Dmitry Nevozhay, M.D., Ph.D.
Department of Imaging Physics, Division of Diagnostic Imaging
Present Title & Affiliation
Primary Appointment
Assistant Professor, Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
My research focuses on the development of quantitative, reproducible platforms for nanoformulation development, biomedical imaging, and the analysis of complex experimental data. My background spans cancer research, bioengineering, nanotechnology, and quantitative analysis, with a convergent trajectory toward building analytical frameworks that improve reproducibility and interpretability in biomedical imaging and cancer research. I develop analysis pipelines with an emphasis on robustness to real experimental conditions and usability for non-computational scientists. I am particularly interested in collaborative, platform-driven projects that support scalable and fundable analytical solutions with potential for broad community adoption and commercialization.
Education & Training
Degree-Granting Education
| 2006 | Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, PL, Experimental Oncology, Ph.D |
| 2002 | Vladivostok State Medical University, Vladivostok, RU, Medicine, M.D |
Postgraduate Training
| 2007-2012 | Postdoctoral Fellowship, Synthetic Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas |
Experience & Service
Faculty Academic Appointments
Instructor, Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2020 - 2022
Research Scientist, Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2017 - 2020
Visiting Scientist, Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2016 - 2017
Principal Scientist, School of Biomedicine, Far Eastern Federal University, Vladivostok, Primorye, 2012 - 2022
Instructor, Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2012 - 2014
Administrative Appointments/Responsibilities
Co-Director of Faculty Development, Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2023 - Present
Intramural Institutional Committee Activities
Member, Residency Recruitment Committee / Imaging Physics, The University of Texas MD Anderson Cancer Center, 2023 - Present
Member, Faculty Recognition Program and Merit Committee / Imaging Physics, The University of Texas MD Anderson Cancer Center, 2022 - Present
Member, Culture of Safety Survey Committee / Imaging Physics, The University of Texas MD Anderson Cancer Center, 2022 - 2024
Grant & Contract Support
| Date: | 2026 - 2028 |
| Title: | Ultrasound-guided cancer immunotherapy with targeted nanodroplets |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | R21CA304638-01A1 |
| Date: | 2025 - 2027 |
| Title: | 129Xe Hyperpolarized Chemical Exchange Saturation Transfer (HyperCEST) MRI for Tracking Immunotherapy Delivery in the Lungs |
| Funding Source: | NIH |
| Role: | Key |
| ID: | F31CA305956 |
| Date: | 2025 - 2027 |
| Title: | High-Throughput Image Processing Software For Reproducible Quantification Of Clonogenic Assays |
| Funding Source: | The University of Texas MD Anderson Cancer Center |
| Role: | PI |
| ID: | RCTS65217 |
| Date: | 2024 - 2025 |
| Title: | Using Perfluorocarbon Nanoparticles 19F MRI to Characterize Space Radiation Induced Acute Pro‐Inflammatory Response and Anti‐Inflammatory Effects of Radiation Mitigating Thrombin Peptide to Extend Healthy Life in Space |
| Funding Source: | Radiological Society of North America (RSNA) |
| Role: | Mentor |
| ID: | RR24‐102 |
| Date: | 2023 - 2026 |
| Title: | Hyperpolarized 129Xe MRI for imaging NK cell therapy of lung metastasis |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| ID: | 5R21CA280799-02 |
| Date: | 2022 - 2027 |
| Title: | In situ cancer cell specific biomineralization to overcome nanoparticle delivery barriers and sensitize pancreatic cancer to radiotherapy |
| Funding Source: | NIH/NCI |
| Role: | Collaborator |
| ID: | 5R01CA274415-03 |
| Date: | 2021 - 2023 |
| Title: | Development of fluorinated dyes for deeper tissue photoacoustic imaging with phase changing nanodroplets |
| Funding Source: | NIH/NIBIB |
| Role: | Collaborator |
| ID: | R21EB030805 |
| Date: | 2020 - 2023 |
| Title: | High sensitivity 19F MRI for clinically translatable imaging of adoptive NK cell brain tumor therapy |
| Funding Source: | CPRIT |
| Role: | Collaborator |
| ID: | RP200223 |
| Date: | 2019 - 2022 |
| Title: | CAR-NK Adoptive Cell Therapy for Osteosarcoma |
| Funding Source: | The University of Texas MD Anderson Cancer Center |
| Role: | Collaborator |
| Date: | 2019 - 2023 |
| Title: | Neoadjuvant treatment response monitoring of breast cancer with molecular photoacoustic imaging |
| Funding Source: | CPRIT |
| Role: | Collaborator |
| ID: | RP190131 |
| Date: | 2019 - 2022 |
| Title: | 3D Imaging of Tumor Mechanobiology Using Nanobomb Optical Coherence Elastography |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 5R21CA231561-02 |
| Date: | 2018 - 2021 |
| Title: | Targeted Phase-change Nanodroplets for Translatable Molecular Ultrasound Imaging of Micrometastases |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 5R21CA234526-02 |
Selected Publications
Peer-Reviewed Articles
- Dyall CR, Nevozhay D, Liu A, Mitcham TM, Lu GJ, Sokolov KV, Bouchard RR. Optimized ultrasound imaging of phase-change nanodroplets. Ultrasonics 161, 2025. e-Pub 2025. PMID: 41456365.
- Nevozhay, D, Rauch, R, Wang, Z, Sokolov, KV. Optimal size and PEG coating of gold nanoparticles for prolonged blood circulation. Nanoscale Advances 7(3):722-727, 2025. e-Pub 2025. PMID: 39811023.
- Mendieta M, Hatami M, Singh M, Saeidi Fard S, Dehshiri M, Schill A, Nevozhay D, Aglyamov S, Ozpolat B, Sokolov KV, Akay YM, Larin KV, Akay M. Non-Invasive Measurement of Elasticity in Glioblastoma Multiforme Validates Decreased TMZ Sensitivity in Astrocyte Co-Culture. IEEE Open J Eng Med Biol 6:287-295, 2025. e-Pub 2025. PMID: 41221443.
- Sehl OC, Yang Y, Anjier AR, Nevozhay D, Cheng D, Guo K, Fellows B, Mohtasebzadeh AR, Mason EE, Sanders T, Kim P, Trease D, Koul D, Goodwill PW, Sokolov K, Wintermark M, Gordon N, Greve JM, Gopalakrishnan V. Preclinical and Clinical-Scale Magnetic Particle Imaging of Natural Killer Cells: in vitro and ex vivo Demonstration of Cellular Sensitivity, Resolution, and Quantification. Mol Imaging Biol 27(1):78-88, 2024. e-Pub 2024. PMID: 39653984.
- Hatami M, Nevozhay D, Singh M, Schill A, Boerner P, Aglyamov S, Sokolov K, Larin KV. Nanobomb optical coherence elastography in multilayered phantoms. Biomed Opt Express 14(11):5670-5681, 2023. e-Pub 2023. PMID: 38021113.
- Kim CS, Nevozhay D, Aburto RR, Pehere A, Pang L, Dillard R, Wang Z, Smith C, Mathieu KB, Zhang M, Hazle JD, Bast RC, Sokolov K. One-Pot, One-Step Synthesis of Drug-Loaded Magnetic Multimicelle Aggregates. Bioconjug Chem 33(5):969-981, 2022. e-Pub 2022. PMID: 35522527.
- Mitcham TM, Nevozhay D, Chen Y, Nguyen LD, Pinton GF, Lai SY, Sokolov KV, Bouchard RR. Effect of Perfluorocarbon Composition on Activation of Phase-Changing Ultrasound Contrast Agents. Med Phys 49(4):2212-2219, 2022. e-Pub 2022. PMID: 35195908.
- Doshi A, Bandey I, Nevozhay D, Varadarajan N, Cirino PC. Design and characterization of a salicylic acid-inducible gene expression system for Jurkat cells. J Biotechnol 346:11-14, 2022. e-Pub 2022. PMID: 35051448.
- Kupczyk P, Simiczyjew A, Marczuk J, Dratkiewicz E, Beberok A, Rok J, Pieniazek M, Biecek P, Nevozhay D, Slowikowski B, Chodaczek G, Wrzesniok D, Nowak D, Donizy P. PARP1 as a Marker of an Aggressive Clinical Phenotype in Cutaneous Melanoma-A Clinical and an In Vitro Study. Cells 10(2):1-21, 2021. e-Pub 2021. PMID: 33572647.
- Boerner P, Nevozhay D, Hatamimoslehabadi M, Chawla HS, Zvietcovich F, Aglyamov S, Larin KV, Sokolov KV. Repetitive optical coherence elastography measurements with blinking nanobombs. Biomed Opt Express 11(11):6659-6673, 2020. e-Pub 2020. PMID: 33282515.
- Nevozhay D, Weiger M, Friedl P, Sokolov KV. Spatiotemporally controlled nano-sized third harmonic generation agents. Biomed Opt Express 10(7):3301-3316, 2019. e-Pub 2019. PMID: 31360600.
- Liu CH, Nevozhay D, Zhang H, Das S, Schill A, Singh M, Aglyamov S, Sokolov KV, Larin KV. Longitudinal elastic wave imaging using nanobomb optical coherence elastography. Opt Lett 44(12):3162-3165, 2019. e-Pub 2019. PMID: 31199406.
- Farquhar KS, Charlebois DA, Szenk M, Cohen J, Nevozhay D, Balázsi G. Role of network-mediated stochasticity in mammalian drug resistance. Nat Commun 10(1):2766, 2019. e-Pub 2019. PMID: 31235692.
- Liu CH, Nevozhay D, Schill A, Singh M, Das S, Nair A, Han Z, Aglyamov S, Larin KV, Sokolov KV. Nanobomb optical coherence elastography. Opt Lett 43(9):2006-2009, 2018. e-Pub 2018. PMID: 29714732.
- Kupczyk P, Reich A, Gajda M, Holysz M, Wysokinska E, Paprocka M, Nevozhay D, Chodaczek G, Jagodzinski PP, Ziólkowski P, Szepietowski JC. UCHL1/PGP 9.5 Dynamic in Neuro-Immune-Cutaneous Milieu: Focusing on Axonal Nerve Terminals and Epidermal Keratinocytes in Psoriatic Itch. Biomed Res Int 2018:7489316, 2018. e-Pub 2018. PMID: 30148172.
- Kupczyk P, Reich A, Holysz M, Gajda M, Wysokinska E, Kobuszewska A, Nevozhay D, Nowakowska B, Strzadala L, Jagodzinski PP, Szepietowski JC. Opioid Receptors in Psoriatic Skin: Relationship with Itch. Acta Derm Venereol 97(5):564-570, 2017. e-Pub 2017. PMID: 27958613.
- Bodi Z, Farkas Z, Nevozhay D, Kalapis D, Lazar V, Csorgo B, Nyerges A, Szamecz B, Fekete G, Papp B, Araujo H, Oliveira JL, Moura G, Santos MAS, Szekely T Jr, Balazsi G, Pal C. Phenotypic heterogeneity promotes adaptive evolution. PLoS Biol 15(5):e2000644, 2017. e-Pub 2017. PMID: 28486496.
- Diao J, Charlebois DA, Nevozhay D, Bódi Z, Pál C, Balázsi G. Efflux Pump Control Alters Synthetic Gene Circuit Function. ACS Synth Biol 5(7):619-31, 2016. e-Pub 2016. PMID: 27111147.
- González C, Ray JC, Manhart M, Adams RM, Nevozhay D, Morozov AV, Balázsi G. Stress-response balance drives the evolution of a network module and its host genome. Mol Syst Biol 11(8):827, 2015. e-Pub 2015. PMID: 26324468.
- Chen L, Noorbakhsh J, Adams RM, Samaniego-Evans J, Agollah G, Nevozhay D, Kuzdzal-Fick J, Mehta P, Balazsi G. Two-dimensionality of yeast colony expansion accompanied by pattern formation. PLoS Comput Biol:e1003979, 2014. e-Pub 2014. PMID: 25504059.
- Nevozhay, D. Cheburator software for automatically calculating drug inhibitory concentrations from in vitro screening assays. PLoS One 9(9):e106186, 2014. e-Pub 2014. PMID: 25184280.
- Goszczynski T, Nevozhay D, Wietrzyk J, Omar MS, Boratynski J. The antileukemic activity of modified fibrinogen-methotrexate conjugate. Biochim Biophys Acta 1830(3):2526-2530, 2013. e-Pub 2013. PMID: 23168301.
- Nevozhay D, Zal T, Balázsi G. Transferring a synthetic gene circuit from yeast to mammalian cells. Nat Commun 4:1451, 2013. e-Pub 2013. PMID: 23385595.
- Nevozhay D, Adams RM, Van Itallie E, Bennett MR, Balázsi G. Mapping the environmental fitness landscape of a synthetic gene circuit. PLoS Comput Biol 8(4):e1002480, 2012. e-Pub 2012. PMID: 22511863.
- Jagiello M, Kanska U, Nevozhay D, Boratynski J. Synthesis and biological activity of raltitrexed-carrier conjugates. Acta Biochim Pol 57(1):83-7, 2010. e-Pub 2010. PMID: 20349025.
- Szczaurska-Nowak K, Dabrowska K, Celka M, Kurzepa A, Nevozhay D, Wietrzyk J, Switala-Jelen K, Syper D, Pozniak G, Opolski A, Gorski A, Radzikowski C. Antitumor effect of combined treatment of mice with cytostatic agents and bacteriophage T4. Anticancer Res 29(6):2361-70, 2009. e-Pub 2009. PMID: 19528503.
- Nevozhay D, Adams RM, Murphy KF, Josic K, Balazsi G. Negative autoregulation linearizes the dose-response and suppresses the heterogeneity of gene expression. Proc Natl Acad Sci U S A 106(13):5123-8, 2009. e-Pub 2009. PMID: 19279212.
- Kanska U, Budzynska R, Nevozhay D, Boratynski J. Preparation of mannan-protein conjugates using high-temperature glycation. Biotechnol Appl Biochem 49(Pt 1):57-64, 2008. e-Pub 2008. PMID: 17630955.
- Wietrzyk J, Nevozhay D, Milczarek M, Filip B, Kutner A. Toxicity and antitumor activity of the vitamin D analogs PRI-1906 and PRI-1907 in combined treatment with cyclophosphamide in a mouse mammary cancer model. Cancer Chemother Pharmacol 62(5):787-97, 2008. e-Pub 2008. PMID: 18188568.
- Budzynska R, Nevozhay D, Kanska U, Jagiello M, Opolski A, Wietrzyk J, Boratynski J. Antitumor activity of mannan-methotrexate conjugate in vitro and in vivo. Oncol Res 16(9):415-21, 2007. e-Pub 2007. PMID: 18074676.
- Wietrzyk J, Nevozhay D, Filip B, Milczarek M, Kutner A. The antitumor effect of lowered doses of cytostatics combined with new analogs of vitamin D in mice. Anticancer Res 27(5A):3387-98, 2007. e-Pub 2007. PMID: 17970085.
- Nevozhay D, Budzynska R, Jagiello M, Kanska U, Omar MS, Opolski A, Wietrzyk J, Boratynski J. The effect of the substitution level of some dextran-methotrexate conjugates on their antitumor activity in experimental cancer models. Anticancer Res 26(3A):2179-86, 2006. e-Pub 2006. PMID: 16827162.
- Nevozhay D, Budzynska R, Kanska U, Jagiello M, Omar MS, Boratynski J, Opolski A. Antitumor properties and toxicity of dextran-methotrexate conjugates are dependent on the molecular weight of the carrier. Anticancer Res 26(2A):1135-43, 2006. e-Pub 2006. PMID: 16619515.
- Siwy M, Sek D, Kaczmarczyk B, Jaroszewicz I, Nasulewicz A, Pelczynska M, Nevozhay D, Opolski A. Synthesis and in vitro antileukemic activity of some new 1,3-(oxytetraethylenoxy)cyclotriphosphazene derivatives. J Med Chem 49(2):806-10, 2006. e-Pub 2006. PMID: 16420065.
- Dabrowska K, Opolski A, Wietrzyk J, Nevozhay D, Szczaurska K, Switala-Jelen K, Boratynski J, Gorski A. Activity of bacteriophages in murine tumor models depends on the route of phage administration. Oncol Res 15(4):183-7, 2005. e-Pub 2005. PMID: 17822278.
- Pelczynska M, Wietrzyk J, Jaroszewicz I, Nevozhay D, Switalska M, Kutner A, Zabel M, Opolski A. Correlation between VDR expression and antiproliferative activity of vitamin D3 compounds in combination with cytostatics. Anticancer Res 25(3B):2235-40, 2005. e-Pub 2005. PMID: 16158969.
- Kanska U, Omar MS, Budzynska R, Nevozhay D, Jagiello M, Opolski A, Boratynski J. Antileukemic activity of glycated fibrinogen-methotrexate conjugates. Anticancer Res 25(3B):2229-34, 2005. e-Pub 2005. PMID: 16158968.
- Nawrocka W, Szutuba B, Liszkiewicz H, Kowalska MW, Wietrzyk J, Nevozhay D, Opolski A. Synthesis and antiproliferative activity in vitro of new 2-aminobenzimidazole. Polish J Chem 79:709-716, 2005. e-Pub 2005.
Invited Articles
- Schuemann J, Bagley AF, Berbeco R, Bromma K, Butterworth KT, Byrne HL, Chithrani BD, Cho SH, Cook JR, Favaudon V, Gholami YH, Gargioni E, Hainfeld JF, Hespeels F, Heuskin AC, Ibeh UM, Kuncic Z, Kunjachan S, Lacombe S, Lucas S, Lux F, McMahon S, Nevozhay D, Ngwa W, Payne JD, Penninckx S, Porcel E, Prise KM, Rabus H, Ridwan SM, Rudek B, Sanche L, Singh B, Smilowitz HM, Sokolov KV, Sridhar S, Stanishevskiy Y, Sung W, Tillement O, Virani N, Yantasee W, Krishnan S. Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions. Phys Med Biol 65(21):21RM02, 2020. e-Pub 2020. PMID: 32380492.
Review Articles
- Nevozhay D, Kanska U, Budzynska R, Boratynski J. [Current status of research on conjugates and related drug delivery systems in the treatment of cancer and other diseases]. Postepy Hig Med Dosw (Online) 61:350-60, 2007. e-Pub 2007. PMID: 17554238.
- Nevozhay D, Opolski A. Key factors in experimental mouse hematopoietic stem cell transplantation. Arch Immunol Ther Exp (Warsz) 54(4):253-69, 2006. e-Pub 2006. PMID: 16868724.
Book Chapters
- Nevozhay, D, Bouchard, RR, Sokolov, KV. Photoacoustic Imaging with Plasmonic Nanoparticles. In: World Scientific Reference on Plasmonic Nanomaterials: Principles, Design and Bio-applications, 325-370, 2022.
- Charlebois DA, Diao J, Nevozhay D, Balazsi G. Negative Regulation Gene Circuits for Efflux Pump Control. In: Methods Mol Biol, 25-43, 2018.
- Nevozhay D, Adams RM, Balazsi G. Linearizer gene circuits with negative feedback regulation. In: Yeast Genetic Networks: Methods and Protocols, 81-100, 2011.
- Siwy M, Sek D, Kaczmarczyk B, Jaroszewicz I, Nasulewicz A, Pelczynska M, Nevozhay D, Opolski A. [Macrocyclic cyclophosphazene derivatives with cytostatic activity]. In: [Modification of Polymers], 623-626, 2005.
Patient Reviews
CV information above last modified August 07, 2026