected from a bacteriophage display library. Mol Imaging 6(6):417-26, 2007. e-Pub 2007. PMID: 18053412.
115. Liu Y, Zhang W, Cheung LH, Niu T, Wu Q, Li C, Van Pelt CS, Rosenblum MG. The antimelanoma immunocytokine scFvMEL/TNF shows reduced toxicity and potent antitumor activity against human tumor xenografts. Neoplasia 8(5):384-93, 2006. e-Pub 2006. PMID: 16790087.
116. Li C, Wang W, Wu Q, Ke S, Houston J, Sevick-Muraca E, Dong L, Chow D, Charnsangavej C, Gelovani JG. Dual optical and nuclear imaging in human melanoma xenografts using a single targeted imaging probe. Nucl Med Biol 33(3):349-58, 2006. e-Pub 2006. PMID: 16631083.
117. Oh SH, Lee OH, Schroeder CP, Oh YW, Ke S, Cha HJ, Park RW, Onn A, Herbst RS, Li C, Lee HY. Antimetastatic activity of insulin-like growth factor binding protein-3 in lung cancer is mediated by insulin-like growth factor-independent urokinase-type plasminogen activator inhibition. Mol Cancer Ther 5(11):2685-95, 2006. e-Pub 2006. PMID: 17121915.
118. Wang W, McMurray JS, Wu Q, Campbell ML, Li C. Convenient solid-phase synthesis of diethylenetriaminepenta-acetic acid (DTPA)-conjugated cyclic RGD peptide analogues. Cancer Biother Radiopharm 20(5):547-56, 2005. e-Pub 2005. PMID: 16248770.
119. Hwang K, Houston JP, Rasmussen JC, Joshi A, Ke S, Li C, Sevick-Muraca EM. Improved excitation light rejection enhances small-animal fluorescent optical imaging. Mol Imaging 4(3):194-204, 2005. e-Pub 2005. PMID: 16194451.
120. Houston JP, Ke S, Wang W, Li C, Sevick-Muraca EM. Quality analysis of in vivo near-infrared fluorescence and conventional gamma images acquired using a dual-labeled tumor-targeting probe. J Biomed Opt 10(5):054010, 2005. e-Pub 2005. PMID: 16292970.
121. Gurfinkel M, Ke S, Wang W, Li C, Sevick-Muraca EM. Quantifying molecular specificity of avb3 integrin-targeted optical contrast agents with dynamic optical imaging. J Biomed Opt 10(3):034019, 2005. e-Pub 2005. PMID: 16229663.
122. Kwon S, Ke S, Houston JP, Wang W, Wu QP, Li C, Sevick-Muraca EM. Dose-dependent uptakes of an RGD-fluorescent dye-targeted to avb3 receptor expressed in Kaposi’s sarcoma. Mol Imaging 4(2):75-87, 2005. e-Pub 2005. PMID: 16105505.
123. Wang W, Wu Q, Pasuelo M, McMurray JS, Li C. Probing for integrin alpha v beta3 binding of RGD peptides using fluorescence polarization. Bioconjug Chem 16(3):729-34, 2005. e-Pub 2005. PMID: 15898744.
124. Wen X, Jackson EF, Price RE, Kim EE, Wu Q, Wallace S, Charnsangavej C, Gelovani JG, Li C. Synthesis and characterization of poly(L-glutamic acid) gadolinium chelate: a new biodegradable MRI contrast agent. Bioconjug Chem 15(6):1408-15, 2004. e-Pub 2004. PMID: 15546209.
125. Wang W, Ke S, Wu Q, Charnsangavej C, Gurfinkel M, Gelovani JG, Abbruzzese JL, Sevick-Muraca EM, Li C. Near-infrared optical imaging of integrin alphavbeta3 in human tumor xenografts. Mol Imaging 3(4):343-51, 2004. e-Pub 2004. PMID: 15802051.
126. Ke S, Wen X, Wu QP, Wallace S, Charnsangavej C, Stachowiak AM, Stephens CL, Abbruzzese JL, Podoloff DA, Li C. Imaging taxane-induced tumor apoptosis using PEGylated, 111In-labeled annexin V. J Nucl Med 45(1):108-15, 2004. e-Pub 2004. PMID: 14734682.
127. Tansey W, Ke S, Cao XY, Pasuelo MJ, Wallace S, Li C. Synthesis and characterization of branched poly(L-glutamic acid) as a biodegradable drug carrier. J Control Release 94(1):39-51, 2004. e-Pub 2004. PMID: 14684270.
128. Ke S, Wen X, Gurfinkel M, Charnsangavej C, Wallace S, Sevick-Muraca EM, Li C. Near-infrared optical imaging of epidermal growth factor receptor in breast cancer xenografts. Cancer Res 63(22):7870-5, 2003. e-Pub 2003. PMID: 14633715.
129. Wen X, Wu QP, Ke S, Wallace S, Charnsangavej C, Huang P, Liang D, Chow D, Li C. Improved radiolabeling of PEGylated protein: PEGylated annexin V for noninvasive imaging of tumor apoptosis. Cancer Biother Radiopharm 18(5):819-27, 2003. e-Pub 2003. PMID: 14629830.
130. Vega J, Ke S, Fan Z, Wallace S, Charnsangavej C, Li C. Targeting doxorubicin to epidermal growth factor receptors by site-specific conjugation of C225 to poly(L-glutamic acid) through a polyethylene glycol spacer. Pharm Res 20(5):826-32, 2003. e-Pub 2003. PMID: 12751641.
131. Milas L, Mason KA, Hunter N, Li C, Wallace S. Poly(L-glutamic acid)-paclitaxel conjugate is a potent enhancer of tumor radiocurability. Int J Radiat Oncol Biol Phys 55(3):707-12, 2003. e-Pub 2003. PMID: 12573758.
132. Le XF, Hittelman WN, Liu J, McWatters A, Li C, Mills GB, Bast RC. Paclitaxel-induced inactivation of p70 S6 kinase is associated with phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis. Oncogene 22(4):484-497, 2003. e-Pub 2003. PMID: 12555062.
133. Auzenne E, Donato NJ, Li C, Leroux E, Price RE, Farquhar D, Klostergaard J. Superior therapeutic profile of poly-L-glutamic acid-paclitaxel copolymer compared with taxol in xenogeneic compartmental models of human ovarian carcinoma. Clin Cancer Res 8(2):573-81, 2002. e-Pub 2002. PMID: 11839679.
134. X-X W, Q-P W, Ke S, Ellis L, Charnsangavej C, Delpassand AS, Wallace S, Li C. Conjugation with (111)In-DTPA-poly(ethylene glycol) improves imaging of anti-EGF receptor antibody C225. J Nucl Med 42(10):1530-37, 2001. e-Pub 2001. PMID: 11585869.
135. Wen X, Wu QP, Lu Y, Fan Z, Charnsangavej C, Wallace S, Chow D, Li C. Poly(ethylene glycol)-conjugated anti-EGF receptor antibody C225 with radiometal chelator attached to the termini of polymer chains. Bioconjug Chem 12(4):545-53, 2001. e-Pub 2001. PMID: 11459459.
136. Ke S, Milas L, Charnsangavej C, Wallace S, Li C. Potentiation of radioresponse by polymer-drug conjugates. J Control Release 74(1-3):237-42, 2001. e-Pub 2001. PMID: 11489500.
137. Zou Y, Wu QP, Tansey W, Chow D, Hung MC, Charnsangavej C, Wallace S, Li C. Effectiveness of water-soluble poly(L-glutamic acid)-camptothecin conjugate against resistant human lung cancer xenografted in nude mice. Int J Oncol 18(2):331-6, 2001. e-Pub 2001. PMID: 11172600.
138. Li C, Ke S, Wu QP, Tansey W, Hunter N, Buchmiller LM, Milas L, Charnsangavej C, Wallace S. Potentiation of ovarian OCa-1 tumor radioresponse by poly (L-glutamic acid)-paclitaxel conjugate. Int J Radiat Oncol Biol Phys 48(4):1119-26, 2000. e-Pub 2000. PMID: 11072171.
139. Li C, Newman RA, Wu QP, Ke S, Chen W, Hutto T, Kan Z, Brannan MD, Charnsangavej C, Wallace S. Biodistribution of paclitaxel and poly(L-glutamic acid)-paclitaxel conjugate in mice with ovarian OCa-1 tumor. Cancer Chemother Pharmacol 46(5):416-22, 2000. e-Pub 2000. PMID: 11127947.
140. Li C, Ke S, Wu QP, Tansey W, Hunter N, Buchmiller LM, Milas L, Charnsangavej C, Wallace S. Tumor irradiation enhances the tumor-specific distribution of poly(L-glutamic acid)-conjugated paclitaxel and its antitumor efficacy. Clin Cancer Res 6(7):2829-34, 2000. e-Pub 2000. PMID: 10914731.
141. Oldham EA, Li C, Ke S, Wallace S, Huang P. Comparison of action of paclitaxel and poly(L-glutamic acid)-paclitaxel conjugate in human breast cancer cells. Int J Oncol 16(1):125-32, 2000. e-Pub 2000. PMID: 10601557.
142. Inoue T, Li C, Yang DJ, Higuchi T, Oriuchi N, Yu D, Milas L, Hunter N, Wallace S, Kim EE, Podoloff DA. Evaluation of In-111 DTPA-paclitaxel scintigraphy to predict response on murine tumors to paclitaxel. Ann Nucl Med 13(3):169-74, 1999. e-Pub 1999. PMID: 10435377.
143. Li C, Price JE, Milas L, Hunter NR, Ke S, Yu DF, Charnsangavej C, Wallace S. Antitumor activity of poly(L-glutamic acid)-paclitaxel on syngeneic and xenografted tumors. Clin Cancer Res 5(4):891-7, 1999. e-Pub 1999. PMID: 10213226.
144. Multani AS, Li C, Ozen M, Imam AS, Wallace S, Pathak S. Cell-killing by paclitaxel in a metastatic murine melanoma cell line is mediated by extensive telomere erosion with no decrease in telomerase activity. Oncol Rep 6(1):39-44, 1999. e-Pub 1999. PMID: 9864398.
145. Li C, Yu DF, Newman RA, Cabral F, Stephens LC, Hunter N, Milas L, Wallace S. Complete regression of well-established tumors using a novel water-soluble poly(L-glutamic acid)-paclitaxel conjugate. Cancer Res 58(11):2404-9, 1998. e-Pub 1998. PMID: 9622081.
146. Multani AS, Li C, Ozen M, Yadav M, Yu DF, Wallace S, Pathak S. Paclitaxel and water-soluble poly (L-glutamic acid)-paclitaxel, induce direct chromosomal abnormalities and cell death in a murine metastatic melanoma cell line. Anticancer Res 17(6D):4269-74, 1997. e-Pub 1997. PMID: 9494519.
147. Li C, D-F Y, Inoue T, Yang DJ, Milas L, Hunter NR, Kim, EE, Wallace S. Synthesis, biodistribution and imaging properties of indium-111-DTPA-paclitaxel in mice bearing mammary tumors. J Nucl Med 38(7):1042-1047, 1997. e-Pub 1997. PMID: 9225788.
148. Li C, McCuskey P, D-F Y, Yang DJ, Z-X K, Wallace S. Development of biodegradable Ioxilan carbonate particles for contrast enhancement of the liver in computed tomography scanning: toxicity assessment. Acad Radiol 3:S:227-8, 1996. e-Pub 1996. PMID: 8796568.
149. Li C, D-F Y, Inoue T, Yang DJ, Milas L, Hunter NR, Kim EE, Wallace S. Synthesis and evaluation of water-soluble polyethylene glycol-paclitaxel conjugate as a paclitaxel prodrug. Anti-Cancer Drugs 7(6):642-648, 1996. e-Pub 1996. PMID: 8913432.
150. Li C, Yu D, Kan Z, Yang DJ, Tansey W, Kuang LR, Wallace S. Biodistribution of cyclic carbonate of ioxilan: a radiopaque particulate macrophage imaging agent. Acad Radiol 3(6):500-6, 1996. e-Pub 1996. PMID: 8796708.
151. Kim CG, Yang DJ, Kim EE, Cherif A, Kuang LR, Li C, Tansey W, Liu CW, Li SC, Wallace S, Podoloff DA. Assessment of tumor cell proliferation using [18F]fluorodeoxyadenosine and[18F]fluoroethyluracil. J Pharm Sci 85(3):339-44, 1996. e-Pub 1996. PMID: 8699341.
152. Yang DJ, Wallace S, Cherif A, Li C, Gretzer MB, Kim EE, Podoloff DA. Development of F-18-labeled fluoroerythronitroimidazole as a PET agent for imaging tumor hypoxia. Radiology 194(3):795-800, 1995. e-Pub 1995. PMID: 7862981.
153. Li C, Yang DJ, Nikiforow S, Tansey W, Kuang LR, Wright KC, Wallace S. Formation and characterization of cisplatin-loaded poly(benzyl l-glutamate) microspheres for chemoembolization. Pharm Res 11(12):1792-9, 1994. e-Pub 1994. PMID: 7534920.
154. Li C, Kan Z, Yang DJ, Kuang LR, Liu CW, Wright KC, Wallace S. Preparation, characterization, and evaluation of ioxilan carbonate particles for computed tomography contrast enhancement of liver. Invest Radiol 29(11):1006-13, 1994. e-Pub 1994. PMID: 7890508.
155. Li C, McCuskey P, Kan Z, Yang DJ, Wright KC, Wallace S. In vivo and electron microscopic studies of rat liver after intravenous injection of polyamino acid microspheres. J Biomed Mater Res 28(8):881-90, 1994. e-Pub 1994. PMID: 7527046.
156. Yang DJ, Kuang LR, Li C, Kan Z, Wallace S. Computed tomographic liver enhancement with poly(d,1-lactide)-microencapsulated contrast media. Invest Radiol 29(Suppl 2):S267-70, 1994. e-Pub 1994. PMID: 7928253.
157. Yang DJ, Li C, Nikiforow S, Gretzer MB, Kuang LR, Lopez MS, Vargas K, Wallace S. Diagnostic and therapeutic potential of poly(benzyl L-glutamate). J Pharm Sci 83(3):328-31, 1994. e-Pub 1994. PMID: 7515964.
158. Yang DJ, Li C, Kuang LR, Price JE, Buzdar AU, Tansey W, Cherif A, Gretzer M, Kim EE, Wallace S. Imaging, biodistribution and therapy potential of halogenated tamoxifen analogues. Life Sci 55(1):53-67, 1994. e-Pub 1994. PMID: 8015349.
159. Park K, Liang G, Ji X, Luo ZP, Li C, Croft M, Market, JT. Structural and Magnetic Properties of Gold and Silica Doubly Coated γ-Fe2O3 Nanoparticles. J. Phys. Chem 111(50):18512-19, 1993. e-Pub 1993.
160. Yang D, Kuang LR, Cherif A, Tansey W, Li C, Lin WJ, Liu CW, Kim EE, Wallace S. Synthesis of [18F]fluoroalanine and [18F]fluorotamoxifen for imaging breast tumors. J Drug Target 1(3):259-67, 1993. e-Pub 1993. PMID: 8069568.
161. Yang DJ, Cherif A, Tansey W, L-R K, Li C, Kim EE, Wallace S. N,N-Diethylfluoromethyltamoxifen: synthesis, assignment of 1H and 13C spectra, and receptor assay. Eur J Med Chem 27(9):919-924, 1992. e-Pub 1992.
162. Silver FH, Marks M, Kato YP, Li C, Pulapura S, Kohn J. Tissue compatibility of tyrosine-derived polycarbonates and polyiminocarbonates: an initial evaluation. J Long-Term Effects Med Impl 1(4):329-46, 1992. e-Pub 1992. PMID: 10171118.
163. Li C, Kohn J. Macromolecular backbone rearrangement: a new approach to the synthesis of N-phenyl substituted polyurethanes. Macromolecules 24(9):2302-2308, 1991. e-Pub 1991.
164. Pulapura S, Li C, Kohn J. Structure-property relationships for the design of polyiminocarbonates. Biomaterials 11(9):666-78, 1990. e-Pub 1990. PMID: 2090301.
165. Li C, Kohn J. Synthesis of poly(iminocarbonates): degradable polymers with potential applications as disposable plastics and as biomaterials. Macromolecules 22(5):2029-36, 1989. e-Pub 1989.

Invited Articles

1. Zhao J, Koay EJ, Li T, Wen X, Li C. A hindsight reflection on the clinical studies of poly(L-glutamic acid)-paclitaxel. Wiley Interdiscip Rev Nanomed Nanobiotechnol 10(3):e1497, 2018. e-Pub 2018. PMID: 28895304.
2. Zhao J, Zhou M, Li C. Synthetic nanoparticles for delivery of radioisotopes and radiosensitizers in cancer therapy. Cancer Nanotech 7:9, 2016. e-Pub 2016. PMID: 27909463.
3. Li J, Liu F, Gupta S, Li C. Interventional nanotheranostics of pancreatic ductal adenocarcinoma. Theranostics 6(9):1393-402, 2016. e-Pub 2016. PMID: 27375787.
4. Zhou M, Tian M, Li C. Copper-based nanomaterials for cancer imaging and therapy. Bioconjugate Chem 27(5):1188-99, 2016. e-Pub 2016. PMID: 27094828.
5. Gharpure KM, Wu SY, Li C, Lopez-Berestein G, Sood AK. Nanotechnology: Future of oncotherapy. Clin Cancer Res 21(14):3121-30, 2015. e-Pub 2015. PMID: 26180057.
6. Li C. A targeted approach to cancer imaging and therapy. Nat Mater 13(2):110-5, 2014. e-Pub 2014. PMID: 24452345.
7. Li J, Gupta S, Li C. Research perspectives: gold nanoparticles in cancer theranostics. Quant Imaging Med Surg 3(6):284-91, 2013. e-Pub 2013. PMID: 24404441.
8. Li C. Image-guided photonic energy deposition for cancer ablation and drug delivery. Curr Med Imaging Rev 8:267-277, 2012. e-Pub 2012.
9. Melancon MP, Stafford RJ, Li C. Challenges to effective cancer nanotheranostics. J Control Release 164(2):177-82, 2012. e-Pub 2012. PMID: 22906841.
10. Melancon MP, Li C. Multifunctional synthetic poly(L-glutamic acid)-based cancer therapeutic and imaging agents. Mol Imaging 10(1):28-42, 2011. e-Pub 2011. PMID: 21303613.
11. Melancon MP, Zhou M, Li C. Cancer theranostics with near-infrared light-activatable multimodal nanoparticles. Acc Chem Res 44(10):947-956, 2011. e-Pub 2011. PMID: 21848277.
12. Melancon M, Lu W, Li C. Gold-based magneto/optical nanostructures: Challenges for in vivo applications in cancer diagnostics and therapy. Mater Res Bull 34:415-421, 2009. e-Pub 2009.
13. Li C, Wallace S. Polymer-drug conjugates: Recent development in clinical oncology. Adv Drug Deliv Rev 60:886-98, 2008. e-Pub 2008.
14. Belhocine TZ, Tait JF, J-L V, Li C, Blankenberg FG. Nuclear medicine in the era of genomics and proteomics: lessons from annexin V (Perspectives). J Proteome Res 3:345-349, 2004. e-Pub 2004.
15. Belhocine T, Steinmetz N, Li C, Green A, Blankenberg FG. The imaging of apoptosis with radiolabeled Annexin V: Optimal timing for clinical feasibility. Tech Cancer Res Treat 3:23-32, 2004. e-Pub 2004.
16. Wen XX, Cao XY, Pasuelo MJ, Wendt R, Li C. Polymeric radiotracers in nuclear imaging. Curr Drug Deliv 1:377-384, 2004. e-Pub 2004.
17. Gurfinkel M, Ke S, Wen X, Li C, Sevick-Muraca EM. Near-infrared fluorescence optical imaging and tomography. Dis Markers 19(2-3):107-121, 2003. e-Pub 2003. PMID: 15096708.
18. Li C. Poly(L-glutamic acid)-anticancer drug conjugates. Adv Drug Deliv Rev 54:695-713, 2002. e-Pub 2002.
19. Wallace S, Kan Z, Li C. Hepatic chemoembolization: Clinical and experimental correlation. Acta Gastroenterol Belg 63(2):169-73, 2000. e-Pub 2000. PMID: 10925454.
20. Li C, Newman R, Wallace S. Reformulating paclitaxel. Science & Medicine 6:38-47, 1999. e-Pub 1999.

Other Articles

1. Cook S, Wittenburg L, Yan VC, Theil JH, Castillo D, Reagan KL, Williams S, Pham CD, Li C, Muller FL, Murphy BG Correction: Cook et al. An Optimized Bioassay for Screening Combined Anticoronaviral Compounds for Efficacy against Feline Infectious Peritonitis Virus with Pharmacokinetic Analyses of GS-441524, Remdesivir, and Molnupiravir in Cats. Viruses 2022, 14, 2429. Viruses 16(3), 2024. PMID: 38543851.
2. Zhou M, Zhao J, Tian M, Song S, Zhang R, Gupta S, Tan D, Shen H, Ferrari M, Li C Retraction: Radio-photothermal therapy mediated by a single compartment nanoplatform depletes tumor initiating cells and reduces lung metastasis in the orthotopic 4T1 breast tumor model. Nanoscale 15(34):14268, 2023. PMID: 37592914.

Abstracts

1. Li C, Shi† S, Cao Q, Sood AK, Molldrem JJ, Ma Q, Li C. Copper Sulfide Nanoparticle–Mediated Photothermolysis Induces Immunogenic Cell Death in Ovarian Cancer Cells. bioRxiv, 2025.
2. Cao QZ, Tang Y, Egan NA, Pan P, Long JP, Wang H, Burks JK, Liang H, Peng W, Li C. Investigating the mechanism of the abscopal effect in combined IRE and anti-PD-1 therapy against PDAC. AACR Annual Meeting 2025, 2025.
3. Cao QZ, Li C. microPET imaging of tumor infiltrating myeloid cells in pancreatic ductal adenocarcinoma (PDAC) using 64Cu-labeled anti-CD11b diabody. World Molecular Imaging Conference 2023, Prague, Czech Republic, 2023. e-Pub 2023.
4. Xiong CY, Wang R, Lu Y, Gao JJ, Li C. Immuno-PET with 64Cu-labeled antibody–drug conjugate targeting Nectin-4 in preclinical models of bladder cancer, 2023. e-Pub 2023.
5. Xiong CY, Wen YF, Sood AK, Li C. Novel theranostic agent targeting EphB4/EFNB2 signaling, 2023. e-Pub 2023.
6. Xiong CY, Li TT, Alpay M, Li C. 99mTc/Re tricarbonyl biguanide complexes for cancer theranostic. World Molecular Imaging Conference 2023. e-Pub 2023.
7. Li, C. Theranostic pair targeting mitochondria in pancreatic cancer cells, 2023. e-Pub 2023.
8. Dai L, Li, C, Yang P, Chow DSL. Polymeric Delivery with Dual Drug Payloads for Hepatocellular Carcinoma (HCC) Therapy. e-Pub 2022.
9. Paulo A, Li C. Proton boron capture therapy of pancreatic cancer (THER-PBCT), 2022. e-Pub 2022.
10. Lincha VR, Dagher F, Zhao J, Wen XX, Duong L, Li C, Chow DSL. Pharmacodynamic assessments of paclitaxel in combination with calcipotriol in pancreatic ductal adenocarcinoma (PDAC), 2022. e-Pub 2022.
11. Cao Q, Li C. µPET imaging of tumor-bearing mice using 64Cu-labeled anti-CD11b antibody, 2022. e-Pub 2022.
12. Xiong C, Li T, Alpay M, Li C. Tricarbonyl Biguanide Complexes for Cancer Theranostics:108-109, 2022. e-Pub 2022.
13. Shi SX, Li TT, Wen XF, Wen XX, Pagel MD, Li C. Anti-folate receptor 1 antibody-conjugated copper sulfide nanoparticles for in vivo multispectral optoacoustic tomography, 2019. e-Pub 2019.
14. Xiong CY, Du Y, Cao QZ, Alpay M, Mohan C, Li C. Two stage µPET/CT imaging of TCO-anti-CD11b with a 64Cu-NOTA-tetrazine tracer to monitor anti-GBM and lupus nephritis, 2019. e-Pub 2019.
15. X-X W, Li C. Concurrent injection of cold antibody allows PET imaging of orthotopic pancreatic tumor with 64Cu-labeled anti-PD-L1, 2019. e-Pub 2019.
16. Cao QZ, Wen XX, Du Y, Mohan C, Li C. μPET/CT imaging of experimental autoimmune nephritis using 64Cu-antiCD11b, 2019. e-Pub 2019.
17. Shi SX, Li TT, Cao QZ, Sood A, Li C. Radiolabeled exosomes for in vivo assessment of cancer homing potential, 2019. e-Pub 2019.
18. Zhao J, Wen XF, Li TT, Melancon MP, Gupta S, Peng WY, Li C. Irreversible electroporation induces immunogenic cell death and mediates durable response in orthotopic PDAC model in combination with anti-PD-1, 2019. e-Pub 2019.
19. Shi SX, Wen XX, Li TT, Li C. Thermosensitive biodegradable Copper Sulfide Nanoparticles for in vivo Multispectral Optoacoustic Tomography. 2018 SNMMI Annual Meeting, Philadelphia, PA, 2018. e-Pub 2018.
20. Zhao J, Xiao Z, Overwijk W, Li C. Pharmacological Modulation of Pancreatic Tumor - associated Stroma to Enhance Checkpoint Blockade Immunotherapy. 2018 AACR Annual Meeting, Chicago, IL, 2018. e-Pub 2018.
21. Cao Q, Huang Q, Li C. microPET/CT imaging of sentinel lymph nodes with tumor metastasis in B16Ova (Luc/GFP) melanoma bearing mice using 64 Cu-αCD11b. 2018 SNMMI Annual Meeting, Philadelphia, PA, 2018. e-Pub 2018.
22. Zhao J, Wang H, C-H H, Chow D, Kang Y, Maitra A, Piwnica-Worms D, Fleming J, Li C. Simultaneous targeting stroma and tumor cell compartments alleviates hypoxia, reduces inflammatory response, and enhances anti-PDAC therapy in KPC mice. 2017 Keystone Symposium on Cancer Immunology and Immunotherapy, Whistler, British Columbia, Canada, 2017. e-Pub 2017.
23. Wang W, Wen X, Zhao J, Lin CJ, Huang Q, Lin SY, Li C. Micro-PET/CT imaging of Axl expression in breast cancer xenografts and their response to 17-allylamino-17-demethoxygeldanamycin (17-AAG) treatment. 2016 SNMMI Annual Meeting, San Diego, CA, 2016. e-Pub 2016.
24. Zhao J, Li J, Wang W, Huang Q, Wen X, Li C. Pancreatic Cancer Therapy using Polyion Complex Micelles Loaded with Cyclopamine and Paclitaxel. 2016 11th International Symposium on Polymer Therapeutics, Valencia, Spain, 2016. e-Pub 2016.
25. Zhao J, Wu C, Wen X, Huang Q, Li C. Pancreatic cancer therapy using polyion micelles co-loaded with cyclopamine and paclitaxel. 2016 AACR Annual Meeting, New Orleans, LA, 2016. e-Pub 2016.
26. Cao Q, Huang Q, Li C. microPET/CT imaging of the mobilization of CD11b+ cells. 2016 AACR Annual Meeting, New Orleans, LA, 2016. e-Pub 2016.
27. Li J, Zhou M, Xiong C, Wang W, Cao Q, Wen X, Ji X, Wang YA, Gupta S, Li C. Intraarterial Delivery of Doxorubicin-Loaded Hollow Gold Nanospheres for Photothermal Ablation–Chemotherapy of Hepatocellular Carcinoma in the Liver of Rats. 2016 AACR Annual Meeting, New Orleans, LA, 2016. e-Pub 2016.
28. Zhou M, Song SL, Huang Q, Wen XX, Li C. Theranostic CuS nanoparticles targeting folate receptors for PET/CT image-guided photothermal ablation therapy. 2015 SNMMI Annual Meeting, Baltimore, MD, 2015. e-Pub 2015.
29. Cao QZ, Huang Q, Li C. microPET imaging of myeloid-derived suppressor cells using 64Cu-labeled anti-CD11b antibody in different tumor models. 2015 SNMMI Annual Meeting, Baltimore, MD, 2015. e-Pub 2015.
30. Xiong CY, Li JJ, Huang Q, Li C. Reduction of renal uptake of radiotracers by metformin co-administration. 2015 SNMMI Annual Meeting, Baltimore, MD, 2015. e-Pub 2015.
31. Cao QZ, Huang Q, Young D, Li C. microPET/CT imaging of local and systemic inflammatory response using 64Cu-labeled anti-CD11b Antibody. 2015 SNMMI Annual Meeting, Baltimore, MD, 2015. e-Pub 2015.
32. Qiao Y, Zhao J, Lee P, Vykoukal J, Wallace MJ, Li C, Gupta S, Melancon MP. Cell killing efficacy of combined electroporation and drug delivery of NVP-BEZ235. 2015 Society of Interventional Radiology (SIR) Annual Meeting, Atlanta, GA, 2015. e-Pub 2015.
33. Zhao J, Qiao Y, Vykoukal J, Wallace MJ, Li C, Gupta S, Melancon MP. Electroporation-enhanced delivery of doxorubicin-loaded nanoparticle in hepatocellular carcinoma xenograft. 2015 Society of Interventional Radiology (SIR) Annual Meeting, Atlanta, GA, 2015. e-Pub 2015.
34. Xiong C, Lu W, Zhou M, Wen X, Sood A, Li C. Cisplatin-loaded hollow gold nanospheres for NIR light-triggered release of cisplatin. 2014 Annual Principal Investigators Meeting - NCI Alliance for Nanotechnology in Cancer, Rockville, MD, 2014. e-Pub 2014.
35. Zhao J, Wu C, Abbruzzese J, Hwang RF, Li C. Cyclopamine-loaded core-crosslinked polymeric micelles enhance radiation response in pancreatic cancer and pancreatic stellate cells. 2014 Annual Principal Investigators Meeting - NCI Alliance for Nanotechnology in Cancer, Rockville, MD, 2014. e-Pub 2014.
36. Ku G, Zhou M, Huang Q, Li C. Photoacoustic imaging and photothermolysis treatment of tumors mediated by nanoparticles. 2014 SPIE Photonics West 2014, San Francisco, CA, 2014. e-Pub 2014.
37. Zhou M, Ku G, Huang Q, Pageon L, Sood A, Li C. Simultaneous in vivo photoacoustic imaging and confined photothermolysis by pulsed laser at 1064 nm in 4T1 breast cancer model. 2014 Annual Principal Investigators Meeting, NCI Alliance for Nanotechnology in Cancer, Rockville, MD, 2014. e-Pub 2014.
38. Tam AL, Melancon MP, Pageon L, Abdelsalam ME, Figueira TA, Dixon K, Miller J, McWatters A, Li C. Nanoparticle distribution after treatment of rabbit VX2 hepatic tumor with nanoparticle embolization and irreversible electroporation (IRE) or radiofrequency ablation (RFA). 2013 The Radiological Society of North American 99th Scientific Assembly and Annual Meeting, Chicago, IL, 2013. e-Pub 2013.
39. Cui L, Zhou M, Xiong C, Li C, Chow DSL. Integrin alpha(v)beta(3)-targeted [64Cu]CuS nanoparticles for PET/CT imaging and photothermal ablation therapy. 2013 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, San Antonio, TX, 2013. e-Pub 2013.
40. Ku G, Song S, Li C. Deeply penetrating photoacoustic imaging for cancer metastasis associated lymph node monitoring. Global Conference of Chinese Professionals in Nuclear Medicine (GCCPNMMI), Beijing, China, 2013. e-Pub 2013.
41. Ku G, Li C. Spectroscopic photoacoustic imaging for molecular imaging of animal tumor with nanoparticle targeting on tumor cells. 2013 Chinese Society of Molecular Imaging (CSMI), Xiamen, China, 2013. e-Pub 2013.
42. Cui L, Zhou M, Xiong C, Li C, Chow DSL. Development of targeted [64Cu]CuS nanoparticles for PET/CT imaging and photothermal ablation therapy. Controlled Release Society, 2013. e-Pub 2013.
43. Zhou M, Cui L, Zhao J, Huang Q, Wen X, Chow D, Li C. Radio-isotope doped copper sulfide nanoparticles: labeling efficiency, stability, pharmacokinetic and biodistribution. 2013 SNMMI Annual Meeting, Vancouver, British Columbia, Canada, 2013. e-Pub 2013.
44. Xiong C, Cao Q, Li C. PET/CT imaging of EphB4 receptors in melanoma xenograft with a 68Ga-labeled cyclic TNYL-RAW peptide. 2013 SNMMI Annual Meeting, Vancouver, British Columbia, Canada, 2013. e-Pub 2013.
45. Cao Q, Li C, Cheng Z. Macrophage as a potential tumor microenvironment target for imaging early response to anti-tumor therapy. 2013 SNMMI Annual Meeting, Vancouver, British Columbia, Canada, 2013. e-Pub 2013.
46. Zhou M, Song S, Melancon M, Huang Q, Wen X, Gupta S, Li C. Targeted CuS nanoparticles and near-infrared laser irradiation for photothermal ablation therapy of KB cervical tumor xenograft. 2013 SNMMI Annual Meeting, Vancouver, British Columbia, Canada, 2013. e-Pub 2013.
47. Zhou M, Song S, Melancon M, Huang Q, Wen X, Gupta S, Li C. Dual functional [64Cu]CuS nanoparticles for combined photothermal ablation and radiotherapy. 2013 SNMMI Annual Meeting, Vancouver, British Columbia, Canada, 2013. e-Pub 2013.
48. Zhou M, Ku G, Melancon M, Huang Q, Wen X, Gupta S, Li C. Theranostic CuS nanoparticles for photoacoustic imaging and photomechanical therapy. 2013 SNMMI Annual Meeting, Vancouver, British Columbia, Canada, 2013. e-Pub 2013.
49. Cao Q, Huang Q, Melancon M, Li C. Monitoring chemotherapy-induced bone marrow toxicity and the potential protective effect of anti-CSF-1 using microPET/CT with 64Cu-DOTA-anti-CD11b. 2013 SNMMI Annual Meeting, Vancouver, British Columbia, Canada, 2013. e-Pub 2013.
50. Zhao J, Tam AL, Melancon MP, McWatters A, Gupta S, Li C. Electroporation induced delivery of siRNA-loaded copper sulfide nanoparticles. 2013 Society of Interventional Radiology (SIR) Annual Scientific Meeting, New Orleans, LA, 2013. e-Pub 2013.
51. Lee H, Liu Y, Zhao J, Zhou M, Bouchard R, Wallace M, Li C, Gupta S, Melancon M. In vitro and in vivo mapping of drug release after laser ablation thermal therapy with Doxorubicin-loaded hollow gold nanoshells using fluorescence and photoacoustic imaging. 2013 Society of Interventional Radiology (SIR) Annual Scientific Meeting, New Orleans, LA, 2013. e-Pub 2013.
52. Cao QZ, Huang Q, Melancon MP, Li C. Imaging tumor-infiltrating macrophages as an early response marker of therapy-induced apoptosis. 2013 Ninth AACR-Japanese Cancer Association Joint Conference: Breakthroughs in Basic and Translational Cancer Research, Beijing, China, 2013. e-Pub 2013.
53. Zhou M, Song S, Li C. Radioactive [64Cu]CuS nanoparticles and near-infrared laser irradiation for combined radiotherapy and photothermal therapy: in-vivo feasibility study in an animal model. 2012 38th (SIR) Scientific Interventional Radiology Annual Scientific Meeting, San Francisco, CA, 2012. e-Pub 2012.
54. Melancon MP, Zerr JS, Stafford RJ, Zhou M, You J, Li C, Gupta S. Near-infrared laser-induced temperature changes mediated by systemically administered hollow gold nanoshells and intra-tumor laser fiber. JVIR 23(3S):S50, 2012. e-Pub 2012.
55. Melancon M, Vykoukai J, Abdelsalam M, Zhao J, Hazle J, Wallace MJ, Li C, Bankson J, Stafford J, Avritscher R. MR imaging for SPIO-labeled adipose-derived stem cells as a theranostic approach to management of liver injury. 2012 (ISMRM) International Society for Magnetic Resonance in Medicine Annual Meeting, Melbourne, Australia, 2012. e-Pub 2012.
56. Wen XX, DeLyria ES, Huang Q, Thapa P, Zhou DP, Li C. Antitumor efficacy and biodistribution of poly-L-glutamic acid conjugated CpG in mice bearing B16 melanoma. 2011 (WMIC) World Molecular Imaging Congress, San Diego, CA, 2011. e-Pub 2011.
57. Zhou M, Zhang R, Huang M, Melancon MP, Song S, Li C. A New chelator-free multifunctional semiconductor nanoparticle platform for simultaneous µPET/CT imaging and photothermal-radiotherapy. 2011 (GRC) Gordon Research Conferences-Cancer Nanotechnology, Waterville, ME, 2011. e-Pub 2011.
58. Huang M, Zhou M, Ku G, Battula VL, Andreeff M, Li C. Human mesenchymal stem cells loaded with [64Cu]CuS nanoparticles for dual-modality imaging of stem cell distribution in vivo. 2011 (SNM) Society of Nuclear Medicine Annual Meeting, San Antonio, TX, 2011. e-Pub 2011.
59. Zhou M, Zhang R, Huang M, Melancon MP, Song SL, Li C. A New chelator-free multifunctional [64Cu]-CuS nanoparticle platform for simultaneous µPET/CT imaging and radiotherapy. 2011 (SNM) Society of Nuclear Medicine Annual Meeting, San Antonio, TX, 2011. e-Pub 2011.
60. Zhang R, Lu W, Wen XX, Huang Q, Huang M, Yang Z, Zhou M, Li C. Annexin A5-functionalized nanoparticles for in vivo dual modality imaging of apoptosis. 2011 (SNM) Society of Nuclear Medicine Annual Meeting, San Antonio, TX, 2011. e-Pub 2011.
61. Ku G, You J, Zhang GD, Shen HF, Li C. Optical absorption and scattering comparison of various nanoparticles in near infrared by photoacoustic imaging and spectrophotometer. 2011 (SNM) Society of Nuclear Medicine Annual Meeting, San Antonio, TX, 2011. e-Pub 2011.
62. Song SL, Zhou M, Ku G, Flores-II L, Huang Q, Gelovani J, Li C. 64CuS nanoparticles as a dual PET/CT and photoacoustic imaging agent for sentinel lymph nodes mapping. 2011 (SNM) Society of Nuclear Medicine Annual Meeting, San Antonio, TX, 2011. e-Pub 2011.
63. Huang M, Xiong CY, Zhang R, Lu W, Huang Q, Flores II LG, Gelovani J, Li C. EphB4-binding peptide for dual modality µPET/CT and optical imaging of glioblastoma in orthotopic xenograft models. 2011 (SNM) Society of Nuclear Medicine Annual Meeting, San Antonio, TX, 2011. e-Pub 2011.
64. Xiong CY, Song SL, Li C. μPET imaging of EphA2 and EphB4 receptors in ovarian cancer xenografts using 64Cu-labeled YSA-TNYL heterodimer. 2011 (SNM) Society of Nuclear Medicine Annual Meeting, San Antonio, TX, 2011. e-Pub 2011.
65. Song SL, Xiong CY, Ku G, Li C. Novel apoptosis imaging biomarker early predicts chemotherapy response in preclinical models: a comparative study with 18F-FDG PET. 2011 (SNM) Society of Nuclear Medicine Annual Meeting, San Antonio, TX, 2011. e-Pub 2011.
66. Gupta S, Shaw C, Tian M, Lu W, Nazario J, Joseph E, Zhang R, Wright KC, Dixon K, Li C. Tumoral uptake of hollow gold nanospheres after intra-arterial and intravenous administration in an animal liver tumor model. J Vasc Interv Radiol Supplement 22(3S):S74, 2011. e-Pub 2011. PMID: 23608932.
67. Gupta S, Javadi S, Ozkan E, You J, Wright KC, Joseph E, Li C, Wallace MJ. Laser activated release of paclitaxel from biodegradable microspheres containing hollow gold nanospheres and paclitaxel administered intra-arterially into liver tumor in an animal model. JVIR 22(3S):S11, 2011. e-Pub 2011.
68. Xiong C, Li C. Towards improved pharmacokinetic profiles and increased metabolic stability of 64Cu-labeled peptides with high binding affinity to EphB4 receptors for PET. 2010 (WMIC) World Molecular Imaging Congress, Kyoto, Japan, 2010. e-Pub 2010.
69. Ku G, Zhou M, Zhong M, Hazle JD, Gelovani JG, Li C. Deeply penetrating photoacoustic tomography in biological tissues using CuS nanoparticles as optical contrast agents. 2010 (WMIC) World Molecular Imaging Congress, Kyoto, Japan, 2010. e-Pub 2010.
70. Melancon MP, Lu W, Elliott AM, Taylor B, Huang Q, Ng C, Hazle JD, Li C, Stafford RJ. MRI-guided thermal ablation using multimodality, multifunctional SPIO@Au nanoshell targeted to epidermal growth factor receptors. 2010 (WMIC) World Molecular Imaging Congress, Kyoto, Japan, 2010. e-Pub 2010.
71. Xiong C, Song S, Lu W, Zhang R, X-X W, Li C. Peptide-based imaging agents targeting phosphatidylserine for the detection of apoptosis. 2010 (WMIC) World Molecular Imaging Congress, Kyoto, Japan, 2010. e-Pub 2010.
72. Zhou M, Zhang R, Huang M, Lu W, Song S, Melancon MP, Tian M, Liang D, Li C. A new chelator-free multifunctional [64Cu]-CuS nanoparticle for simultaneous µPET/CT imaging and photothermal ablation therapy. 2010 (WMIC) World Molecular Imaging Congress, Kyoto, Japan, 2010. e-Pub 2010.
73. G-D Z, Melancon MP, Zhang R, You J, Li C. Biodegradable polymeric MRI agent: Poly(N-hydroxypropyl-L-glutamine)-DTPA-Gd. 2010 (WMIC) World Molecular Imaging Congress, Kyoto, Japan, 2010. e-Pub 2010.
74. Lu W, G-D Z, Zhang R, Flores II L, Huang Q, Gelovani JG, Li C. Photothermal transfection of siRNA under the guidance of PET/CT imaging using hollow gold nanospheres. 2010 (WMIC) World Molecular Imaging Congress, Kyoto, Japan, 2010. e-Pub 2010.
75. Xiong C, Huang M, Zhang R, Song S, Lu W, Flores II L, Gelovani JG, Li C. In vivo µPET/CT imaging of EphB4 receptors using 64Cu-labeled peptides. 2010 (WMIC) World Molecular Imaging Congress, Kyoto, Japan, 2010. e-Pub 2010.
76. Zhao J, Song S, You J, Li C. γ-Imaging of systemically administered biodegradable, core-crosslinked polymeric micelles as a potential drug carrier. 2010 (WMIC) World Molecular Imaging Congress, Kyoto, Japan, 2010. e-Pub 2010.
77. Zhang R, Lu W, X-X W, Huang Q, Huang M, Yang Z, Zhou M, Li C. Annexin V-functionalized nanoparticles for in vivo dual modality imaging of apoptosis. 2010 (WMIC) World Molecular Imaging Congress, Kyoto, Japan, 2010. e-Pub 2010.
78. Lu W, Melancon MP, Xiong C, Huang Q, Elliott A, Stafford RJ, Ku G, Gelovani JG, Li C. Brain tumor theranostics: photoacoustic tomography-guided thermal ablation mediated with targeted HAuNS. 2010 (WMIC) World Molecular Imaging Congress, Kyoto, Japan, 2010. e-Pub 2010.
79. Song S, Xiong C, Zhou M, Lu W, Huang Q, Ku G, Ni Y, Li C. µPET imaging of tumor necrosis induced by photothermal ablation therapy with 64Cu-hypericin. 2010 (WMIC) World Molecular Imaging Congress, Kyoto, Japan, 2010. e-Pub 2010.
80. Elliott AM, Shetty A, Melancon MP, X-J J, Taylor B, Hazle JD, Li C, Stafford RJ. MRTI evaluation of SPIO core gold coated nanoshells for thermal therapy and as T2* contrast agent. 2010 American Society of Mechanical Engineering (ASME), First Global Congress on NanoEngineering for Medicine and Biology (NEMB). Houston, TX, 2010. e-Pub 2010.
81. Li C, X-X W, Lu W, Thapa P, Hwu P, Zhou DP. Enhanced antitumor effect of water-soluble polymer-conjugated TLR9 ligand CpG ODN-2216 in a mouse model of melanoma. 2010 Keystone Symposia-Molecular and Cellular Biology of Immune Escape, Keystone, CO, 2010. e-Pub 2010.
82. Li C, Yang DJ, Kuang L-R, Wallace S. Polyamino acid microspheres: preparation, characterization, and distribution after intravenous injection in rats 94(1-3):143-152, 1993. e-Pub 1993.
83. Cao QZ, Egan NA, Peng W, Li C. The abscopal effect of combination IRE with αPD-1 treatment against PDACs. AACR 2024 Annual Meeting.
84. Teng QX, Zhang G, Mendes F, SahooN, Fernandes C, Paulo A, Li C. o-Carborane-entrapped polymeric Micelles for proton boron capture therapy. AACR 2024 Annual Meeting.
85. Gholizadeh AM, Dai L, Dagher F, Xiong C, Li C, Chow D S-L. Pharmacokinetic profiling of Re-phenformin in vivo: A novel approach in pancreatic cancer therapy. AACR 2024 Annual Meeting.
86. Dai L, Zhang G, Dagher F, Li C, Chow DSL. Polymeric delivery with dual drug payloads for hepatocellular carcinoma (HCC) therapy. AACR 2024 Annual Meeting.
87. Zhang, Teng Q, Chen H, Mendes F, Sahoo N, Fernandes C, Paolo A, Li C. o-Carborane-entrapped polymeric micelles for proton boron capture therapy. Controlled Release Society (CRS) Annual Meeting.
88. Xiong CY, Teng Q, Pan P, Jing B, Sood A, Wen Y, Li C. In vivo µPET/CT Imaging of EphB4 receptors agonist 64Cu-NOTA-BIDEN-AP in different tumor xenograft models with different Ephb4 expressing levels. World Molecular Imaging Conference (WMIC2024).
89. Cao QZ, Pagel MD, Kingsley CV, Sinharay S, Delacerda J, Ma J, Javadi S, Li C. Prediction of response to combined irreversible electroporation and immunotherapy in a preclinical model of pancreatic ductal adenocarcinoma with MRI. World Molecular Imaging Conference (WMIC2024),.
90. Xiong CY, Teng Q, Pan P, Jing B, Sood AK, Wen Y, Li C. Micro PET/CT imaging of EphA2 and EphB4 receptors in subcutaneous and orthotopic ovarian xenografts using 68Ga labeled BIDEN-AP-YSA heterodimeric peptide. World Molecular Imaging Conference (WMIC2024).
91. Cao QZ, Pagel MD, Ma J, Kingsley CV, Wang HM, Wen XX, Delacerda J, Javadi S, Li C. Multimodal MRI to predict response to irreversible electroporation plus anti-PD-1 immunotherapy in pancreatic ductal adenocarcinoma. 20th European Molecular Imaging Meeting (2025 EMIM.
92. Gholizadeh AM, Dagher F, Xiong CY, Li C, Diana S-L Chow. Comprehensive pharmacokinetics of Re-phenformin as an anticancer agent for pancreatic cancer therapy in mice: A comparative study with phenformin. AACR Annual Meeting 2025.
93. Xiong CY, Teng Q-X, Pan P, Vu TC, Wen Y, Li C. EphB4 agonist B4-007 was effectively against high-grade serous ovarian cancer (HGSC) as a single agent in cell-based and patient-derived xenograft models. AACR Annual Meeting 2025.
94. Jing B, Teng Q-X, Zhang GD, Xiong CY, Pan P, Cao QZ, Zhang N, Chen S, Peng W, Li C. Re-Phen, a novel OXPHOS enhancer that reprograms T cell mitochondrial metabolism to potentiate anti-PD-1 immunotherapy. AACR Annual Meeting 2025.
95. Teng Q-X, Zhang GD, Dai L, Deng D, Pan P, Chow DSL, Ma G, Sloan L, Yang P, Li C. Development and comprehensive preclinical evaluation of dual-drug polymeric micelles ONP-001 for PDAC and HCC. AACR Annual Meeting 2025.

Book Chapters

1. Zhou M, Li L, Yao J, Bouchard RR, Wang LV, Li C. Nanoparticles for Photoacoustic Imaging of Vasculature. In: Design and Applications of Nanoparticles in Biomedical Imaging. 1. Springer International Publishing, 337-356, 2017.
2. Zhao J, Li C. Polymeric micelles as imaging agents and drug delivery systems. In: Drug Delivery Applications of Noninvasive Imaging: Validation from Biodistribution to Sites of Action. John Wiley & Sons, 2014.
3. Lu W, Li C. Theranostics with hollow gold nanospheres. In: Theranostics with hollow gold nanospheres. John Wiley & Sons, 2014.
4. Li C. Nanotechnology and Cancer Therapy. In: Molecular Diagnosis and Personalized Cancer Medicine. Lippincott Williams & Wilkins, 2013.
5. Li C, Zhang JZ. Hollow gold nanospheres (HAuNS). In: Encyclopedia of Nanotechnology. Springer Verlag GmbH, 2012.
6. Lu W, Melancon MP, Li C. Theranostic applications of gold core-shell structured nanoparticles. In: Theranostic Nanoplatform-Based Molecular Imaging. John Wiley & Sons, Inc, 2012.
7. Melancon MP, X-X W, G-D Z, Li C. Multi-functional, multi-modality cancer imaging with water- soluble synthetic polymers. In: Nanoimaging. Pan Stanford Publishing Pte Ltd, 171-195, 2011.
8. Melancon MP, Li C. Core-shell magnetic nanomaterials in medical diagnosis and therapy. In: Magnetic Nanomaterials. Wiley-VCH Verlag GmbH & Co, 259-290, 2009.
9. G-D Z, Jackson E, Wallace S, Li C. Poly (L-glutamic acid): efficient carrier of cancer therapeutics and diagnostics. In: Nanotechnology for Cancer Therapeutics, 185-199, 2007.
10. Yang DJ, Li C, Kim EE. Imaging of anticancer drugs, response and prognosis. In: Targeted Imaging in Oncology. Springer-Verlag, 185-200, 2001.
11. Li C, Jackson E. Polymer-based compounds for targeted imaging. In: Targeted Imaging in Oncology. Springer-Verlag, 111-121, 2001.
12. Singer J, De Vries P, Bhatt R, Tulinsky J, Klein P, Li C, Milas L, Lewis RA, Wallace S. Conjugation of camptothecins to poly(L-glutamic acid). In: The Camptothecins: Unfolding Their Anticancer Potential. The New York Academy of Sciences, 136-150, 2000.
13. Yang DJ, Gretzer MB, L-R K, Cherif A, Li C, Diaz MF, C-W L, Emran A, Tansey W, Wallace S. Radiolabeled tamoxifen analogues for imaging breast cancer with SPECT. In: Chemists' View of Imaging Center. Plenum Publishing Corporation, 513-526, 1995.
14. Yang DJ, Wallace S, L-R K, Li C, Cherif A, Z-X K, McCuskey P, Wright KC. Microencapsulation, tamoxifen analogues and in vivo microscopy for tumor targeting. In: Cancer Treatment, An Update. Springer-Verlag, 817-819, 1994.
15. Yang DJ, L-R K, Li C, C-W L, Tsai T, Lin WJ, Tansey W, Nikiforow S, McCuskey P, Z-X K, Wright KC, Wallace S. Evaluation of poly(dl-lactide) encapsulated radiopaque microspheres. In: Polymeric Delivery System. American Chemistry Society, 372-382, 1992.

Books (edited and written)

1. Li C, Tian M. Drug Delivery Applications of Noninvasive Imaging: Validation from Biodistribution to Sites of Action. John Wiley & Sons, 2014.
2. Li C, Currell FJ. Nanomaterials to Enhance the Effect of Ionizing Radiation. Springer Nature.

Web Publications

1. Li, Dan, Shi, Sixiang, Cao, Qizhen, Sood, Anil K, Molldrem, Jeffrey J, Ma, Qing, Li, Chun. Copper Sulfide Nanoparticle–Mediated Photothermolysis Induces Immunogenic Cell Death in Ovarian Cancer Cells, 2025.
2. Yan VC, Pham CD, Yan MJ, Yan AJ, Khadka S, Arthur K, Ackroyd JJ, Georgiou DK, Roon LE, Bushman LR, Anderson PL, Li C, Muller FL. Pharmacokinetics of orally administered GS-441524 in dogs, 2021. PMCID: PMC8183013.

Patents

1. Li C, Kohn J. Synthesis of Poly (Iminocarbonates). Patent Number: U.S. Patent No. 5,264,537.
2. Zhou, Li C, Hwu P. Tumor Targeted Delivery of Immunomodulators by Nanopolymers (MDA10-045). Patent Number: Provisional application serial No. 61/301,252, 2/4/2010; United States, No. US13/577,207, PCT/US2011/023609 (publication number WO2011/097384); Chinese patent number CN103002919B.
3. Li C, Wallace S, Yu DF, Yang DJ. Water Soluble Paclitaxel Derivatives. Patent Number: U.S. patent No. 6,515,017.
4. Li C, Wang W, Melancon MP, Gelovani JG, Myers J. Imaging Agents and Methods (MDA05-121). Patent Number: U.S. Patent 12/227,185; PCT/US07/68783.
5. Wallace S, Yang DJ, Wallace M, Li C, Kuang LR. Therapeutic and Diagnostic Use of Surface Modified Microcapsules. Patent Number: U.S. Patent No. 5,848,584.
6. Wallace S, Yang DJ, Wallace M, Li C, Kuang LR. Efficient Microcapsules Preparation and Method of Use. Patent Number: Application No. 90766/91, Patent No. 659622.
7. Li C, Wallace S, Yu DF, Yang DJ. Water Soluble Paclitaxel Derivatives. Patent Number: U.S. Patent No. 6,730,699.
8. Li C, Kohn J. Synthesis of Poly (Iminocarbonates). Patent Number: U.S. No. 5,140,094.
9. Gelovani JG, Tong W, Najjar A, Li C. Agents for Imaging Apoptosis (MDA06-060). Patent Number: U.S.12/298,386; PCT/US07/68596.
10. Li C, Tansey WL, Charnsangavej C, Wallace S. Dendritic Poly(amino acid) Carriers (MDA01-066). Patent Number: U.S. patent No. 10/327,455.
11. Li C, Zhao J, Fleming J. Polymeric Drug Delivery Systems for Treatment of Disease (MDA15-087). Patent Number: U.S. patent No. 11,026,889; Chinese patent application No. 201680081255.2.
12. Li C, Kohn J. Poly (N-Substituted Iminocarbonates) and Poly (N-Phenyl Urethane) Derived There From. Patent Number: U.S. Patent No. 5,242,997.
13. Li C, Wallace S, D-F Y, Yang DJ. Water Soluble Paclitaxel Derivatives. Patent Number: U.S. Patent No. 6,884,817 B2.
14. Li C, Wallace S, Kan Z, Yang DJ, Kuang LR. Particulate Contrast Media Derived from Non-ionic Water-Soluble contrast Agents for CT Enhancement of Hepatic Tumors. Patent Number: U.S. Patent No. 5,686,061.
15. D-P Z, Li C. Nanoparticle Formulated Glycolipid Antigens for Immunotherapy (MDA09-016). Patent Number: Provisional application, serial No. 61/146,725; PCT/CN2010/000100 (publication number WO 2010/083728 A1), 1/23/2009; U.S. Patent No. 8546371.
16. Li C, Wang W, Ke S. Cyclic Peptides for Targeted Imaging and Therapy (MDA03-086). Patent Number: U.S. Patent No. 7,371,364.
17. Li C, Wallace S, Yu DF, Yang, DJ. Water Soluble Paclitaxel Derivatives. Patent Number: U.S. Patent No. 6,441,025.