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David J. Tweardy, MD

Department of Infectious Diseases, Infection Control, and Employee Health, Division of Internal Medicine

Meet David Tweardy, M.D.

Present Title & Affiliation

Primary Appointment

Robert A. Welch Distinguished University Chair in Chemistry, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas

Full Member, The University of Texas MD Anderson Cancer Center Graduate School of Biomedical Sciences, Houston, TX

Professor with Tenure, Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX

Professor with Tenure (Joint Appointment), Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Head, Department of Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Adjunct Professor, Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX

Dual/Joint/Adjunct Appointment

Full Member, The University of Texas MD Anderson Cancer Center Graduate School of Biomedical Sciences, Houston, TX

Professor with tenure, Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX

Professor with tenure, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Adjunct Professor, Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX

Adjunct Professor, Department of National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas

Education & Training

Degree-Granting Education

1978	Harvard Medical School, Boston, Massachusetts, US, MD
1974	Princeton University, Princeton, New Jersey, US, Chemistry, AB, cum laude

Postgraduate Training

1986-1986	Research Associate, Molecular Hematology, The Wistar Institute, Philadelphia, Pennsylvania
1984-1986	Associate Scientist, Molecular Hematology, The Wistar Institute, Philadelphia, Pennsylvania
1983-1984	Research Associate, Infectious Diseases, Case Western Reserve University, Cleveland, Ohio
1982-1983	Chief Resident, Medicine, Case Western Reserve University, Cleveland, Ohio
1980-1982	Clinical Fellowship, Infectious Diseases, Case Western Reserve University, Cleveland, Ohio
1979-1980	Clinical Residency, Medicine, Case Western Reserve University, Cleveland, Ohio
1978-1979	Clinical Internship, Medicine, Case Western Reserve University, Cleveland, Ohio

Licenses & Certifications

1999	Texas Medical License
1984	American Board of Infectious Diseases, Lifetime Certification
1983	American Board of Internal Medicine, Lifetime Certification
1978	Drug Enforcement Administration (DEA)

Experience & Service

Faculty Academic Appointments

Dallas/Fort Worth Living Legend Chair for Cancer Research III, Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, 2015 - 2023

Professor, Department of Biochemistry & Molecular Biology, Baylor College of Medicine, Houston, TX, 2012 - 2014

Endowed Chair in Medicine, MD Anderson Foundation, Baylor College of Medicine, Houston, TX, 2009 - 2014

Adjunct Professor, Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, 2008 - 2014

Professor, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, 2004 - 2014

Professor with tenure, Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX, 1999 - 2014

Associate Professor, Department of Molecular Genetics & Biochemistry, University of Pittsburgh, Pittsburgh, PA, 1993 - 1999

Associate Professor with tenure, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 1993 - 1999

Assistant Professor, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 1987 - 1992

Assistant Professor, Department of Molecular Genetics & Biochemistry, University of Pittsburgh, PIttsburgh, PA, 1987 - 1992

Administrative Appointments/Responsibilities

Chair ad interim, Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2016 - 2019

Chair ad interim, Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 2015 - 2016

Head, Department of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2014 - Present

Chief, Infectious Diseases Service, Texas Children's Hospital Pavilion for Women, Houston, TX, 2012 - 2014

Chair ad interim, Department of Medicine, Baylor College of Medicine, Houston, TX, 2007 - 2008

Interim Chief, Department of Section of Immunology, Allergy, & Rheumatology, Department of Medicine, Baylor College of Medicine, Houston, TX, 2006 - 2011

Deputy Chair, Department of Medicine, Baylor College of Medicine, Houston, TX, 2006 - 2007

Chief, Infectious Diseases Service, Ben Taub General Hospital, Harris County Health District, Houston, TX, 2006 - 2007

Chief, Department of Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, TX, 1999 - 2014

Interim Chief, Department of Medicine, University of Pittsburgh, PIttsburgh, PA, 1997 - 1999

Other Professional Positions

Member, Faculty of the Structural, Computational Biology, & Molecular Biophysics Graduate Program, Baylor College of Medicine, Houston, TX, 2012 - 2014

Member, Faculty of the National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, 2012 - 2014

Faculty Cabinet, Best Minds-Best Medicine Campaign, Baylor College of Medicine, Houston, TX, 2007 - 2008

Member, Leadership Institute Advisory Committee, Baylor College of Medicine, Houston, TX, 2007 - 2008

Co-Director, Personalized Medicine Alliance, Baylor College of Medicine, Houston, TX, 2007 - 2009

Chair, Faculty Appointments and Promotions Committee, Baylor College of Medicine, Houston, TX, 2007 - 2014

Associate Program Director, Allergy/Immunology Fellowship Training Program, Baylor College of Medicine, Houston, TX, 2006 - 2007

Co-Chairman, Antibiotic Subcommittee, Pharmacy and Therapeutics Committee, Harris County Health District, Houston, TX, 2006 - 2014

Member, Obstetrics & Gynecology Chair Search Committee, Baylor College of Medicine, Houston, TX, 2006 - 2007

Member, Faculty of the Graduate School of Biomedical Sciences, Baylor College of Medicine, Houston, TX, 2005 - 2014

Chair, Pulmonary/Critical Care Medicine Chief Search Committee, Department of Medicine, Baylor College of Medicine, Houston, TX, 2004 - 2006

Member, Resident and Fellow Scientific Development Committee, Department of Medicine, Baylor College of Medicine, Houston, TX, 2004 - 2008

Member, Department of Medicine Chao Award Selection Committee, Baylor College of Medicine, Houston, TX, 2003 - 2005

Member, Institutional Biosafety Committee, Baylor College of Medicine, Houston, TX, 2003 - 2004

Member, Faculty Awards Committee, Baylor College of Medicine, Houston, TX, 2003 - 2006

Member, Department of Medicine Faculty Appointments and Promotions Committee, Baylor College of Medicine, Houston, TX, 2001 - 2007

Chairman, Basic/Clinical Collaborative Research Program Coommittee, Baylor College of Medicine, Houston, TX, 2001

Member, Review Panel, Baylor Center for AIDS Research (CFAR) Development Awards, Baylor College of Medicine, Houston, TX, 2001

Member, Department of Medicine Task Force Committee on Incentives and Compensation, Baylor College of Medicine, Houston, TX, 2000

Staff Physician, Ben Taub General Hospital, Harris County Health District, Houston, TX, 1999 - 2014

Member, Department of Medicine Executive Faculty Committee, Baylor College of Medicine, Houston, TX, 1999 - 2014

Program Director, Infectious Diseases Fellowship Training Program, Baylor College of Medicine, Houston, TX, 1999 - 2002

Coordinator, United Way Campaign, Baylor College of Medicine, Houston, TX, 1999

Member, UPMC-Presbyterian Utilization Review Committee, University of Pittsburgh Medical Center, Pittsburgh, PA, 1998 - 1999

Member, Graduate Program in Biochemistry & Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, 1997 - 1999

Member, Curriculum Committee, Immunology Program, University of Pittsburgh School of Medicine, Pittsburgh, PA, 1996 - 1999

Member, Graduate Program in Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 1996 - 1999

Member, Standing Committee for Tenured Faculty Promotions and Appointments, University of Pittsburgh School of Medicine, Pittsburgh, PA, 1996 - 1997

Ad Hoc Reviewer, Subcommittee for Disclosure Review, Technology Transfer Committee, Office of Technology Transfer and Intellectual Property, University of Pittsburgh School of Medicine, Pittsburgh, PA, 1996 - 1999

Member, Integration of the Basic Science into the Clinical Years Task Force, University of Pittsburgh School of Medicine, Pittsburgh, PA, 1996

Member, Department of Medicine Intern Interview Committee, University of Pittsburgh School of Medicine, Pittsburgh, PA, 1995 - 1999

Member, Dean’s Medical School Applicant Interview Committee, University of Pittsburgh School of Medicine, Pittsburgh, PA, 1993 - 1999

Staff Physician, Montefiore-University Hospital, Pittsburgh, PA, 1991 - 1999

Member, Graduate Faculty, University of Pittsburgh, Pittsburgh, PA, 1987 - 1999

Associate Member and Full Member, Pittsburgh Cancer Institute, Pittsburgh, PA, 1987 - 1999

Staff Physician, Oakland Veterans Administration Hospital, Pittsburgh, PA, 1987 - 1999

Staff Physician, Presbyterian-University Hospital, Pittsburgh, PA, 1987 - 1999

Intern Selection Committee, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH, 1983 - 1984

Staff Physician, University Hospitals of Cleveland, Cleveland, OH, 1983 - 1986

Staff Physician, Cleveland Veterans Administration Hospital, Wade Park Division, Cleveland, OH, 1983 - 1986

Extramural Institutional Committee Activities

Member, Navigation Taskforce Subcommittee, The University of Texas MD Anderson Cancer Center, 2021 - Present

Member, Strategic Position Management Committee: Advanced Practice Providers, The University of Texas MD Anderson Cancer Center, 2020 - Present

Member, Strategic Position Management Committee: Research & Education Faculty, The University of Texas MD Anderson Cancer Center, 2020 - 2021

Co-Chair, TMC3 Response Task Force, The University of Texas MD Anderson Cancer Center, 2018

Member, President's Advisory Committee, The University of Texas MD Anderson Cancer Center, 2018 - Present

Co-sponsor, Operational Plan Task Force 3 (Education), The University of Texas MD Anderson Cancer Center, 2018 - 2020

Mentee, Mentoring Up Program, The University of Texas MD Anderson Cancer Center, 2017 - 2018

Member, Shared Governance Planning Committee, The University of Texas MD Anderson Cancer Center, 2017 - 2018

Faculty Coordinator, Incident Command System, The University of Texas MD Anderson Cancer Center, 2017 - Present

Director, MD Anderson Physicians Network (MDAPN), The University of Texas MD Anderson Cancer Center, 2016 - Present

Member, Communications, Culture, and Governance Shared Governance Subcommittee (CCGSG), The University of Texas MD Anderson Cancer Center, 2016 - 2017

Member, Shared Governance Committee, The University of Texas MD Anderson Cancer Center, 2016 - Present

Co-Chair, Strategic Hiring Committee, The University of Texas MD Anderson Cancer Center, 2016 - 2017

Chair, Executive Clinical Operations Team (ECOT- Finance), The University of Texas MD Anderson Cancer Center, 2016 - 2017

Member, PRS Executive Council, The University of Texas MD Anderson Cancer Center, 2015 - Present

Co-Chair, Executive Clinical Operations Team (ECOT- Finance), The University of Texas MD Anderson Cancer Center, 2015 - 2016

Member, MD Anderson Physicians Network (MDAPN), The University of Texas MD Anderson Cancer Center, 2015 - 2016

Member, Executive Committee of the Medical Staff (ECMS), The University of Texas MD Anderson Cancer Center, 2015 - Present

Chair, Division of Internal Medicine Executive Council, The University of Texas MD Anderson Cancer Center, 2014 - Present

Member, Leukemia and Blood Cell Development Scientific Advisory Committee, American Cancer Society, 1997 - 1999

Editorial Activities

Member of Editorial Review Board, JAK/STAT, 2011 - Present

Member of Editorial Review Board, Clinical and Translational Science, 2007 - Present

Member of Editorial Review Board, International Journal of Clinical and Experimental Medicine, 2007 - Present

Honors & Awards

2016 - 2024	Fellow, American Association for the Advancement of Science
2008 - 2024	Fellow, American College of Physicians
2007 - 2024	Marquis Who’s Who in America
2006 - 2024	Marquis Who's Who in Science and Engineering
2006 - 2024	Marquis Who's Who in Medicine and Healthcare
2005	Member, American Clinical and Climatological Association, American Clinical and Climatological Association
2005 - 2012	Best Doctors in America
2005	Member, American Association of Physicians, American Association of Physicians
1999 - 2003	Member, Hematology-2 Study Section, National Institutes of Health
1997 - 1999	Member, Leukemia and Blood Cell Development Scientific Advisory Committee, American Cancer Society
1997 - 2024	Fellow, Infectious Diseases Society of America
1995	A. L. Bortree lecturer, Pennsylvania State University
1986	Physician Scientist Award, National Heart, Lung, and Blood Institute
1986	Leukemia Society Special Fellowship
1978	Aesculapian Club, Harvard Medical School
1974	Sigma Xi, Princeton Chapter
1973	National Science Foundation Research Apprenticeship Award

Professional Memberships

American College of Physicians

2008 - Present

Association of American Physicians

2005 - Present

American Clinical and Climatological Association

2005 - Present

Texas Infectious Diseases Society

1999 - Present

Houston Infectious Diseases Society

1999 - Present

Harris County Medical Society

1999 - Present

Texas Medical Association

1999 - Present

Infectious Diseases Society of America

1989 - Present

American Society of Hematology

1989 - 2005

Society for Leukocyte Biology

1988 - 1999

American Association for Cancer Research

1987 - Present

American Association for the Advancement of Science

1985 - Present

American Federation for Clinical Research

1981 - 1999

Selected Presentations & Talks

National Presentations

2021. Five Shots at HCC with an Oral Small-Molecule STAT3 Inhibitor. Invited. Five Shots at HCC with an Oral Small-Molecule STAT3 Inhibitor. Houston, TX, US.
2021. Five Shots at HCC with an Oral Small-Molecule STAT3 Inhibitor. Invited. Five Shots at HCC with an Oral Small-Molecule STAT3 Inhibitor. Houston, TX, US.
2019. North American Immuno-Hematology Clinical Education and Research Immuno-Hematology Symposium. Invited. North American Immuno-Hematology Clinical Education and Research Immuno-Hematology Symposium. Columbus, OH, US.
2016. Contribution of TRiC/CCT to Oncoprotein Folding and Function. Invited. Contribution of TRiC/CCT to Oncoprotein Folding and Function. Houston, TX, US.

International Presentations

2019. Direct Targeting of STAT3 Alone and in Combination with Immune Checkpoint Inhibitors to Treat Solid Tumors. Conference. Direct Targeting of STAT3 Alone and in Combination with Immune Checkpoint Inhibitors to Treat Solid Tumors. Paris, FR.

Formal Peers

2017. Targeting STAT3 to Reverse Chronic Fibrosis and Vascular Leakage. Invited, TX, US.
2015. Regulation of Oncoprotein Folding and Function by TRiC/CCT, the Major Eukaryotic Chaperonin. Invited, TX, US.
2014. Targeting STAT3 in Inflammatory Bowel Diseases. Invited, TX, US.
2012. Drugging STAT proteins to treat cancer and inflammatory disorders. Invited, TX, US.
2012. Chemical Biology to Interrogate the Contribution of STAT Proteins to Cancer and Inflammatory Disorders. Invited, TX, US.
2011. Contributions of Abnormal Proteostasis to Cellular Dysfunction. Invited, VA, US.
2009. Chemical probes that target cancer stem cells. Invited, TX, US.
2009. Chemical probes that competitively and selectively inhibit Stat3 activation. Invited, MA, US.
2009. Controlling Inflammation and Apoptosis to Reduce Susceptibility to Acute Bacterial Infections. Invited, MA, US.
2008. Signal transducer and activator of transcription (STAT) 3 in apoptosis control. Invited, TX, US.
2008. Stat3 and TRiC interactions in apoptosis control. Invited, CA, US.
2008. Harnessing the protein-folding machinery to modulate programmed cell death (apoptosis) and treat disease. Invited, TX, US.
2008. Update on West Nile Virus. Invited, TX, US.
2008. Translating Science into Personalized Health Care: the View from Baylor College of Medicine. Invited, OH, US.
2006. Structure-Assisted Targeting of Signal Transducer and Activator of Transcription (STAT) 3 for Cancer Treatment and Chemical Genetics. Invited, TX, US.
2005. Enhancing or eliminating signals for cell survival to treat disease. Invited, CA, US.
2005. Enhancing or eliminating signals for cell survival to treat disease. Invited, TX, US.
2003. Targeting Stat3 interactions for cancer therapy. Invited, TX, US.
2001. Stat3 in Cell Growth and Differentiation. Invited, TX, US.
2000. Local and systemic G-CSF and IL-6 in hemorrhagic shock. Invited, TX, US.
2000. Stat3 SH2-receptor phosphotyrosine interactions in cell growth and interactions. Invited, TX, US.
1999. G-CSF in inflammation and infection. Invited, PA, US.
1999. STAT3 in Cell Growth, Differentiation and Inflammation. Invited, PA, US.
1999. Local G-CSF and IL-6 in hemorrhagic shock. Invited, TX, US.
1999. Systemic G-CSF and IL-6 in hemorrhagic shock. Invited, TX, US.
1999. Toward reducing nosocomial pneumonia in shock/trauma patients. Invited, TX, US.
1999. Stat3 in Cell Growth and Differentiation. Invited, TX, US.
1999. G-CSF and IL-6 in hemorrhagic shock. Invited, TX, US.
1998. Stat3: a second messenger with much to say. Invited, PA, US.
1998. Stat3 in cell growth, differentiation, inflammation and infection. Invited, TX, US.
1998. G-CSF and IL-6 in inflammation and infection. Invited, IL, US.
1998. Stat3 in cell proliferation, differentiation and systemic infection. Invited, NY, US.
1997. STAT proteins in normal and neoplastic cell growth and differentiation. Invited, PA, US.
1997. Neutrophils and G-CSF in Rheumatoid Arthritis. Invited, PA, US.
1997. Repertoire and mapping of STAT proteins activated by the G-CSFR in normal and neoplastic myeloid cells. Invited, AT.
1996. G-CSF, STAT proteins, and Myeloid Differentiation. Invited, PA, US.
1996. Role of G-CSF in Lung Damage in Hemorrhagic Shock. Invited, PA, US.
1996. G-CSF: The Good, the Bad, and the Ugly. Invited, PA, US.
1996. G-CSF Signaling in Normal and Leukemic Myeloid Cells. Invited, MO, US.
1995. G-CSF Receptor Structure and Signaling in Normal and Leukemic Myeloid Cells: Trouble Lurking Just Beneath the Surface. Invited, MD, US.
1995. G-CSF: The Dark Side. Invited, PA, US.
1995. Staphylococcus Aureus Endocarditis. Invited, PA, US.
1995. G-CSF Signaling: The Cytokine Receptor Paradigm with a Twist. Invited, PA, US.
1994. Early Events in G-CSF Receptor Signaling: Crossing Paradigms. Invited, PA, US.
1994. Early Events in G-CSF Receptor Signaling: Crossing Paradigms. Invited, PA, US.
1994. G-CSF: From the Bench to the Bedside. Invited, PA, US.
1994. Human G-CSF Receptor Structure, Expression, and Signaling in Normal and Leukemic Myeloid Cells. Invited, PA, US.
1992. Human G-CSF and its Receptor in Normal and Leukemic Myeloid Cells. Invited, PA, US.
1991. The G-CSF Receptor in Normal and Leukemic Myeloid Cells. Invited, TN, US.
1989. Control of Myeloid Growth and Differentiation. Invited, PA, US.
1989. Identification of Candidate Genes Induced by Granulocyte Colony-Stimulating Factor. Invited, PA, US.
1988. Control of Colony-Stimulating Factor Production. Invited, PA, US.
1988. Colony-Stimulating Factors and Neutrophil Differentiation and Activation. Invited, PA, US.
1988. Colony-Stimulating Factors and a Model of Myeloid Growth and Differentiation. Invited, OH, US.
1987. Characterization and Cloning of Granulocyte Colony-Stimulating Factor (G-CSF). Invited, PA, US.
1987. Role of Granulocyte Colony-Stimulating Factor (G-CSF) in Hemopoiesis. Invited, PA, US.
1987. Control of Granulocyte Production and Function by Colony-Stimulating Factors. Invited, PA, US.
1986. T-Leukemia Derived Suppressor Lymphokine (TLSL): Biology and Biochemistry. Invited, CO, US.
1986. T-Leukemia Derived Suppressor Lymphokine (TLSL): Biology and Biochemistry. Invited, PA, US.
1986. Cytokine Regulation of Normal Hemopoietic Cell and Leukemic Cell Growth and Differentiation. Invited, PA, US.
1986. University of Pittsburgh School of Medicine. Invited, PA, US.

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Grant & Contract Support

Date:	2025 - 2027
Title:	TTI-101: Candidate Therapeutic for Chemotherapy-Induced Cognitive Impairment
Funding Source:	Institution
Role:	PI
ID:	Cancer Neuroscience Program (CNP)

Date:	2025 - 2027
Title:	Drug targeting of RASH3D19 in KRAS mutant cancers
Funding Source:	Institution
Role:	Co-PI
ID:	Initiative for Generating Novel Ideas towards Translational Enterprises (IGNITE) Program

Date:	2023 - 2028
Title:	Targeting non-small cell lung cancer cells and the adverse tumor microenvironment with a small-molecule STAT3 inhibitor
Funding Source:	NIH/NCI
Role:	PI
ID:	1R01CA279452-01A1

Date:	2023 - 2026
Title:	PREVENT CRC2 - Further Development of iPSC-based vaccine for colon cancer prevention
Funding Source:	NIH/NCI
Role:	CO-I
ID:	75N91019D00021

Date:	2023 - 2028
Title:	Dissecting and targeting tumor-TME crosstalk to forestall acquired KRASG12C inhibitor resistance in NSCLC
Funding Source:	NIH/NCI
Role:	CO-I
ID:	1R01CA279194-01

Date:	2022 - 2025
Title:	PREVENT- Targeting STAT3 to Prevent Non-Small Cell Lung Cancer (NSCLC) in Patients with Chronic Obstructive Pulmonary Disease (COPD)
Funding Source:	NIH/NCI
Role:	PI
ID:	75N91019D00021

Date:	2022 - 2025
Title:	CP210016 Targeting STAT3 Signaling to Promote Recovery from Neuropathic Pain
Funding Source:	DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP)
Role:	PI
ID:	W81XWH2210681/W81XWH2210685

Date:	2022 - 2027
Title:	Targeting head and neck cancer cells and the adverse tumor microenvironment with a novel small-molecule STAT3 inhibitor
Funding Source:	NIH/NCI
Role:	PI
ID:	1 R01 CA269516-01

Date:	2022 - 2024
Title:	Structural analysis of TTI-101 complexed to STAT3 by X-ray crystallography and the genetic validation of its mechanism of action in breast cancer cell lines
Funding Source:	Tvardi Therapeutics, Inc
Role:	PI

Date:	2022 - 2027
Title:	Mechanisms of myocarditis and progressive cardiac fibrosis in chronic Trypanosoma cruzi infection
Funding Source:	NIH/NCI
Role:	CO-I
ID:	R01 Chagas Subaward

Date:	2021 - 2023
Title:	PREVENT- Targeting STAT3 to prevent colorectal cancer secondary to inflammatory bowel disease
Funding Source:	NIH/NCI
Role:	PI
ID:	75N91019D00021

Date:	2020 - 2025
Title:	Targeting STAT3 for the treatment of CDK4/6 inhibitor resistant advanced estrogen receptor positive breast cancer patients
Funding Source:	NIH/NCI
Role:	CO-I
ID:	R01CA255960

Date:	2020 - 2023
Title:	PREVENT- Targeting STAT3 to prevent hepatocellular carcinoma (HCC) associated with non-alcoholic steatohepatitis (NASH)
Funding Source:	NIH/NCI
Role:	PI
ID:	75N91019D00021

Date:	2019 - 2024
Title:	MD Anderson Cancer Center SPORE in Hepatocellular Carcinoma: Project 2: Targeting STAT3 with an oral small molecule to treat hepatocellular carcinoma (HCC)
Funding Source:	NIH/NCI
Role:	Project Leader
ID:	1P50CA217674-01A1

Date:	2019 - 2024
Title:	MD Anderson Cancer Center SPORE in Gastrointestinal Cancer: Project 2: Targeting STAT3 to prevent colorectal cancer (CRC) in hereditary syndromes and inflammatory bowel disease
Funding Source:	NIH/NCI
Role:	Project Leader
ID:	1P50CA221707-01A1

Date:	2018 - 2024
Title:	Clinical trials of C188-9, an oral inhibitor of signal transducer and activator of transcription (STAT) 3, in patients with hepatocellular carcinoma (HCC)
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	Principal Investigator-MDACC
ID:	RP180473

Date:	2016 - 2018
Title:	Targeting STAT3 in systemic sclerosis and dermal fibrosis
Funding Source:	Scleroderma Foundation
Role:	CO-I
ID:	Scleroderma Foundation

Date:	2016 - 2021
Title:	Oral small molecule STAT3 inhibitor to treat cachexia in chronic kidney disease
Funding Source:	NIH/NCI
Role:	PI
ID:	R42 DK 104494

Date:	2014 - 2017
Title:	Oral STAT3 inhibitor as targeted treatment for triple-negative breast cancer
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	PI
ID:	DP150069

Date:	2014 - 2018
Title:	Oral small molecule STAT3 inhibitor to treat breast cancer
Funding Source:	V Foundation
Role:	PI
ID:	V Foundation for Cancer Translational Research Award

Date:	2014 - 2017
Title:	Targeting STAT1 and STAT3 to reverse radio-resistance in head and neck cancer
Funding Source:	NIH/NCI
Role:	PI
ID:	R21 CA191556

Date:	2014 - 2015
Title:	Oral STAT3 inhibitor to treat and prevent lung cancer
Funding Source:	Dan L. Duncan Cancer Center
Role:	PI
ID:	Dan L. Duncan Cancer Center

Date:	2014 - 2019
Title:	Research training in infections and immunity
Funding Source:	NIH/NIAID
Role:	PI
ID:	T32 AI55413

Date:	2013 - 2014
Title:	Targeting STAT3 in asthma
Funding Source:	Papadopoulos Foundation
Role:	PI
ID:	Papadopoulos Allergic Disease Pilot Award

Date:	2013 - 2015
Title:	Role of STAT3 in the pathogenesis of inflammatory bowel disease
Funding Source:	NIH/NIAID
Role:	CO-I
ID:	R03 AI099405

Date:	2013 - 2016
Title:	JAK2-STAT5 pathway blockade to prevent breast cancer
Funding Source:	Susan G. Komen Breast Cancer Foundation
Role:	Co-PI
ID:	Susan G. Komen for the Cure Investigator Initiated Research Grant 223625

Date:	2012 - 2014
Title:	Potent organometallic inhibitors of signal transducer and activator of transcription 3 (STAT3)
Funding Source:	NIH/NCI
Role:	Co-PI
ID:	R21 CA170625-01

Date:	2012 - 2014
Title:	Chemical probes that target STAT3 to treat cancer
Funding Source:	NIH/NCI
Role:	PI
ID:	R41CA153658

Date:	2012 - 2014
Title:	STAT5 as a molecular target in breast cancer prevention
Funding Source:	Baylor College of Medicine
Role:	CO-I
ID:	CDMRP BC112704

Date:	2012 - 2013
Title:	Potent organometallic inhibitors of signal transducer and activator of transcription 3 (STAT3)
Funding Source:	Simmons Family Foundation
Role:	Co-PI
ID:	Simmons Family Foundation Collaborative Research Award

Date:	2011 - 2012
Title:	Combining STAT3 inhibition and T-cell immunotherapy as a novel treatment for glioblastoma multiforme
Funding Source:	Alkek Pilot Project in Experimental Therapeutics Award
Role:	PI
ID:	Alkek Pilot Project in Experimental Therapeutics Award

Date:	2010 - 2014
Title:	Prevention of trauma/hemorrhagic shock-induced mortality, apoptosis, inflammation and mitochondrial dysfunction using IL-6 as a resuscitation adjuvant
Funding Source:	DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP)
Role:	PI
ID:	W81XWH-11-2-018

Date:	2010 - 2012
Title:	Targeting oncoprotein folding intermediates to treat cancer
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	PI
ID:	RP110291

Date:	2010 - 2010
Title:	Prevention of acute lung injury by IL-6 activated STAT3
Funding Source:	NIH/NHLBI
Role:	Sponsor
ID:	K08 HL091119-01A2

Date:	2010 - 2011
Title:	Targeting HNSCC tumor-initiating cells through STAT3
Funding Source:	NIH/NCI
Role:	PI
ID:	P50 CA097007

Date:	2010 - 2012
Title:	STAT3 probes that target breast cancer stem cells
Funding Source:	NIH/NCI
Role:	PI
ID:	R21 CA149783

Date:	2010 - 2012
Title:	Improving STAT3 folding and function to reverse Job’s Syndrome immunodeficiency and reduce staphylococcal skin infections
Funding Source:	Pediatric Infectious Diseases Society
Role:	Sponsor
ID:	Pediatric Infectious Diseases Society (PIDS) Fellowship Award

Date:	2010 - 2013
Title:	Chemical probes for STAT3 that selectively target leukemia initiating cells
Funding Source:	Cancer Prevention & Research Institute of Texas (CPRIT)
Role:	PI
ID:	RP100421

Date:	2009 - 2010
Title:	First and second-generation STAT3 chemical probes to treat oral cavity cancer
Funding Source:	NIH/NCI
Role:	Project Leader
ID:	P50 CA097007

Date:	2009 - 2011
Title:	Chemical probes selective for STAT3α activation
Funding Source:	John S. Dunn Gulf Coast Consortium
Role:	Project Leader
ID:	John S. Dunn Gulf Coast Consortium for Chemical Genomics Discovery Project Grant

Date:	2009 - 2009
Title:	Second generation chemical probes that competitively and selectively inhibit two steps in STAT3 activation
Funding Source:	Dan L. Duncan
Role:	Project Leader
ID:	Dan L. Duncan Cancer Center Pilot Project

Date:	2008 - 2013
Title:	Research training in infections and immunity
Funding Source:	NIH/NCI
Role:	PI
ID:	T32 AI55413

Date:	2008 - 2013
Title:	STAT3 isoforms in maturation and survival of normal and malignant myeloid cells
Funding Source:	NIH/NCI
Role:	Sponsor
ID:	K08 HL085018-01A2

Date:	2007 - 2009
Title:	Chemical probes selective for STAT3α inhibition
Funding Source:	John S. Dunn Gulf Coast Consortium
Role:	Project Leader
ID:	John S. Dunn Gulf Coast Consortium for Chemical Genomics Discovery Project Grant

Date:	2007 - 2009
Title:	IL-6-activated STAT3 prevention of hemorrhagic shock-induced apoptosis
Funding Source:	American Lung Association
Role:	Sponsor
ID:	American Lung Association

Date:	2007 - 2008
Title:	Selective small-molecule-targeting of signal transducer and activator of transcription (STAT) 3 at two steps in its activation to treat high-risk breast cancer
Funding Source:	NIH/NCI
Role:	Project Leader
ID:	P50 CA058183

Date:	2007 - 2010
Title:	Clinical Translational Research Career Development Award in Pediatric Cancer
Funding Source:	Larry and Helen Hoag Foundation
Role:	Sponsor
ID:	Larry and Helen Hoag Foundation

Date:	2005 - 2010
Title:	Novel inhibitor of STAT3 for prostate cancer therapy
Funding Source:	NIH/NCI
Role:	CO-I
ID:	R01 CA104035

Date:	2005 - 2009
Title:	TNF alpha signaling in hemorrhagic shock
Funding Source:	NIH/NCI
Role:	CO-I
ID:	R01 HL73017

Date:	2004 - 2014
Title:	Center for protein folding machinery, NIH Roadmap Initiative in Nanomedicine. Project Title: STAT3 and TRiC interactions in apoptosis control
Funding Source:	NIH/NEI
Role:	Program Leader
ID:	PN1EY016525

Date:	2004 - 2009
Title:	Reversal of hypovolemic circulatory collapse by IL-6
Funding Source:	NIH/NCI
Role:	PI
ID:	R01 HL76169

Date:	2003 - 2008
Title:	Research training in infections and immunity
Funding Source:	NIH/NCI
Role:	PI
ID:	T32 AI55413

Date:	2003 - 2006
Title:	Targeting STAT3 using oligonucleotides in metastatic prostate cancer
Funding Source:	DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP)
Role:	CO-I
ID:	PC020407

Date:	2003 - 2013
Title:	Immunology physician scientist training grant
Funding Source:	NIH/NCI
Role:	Mentoring Faculty
ID:	T32 AI53831

Date:	2002 - 2003
Title:	Effect of APL fusion proteins on nuclear localization and mobility of RAR and RXR
Funding Source:	Baylor College of Medicine
Role:	PI
ID:	Basic/Clinical Collaborative Research Program

Date:	2002 - 2013
Title:	Hematology training grant
Funding Source:	NIH/NCI
Role:	Mentoring Faculty
ID:	T32DK60445

Date:	2002 - 2007
Title:	Critically ill developing host from pathogenesis to outcome
Funding Source:	NIH/NCI
Role:	Mentoring Faculty
ID:	T32 HL07939

Date:	2002 - 2008
Title:	Mechanisms of G-CSF receptor mediated differentiation
Funding Source:	NIH/NCI
Role:	PI
ID:	R01 CA72261

Date:	1999 - 2005
Title:	STAT3 interactions in cell growth and differentiation
Funding Source:	NIH/NCI
Role:	PI
ID:	R01 CA86430

Date:	1999
Title:	Training in trauma and sepsis research
Funding Source:	NIH/NCI
Role:	Faculty
ID:	T32 GM08516

Date:	1998 - 2000
Title:	National Research Service Award Role of STAT3 in G-CSF-mediated myeloid differentiation
Funding Source:	NIH/NCI
Role:	Sponsor
ID:	F32CA77928

Date:	1998 - 1998
Title:	STAT-mediated TGF-α/EGFR signaling in squamous cell carcinoma of the head and neck
Funding Source:	NIH/NCI
Role:	CO-I
ID:	R01 CA77308

Date:	1998 - 1998
Title:	Role of STAT3 in G-CSF-mediated myeloid differentiation
Funding Source:	Lauri-Strauss Leukemia Foundation
Role:	Sponsor
ID:	Lauri-Strauss Leukemia Foundation Postdoctoral Award

Date:	1998 - 1999
Title:	Multipurpose arthritis and musculo-skeletal diseases center grant Project 5: Neutrophils and G-CSF in rheumatoid arthritis
Funding Source:	NIH/NCI
Role:	PI
ID:	P60 AR44611

Date:	1997 - 1999
Title:	Research training in AIDS, STDs, and intracellular pathogens
Funding Source:	NIH/NCI
Role:	PI
ID:	T32 AI07333

Date:	1997 - 1999
Title:	Molecular biology of hemorrhagic shock Project 3: Neutrophils and G-CSF in hemorrhagic shock
Funding Source:	NIH/NCI
Role:	PI
ID:	P50 GM53789

Date:	1996 - 2001
Title:	Mechanisms of G-CSF receptor mediated differentiation
Funding Source:	NIH/NCI
Role:	PI
ID:	R01 CA72261

Date:	1995 - 1999
Title:	G-CSF receptor isoforms and myeloid leukemogenesis
Funding Source:	NIH/NCI
Role:	Sponsor
ID:	K11 CA68479

Date:	1994 - 1999
Title:	Postdoctoral research training in head and neck cancer
Funding Source:	NIH/NCI
Role:	Faculty
ID:	T32 CA60397

Date:	1994 - 1996
Title:	G-CSF signaling in myeloid leukemia
Funding Source:	American Cancer Society (ACS)
Role:	PI
ID:	DHP-111

Date:	1994 - 1997
Title:	Posttraumatic sepsis--regulation of LPS-binding protein
Funding Source:	NIH/NCI
Role:	Collaborator
ID:	R01 GM50441

Date:	1993 - 1998
Title:	Autocrine growth in head and neck cancer
Funding Source:	NIH/NCI
Role:	Sponsor
ID:	K11 CA01760

Date:	1991 - 1995
Title:	Hepatocyte: Kupffer cell interactions in surgical sepsis
Funding Source:	NIH/NCI
Role:	CO-I
ID:	R01GM37753

Date:	1991 - 1994
Title:	Genetics of human T-cell response to cytomegalovirus
Funding Source:	NIH/NCI
Role:	CO-I
ID:	R01AI29027

Date:	1991 - 1994
Title:	Mathematical modeling of immunological reactions
Funding Source:	NIH/NCI
Role:	CO-I
ID:	R01 AI31427

Date:	1991 - 1994
Title:	Host defense mechanisms in listeria infection
Funding Source:	NIH/NCI
Role:	CO-I
ID:	R01 AI24141

Date:	1991 - 1993
Title:	Molecular control of myeloid growth and differentiation
Funding Source:	American Cancer Society (ACS)
Role:	PI
ID:	CH 503

Date:	1990 - 1995
Title:	Effectors in the allograft response
Funding Source:	NIH/NCI
Role:	CO-I
ID:	R01 AI16869

Date:	1988 - 1989
Title:	Engineering of hemopoietic cells
Funding Source:	National Science Foundation (NSF)
Role:	Co-PI
ID:	EET 8825634

Date:	1987 - 1989
Title:	Inhibition of normal hemopoiesis in leukemia by a novel lymphokine
Funding Source:	American Cancer Society (ACS)
Role:	PI
ID:	CH384

Date:	1986 - 1991
Title:	Suppression of hemopoiesis by a novel lymphokine
Funding Source:	NIH/NCI
Role:	PI
ID:	K11 HL-07763

Selected Publications

Peer-Reviewed Articles

Robinson, P, Italia, Z, Italia, Z, Hoang, T, Rodriguez, E, Eckols, TK, Kasembeli, MM, Zorrilla, LH, Solis Soto, LM, Mahalingam, R, Tweardy, D. STAT3 Inhibition to Treat Ulcerative Colitis-Associated Colorectal Cancer. International journal of molecular sciences 26(21), 2025. e-Pub 2025. PMID: 41226842.
Kettner NM, Bui TN, Navarro-Yepes J, Ghotbaldini S, Quintela B, Luo CK, Lam N, Rao X, Raghavendra AS, Wang Y, Azizian N, Kris Eckols T, Kasembeli MM, Evans K, Yi M, Wingate H, Wang J, Sahin AA, Meric-Bernstam F, Hunt KK, Damodaran S, Tweardy DJ, Tripathy D, Keyomarsi K. IL-6 predicts CDK4/6 inhibitor resistance, identifying STAT3 as a target in HR + /HER2-negative metastatic breast cancer. NPJ Precis Oncol 9(1):260, 2025. e-Pub 2025. PMID: 40715551.
Tsimberidou, AM, Vining, D, Arora, SP, De Achaval, S, Larson, J, Kauh, J, Cartwright, CA, Avritscher, R, Alibhai, I, Tweardy, D, Kaseb, A. Phase I Trial of TTI-101, a First-in-Class Oral Inhibitor of STAT3, in Patients with Advanced Solid Tumors. Clinical Cancer Research 31(6):965-974, 2025. e-Pub 2025. PMID: 39792482.
Clowers, MJ, Rahal, Z, Cho, SN, Krishna, A, Yuan, B, Hamana Zorrilla, L, Eckols, TK, Kasembeli, MM, Liu, S, Peng, SA, Ramos-Castañeda, M, Thompson, AL, Rodriguez Reyna, CI, Larsen, KE, Grimaldo, MT, Deng, S, Karimi, N, Chou, C, Velasco, WV, Zarghooni, M, Alekseev, S, Solis Soto, LM, Ostrin, EJ, Kadara, HN, Ekmekcioglu, S, Tweardy, D, Moghaddam, SM. Selective inhibition of canonical STAT3 signaling suppresses K-ras mutant lung tumorigenesis and reinvigorates anti-tumor immunity. Frontiers in immunology 16, 2025. e-Pub 2025. PMID: 40356899.
Robinson P, Montoya K, Magness E, Rodriguez E, Villalobos V, Engineer N, Yang P, Bharadwaj U, Eckols TK, Tweardy DJ. Therapeutic Potential of a Small-Molecule STAT3 Inhibitor in a Mouse Model of Colitis. Cancers (Basel) 15(11), 2023. e-Pub 2023. PMID: 37296943.
Kasembeli MM, Kaparos E, Bharadwaj U, Allaw A, Khouri A, Acot B, Tweardy DJ. Aberrant function of pathogenic STAT3 mutant proteins is linked to altered stability of monomers and homodimers. Blood 141(12):1411-1424, 2023. e-Pub 2023. PMID: 36240433.
Jiao J, Sanchez JI, Saldarriaga OA, Solis LM, Tweardy DJ, Maru DM, Stevenson HL, Beretta L. Spatial molecular and cellular determinants of STAT3 activation in liver fibrosis progression in non-alcoholic fatty liver disease. JHEP Rep 5(2):100628, 2023. e-Pub 2023. PMID: 36687470.
Robinson P, Magness E, Montoya K, Engineer N, Eckols TK, Rodriguez E, Tweardy DJ. Genetic and Small-Molecule Modulation of STAT3 in a Mouse Model of Crohn's Disease. J Clin Med 11(23), 2022. e-Pub 2022. PMID: 36498596.
Tweardy DJ. Drugging "undruggable" disease-causing proteins: focus on signal transducer and activator of transcription (STAT) 3. Trans Am Clin Climatol Assoc 132:61-76, 2022. e-Pub 2022. PMID: 36196170.
Kasembeli MM, Singhmar P, Ma J, Edralin J, Tang Y, Adams C, Heijnen CJ, Kavelaars A, Tweardy DJ. TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain. Biochem Pharmacol 192:114688, 2021. e-Pub 2021. PMID: 34274354.
Kong R, Bharadwaj U, Eckols TK, Kolosov M, Wu H, Cruz-Pavlovich FJS, Shaw A, Ifelayo OI, Zhao H, Kasembeli MM, Wong STC, Tweardy DJ. Novel STAT3 small-molecule inhibitors identified by structure-based virtual ligand screening incorporating SH2 domain flexibility. Pharmacol Res 169:105637, 2021. e-Pub 2021. PMID: 33932608.
Hoffman KA, Villar MJ, Poveda C, Bottazzi ME, Hotez PJ, Tweardy DJ, Jones KM. Signal Transducer and Activator of Transcription-3 Modulation of Cardiac Pathology in Chronic Chagasic Cardiomyopathy. Front Cell Infect Microbiol 11:708325, 2021. e-Pub 2021. PMID: 34504808.
Zhang L, Wang Y, Dong Y, Chen Z, Eckols TK, Kasembeli MM, Tweardy DJ, Mitch WE. Pharmacokinetics and pharmacodynamics of TTI-101, a STAT3 inhibitor that blocks muscle proteolysis in rats with chronic kidney disease. Am J Physiol Renal Physiol 319(1):F84-F92, 2020. e-Pub 2020. PMID: 32475130.
Minus MB, Wang H, Munoz JO, Stevens AM, Mangubat-Medina AE, Krueger MJ, Liu W, Kasembeli MM, Cooper JC, Kolosov MI, Tweardy DJ, Redell MS, Ball ZT. Targeting STAT3 anti-apoptosis pathways with organic and hybrid organic-inorganic inhibitors. Org Biomol Chem 18(17):3288-3296, 2020. e-Pub 2020. PMID: 32286579.
Zhang L, Chen Z, Wang Y, Tweardy DJ, Mitch WE. Stat3 activation induces insulin resistance via a muscle-specific E3 ubiquitin ligase Fbxo40. Am J Physiol Endocrinol Metab 318(5):E625-E635, 2020. e-Pub 2020. PMID: 32101031.
Sharma M, Khong H, Fa'ak F, Bentebibel SE, Janssen LME, Chesson BC, Creasy CA, Forget MA, Kahn LMS, Pazdrak B, Karki B, Hailemichael Y, Singh M, Vianden C, Vennam S, Bharadwaj U, Tweardy DJ, Haymaker C, Bernatchez C, Huang S, Rajapakshe K, Coarfa C, Hurwitz ME, Sznol M, Hwu P, Hoch U, Addepalli M, Charych DH, Zalevsky J, Diab A, Overwijk WW. Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy. Nat Commun 11(1):661, 2020. e-Pub 2020. PMID: 32005826.
Kettner NM, Vijayaraghavan S, Durak MG, Bui T, Kohansal M, Ha MJ, Liu B, Rao X, Wang J, Yi M, Carey JPW, Chen X, Eckols TK, Raghavendra AS, Ibrahim NK, Karuturi MS, Watowich SS, Sahin A, Tweardy DJ, Hunt KK, Tripathy D, Keyomarsi K. Combined Inhibition of STAT3 and DNA Repair in Palbociclib-Resistant ER-Positive Breast Cancer. Clin Cancer Res 25(13):3996-4013, 2019. e-Pub 2019. PMID: 30867218.
Vicente D, Patino M, Marcus R, Lillmoe H, Limani P, Newhook T, Lee A, Tzeng CW, Segraves-Chun Y, Tweardy DJ, Gottumukkala V, Vauthey JN, Aloia T, Cata JP. Impact of epidural analgesia on the systemic biomarker response after hepatic resection. Oncotarget 10(5):584-594, 2019. e-Pub 2019. PMID: 30728909.
Hassan MM, Botrus G, Abdel-Wahab R, Wolff RA, Li D, Tweardy DJ, Phan AT, Hawk E, Javle M, Lee JS, Torres HA, Rashid A, Lenzi R, Hassabo HM, Abaza Y, Shalaby AS, Lacin S, Morris J, Patt YZ, Amos CI, Khaderi SA, Goss JA, Jalal PK, Kaseb AO. Estrogen Replacement Reduces Risk and Increases Survival Times of Women With Hepatocellular Carcinoma. Clin Gastroenterol Hepatol 15(11):1791-1799, 2017. e-Pub 2017. PMID: 28579181.
Singh M, Vianden C, Cantwell MJ, Dai Z, Xiao Z, Sharma M, Khong H, Jaiswal AR, Faak F, Hailemichael Y, Janssen LME, Bharadwaj U, Curran MA, Diab A, Bassett RL, Tweardy DJ, Hwu P, Overwijk WW. Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain. Nat Commun 8(1):1447, 2017. e-Pub 2017. PMID: 29129918.
Jung KH, Yoo W, Stevenson HL, Deshpande D, Shen H, Gagea M, Yoo SY, Wang J, Eckols TK, Bharadwaj U, Tweardy DJ, Beretta L. Multi-functional effects of a small-molecule STAT3 inhibitor on NASH and HCC in mice. Clin Cancer Res 23(18):5537-5546, 2017. e-Pub 2017. PMID: 28533225.
Pedroza M, To S, Assassi S, Wu M, Tweardy DJ, Agarwal SK. Role of STAT3 in skin fibrosis and transforming growth factor beta signalling. Rheumatology (Oxford). e-Pub 2017. PMID: 29029263.
Gavino AC, Nahmod K, Bharadwaj U, Makedonas G, Tweardy DJ. STAT3 inhibition prevents lung inflammation, remodeling, and accumulation of Th2 and Th17 cells in a murine asthma model. Allergy 71(12):1684-1692, 2016. e-Pub 2016. PMID: 27225906.
Bocchini CE, Nahmod K, Katsonis P, Kim S, Kasembeli MM, Freeman A, Lichtarge O, Makedonas G, Tweardy DJ. Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome. Blood 128(26):3061-3072, 2016. e-Pub 2016. PMID: 27799162.
Mahale P, Sturgis EM, Tweardy DJ, Ariza-Heredia EJ, Torres HA. Association Between Hepatitis C Virus and Head and Neck Cancers. J Natl Cancer Inst 108(8), 2016. e-Pub 2016. PMID: 27075854.
Hox V, O'Connell MP, Lyons JJ, Sackstein P, Dimaggio T, Jones N, Nelson C, Boehm M, Holland SM, Freeman AF, Tweardy DJ, Olivera A, Metcalfe DD, Milner JD. Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis. J Allergy Clin Immunol 138(1):187-199, 2016. e-Pub 2016. PMID: 26948077.
Roh SH, Kasembeli MM, Galaz-Montoya JG, Chiu W, Tweardy DJ. Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions. Biophys J 110(11):2377-2385, 2016. e-Pub 2016. PMID: 27276256.
Bharadwaj U, Eckols TK, Xu X, Kasembeli MM, Chen Y, Adachi M, Song Y, Mo Q, Lai SY, Tweardy DJ. Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget 7(18):26307-26330, 2016. e-Pub 2016. PMID: 27027445.
Li N, Feng L, Liu H, Wang J, Kasembeli M, Tran MK, Tweardy DJ, Lin SH, Chen J. PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2. Cell Rep. e-Pub 2016. PMID: 27149849.
Roh SH, Kasembeli M, Galaz-Montoya JG, Trnka M, Lau WC, Burlingame A, Chiu W, Tweardy DJ. Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO. J Biol Chem 291(9):4732-4741, 2016. e-Pub 2016. PMID: 26706127.
Zhang HF, Chen Y, Wu C, Wu ZY, Tweardy DJ, Alshareef A, Liao LD, Xue YJ, Wu JY, Chen B, Xu XE, Gopal K, Gupta N, Li EM, Xu LY, Lai R. The opposing function of STAT3 as an oncoprotein and tumor suppressor is dictated by the expression status of STAT3β in esophageal squamous cell carcinoma. Clin Cancer Res 22(3):691-703, 2016. e-Pub 2016. PMID: 26405196.
Zheng M, Turton KB, Zhu F, Li Y, Grindle KM, Annis DS, Lu L, Drennan AC, Tweardy DJ, Bharadwaj U, Mosher DF, Rui L. A mix of S and delta-S variants of STAT3 enable survival of activated B-cell-like diffuse large B-cell lymphoma cells in culture. Oncogenesis 4:e184, 2016. e-Pub 2016. PMID: 26727576.
Pedroza M, Le TT, Lewis K, Karmouty-Quintana H, To S, George AT, Blackburn MR, Tweardy DJ, Agarwal SK. STAT-3 contributes to pulmonary fibrosis through epithelial injury and fibroblast-myofibroblast differentiation. FASEB J 30(1):129-140, 2016. e-Pub 2016. PMID: 26324850.
Robinson P, Kasembeli M, Bharadwaj U, Engineer N, Eckols KT, Tweardy DJ. Substance P Receptor Signaling Mediates Doxorubicin-Induced Cardiomyocyte Apoptosis and Triple-Negative Breast Cancer Chemoresistance. Biomed Res Int 2016:1959270, 2016. e-Pub 2016. PMID: 26981525.
Lewis KM, Bharadwaj U, Eckols TK, Kolosov M, Kasembeli MM, Fridley C, Siller R, Tweardy DJ. Small-molecule targeting of signal transducer and activator of transcription (STAT) 3 to treat non-small cell lung cancer. Lung Cancer 90(2):182-190, 2015. e-Pub 2015. PMID: 26410177.
Minus MB, Liu W, Vohidov F, Kasembeli MM, Long X, Krueger MJ, Stevens A, Kolosov MI, Tweardy DJ, Sison EA, Redell MS, Ball ZT. Rhodium(II) proximity-labeling identifies a novel target site on STAT3 for inhibitors with potent anti-leukemia activity. Angew Chem Int Ed Engl 54(44):13085-13089, 2015. e-Pub 2015. PMID: 26480340.
Silva KA, Dong J, Dong Y, Dong Y, Schor N, Tweardy DJ, Zhang L, Mitch WE. Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia. J Biol Chem 290(17):11177-11187, 2015. e-Pub 2015. PMID: 25787076.
Bharadwaj U, Eckols TK, Kolosov M, Kasembeli MM, Adam A, Torres D, Zhang X, Dobrolecki LE, Wei W, Lewis MT, Dave B, Chang JC, Landis MD, Creighton CJ, Mancini MA, Tweardy DJ. Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer. Oncogene 0(11):1341-1353, 2015. e-Pub 2015. PMID: 24681959.
Yuan H, Houck KL, Tian Y, Bharadwaj U, Hull K, Zhou Z, Zhou M, Wu X, Tweardy DJ, Romo D, Fu X, Zhang Y, Zhang J, Dong JF. Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species . PLoS One 10(12):e0143964, 2015. e-Pub 2015. PMID: 26645674.
Wei W, Tweardy DJ, Zhang M, Zhang X, Landua J, Petrovic I, Bu W, Roarty K, Hilsenbeck SG, Rosen JM, Lewis MT. STAT3 signaling is activated preferentially in tumor-initiating cells in claudin-low models of human breast cancer. Stem Cells 32(10):2571-2582, 2014. e-Pub 2014. PMID: 24891218.
Bakthavatsalam D, Soung RH, Tweardy DJ, Chiu W, Dixon RA, Woodside DG. Chaperonin-containing TCP-1 complex directly binds to the cytoplasmic domain of the LOX-1 receptor. FEBS Lett 588(13):2133-2140, 2014. e-Pub 2014. PMID: 24846140.
Hillion J, Belton AM, Shah SN, Turkson J, Jing N, Tweardy DJ, di Cello F, Huso DL, Resar LM. Nanoparticle delivery of inhibitory signal transducer and activator of transcription 3 G-quartet oligonucleotides blocks tumor growth in HMGA1 transgenic model of T-cell leukemia. Leuk Lymphoma 55(5):1194-1197, 2014. e-Pub 2014. PMID: 23829279.
Chatzimpaloglou A, Kolosov M, Eckols TK, Tweardy DJ, Sarli V. Synthetic and biological studies of phaeosphaerides. J Org Chem 79(9):4043-4054, 2014. e-Pub 2014. PMID: 24735379.
Kasembeli M, Lau WC, Roh SH, Eckols TK, Frydman J, Chiu W, Tweardy DJ. Modulation of STAT3 folding and function by TRiC/CCT chaperonin. PLoS Biol 12(4):e1001844, 2014. e-Pub 2014. PMID: 24756126.
Thacker S, Moran A, Lionakis M, Mastrangelo MA, Halder T, del Pilar Huby M, Wu Y, Tweardy DJ. Restoration of lung surfactant protein D by IL-6 protects against secondary pneumonia following hemorrhagic shock. J Infect 68(3):231-241, 2014. e-Pub 2014. PMID: 24291043.
Bharadwaj U, Kasembeli MM, Eckols TK, Kolosov M, Lang P, Christensen K, Edwards DP, Tweardy DJ. Monoclonal Antibodies Specific for STAT3β Reveal Its Contribution to Constitutive STAT3 Phosphorylation in Breast Cancer. Cancers (Basel) 6(4):2012-2034, 2014. e-Pub 2014. PMID: 25268166.
Khumbatta M, Firozgary B, Tweardy DJ, Weinstock J, Firozgary G, Bhatena Z, Bulsara T, Siller R, Robinson P. Somatostatin negatively regulates parasite burden and granulomatous responses in cysticercosis. Biomed Res Int 2014:247182, 2014. e-Pub 2014. PMID: 25530957.
Zhang L, Pan J, Dong Y, Tweardy DJ, Dong Y, Garibotto G, Mitch WE. Stat3 activation links a C/EBPδ to myostatin pathway to stimulate loss of muscle mass. Cell Metab 18(3):368-379, 2013. e-Pub 2013. PMID: 24011072.
Elsarraj HS, Hong Y, Valdez K, Carletti M, Salah SM, Raimo M, Taverna D, Prochasson P, Bharadwaj U, Tweardy DJ, Christenson LK, Behbod F. A novel role of microRNA146b in promoting mammary alveolar progenitor cell maintenance. J Cell Sci 126(Pt 11):2446-2458, 2013. e-Pub 2013. PMID: 23572509.
Redell MS, Ruiz MJ, Gerbing RB, Alonzo TA, Lange BJ, Tweardy DJ, Meshinchi S, Group CO. FACS analysis of Stat3/5 signaling reveals sensitivity to G-CSF and IL-6 as a significant prognostic factor in pediatric AML: a Children's Oncology Group report. Blood 121(7):1083-1093, 2013. e-Pub 2013. PMID: 23243289.
Morrison AC, Moran A, Patel S, Vidaurre Mdel P, Carrick MM, Tweardy DJ. Increased apoptosis of peripheral blood neutrophils is associated with reduced incidence of infection in trauma patients with hemorrhagic shock. J Infect 66(1):87-94, 2013. e-Pub 2013. PMID: 23063873.
Haricharan S, Dong J, Hein S, Reddy JP, Du Z, Toneff M, Holloway K, Hilsenbeck SG, Huang S, Atkinson R, Woodward W, Jindal S, Borges VF, Gutierrez C, Zhang H, Schedin PJ, Osborne CK, Tweardy DJ, Li Y. Mechanism and preclinical prevention of increased breast cancer risk caused by pregnancy. Elife 2:e00996, 2013. e-Pub 2013. PMID: 24381245.
Thacker SA, Robinson P, Abel A, Tweardy DJ. Modulation of the unfolded protein response during hepatocyte and cardiomyocyte apoptosis in trauma/hemorrhagic shock. Sci Rep 3:1187, 2013. e-Pub 2013. PMID: 23378918.
Liao KS, Lehman SM, Tweardy DJ, Donlan RM, Trautner BW. Bacteriophages are synergistic with bacterial interference for the prevention of Pseudomonas aeruginosa biofilm formation on urinary catheters. J Appl Microbiol 113(6):1530-1539, 2012. e-Pub 2012. PMID: 22985454.
Trautner BW, Lopez AI, Kumar A, Siddiq DM, Liao KS, Li Y, Tweardy DJ, Cai C. Nanoscale surface modification favors benign biofilm formation and impedes adherence by pathogens. Nanomedicine 8(3):261-270, 2012. e-Pub 2012. PMID: 22197726.
Weatherhead JE, Tweardy DJ. Lethal human neutropenic entercolitis caused by Clostridium chauvoei in the United States: tip of the iceberg?. J Infect 64(2):225-227, 2012. e-Pub 2012. PMID: 21945880.
Robinson P, Garza A, Weinstock J, Serpa JA, Goodman JC, Eckols KT, Firozgary B, Tweardy DJ. Substance P causes seizures in neurocysticercosis. PLoS Pathog 8(2):e1002489, 2012. e-Pub 2012. PMID: 22346746.
Roig IL, Musher DM, Tweardy DJ. Severe pulmonary involvement in a case attributed to domestically acquired Seoul hantavirus in the United States. Clin Infect Dis 54(1):91-94, 2012. e-Pub 2012. PMID: 22042876.
Dave B, Landis MD, Tweardy DJ, Chang JC, Dobrolecki LE, Wu MF, Zhang X, Westbrook TF, Hilsenbeck SG, Liu D, Lewis MT. Selective small molecule Stat3 inhibitor reduces breast cancer tumor-initiating cells and improves recurrence free survival in a human-xenograft model. PLoS One 7(8):e30207, 2012. e-Pub 2012. PMID: 22879872.
Kelly JD, Teeter LD, Graviss EA, Tweardy DJ. Intracranial tuberculomas in adults: a report of twelve consecutive patients in Houston, Texas. Scand J Infect Dis 43(10):785-791, 2011. e-Pub 2011. PMID: 21696248.
Redell MS, Ruiz MJ, Alonzo TA, Gerbing RB, Tweardy DJ. Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood 117(21):5701-5709, 2011. e-Pub 2011. PMID: 21447830.
Moran A, Thacker SA, Arikan AA, Mastrangelo MA, Wu Y, Yu B, Tweardy DJ. IL-6-mediated activation of Stat3α prevents trauma/hemorrhagic shock-induced liver inflammation. PLoS One 6(6):e21449, 2011. e-Pub 2011. PMID: 21738667.
Qiu JJ, Lu X, Zeisig BB, Ma Z, Cai X, Chen S, Gronemeyer H, Tweardy DJ, So CW, Dong S. Leukemic transformation by the APL fusion protein PRKAR1A-RAR{alpha} critically depends on recruitment of RXR{alpha}. Blood 115(3):643-652, 2010. e-Pub 2010. PMID: 19965660.
Garza A, Tweardy DJ, Weinstock J, Viswanathan B, Robinson P. Substance P signaling contributes to granuloma formation in Taenia crassiceps infection, a murine model of cysticercosis. J Biomed Biotechnol 2010:597086, 2010. e-Pub 2010. PMID: 20150970.
Corrales-Medina VF, Serpa J, Rueda AM, Giordano TP, Bozkurt B, Madjid M, Tweardy DJ, Musher DM. Acute bacterial pneumonia is associated with the occurrence of acute coronary syndromes. Medicine (Baltimore) 88(3):154-159, 2009. e-Pub 2009. PMID: 19440118.
Moran A, Tsimelzon AI, Mastrangelo MA, Wu Y, Yu B, Hilsenbeck SG, Poli V, Tweardy DJ. Prevention of trauma/hemorrhagic shock-induced lung apoptosis by IL-6-mediated activation of Stat3. Clin Transl Sci 2(1):41-49, 2009. e-Pub 2009. PMID: 20443866.
Xu X, Kasembeli MM, Jiang X, Tweardy BJ, Tweardy DJ. Chemical probes that competitively and selectively inhibit Stat3 activation. PLoS One 4(3):e4783, 2009. e-Pub 2009. PMID: 19274102.
Robinson P, Garza A, Moore J, Eckols TK, Parti S, Balaji V, Vallejo J, Tweardy DJ. Substance P is required for the pathogenesis of EMCV infection in mice. Int J Clin Exp Med 2(1):76-86, 2009. e-Pub 2009. PMID: 19436834.
Robinson P, Martin P, Garza A, D'Souza M, Mastrangelo MA, Tweardy DJ. Substance P receptor antagonism for treatment of cryptosporidiosis in immunosuppressed mice. J Parasitol 94(5):1150-1154, 2008. e-Pub 2008. PMID: 18576802.
Garza A, Lackner A, Aye P, D'Souza M, Martin P, Borda J, Tweardy DJ, Weinstock J, Griffiths J, Robinson P. Substance P receptor antagonist reverses intestinal pathophysiological alterations occurring in a novel ex-vivo model of Cryptosporidium parvum infection of intestinal tissues derived from SIV-infected macaques. J Med Primatol 37(3):109-115, 2008. e-Pub 2008. PMID: 18547256.
Alten JA, Moran A, Tsimelzon AI, Mastrangelo MA, Hilsenbeck SG, Poli V, Tweardy DJ. Prevention of hypovolemic circulatory collapse by IL-6 activated Stat3. PLoS One 3(2):e1605, 2008. e-Pub 2008. PMID: 18270592.
Moran A, Akcan Arikan A, Mastrangelo MA, Wu Y, Yu B, Poli V, Tweardy DJ. Prevention of trauma and hemorrhagic shock-mediated liver apoptosis by activation of Stat3alpha. Int J Clin Exp Med 1(3):213-247, 2008. e-Pub 2008. PMID: 18997875.
Huang Y, Qiu J, Dong S, Redell MS, Poli V, Mancini MA, Tweardy DJ. Stat3 isoforms, alpha and beta, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3beta mapping to its unique C-terminal end. J Biol Chem 282(48):34958-34967, 2007. e-Pub 2007. PMID: 17855361.
Redell MS, Tsimelzon A, Hilsenbeck SG, Tweardy DJ. Conditional overexpression of Stat3alpha in differentiating myeloid cells results in neutrophil expansion and induces a distinct, antiapoptotic and pro-oncogenic gene expression pattern. J Leukoc Biol 82(4):975-985, 2007. e-Pub 2007. PMID: 17634277.
Hernandez J, Lackner A, Aye P, Mukherjee K, Tweardy DJ, Mastrangelo MA, Weinstock J, Griffiths J, D'Souza M, Dixit S, Robinson P. Substance P is responsible for physiological alterations such as increased chloride ion secretion and glucose malabsorption in cryptosporidiosis. Infect Immun 75(3):1137-1143, 2007. e-Pub 2007. PMID: 17158891.
Shelburne SA, Greenberg SB, Aslam S, Tweardy DJ. Successful ceftriaxone therapy of endocarditis due to penicillin non-susceptible viridans streptococci. J Infect 54(2):e99-e101, 2007. e-Pub 2007. PMID: 16824611.
Goetzl L, Zighelboim I, Badell M, Rivers J, Mastrangèlo MA, Tweardy DJ, Suresh MS. Maternal corticosteroids to prevent intrauterine exposure to hyperthermia and inflammation: a randomized, double-blind, placebo-controlled trial. Am J Obstet Gynecol 195(4):1031-1037, 2006. e-Pub 2006. PMID: 16875647.
Tweardy DJ, Khoshnevis MR, Yu B, Mastrangelo MA, Hardison EG, López JA. Essential role for platelets in organ injury and inflammation in resuscitated hemorrhagic shock. Shock 26(4):386-390, 2006. e-Pub 2006. PMID: 16980886.
Qiu J, Wong J, Tweardy DJ, Dong S. Decreased intranuclear mobility of acute myeloid leukemia 1-containing fusion proteins is accompanied by reduced mobility and compartmentalization of core binding factor beta. Oncogene 25(28):3982-3993, 2006. e-Pub 2006. PMID: 16474840.
Shao H, Xu X, Jing N, Tweardy DJ. Unique structural determinants for Stat3 recruitment and activation by the granulocyte colony-stimulating factor receptor at phosphotyrosine ligands 704 and 744. J Immunol 176(5):2933-2941, 2006. e-Pub 2006. PMID: 16493051.
Arikan AA, Yu B, Mastrangelo MA, Tweardy DJ. Interleukin-6 treatment reverses apoptosis and blunts susceptibility to intraperitoneal bacterial challenge following hemorrhagic shock. Crit Care Med 34(3):771-777, 2006. e-Pub 2006. PMID: 16521270.
Jing N, Zhu Q, Yuan P, Li Y, Mao L, Tweardy DJ. Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancer. Mol Cancer Ther 5(2):279-286, 2006. e-Pub 2006. PMID: 16505101.
Yakub I, Lillibridge KM, Moran A, Gonzalez OY, Belmont J, Gibbs RA, Tweardy DJ. Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection. J Infect Dis 192(10):1741-1748, 2005. e-Pub 2005. PMID: 16235172.
Wehner S, Schwarz NT, Hundsdoerfer R, Hierholzer C, Tweardy DJ, Billiar TR, Bauer AJ, Kalff JC. Induction of IL-6 within the rodent intestinal muscularis after intestinal surgical stress. Surgery 137(4):436-446, 2005. e-Pub 2005. PMID: 15800492.
Vallejo JG, Nemoto S, Ishiyama M, Yu B, Knuefermann P, Diwan A, Baker JS, Defreitas G, Tweardy DJ, Mann DL. Functional significance of inflammatory mediators in a murine model of resuscitated hemorrhagic shock. Am J Physiol Heart Circ Physiol 288(3):H1272-H1277, 2005. e-Pub 2005. PMID: 15706046.
Brundage SI, Zautke NA, Holcomb JB, Spain DA, Lam JC, Mastrangelo MA, Macaitis JM, Tweardy DJ. Interleukin-6 infusion blunts proinflammatory cytokine production without causing systematic toxicity in a swine model of uncontrolled hemorrhagic shock. J Trauma 57(5):970-977; discussion 977-978, 2004. e-Pub 2004. PMID: 15580019.
Jing N, Li Y, Xiong W, Sha W, Jing L, Tweardy DJ. G-quartet oligonucleotides: a new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis. Cancer Res 64(18):6603-6609, 2004. e-Pub 2004. PMID: 15374974.
Ono M, Yu B, Hardison EG, Mastrangelo MA, Tweardy DJ. Increased susceptibility to liver injury after hemorrhagic shock in rats chronically fed ethanol: role of nuclear factor-kappa B, interleukin-6, and granulocyte colony-stimulating factor. Shock 21(6):519-525, 2004. e-Pub 2004. PMID: 15167680.
Dong S, Stenoien DL, Qiu J, Mancini MA, Tweardy DJ. Reduced intranuclear mobility of APL fusion proteins accompanies their mislocalization and results in sequestration and decreased mobility of retinoid X receptor alpha. Mol Cell Biol 24(10):4465-4475, 2004. e-Pub 2004. PMID: 15121864.
Shao H, Xu X, Mastrangelo MA, Jing N, Cook RG, Legge GB, Tweardy DJ. Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif. J Biol Chem 279(18):18967-18973, 2004. e-Pub 2004. PMID: 14966128.
Hierholzer C, Kalff JC, Billiar TR, Bauer AJ, Tweardy DJ, Harbrecht BG. Induced nitric oxide promotes intestinal inflammation following hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol 286(2):G225-G233, 2004. e-Pub 2004. PMID: 14715517.
Jing N, Li Y, Xu X, Sha W, Li P, Feng L, Tweardy DJ. Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells. DNA Cell Biol 22(11):685-696, 2003. e-Pub 2003. PMID: 14659041.
Brundage SI, Schreiber MA, Holcomb JB, Zautke N, Mastrangelo MA, Xq X, Macaitis J, Tweardy DJ. Amplification of the proinflammatory transcription factor cascade increases with severity of uncontrolled hemorrhage in swine. J Surg Res 113(1):74-80, 2003. e-Pub 2003. PMID: 12943813.
Shao H, Cheng HY, Cook RG, Tweardy DJ. Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor. Cancer Res 63(14):3923-3930, 2003. e-Pub 2003. PMID: 12873986.
Schreiber MA, Holcomb JB, Hedner U, Brundage SI, Macaitis JM, Aoki N, Meng ZH, Tweardy DJ, Hoots K. The effect of recombinant factor VIIa on non-coagulopathic pigs with grade V liver injuries. J Am Coll Surg 196(5):691-697, 2003. e-Pub 2003. PMID: 12742197.
Hierholzer C, Billiar TR, Tweardy DJ, Harbrecht B. Reduced hepatic transcription factor activation and expression of IL-6 and ICAM-1 after hemorrhage by NO scavenging. Arch Orthop Trauma Surg 123(2-3):55-59, 2003. e-Pub 2003. PMID: 12721681.
Kalff JC, Türler A, Schwarz NT, Schraut WH, Lee KK, Tweardy DJ, Billiar TR, Simmons RL, Bauer AJ. Intra-abdominal activation of a local inflammatory response within the human muscularis externa during laparotomy. Ann Surg 237(3):301-315, 2003. e-Pub 2003. PMID: 12616113.
Dong S, Qiu J, Stenoien DL, Brinkley WR, Mancini MA, Tweardy DJ. Essential role for the dimerization domain of NuMA-RARalpha in its oncogenic activities and localization to NuMA sites within the nucleus. Oncogene 22(6):858-868, 2003. e-Pub 2003. PMID: 12584566.
Dong S, Tweardy DJ. Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways. Blood 99(8):2637-2646, 2002. e-Pub 2002. PMID: 11929748.
Hierholzer C, Menezes JM, Ungeheuer A, Billiar TR, Tweardy DJ, Harbrecht BG. A nitric oxide scavenger protects against pulmonary inflammation following hemorrhagic shock. Shock 17(2):98-103, 2002. e-Pub 2002. PMID: 11837796.
Hierholzer C, Billiar TR, Tweardy DJ. Requirements for NF-kappaB activation in hemorrhagic shock. Arch Orthop Trauma Surg 122(1):44-47, 2002. e-Pub 2002. PMID: 11995880.
Shao H, Quintero AJ, Tweardy DJ. Identification and characterization of cis elements in the STAT3 gene regulating STAT3 alpha and STAT3 beta messenger RNA splicing. Blood 98(13):3853-3856, 2001. e-Pub 2001. PMID: 11739197.
Meng ZH, Dyer K, Billiar TR, Tweardy DJ. Essential role for IL-6 in post-resuscitation inflammation in hemorrhagic shock. Am J Physiol Cell Physiol 280(2):C343-C351, 2001. e-Pub 2001. PMID: 11208530.
Hierholzer C, Kalff JC, Chakraborty A, Watkins SC, Billiar TR, Bauer AJ, Tweardy DJ. Impaired gut contractility following hemorrhagic shock is accompanied by IL-6 and G-CSF production and neutrophil infiltration. Dig Dis Sci 46(2):230-241, 2001. e-Pub 2001. PMID: 11281168.
Hierholzer C, Harbrecht BG, Billiar TR, Tweardy DJ. Hypoxia-inducible factor-1 activation and cyclo-oxygenase-2 induction are early reperfusion-independent inflammatory events in hemorrhagic shock. Arch Orthop Trauma Surg 121(4):219-222, 2001. e-Pub 2001. PMID: 11317684.
Chakraborty A, Dyer KF, Tweardy DJ. Delineation and mapping of Stat5 isoforms activated by granulocyte colony-stimulating factor in myeloid cells. Blood Cells Mol Dis 26(4):320-330, 2000. e-Pub 2000. PMID: 11042034.
Meng ZH, Dyer K, Billiar TR, Tweardy DJ. Distinct effects of systemic infusion of G-CSF vs. IL-6 on lung and liver inflammation and injury in hemorrhagic shock. Shock 14(1):41-48, 2000. e-Pub 2000. PMID: 10909892.
Villavicencio RT, Liu S, Kibbe MR, Williams DL, Ganster RW, Dyer KF, Tweardy DJ, Billiar TR, Pitt BR. Induced nitric oxide inhibits IL-6-induced Stat3 activation and type II acute phase mRNA expression. Shock 13(6):441-445, 2000. e-Pub 2000. PMID: 10847630.
White SM, Alarcon MH, Tweardy DJ. Inhibition of granulocyte colony-stimulating factor-mediated myeloid maturation by low level expression of the differentiation-defective class IV granulocyte colony-stimulating factor receptor isoform. Blood 95(11):3335-3340, 2000. e-Pub 2000. PMID: 10828013.
Lou W, Ni Z, Dyer K, Tweardy DJ, Gao AC. Interleukin-6 induces prostate cancer cell growth accompanied by activation of Stat3 signaling pathway . Prostate 42(3):239-242, 2000. e-Pub 2000. PMID: 10639195.
Hierholzer C, Kalff JC, Audolfsson G, Billiar TR, Tweardy DJ, Bauer AJ. Molecular and functional contractile sequelae of rat intestinal ischemia/reperfusion injury. Transplantation 68(9):1244-1254, 1999. e-Pub 1999. PMID: 10573059.
Menezes J, Hierholzer C, Watkins SC, Lyons V, Peitzman AB, Billiar TR, Tweardy DJ, Harbrecht BG. A novel nitric oxide scavenger decreases liver injury and improves survival after hemorrhagic shock. Am J Physiol 277(1 Pt 1):G144-G151, 1999. e-Pub 1999. PMID: 10409161.
Kirkwood JM, Farkas DL, Chakraborty A, Dyer KF, Tweardy DJ, Abernethy JL, Edington HD, Donnelly SS, Becker D. Systemic interferon-alpha (IFN-alpha) treatment leads to Stat3 inactivation in melanoma precursor lesions. Mol Med 5(1):11-20, 1999. e-Pub 1999. PMID: 10072444.
Chakraborty A, Dyer KF, Cascio M, Mietzner TA, Tweardy DJ. Identification of a novel Stat3 recruitment and activation motif within the granulocyte colony-stimulating factor receptor. Blood 93(1):15-24, 1999. e-Pub 1999. PMID: 9864141.
Hierholzer C, Kalff JC, Bednarski B, Memarzadeh F, Kim YM, Billiar TR, Tweardy DJ. Rapid and simultaneous activation of Stat3 and production of interleukin 6 in resuscitated hemorrhagic shock. Arch Orthop Trauma Surg 119(5-6):332-336, 1999. e-Pub 1999. PMID: 10447634.
Chakraborty A, Tweardy DJ. Granulocyte colony-stimulating factor activates a 72-kDa isoform of STAT3 in human neutrophils. J Leukoc Biol 64(5):675-680, 1998. e-Pub 1998. PMID: 9823774.
Drenning SD, Marcovitch AJ, Johnson DE, Melhem MF, Tweardy DJ, Grandis JR. Bcl-2 but not Bax expression is associated with apoptosis in normal and transformed squamous epithelium. Clin Cancer Res 4(11):2913-2921, 1998. e-Pub 1998. PMID: 9829760.
Grandis JR, Drenning SD, Chakraborty A, Zhou MY, Zeng Q, Pitt AS, Tweardy DJ. Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro. J Clin Invest 102(7):1385-1392, 1998. e-Pub 1998. PMID: 9769331.
Hierholzer C, Kalff JC, Billiar TR, Bauer A, Tweardy DJ. Activation of STAT proteins following ischemia reperfusion injury demonstrates a distinct IL-6 and G-CSF mediated profile. Transplant Proc 30(6):2647, 1998. e-Pub 1998. PMID: 9745531.
Hierholzer C, Kalff JC, Omert L, Tsukada K, Loeffert JE, Watkins SC, Billiar TR, Tweardy DJ. Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury. Am J Physiol 275(3 Pt 1):L611-L621, 1998. e-Pub 1998. PMID: 9728057.
Grandis JR, Zeng Q, Drenning SD, Tweardy DJ. Normalization of EGFR mRNA levels following restoration of wild-type p53 in a head and neck squamous cell carcinoma cell line. Int J Oncol 13(2):375-378, 1998. e-Pub 1998. PMID: 9664135.
He Y, Zeng Q, Drenning SD, Melhem MF, Tweardy DJ, Huang L, Grandis JR. Inhibition of human squamous cell carcinoma growth in vivo by epidermal growth factor receptor antisense RNA transcribed from the U6 promoter. J Natl Cancer Inst 90(14):1080-1087, 1998. e-Pub 1998. PMID: 9672256.
Grandis JR, Melhem MF, Gooding WE, Day R, Holst VA, Wagener MM, Drenning SD, Tweardy DJ. Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival. J Natl Cancer Inst 90(11):824-832, 1998. e-Pub 1998. PMID: 9625170.
Gregory SH, Wing EJ, Danowski KL, van Rooijen N, Dyer KF, Tweardy DJ. IL-6 produced by Kupffer cells induces STAT protein activation in hepatocytes early during the course of systemic listerial infections. J Immunol 160(12):6056-6061, 1998. e-Pub 1998. PMID: 9637522.
White SM, Ball ED, Ehmann WC, Rao AS, Tweardy DJ. Increased expression of the differentiation-defective granulocyte colony-stimulating factor receptor mRNA isoform in acute myelogenous leukemia. Leukemia 12(6):899-906, 1998. e-Pub 1998. PMID: 9639418.
Grandis JR, Chakraborty A, Zeng Q, Melhem MF, Tweardy DJ. Downmodulation of TGF-alpha protein expression with antisense oligonucleotides inhibits proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells. J Cell Biochem 69(1):55-62, 1998. e-Pub 1998. PMID: 9513046.
Hierholzer C, Harbrecht B, Menezes JM, Kane J, MacMicking J, Nathan CF, Peitzman AB, Billiar TR, Tweardy DJ. Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock. J Exp Med 187(6):917-928, 1998. e-Pub 1998. PMID: 9500794.
Hierholzer C, Kelly E, Lyons V, Roedling E, Davies P, Billiar TR, Tweardy DJ. G-CSF instillation into rat lungs mediates neutrophil recruitment, pulmonary edema, and hypoxia. J Leukoc Biol 63(2):169-174, 1998. e-Pub 1998. PMID: 9468275.
Grandis JR, Tweardy DJ, Melhem MF. Asynchronous modulation of transforming growth factor alpha and epidermal growth factor receptor protein expression in progression of premalignant lesions to head and neck squamous cell carcinoma. Clin Cancer Res 4(1):13-20, 1998. e-Pub 1998. PMID: 9516947.
Hierholzer C, Kalff JC, Billiar TR, Tweardy DJ. Activation of STAT proteins in the lung of rats following resuscitation from hemorrhagic shock. Arch Orthop Trauma Surg 117(6-7):372-375, 1998. e-Pub 1998. PMID: 9709854.
Hierholzer C, Kelly E, Tsukada K, Loeffert E, Watkins S, Billiar TR, Tweardy DJ. Hemorrhagic shock induces G-CSF expression in bronchial epithelium. Am J Physiol 273(5 Pt 1):L1058-L1064, 1997. e-Pub 1997. PMID: 9374735.
Grandis JR, Chakraborty A, Melhem MF, Zeng Q, Tweardy DJ. Inhibition of epidermal growth factor receptor gene expression and function decreases proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells. Oncogene 15(4):409-416, 1997. e-Pub 1997. PMID: 9242377.
Perumal NB, Kenniston TW, Tweardy DJ, Dyer KF, Hoffman R, Peschon J, Appasamy PM. TCR-gamma genes are rearranged but not transcribed in IL-7R alpha-deficient mice. J Immunol 158(12):5744-5750, 1997. e-Pub 1997. PMID: 9190924.
Hierholzer C, Kelly E, Billiar TR, Tweardy DJ. Granulocyte colony-stimulating factor (G-CSF) production in hemorrhagic shock requires both the ischemic and resuscitation phase. Arch Orthop Trauma Surg 116(3):173-176, 1997. e-Pub 1997. PMID: 9061173.
Chakraborty A, White SM, Schaefer TS, Ball ED, Dyer KF, Tweardy DJ. Granulocyte colony-stimulating factor activation of Stat3 alpha and Stat3 beta in immature normal and leukemic human myeloid cells. Blood 88(7):2442-2449, 1996. e-Pub 1996. PMID: 8839834.
Grandis JR, Melhem MF, Barnes EL, Tweardy DJ. Quantitative immunohistochemical analysis of transforming growth factor-alpha and epidermal growth factor receptor in patients with squamous cell carcinoma of the head and neck. Cancer 78(6):1284-1292, 1996. e-Pub 1996. PMID: 8826952.
Morel BF, Burke MA, Kalagnanam J, McCarthy SA, Tweardy DJ, Morel PA. Making sense of the combined effect of interleukin-2 and interleukin-4 on lymphocytes using a mathematical model. Bull Math Biol 58(3):569-594, 1996. e-Pub 1996. PMID: 8688839.
Grandis JR, Zeng Q, Tweardy DJ. Retinoic acid normalizes the increased gene transcription rate of TGF-alpha and EGFR in head and neck cancer cell lines. Nat Med 2(2):237-240, 1996. e-Pub 1996. PMID: 8574972.
Tweardy DJ, Wright TM, Ziegler SF, Baumann H, Chakraborty A, White SM, Dyer KF, Rubin KA. Granulocyte colony-stimulating factor rapidly activates a distinct STAT-like protein in normal myeloid cells. Blood 86(12):4409-4416, 1995. e-Pub 1995. PMID: 8541528.
Prezioso JA, Wang J, Kim M, Duty L, Tweardy DJ, Gorelik E. Augmentation of TNF cytotoxicity by protein kinase C inhibitors: role of arachidonic acid and manganese superoxide dismutase. Cytokine 7(6):517-525, 1995. e-Pub 1995. PMID: 8580367.
Tkatch LS, Rubin KA, Ziegler SF, Tweardy DJ. Modulation of human G-CSF receptor mRNA and protein in normal and leukemic myeloid cells by G-CSF and retinoic acid. J Leukoc Biol 57(6):964-971, 1995. e-Pub 1995. PMID: 7540644.
Morel PA, Chang HJ, Wilson JW, Conte C, Falkner D, Tweardy DJ, Medsger TA. HLA and ethnic associations among systemic sclerosis patients with anticentromere antibodies. Hum Immunol 42(1):35-42, 1995. e-Pub 1995. PMID: 7751158.
Su GL, Freeswick PD, Geller DA, Wang Q, Shapiro RA, Wan YH, Billiar TR, Tweardy DJ, Simmons RL, Wang SC. Molecular cloning, characterization, and tissue distribution of rat lipopolysaccharide binding protein. Evidence for extrahepatic expression. J Immunol 153(2):743-752, 1994. e-Pub 1994. PMID: 8021509.
Morel PA, Chang HJ, Wilson JW, Conte C, Saidman SL, Bray JD, Tweardy DJ, Medsger TA. Severe systemic sclerosis with anti-topoisomerase I antibodies is associated with an HLA-DRw11 allele. Hum Immunol 40(2):101-110, 1994. e-Pub 1994. PMID: 7928439.
Corey SJ, Burkhardt AL, Bolen JB, Geahlen RL, Tkatch LS, Tweardy DJ. Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases. Proc Natl Acad Sci U S A 91(11):4683-4687, 1994. e-Pub 1994. PMID: 8197119.
Stewart-Akers AM, Cairns JS, Tweardy DJ, McCarthy SA. Granulocyte-macrophage colony-stimulating factor augmentation of T-cell receptor-dependent and T-cell receptor-independent thymocyte proliferation. Blood 83(3):713-723, 1994. e-Pub 1994. PMID: 8298134.
Steinman RA, Tweardy DJ. Granulocyte colony-stimulating factor receptor mRNA upregulation is an immediate early marker of myeloid differentiation and exhibits dysfunctional regulation in leukemic cells. Blood 83(1):119-127, 1994. e-Pub 1994. PMID: 8274731.
Kim M, Rao MV, Tweardy DJ, Prakash M, Galili U, Gorelik E. Lectin-induced apoptosis of tumour cells. Glycobiology 3(5):447-453, 1993. e-Pub 1993. PMID: 8286857.
Wang SC, Morel PA, Wang Q, Jordan ML, Simmons RL, Tweardy DJ. A dual mechanism of immunosuppression by FK-506. Differential suppression of IL-4 and IL-10 levels in T helper 2 cells. Transplantation 56(4):978-985, 1993. e-Pub 1993. PMID: 7692640.
Geller DA, Nguyen D, Shapiro RA, Nussler A, Di Silvio M, Freeswick P, Wang SC, Tweardy DJ, Simmons RL, Billiar TR. Cytokine induction of interferon regulatory factor-1 in hepatocytes. Surgery 114(2):235-242, 1993. e-Pub 1993. PMID: 7688150.
Grandis JR, Tweardy DJ. Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer. Cancer Res 53(15):3579-3584, 1993. e-Pub 1993. PMID: 8339264.
Stewart-Akers AM, Cairns JS, Tweardy DJ, McCarthy SA. Effect of granulocyte-macrophage colony-stimulating factor on lymphokine-activated killer cell induction. Blood 81(10):2671267-8, 1993. e-Pub 1993. PMID: 8490177.
Geller DA, Kispert PH, Su GL, Wang SC, Di Silvio M, Tweardy DJ, Billiar TR, Simmons RL. Induction of hepatocyte lipopolysaccharide binding protein in models of sepsis and the acute-phase response. Arch Surg 128(1):22-27; discussion 27-28, 1993. e-Pub 1993. PMID: 8418776.
Wang SC, Jordan ML, Tweardy DJ, Wright J, Hoffman RA, Simmons RL. FK-506 inhibits proliferation and IL-4 messenger RNA production by a T-helper 2 cell line. J Surg Res 53(2):199-202, 1992. e-Pub 1992. PMID: 1383612.
Gregory SH, Wing EJ, Tweardy DJ, Shadduck RK, Lin HS. Primary listerial infections are exacerbated in mice administered neutralizing antibody to macrophage colony-stimulating factor. J Immunol 149(1):188-193, 1992. e-Pub 1992. PMID: 1535085.
Tweardy DJ, Morel PA, Mott PL, Glazer EW, Zeh HJ, Sakurai M. Modulation of myeloid proliferation and differentiation by monoclonal antibodies directed against a protein that interacts with the interleukin-3 receptor. Blood 80(2):359-366, 1992. e-Pub 1992. PMID: 1378315.
Tweardy DJ, Anderson K, Cannizzaro LA, Steinman RA, Croce CM, Huebner K. Molecular cloning of cDNAs for the human granulocyte colony-stimulating factor receptor from HL-60 and mapping of the gene to chromosome region 1p32-34. Blood 79(5):1148-1154, 1992. e-Pub 1992. PMID: 1371413.
Morel PA, Walker JA, Livingstone AM, Tweardy DJ, Cairns JS. Proto-oncogene transcription after activation of Th-1 and Th-2 cells. Ann N Y Acad Sci 636:386-389, 1991. e-Pub 1991. PMID: 1838913.
Wang SC, Zeevi A, Jordan ML, Simmons RL, Tweardy DJ. FK 506, rapamycin, and cyclosporine: effects on IL-4 and IL-10 mRNA levels in a T-helper 2 cell line. Transplant Proc 23(6):2920-2922, 1991. e-Pub 1991. PMID: 1721312.
Tweardy DJ, Morel PA, Herberman RB, Sakurai M. Inhibition of growth of mouse leukemic cell lines in vitro and in vivo by a monoclonal antibody that recognizes an interleukin 3 receptor-associated protein. Cancer Res 51(16):4355-4359, 1991. e-Pub 1991. PMID: 1868459.
Tweardy DJ, Glazer EW, Mott PL, Anderson K. Modulation by tumor necrosis factor-alpha of human astroglial cell production of granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF). J Neuroimmunol 32(3):269-278, 1991. e-Pub 1991. PMID: 1709645.
Morel PA, Schreurs J, Townsend K, Gross M, Chiller JM, Tweardy DJ. Identification of a novel protein capable of interacting with the IL-3 receptor. J Immunol 146(7):2295-2304, 1991. e-Pub 1991. PMID: 2005398.
Ford HR, Hoffman RA, Tweardy DJ, Kispert P, Wang S, Simmons RL. Evidence that production of interleukin 6 within the rejecting allograft coincides with cytotoxic T lymphocyte development. Transplantation 51(3):656-661, 1991. e-Pub 1991. PMID: 2006523.
Wang SC, Tweardy DJ, Ford HR, Hoffman RA, Simmons RL. Cytokine products of T-helper 2 (Th2) cells are present in rejecting sponge matrix allografts. Transplant Proc 23(1 Pt 1):809-810, 1991. e-Pub 1991. PMID: 1824998.
Tweardy DJ, Sasaki M, Cardamone JJ, McCoy JP, Bonidie MJ, Signorella AP. Production of laminin B2 chain protein and messenger RNA by a murine neutrophil precursor cell line, 32Dc13. Blood 76(7):1398-1404, 1990. e-Pub 1990. PMID: 1698480.
Tweardy DJ, Mott PL, Glazer EW. Monokine modulation of human astroglial cell production of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor. I. Effects of IL-1 alpha and IL-beta. J Immunol 144(6):2233-2241, 1990. e-Pub 1990. PMID: 1690240.
Sriwanthana B, Hemachudha T, Griffin DE, Manutsathit S, Tweardy DJ, Phanuphak P. Lymphocyte subsets in human encephalitic and paralytic rabies. Acta Neurol Scand 80(4):287-289, 1989. e-Pub 1989. PMID: 2816284.
Tweardy DJ, Cannizzaro LA, Palumbo AP, Shane S, Huebner K, Vantuinen P, Ledbetter DH, Finan JB, Nowell PC, Rovera G. Molecular cloning and characterization of a cDNA for human granulocyte colony-stimulating factor (G-CSF) from a glioblastoma multiforme cell line and localization of the G-CSF gene to chromosome band 17q21. Oncogene Res 1(3):209-220, 1987. e-Pub 1987. PMID: 2453015.
Rich EA, Tweardy DJ, Fujiwara H, Ellner JJ. Spectrum of immunoregulatory functions and properties of human alveolar macrophages. Am Rev Respir Dis 136(2):258-265, 1987. e-Pub 1987. PMID: 2956914.
Valtieri M, Tweardy DJ, Caracciolo D, Johnson K, Mavilio F, Altmann S, Santoli D, Rovera G. Cytokine-dependent granulocytic differentiation. Regulation of proliferative and differentiative responses in a murine progenitor cell line. J Immunol 138(11):3829-3835, 1987. e-Pub 1987. PMID: 2438328.
Valtieri M, Santoli D, Caracciolo D, Kreider BL, Altmann SW, Tweardy DJ, Gemperlein I, Mavilio F, Lange B, Rovera G. Establishment and characterization of an undifferentiated human T leukemia cell line which requires granulocyte-macrophage colony stimulatory factor for growth. J Immunol 138(11):4042-4050, 1987. e-Pub 1987. PMID: 2953797.
Tweardy DJ, Osman GS, el Kholy A, Ellner JJ. Failure of immunosuppressive mechanisms in human Schistosoma mansoni infection with hepatosplenomegaly. J Clin Microbiol 25(5):768-773, 1987. e-Pub 1987. PMID: 2953755.
Salata RA, Lederman MM, Shlaes DM, Jacobs MR, Eckstein E, Tweardy DJ Toossi Z, Chmielewski R, Marino J, King CH. Diagnosis of nosocomial pneumonia in intubated, intensive care unit patients. Am Rev Respir Dis 135(2):426-432, 1987. e-Pub 1987. PMID: 3101559.
Tweardy DJ, Caracciolo D, Valtieri M, Rovera G. Tumor-derived growth factors that support proliferation and differentiation of normal and leukemic hemopoietic cells. Ann N Y Acad Sci 511:30-38, 1987. e-Pub 1987. PMID: 2830826.
Tweardy DJ, Fujiwara H, Scillian JJ, Ellner JJ. Concurrent enhancement of monocyte immunoregulatory properties and effector functions by recombinant interferon-gamma. Cell Immunol 100(1):34-46, 1986. e-Pub 1986. PMID: 2943410.
Santoli D, Tweardy DJ, Ferrero D, Kreider BL, Rovera G. A suppressor lymphokine produced by human T leukemia cell lines. Partial characterization and spectrum of activity against normal and malignant hemopoietic cells. J Exp Med 163(1):18-40, 1986. e-Pub 1986. PMID: 2416868.
Tweardy DJ. Relapsing toxic shock syndrome in the puerperium. JAMA 253(22):3249-3250, 1985. e-Pub 1985. PMID: 3999307.
Croce CM, Isobe M, Palumbo A, Puck J, Ming J, Tweardy DJ, Erikson J, Davis M, Rovera G. Gene for alpha-chain of human T-cell receptor: location on chromosome 14 region involved in T-cell neoplasms. Science 227(4690):1044-1047, 1985. e-Pub 1985. PMID: 3919442.
Ellner JJ, Tweardy DJ, Osman GS, Wilson C, El Kholy A, Rocklin RE. Increased blastogenic responses to worm antigen and loss of adherent suppressor cell activity after treatment for human infection with Schistosoma mansoni. J Infect Dis 151(2):320-324, 1985. e-Pub 1985. PMID: 3155782.
Shlaes DM, Lederman MM, Chmielewski R, Tweardy DJ, Krause G, Saffai C. Sputum elastin fibers and the diagnosis of necrotizing pneumonia. Chest 85(6):763-766, 1984. e-Pub 1984. PMID: 6723386.
Tweardy DJ, Schacter BZ, Ellner JJ. Association of altered dynamics of monocyte surface expression of human leukocyte antigen DR with immunosuppression in tuberculosis. J Infect Dis 149(1):31-37, 1984. e-Pub 1984. PMID: 6607294.
Tweardy DJ, Fujiwara H, Ellner JJ. Enhancement of monocyte immunoregulatory properties and effector functions by recombinant interferon-gamma. Trans Assoc Am Physicians 97:353-364, 1984. e-Pub 1984. PMID: 6442952.
Tweardy DJ, Jacobs MR, Speck WT. Susceptibility of penicillin-resistant pneumococci to eighteen antimicrobials: implications for treatment of meningitis. J Antimicrob Chemother 12(2):133-139, 1983. e-Pub 1983. PMID: 6555189.
Shlaes DM, Lederman M, Chmielewski R, Tweardy DJ, Wolinsky E. Elastin fibers in the sputum of patients with necrotizing pneumonia. Chest 83(6):885-889, 1983. e-Pub 1983. PMID: 6851690.
Tweardy DJ, Osman GS, El Kholy A, Ellner JJ. Abnormalities of immunosuppression in patients with hepatosplenic schistosomiasis mansoni. Trans Assoc Am Physicians 96:392-400, 1983. e-Pub 1983. PMID: 6238469.

Invited Articles

Tweardy DJ, Chang JC. Stat5: from breast development to cancer prognosis, prediction, and progression. J Clin Oncol 29(18):2443-4, 2011. e-Pub 2011. PMID: 21576641.
Diaz FL, Tweardy DJ, Shellock FG. Cervical external immobilization devices: evaluation of magnetic resonance imaging issues at 3.0 Tesla. Spine (Phila Pa 1976) 35(4):411-5, 2010. e-Pub 2010. PMID: 20110847.
Tweardy DJ, Belmont JW. "Personalizing" academic medicine: opportunities and challenges in implementing genomic profiling. Transl Res 154(6):288-94, 2009. e-Pub 2009. PMID: 19931194.
Ivancic PC, Beauchman NN, Tweardy DJ. Effect of halo-vest components on stabilizing the injured cervical spine. Spine (Phila Pa 1976) 34(2):167-75, 2009. e-Pub 2009. PMID: 19139667.
Weerasinghe P, Li Y, Guan Y, Zhang R, Tweardy DJ, Jing N. T40214/PEI complex: a potent therapeutics for prostate cancer that targets STAT3 signaling. Prostate 68(13):1430-42, 2008. e-Pub 2008. PMID: 18615483.
Trautner BW, Cevallos ME, Li H, Riosa S, Hull RA, Hull SI, Tweardy DJ, Darouiche RO. Increased expression of type-1 fimbriae by nonpathogenic Escherichia coli 83972 results in an increased capacity for catheter adherence and bacterial interference. J Infect Dis 198(6):899-906, 2008. e-Pub 2008. PMID: 18643750.
Qiu J, Huang Y, Chen G, Chen Z, Tweardy DJ, Dong S. Aberrant chromatin remodeling by retinoic acid receptor alpha fusion proteins assessed at the single-cell level. Mol Biol Cell 18(10):3941-51, 2007. e-Pub 2007. PMID: 17671166.
Tweardy DJ, Jing N. Enhancing or eliminating signals for cell survival to treat disease. Trans Am Clin Climatol Assoc 117:33-51; discussion 51-2, 2006. e-Pub 2006. PMID: 18528463.
Redell MS, Tweardy DJ. Targeting transcription factors in cancer: Challenges and evolving strategies. Drug Discov Today Technol 3(3):261-7, 2006. e-Pub 2006. PMID: 24980527.
Jing N, Tweardy DJ. Targeting Stat3 in cancer therapy. Anticancer Drugs 16(6):601-7, 2005. e-Pub 2005. PMID: 15930886.
Redell MS, Tweardy DJ. Targeting transcription factors for cancer therapy. Curr Pharm Des 11(22):2873-87, 2005. e-Pub 2005. PMID: 16101443.
Jing N, Sha W, Li Y, Xiong W, Tweardy DJ. Rational drug design of G-quartet DNA as anti-cancer agents. Curr Pharm Des 11(22):2841-54, 2005. e-Pub 2005. PMID: 16101441.
Dong S, Chen SJ, Tweardy DJ. Cross-talk between retinoic acid and STAT3 signaling pathways in acute promyelocytic leukemia. Leuk Lymphoma 44(12):2023-9, 2003. e-Pub 2003. PMID: 14959844.
Kim LJ, Sonntag VK, Hott JT, Nemeth JA, Klopfenstein JD, Tweardy DJ. Scalp burns from halo pins following magnetic resonance imaging. Case illustration. J Neurosurg 99(1):186, 2003. e-Pub 2003. PMID: 12854765.
Hierholzer C, Kalff JC, Bauer A, Billiar TR, Tweardy DJ. Production of G-CSF and IL-6 and activation of STAT proteins in mucosa and muscularis in the jejunum in hemorrhagic shock. Langenbecks Arch Chir:579-583, 1997. e-Pub 1997.
Hierholzer C, Menezes J, Kalff JC, Harbrecht, Billiar TR, Tweardy DJ. Treatment with the iNOS inhibitor L-N-6-(1-iminoehyl)lysine (L-NIL) attenuates the inflammatory response caused by resuscitated hemorrhagic shock. Surg Forum 48:108-110, 1997. e-Pub 1997.
Hierholzer C, Kelly E, Billiar TR, Tweardy DJ. Granulocyte colony-stimulating factor (G-CSF) production and neutrophil activation in hemorrhagic shock. Langenbeck Arch Chir Suppl 1:15-19, 1996. e-Pub 1996.
Hierholzer C, Kalff JC, Omert L, Billiar TR, Tweardy DJ. G-CSF and IL-6 are produced in the lung in hemorrhagic shock where they contribute to the recruitment and activation of neutrophils. Proceedings of the Fourth International Congress on the Immunological Consequences of Trauma, Sepsis and Shock:595-599, 1996. e-Pub 1996.
Hierholzer C, Kelly E, Lyons V, Billiar TR, Tweardy DJ. Granulocyte colony-stimulating factor (G-CSF) instillation into the lung results in neutrophils recruitment and lung damage. Surg Forum 47:118-120, 1996. e-Pub 1996.
Geller DA, Wang SC, Di Silvio M, Nussler A, Bloomgarden G, Tweardy DJ, Billiar TR, Simmons RL. Interferon regulatory factor gene expression is induced in hepatocytes in models of sepsis. Surg Forum 43:102-104, 1992. e-Pub 1992.
Wang SC, Geller DA, Su GL, Wan YH, Shapiro RA, Tweardy DJ, Billiar TR, Simmons RL. Regulation of lipopolysaccharide binding protein (LBP) gene transcription in rat hepatocytes. Surg Forum 43:169-171, 1992. e-Pub 1992.
Wang SC, Tweardy DJ, Ford HR, Hoffman RA, Simmons RL. Rapid identification of T helper 2 cells by message amplification phenotyping. Surg Forum 41, 1991. e-Pub 1991.
Wang SC, Zeevi A, Simmons RL, bTweardy DJ. IL-10 (cytokine synthesis inhibitory factor) mRNA is detectable by reverse-transcription-polymerase chain reaction (RT-PCR) in sponge matrix allografts. Surg Forum 42:386-388, 1991. e-Pub 1991.
Tweardy DJ, Osman GS, El Kholy A, Ellner JJ. Abnormalities of immunosuppressive mechanism in patients with hepatosplenic Schistosoma mansoni infection. Trans Assoc Amer Phys 96:392-400, 1983. e-Pub 1983.
Tweardy DJ, Ellner JJ. Altered expression of monocyte surface Ia antigen in tuberculosis. U.S.-Japan Cooperative Medical Science Program:321-333, 1981. e-Pub 1981.

Review Articles

Kasembeli, MM, Rodas, J, Tweardy, D. Update on Structure and Function of SH2 Domains. International journal of molecular sciences 26(18), 2025. e-Pub 2025. PMID: 41009621.
Bharadwaj U, Kasembeli MM, Robinson P, Tweardy DJ. Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution. Pharmacol Rev 72(2):486-526, 2020. e-Pub 2020. PMID: 32198236.
Kasembeli MM, Bharadwaj U, Robinson P, Tweardy DJ. Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment. Int J Mol Sci 19(8), 2018. e-Pub 2018. PMID: 30081609.
Roh SH, Kasembeli M, Bakthavatsalam D, Chiu W, Tweardy DJ. Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis. Int J Mol Sci 16(11):26706-26720, 2015. e-Pub 2015. PMID: 26561808.
Bocchini CE, Kasembeli MM, Roh SH, Tweardy DJ. Contribution of chaperones to STAT pathway signaling. JAK-STAT 3(3):e970459, 2014. e-Pub 2014. PMID: 26413421.
Kasembeli MM, Xu X, Tweardy DJ. SH2 domain binding to phosphopeptide ligands: potential for drug targeting. Front Biosci (Landmark Ed) 14:1010-1022, 2009. e-Pub 2009. PMID: 19273114.
Chakraborty A, Tweardy DJ. STAT3 and G-CSF-induced myeloid differentiation. Leuk Lymphoma 30(5-6):433-442, 1998. e-Pub 1998. PMID: 9711905.
Lai CF, Morella KK, Wang Y, Kumaki S, Gearing D, Ziegler SF, Tweardy DJ, Campos SP, Baumann H. Function of hematopoietin receptor subunits in hepatic cells and fibroblasts. Ann N Y Acad Sci 762:189-205; discussion 206, 1995. e-Pub 1995. PMID: 7545363.
Tkatch LS, Tweardy DJ. Human granulocyte colony-stimulating factor (G-CSF), the premier granulopoietin: biology, clinical utility, and receptor structure and function. Lymphokine Cytokine Res 12(6):477-488, 1993. e-Pub 1993. PMID: 7510132.
Grandis JR, Tweardy DJ. TGF-alpha and EGFR in head and neck cancer. J Cell Biochem Suppl 17F:188-191, 1993. e-Pub 1993. PMID: 8412192.
Grandis JR, Tweardy DJ. The role of peptide growth factors in head and neck carcinoma. Otolaryngol Clin North Am 25(5):1105-1115, 1992. e-Pub 1992. PMID: 1408194.
Rovera G, Tweardy DJ, Santoli D, Altmann S, Valtieri M, Lange B. Proliferation and differentiation of human myelogenous leukemia and preleukemia cells in culture: identification of stimulatory and suppressor growth factors. Haematologica 72(6 Suppl):104-110, 1987. e-Pub 1987. PMID: 3127285.

Abstracts

Redell M, Tsimelzon A, Hilsenbeck SG, Tweardy DJ. Overexpression of Stat3-alpha, but not Stat3-beta, in myeloid cells results in neutrophil expansion through reduced apoptosis and modulation of a unique set of apoptosis pathway genes. Blood 108:A1147, 2006. e-Pub 2006.
Tweardy DJ, Huang Y. Stat3 isoforms, alpha and beta, demonstrate distinct intracellular dynamics: Prolonged nuclear retention of Stat3-beta maps to its unique C-terminal end. Blood 108:A4348, 2006. e-Pub 2006.
Tweardy DJ, Qiu J, Huang Y, Dong S. Aberrant chromatin remodeling by APL fusion proteins assessed at the single-cell level: Contribution of reduced mobility of nuclear coregulators. Blood 108:A2069, 2006. e-Pub 2006.
Moran A, Mastrangelo MA, Yu B, Wu Y, Tweardy DJ. Hemorrhagic shock-induced lung apoptosis: Requirement for resuscitation, dependence on duration of hypotension and complete reversal by IL-6-mediated activation of STAT3. Shock 25(Suppl):P117, 2006. e-Pub 2006.
Alten JA, Mastrangelo MA, Yu B, Wu Y, Hilsenbeck SG, Tweardy DJ. Anti-apoptotic genes modulated within the hearts of rats following successful IL-6 resuscitation from hemorrhagic shock: Not the usual suspects. Shock 23(Suppl):19, 2005. e-Pub 2005.
Arikan AA, Yu B, Mastrangelo MA, Tweardy DJ. Blunting of hemorrhagic shock (HS) induced susceptibility to intraperitoneal bacterial challenge by IL-6 s accompanied by reversal of HS-induced organ apoptosis. Shock 23(Suppl):P37, 2005. e-Pub 2005.
Tweardy DJ, Alten JA, Mastrangelo MA, Yu B, Wu Y, Hilsenbeck SG. Reversal of hypovolemic circulatory collapse and apoptotic pathway gene induction by interleukein (IL)-6. Circulation 110:1100, 2004. e-Pub 2004.
Zautke NA, Lam JC, Holcomb JB, Spain DA, Tweardy DJ, Brundage SI. TNF-alpha levels do not increase in ileum in a swine model of uncontrolled hemorrhage. Shock 21(Suppl):152, 2004. e-Pub 2004.
Tweardy DJ. Reversal of hypovolemic circulatory collapse and cardiac apoptosis through IL-6-mediated activation of STAT3. Shock 21(Suppl):71, 2004. e-Pub 2004.
Dong S, Stenoien DL, Qui J, Mancini MA, Tweardy DJ. Reduced nuclear mobility of APL fusion proteins (X-RAR-alpha) compared to RAR-alpha: Contribution of X and mapping in NuMA-RAR-alpha to the NuMA coiled-coil domain. Blood 102:610A, 2003. e-Pub 2003.
Jing N, Li Y, Xu X, Li P, Feng L, Tweardy DJ. Inhibition of Stat3 activity by G-quartet oligodeoxynucleotides. Proceedings of the American Association for Cancer Research 44:101, 2003. e-Pub 2003.
Shao H, Jing N, Tweardy DJ. Structural requirements for design of peptidomimetics targeting Stat3 activation by the EGFR. Proceedings of the American Association for Cancer Research 44:794, 2003. e-Pub 2003.
Shao H, Tweardy DJ. Structural requirements for Stat3 recruitment to phosphotyrosine motifs within signaling complexes. Blood 100:210B, 2002. e-Pub 2002.
Jing N, Li Y, Li P, Feng L, Tweardy DJ. Inhibition of Stat3 activity by G-quartet oligodeoxynucleotides. Blood 100:194A, 2002. e-Pub 2002.
Dong S, Stenoien DL, Mancini MA, Tweardy DJ. PML-RAR-alpha sequesters RXR-alpha within the nucleus distinct from RAR-alpha and reduces RXR-alpha intranuclear mobility in live cells. Blood 100:529A, 2002. e-Pub 2002.
Dong S, Qiu J, Patel K, Brinkley WR, Mancini MA, Tweardy DJ. The coiled-coil domain of NuMA-RAR-alpha is essential for its oncogenic activities and localization to NuMA sites within the nucleus. Blood 98:559A, 2001. e-Pub 2001.
Shao H, Tweardy DJ. Inhibition of Stat3 recruitment and activation by YXXQ-containing phospho-dodecapeptides: Contribution of Stat3 SH2 residues that interact with the +3 Q residue. Blood 98:573A, 2001. e-Pub 2001.
Dong S, Tweardy DJ. Interactions of the novel APL fusion protein, Stat5B-RAR-alpha, with SMRT, TRAM-1 and multiple myeloid signaling pathways: retinoic acid resistance may involce modulation of Stat5- and Stat3-dependent transcriptional activities. Blood 96:457A, 2000. e-Pub 2000.
Shao, H, Cascio M, Tweardy DJ. Identification and characterization of cis elements within the Stat3 gene regulatins Stat3-alpha and Stat3-beta mRNA ratios. Blood 96:93A, 2000. e-Pub 2000.
White SM, Alarcon MH, Tweardy DJ. Expression of the differentiation-defective human myeloid cells blocks G-CSF-mediated maturation. Blood 94:592A, 1999. e-Pub 1999.
Chakraborty A, Alarcon MH, White SM, Tweardy DJ. Overexpression of Stat3-alpha delays granulocyte colony-stimulating factor-mediated differentiation of myeloid cells. Blood 94:471A, 1999. e-Pub 1999.
Hierholzer C, Kalff JC, Taylor B, Stadler J, Billiar TR, Tweardy DJ. Stat3 is rapidly activated in the liver during hemorrhagic shock and demonstrates an isoform profile characteristic of G-CSF and IL-6. Hepatology, 1998. e-Pub 1998.
Hierholzer C, Kalff JC, Ungeheuer A, Billiar TR, Tweardy DJ. Activation of Stat3 in hemorrhagic shock requires both the ischemic and resuscitation phase. Hepatology, 1998. e-Pub 1998.
Hierholzer C, Kalff JC, Schraut WH, Billiar TR, Tweardy DJ, Bauer AJ. aoperative upregulation of muscularis IL-6, Stat3 activation and an association between neutrophil infiltration and muscle dysfunction in human. Gastroenterology, 1998. e-Pub 1998.
Kalff JC, Hierholzer C, Schraut WH, Billiar TR, Tweardy DJ, Bauer AJ. Abdominal surgery results in early STAT protein activation within the rat intestinal muscularis. Gastroenterology, 1998. e-Pub 1998.
Hierholzer C, Kalff J, Omert L, Bauer AJ, Billiar TR, Tweardy DJ. Activation of STAT proteins following ischemia reperfusion injury demonstrates a distinct IL-6 and G-CSF mediated profile. Transplantation Proceedings, 1998. e-Pub 1998.
Hierholzer C, Kalff J, Omert L, Bauer AJ, Billiar TR, Tweardy DJ. Differential production of cytokines, G-CSF and IL-6, and activation of STAT proteins in gut mucosa and muscularis in hemorrhagic shock. Shock 7:35, 1997. e-Pub 1997.
Hierholzer C, Kalff JC, Billiar TR, Tweardy DJ, Bauer AJ. Impairment of gut motility following ischemia/reperfusion is accompanied by production of G-CSF and IL-6, Stat3 activation and leukocyte recruitment. Gastroenterology 112:A747, 1997. e-Pub 1997.
Grandis JR, Chakraborty A, Pitt AS, Tweardy DJ. Activation of Stat3-alpha/beta by transforming growth factor alpha (TGF-alpha) and epidermal growth factor (EGF) in head and neck cancer cell lines. Proc. American Association for Cancer Research 38:374, 1997. e-Pub 1997.
Hierholzer C, Kalff JC, Omert L, Billiar TR, Tweardy DJ. G-CSF and IL-6 are produced in the lung in hemorrhagic shock where they contribute to the recruitment and activation of neutrophils. Shock 7((Supplement)):56, 1997. e-Pub 1997.
Tweardy DJ, Dyer KF, Chakraborty A. Repertoire and mapping of STAT proteins activated by G-CSFR in normal and neoplastic cells. Proceedings of an AACR Special Conference on Cell Signaling and Cancer Treatment, 1997. e-Pub 1997.
Hierholzer C, Kelly E, Billiar TR, Tweardy DJ. Granulocyte colony-stimulating factor (G-CSF) production and neutrophil activation in hemorrhagic shock. Shock, 1996. e-Pub 1996.
Grandis JR, Melhem MF, Wagener MM, Tweardy DJ. Decreased survival in patients with head and neck cancer who demonstrate elevated expression of transforming growth factor alpha (TGF-alpha) and epidermal growth factor receptor (EGFR). Proc. American Association for Cancer Research 37:198, 1996. e-Pub 1996.
Tweardy DJ, Ball ED, Chakraborty A. G-CSF activation of distinct STAT proteins in normal vs. leukemic human myeloid cells. Blood 86:605, 1995. e-Pub 1995.
White SM, Ball ED, Tweardy DJ. Increased expression of the differentiation-defective granulocyte colony-stimulating factor receptor mRNA isoform in acute myelogenous leukemia. Blood 86:83A, 1995. e-Pub 1995.
Tweardy DJ, Corey SJ, Wright TM, Ziegler SF, Baumann H. STAT protein activation by G-CSF in hematopoietic cells. Blood 84:223A, 1994. e-Pub 1994.
Su GL, Wang S, Wang Q, Shapiro R, Freeswick P, Geller D, Billiar T, Tweardy DJ, Simmons RL. Cloning and characterization of rat hepatocyte lipopolysaccharide binding protein (LBP). Gastroenterology:A100, 1993. e-Pub 1993.
Steinman RA, Anderson SM, Matulonis U, Tweardy DJ. Oncogene-mediated suppression of granulocyte colony-stimulating factor receptor (G-CSFR) mRNA expression. Blood 82:234A, 1993. e-Pub 1993.
Corey SJ, Burckhardt A, Bolen J, Geahlen R, Stephens L, Tweardy DJ. G-CSF receptor signaling involves formation of a three component complex with Lyn and Syk protein tyrosine kinases. Blood 82:439A, 1993. e-Pub 1993.
Wan YH, Wang SC, Su GL, Geller DA, Tweardy DJ, Kispert PH, Billiar TR, Simmons RL. Cytokine regulation of lipopolysaccharide binding protein mRNA in primary hepatocyte cultures. Hepatology 16:156A, 1992. e-Pub 1992.
Tkatch LS, Tweardy DJ. Human granulocyte colony-stimulating factor (G-CSF) modulates mRNA levels of its own receptor. Clin Res 40:340A, 1992. e-Pub 1992.
Corey SJ, Agarwal M, Steinman RA, Tkatch L, Bolen JB, Tweardy DJ. G-CSF stimulates the autophosphorylation of Src-related p53/p56 Lyn in human neutrophils and in 32Dcl3 cells, an IL-3 and G-CSF-responsive murine cell line. Blood, 1992. e-Pub 1992.
Su GL, Wang SC, Geller DA, Wang Q, Simmons RL, Billiar TR, Tweardy DJ. Molecular cloning of rat lipopolysaccharide binding protein. J Cell Biochem 16c:162, 1992. e-Pub 1992.
Steinman RA, Tweardy DJ. Regulation of G-CSFR mRNA expression in normal and leukemia cell lines. J Cell Biochem, 1992. e-Pub 1992.
Tweardy DJ, Steinman RA, Tkatch LS, Bolen JB, Corey SJ. Granulocyte colony-stimulating factor (G-CSF) induces autophosphorylation of Lyn in human neutrophils and in 32Dcl3, an IL-3 and G-CSF-responsive murine cell line. J Leuk Biol Supplement 3:A221, 1992. e-Pub 1992.
Grandis GR, Tweardy DJ. Aberrant transcription of epidermal growth factor receptor (EGFR) and transforming growth factor alpha (TGF-alpha) genes is an early marker of carcinogenesis in squamous cell carcinoma of the head and neck (SCCHN). Proc. American Association for Cancer Research 33:498, 1992. e-Pub 1992.
Morel PA, Chang HJ, Tweardy DJ, Medsger TA. Systemic sclerosis with diffuse scleroderma is associated with DRB1* 1104. Arthritis and Rheum, 1991. e-Pub 1991.
Morel PA, Chang HJ, Tweardy DJ, Medsger TA. The diffuse form of scleroderma is associated with DR131* 1104. Hum Immunol, 1991. e-Pub 1991.
Morel PA, Chang HJ, Tweardy DJ, Medsger TA. HLA associations in scleroderma patients with either anti-centromere antibodies or antibodies to the Sc170 antigen. J Cell Biochem, 1991. e-Pub 1991.
Tweardy DJ, Anderson K, Cannizzaro LA, Steinman RA, Croce CM, Huebner K. Molecular cloning of cDNAs for the human granulocyte colony-stimulating factor receptor from HL-60 and mapping of the gene to chromosome region 1p32-33. J Leuk Biol Supplement 2:98, 1991. e-Pub 1991.
Grandis JR, Tweardy DJ, Whiteside TL. Increased production of epidermal growth factor receptor and its ligand, transforming growth factor alpha (TGF-a) in squamous cell carcinoma of the head and neck (SCCHN): Support for an autocrine growth pathway. Otolaryngol Head Neck Surg, 1991. e-Pub 1991.
Tweardy DJ, Sakurai M, Schreurs J, Safaeian M, Chiller JM, Morel PA. Characterization and cloning of a novel hemopoietin receptor-associated protein. Int J of Cell Cloning 9:385, 1991. e-Pub 1991.
Mott PM, Conrad JA, Tweardy DJ. Identification and characterization of genes specifically induced by granulocyte colony-stimulating factor (G-CSF) during early neutrophilic differentiation. Clin Res 38:324A, 1990. e-Pub 1990.
Steude B, Brown KK, Tweardy DJ. Identification of candidate genes specifically induced by interleukin-3 (IL-3) during myeloid proliferation. Clin Res 38:541A, 1990. e-Pub 1990.
Stewart AM, Tweardy DJ, Cairns JS. Granulocyte-macrophage colony-stimulating factor augments interleukin-2-induced lymphokine activated killer cell activity. Clin Res 38:552, 1990. e-Pub 1990.
Wang SC, Jordan ML, Tweardy DJ, Hoffman RA, Wright J, Starzl TE, Simmons RL. FK-506 inhibits proliferation and IL-4 production by a T-helper 2 cell line. J Surg Res, 1990. e-Pub 1990.
Mott PM, Morel PA, Glazer EW, Tweardy DJ. Modulation of myeloid proliferation and differentiation by monoclonal antibodies directed against an interleukin-3 (IL-3) binding protein. Clin Res 37:384A, 1989. e-Pub 1989.
Stewart AM, Tweardy DJ, Cairns JS. The effect of granulocyte-macrophage colony-stimulating factor on thymocyte proliferation. Clin Res 37:420A, 1989. e-Pub 1989.
Tweardy DJ, Mott PL, Morel PA. The effects of two rat monoclonal antibodies directed against and IL-3 binding protein on the IL-3-induced proliferation and G-CSF-induced proliferation and differentiation of 32Dc13. J Cell Biochem S13C:19, 1989. e-Pub 1989.
Tweardy DJ, Mott PM. Identification of candidate genes specifically induced by granulocyte colony-stimulating factor (G-CSF) during early neutrophilic differentiation. J Leuk Biol 46:292, 1989. e-Pub 1989.
Morel PA, Townsend K, Gross M, Tweardy DJ, Chiller J. Monoclonal antibodies to an IL-3-binding protein on murine mast cells. J Cell Biochem S13C:29, 1989. e-Pub 1989.
Tweardy DJ, Mavilio F, Glazer EW, Hanley KA, McCoy JP. Production and surface expression of a laminin-like protein during granulocyte differentiation. Clin Res 36:421A, 1988. e-Pub 1988.
Tweardy DJ, Glazer EW. Monokine modulation of human neuroglial cell production of G-CSF and GM-CSF. Clin Res 36:474A, 1988. e-Pub 1988.
Tweardy DJ, Huebner K, Palumbo AB, Valtieri M, Caracciolo D, Shane S, Rovera G. Molecular cloning and characterization of a cDNA for granulocyte colony-stimulating factor (G-CSF) from U87MG, a glioblastoma multiform cell line and mapping of the G-CSF gene to chromosome 17. Clin Res 35:433A, 1987. e-Pub 1987.
Tweardy DJ, Santoli D, Rovera G. T-leukemia derived suppressor lymphokine (TLSL): Biology and Biochemistry. J Cell Biochem Supplement 10A:91, 1986. e-Pub 1986.
Tweardy DJ, Santoli D, Dietzschold B, Wheelock MJ, Altmann SW, Rovera G. T-leukemia derived suppressor lymphokine (TLSL): Biochemical characterization, partial sequencing and cloning. Clin Res 34:296A, 1986. e-Pub 1986.
Santoli D, Tweardy DJ, Rovera G. Spectrum of activity of T-leukemia derived suppressor lymphokine (TLSL) against normal and malignant cell lines of human and non-human origin. Clin Res 34:296A, 1986. e-Pub 1986.
Tweardy DJ, Santoli D, Rovera G. Purification to homogeneity of a suppressor lymphokine (SLK-A) produced by Jurkat, a human T-leukemia cell line. Clin Res 33:390A, 1985. e-Pub 1985.
Tweardy DJ, Santoli D, Rovera G. Identification of two distinct suppressor lymphokines (SLK-A and SLK-B) produced by human T-cell lines. Clin Res 33:390A, 1985. e-Pub 1985.
Tweardy DJ, Fujiwara, Ellner JJ. Dissociation of monocyte immunoregulatory and effector function by density separation. Clin Res 33:389A, 1985. e-Pub 1985.
Tweardy DJ. Relapsing toxic shock syndrome in the pueperium. JAMA 253:3249-3250, 1985. e-Pub 1985.
Tweardy DJ, Blades EW, Ellner JJ. Concurrent enhancement of monocyte immunoregulatory and effector functions by recombinant interferon-alpha. Clin Res 32:559A, 1984. e-Pub 1984.
Tweardy DJ, Scillian JJ, Ellner JJ. Modulation of surface DR antigen expression by recombinant interferon-alpha. Clin Res 32:361A, 1984. e-Pub 1984.
Tweardy DJ, El Kholy A, Ellner JJ. Failure of immunosuppressive mechanisms in patients with hepatosplenic Schistosomiasis mansoni. Clin Res 31:401A, 1983. e-Pub 1983.
Tweardy DJ, Schacter BZ, Ellner JJ. Relationship of surface expression of HLA-DR antigen to suppressor function of human monocytes in tuberculosis. Clin Res 30:380A, 1982. e-Pub 1982.
Tweardy DJ, Baley JE, Schacter BZ, Ellner JJ. Decreased surface expression of HLA-DR antigen on human neonatal cord blood monocytes. Clin Res 30:359A, 1982. e-Pub 1982.
Tweardy DJ, Ellner JJ. Imbalance of T lymphocyte helper to suppressor rations in Schistosoma mansoni infection. American Society of Tropical Medicine and Hygiene Abstract 118, 1982. e-Pub 1982.
Shalaes DM, Lederman MM, Chmielewski RA, Tweardy DJ, Wolinsky E. Elastin fibers in the diagnosis of necrotizing pneumonia. Clin Res 29:396A, 1981. e-Pub 1981.
Tweardy DJ, Jacobs MR, Speck WT. In vitro susceptibility of penicillin resistant pneumococci to third generation cephalosporins and the new penicillins. 21st ICAAC, 1981. e-Pub 1981.
Tweardy DJ, Schacter BZ, Ellner JJ. Altered expression of surface Ia antigen on monocytes in tuberculosis. 21st ICAAC, 1981. e-Pub 1981.
Tweardy DJ, Schacter BZ, Ellner JJ. Bacterial Lipopolysaccharide (LPS) enhances adherent depleted T-cell mitogenesis. Clin Res 29:378A, 1981. e-Pub 1981.

Book Chapters

Bharadawaj U, Kasembeli M, Tweardy DJ. STAT3 inhibitors in cancer: a comprehensive update. In: STAT Inhibitors in Cancer. Springer International, 95-161, 2016.
White SM, Tweardy DJ. Granulocyte colony-stimulating factor. In: The Cytokine Handbook. 4th. Academic Press, 525-546, 2003.
Tweardy DJ, AL Burkhardt AL, J Bolen J, RL Geahlen RL, SJ Corey SJ. G-CSF receptor signaling involves SRC-related and non-SRC related tyrosine kinases with evidence of a three-component complex. In: Molecular Biology of Haematopoiesis. Intercept Ltd, 607-619, 1994.
Morel PA, Townsend K, Gross M, Chiller JM, Tweardy DJ. Monoclonal antibodies to an IL-3-receptor protein. In: Hematopoiesis. Alan R. Liss, Inc, 133-143, 1990.
Rovera G, Tweardy DJ, Santoli D, Kreider B, Valtieri M, Gemperlein I, Mavilio F. Granulopoiesis: In search of growth and differentiation of regulatory genes. In: Phenotypic and Functional Aspects of Hematopoiesis. Raven Press, 17, 1988.
Tweardy DJ, Santoli D, Dietzschold B, Wheelock MJ, Altmann SW, Rovera G. T leukemia-derived suppressor lymphokine (TLSL): Biology and biochemistry. In: : Immune Regulation by Characterized Peptides. UCLA Symposia on Molecular and Cellular Biology. Alan R. Liss, Inc, 485-494, 1986.
Tweardy DJ, Bishop YMM, Donner AP, Klerman GL, Peterson OL, ReichP, Lister-Rosenoer LM, Rosenoer VM, Rosner BA. Lithium maintenance therapy of manic-depressive disorders. In: Current Controversies in Therapeutics. SP Medical Scientific Books, 1980.

Patents

Methods and compositions for treatment of muscle wasting, muscle weakness, and/or cachexia. Patent Number: United States: 11,161,831, Related Patents: PCT/US14/47325, Australia: 2014290368, Canada: based on PCT/US14/37325, Europe: 14826845.1, Hong Kong: 16112393.
STAT3 inhibitors. Patent Number: United States: 8,779,001, Related Patents: PCT/US2009/46143, Europe: 9759351.1, Australia: 2009256253, Canada: 2726987.
Methods and compositions for prevention of allergic reaction. Patent Number: United States Patent Application 14/335,829, Related Patents: PCT/US2014/047324, Australia: 2014290367, Canada: based on PCT/US2014/047324, Europe: 14826325.4, Hong Kong: 16111480.6.
Methods and composition for treatment of fibrosis. Patent Number: United States: 10,112,933, Related Patents: PCT/US14/47319, Australia: 2014290363, Canada: based on PCT/US14/47319, Europe: 14825819.7, Hong Kong: 16112594.7.

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CV information above last modified March 06, 2026

David J. Tweardy, MD

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David J. Tweardy, MD

Present Title & Affiliation

Primary Appointment

Dual/Joint/Adjunct Appointment

Education & Training

Degree-Granting Education

Postgraduate Training

Licenses & Certifications

Experience & Service

Faculty Academic Appointments

Administrative Appointments/Responsibilities

Other Professional Positions

Extramural Institutional Committee Activities

Editorial Activities

Honors & Awards

Professional Memberships

Selected Presentations & Talks

National Presentations

International Presentations

Formal Peers

Grant & Contract Support

Selected Publications

Peer-Reviewed Articles

Invited Articles

Review Articles

Abstracts

Book Chapters

Patents

Patient Reviews

Request an Appointment

Related Links

Internal Medicine Center

Internal Medicine Division

Infectious Diseases, Infection Control & Employee Health Department

Tweardy Laboratory

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Help #EndCancer

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