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Chunru Lin

Department of Molecular and Cellular Oncology, Division of Discovery Science

In the News

Sickle cell disease changes DNA structure of cells to suppress...

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Molecular and Cellular Oncology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Associate Professor, Graduate School of Biomedical Sciences (GSBS), The University of Texas Health Science Center, Houston, TX

Education & Training

Degree-Granting Education

2006	Georgia State University, Atlanta, GA, USA, PHD, Biological Science
1999	Hunan Medical University, Changsha, CHN, MD, General Medicine

Postgraduate Training

2006-2013

Postdoctoral Fellow, University of California, San Diego, San Diego, CA

Experience & Service

Faculty Academic Appointments

Assistant Professor, Department of Molecular and Cellular Oncology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 2013 - 2019

Assistant Professor, Graduate School of Biomedical Sciences (GSBS), The University of Texas Health Science Center, Houston, TX, 2013 - 2019

Honors & Awards

2020 - Present	President’s Recognition of Faculty Excellence, MD Anderson Cancer Center
2019 - 2022	DOD Breakthrough Award, Department of Defense
2019 - 2020	Wall of Science Award for Outstanding Scientific Research, MD Anderson Cancer Center
2019	2019 Sanofi-Cell Research Outstanding Research Article Award, Cell Research
2019	Sanofi-Cell Research Outstanding Research Article Award, Sanofi
2018 - 2019	Wall of Science Award for Outstanding Scientific Research, Institutional Research Executive Committee, MD Anderson
2014 - 2015	Wall of Science Award for Outstanding Scientific Research, Institutional Research Executive Committee, MD Anderson
2013 - 2016	Faculty Science and Technology Acquisition and Retention (STARs) Program, University of Texas
2011 - 2017	Pathway to Independence Award, National Institute of Health
2008	Susan G. Komen Postdoctoral Fellowship Grant, Susan G. Komen

Grant & Contract Support

Date:	2021 - 2024
Title:	Long Noncoding RNA Advocates Immune Resistant Microenvironment
Funding Source:	NIH/NCI
Role:	Principal Investigator
ID:	3 R01 CA231011-03S1

Date:	2021 - 2023
Title:	Long Noncoding RNA-Targeted Therapy Alleviate Duchenne and Becker Muscular Dystrophy
Funding Source:	Department of Defense (DOD)
Role:	Principal Investigator
ID:	MD00001

Date:	2019 - 2022
Title:	Molecular Mechanism Elucidation and Therapeutic Strategies against TNBC Chemotherapy-Induced Metastasis
Funding Source:	DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP)
Role:	Principal Investigator
ID:	BC180196

Date:	2019 - 2024
Title:	Development of Long non-coding RNA-directed Target Therapy for Triple-Negative Breast Cancer
Funding Source:	NIH/NCI
Role:	Principal Investigator
ID:	1R01CA231011-01A1

Date:	2018 - 2022
Title:	PTEN Promotes Diabetic breast cancer metastasis
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	Principal Investigator
ID:	RP180259

Date:	2017 - 2021
Title:	Significance of Inhibiting Long Non-coding RNAs in Advanced Breast Cancer
Funding Source:	NIH/NCI
Role:	Principal Investigator
ID:	1R01CA218025-01

Selected Publications

Peer-Reviewed Articles

Li Y, Tan Z, Zhang Y, Zhang Z, Hu Q, Liang K, Jun Y, Ye Y, Li YC, Li C, Liao L, Xu J, Xing Z, Pan Y, Chatterjee SS, Nguyen TK, Hsiao H, Egranov SD, Putluri N, Coarfa C, Hawke DH, Gunaratne PH, Tsai KL, Han L, Hung MC, Calin GA, Namour F, Guéant JL, Muntau AC, Blau N, Sutton VR, Schiff M, Feillet F, Zhang S, Lin C, Yang L. A noncoding RNA modulator potentiates phenylalanine metabolism in mice. Science 373(6555):662-673, 2021. PMID: 34353949.
Zhang Y, Li Y, Hu Q, Xi Y, Xing Z, Zhang Z, Huang L, Wu J, Liang K, Nguyen TK, Egranov SD, Sun C, Zhao Z, Hawke DH, Li J, Sun D, Kim JJ, Zhang P, Cheng J, Farida A, Hung MC, Han L, Darabi R, Lin C, Yang L. The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin. Nat Cell Biol 22(11):1332-1345, 2020. e-Pub 2020. PMID: 33106653.
Hu Q, Ye Y, Chan LC, Li Y, Liang K, Lin A, Egranov SD, Zhang Y, Xia W, Gong J, Pan Y, Chatterjee SS, Yao J, Evans KW, Nguyen TK, Park PK, Liu J, Coarfa C, Donepudi SR, Putluri V, Putluri N, Sreekumar A, Ambati CR, Hawke DH, Marks JR, Gunaratne PH, Caudle AS, Sahin AA, Hortobagyi GN, Meric-Bernstam F, Chen L, Yu D, Hung MC, Curran MA, Han L, Lin C, Yang L. Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. Nat Immunol. e-Pub 2019. PMID: 31160797.
Li Y, Hu Q, Li C, Liang K, Xiang Y, Hsiao H, Nguyen TK, Park PK, Egranov SD, Ambati CR, Putluri N, Hawke DH, Han L, Hung MC, Danesh FR, Yang L, Lin C. PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease. J Clin Invest 129(3):1129-1151, 2019. e-Pub 2019. PMID: 30741721.
Hu Q, Li C, Wang S, Li Y, Wen B, Zhang Y, Liang K, Yao J, Ye Y, Hsiao H, Nguyen TK, Park PK, Egranov SD, Hawke DH, Marks JR, Han L, Hung MC, Zhang B, Lin C, Yang L. LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition. Cell Res. e-Pub 2019. PMID: 30631154.
Zhen Xing, Yanyan Zhang, Ke Liang, Liang Yan, Yu Xiang, Chunlai Li, Qingsong Hu, Feng Jin, Vasanta Putluri, Nagireddy Putluri, Cristian Coarfa, Arun Sreekumar, Peter K Park, Tina Kim Nguyen, Shouyu Wang, Jianwei Zhou, Yan Zhou, Jeffrey R. Marks, David H. Hawke, Mien-Chie Hung, Liuqing Yang, Leng Han, Haoqiang Ying and Chunru Lin. Expression of long non-coding RNA YIYA promotes glycolysis in breast cancer. Cancer Research, 2018. e-Pub 2018.
Lin C, Yang L. Long Noncoding RNA in Cancer: Wiring Signaling Circuitry. Trends Cell Biol 28(4):287-301, 2018. e-Pub 2017. PMID: 29274663.
Lin A, Hu Q, Li C, Xing Z, Ma G, Wang C, Li J, Ye Y, Yao J, Liang K, Wang S, Park PK, Marks JR, Zhou Y, Zhou J, Hung MC, Liang H, Hu Z, Shen H, Hawke DH, Han L, Zhou Y, Lin C, Yang L. The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors. Nat Cell Biol 19(3):238-251, 2017. e-Pub 2017. PMID: 28218907.
Li C, Wang S, Xing Z, Lin A, Liang K, Song J, Hu Q, Yao J, Chen Z, Park PK, Hawke DH, Zhou J, Zhou Y, Zhang S, Liang H, Hung MC, Gallick GE, Han L, Lin C, Yang L. A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis. Nat Cell Biol 19(2):106-119, 2017. e-Pub 2017. PMID: 28114269.
Lin A, Li C, Xing Z, Hu Q, Liang K, Han L, Wang C, Hawke DH, Wang S, Zhang Y, Wei Y, Ma G, Park PK, Zhou J, Zhou Y, Hu Z, Zhou Y, Marks JR, Liang H, Hung MC, Lin C, Yang L. The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer. Nat Cell Biol 18(2):213-24, 2016. e-Pub 2016. PMID: 26751287.
Xing Z, Lin A, Li C, Liang K, Wang S, Liu Y, Park PK, Qin L, Wei Y, Hawke DH, Hung MC, Lin C, Yang L. LncRNA Directs Cooperative Epigenetic Regulation Downstream of Chemokine Signals. Cell 159(5):1110-25, 2014. e-Pub 2014. PMID: 25416949.
Yang L, Lin C, Jin C, Yang JC, Tanasa B, Li W, Merkurjev D, Ohgi KA, Meng D, Zhang J, Evans CP, Rosenfeld MG. lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs. Nature 500(7464):598-602, 2013. e-Pub 2013. PMID: 23945587.
Yang L, Lin C, Liu W, Zhang J, Ohgi KA, Grinstein JD, Dorrestein PC, Rosenfeld MG. ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs. Cell 147(4):773-88, 2011. PMID: 22078878.