Dawid Schellingerhout, MBChB, BSc (Hons) (Physiology), CPE, MBA
Department of Neuroradiology, Division of Diagnostic Imaging
About Dr. Schellingerhout
Dr. Schellingerhout joined M D Anderson in 2004 from Massachusetts General Hospital and Harvard Medical School. He regularly publishes in the molecular and neurological imaging literature, and regularly presents data at national and international scientifice meetings.
Dr. Schellingerhout’s research centers on investigating the Nervous System with molecular and novel imaging technologies. His group has developed a set of molecular imaging agents for neurography, the imaging of nerve tissue by means of molecular imaging, and has investigated several preclinical models in preparation to applying this technology to humans.
He also has a patient-centered program investigating the correlations between imaging and biological findings in patients with gliomas, in collaboration with Neurosurgery and Neuropathology, and involving advanced MR imaging directed biopsies correlated to state-of-the-art pathological and biological assessments of harvested patient brain tissues He is also investigating the clinical uses of Dual Energy CT and Phase Sensitive MR in the characterization of cerebral lesions in a human imaging trial.
Research Interests
Molecular Imaging of novel gene and cell based therapies, particularly for Central Nervous System (CNS) conditions Non-invasive mapping of therapeutic gene delivery Assessment of therapeutic gene expression by imaging Pharmacological manipulation of gene therapy vector distribution Focus ultrasound for the disruption of the blood brain barrier Assessment of PET agents for the delineation of brain tumors
Clinical Interests
Developing new imaging technologies and image guided therapies
Education & Training
Degree-Granting Education
| 1994 | University of Pretoria, Faculty of Medicine, Pretoria, ZAF, BSc Hons (cum laude), Physiology |
| 1993 | University of Pretoria, Faculty of Medicine, Pretoria, ZAF, MBChB, Medicine |
Postgraduate Training
| 2013-2023 | Certifying Commission in Medical Management, Certified Physician Executive, American College of Physician Executives, Tampa, FL |
| 2000-2001 | Clinical Fellowship, Neuroradiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA |
| 1999-2000 | Clinical Residency, Neuroradiology Focus Year, Massachusetts General Hospital, Harvard Medical School, Boston, MA |
| 1996-2000 | Clinical Residency, Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA |
| 1995-1996 | General Practice, Cardiology/General Medicine, One Military Hospital, Pretoria |
| 1994-1994 | Clinical Internship, Surgery, Medicine, Anesthesiology, Pediatrics, One Military Hospital, Pretoria |
Board Certifications
| 2002 | American Board of Radiology, Certificate of Additional Qualification in Neuroradiology |
| 2000 | American Board of Radiology, Diagnostic Radiology (valid indefinitely) |
Experience & Service
Academic Appointments
Associate Professor, Department of Cancer Systems Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 2011 - 2018
Assistant Professor, Department of Diagnostic Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 2004 - 2011
Instructor, Department of Diagnostic Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2001 - 2004
Selected Publications
Peer-Reviewed Articles
- Ryu WS, Chung J, Schellingerhout D, Jeong SW, Kim HR, Park JE, Kim BJ, Kim JT, Hong KS, Lee K, Park TH, Park SS, Park JM, Kang K, Cho YJ, Park HK, Lee BC, Yu KH, Oh MS, Lee SJ, Kim JG, Cha JK, Kim DH, Lee J, Han MK, Park MS, Choi KH, Lee J, Bae HJ, Kim DE. Biological Mechanism of Sex Difference in Stroke Manifestation and Outcomes. Neurology 100(24):e2490-e2503, 2023. e-Pub 2023. PMID: 37094993.
- Lin JS, Fuentes DT, Chandler A, Prabhu SS, Weinberg JS, Baladandayuthapani V, Hazle JD, Schellingerhout D. Performance Assessment for Brain MR Imaging Registration Methods. AJNR Am J Neuroradiol 38(5):973-980, 2017. e-Pub 2017. PMID: 28279984.
- Kim DE, Kim JY, Schellingerhout D, Ryu JH, Lee SK, Jeon S, Lee JS, Kim J, Jang HJ, Park JE, Kim EJ, Kwon IC, Ahn CH, Nahrendorf M, Kim K. Quantitative Imaging of Cerebral Thromboemboli In Vivo: The Effects of Tissue-Type Plasminogen Activator. Stroke 48(5):1376-1385, 2017. PMID: 28432262.
- Je KH, Ryu WS, Lee SK, Kim EJ, Kim JY, Jang HJ, Park JE, Nahrendorf M, Schellingerhout D, Kim DE. Green-channel autofluorescence imaging: A novel and sensitive technique to delineate infarcts. J Neurosci Methods 279:22-32, 2017. PMID: 28104485.
- Li CH, Chen FH, Schellingerhout D, Lin YS, Hong JH, Liu HL. Flow versus permeability weighting in estimating the forward volumetric transfer constant (Ktrans) obtained by DCE-MRI with contrast agents of differing molecular sizes. Magn Reson Imaging 36:105-111, 2017. PMID: 27989901.
- Ryu WS, Woo SH, Schellingerhout D, Jang MU, Park KJ, Hong KS, Jeong SW, Na JY, Cho KH, Kim JT, Kim BJ, Han MK, Lee J, Cha JK, Kim DH, Lee SJ, Ko Y, Cho YJ, Lee BC, Yu KH, Oh MS, Park JM, Kang K, Lee KB, Park TH, Lee J, Choi HK, Lee K, Bae HJ, Kim DE. Stroke outcomes are worse with larger leukoaraiosis volumes. Brain 140(Pt 1):158-170, 2017. PMID: 28008000.
- Nute JL, Jacobsen MC, Chandler A, Cody DD, Schellingerhout D. Dual-energy computed tomography for the characterization of intracranial hemorrhage and calcification: a systematic approach in a phantom system. Invest Radiol 52(1):30-41, 2017. PMID: 27379697.
- Shah AR, Muzzafar T, Assi R, Schellingerhout D, Estrov Z, Tamamyan G, Kantarjian H, Daver N. Hemophagocytic lymphohistiocytosis in adults: An under recognized entity. BBA Clin 7:36-40, 2016. PMID: 28070498.
- Kim DE, Kim JY, Lee SK, Ryu JH, Kwon IC, Ahn CH, Kim K, Schellingerhout D. Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli. J Vis Exp 25(115), 2016. PMID: 27768026.
- Ryu WS, Schellingerhout D, Jeong SW, Nahrendorf M, Kim DE. Association between Serum Lipid Profiles and Early Neurological Deterioration in Acute Ischemic Stroke. J Stroke Cerebrovasc Dis 25(8):2024-2030, 2016. PMID: 27256172.
- Bankson JA, Walker CM, Ramirez MS, Stefan W, Fuentes D, Merritt ME, Lee J, Sandulache VC, Chen Y, Phan L, Chou PC, Rao A, Yeung SC, Lee MH, Schellingerhout D, Conrad CA, Malloy C, Sherry AD, Lai SY, Hazle JD. Kinetic Modeling and Constrained Reconstruction of Hyperpolarized [1-13C]-Pyruvate Offers Improved Metabolic Imaging of Tumors. Cancer Res 75(22):4708-4717, 2015. PMID: 26420214.
- Muzzafar S, Rhines LD, Bruner J, Schellingerhout D. Intradural extramedullary Ewing tumor of the lumbar spine. Radiol Case Rep 5(4):421, 2015. PMID: 27307878.
- Kim JY, Ryu JH, Schellingerhout D, Sun IC, Lee SK, Jeon S, Kim J, Kwon IC, Nahrendorf M, Ahn CH, Kim K, Kim DE. Direct Imaging of Cerebral Thromboemboli Using Computed Tomography and Fibrin-targeted Gold Nanoparticles. Theranostics 5(10):1098-1114, 2015. PMID: 26199648.
- Nute JL, Le Roux L, Chandler AG, Baladandayuthapani V, Schellingerhout D, Cody DD. Differentiation of low-attenuation intracranial hemorrhage and calcification using dual-energy computed tomography in a phantom system. Invest Radiol 50(1):9-16, 2015. PMID: 25162534.
- Ryu WS, Woo SH, Schellingerhout D, Chung MK, Kim CK, Jang MU, Park KJ, Hong KS, Jeong SW, Na JY, Cho KH, Kim JT, Kim BJ, Han MK, Lee J, Cha JK, Kim DH, Lee SJ, Ko Y, Cho YJ, Lee BC, Yu KH, Oh MS, Park JM, Kang K, Lee KB, Park TH, Lee J, Choi HK, Lee K, Bae HJ, Kim DE. Grading and interpretation of white matter hyperintensities using statistical maps. Stroke 45(12):3567-3575, 2014. PMID: 25388424.
- Le Roux LG, Bredow S, Grosshans D, Schellingerhout D. Molecular imaging detects impairment in the retrograde axonal transport mechanism after radiation induced spinal cord injury. Mol Imaging Biol 16(4):504-510, 2014. PMID: 24395625.
- Park JY, Lee SK, Kim JY, Je KH, Schellingerhout D, Kim DE. A new micro-computed tomography-based high-resolution blood-brain barrier imaging technique to study ischemic stroke. Stroke 45(8):2480-2484, 2014. PMID: 25013021.
- Ahmed S, Hamilton J, Colen R, Schellingerhout D, Vu T, Rao G, McAleer MF, Mahajan A. Change in postsurgical cavity size within the first 30 days correlates with extent of surrounding edema: consequences for postoperative radiosurgery. J Comput Assist Tomogr 38(3):457-460, 2014. PMID: 24681852.
- Raslan O, Debnam JM, Ketonen L, Kumar AJ, Schellingerhout D, Wang J. Stereoscopic visualization of diffusion tensor imaging data: a comparative survey of visualization techniques. Radiol Res Pract. e-Pub 2013. PMID: 24251037.
- Shin IJ, Shon SM, Schellingerhout D, Park JY, Kim JY, Lee SK, Lee DK, Lee HW, Ahn BC, Kim K, Kwon IC, Kim DE. Characterization of partial ligation-induced carotid atherosclerosis model using dual-modality molecular imaging in ApoE knock-out mice. PLoS One 8(9):e73451, 2013. PMID: 24069197.
- Walker CM, Lee J, Ramirez MS, Schellingerhout D, Millward S, Bankson JA. A catalyzing phantom for reproducible dynamic conversion of hyperpolarized [1-13C]-pyruvate. PLoS One 8(8):e71274, 2013. PMID: 23977006.
- Noh SM, Choi WJ, Kang BT, Jeong SW, Lee DK, Schellingerhout D, Yeo JS, Kim DE. Complementarity between (18) F-FDG PET/CT and Ultrasonography or Angiography in Carotid Plaque Characterization. J Clin Neurol 9(3):176-185, 2013. PMID: 23894241.
- Shon SM, Choi Y, Kim JY, Lee DK, Park JY, Schellingerhout D, Kim DE. Photodynamic therapy using a protease-mediated theranostic agent Reduces cathepsin-B activity in mouse atheromata in vivo. Arterioscler Thromb Vasc Biol 33(6):1360-1365, 2013. PMID: 23539220.
- Kim DE, Kim JY, Sun IC, Schellingerhout D, Lee SK, Ahn CH, Kwon IC, Kim K. Hyperacute direct thrombus imaging using computed tomography and gold nanoparticles. Ann Neurol 73(5):617-625, 2013. PMID: 23495101.
- Shawa H, Busaidy NL, Schellingerhout D, Habra MA. Unilateral renal artery stenosis with renal atrophy in a patient with metastatic papillary thyroid carcinoma treated with sorafenib. BMJ Case Rep. e-Pub 2013. PMID: 23682094.
- Hunter GJ, Schellingerhout D, Vu TH, Perrier ND, Hamberg LM. Accuracy of four-dimensional CT for the localization of abnormal parathyroid glands in patients with primary hyperparathyroidism. Radiology 264(3):789-795, 2012. PMID: 22798226.
- Schellingerhout D, LeRoux LG, Hobbs BP, Bredow S. Impairment of retrograde neuronal transport in oxaliplatin-induced neuropathy demonstrated by molecular imaging. PLoS One 7(9):e45776, 2012. PMID: 23029238.
- Kim JY, Park JH, Jeong SW, Schellingerhout D, Park JE, Lee DK, Choi WJ, Chae SL, Kim DE. High levels of remnant lipoprotein cholesterol is a risk factor for large artery atherosclerotic stroke. J Clin Neurol 7(4):203-209, 2011. PMID: 22259616.
- Kim DE, Kim JY, Nahrendorf M, Lee SK, Ryu JH, Kim K, Kwon IC, Schellingerhout D. Direct thrombus imaging as a means to control the variability of mouse embolic infarct models: the role of optical molecular imaging. Stroke 42(12):3566-3573, 2011. PMID: 22020025.
- Lee DK, Choi Y, Shon SM, Schellingerhout D, Park JE, Kim DE. Atorvastatin and clopidogrel interfere with photosensitization in vitro. Photochem Photobiol Sci 10(10):1587-1592, 2011. PMID: 21748161.
- Shah KB, Guha-Thakurta N, Schellingerhout D, Madewell JE, Kumar AJ, Costelloe CM. Comparison of gadolinium-enhanced fat- saturated T1-weighted FLAIR and fast spin-echo MRI of the spine at 3 T for evaluation of extradural lesions. AJR Am J Roentgenol 197(3):697-703, 2011. PMID: 21862814.
- Vu TH, Guha-Thakurta N, Harrell RK, Ahmed S, Kumar AJ, Johnson VE, Perrier ND, Hamberg LM, Hunter GJ, Schellingerhout D. Imaging characteristics of hyperfunctioning parathyroid adenomas using multiphase multidectector computed tomography: a quantitative and qualitative approach. J Comput Assist Tomogr 35(5):560-567, 2011. PMID: 21926850.
- Wu J, Langford LA, Schellingerhout D, Guha-Thakurta N, Tummala S, Weinberg JS, Puduvalli VK. Progressive multifocal leukoencephalopathy in a patient with glioblastoma. J Neurooncol 103(3):791-796, 2011. PMID: 21120583.
- Shon SM, Park JH, Nahrendorf M, Schellingerhout D, Kim JY, Kang BT, Jeong SW, Kim EJ, Ryu JH, Kim K, Kwon IC, Lee DK, Lee MM, Kim DE. Exercise attenuates matrix metalloproteinase activity in preexisting atherosclerotic plaque. Atherosclerosis 216(1):67-73, 2011. PMID: 21334624.
- Ong SS, Bruner J, Schellingerhout D, Puduvalli VK. Papillary endothelial hyperplasia presenting as recurrent malignant glioma. J Neurooncol 102(3):491-498, 2011. PMID: 20740304.
- Raslan OA, Schellingerhout D, Fuller GN, Ketonen LM.. Rosai-Dorfman disease in neuroradiology: imaging findings in a series of 10 patients. AJR Am J Roentgenol 196(2):W187-193, 2011. PMID: 21257861.
- Kim DE, Park KJ, Schellingerhout D, Jeong SW, Ji MG, Choi WJ, Tak YO, Kwan GH, Koh EA, Noh SM, Jang HY, Kim TY, Jeong JW, Lee JS, Choi HK. A new image-based stroke registry containing quantitative magnetic resonance imaging data. Cerebrovasc Dis 32(6):567-576, 2011. PMID: 22104691.
- Muzzafar S, Ketonen L, Weinberg JS, Schellingerhout D. Imaging and clinical features of an intra-axial brain stem schwannoma. AJNR Am J Neuroradiol 31(3):567-569, 2010. PMID: 19833800.
- Kim DE, Kim JY, Schellingerhout D, Kim EJ, Kim HK, Lee S, Kim K, Kwon IC, Shon SM, Jeong SW, Im SH, Lee DK, Lee MM, Kim GE. Protease imaging of human atheromata captures molecular information of atherosclerosis, complementing anatomic imaging. Arterioscler Thromb Vasc Biol 30(3):449-456, 2010. PMID: 20056915.
- Schellingerhout D, Le Roux LG, Bredow S, Gelovani JG. Fluorescence imaging of fast retrograde axonal transport in living animals. Mol Imaging 8(6):319-329, 2009. PMID: 20003890.
- Kim DE, Kim JY, Schellingerhout D, Shon SM, Jeong SW, Kim EJ, Kim WK. Molecular imaging of cathepsin B proteolytic enzyme activity reflects the inflammatory component of atherosclerotic pathology and can quantitatively demonstrate the antiatherosclerotic therapeutic effects of atorvastatin and glucosamine. Mol Imaging 8(5):291-301, 2009. PMID: 19796606.
- Debnam JM, Schellingerhout D, Kumar AJ, Ketonen L, Shah K, Hamberg LM, Hunter GJ. Multidetector CT-guided lumbar puncture in patients with cancer. Interv Neuroradiol 15(1):61-66, 2009. PMID: 20465930.
- Debnam JM, Schellingerhout D. Focal cement accumulation in lytic metastatic lesions: a new sign in vertebroplasty?. Interv Neuroradiol 14(4):465-470, 2008. PMID: 20557749.
- Mortenson MM, Evans DB, Lee JE, Hunter GJ, Schellingerhout D, Vu T, Edeiken BS, Feng L, Perrier ND. Parathyroid exploration in the reoperative neck: improved preoperative localization with 4D-computed tomography. J Am Coll Surg 206(5):888-896, 2008. PMID: 18471717.