Daoyan Wei, PhD
Department of Gastroenterology & Hepatology, Division of Internal Medicine
About Dr. Daoyan Wei
I am an associate professor in the Department of Gastroenterology, Hepatology and Nutrition at MD Anderson. My research leverages patient-derived models, genetically engineered mouse models, and molecular and cellular biological approaches to elucidate the molecular mechanisms underlying the initiation, progression, and therapeutic resistance of gastrointestinal cancers, particularly pancreatic cancer. Our ultimate goal is to develop novel early detection methods and effective intervention strategies to improve the outcomes of these diseases.
Present Title & Affiliation
Primary Appointment
Associate Professor, Gastroenterology - Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2000 | Shanghai Jiaotong University, P.R, CN, Molecular Biology & Biochemistry, Ph.D |
| 1990 | Anhui Medical University, P.R, CN, Radiation Medicine, M.S |
Postgraduate Training
| 2001-2004 | Postdoctoral Fellow, Department of Gastrointestinal Medical Oncology, Cancer Biology, The University of Texas MD Anderson cancer Center, Houston, Texas |
| 2000-2001 | Postdoctoral Fellow, School of Dentistry, Biochemistry and molecular biology, The University of Michigan, Ann Arbor, Michigan |
Experience & Service
Faculty Academic Appointments
Assistant Professor, Gastroenterology - Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 2013 - 2020
Assistant Professor, Gastrointestinal (GI) Medical Oncology - Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 2010 - 2013
Instructor, Gastrointestinal (GI) Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2004 - 2010
Intramural Institutional Committee Activities
Member, DoIM Research Committee, The University of Texas MD Anderson Cancer Center, 2022 - Present
Member, Academic Review Committee, The University of Texas MD Anderson Cancer Center, 2021 - Present
Editorial Activities
Editorial Board Member, Current Stem Cell Research & Therapy, 2025 - Present
Guest editor for a special issue, International Journal of Molecular Sciences, 2024 - 2026
Editorial Board Member, Austin Journal of Gastroenterology, 2014 - 2022
Editorial Board Member, World Journal of Gastroenterology, 2014 - 2016
Board member, Advancements in Genetic Engineering, 2012 - 2023
Honors & Awards
| 2021 | A finalist for the Cyrus Scholar Award for Outstanding Basic Research, Division of Internal Medicine (DoIM), The University of MD Anderson Cancer Center |
| 2019 | A finalist for the Cyrus Scholar Award for Outstanding Basic Research, DoIM, The University of Texas MD Anderson Cancer Center |
| 2016 | A finalist for the Cyrus Scholar Award for Outstanding Basic Research, DoIM, The University of Texas MD Anderson Cancer Center |
| 2010 | Travel Award for 4th Mayo Clinic Angiogenesis Symposium, Mayo Clinic Cancer Center |
| 2006 | AACR-PanCAN Career Development Award, American Association for Cancer Research |
| 2004 | Travel Fellowship Award, The 2004 Gastrointestinal Oncology Conference |
| 2002 | Honorable award, 6th Annual Trainee Recognition Day, MD Anderson Cancer Center |
| 2002 | Travel Fellowship Award, The 2002 Gastrointestinal Cancer Research Conference |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2025. Krüppel-like factor 4 (KLF4): A critical player in pancreatic cancer initiation and progression. Invited. Division of Internal Medicine (DoIM) Research Grand Rounds. Houston, TX, US.
- 2022. Dysregulated Vitamin D/VDR-MUC1 signaling confers gemcitabine resistance in pancreatic cancer. Invited. DoIM Research Grand Rounds. Houston, Texas, US.
- 2021. Activation of vitamin D/VDR signaling reverses gemcitabine resistance of pancreatic cancer cells through inhibition of MUC1 expression. Invited. 2021 DoIM Research Retreat. Houston, Texas, US.
- 2019. Drastic upregulation of GKN2 expression unveils the dedifferentiation mechanism of KLF4 in promoting pancreatic cancer initiation. Invited. 2019 DoIM Research Retreat. Houston, Texas, US.
- 2016. Essential Role of KLF4 for Acinar to Ductal Reprogramming during Pancreatic Cancer Initiation. Invited. 2016 DoIM Research Retreat. Houston, Texas, US.
- 2008. p53-Sp1 signaling in pancreatic cancer. Invited. MD Anderson Center Pancreatic Cancer Research Seminar Series. Houston, TX, US.
Regional Presentations
- 2008. SP1/KLF4 transcription factors: the alterations and implications in pancreatic cancer. Invited. Department of Surgery Seminar Series at Baylor college of Medicine. Houston, TX, US.
- 2008. The alterations and mechanisms of Sp1/KLF4 transcription factors in human gastric cancer. Invited. Carver college of Medicine Seminar Series. Iowa, Iowa, US.
- 2007. Critical roles and mechanistic actions of Sp1/KLF4 transcription factors in gastric cancer. Invited. Department of Internal Medicine Seminar Series. Charlottesville, Virginia, US.
National Presentations
- 2024. Biofield therapy suppressed invasion and metastases of human pancreatic cancer. Poster. AACR Annual Meeting 2024. San Diego, CA, US.
- 2021. Activation of vitamin D/VDR signaling reverses gemcitabine resistance of pancreatic cancer cells through inhibition of MUC1 expression. Poster. AACR Annual Meeting 2022. New Orleans, Louisana, US.
- 2016. KLF4 is essential for induction of cellular identity change and acinar to ductal reprogramming during early pancreatic carcinogenesis. Invited. KLF and SP transcrition factors in disease and regenerative medicine-Special Science Research Conferences. Snowmass, Colorado, US.
- 2009. Altered expression of KLF4α promotes cell cycle progression and is associated with worse prognosis in patients with pancreatic ductal adenocarcinoma. Poster. AACR 100th Annual Meeting. Denver, Colarado, US.
- 2008. Identification and validation of Sp1 as a critical regulator of angiogenesis in human pancreatic cancer by coupling gene knockdown and cDNA microarray Analyses. Poster. American Association for Cancer Research 98th Annual Meeting. San Diego, CA, US.
- 2007. KLF4 up-regulates p27Kip1 expression and inhibits the growth and metastasis of human pancreatic cancer. Poster. American Association for Cancer Research 97th Annual Meeting. Los Angeles, CA, US.
International Presentations
- 2024. Biofield therapy suppresses pancreatic cancer cell growth and metastasis in part through FOXM1 signaling pathway. Invited. 21st International Conference of the Society for Integrative Oncology. Los Angeles, US.
Grant & Contract Support
| Date: | 2024 - 2028 |
| Title: | Dissecting and targeting tumor-stroma interactions in pancreatic cancer |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | 1 R01 CA279110 |
| Date: | 2023 - 2028 |
| Title: | Multi-cancer early detection using cell-free DNA methylome analysis |
| Funding Source: | NIH |
| Role: | Key |
| ID: | 1U01CA285010-01 |
| Date: | 2023 - 2028 |
| Title: | Molecular understanding of pancreatic cancer initiation |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | 1 R01 CA275960 |
| Date: | 2022 - 2026 |
| Title: | Unveiling mechanisms underlying therapeutic resistance of pancreatic cancer |
| Funding Source: | IRG Grant |
| Role: | PI |
| ID: | IRG-125092 |
| Date: | 2021 - 2027 |
| Title: | Molecular Understanding and Targeting of Determinant Factors in Gastric Tumorigenesis |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1R01 CA236905 |
| Date: | 2021 - 2026 |
| Title: | Biofield Therapy in Oncology Phase III |
| Funding Source: | Emerald Gate |
| Role: | Co-I |
| ID: | LS-00061373 |
| Date: | 2020 - 2023 |
| Title: | Novel biomarkers for early detection and intervention of pancreatic neoplasms |
| Funding Source: | Duncan Family Institute Foundation |
| Role: | PI |
| ID: | DFI-7029 |
| Date: | 2019 - 2024 |
| Title: | WNT/b-Catenin signaling in pancreatic oncogenesis |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | R01CA220236 |
| Date: | 2019 - 2024 |
| Title: | Development of Compound Kushen Injection (CKI) products |
| Funding Source: | ZhenDong Pharmaceuticals |
| Role: | Collaborator |
| ID: | Strategic Collaboration Agreement |
| Date: | 2019 - 2023 |
| Title: | Development of novel liquid biopsy for early detection and risk prediction of pancreatic neoplasms |
| Funding Source: | Elsa U Pardee Foundation |
| Role: | PI |
| ID: | FP00006319 |
| Date: | 2017 - 2020 |
| Title: | Molecular mechanisms of pancreatic cancer initiation |
| Funding Source: | MD Anderson Cancer Center Institutional Research Grant |
| Role: | PI |
| ID: | IRG |
| Date: | 2016 - 2023 |
| Title: | Integrated signaling in pancreatic cancer progression |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1R01CA198090 |
| Date: | 2015 - 2025 |
| Title: | Clinical Significance of Pancreatic Cancer Differentiation and Dedifferentiation |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | R01CA195651 |
| Date: | 2015 - 2016 |
| Title: | The role of KLF4 in pancreatic injury and regeneration |
| Funding Source: | The Texas Medical Center Digestive Diseases Center |
| Role: | PI |
| ID: | DDC-Pilot |
| Date: | 2013 - 2015 |
| Title: | Molecular mechanisms of pancreatic cancer pathogenesis |
| Funding Source: | MD Anderson Institutional Research Grant |
| Role: | PI |
| ID: | IRG |
| Date: | 2013 - 2020 |
| Title: | Molecular Mediators of Pancreatic Cancer Invasion and Progression |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1R01CA172233 |
| Date: | 2011 - 2013 |
| Title: | Dietary DIM in pancreatic cancer prevention and therapy |
| Funding Source: | American Institute for Cancer Research (AICR) |
| Role: | PI |
| ID: | AICR Grant |
| Date: | 2010 - 2015 |
| Title: | Genetic approaches to pancreatic cancer progression |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1R01CA148954 |
| Date: | 2010 - 2016 |
| Title: | Functional validation of pancreatic cancer progression biomarkers |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 5R01CA152309 |
| Date: | 2009 - 2010 |
| Title: | Functional validation of mutant KLF4 protein |
| Funding Source: | Lockton fund for pancreatic cancer research |
| Role: | PI |
| ID: | Lockton fund grant |
| Date: | 2009 - 2011 |
| Title: | Molecular basis of pancreatic cancer progression and metastasis |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | R21CA129956 |
| Date: | 2008 - 2013 |
| Title: | KLF4 Genetic and Epigenetic Changes in Human Pancreatic Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1R01CA129956-01A1 |
| Date: | 2006 - 2009 |
| Title: | Genetic alterations of KLF4 in human pancreatic cancer |
| Funding Source: | NIH/NCI |
| Role: | PI |
| ID: | 1R03CA124523-01 |
| Date: | 2006 - 2009 |
| Title: | The role of KLF4a in pancreatic cancer |
| Funding Source: | American Association for Cancer Research (AACR) |
| Role: | PI |
| Date: | 2002 - 2007 |
| Title: | Antitumor Activity of Inducible Nitric Oxide Synthase |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | R01CA093829 |
Selected Publications
Peer-Reviewed Articles
- Xu, T, Chakraborty Patra, S, Wei, D, Tran, M, Rhea, R, Wei, B, Nguyen, P, Gagea Iurascu, M, Xie, X, Wu, Lr, Cohen, L, Liao, Z, Yang, P. Evaluation of the protective effect of Compound Kushen Injection against radiation‑induced lung injury in mice. Molecular medicine reports 31(4), 2025. e-Pub 2025. PMID: 39917996.
- Zuo X, Kiyasu Y, Liu Y, Deguchi Y, Liu F, Moussalli M, Tan L, Wei B, Wei D, Yang P, Shureiqi I. Colorectal ALOX15 as a host factor determining the effects of EPA and DHA on colorectal tumorigenesis in mice. Cellular and Molecular Gastroenterology and Hepatology 19(12), 2025. e-Pub 2025. PMID: 40818741.
- Cohen, L, Delorme, A, Cusimano, A, Chakraborty Patra, S, Nguyen, P, Deng, D, Iqbal, S, Nelson, M, Wei, D, Fields, C, Yang, P. Examining the effects of biofield therapy through simultaneous assessment of electrophysiological and cellular outcomes. Scientific reports 14(1), 2024. e-Pub 2024. PMID: 39622875.
- Chakraborty S, Wei D, Tran M, Lang FF, Newman RA, Yang P. PBI-05204, a supercritical CO2 extract of Nerium oleander, suppresses glioblastoma stem cells by inhibiting GRP78 and inducing programmed necroptotic cell death. Neoplasia 54:101008, 2024. e-Pub 2024. PMID: 38823209.
- Fields, C, Cohen, L, Cusimano, A, Chakraborty Patra, S, Nguyen, P, Deng, D, Iqbal, S, Nelson, M, Wei, D, Delorme, A, Yang, P. Search for Entanglement between Spatially Separated Living Systems. Biophysica 4(2):168-181, 2024. e-Pub 2024.
- Fields C, Cohen L, Cusimano A, Chakraborty S, Nguyen P, Deng D, Iqbal S, Nelson M, Wei D, Delorme A, Yang AP. Search for Entanglement between Spatially Separated Living Systems: Experiment Design, Results, and Lessons Learned. Biophysica 4(2):168-181, 2024. e-Pub 2024.
- Liu Y, Wei D, Deguchi Y, Xu W, Tian R, Liu F, Xu M, Mao F, Li D, Chen W, Valentin LA, Deguchi E, Yao JC, Shureiqi I, Zuo X. PPARδ dysregulation of CCL20/CCR6 axis promotes gastric adenocarcinoma carcinogenesis by remodeling gastric tumor microenvironment. Gastric Cancer 26(6):904-917, 2023. e-Pub 2023. PMID: 37572185.
- Wei D, Wang L, Liu Y, Hafley MA, Tan L, Lorenzi PL, Yang P, Zuo X, Bresalier RS. Activation of Vitamin D/VDR Signaling Reverses Gemcitabine Resistance of Pancreatic Cancer Cells Through Inhibition of MUC1 Expression. Dig Dis Sci 68(7):3043-3058, 2023. e-Pub 2023. PMID: 37071246.
- Wei D, Chen D, Mou H, Chakraborty S, Wei B, Tan L, Lorenzi PL, Qian X, Yang P. Targeting Glutamine Metabolism with a Novel Na+/K+-ATPase Inhibitor RX108 in Hepatocellular Carcinoma. Mol Cancer Ther 22(6):693-705, 2023. e-Pub 2023. PMID: 36780187.
- Liu Y, Deguchi Y, Wei D, Liu F, Moussalli MJ, Deguchi E, Li D, Wang H, Valentin LA, Colby JK, Wang J, Zheng X, Ying H, Gagea M, Ji B, Shi J, Yao JC, Zuo X, Shureiqi I. Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ. Nat Commun 13(1):2665, 2022. e-Pub 2022. PMID: 35562376.
- Al-Hassan JM, Wei D, Chakraborty S, Conway T, Rhea P, Wei B, Tran M, Gagea M, Afzal M, Oommen S, Nair D, Paul BM, Yang P. Fraction B From Catfish Epidermal Secretions Kills Pancreatic Cancer Cells, Inhibits CD44 Expression and Stemness, and Alters Cancer Cell Metabolism. Front Pharmacol 12:659590, 2021. e-Pub 2021. PMID: 34349642.
- Wang L, Jia Z, Xie D, Zhao T, Tan Z, Zhang S, Kong F, Wei D, Xie K. Methylation of HSP70 Orchestrates Its Binding to and Stabilization of BCL2 mRNA and Renders Pancreatic Cancer Cells Resistant to Therapeutics. Cancer Res 80(20):4500-4513, 2020. e-Pub 2020. PMID: 32699135.
- Liu F, Zuo X, Liu Y, Deguchi Y, Moussalli MJ, Chen W, Yang P, Wei B, Tan L, Lorenzi PL, Gao S, Jaoude JC, Mehdizadeh A, Valentin LA, Wei D, Shureiqi I. Suppression of Membranous LRP5 Recycling, Wnt/β-Catenin Signaling, and Colon Carcinogenesis by 15-LOX-1 Peroxidation of Linoleic Acid in PI3P. Cell Rep 32(7):108049, 2020. e-Pub 2020. PMID: 32814052.
- Zuo X, Deguchi Y, Xu W, Liu Y, Li HS, Wei D, Tian R, Chen W, Xu M, Yang Y, Gao S, Jaoude JC, Liu F, Chrieki SP, Moussalli MJ, Gagea M, Sebastian MM, Zheng X, Tan D, Broaddus R, Wang J, Ajami NJ, Swennes AG, Watowich SS, Shureiqi I. PPARD and Interferon Gamma Promote Transformation of Gastric Progenitor Cells and Tumorigenesis in Mice. Gastroenterology 157(1):163-178, 2019. e-Pub 2019. PMID: 30885780.
- Liu Y, Deguchi Y, Tian R, Wei D, Wu L, Chen W, Xu W, Xu M, Liu F, Gao S, Jaoude JC, Chrieki SP, Moussalli MJ, Gagea M, Morris J, Broaddus RR, Zuo X, Shureiqi I. Pleiotropic Effects of PPARD Accelerate Colorectal Tumorigenesis, Progression, and Invasion. Cancer Res 79(5):954-969, 2019. e-Pub 2019. PMID: 30679176.
- Wang L, Shen F, Stroehlein JR, Wei D. Context-dependent functions of KLF4 in cancers: could alternative splicing isoforms be the key?. Cancer Letters 438:10-16, 2018. e-Pub 2018. PMID: 30217565.
- Xie VK, Li Z, Yan Y, Jia Z, Zuo X, Ju Z, Wang J, Du J, Xie D, Xie K, Wei D. DNA-methyltransferase 1 Induces Dedifferentiation of Pancreatic Cancer Cells through Silencing of Krüppel-like factor 4 Expression. Clin Cancer Res 23(18):5585-5597, 2017. e-Pub 2017. PMID: 28659310.
- Guo K, Cui J, Quan M, Xie D, Jia Z, Wei D, Wang L, Gao Y, Ma Q, Xie K. The Novel KLF4/MSI2 Signaling Pathway Regulates Growth and Metastasis of Pancreatic Cancer. Clin Cancer Res 23(3):687-696, 2017. e-Pub 2017. PMID: 27449499.
- Zuo X, Xu W, Xu M, Tian R, Moussalli MJ, Mao F, Zheng X, Wang J, Morris JS, Gagea M, Eng C, Kopetz S, Maru DM, Rashid A, Broaddus R, Wei D, Hung MC, Sood AK, Shureiqi I. Metastasis regulation by PPARD expression in cancer cells. JCI Insight 2(1):e91419, 2017. e-Pub 2017. PMID: 28097239.
- Yan Y, Li Z, Kong X, Jia Z, Zuo X, Gagea M, Huang S, Wei D, Xie K. KLF4-mediated Suppression of CD44 Signaling Negatively Impacts Pancreatic Cancer Stemness and Metastasis. Cancer Res, 2016. e-Pub 2016. PMID: 26880805.
- Wei D, Wang L, Yan Y, Jia Z, Gagea M, Li Z, Zuo X, Kong X, Huang S, Xie K. KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis. Cancer Cell 29(3):324-338, 2016. e-Pub 2016. PMID: 26977883.
- Sun H, Tang H, Xie D, Jia Z, Ma Z, Wei D, Mishra L, Gao Y, Zheng S, Xie K, Peng Z. Krüppel-like Factor 4 Blocks Hepatocellular Carcinoma Dedifferentiation and Progression through Activation of Hepatocyte Nuclear Factor-6. Clin Cancer Res 22(2):502-12, 2016. e-Pub 2016. PMID: 26338995.
- Quan M, Cui J, Xia T, Jia Z, Xie D, Wei D, Huang S, Huang Q, Zheng S, Xie K. Merlin/NF2 Suppresses Pancreatic Tumor Growth and Metastasis by Attenuating the FOXM1-Mediated Wnt/β-Catenin Signaling. Cancer Res 75(22):4778-89, 2015. e-Pub 2015. PMID: 26483206.
- Li Z, Jia Z, Gao Y, Xie D, Wei D, Cui J, Mishra L, Huang S, Zhang Y, Xie K. Activation of vitamin D receptor signaling downregulates the expression of nuclear FOXM1 protein and suppresses pancreatic cancer cell stemness. Clin Cancer Res 21(4):844-53, 2015. e-Pub 2015. PMID: 25501129.
- Shi M, Cui J, Du J, Wei D, Jia Z, Zhang J, Zhu Z, Gao Y, Xie K. A novel KLF4/LDHA signaling pathway regulates aerobic glycolysis in and progression of pancreatic cancer. Clin Cancer Res 20(16):4370-80, 2014. e-Pub 2014. PMID: 24947925.
- Li L, Li Z, Kong X, Xie D, Jia Z, Jiang W, Cui J, Du Y, Wei D, Huang S, Xie K. Down-Regulation of MicroRNA 494 via Loss of SMAD4 Increases FOXM1 and β-Catenin. Gastroenterology 147(2):485-97.e18, 2014. e-Pub 2014. PMID: 24859161.
- Cui J, Shi M, Xie D, Wei D, Jia Z, Zheng S, Gao Y, Huang S, Xie K. FOXM1 promotes the warburg effect and pancreatic cancer progression via transactivation of LDHA expression. Clin Cancer Res 20(10):2595-606, 2014. e-Pub 2014. PMID: 24634381.
- Li Q, Gao Y, Jia Z, Mishra L, Guo K, Li Z, Le X, Wei D, Huang S, Xie K. Dysregulated Krüppel-like factor 4 and vitamin D receptor signaling contribute to progression of hepatocellular carcinoma. Gastroenterology 143(3):799-810.e1-2, 2012. e-Pub 2012. PMID: 22677193.
- Li Q, Jia Z, Wang L, Kong X, Li Q, Guo K, Tan D, Le X, Wei D, Huang S, Mishra L, Xie K. Disruption of Klf4 in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in mice. Gastroenterology 142(3):531-542, 2012. e-Pub 2012. PMID: 22155367.
- Huang C, Qiu Z, Wang L, Peng Z, Jia Z, Logsdon CD, Le X, Wei D, Huang S, Xie K. A novel FoxM1-caveolin signaling pathway promotes pancreatic cancer invasion and metastasis. Cancer Research 72(3):655-665, 2012. e-Pub 2012. PMID: 22194465.
- Gao Y, Jia Z, Kong X, Li Q, Chang DZ, Wei D, Le X, Suyun H, Huang S, Wang L, Xie K. Combining betulinic acid and mithramycin A effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis. Cancer Res 71(15):5182-93, 2011. e-Pub 2011. PMID: 21673052.
- Wei D, Wang L, Kanai M, Jia Z, Le X, Li Q, Wang H, Xie K. KLF4a Up-regulation Promotes Cell Cycle Progression and Reduces Survival Time of Patients with Pancreatic Cancer. Gastroenterology 139(6):2135-45, 2010. e-Pub 2010. PMID: 20727893.
- Jia Z, Gao Y, Wang L, Li Q, Zhang J, Le X, Wei D, Yao JC, Chang DZ, Huang S, Xie K. Combined treatment of pancreatic cancer with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic antitumor activity. Cancer Res 70(3):1111-9, 2010. e-Pub 2010. PMID: 20086170.
- Li Q, Wei D, Wang L, Wang L, Jia Z, Le X, Gao Y, Huang S, Xie K. Modeling liver metastasis using a tumor cell line derived from an enhanced green fluorescent protein transgenic mouse. Clin Exp Metastasis 27(1):11-8, 2010. e-Pub 2010. PMID: 19882218.
- Li Q, Zhang N, Jia Z, Le X, Dai B, Wei D, Huang S, Tan D, Xie K. Critical role and regulation of transcription factor FoxM1 in human gastric cancer angiogenesis and progression. Cancer Res 69(8):3501-9, 2009. e-Pub 2009. PMID: 19351851.
- Peng Z, Tang H, Wang X, Zhou C, Fan J, Wang L, Jia Z, Li Q, Le X, Wei D, Xie K. Inhibition of the growth and metastasis of human colon cancer by restoration of RUNX3 expression in cancer cells. Int J Oncol 33(5):979-84, 2008. e-Pub 2008. PMID: 18949360.
- Wang L, Guan X, Zhang J, Jia Z, Wei D, Li Q, Yao J, Xie K. Targeted inhibition of Sp1-mediated transcription for antiangiogenic therapy of metastatic human gastric cancer in orthotopic nude mouse models. Int J Oncol 33(1):161-7, 2008. e-Pub 2008. PMID: 18575762.
- Wei D, Kanai M, Jia Z, Le X, Xie K. Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells. Cancer Res 68(12):4631-9, 2008. e-Pub 2008. PMID: 18559508.
- Jia Z, Zhang J, Wei D, Wang L, Yuan P, Le X, Li Q, Yao J, Xie K. Molecular basis of the synergistic antiangiogenic activity of bevacizumab and mithramycin A. Cancer Res 67(10):4878-85, 2007. e-Pub 2007. PMID: 17510417.
- Kanai M, Wei D, Li Q, Jia Z, Ajani J, Le X, Yao J, Xie K. Loss of Kruppel-like factor 4 expression contributes to Sp1 overexpression and human gastric cancer development and progression. Clin Cancer Res 12(21):6395-402, 2006. e-Pub 2006. PMID: 17085651.
- Zhang J, Jiang Y, Jia Z, Li Q, Gong W, Wang L, Wei D, Yao J, Fang S, Xie K. Association of elevated GRP78 expression with increased lymph node metastasis and poor prognosis in patients with gastric cancer. Clin Exp Metastasis 23(7-8):401-10, 2006. e-Pub 2006. PMID: 17187227.
- Gong W, Jiang Y, Wang L, Wei D, Yao J, Huang S, Fang S, Xie K. Expression of autocrine motility factor correlates with the angiogenic phenotype of and poor prognosis for human gastric cancer. Clin Cancer Res 11(16):5778-83, 2005. e-Pub 2005. PMID: 16115916.
- Wei D, Gong W, Oh SC, Li Q, Kim WD, Wang L, Le X, Yao J, Wu TT, Huang S, Xie K. Loss of RUNX3 expression significantly affects the clinical outcome of gastric cancer patients and its restoration causes drastic suppression of tumor growth and metastasis. Cancer Res 65(11):4809-16, 2005. e-Pub 2005. PMID: 15930301.
- Le X, Wei D, Huang S, Lancaster JR, Xie K. Nitric oxide synthase II suppresses the growth and metastasis of human cancer regardless of its up-regulation of protumor factors. Proc Natl Acad Sci U S A 102(24):8758-63, 2005. e-Pub 2005. PMID: 15939886.
- Wei D, Gong W, Kanai M, Schlunk C, Wang L, Yao JC, Wu TT, Huang S, Xie K. Drastic down-regulation of Kruppel-like factor 4 expression is critical in human gastric cancer development and progression. Cancer Res 65(7):2746-54, 2005. e-Pub 2005. PMID: 15805274.
- Gong W, Wang L, Yao JC, Ajani JA, Wei D, Aldape KD, Xie K, Sawaya R, Huang S. Expression of activated signal transducer and activator of transcription 3 predicts expression of vascular endothelial growth factor in and angiogenic phenotype of human gastric cancer. Clin Cancer Res 11(4):1386-93, 2005. e-Pub 2005. PMID: 15746037.
- Wei D, Gong W, Kanai M, Schlunk C, Wang L, Yao JC, Wu TT, Huang S, Xie K. Drastic down-regulation of Kruppel-like factor 4 expression is critical in human gastric cancer development and progression. Cancer Res 65(7):2746-54, 2005. e-Pub 2005.
- Wei D, Gong W, Oh SC, Li Q, Kim WD, Wang L, Le X, Yao J, Wu TT, Huang S, Xie K. Loss of RUNX3 expression significantly affects the clinical outcome of gastric cancer patients and its restoration causes drastic suppression of tumor growth and metastasis. Cancer Res 102(24):8758-63, 2005. e-Pub 2005.
- Wang L, Shi G, Yao JC, Gong W, Wei D, Wu TT, Ajani JA, Huang S, Xie K. Expression of endothelial nitric oxide synthase correlates with the angiogenic phenotype of and predicts poor prognosis in human gastric cancer. Gastric Cancer 8(1):18-28, 2005. e-Pub 2005. PMID: 15747170.
- Yao JC, Wang L, Wei D, Gong W, Hassan M, Wu TT, Mansfield P, Ajani J, Xie K. Association between expression of transcription factor Sp1 and increased vascular endothelial growth factor expression, advanced stage, and poor survival in patients with resected gastric cancer. Clin Cancer Res 10(12 Pt 1):4109-17, 2004. e-Pub 2004. PMID: 15217947.
- Xie TX, Wei D, Liu M, Gao AC, Ali-Osman F, Sawaya R, Huang S. Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene 23(20):3550-3560, 2004. e-Pub 2004. PMID: 15116091.
- Jiang Y, Wang L, Gong W, Wei D, Le X, Yao J, Ajani J, Abbruzzese JL, Huang S, Xie K. A high expression level of insulin-like growth factor I receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric cancer. Clin Exp Metastasis 21(8):755-64, 2004. e-Pub 2004. PMID: 16035620.
- Peng Z, Zhang F, Zhou C, Ling Y, Bai S, Liu W, Qiu G, He L, Wang L, Wei D, Lin E, Xie K. Genome-Wide Search for Loss of Heterozygosity in Chinese Patients with Sporadic Colorectal Cancer. Int J Gastrointest Cancer 34(1):39-48, 2004. e-Pub 2004.
- Wei D, Wang L, He Y, Xiong HQ, Abbruzzese JL, Xie K. Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity. Cancer Res 64(6):2030-2038, 2004. e-Pub 2004. PMID: 15026340.
- Wang L, Wei D, Huang S, Peng Z, Le X, Wu TT, Yao J, Ajani J, Xie K. Transcription factor Sp1 expression is a significant predictor of survival in human gastric cancer. Clin Cancer Res 9(17):6371-80, 2003. e-Pub 2003. PMID: 14695137.
- Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K. Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. Oncogene 22(3):319-329, 2003. e-Pub 2003. PMID: 12545153.
- Wang B, Wei D, Crum VE, Richardson EL, Xiong HQ, Luo Y, Huang S, Abbruzzese JL, Xie K. A novel model system for studying the double-edged roles of nitric oxide production in pancreatic cancer growth and metastasis. Oncogene 22(12):1771-1782, 2003. e-Pub 2003. PMID: 12660813.
- Yang S, Wei D, Wang D, Phimphilai M, Kerbsbach P, Francesch R. In vitro and in vivo synergetic interaction between the Runx2/Cbfa1 transcription factor and bone morphogenetic protein 2 in stimulating osteoblast differentiation. Journal of Bone and Mineral Research 18(4):705-715, 2003. e-Pub 2003.
- Wei D, Richardson EL, Zhu K, Wang L, Le X, He Y, Huang S, Xie K. Direct demonstration of negative regulation of tumor growth and metastasis by host-inducible nitric oxide synthase. Cancer Res 63(14):3855-3859, 2003. e-Pub 2003. PMID: 12873972.
- Le X, Wei D, Abbruzzese JL, Xie K. Adenovirus-mediated Nitric Oxide Synthase II Gene Transfer Upregulates Multiple Angiogenic Molecules by Fails to Promote the Growth and Metastasis in Human Cance. Gastrointestinal Cancer Research Conference 2002. Orlando, Florida, 2002. e-Pub 2002.
- Zhang Y, Wei D, Xu S, Zhang X, Jiang S. Photo flux measurement of the soft X-ray beamline in Hefei light source. . Nuclear Techniques 24(7):529-534, 2001. e-Pub 2001.
- Wei D, Dai B, Chen S, Wang Z. The expression of adenoviral mediated gfp reporter gene in tumor cells induced and regulated by irradiation. Acta Biochemical et Biophysica Sinica 33(1):123-127, 2001. e-Pub 2001.
- Wei D, Dai B, Wang Z, Chen S. Adenovirus mediated IL-12 gene therapy in combination with radiotherapy for murine liver cancer. Chinese Journal of Radiological Medicine and Protection 21(4):279-281, 2001. e-Pub 2001.
- Zhang X, Xu S, Zhang Y, Wang Y, Wang M, Zhang X, Zhang Z, Wei D. Radiobiological effects of soft X-ray with resonance energy of carbon k-absorption edge from synchrotron radiation on plasmid pBK-CMV. Chinese Journal of Radiological Medicine and Protection 21(5):321-324, 2001. e-Pub 2001.
- Wei D, Dai B, Chen S. Tumor targeted expression of adenovirus mediated CDglyTK gene regulated by irradiation via Egr-1 promoter. National Medical Journal of China 81(16):999-1003, 2001. e-Pub 2001.
- Sun W, Tang Y, Wei D, Tang Z, Chen S. Combined gene therapy for liver cancer with IL-18 gene and cytosine deaminase gene. Chinese Journal of Hepatology 9(5):300-302, 2001. e-Pub 2001.
- Wei D, Chen S, Wang Z. Cloning the promoter of mouse Egr-1 gene and study on its property of radiation inducibility of gene expression. China Oncology 10(4):326-329, 2000. e-Pub 2000.
- Wei D, Mi J, Chen S. High efficient generation of recombinant adenovirus containing double suicide gene CDglyTK by using a method of recombination in bacteria. Chinese Journal of Cancer Biotherapy 19(5):399-403, 2000. e-Pub 2000.
- Wei D, Tang Z, Chen S. Construction of recombinant adenoviral vector containing mIL-12 using the method of homogenous recombination in bacteria and its expression in vitro with high efficiency. Chinese Journal of Biochemistry and Molecular Biology 16(6):716-721, 2000. e-Pub 2000.
- Zhang J, Wei D, Chen S. Combination gene therapy for hepatoma with IL-2 gene and INF-g gene by transduction. Chinese Journal of Microbiology and Immunology 20(3), 2000. e-Pub 2000.
- Sun W, Wei D, Tang Z, Chen S. Gene therapy for murine liver cancer by adenovirus mediated cytosine deaminase gene. Chinese Journal of Hepatology 8(5):282-284, 2000. e-Pub 2000.
- Zhang X, Xu S, Zhang Z, Wei D. Advances in radiobiological effects of soft X-ray from synchrotron radiation. Foreign Medicine, Section of Radiological Medicine and Nuclear Medicine 23(1):40-43, 1999. e-Pub 1999.
- Wei D, Chen S. Advances in the malignant tumor gene therapy combined with radiotherapy. Chinese Journal of Cancer Biotherapy 6(2):149-251, 1999. e-Pub 1999.
- Wei D, Jin A, Huang G, Wang S, Zuo X. The mechanism of low dose radiation influencing B16 melanoma blood-borne pulmonary metastases. Journal of Radiation Research and Radiation Processing 14(2):101-104, 1996. e-Pub 1996.
- Wei D, Jin A, Huang G, Wang S, Zuo X. The influence of low dose X-ray whole body irradiation given before or after tumor implantation on tumor growth and metastases in mice. Chinese Journal of Radiology 1:49-51, 1996. e-Pub 1996.
- Wei D, Jin A, Wang S, Huang G, Zuo X. The enhancing effect of 75mGy X-ray whole body irradiation on splenocyte's anti-tumor ability of mice. Chinese Journal of Immunology 12(4):234-235, 1996. e-Pub 1996.
- Wei D, Huang G, JinA, Wang S, Zuo X. The anti-metastasis effect of low dose total body irradiation on mice with variable tumor bearing time. Chinese Journal of Clinical Oncology 23(1):5-54, 1996. e-Pub 1996.
Invited Articles
- Liu Y, Colby JK, Zuo X, Jaoude J, Wei D, Shureiqi I. The Role of PPAR-δ in Metabolism, Inflammation, and Cancer: Many Characters of a Critical Transcription Factor. Int J Mol Sci 19(11), 2018. e-Pub 2018. PMID: 30373124.
- Xie K, Wei D, Huang S. Transcriptional anti-angiogenesis therapy of human pancreatic cancer. Cytokine Growth Factor Rev 17(3):147-56, 2006. e-Pub 2006. PMID: 16516532.
- Xie K, Wei D, Shi Q, Huang S. Constitutive and inducible expression and regulation of vascular endothelial growth factor. Cytokine Growth Factor Rev 15(5):297-324, 2004. e-Pub 2004. PMID: 15450248.
- WeiD, Xiong HQ, Abbruzzese JL, Xie K. Experimental Animal models of Pancreatic Cancer Carcinogenesis and Metastasis. International Journal of Gastrointestinal Cancer 33(1):43-60, 2003. e-Pub 2003. PMID: 12909737.
Review Articles
- Wei D, Wang L, Liu Y, Zuo X, Shen X, S Bresalier AR. CAR-Macrophage Cell Therapy: A New Era of Hope for Pancreatic Cancer. Clinical Cancer Res 31(19):4018-4031, 2025. e-Pub 2025. PMID: 40757874.
- Chiriva-Internati M, Grizzi F, Monari MN, Taverna G, Figueroa JA, Wei D, Bresalier BS. Immunomodulatory role of vitamin D and emerging immunotherapies in hepatocellular carcinoma. Front Nutr 12, 2025. e-Pub 2025. PMID: 41041128.
- Wei D, Wang L, Zuo X, Maitra A, Bresalier RS. A Small Molecule with Big Impact: MRTX1133 Targets the KRASG12D Mutation in Pancreatic Cancer. Clin Cancer Res 30(4):655-662, 2024. e-Pub 2024. PMID: 37831007.
- Wei D, Wang L, Zuo X, Bresalier RS. Vitamin D: Promises on the Horizon and Challenges Ahead for Fighting Pancreatic Cancer. Cancers (Basel) 13(11), 2021. e-Pub 2021. PMID: 34072725.
- Yan Y, Zuo X, Wei D. Emerging Role of CD44 in Cancer Stem Cells: A Promising Biomarker and Therapeutic Target. Stem Cells Transl Med 4(9):1033-43, 2015. e-Pub 2015. PMID: 26136504.
- Wei D, Kanai M, Huang S, Xie K. Emerging role of KLF4 in human gastrointestinal cancer. Carcinogenesis 27(1):23-31, 2006. e-Pub 2006. PMID: 16219632.
- Wei D, Xiong HQ, Abbruzzese JL, Xie K. Experimental animal models of pancreatic carcinogenesis and metastasis. Int J Gastrointest Cancer 33(1):43-60, 2003. e-Pub 2003. PMID: 12909737.
Other Articles
- Wei D, Lin X, Bresalier RS Reframing cancer cachexia: the vagal brain-liver axis as a novel neuro-metabolic target. Signal Transduct Target Ther 10(1), 2025. PMID: 41219223.
Editorials
- Wang L, Shureiqi I, Stroehlein JR, Wei D. Novel and emerging innate immune therapeutic targets for pancreatic cancer. Expert Opin Ther Targets 22(12):977-981, 2018. PMID: 30332892.
- Yan Y, Wei D. The CRISPR-Cas9 System: A Powerful Tool for Genome Engineering and Regulation. Adv Genet Eng(2):e103, 2013.
Abstracts
- Yang P, Yang P, Chakraborty S, Nguyen P, Deng D, Cusimano A, Wei D, Cohen L. Biofield therapy suppressed invasion and metastases of human pancreatic cancer. Cancer Res 84(6_Supplement):4128, 2024. e-Pub 2024.
- Liu Y, Wei D, Wang L, Yao JC, Shureiqi I, Zuo X. PPARδ promotes gastric adenocarcinoma carcinogenesis by enhancing ZBP1-induced necroptosis and inflammation and fostering gastric tumor immunosuppressive microenvironment. Cancer Res 84((6_Supplement):3038, 2024. e-Pub 2024.
- Wei D, Hafley M, Wang L, Liu Y, Yang P, Zuo X, Bresalier RS. Activation of vitamin D/VDR signaling reverses gemcitabine resistance of pancreatic cancer cells through inhibition of MUC1 expression. Cancer Res 82(12_Supplement):6367, 2022. e-Pub 2022.
- Yang P, Chakraborty S, Nguyen P, Cui M, Cusimano A, Wei D, Prinsloo S, Cohen L. Biofield therapy suppressed the growth of human pancreatic cancer cells by modulation of cell cycle and cell voltage potentials. Cancer Res 82(12_Supplement):5382, 2022. e-Pub 2022.
- Wei D, Kanai M, Le RX, Jia Z, Wang H, Evans DB, and Xie K. Altered expression of KLF4a promotes cell cycle progression and is associated with worse prognosis in patients with pancreatic ductal adenocarcinoma. Proc. Am. Assoc. Cancer Res. Abstract # 2472, 2009. e-Pub 2009.
- Wei D, Yuan P, Jia Z, Zhang J, Le X, Qiang L, Wang L, Xie K. Identification and validation of Sp1 as a critical regulator of angiogenesis in human pancreatic cancer by coupling gene knockdown and cDNA microarray Analyses. Proc. Am. Assoc. Cancer Res. Abstract #6549, 2008. e-Pub 2008.
- Wei D, Xie K. KLF4 up-regulates p27Kip1 expression and inhibits the growth and and metastasis of pancreatic cancer. Proc. Am. Assoc. Cancer Res. #1249, 2007. e-Pub 2007.
- Wei D, Li Q, Oh SC, Abbruzzese JL, Xie K. Negative regulation of Sp1 by p53 in human cancer. Proc. Am. Assoc. Cancer Res. #4600. Anaheim, CA, 2005. e-Pub 2005.
- Wei D, Wang L, Zhu K, He Y, Xiong HQ, Abbruzzese JL, Xie K. Celecoxib inhibits vascular endothelial growth factor expression by targeting Sp1 transcription factor and reduces human pancreatic cancer angiogenesis and metastasis. Proc. Am. Assoc. Cancer Res. #R2774. Washington, DC, 2003. e-Pub 2003.
- Crum VE, Wei D, Wang L, Le X, Zheng L, Abbruzzese JL, Xie K. Role and regulation of endothelial nitric oxide synthase gene expression by STAT3 in human pancreatic cancer. Proc. Am. Assoc. Cancer Res. #5069. Washington, DC, 2003. e-Pub 2003.
- Wang L, Zheng L, Wei D, Le X, Peng Z, Wu TT, Yao J, Ajani J, Xie K. Unique expression patterns of transcription factor Sp1 in normal and malignant gastric tissues: Implication of its role in gastric cancer development and progression. Proc. Am. Assoc. Cancer Res. #4450. Washington, DC, 2003. e-Pub 2003.
- Wei D, Wang B, Wang L, Abbruzzese JL, Xie K. Reciprocal Regulation of Interferon-g and Inducible Nitric Oxide Synthase Expression: Its Implication in Tumor Progression. Gastrointestinal Cancer Research Conference 2002. Orlando, Florida, 2002. e-Pub 2002.
- Wei D, He Y, Le X, Abbruzzese JL, Xie K. Negative Regulation of Tumor Growth and Metastasis by Host Nitric Oxide Synthase 2 (NOS2): A Direct Proof. Proc. Am. Assoc. Cancer Res. # LB-74. San Francisco, California, 2002. e-Pub 2002.
- Wang B, Wei D, Abbruzzese JL, He Y, Xie K. Experimental therapy of pancreatic adenocarcinoma by adenovirus-mediated transfer of the inducible nitric oxide synthase gene. . AACR Special Conference on Molecular Biology and New Therapeutic Strategies. #490, Miami Beach, Florida, 2001. e-Pub 2001.
- Wei D, Yang S, Wang D, Franceschi R. Adenovirus-mediated expression of Cbfa1/Runx2 in C3H10T1/2 mesenchymal cells induces mineralization and expression of some, but not all osteoblast markers. ASBMR 23rd Annual Meeting. #M223, Phoenix, Arizona, 2001. e-Pub 2001.
- Wei D, Tang Z, Chen S. Adenovirus mediated interleukin 12 gene-radiotherapy for the treatment of murine liver cance. 15th FAOBMB Symposium: Perspectives of Biochemistry and Molecular Biology in the 21 Century. # SC-11, Beijing, China, 2000. e-Pub 2000.
- Wei D, Dai B, Chen S. Tumor targeted expression of adenovirus mediated CDglyTK gene regulated by irradiation for the treatment of murine liver cancer. 15th FAOBMB Symposium: Perspectives of Biochemistry and Molecular Biology in the 21 Century. # PC-21, Beijing, China, 2000. e-Pub 2000.
- Wei, D, Chen S, Wang Z. Cloning the promoter of mouse Egr-1 gene and study on its property of radiation inducibility of gene expression. 15th FAOBMB Symposium: Perspectives of Biochemistry and Molecular Biology in the 21 Century. # PC-22, Beijing, China, 2000. e-Pub 2000.
- Wei D, Le X, Zheng L, Abbruzzese JL, Xie K. Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. The Lustgarten Foundation for Pancreatic Cancer Research: Translating Discovery to Patient Care, Houston, Texas, 2000. e-Pub 2000.
Book Chapters
- Wang L, Xie D, Wei D. Pancreatic Acinar-to-Ductal Metaplasia and Pancreatic Cancer. In: Pancreatic Cancer. Springer Nature, 299-308, 2019.
- Wang L, Zuo X, Xie K, Wei D. The Role of CD44 and Cancer Stem Cells. In: Cancer Stem Cells. Springer Protocols, 31-42, 2018.
Letters to the Editor
- Zuo X, Wang L, Liu Y, Wang H, Hafley M, Gagea M, Chen R, Xiong Y, Pan S, Shureiqi I, Bresalier RS, Wei D. Dysregulated KLF4 expression plays a pivotal role in the pathogenesis of pancreatic intraductal papillary mucinous neoplasms. Gut 74: 327-329, 2025.
Patient Reviews
CV information above last modified July 22, 2026