Chunru Lin
Department of Molecular and Cellular Oncology, Division of Basic Sciences
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Molecular and Cellular Oncology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Associate Professor, Graduate School of Biomedical Sciences (GSBS), The University of Texas Health Science Center, Houston, TX
Education & Training
Degree-Granting Education
| 2006 | Georgia State University, Atlanta, GA, USA, PHD, Biological Science |
| 1999 | Hunan Medical University, Changsha, CHN, MD, General Medicine |
Postgraduate Training
| 2006-2013 | Postdoctoral Fellow, University of California, San Diego, San Diego, CA |
Experience & Service
Academic Appointments
Assistant Professor, Department of Molecular and Cellular Oncology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 2013 - 2019
Assistant Professor, Graduate School of Biomedical Sciences (GSBS), The University of Texas Health Science Center, Houston, TX, 2013 - 2019
Honors & Awards
| 2020 | President’s Recognition of Faculty Excellence, MD Anderson Cancer Center |
| 2019 | DOD Breakthrough Award, Department of Defense |
| 2019 | Wall of Science Award for Outstanding Scientific Research, MD Anderson Cancer Center |
| 2019 | 2019 Sanofi-Cell Research Outstanding Research Article Award, Cell Research |
| 2019 | Sanofi-Cell Research Outstanding Research Article Award, Sanofi |
| 2018 | Wall of Science Award for Outstanding Scientific Research, Institutional Research Executive Committee, MD Anderson |
| 2014 | Wall of Science Award for Outstanding Scientific Research, Institutional Research Executive Committee, MD Anderson |
| 2013 | Faculty Science and Technology Acquisition and Retention (STARs) Program, University of Texas |
| 2011 | Pathway to Independence Award, National Institute of Health |
| 2008 | Susan G. Komen Postdoctoral Fellowship Grant, Susan G. Komen |
Selected Publications
Peer-Reviewed Articles
- Li Y, Tan Z, Zhang Y, Zhang Z, Hu Q, Liang K, Jun Y, Ye Y, Li YC, Li C, Liao L, Xu J, Xing Z, Pan Y, Chatterjee SS, Nguyen TK, Hsiao H, Egranov SD, Putluri N, Coarfa C, Hawke DH, Gunaratne PH, Tsai KL, Han L, Hung MC, Calin GA, Namour F, Guéant JL, Muntau AC, Blau N, Sutton VR, Schiff M, Feillet F, Zhang S, Lin C, Yang L. A noncoding RNA modulator potentiates phenylalanine metabolism in mice. Science 373(6555):662-673, 2021. PMID: 34353949.
- Zhang Y, Li Y, Hu Q, Xi Y, Xing Z, Zhang Z, Huang L, Wu J, Liang K, Nguyen TK, Egranov SD, Sun C, Zhao Z, Hawke DH, Li J, Sun D, Kim JJ, Zhang P, Cheng J, Farida A, Hung MC, Han L, Darabi R, Lin C, Yang L. The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin. Nat Cell Biol 22(11):1332-1345, 2020. e-Pub 2020. PMID: 33106653.
- Li Y, Hu Q, Li C, Liang K, Xiang Y, Hsiao H, Nguyen TK, Park PK, Egranov SD, Ambati CR, Putluri N, Hawke DH, Han L, Hung MC, Danesh FR, Yang L, Lin C. PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease. J Clin Invest 129(3):1129-1151, 2019. e-Pub 2019. PMID: 30741721.
- Zhen Xing, Yanyan Zhang, Ke Liang, Liang Yan, Yu Xiang, Chunlai Li, Qingsong Hu, Feng Jin, Vasanta Putluri, Nagireddy Putluri, Cristian Coarfa, Arun Sreekumar, Peter K Park, Tina Kim Nguyen, Shouyu Wang, Jianwei Zhou, Yan Zhou, Jeffrey R. Marks, David H. Hawke, Mien-Chie Hung, Liuqing Yang, Leng Han, Haoqiang Ying and Chunru Lin. Expression of long non-coding RNA YIYA promotes glycolysis in breast cancer. Cancer Research, 2018. e-Pub 2018.
- Lin C, Yang L. Long Noncoding RNA in Cancer: Wiring Signaling Circuitry. Trends Cell Biol 28(4):287-301, 2018. e-Pub 2017. PMID: 29274663.
- Lin A, Hu Q, Li C, Xing Z, Ma G, Wang C, Li J, Ye Y, Yao J, Liang K, Wang S, Park PK, Marks JR, Zhou Y, Zhou J, Hung MC, Liang H, Hu Z, Shen H, Hawke DH, Han L, Zhou Y, Lin C, Yang L. The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors. Nat Cell Biol 19(3):238-251, 2017. e-Pub 2017. PMID: 28218907.
- Li C, Wang S, Xing Z, Lin A, Liang K, Song J, Hu Q, Yao J, Chen Z, Park PK, Hawke DH, Zhou J, Zhou Y, Zhang S, Liang H, Hung MC, Gallick GE, Han L, Lin C, Yang L. A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis. Nat Cell Biol 19(2):106-119, 2017. e-Pub 2017. PMID: 28114269.
- Lin A, Li C, Xing Z, Hu Q, Liang K, Han L, Wang C, Hawke DH, Wang S, Zhang Y, Wei Y, Ma G, Park PK, Zhou J, Zhou Y, Hu Z, Zhou Y, Marks JR, Liang H, Hung MC, Lin C, Yang L. The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer. Nat Cell Biol 18(2):213-24, 2016. e-Pub 2016. PMID: 26751287.
- Xing Z, Lin A, Li C, Liang K, Wang S, Liu Y, Park PK, Qin L, Wei Y, Hawke DH, Hung MC, Lin C, Yang L. LncRNA Directs Cooperative Epigenetic Regulation Downstream of Chemokine Signals. Cell 159(5):1110-25, 2014. e-Pub 2014. PMID: 25416949.
- Yang L, Lin C, Jin C, Yang JC, Tanasa B, Li W, Merkurjev D, Ohgi KA, Meng D, Zhang J, Evans CP, Rosenfeld MG. lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs. Nature 500(7464):598-602, 2013. e-Pub 2013. PMID: 23945587.
- Yang L, Lin C, Liu W, Zhang J, Ohgi KA, Grinstein JD, Dorrestein PC, Rosenfeld MG. ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs. Cell 147(4):773-88, 2011. PMID: 22078878.
- Yajuan Li, Yaohua Zhang, Qingsong Hu, Sergey D. Egranov, Zhen Xing, Zhao Zhang, Ke Liang, Youqiong Ye, Yinghong Pan, Sujash S. Chatterjee, Brandon Mistretta, Tina K. Nguyen, David H. Hawke, Preethi H. Gunaratne, Mien-Chie Hung, Leng Han, Liuqing Yang and Chunru Lin. Functional Significance of Gain-of-Function H19 in Skeletal Muscle Differentiation and Anti-obesity Effects. Genome Medicine.
- Hu Q, Ye Y, Chan LC, Li Y, Liang K, Lin A, Egranov SD, Zhang Y, Xia W, Gong J, Pan Y, Chatterjee SS, Yao J, Evans KW, Nguyen TK, Park PK, Liu J, Coarfa C, Donepudi SR, Putluri V, Putluri N, Sreekumar A, Ambati CR, Hawke DH, Marks JR, Gunaratne PH, Caudle AS, Sahin AA, Hortobagyi GN, Meric-Bernstam F, Chen L, Yu D, Hung MC, Curran MA, Han L, Lin C, Yang L. Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. Nat Immunol. e-Pub 2019. PMID: 31160797.
- Hu Q, Li C, Wang S, Li Y, Wen B, Zhang Y, Liang K, Yao J, Ye Y, Hsiao H, Nguyen TK, Park PK, Egranov SD, Hawke DH, Marks JR, Han L, Hung MC, Zhang B, Lin C, Yang L. LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition. Cell Res. e-Pub 2019. PMID: 30631154.
Grant & Contract Support
| Title: | Significance of Inhibiting Long Non-coding RNAs in Advanced Breast Cancer |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | PTEN Promotes Diabetic breast cancer metastasis |
| Funding Source: | Cancer Prevention & Research Institute of Texas (CPRIT) |
| Role: | Principal Investigator |
| Title: | Molecular Mechanism Elucidation and Therapeutic Strategies against TNBC Chemotherapy-Induced Metastasis |
| Funding Source: | DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP) |
| Role: | Principal Investigator |
| Title: | Development of Long non-coding RNA-directed Target Therapy for Triple-Negative Breast Cancer |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Systematic Characterization of Small Nucleolar RNAs in Cancer |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| Title: | Long Noncoding RNA Advocates Immune Resistant Microenvironment |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Title: | Long Noncoding RNA-Targeted Therapy Alleviate Duchenne and Becker Muscular Dystrophy |
| Funding Source: | Department of Defense (DOD) |
| Role: | Principal Investigator |