Meet Edwin Ostrin, M.D., Ph.D.
Edwin J. Ostrin, M.D., Ph.D.
Department of General Internal Medicine, Division of Internal Medicine
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of General Internal Medicine, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Assistant Professor, Department of Pulmonary Medicine, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Education & Training
Degree-Granting Education
| 2006 | Baylor College of Medicine, Houston, TX, USA, MD, Medicine |
| 2005 | Baylor College of Medicine, Houston, TX, USA, PHD, Molecular and Human Genetics |
| 1997 | University of Texas at Austin, Austin, TX, USA, BS, Molecular Biology |
Postgraduate Training
| 2009-2013 | Clinical Fellowship, Pulmonary/Critical Care, University of California, San Francisco, San Francisco, CA |
| 2006-2009 | Clinical Residency, Internal Medicine, Johns Hopkins Hospital, Baltimore, MD |
Board Certifications
| 2021 | American Board of Internal Medicine |
| 2012 | American Board of Internal Medicine |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Ostrin EJ, Little DR, Gerner-Mauro KN, Sumner EA, Ríos-Corzo R, Ambrosio E, Holt SE, Forcioli-Conti N, Akiyama H, Hanash SM, Kimura S, Huang SXL, Chen J. Developmental stage dependent regulation of lung epithelial progenitors by beta-Catenin. Development 145(5), 2018. e-Pub 2018. PMID: 29440304.
- Vykoukal J, Sun N, Aguilar-Bonavides C, Katayama H, Tanaka I, Fahrmann JF, Capello M, Fujimoto J, Aguilar M, Wistuba II, Taguchi A, Ostrin EJ, Hanash SM. Plasma-derived extracellular vesicle proteins as a source of biomarkers for lung adenocarcinoma. Oncotarget 8(56):95466-95480, 2017. e-Pub 2017. PMID: 29221141.
- Unver N, Delgado O, Zeleke K, Cumpian A, Tang X, Caetano MS, Wang H, Katayama H, Yu H, Szabo E, Wistuba II, Moghaddam SJ, Hanash SM, Ostrin EJ. Reduced IL-6 levels and tumor-associated phospho-STAT3 are associated with reduced tumor development in a mouse model of lung cancer chemoprevention with myo-inositol. Int J Cancer. e-Pub 2017. PMID: 29134640.
- Tripathi SC, Fahrmann JF, Celiktas M, Aguilar M, Marini KD, Jolly MK, Katayama H, Wang H, Murage EN, Dennison JB, Watkins DN, Levine H, Ostrin EJ, Taguchi A, Hanash SM. MCAM Mediates Chemoresistance in Small-Cell Lung Cancer via the PI3K/AKT/SOX2 Signaling Pathway. Cancer Res 77(16):4414-4425, 2017. e-Pub 2017. PMID: 28646020.
- Çeliktas M, Tanaka I, Tripathi SC, Fahrmann JF, Aguilar-Bonavides C, Villalobos P, Delgado O, Dhillon D, Dennison JB, Ostrin EJ, Wang H, Behrens C, Do KA, Gazdar AF, Hanash SM, Taguchi A. Role of CPS1 in Cell Growth, Metabolism and Prognosis in LKB1-Inactivated Lung Adenocarcinoma. J Natl Cancer Inst 109(3):1-9, 2017. PMID: 28376202.
- Tsou P, Katayama H, Ostrin EJ, Hanash SM. The Emerging Role of B Cells in Tumor Immunity. Cancer Res 76(19):5597-5601, 2016. e-Pub 2016. PMID: 27634765.
- Caetano MS, Zhang H, Cumpian AM, Gong L, Unver N, Ostrin EJ, Daliri S, Chang SH, Ochoa CE, Hanash S, Behrens C, Wistuba II, Sternberg C, Kadara H, Ferreira CG, Watowich SS, Moghaddam SJ. L6 blockade reprograms the lung tumor microenvironment to limit the development and progression of K-ras-mutant lung cancer. Cancer Res 76(11):3189-99, 2016. e-Pub 2016. PMID: 27197187.
- Tripathi SC, Peters HL, Taguchi A, Katayama H, Wang H, Momin A, Jolly MK, Celiktas M, Rodriguez-Canales J, Liu H, Behrens C, Wistuba II, Ben-Jacob E, Levine H, Molldrem JJ, Hanash SM, Ostrin EJ. Immunoproteasome deficiency is a feature of non-small cell lung cancer with a mesenchymal phenotype and is associated with a poor outcome. Proc Natl Acad Sci U S A 113(11):E1555-64, 2016. e-Pub 2016. PMID: 26929325.
- Yang J, Hernandez BJ, Martinez Alanis D, Narvaez del Pilar O, Vila-Ellis L, Akiyama H, Evans SE, Ostrin EJ, Chen J. The development and plasticity of alveolar type 1 cells. Development 143(1):54-65, 2016. e-Pub 2015. PMID: 26586225.
- Hanash S, Taguchi A, Wang H, Ostrin EJ. Deciphering the complexity of the cancer proteome for diagnostic applications. Expert Rev Mol Diagn 16(4):1-7, 2016. e-Pub 2016. PMID: 26694525.
- Solberg OD, Ostrin EJ, Love MI, Peng JC, Bhakta NR, Hou L, Nguyen C, Solon M, Nguyen C, Barczak AJ, Zlock LT, Blagev DP, Finkbeiner WE, Ansel KM, Arron JR, Erle DJ, Woodruff PG. Airway epithelial miRNA expression is altered in asthma. Am J Respir Crit Care Med 186(10):965-74, 2012. e-Pub 2012. PMID: 22955319.
- Zeidner JF, Ostrin EJ, Sydnor E, Fine D, Sperati CJ. The tissue's the issue. Am J Med 123(5):420-2, 2010. PMID: 20399317.
- Ostrin EJ, Li Y, Hoffman K, Liu J, Wang K, Zhang L, Mardon G, Chen R. Genome-wide identification of direct targets of the Drosophila retinal determination protein Eyeless. Genome Res 16(4):466-76, 2006. e-Pub 2006. PMID: 16533912.
- Pappu KS, Ostrin EJ, Middlebrooks BW, Sili BT, Chen R, Atkins MR, Gibbs R, Mardon G. Dual regulation and redundant function of two eye-specific enhancers of the Drosophila retinal determination gene dachshund. Development 132(12):2895-905, 2005. PMID: 15930118.
- Tavsanli BC, Ostrin EJ, Burgess HK, Middlebrooks BW, Pham TA, Mardon G. Structure-function analysis of the Drosophila retinal determination protein Dachshund. Dev Biol 272(1):231-47, 2004. PMID: 15242803.
- Rayapureddi JP, Kattamuri C, Steinmetz BD, Frankfort BJ, Ostrin EJ, Mardon G, Hegde RS. Eyes absent represents a class of protein tyrosine phosphatases. Nature 426(6964):295-8, 2003. PMID: 14628052.
- Lloyd TE, Verstreken P, Ostrin EJ, Phillippi A, Lichtarge O, Bellen HJ. A genome-wide search for synaptic vesicle cycle proteins in Drosophila. Neuron 26(1):45-50, 2000. PMID: 10798391.
- Geissler HJ, Davis KL, Laine GA, Ostrin EJ, Mehlhorn U, Hekmat K, Warters RD, Allen SJ. Myocardial protection with high-dose beta-blockade in acute myocardial ischemia. Eur J Cardiothorac Surg 17(1):63-70, 2000. PMID: 10735414.
Grant & Contract Support
| Title: | |
| Funding Source: | Lung Cancer Research Foundation |
| Role: | Principal Investigator |