Diana Osorio, MD, MPH
Department of Pediatrics, Division of Pediatrics
Present Title & Affiliation
Primary Appointment
Inpatient Medical Director, Pediatrics - Patient Care, The University of Texas MD Anderson Cancer Center, Houston, Texas
Center Medical Director, Pediatrics - Patient Care, The University of Texas MD Anderson Cancer Center, Houston, Texas
Associate Professor, Pediatrics - Patient Care, The University of Texas MD Anderson Cancer Center, Houston, Texas
Dual/Joint/Adjunct Appointment
Associate Professor, Patient Care, The University of Texas MD Anderson Cancer Center, Houston, Texas
Education & Training
Degree-Granting Education
| 2007 | Universidad Central del Caribe, Puerto Rico, Bayamón, Puerto Rico, US, MD |
Postgraduate Training
| 2013-2014 | Postgraduate Fellow, Neuro-Oncology, New York University Langone Medical Center, New York, New York |
| 2010-2013 | Postgraduate Fellow, Hematology/Oncology, Northwell Health- Cohen Children’s Medical Center, New Hyde Park, New York |
| 2007-2010 | Resident, Pediatrics, Northwell Health- Cohen Children’s Medical Center, New Hyde Park, New York |
Licenses & Certifications
| 2025 | Florida Board of Medicine |
| 2024 | Texas License |
| 2021 | American Board of Pediatrics Hematology Oncology |
| 2017 | American Board of Pediatrics |
Experience & Service
Faculty Academic Appointments
Assistant Professor, Pediatrics, The Ohio State University, Colombus, Ohio, 2014 - 2021
Other Professional Positions
Member, Advisory Board, Day One Advisory Board, 2026 - Present
Member, Society for Neuro-Oncology, MD Anderson Cancer Center, 2020 - Present
Member, Society for Neuro-Oncology, Nationwide Children's, 2013 - Present
Extramural Institutional Committee Activities
Member, Pacific Pediatric Neuro-Oncology Consortium (PNOC) CNS Germ Cell Tumor Working Group, Pediatric Neuro-Oncology Consortium, 2026 - Present
Member, MD Anderson IRB, The University of Texas MD Anderson Cancer Center, 2024 - 2025
Member, Pediatric Clinical Practice Committee, The University of Texas MD Anderson Cancer Center, 2024 - Present
Member, Pediatric Brain Tumor Consortium (PBTC) Ependymoma and Immunotherapy Committee, Nationwide Children's Hospital, 2020 - 2021
Member, Pacific Pediatric Neuro-Oncology Consortium (PNOC) CNS Germ Cell Tumor Working Group, Pediatric Neuro-Oncology Consortium, 2020 - 2021
Member, AACR-PLGAF Pediatric Brain Tumor Research Grants Scientific Review Committee, Nationwide Children's Hospital, 2019 - 2021
Member, Team Hope, Nationwide Children's Hospital, 2016 - 2021
Member, CSRC, Nationwide Children's Hospital, 2016 - 2021
Editorial Activities
Journal Reviewer, Neuro Oncology Pediatrics, 2024 - Present
Topic Editor, Frontiers in Oncology, 2023 - Present
Journal Reviewer, Cancer Reports, 2021 - Present
Journal Reviewer, Oncology research and treatment, 2020 - Present
Journal Reviewer, Journal Pediatric Hematology Oncology, 2020 - Present
Journal Reviewer, Child Nervous System, 2019 - Present
Journal Reviewer, Cancer, 2018 - Present
Journal Reviewer, Pediatric Blood and Cancer, 2017 - 2021
Journal Reviewer, Pediatric Neurology, 2014 - 2018
Honors & Awards
| 2023 - Present | Think Tank: Genetic Predisposition to Primary CNS Cancers |
Selected Presentations & Talks
Local Presentations
- 2024. “Brain Tumors in Neurofibromatosis”. Invited. Texas Neurofibromatosis Foundation Symposium. Houston, Texas, US.
- 2024. Peds Neuro Onc future clinical trials at MDA. Invited. Energy Transfer’s Fundraising Campaign Event. Houston, Texas, US.
Regional Presentations
- 2026. The Impact of International Case Discussions in Pediatric Neuro-Oncology. Invited. Pediatric Neuro-Oncology Symposium: Understanding Pediatric CNS Tumors in LMICs – Improving Care for All. Memphis, Tennessee, US.
- 2025. PNOC033 Study Updates. Pediatric Neuro Oncology Consortium, US.
International Presentations
- 2025. Neuro-Oncologia Pediatrica: Generalidades y Trabajo en Equipo. Invited, CR.
- 2025. Very Long-Term Survival in Patients with Recurrent Central Nervous System (CNS) Germ Cell Tumors (GCT). Poster. International CNS-GCT Conference, US.
- 2025. Choroid Plexus Carcinoma Molecularly-Risk Stratified Treatment Strategy. Invited. VIVA-Asia Rare Tumor Board #17: Infant Brain Tumors – Choroid Plexus, SG.
- 2025. Central Nervous System Tumors Session, Updates on Ependymoma. Invited. 36th SLAOP Annual Meeting and 23rd ACHOP Annual Meeting, US.
- 2024. Management of Germ Cell Tumors in Pediatric Patients. Invited. 42nd National and 11th International Congress of Oncology of the Mexican Society of Oncology, US.
- 2023. Pediatric Neuro-oncology in the New Molecular Era. Invited. Mexican Association of Pediatric OncoHematology (AMOHP), US.
- 2021. Medulloblastoma Treatment Guidelines in Central America. Invited. 23rd annual Association of Pediatric Hematology Oncology in Central America, US.
- 2020. Addressing Global and Loco-Regional Disparities in the Management of Childhood Brain Cancer. Invited. Pediatric Grand Rounds Nationwide Children’s Hospital.
- 2020. Directed Medulloblastoma Treatment Guidelines in Central America. Invited. 22nd annual Association of Pediatric Hematology Oncology in Central America, US.
- 2019. Management of Infant and Childhood Medulloblastoma and the Management of Ependymoma. Invited. 8th Annual Latin American Pediatric Neurosurgery Conference, US.
- 2018. Pediatric Neuro-Oncology Pertinent to Low-to-Middle Income Countries (LMIC). Invited. Co-organizing committee member and 3rd PLANO educational conference at INEN, US.
- 2018. Association of Pediatric Hematology/Oncology of Colombia (ACHOP), Regional conference. Ependymoma and Medulloblastoma. Invited, US.
- 2018. Management of Medulloblastoma, Craniopharyngioma and Central Nervous System Germ Cell Tumors. Leo Messi Foundation Neuro-oncology Course. Invited, US.
- 2017. Experiencia de un grupo de discusión interactivo Latino Americano en tumores del SNC. Latin American Society of Pediatric Oncology (SLAOP). Invited, US.
- 2016. Pediatric Brain Tumors Session, Session Organizer and Moderator: Pediatric Brain Tumor Patient Cases and Discussion of their Management, Association of Pediatric Hematology/Oncology Central America. Invited, US.
- 2015. First International Pediatric Latin American Neurooncology (PLANO) at GRACC Institute; Management of Low Grade Gliomas and Management of ATRT/PNET. Invited, US.
- 2013. Dasatinib in children and adolescents with central nervous system germ cell tumors. Poster. Third International CNS Germ Cell Tumor Symposium, US.
- 2013. Prevalence of elevated erythrocyte adenosine deaminase activity, a marker for Diamond Blackfan Anemia in patients with congenital heart disease. Poster. American Society of Peditaric Hematology Oncology, US.
- 2009. Irradiation-avoiding strategies in the management of young children with newly diagnosed central nervous system embryonal tumors: 18 years of three serial chemotherapy regimens – the “Head Start” Protocols. Invited. Thirty-fifth Annual Meeting of the Korean Cancer Society, US.
Grant & Contract Support
| Date: | 2025 - Present |
| Title: | A Randomized, Open-Label, Phase 2 Study Evaluating Abemaciclib in Combination With Temozolomide Compared to Temozolomide Monotherapy in Children and Young Adults With Newly Diagnosed High-Grade Glioma Following Radiotherapy |
| Funding Source: | Eli Lilly |
| Role: | PI |
| Date: | 2025 - Present |
| Title: | DIPG/DMG Psychosocial Support: Grief-informed interventions to bolster meaning and reduce emotional distress |
| Funding Source: | Children's Brain Tumor Foundation |
| Role: | PI |
| Date: | 2024 - Present |
| Title: | A Phase I clinical trial with a window-of-opportunity component of engineered NK cells containing deleted TGF-βR2 and NR3C1 in recurrent grade 4 astrocytoma (glioblastoma) |
| Funding Source: | SPORE |
| Role: | Co-PI |
| ID: | Protocol Number: 2020-0960 |
| Date: | 2024 - Present |
| Title: | (PNOC-033) Molecular Risk-Adapted Therapy for Newly Diagnosed Choroid Plexus Carcinoma in Children and Young Adults |
| Funding Source: | Philanthropy |
| Role: | PI |
| Date: | 2024 - Present |
| Title: | Phase II Trial Evaluating Chemotherapy Followed by Response- Based Reduced Radiation Therapy for Patients with Central Nervous System Germinomas |
| Funding Source: | COG |
| Role: | Co-PI |
| ID: | ACNS2321 |
| Date: | 2024 - Present |
| Title: | Phase 3 Study of Selumetinib (NSC# 748727, IND# 77782) or Selumetinib in Combination with Vinblastine for non-NF1, non-TSC Patients with Recurrent or Progressive Low-Grade Gliomas (LGGs) Lacking BRAFV600E or IDH1 Mutations |
| Funding Source: | NCI |
| Role: | Co-PI |
| ID: | ACNS1931 |
Selected Publications
Peer-Reviewed Articles
- Osorio, DS, Qaddoumi, I, Moreira, DC. Editorial: Pediatric CNS tumors in low- and middle-income countries: expanding our understanding. Frontiers in Oncology 15, 2025. e-Pub 2025. PMID: 39931086.
- Osorio DS, Patel N, Ji L, Sposto R, Stanek J, Gardner SL, Allen JC, Cornelius A, McCowage GB, Termuhlen A, Dunkel IJ, Comito M, Garvin J, Finlay JL. Pre-irradiation intensive induction and marrow-ablative consolidation chemotherapy in young children with newly diagnosed high-grade brainstem gliomas: report of the "head-start" I and II clinical trials. J Neurooncol 140(3):717-725, 2018. e-Pub 2018. PMID: 30392092.
- Osorio DS, Hu J, Mitchell C, Allen JC, Stanek J, Hagiwara M, Karajannis MA. Effect of lapatinib on meningioma growth in adults with neurofibromatosis type 2. J Neurooncol 139(3):749-755, 2018. e-Pub 2018. PMID: 29948766.
- Osorio DS, Dunkel IJ, Cervone KA, Goyal RK, Steve Lo KM, Finlay JL, Gardner SL. Tandem thiotepa with autologous hematopoietic cell rescue in patients with recurrent, refractory, or poor prognosis solid tumor malignancies. Pediatr Blood Cancer 65(1), 2018. e-Pub 2018. PMID: 28905508.
- Osorio, Finlay JL, Dhall G, Goldman S, Eisenstat D, Brown RJ. Feasibility of dasatinib in children and adolescents with newly-diagnosed or recurrent CNS Germ Cell Tumors. Pediatr Blood Cancer 60(9):E100-102, 2013. e-Pub 2013. PMID: 23754592.
Review Articles
- Osorio DS, Yankelevich M, Lafay-Cousin L, Zaky W. An overview of the diagnosis and management of Choroid Plexus tumors. Adv Cancer Res 167:103-139, 2025. e-Pub 2025. PMID: 41198335.
- Osorio DS, Allen JC. Management of CNS germinoma. CNS Oncol 4(4):273-9, 2015. e-Pub 2015. PMID: 26118663.
Abstracts
- Osorio, DS, Yankelevich, M, Zaky, W, Lafay-Cousin, L, Margol, AS, Toll, SA, Quiroz, L, Fox, JE, Hanson, D, Gardner, S, Prados, M, Mueller, S, Finlay, J. Marrow-ablative consolidation chemotherapy (HDCT) to decrease the development of choroid plexus carcinoma (CPC) specific relapse in high-risk TP53-mutated (germline or somatic) young children with newly diagnosed CPC. Journal of Clinical Oncology 42:2088, 2024. e-Pub 2024.
- Osorio DS. Opening Ceremony-Overview Pediatric Neuro-Oncology Pertinent to Low-to-Middle Income Countries (LMIC). 3rd PLANO educational conference at INEN.
- Osorio DS. Management of Infant and Childhood Medulloblastoma and the Management of Ependymoma. 8th Annual Latin American Pediatric Neurosurgery Conference Neuro-oncology Course.
- Abu Arja MH, Rojas del Río N, Morales La Madrid A, Lassaletta A, Mareno R, Valero M, Perez V, Espinoza F, Fernandez E, Santander J, Tordecilla J, Oyarce V, Kopp K, Bartels U, Qaddoumi I, Finlay J, Cáceres, A, Espinoza X, Osorio DS. Survey on The Resources Available for Pediatric Neuro-oncology in Chile, South America. ASPHO.
- Osorio DS. Directed Medulloblastoma Treatment Guidelines in Central America Workshop. 22nd annual Association of Pediatric Hematology Oncology in Central America (AHOPCA).
- Osorio DS. Global Pediatric Neurooncology in Latin America. 22nd annual Association of Pediatric Hematology Oncology in Central America (AHOPCA).
- Osorio DS. Addressing Global and Loco-Regional Disparities in the Management of Childhood Brain Cancer. Pediatric Grand Rounds Nationwide Children’s Hospital.
- Osorio DS, Pierson CR, Lassaletta A, Morales La Madrid A, Qaddoumi I, Bartels U, Boué DR, Finlay JL. Neuropathology Review of Latin American Childhood Brain Tumors. The Nineteenth International Symposium on Pediatric Neuro-oncology (ISPNO).
- Osorio DS. Medulloblastoma Treatment Guidelines in Central America Review and Protocol Development Workshop. 23rd annual Association of Pediatric Hematology Oncology in Central America (AHOPCA).
- Osorio DS. Manejo de Tumor teratoideo/rabdoide atuipico del Sistema Nervioso Central. 32nd Latin American Society of Pediatric Oncology (SLAOP).
- Osorio DS. Manejo de Ependimoma – Educational session with Latin America. Programa TELEO (Tele-Educacion en Oncologia Pediátrica).
- Osorio DS. Management of Medulloblastoma and Management of Ependymoma. Latin American Society of Neurosurgeons of USA & Canada (SLANC) Latin American Congress of Neurosurgery (CLAN) Pediatric Neurooncology Educational Sessio.
- Osorio DS. Pediatric Neuro-oncology in the New Molecular Era. Agrupacion Mexicana de OncoHematologia Pediátrica (AMOHP).
- Osorio DS, Seiden H, Gruber D, Atsidaftos E, Muir E, Lipton JM, Vlachos A. Prevalence of elevated erythrocyte adenosine deaminase activity, a marker for Diamond Blackfan Anemia in patients with congenital heart disease. American Society of Pediatric Hematology Oncology (ASPHO).
- Osorio DS, Brown RJ, Eisenstat D, Goldman S, Dhall G, Finlay JL. Dasatinib in children and adolescents with central nervous system germ cell tumors. Annual Meeting of the Latin American Society of Pediatric Oncology (SLAOP).
- Osorio DS, Brown RJ, Eisenstat D, Goldman S, Dhall G, Finlay JL. Dasatinib in children and adolescents with central nervous system germ cell tumors. Third International CNS Germ Cell Tumor Symposium.
- Osorio DS, Filatov A, Hagiwara M, Wisoff JH, Golfinos JG, Roland JT, Mitchell C, Allen JC, Karajannis MA. Effects of everolimus on meningioma growth in patients with neurofibromatosis type 2 (NF2). SNO.
- Osorio DS, Filatov A, Hagiwara M, Wisoff JH, Golfinos JG, Roland JT, Mitchell C, Allen JC, Karajannis MA. Effects of everolimus on meningioma growth in patients with neurofibromatosis type 2 (NF2). NF-Conference.
- Osorio DS, Atsidaftos E, Sison CP, Lipton JM, Vlachos A. Deleterious Consequences of Diamond Blackfan Anemia on Reproductive Health and Pregnancy Outcomes: A Report from the Diamond Blackfan Anemia Registry (DBAR). American Society of Hematology (ASH).
- Osorio DS, Margol A, Dhall G, Krieger M, Roach S, Finlay JL. Hearing loss, tinnitus and pineal germinoma: Parinaud’s dorsal midbrain syndrome revisited. Fourth International CNS GCT Symposium.
- Osorio DS, Filatov A, Hagiwara M, Wisoff JH, Golfinos JG, Roland JT, Mitchell C, Allen JC, Karajannis MA. Effects of everolimus on meningioma growth in patients with neurofibromatosis type 2 (NF2). 3rd Biennial SNO Basic and Translational Research Conference.
- Osorio DS. Management of Low Grade Gliomas and Management of ATRT/PNET. First International Pediatric Latin American Neurooncology (PLANO) at GRACC Institute.
- Osorio DS, Hu J, Stanek J, Hagiwara M, Wisoff J, Golfinos JG, Roland R, Mitchell C, Allen JC, Karajannis M. Effects of Lapatinib on Meningiomas in Adults with Neurofibromatosis Type 2 (NF2). 20th Annual Scientific Meeting of the Society for Neuro-oncology (SNO).
- Osorio DS. Pediatric Brain Tumor Patient Cases and Discussion of their Management. Association of Pediatric Hematology/Oncology Central America (AHOPCA).
- Osorio DS, Lassaletta A, Bartels UK, Qaddoumi I, Finlay JF. Potencial para mejorar la calidad de cuidados de ninos con tumors del Sistema Nervioso Central (SNC) en paises de ingresos bajo y medio (PIBM). Latin American Society of Pediatric Oncology (SLAOP).
- Osorio DS, Donson AM, Ahmed N, AbdelBaki MS, Pierson CR, Boué DR, Rusin J, Guiou M, Leonard J, Foreman NK, Finlay JL. Feasibility and tolerability of intravenous and intraventricular traztuzumab in HER2-positive recurrent metastatic ependymoma. Seventeenth International Symposium on Paediatric Neuro-oncology (ISPNO).
- Osorio DS, AbdelBaki MS, Guiou M, Boué DR, Pierson CR, Governale L, Rusin J, Scott S, Capper D, Pfister S, Finlay JL. Outcome of clinical “standard risk” medulloblastoma with CMYC amplification: A case report and assessment of the literature. Seventeenth International Symposium on Paediatric Neuro-oncology (ISPNO).
- Osorio DS. Experiencia de un grupo de discusión interactivo Latino Americano en tumores del SNC. Latin American Society of Pediatric Oncology (SLAOP).
- Osorio DS, Leonard J, Finlay JL. New Approaches to the Management of Recurrent Central Nervous System (CNS) Germinoma in the Current Molecular Era. Fifth International CNS Germ Cell Tumor Symposium.
- Osorio DS. Management of Medulloblastoma, Craniopharyngioma and Central Nervous System Germ Cell Tumors. Leo Messi Foundation Neuro-oncology Course, Hospital Sant Joan de Deu.
- Osorio DS. Treating CNS tumors in low and middle-income countries. SNOLA/SLAOP.
- Osorio DS. Ependymoma and Medulloblastoma. Association of Pediatric Hematology/Oncology of Colombia (ACHOP), Regional conference.
Patient Reviews
CV information above last modified September 08, 2026