Cynthia E. Herzog, MD
Department of Pediatrics, Division of Pediatrics
Present Title & Affiliation
Primary Appointment
Professor, Department of Pediatrics Patient Care, Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 1985 | University of Texas Medical Branch, Galveston, TX, USA, MD, Medicine |
| 1979 | Rice University, Houston, TX, USA, BA, Biochemistry |
Postgraduate Training
| 2004-2005 | Faculty Leadership Training, M. D. Anderson Cancer Center, Houston, TX |
| 1991-1992 | Senior Assistant Surgeon, National Cancer Institute, Bethesda, MD |
| 1988-1991 | Fellow in Pediatric Hematology-Oncology, National Cancer Institute, Bethesda, MD |
| 1985-1988 | Pediatric Residency, Children's Medical Center, Dallas, TX |
Board Certifications
| 1992 | The American Board of Pediatrics, Hematology/Oncology, Sub-Board of Pediatrics |
Experience & Service
Academic Appointments
Associate Professor, Department of Pediatrics Patient Care, Division of Pediatrics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 2001 - 2008
Assistant Professor, Department of Pediatrics Patient Care, Division of Pediatrics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 1995 - 2001
Faculty Associate, Department of Pediatrics Patient Care, Division of Pediatrics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 1992 - 1995
Administrative Appointments/Responsibilities
Center Medical Director- Child and Adolescent Center, The University of Texas MD Anderson Cancer Center, Houston, TX, 2015 - 2019
Section Chief, Department of Pediatrics Patient Care, The University of Texas MD Anderson Cancer Center, Houston, 2013 - 2015
Medical Director, Department of Clinical Research Department, The University of Texas MD Anderson Cancer Center, Houston, TX, 2009 - 2013
Other Appointments/Responsibilities
Deputy Director, POETIC Clinical Program, New York, NY, 2014 - Present
Chair, POETIC Performance and Compliance Committee, New York, NY, 2013 - Present
Board of Director, POETIC Foundation, New York, NY, 2013 - Present
Coordinating Committee Member, The Retinoblastoma Center of Houston, Houston, TX, 2009 - Present
Advisory Board, Ronald MacDonald House, Houston, TX, 2001 - 2003
Physician Auditor, Office of Protocol Research Quality Assurance, Houston, 1998 - 1999
Honors & Awards
| 2005 | The Best Doctors in America |
| 2003 | Multi Year Appointment Award |
| 2001 | The Best Doctors in America |
| 1998 | The Best Doctors in America |
Selected Publications
Peer-Reviewed Articles
- Moyers JT, Carmagnani Pestana R, Roszik J, Hong DS, Naing A, Fu S, Piha-Paul S, Yap T, Karp D, Rodon J, Livingston JA, Zarzour MA, Ravi V, Patel S, Benjamin RS, Ludwig J, Herzog C, Ratan R, Somaiah N, Conley A, Gorlick R, Meric-Bernstam F, Subbiah V. Examining Stripes on a Herd of Zebras: Impact of Genomic Matching for Ultrarare Sarcomas in Phase 1 Clinical Trials (SAMBA 102). Clin Cancer Res. e-Pub 2022. PMID: 36288393.
- Wright KD, Yao X, London WB, Kao PC, Gore L, Hunger S, Geyer R, Cohen KJ, Allen JC, Katzenstein HM, Smith A, Boklan J, Nazemi K, Trippett T, Karajannis M, Herzog C, Destefano J, Direnzo J, Pietrantonio J, Greenspan L, Cassidy D, Schissel D, Perentesis J, Basu M, Mizuno T, Vinks AA, Prabhu SP, Chi SN, Kieran MW. A POETIC Phase II study of continuous oral everolimus in recurrent, radiographically progressive pediatric low-grade glioma. Pediatr Blood Cancer 68(2):e28787, 2021. e-Pub 2020. PMID: 33140540.
- Dao L, Ragoonanan D, Batth I, Satelli A, Foglesong J, Wang J, Zaky W, Gill JB, Liu D, Albert A, Gordon N, Huh W, Harrison D, Herzog CE, Kleinerman E, Gorlick R, Daw N, Li S. Prognostic Value of Cell-Surface Vimentin-Positive CTCs in Pediatric Sarcomas. Front Oncol 11:760267, 2021. e-Pub 2021. PMID: 34956881.
- Tarek N, Said R, Andersen CR, Suki TS, Foglesong J, Herzog CE, Tannir NM, Patel S, Ratan R, Ludwig JA, Daw NC. Primary Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Kidney: The MD Anderson Cancer Center Experience. Cancers (Basel) 12(10), 2020. e-Pub 2020. PMID: 33050651.
- Groisberg R, Roszik J, Conley AP, Lazar AJ, Portal DE, Hong DS, Naing A, Herzog CE, Somaiah N, Zarzour MA, Patel S, Brown RE, Subbiah V. Genomics, Morphoproteomics, and Treatment Patterns of Patients with Alveolar Soft Part Sarcoma and Response to Multiple Experimental Therapies. Mol Cancer Ther 19(5):1165-1172, 2020. e-Pub 2020. PMID: 32127467.
- Sa HS, Rubin ML, Ning J, Li W, Tetzlaff MT, McGovern SL, Paulino AC, Herzog CE, Gill JB, Esmaeli B. Association of T and N Categories of the American Joint Commission on Cancer, 8th Edition, With Metastasis and Survival in Patients with Orbital Sarcoma. JAMA Ophthalmol 138(4):374-381, 2020. e-Pub 2020. PMID: 32105303.
- Area C, Yen CJ, Chevez-Barrios P, Herzog C, Kan P, Zheng W, Lin F, Chintagumpala M, Gombos D, Chen SR. Technical and anatomical factors affecting intra-arterial chemotherapy fluoroscopy time and radiation dose for intraocular retinoblastoma. J Neurointerv Surg 11(12):1273-1276, 2019. e-Pub 2019. PMID: 31197028.
- Subbiah V, Lamhamedi-Cherradi SE, Cuglievan B, Menegaz BA, Camacho P, Huh W, Ramamoorthy V, Anderson PM, Pollock RE, Lev DC, Qiao W, McAleer MF, Benjamin RS, Patel S, Herzog C, Daw NC, Feig BW, Lazar AJ, Hayes-Jordan A, Ludwig JA. Multimodality Treatment of Desmoplastic Small Round Cell Tumor: Chemotherapy and Complete Cytoreductive Surgery Improve Patient Survival. Clin Cancer Res 24(19):4865-4873, 2018. e-Pub 2018. PMID: 29871905.
- Manley PE, Trippett T, Smith AA, Macy ME, Leary SES, Boklan J, Cohen KJ, Goldman S, Kilburn LB, Dhall G, Devin J, Herzog C, Partap S, Fauchet F, Badreddine E, Bernard JP, Chi SN. A phase 1/2 dose-finding, safety, and activity study of cabazitaxel in pediatric patients with refractory solid tumors including tumors of the central nervous system. Pediatr Blood Cancer 65(9):e27217, 2018. e-Pub 2018. PMID: 29750396.
- Hayes-Jordan AA, Coakley BA, Green HL, Xiao L, Fournier KF, Herzog CE, Ludwig JA, McAleer MF, Anderson PM, Huh WW. Desmoplastic Small Round Cell Tumor Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: Results of a Phase 2 Trial. Ann Surg Oncol 25(4):872-877, 2018. e-Pub 2018. PMID: 29383611.
- Cuglievan B, Subbiah V, Wang H, Morani A, Meric-Bernstam F, Holla V, Herzog CE. Response to Mammalian Target of Rapamycin-Based Therapy and Incidental Finding of Lynch Syndrome in a Patient with Solid Pseudopapillary Neoplasm of the Pancreas With AKT1_E17K Mutation. JCO Precis Oncol 2, 2018. e-Pub 2018. PMID: 31650099.
- Tarek N, Hayes-Jordan A, Salvador L, McAleer MF, Herzog CE, Huh WW. Recurrent desmoplastic small round cell tumor responding to an mTOR inhibitor containing regimen. Pediatr Blood Cancer 65(1), 2018. e-Pub 2017. PMID: 28941151.
- Geoerger B, Bergeron C, Gore L, Sender L, Dunkel IJ, Herzog C, Brochez L, Cruz O, Nysom K, Berghorn E, Simsek B, Shen J, Pappo A. Phase II study of ipilimumab in adolescents with unresectable stage III or IV malignant melanoma. Eur J Cancer 86:358-363, 2017. e-Pub 2017. PMID: 29100190.
- Dembla V, Groisberg R, Hess K, Fu S, Wheler J, Hong DS, Janku F, Zinner R, Piha-Paul SA, Ravi V, Benjamin RS, Patel S, Somaiah N, Herzog CE, Karp DD, Roszik J, Meric-Bernstam F, Subbiah V. Outcomes of patients with sarcoma enrolled in clinical trials of pazopanib combined with histone deacetylase, mTOR, Her2, or MEK inhibitors. Sci Rep 7(1):15963, 2017. e-Pub 2017. PMID: 29162825.
- Amram AL, Rico G, Kim JW, Chintagumpala M, Herzog CE, Gombos DS, Chévez-Barrios P. Vitreous Seeds in Retinoblastoma: Clinicopathologic Classification and Correlation. Ophthalmology 124(10):1540-1547, 2017. e-Pub 2017. PMID: 28528011.
- Kumar R, Vu L, Madewell JE, Herzog CE, Bird JE. Glomangiomatosis of the sciatic nerve: a case report and review of the literature. Skeletal Radiol 46(6):807-815, 2017. e-Pub 2017. PMID: 28303299.
- Groisberg R, Hong DS, Holla V, Janku F, Piha-Paul S, Ravi V, Benjamin R, Kumar Patel S, Somaiah N, Conley A, Ali SM, Schrock AB, Ross JS, Stephens PJ, Miller VA, Sen S, Herzog C, Meric-Bernstam F, Subbiah V. Clinical genomic profiling to identify actionable alterations for investigational therapies in patients with diverse sarcomas. Oncotarget 8(24):39254-39267, 2017. PMID: 28424409.
- Huh WW, Daw NC, Herzog CE, Munsell MF, McAleer MF, Lewis VO. Ewing sarcoma family of tumors in children younger than 10 years of age. Pediatr Blood Cancer 64(4), 2017. e-Pub 2016. PMID: 27696711.
Abstracts
- Friedman DL, Schremp E, Koyama T, Sun L, Kehler LA, Daniels A, Shah AC, Dimaras H, Nagarajan R, Hayashi RJ, Schmidt ML, Chintagumpala MM, Herzog CE, Luna-Fineman S, Fraley CE, Weinstein J, Olson TA, Bruce Crooks B, Cindy L. Schwartz CL, Joseph Philip Neglia JP. Outcomes of patients with bilateral retinoblastoma: A report from the RIVERBOAT Consortium. J Clin Oncol 40, 2022. e-Pub 2022.
- Sarkar S, Throckmorton W, Bingham R, Msaouel P, Genovese G, Slopis J, Rao P, Sadighi Z, Herzog, C. Renal cell carcinoma, unclassified, with medullary phenotype in a patient with neurofibromatosis type 2. Children’s Tumor Foundation 2022 NF Conference, 2022.
- Gordon NB, Kleinerman E, Sheshadri A, Blanco D, Yedururi S, Morani A, Gill JB, Harrison DJ, Herzog C, Livingston JA, Benjamin RC, Gorlick RG, Mireles ME, Kawedia JD, Daw NC. A phase I trial of aerosol gemcitabine for the treatment of patients with solid tumors and lung metastases. J Clin Oncol 38:2020. e-Pub 2022.
- Friedman DL, Schremp E, Koyama T, Sun L, Kehler LA, Daniels A, Hayashi RJ, Shah AC, Dimaras H, Nagarajan R, Schmidt ML, Chintagumpala MM, Herzog CE, Luna-Fineman S, Fraley CE, Weinstein J, Olson TA, Bruce Crooks B, Cindy L. Schwartz CL, Joseph Philip Neglia JP. Outcomes of patients with Unilateral retinoblastoma: A report from the RIVERBOAT Consortium, 2022.
- Dao L, Foglesong J, Batth I, Zaky W, Gill JB, Liu D, Albert A, Gordon N, Huh W, Harrison D, Herzog C, Kleinerman E, Gorlick R, Daw NC, Li S. Enumeration of Cell Surface Vimentin Positive Cells as a Method for Detecting Circultatin Tumor Cells in Pediatric Patients with Sarcoma. Connective Tissue Oncology Society Tokyo, Japan, 2019.
- Chen SR, Chévez-Barrios P, Chintagumpala M, Lin FY, Kan P, Chen DL, Herzog CE, Gombos DS. Quantitative Evaluation of Factors Affecting Tumor Size Reduction on Wide Angle Fundus Camera Following Retinoblastoma Chemotherapy. Journal of NeuroInterventional Surgery A128. DOI:10.1136/neurintsurg-2019-SNIS.221, 2019.
- Groisberg R, Roszik J, Sen S, Conley AP, Lazar AJ, Hong DS, Naing A, Herzog C, Somaiah N, Zarzour MA, Patel S, Subbiah V. Treatment Patterns of Alveolar Soft Part Sarcoma Patients and Response to Multiple Experimental Therapies. CTOS Rome, Italy, 2018.
- Subbiah V, Lamhamedi-Cherradi SE, Cuglievan B, Huh W, Anderson P, Pollock R, Lev D, Qiao W, McAleer MF, Benjamin R, Patel S, Herzog C, Daw N, Feig B, Lazar AJ, Hayes-Jordan A, Ludwig JA. Improved 3 and 5 Year Survival with Multimodality Treatment of Desmoplastic Small Round Cell Tumor. CTOS Rome, Italy, 2018.
- Yen C, Santiago F, Rad MG, Chévez-Barrios P, Herzog C, Kan P, Chintagumpala M, Lin F, Gombos D, Chen S. Five Year Retrospective Review of Chemosurgery for Retinoblastoma: Significant TechniqueRelated Differences and Opportunity for Improving Outcomes. Society of NeuroInterventional Surgery, San Francisco, CA, 2018.
- Phadnis S, Huh WW,Herzog CE, Daw NC, Harrison, DJ, Ward EN, Piha-Paul S, Bhatt T, Mote EP, Gorlick R, Meric-Bernstam F, Schwartz CL, Subbiah V. Phase I study of Everolimus (mTOR inhibitor) in combination with Vandetanib (multikinase inhibitor of EGFR, VEGFR, and RET) in children, adolescents and young adults with sarcoma and other advanced solid tumors. CTOS Maui, Hawaii, 2017.
- Pappo A, Bergeron C, Gore L, Sender L, Dunkel IJ, Herzog C, Brochez L, Cruz O, Nysom K, Berghorn E, Simsek B, Shen J, Geoerger B. Phase II study of ipilimumab (IPI) in children and adolescents with unresectable stage III or IV mlaginant melanoma (MEL). ASCO 2017, 2017.
- Chen SR, Chevez-Barrios P, Herzog CE, Lin FY, Chintagumpala M, Gombos DS. Histopathologic observations of intra-arterial chemotherapy in a xenograft rabbit retinoblastoma model. International Society of Ocular Oncology 2022 Annual Meeting Leiden, The Netherlands (June 18, 2022).
Book Chapters
- Tarek N,Herzog CE. Retinoblastoma. In: Nelson Textbook of Pediatrics. 21st. Elsevier Saunders: Philadelphia PA, pp 2697-2698, 2019.
- Herzog CE, Huh WW. Gonadal and Germ Cell Neoplasms. In: Nelson Textbook of Pediatrics. 21st. Elsevier Saunders: Philadelphia, PA, pp 2698-2700, 2019.
- Herzog CE. Benign Vascular Tumors. In: Nelson Textbook of Pediatrics. 21st. Elsevier Saunders: Philadelphia, PA, pp 2700-02, 2019.
- Herzog CE, Huh WW, Tarek N, Waguespack S. Rare Tumors. In: Nelson Textbook of Pediatrics. 21st. Elsevier Saunders: Philadelphia, PA, pp 2703-05, 2019.
- Tarek, N, Herzog CE. Neoplasms of the Liver. In: Nelson Textbook of Pediatrics. Elsevier Saunders: Philadelphia, PA, pp 2702-03, 2019.
Grant & Contract Support
| Title: | Research Into Visual Endpoints and RB Health Outcomes After Treatment: The Riverboat Consortium |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |