Dmitry Nevozhay, M.D., Ph.D.
Department of Imaging Physics, Division of Diagnostic Imaging
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2006 | Institute of Immunology and Experimental Therapy, Warsaw, POL, PHD, Experimental Oncology |
| 2002 | Vladivostok State Medical University, Vladivostok, RUS, MD, Medicine |
Postgraduate Training
| 2007-2012 | Postdoctoral Fellowship, Synthetic Biology, The University of Texas MD Anderson Cancer Center, Houston, TX |
| 2007-2007 | Postdoctoral Fellowship, Experimental Oncology, Institute of Immunology and Experimental Therapy, Wroclaw |
Experience & Service
Academic Appointments
Instructor, Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 2020 - 2022
Research Scientist, Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 2017 - 2020
Principal Scientist, Far Eastern Federal University, School of Biomedicine, Vladivostok, 2014 - 2022
Instructor, Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2012 - 2014
Docent, Far Eastern Federal University, Vladivostok, 2012 - 2014
Other Appointments/Responsibilities
Visiting Scientist, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 2016 - 2017
Honors & Awards
| 2011 | Young Researcher Travel Award, Synthetic Biology 5.0 Conference, Stanford University, USA |
| 2010 | Best Poster Award, From Networks to Pattern Formation Symposium, Rice University |
| 2009 | AMGEN Award in Basic Science Research, UT MDACC |
| 2008 | Second Prize Poster Award, Systems Biology of Cancer Conference, UT MDACC |
| 2007 | Postdoctoral Fellowship, Jozef Mianowski Fund and Foundation for Polish Science. Warsaw Poland |
| 2006 | Ph.D. with Honors, Maria Sklodowska-Curie Memorial Cancer Center, Warsaw, Poland |
| 2005 | The Best Scientific Work Award, The Vth Conference of Young Scientists / The VIth Russian Oncological Congress |
| 2005 | Travel grants, NDDO Research Foundation, Amsterdam, The Netherlands |
| 2005 | Travel grant, European School of Hematology, Paris, France |
| 2002 | Ph.D. Scholarship, Polish Ministry of Science and Education, Poland |
Selected Publications
Peer-Reviewed Articles
- Kim CS, Nevozhay D, Aburto RR, Pehere A, Pang L, Dillard R, Wang Z, Smith C, Mathieu KB, Zhang M, Hazle JD, Bast RC, Sokolov K. One-Pot, One-Step Synthesis of Drug-Loaded Magnetic Multimicelle Aggregates. Bioconjug Chem 33(5):969-981, 2022. e-Pub 2022. PMID: 35522527.
- Mitcham TM, Nevozhay D, Chen Y, Nguyen LD, Pinton GF, Lai SY, Sokolov KV, Bouchard RR. Effect of Perfluorocarbon Composition on Activation of Phase-Changing Ultrasound Contrast Agents. Med Phys 49(4):2212-2219, 2022. e-Pub 2022. PMID: 35195908.
- Doshi A, Bandey I, Nevozhay D, Varadarajan N, Cirino PC. Design and characterization of a salicylic acid-inducible gene expression system for Jurkat cells. J Biotechnol 346:11-14, 2022. e-Pub 2022. PMID: 35051448.
- Kupczyk P, Simiczyjew A, Marczuk J, Dratkiewicz E, Beberok A, Rok J, Pieniazek M, Biecek P, Nevozhay D, Slowikowski B, Chodaczek G, Wrzesniok D, Nowak D, Donizy P. PARP1 as a Marker of an Aggressive Clinical Phenotype in Cutaneous Melanoma-A Clinical and an In Vitro Study. Cells 10(2), 2021. e-Pub 2021. PMID: 33572647.
- Boerner P, Nevozhay D, Hatamimoslehabadi M, Chawla HS, Zvietcovich F, Aglyamov S, Larin KV, Sokolov KV. Repetitive optical coherence elastography measurements with blinking nanobombs. Biomed Opt Express 11(11):6659-6673, 2020. e-Pub 2020. PMID: 33282515.
- Nevozhay D, Weiger M, Friedl P, Sokolov KV. Spatiotemporally controlled nano-sized third harmonic generation agents. Biomed Opt Express 10(7):3301-3316, 2019. e-Pub 2019. PMID: 31360600.
- Liu CH, Nevozhay D, Zhang H, Das S, Schill A, Singh M, Aglyamov S, Sokolov KV, Larin KV. Longitudinal elastic wave imaging using nanobomb optical coherence elastography. Opt Lett 44(12):3162-3165, 2019. PMID: 31199406.
- Farquhar KS, Charlebois DA, Szenk M, Cohen J, Nevozhay D, Balázsi G. Role of network-mediated stochasticity in mammalian drug resistance. Nat Commun 10(1):2766, 2019. e-Pub 2019. PMID: 31235692.
- Liu CH, Nevozhay D, Schill A, Singh M, Das S, Nair A, Han Z, Aglyamov S, Larin KV, Sokolov KV. Nanobomb optical coherence elastography. Opt Lett 43(9):2006-2009, 2018. PMID: 29714732.
- Bódi Z, Farkas Z, Nevozhay D, Kalapis D, Lázár V, Csörgo B, Nyerges Á, Szamecz B, Fekete G, Papp B, Araújo H, Oliveira JL, Moura G, Santos MAS, Székely T, Balázsi G, Pál C. Phenotypic heterogeneity promotes adaptive evolution. PLoS Biol:e2000644, 2017. e-Pub 2017. PMID: 28486496.
- Diao J, Charlebois DA, Nevozhay D, Bódi Z, Pál C, Balázsi G. Efflux Pump Control Alters Synthetic Gene Circuit Function. ACS Synth Biol 5(7):619-31, 2016. e-Pub 2016. PMID: 27111147.
- González C, Ray JC, Manhart M, Adams RM, Nevozhay D, Morozov AV, Balázsi G. Stress-response balance drives the evolution of a network module and its host genome. Mol Syst Biol 11(8):827, 2015. e-Pub 2015. PMID: 26324468.
- Nevozhay, D.. Cheburator software for automatically calculating drug inhibitory concentrations from in vitro screening assays. PLoS One 9(9):e106186, 2014. PMID: 25184280.
- Goszczynski T, Nevozhay D, Wietrzyk J, Omar MS, Boratynski J. The antileukemic activity of modified fibrinogen-methotrexate conjugate. Biochim Biophys Acta 1830(3):2526-2530, 2013. e-Pub 2012. PMID: 23168301.
- Nevozhay D, Zal T, Balázsi G. Transferring a synthetic gene circuit from yeast to mammalian cells. Nat Commun 4:1451, 2013. PMID: 23385595.
- Nevozhay D, Adams RM, Van Itallie E, Bennett MR, Balázsi G. Mapping the environmental fitness landscape of a synthetic gene circuit. PLoS Comput Biol 8(4):e1002480, 2012. e-Pub 2012. PMID: 22511863.
- Jagiello M, Kanska U, Nevozhay D, Boratynski J. Synthesis and biological activity of raltitrexed-carrier conjugates. Acta Biochim Pol 57(1):83-7, 2010. e-Pub 2010. PMID: 20349025.
- Nevozhay D, Adams RM, Murphy KF, Josic K, Balazsi G. Negative autoregulation linearizes the dose-response and suppresses the heterogeneity of gene expression. Proc Natl Acad Sci U S A 106(13):5123-8, 2009. e-Pub 2009. PMID: 19279212.
- Budzynska R, Nevozhay D, Kanska U, Jagiello M, Opolski A, Wietrzyk J, Boratynski J. Antitumor activity of mannan-methotrexate conjugate in vitro and in vivo. Oncol Res 16(9):415-21, 2007. PMID: 18074676.
- Nevozhay D, Budzynska R, Jagiello M, Kanska U, Omar MS, Opolski A, Wietrzyk J, Boratynski J. The effect of the substitution level of some dextran-methotrexate conjugates on their antitumor activity in experimental cancer models. Anticancer Res 26(3A):2179-86, 2006. PMID: 16827162.
- Nevozhay D, Budzynska R, Kanska U, Jagiello M, Omar MS, Boratynski J, Opolski A. Antitumor properties and toxicity of dextran-methotrexate conjugates are dependent on the molecular weight of the carrier. Anticancer Res 26(2A):1135-43, 2006. PMID: 16619515.
- Siwy M, Sek D, Kaczmarczyk B, Jaroszewicz I, Nasulewicz A, Pelczynska M, Nevozhay D, Opolski A. Synthesis and in vitro antileukemic activity of some new 1,3-(oxytetraethylenoxy)cyclotriphosphazene derivatives. J Med Chem 49(2):806-10, 2006. PMID: 16420065.
- Kanska U, Omar MS, Budzynska R, Nevozhay D, Jagiello M, Opolski A, Boratynski J. Antileukemic activity of glycated fibrinogen-methotrexate conjugates. Anticancer Res 25(3B):2229-34, 2005. PMID: 16158968.
Invited Articles
- Schuemann J, Bagley AF, Berbeco R, Bromma K, Butterworth KT, Byrne HL, Chithrani BD, Cho SH, Cook JR, Favaudon V, Gholami YH, Gargioni E, Hainfeld JF, Hespeels F, Heuskin AC, Ibeh UM, Kuncic Z, Kunjachan S, Lacombe S, Lucas S, Lux F, McMahon S, Nevozhay D, Ngwa W, Payne JD, Penninckx S, Porcel E, Prise KM, Rabus H, Ridwan SM, Rudek B, Sanche L, Singh B, Smilowitz HM, Sokolov KV, Sridhar S, Stanishevskiy Y, Sung W, Tillement O, Virani N, Yantasee W, Krishnan S. Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions. Phys Med Biol 65(21):21RM02, 2020. e-Pub 2020. PMID: 32380492.
- Nevozhay D, Kanska U, Budzynska R, Boratynski J. Current status of research on conjugates and related drug delivery systems in the treatment of cancer and other diseases. Postepy Hig Med Dosw (Online) 61:350-60, 2007. e-Pub 2007. PMID: 17554238.
- Nevozhay D, Budzynska R, Kanska U, Jagiello M, Boratynski J. Modern ideas about the mechanism of antineoplastic action of methotrexate and resistance to it. Pacific Medical Journal 4:12-16, 2006.
Book Chapters
- Nevozhay D, Bouchard R, Sokolov KV. Photoacoustic Imaging with Plasmonic Nanoparticles. In: World Scientific Reference on Plasmonic Nanomaterials: Principles, Design and Bio-applications, 2022.
- Charlebois D.A., Diao J., Nevozhay D., Balazsi G.. Negative regulation gene circuits for efflux pump control. In: Synthetic Biology: Methods and Protocols. 1. Humana Press, 25-43, 2018.
- Nevozhay D, Adams RM, Balazsi G. Linearizer gene circuits with negative feedback regulation. In: Yeast Genetic Networks: Methods and Protocols, 81-100, 2011.
- Siwy M, Sek D, Kaczmarczyk B, Jaroszewicz I, Nasulewicz A, Pelczynska M, Nevozhay D, Opolski A. [Macrocyclic cyclophosphazene derivatives with cytostatic activity]. In: [Modification of Polymers], 623-626, 2005.