Fabien Delerue, M.Sc., Ph.D.
Department of Genetics, Division of Discovery Science
Present Title & Affiliation
Primary Appointment
Associate Professor, Department of Genetics, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, TX
Honorary Senior Research Fellow, Department of Biomedical Sciences, Macquarie University, Sydney, New South Wales
Dual/Joint/Adjunct Appointment
Associate Professor, Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX
Research Interests
Genetically modified (GM) animals are the most powerful tools to understand the mechanisms underlying physiological processes and their pathological counterparts. They are also invaluable tools to search for disease modifiers and to develop and test novel treatment strategies.
Meanwhile, cutting-edge technologies such as engineered endonucleases designed to target and eventually cleave specific DNA sequences have emerged as ultimate methods to accelerate the process of genome editing and apply it to virtually any living species. Likewise, assisted reproductive techniques and gene transfer techniques have also extensively been refined, facilitating the generation of genetically modified animals for biomedical purposes.
Our transgenic core capitalizes on its own technology development program to generate customized rodent models for biomedical purposes.
Education & Training
Degree-Granting Education
| 2013 | University of Sydney, Sydney, AU, Production and characterization of new transgenic mouse models of neurodegeneration, Ph.D |
| 2002 | University of Bordeaux 1, Bordeaux 1, FR, Psychopharmacology and Pharmaceutical Research, MA |
| 2001 | University of Bordeaux 1, Bordeaux 1, FR, Cell Biology and Physiology, M.S |
Postgraduate Training
| 2013-2015 | Postdoctoral research fellow in the Dementia Research Unit, School of Medical Sciences - University of New South Wales, Sydney |
Experience & Service
Faculty Academic Appointments
Assistant Professor, Macquarie University, Sydney, 2018 - 2023
Research Associate, Department of School of Medical Sciences, The University of New South Wales, Sydney, New South Wales, 2016 - 2018
Other Professional Positions
Manager of the Transgenic Animal Unit, School of Medical Sciences, University of New South Wales, Sydney, 2016 - 2018
Senior Technical Officer/Medical Laboratory Technician, The Brain and Mind Research Institute (University of Sydney), Sydney, 2007 - 2013
Laboratory Technician, CNS centre of F. Hoffmann-La Roche Ltd, Basel, 2002 - 2007
Extramural Institutional Committee Activities
Reviewer, GSBS student admission committee, The University of Texas MD Anderson Cancer Center, 2025 - Present
Editorial Activities
Guest editor, International Journal of Molecular Sciences (IJMS), 2024 - Present
Associate Editor, Frontiers in Genome Editing (section Genome Editing in Animals), 2022 - 2024
Honors & Awards
| 2025 - Present | Multi-Year Appointment Award on the research faculty appointment track, MD Anderson Cancer Center |
| 2023 | 3Rs award: 18th International Society for Transgenic Technologies (ISTT) – Awarded for outstanding and original work that has or could have major impacts on the replacement, reduction or refinement of the use of animals in research, Houston, TX |
| 2019 | Travel grant for the fourth Oceania mouse Transgenic and Assisted Reproductive Technique symposium, Adelaide |
| 2018 | Travel grant for the first International FoxG1 symposium, San Diego, CA |
| 2015 | Travel grant for the international course on Advances in the Generation of Genetically Modified Animal Models, Montevideo, Uruguay |
| 2014 | ISTT Registration Award for the 2014 Transgenic Technology meeting, Edinburgh, Scotland |
| 2010 - 2013 | Phillip Jacoby Scholarship in Alzheimer’s Dementia Research, University of Sydney |
Professional Memberships
Selected Presentations & Talks
National Presentations
- 2023. Long Read Sequencing reveals high frequency of bystander mutations following AAV-driven electroporation of CRISPR RNP complexes in mouse zygotes. Conference. 18th International Society for Transgenic Technologies (ISTT) meeting. Houston, Texas, US.
- 2023. Long noncoding RNAs modulate spatial learning and motor activity. Conference. Long noncoding RNAs modulate spatial learning and motor activity. Society for Neuroscience meeting (SFN). Washington, WA, US.
- 2022. Antisense oligonucleotide therapy mitigates FOXG1 syndrome in vivo. Conference. 3rd International FoxG1 symposium. Fort Lauderdale, FL, US.
- 2022. PLP1-targeting antisense oligonucleotides improve FOXG1 syndrome mice. Society for Neuroscience conference. Conference. PLP1-targeting antisense oligonucleotides improve FOXG1 syndrome mice. Society for Neuroscience conference. San Diego, CA, US.
- 2020. Orexin knockout BPH/2J hypertensive mice still have elevated basal blood pressure but lower stress reactivity. Hypertension Council meeting. American Heart Association's (AHA). Conference. Orexin knockout BPH/2J hypertensive mice still have elevated basal blood pressure but lower stress reactivity. Hypertension Council meeting. American Heart Association's (AHA), US.
- 2018. Generating new animal models of rare genetic disorders: focusing on FoxG1 syndrome. Society for Neuroscience meeting. Conference. Generating new animal models of rare genetic disorders: focusing on FoxG1 syndrome. Society for Neuroscience meeting. San Diego, CA, US.
- 2017. Sheep as models for Batten disease - update on current Australian research. Batten Disease Support and Research Association (BDSRA) conference. Conference. Sheep as models for Batten disease - update on current Australian research. Batten Disease Support and Research Association (BDSRA) conference. Pittsburgh, PA, US.
International Presentations
- 2025. Long Read Sequencing reveals unexpected on-target mutations following AAV-driven gene editing in mouse zygotes. Conference. 5th Oceania mouse Transgenic Technologies symposium. Melbourne, AU.
- 2022. Distribution of populations of auditory and vestibular neurons resolved in a peripherin promotor-driven transgenic reporter mouse. Australasian Auditory Neuroscience Workshop. Conference. Distribution of populations of auditory and vestibular neurons resolved in a peripherin promotor-driven transgenic reporter mouse. Australasian Auditory Neuroscience Workshop. Melbourne, AU.
- 2022. Optimization of gene transfer methods for generating genetically modified animals. Renal Scientists workshop. Australian and New Zealand Society of Nephrology. Conference. Optimization of gene transfer methods for generating genetically modified animals. Renal Scientists workshop. Australian and New Zealand Society of Nephrology. Sydney, AU.
- 2019. Seamless generation of clinically relevant animal models using CRISPR and TALEN. Thermo Fisher Scientific Innovations in Cell and Gene Therapy seminar. Conference. Seamless generation of clinically relevant animal models using CRISPR and TALEN. Thermo Fisher Scientific Innovations in Cell and Gene Therapy seminar. Sydney, AU.
- 2019. Genome editing across species by direct electroporation of embryos. Merck CRISPR core directors meeting - Kobe. Conference. Genome editing across species by direct electroporation of embryos. Merck CRISPR core directors meeting - Kobe. Kobe, JP.
- 2019. Generation of a CLN7 KI sheep model of Batten disease. 15th International Society for Transgenic Technology Meeting. Conference. Generation of a CLN7 KI sheep model of Batten disease. 15th International Society for Transgenic Technology Meeting. Kobe, JP.
- 2019. Generation of CRISPR/Cas9 genome edited sheep embryos in preparation to create an ovine CLN7 Batten disease research flock. Second Asia-Pacific Lysosomal Diseases New Zealand (LDNZ) conference. Conference. Generation of CRISPR/Cas9 genome edited sheep embryos in preparation to create an ovine CLN7 Batten disease research flock. Second Asia-Pacific Lysosomal Diseases New Zealand (LDNZ) conference. Auckland, NZ.
- 2019. Seamless generation of clinically and industrially relevant animal models using CRISPR and TALEN. 4st Oceania mouse TART symposium. Conference. Seamless generation of clinically and industrially relevant animal models using CRISPR and TALEN. 4st Oceania mouse TART symposium. Adelaide, AU.
- 2018. Investigating the pathomechanisms of FoxG1 syndrome. Combined ASBMB, ASPS, and ANZSCDB Annual meetings (Combio). Conference. Investigating the pathomechanisms of FoxG1 syndrome. Combined ASBMB, ASPS, and ANZSCDB Annual meetings (Combio). Sydney, AU.
- 2018. Does an experience in the private sector really make your career “non-academic”? Combined ASBMB, ASPS, and ANZSCDB Annual meetings (ComBio). Conference. Does an experience in the private sector really make your career “non-academic”? Combined ASBMB, ASPS, and ANZSCDB Annual meetings (ComBio). Sydney, AU.
- 2018. Generation of a sheep model of CLN7 Batten disease using the CRISPR/Cas9 genome editing system - preliminary results and ethical reflections. Queenstown Research Week (QRW) conference. Conference. Generation of a sheep model of CLN7 Batten disease using the CRISPR/Cas9 genome editing system - preliminary results and ethical reflections. Queenstown Research Week (QRW) conference. Queenstown, AU.
- 2017. CRISPR/Cas9 mediated genome editing by electroporation of mouse oocytes. 14th International Society for Transgenic Technology Meeting. Conference. CRISPR/Cas9 mediated genome editing by electroporation of mouse oocytes. 14th International Society for Transgenic Technology Meeting. Salt Lake City, US.
- 2017. Optimized electroporation of mouse oocytes for CRISPR editing. 3rd Oceania mouse TART symposium. Conference. Optimized electroporation of mouse oocytes for CRISPR editing. 3rd Oceania mouse TART symposium. Sydney, AU.
- 2017. CRISPR/Cas9 mediated genome editing by electroporation of mouse oocytes. 3rd Oceania mouse TART symposium. Conference. CRISPR/Cas9 mediated genome editing by electroporation of mouse oocytes. 3rd Oceania mouse TART symposium. Sydney, AU.
- 2017. Introduction to transgenic technologies. Australian and New Zealand Laboratory Animal Association (ANZLAA) annual conference. Conference. Introduction to transgenic technologies. Australian and New Zealand Laboratory Animal Association (ANZLAA) annual conference. Sydney, AU.
- 2017. Generation of a New tau Knockout Mouse Model by CRISPR/CAS9 Genome Editing. 37th Australian Neuroscience Society (ANS) Conference. Conference. Generation of a New tau Knockout Mouse Model by CRISPR/CAS9 Genome Editing. 37th Australian Neuroscience Society (ANS) Conference. Sydney, AU.
- 2016. A fast, easy and reliable method for the generation of KO mice using CRISPR/Cas9 by a single person: a small laboratory perspective. 13th International Society for Transgenic Technology Meeting. Conference. A fast, easy and reliable method for the generation of KO mice using CRISPR/Cas9 by a single person: a small laboratory perspective. 13th International Society for Transgenic Technology Meeting. Prague, US.
- 2016. CRISPR/Cas9 genome editing in mice: streamlining the process for fast generation of disease models. The Combined Australian Association of Chinese Biomedical Scientists (AACBS) annual scientific meeting. Conference. CRISPR/Cas9 genome editing in mice: streamlining the process for fast generation of disease models. The Combined Australian Association of Chinese Biomedical Scientists (AACBS) annual scientific meeting. Sydney, AU.
- 2016. CRISPR/Cas9 genome editing in mice: streamlining the process for fast generation of disease models. UTS / Kolling Institute / RNSH - 33rd Combined Health Science New Horizons Conference. Conference. CRISPR/Cas9 genome editing in mice: streamlining the process for fast generation of disease models. UTS / Kolling Institute / RNSH - 33rd Combined Health Science New Horizons Conference. Sydney, AU.
- 2015. Assessment of the role of Parkinson’s Disease associated ATP13A2/PARK9 in the in vivo inter-neuronal spread of alpha-synuclein pathology. Gordon Research conference. Conference. Assessment of the role of Parkinson’s Disease associated ATP13A2/PARK9 in the in vivo inter-neuronal spread of alpha-synuclein pathology. Gordon Research conference. New London, GB.
- 2015. Induction and propagation of Tau pathology in a P301S mutant tau transgenic mouse model. ISN-APSN-ANS conference. Conference. Induction and propagation of Tau pathology in a P301S mutant tau transgenic mouse model. ISN-APSN-ANS conference. Cairns, AU.
- 2015. A novel TDP-43 transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. AD/PD conference. Conference. A novel TDP-43 transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. AD/PD conference. Nice, FR.
- 2015. Fast, easy and reliable method for the generation of KO mice using CRISPR/Cas9. 2nd Oceania Transgenic Technology/Cryopreservation Symposium. Conference. Fast, easy and reliable method for the generation of KO mice using CRISPR/Cas9. 2nd Oceania Transgenic Technology/Cryopreservation Symposium. Hobart, AU.
- 2014. A second-generation inducible and non-leaky system for gene expression in transgenic mice. 12th International Society for Transgenic Technology Meeting. Conference. A second-generation inducible and non-leaky system for gene expression in transgenic mice. 12th International Society for Transgenic Technology Meeting. Edinburgh, GB.
- 2013. A second-generation inducible and non-leaky system for gene expression in transgenic mice. Combined ASBMB, ASPS, and ANZSCDB Annual meetings (ComBio). Conference. A second-generation inducible and non-leaky system for gene expression in transgenic mice. Combined ASBMB, ASPS, and ANZSCDB Annual meetings (ComBio). Perth, AU.
- 2013. Improving DNA construct quality and success rate. 1st Oceania Transgenic Technology /Cryopreservation Symposium. Conference. Improving DNA construct quality and success rate. 1st Oceania Transgenic Technology /Cryopreservation Symposium. Brisbane, AU.
Formal Peers
- 2025. Streamlined generation of mouse models for Cancer. Houston, TX, US.
- 2024. Generating and characterizing animal models of human neurodevelopmental disorders. Houston, Texas, US.
- 2024. Generating and characterizing animal models of human neurodevelopmental disorders. Houston, Texas, US.
- 2024. Genetically Engineered Mouse Facility (GEMF) and Laboratory Animal Genetic Services (LAGS): cutting-edge resources for the generation and characterization of animal models. Houston, Texas, US.
- 2024. Cutting-edge genome editing for the generation of animal models of human disorders. Houston, Texas, US.
- 2023. Update on CRISPR-READI for large KI targeting.
- 2023. Cutting-edge genome editing for the generation of animal models of human disorders. Houston, Texas, US.
- 2019. Improving the methodology for the generation of genetically modified animals across species. Invited, SG.
- 2019. Genome Editing at Macquarie (GEM): a unique platform for the generation of genetically modified animals. Invited.
- 2019. Genome Editing at Macquarie (GEM): a unique platform for the generation of genetically modified animals. Invited, AU.
- 2018. Combining the latest developments in Assisted Reproductive Techniques (ART) and Genome Editing for the production of animal models of human disorders. Invited, CN.
- 2017. Gene editing in embryos. 4th NSW reproduction forum. Invited, AU.
- 2016. The Transgenic Animal Unit (TAU): delivering animal models of human conditions in record time. Mark Wainwright Analytical Centre annual meeting. Invited.
- 2016. Generating new mouse models of neurodegeneration and other cytoskeleton related conditions. EMBL Cytoskeleton Consortium. Invited.
- 2016. From recombinant DNA to genome editing: four decades of mouse models and beyond. Anatomy, Physiology & Pharmacology Seminar. Invited.
- 2015. Genome engineering and production of transgenic mouse models of diseases. Combined CCI/BRC/BRIL/GSBME meeting. Invited.
- 2015. Genome engineering and production of transgenic mouse models of Neurodegeneration. Masters in Brain Science. Invited.
- 2015. Update on ALS mouse models including the new C9orf72 model. 6th Forefront Scientific meeting. Invited, AU.
- 2014. Transgenesis and genome editing in mice. Masters in Brain Science. Invited, AU.
- 2013. Principles of pronuclear injection for the generation of transgenic mice. Masters in Brain Science. Invited, AU.
- 2013. Production and characterization of new transgenic mouse models of neurodegeneration. Special seminar. Invited, AU.
- 2013. Update on the development of genetically engineered animal models including ZFN/TALEN approaches to genome editing. Special seminar. Invited, AU.
Grant & Contract Support
| Date: | 2025 - Present |
| Title: | MD Anderson institutional support |
| Funding Source: | MDACC |
| Role: | PI |
| Date: | 2023 - Present |
| Title: | MD Anderson Cancer Center Support Grant |
| Funding Source: | NCI |
| Role: | Key |
| ID: | P30CA016672 |
| Date: | 2023 |
| Title: | Lab and mouse handling equipment and rack washer for CAF |
| Funding Source: | Macquarie Research Infrastructure Scheme (MQRIS) |
| Role: | Collaborator |
| Date: | 2023 |
| Title: | Small-animal neurobiology platform |
| Funding Source: | Macquarie Research Infrastructure Scheme (MQRIS) |
| Role: | Collaborator |
| Date: | 2022 |
| Title: | Rapid assessment of genome editing outcomes in mice using nanopore-based adaptive sampling |
| Funding Source: | Macquarie-Mahidol Universities seed grant |
| Role: | PI |
| Date: | 2021 - 2023 |
| Title: | Functional analysis of long noncoding RNAs expressed in the brain |
| Funding Source: | Australian Research Council - Discovery Project |
| Role: | PI |
| Date: | 2021 - 2023 |
| Title: | Novel therapeutic strategies targeting TDP-43 in Motor Neuron Disease |
| Funding Source: | Betty and John Laidlaw MND Research Prize |
| Role: | Collaborator |
| Date: | 2020 - 2022 |
| Title: | Develop, advance, and apply vertebrate genome editing technologies to deliver projects in biosecurity, health, and agriculture |
| Funding Source: | CSIRO-MQ collaborative research agreement |
| Role: | PI |
| Date: | 2020 - 2022 |
| Title: | Exploring technical feasibility of vertebrate pest population control with CRISPR Base-editor methods |
| Funding Source: | CSIRO-MQ collaborative research agreement |
| Role: | Collaborator |
| Date: | 2017 - 2020 |
| Title: | Investigating the pathomechanisms of FOXG1 syndrome |
| Funding Source: | Kushagra Singha FoxG1 Research support |
| Role: | PI |
| Date: | 2017 - 2020 |
| Title: | Defining the spatial and temporal regulation of neurite branching |
| Funding Source: | ARC Discovery project |
| Role: | Collaborator |
| Date: | 2017 |
| Title: | Research Infrastructure Scheme |
| Funding Source: | Transgenic Animal Facility support staff salary |
| Role: | PI |
| Date: | 2016 |
| Title: | Research Infrastructure Scheme |
| Funding Source: | Transgenic Animal Facility support staff salary |
| Role: | PI |
| Date: | 2016 |
| Title: | Improving the frequency of targeted integration of large transgenes using CRISPR/Cas9 and long single-strand oligonucleotides (ssOligos) |
| Funding Source: | UNSW Analytical Centre Research Grant |
| Role: | PI |
| Date: | 2016 |
| Title: | Research Infrastructure Scheme |
| Funding Source: | Real-time microcirculation imaging with Laser Speckle Contrast Imaging (LSCI) |
| Role: | Collaborator |
| Date: | 2014 - 2017 |
| Title: | LRRK2 and type-1 interferon |
| Funding Source: | Michael J Fox Foundation LRRK2 challenge 2014 award |
| Role: | Collaborator |
Selected Publications
Peer-Reviewed Articles
- Chisholm CG, Bartlett R, Brown ML, Proctor EJ, Farrawell NE, Gorman J, Delerue F, Ittner LM, Vine-Perrow KL, Ecroyd H, Cashman NR, Saunders DN, McAlary L, Lum JS, Yerbury JJ. Development of a targeted BioPROTAC degrader selective for misfolded SOD1. Nat Commun 16(1):9713, 2025. e-Pub 2025. PMID: 41213972.
- Luqman, MW, Jenjaroenpun, P, Spathos, J, Shingte, N, Cummins, M, Nimsamer, P, Ittner, LM, Wongsurawat, T, Delerue, F. Long read sequencing reveals transgene concatemerization and vector sequences integration following AAV-driven electroporation of CRISPR RNP complexes in mouse zygotes. Frontiers in Genome Editing 7, 2025. e-Pub 2025. PMID: 40535113.
- Pearson, LJ, Pinyon, JL, Cederholm, J, Jonquieres, G, Bartlett, F, Vázquez-Campos, X, Delerue, F, Ittner, LM, Housley, GD. Developmental differentiation of mouse inner ear neuron subpopulations resolved with a peripherin-promoter reporter within the Grm8 locus. Scientific reports 15(1), 2025. e-Pub 2025. PMID: 40133378.
- Teboul L, Amos-Landgraf J, Benavides FJ, Birling MC, Brown SDM, Bryda E, Bunton-Stasyshyn R, Chin HJ, Crispo M, Delerue F, Dobbie M, Franklin CL, Fuchtbauer EM, Gao X, Golzio C, Haffner R, Hérault Y, Hrabe de Angelis M, Lloyd KCK, Magnuson TR, Montoliu L, Murray SA, Nam KH, Nutter LMJ, Pailhoux E, Pardo Manuel de Villena F, Peterson K, Reinholdt L, Sedlacek R, Seong JK, Shiroishi T, Smith C, Takeo T, Tinsley L, Vilotte JL, Warming S, Wells S, Whitelaw CB, Yoshiki A, Resource Association AMM, infrastructure C, consortium I, Genome Society IM, Phenotyping Consortium IM, Transgenic Technologies ISF, Resource MM, Centers R, Australia P, Resource RR, Center R, Pavlovic G. Improving laboratory animal genetic reporting: LAG-R guidelines. Nat Commun 15(1), 2024. e-Pub 2024. PMID: 38956430.
- Tan DCS, Jung S, Deng Y, Morey N, Chan G, Bongers A, Ke YD, Ittner LM, Delerue F. PLP1-Targeting Antisense Oligonucleotides Improve FOXG1 Syndrome Mice. Int J Mol Sci 25(19), 2024. e-Pub 2024. PMID: 39409184.
- Ke YD, van Hummel A, Au C, Chan G, Lee WS, van der Hoven J, Przybyla M, Deng Y, Sabale M, Morey N, Bertz J, Feiten A, Ippati S, Stevens CH, Yang S, Gladbach A, Haass NK, Kril JJ, Blair IP, Delerue F, Ittner LM. Targeting 14-3-3θ-mediated TDP-43 pathology in amyotrophic lateral sclerosis and frontotemporal dementia mice. Neuron 112(8):1249-1264.e8, 2024. e-Pub 2024. PMID: 38366598.
- Shvetcov A, Thomson S, Spathos J, Cho AN, Wilkins HM, Andrews SJ, Delerue F, Couttas TA, Issar JK, Isik F, Kaur S, Drummond E, Dobson-Stone C, Duffy SL, Rogers NM, Catchpoole D, Gold WA, Swerdlow RH, Brown DA, Finney CA. Blood-Based Transcriptomic Biomarkers Are Predictive of Neurodegeneration Rather Than Alzheimer's Disease. Int J Mol Sci 24(19), 2023. e-Pub 2023. PMID: 37834458.
- Finney CA, Delerue F, Gold WA, Brown DA, Shvetcov A. Artificial intelligence-driven meta-analysis of brain gene expression identifies novel gene candidates and a role for mitochondria in Alzheimer's disease. Comput Struct Biotechnol J 21:388-400, 2023. e-Pub 2023. PMID: 36618979.
- Morey N, Przybyla M, van der Hoven J, Ke YD, Delerue F, van Eersel J, Ittner LM. Treatment of epilepsy using a targeted p38γ kinase gene therapy. Sci Adv 8(48):eadd2577, 2022. e-Pub 2022. PMID: 36459557.
- Deng Y, Bi M, Delerue F, Forrest SL, Chan G, van der Hoven J, van Hummel A, Feiten AF, Lee S, Martinez-Valbuena I, Karl T, Kovacs GG, Morahan G, Ke YD, Ittner LM. Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer's disease. Acta Neuropathol 144(4):637-650, 2022. e-Pub 2022. PMID: 35780436.
- Klugmann M, Kalotay E, Delerue F, Ittner LM, Bongers A, Yu J, Morris MJ, Housley GD, Fröhlich D. Developmental delay and late onset HBSL pathology in hypomorphic Dars1M256L mice. Neurochem Res 47(7):1972-1984, 2022. e-Pub 2022. PMID: 35357600.
- Delerue F, Ittner LM. Microinjection of Zygotes for CRISPR/Cas9-Mediated Insertion of Transgenes into the Murine Rosa26 Safe Harbor. Methods Mol Biol 2495:115-128, 2022. e-Pub 2022. PMID: 35696031.
- Ittner A, Asih PR, Tan ARP, Prikas E, Bertz J, Stefanoska K, Lin Y, Volkerling AM, Ke YD, Delerue F, Ittner LM. Reduction of advanced tau-mediated memory deficits by the MAP kinase p38γ. Acta Neuropathol 140(3):279-294, 2020. e-Pub 2020. PMID: 32725265.
- Yang L, Chen Z, Stout ES, Delerue F, Ittner LM, Wilkins MR, Quinlan KGR, Crossley M. Methylation of a CGATA element inhibits binding and regulation by GATA-1. Nat Commun 11(1):2560, 2020. e-Pub 2020. PMID: 32444652.
- Brettle M, Stefen H, Djordjevic A, Fok SYY, Chan JW, van Hummel A, van der Hoven J, Przybyla M, Volkerling A, Ke YD, Delerue F, Ittner LM, Fath T. Developmental Expression of Mutant PFN1 in Motor Neurons Impacts Neuronal Growth and Motor Performance of Young and Adult Mice. Front Mol Neurosci 12:231, 2019. e-Pub 2019. PMID: 31611772.
- von Jonquieres G, Spencer ZHT, Rowlands BD, Klugmann CB, Bongers A, Harasta AE, Parley KE, Cederholm J, Teahan O, Pickford R, Delerue F, Ittner LM, Fröhlich D, McLean CA, Don AS, Schneider M, Housley GD, Rae CD, Klugmann M. Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy. Acta Neuropathol 135(1):95-113, 2018. e-Pub 2018. PMID: 29116375.
- Tan DCS, Yao S, Ittner A, Bertz J, Ke YD, Ittner LM, Delerue F. Generation of a New Tau Knockout (tau?ex1) Line Using CRISPR/Cas9 Genome Editing in Mice. J Alzheimers Dis 62(2):571-578, 2018. e-Pub 2018. PMID: 29480201.
- Delerue F, Ittner LM. Generation of Genetically Modified Mice through the Microinjection of Oocytes. J Vis Exp(124), 2017. e-Pub 2017. PMID: 28654070.
- Bodea LG, Evans HT, Van der Jeugd A, Ittner LM, Delerue F, Kril J, Halliday G, Hodges J, Kiernan MC, Götz J. Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model. Aging Cell 16(2):377-386, 2017. e-Pub 2017. PMID: 28160413.
- Pleines I, Woods J, Chappaz S, Kew V, Foad N, Ballester-Beltrán J, Aurbach K, Lincetto C, Lane RM, Schevzov G, Alexander WS, Hilton DJ, Astle WJ, Downes K, Nurden P, Westbury SK, Mumford AD, Obaji SG, Collins PW, Delerue F, Ittner LM, Bryce NS, Holliday M, Lucas CA, Hardeman EC, Ouwehand WH, Gunning PW, Turro E, Tijssen MR, Kile BT. Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia. J Clin Invest 127(3):814-829, 2017. e-Pub 2017. PMID: 28134622.
- Ittner A, Chua SW, Bertz J, Volkerling A, van der Hoven J, Gladbach A, Przybyla M, Bi M, van Hummel A, Stevens CH, Ippati S, Suh LS, Macmillan A, Sutherland G, Kril JJ, Silva AP, Mackay JP, Poljak A, Delerue F, Ke YD, Ittner LM. Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer's mice. Science 354(6314):904-908, 2016. e-Pub 2016. PMID: 27856911.
- Chandrakanthan V, Yeola A, Kwan JC, Oliver RA, Qiao Q, Kang YC, Zarzour P, Beck D, Boelen L, Unnikrishnan A, Villanueva JE, Nunez AC, Knezevic K, Palu C, Nasrallah R, Carnell M, Macmillan A, Whan R, Yu Y, Hardy P, Grey ST, Gladbach A, Delerue F, Ittner L, Mobbs R, Walkley CR, Purton LE, Ward RL, Wong JW, Hesson LB, Walsh W, Pimanda JE. PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells. Proc Natl Acad Sci U S A 113(16):E2306-15, 2016. e-Pub 2016. PMID: 27044077.
- Ke YD, van Hummel A, Stevens CH, Gladbach A, Ippati S, Bi M, Lee WS, Krüger S, van der Hoven J, Volkerling A, Bongers A, Halliday G, Haass NK, Kiernan M, Delerue F, Ittner LM. Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS. Acta Neuropathol 130(5):661-78, 2015. e-Pub 2015. PMID: 26437864.
- Delerue F, White M, Ittner LM. Inducible, tightly regulated and non-leaky neuronal gene expression in mice. Transgenic Res 23(2):225-33, 2014. e-Pub 2014. PMID: 24214494.
- Delerue F, Sjollema G, Whittle B, Krüger S, Andrews D, Götz J. Single nucleotide variants (SNVs) define senescence-accelerated SAMP8 mice, a model of a geriatric condition. J Alzheimers Dis 36(2):349-63, 2013. e-Pub 2013. PMID: 23609764.
- Mendoza J, Lopez-Lopez C, Revel FG, Jeanneau K, Delerue F, Prinssen E, Challet E, Moreau JL, Grundschober C. Dimorphic effects of leptin on the circadian and hypocretinergic systems of mice. J Neuroendocrinol 23(1):28-38, 2011. e-Pub 2011. PMID: 20874776.
- Ittner LM, Ke YD, Delerue F, Bi M, Gladbach A, van Eersel J, Wölfing H, Chieng BC, Christie MJ, Napier IA, Eckert A, Staufenbiel M, Hardeman E, Götz J. Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell 142(3):387-97, 2010. e-Pub 2010. PMID: 20655099.
- van Eersel J, Ke YD, Liu X, Delerue F, Kril JJ, Götz J, Ittner LM. Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proc Natl Acad Sci U S A 107(31):13888-93, 2010. e-Pub 2010. PMID: 20643941.
- Ke YD, Delerue F, Gladbach A, Götz J, Ittner LM. Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer's disease. PLoS One 4(11):e7917, 2009. e-Pub 2009. PMID: 19936237.
- Leblond L, Beaufort C, Delerue F, Durkin TP. Differential roles for nicotinic and muscarinic cholinergic receptors in sustained visuo-spatial attention? A study using a 5-arm maze protocol in mice. Behav Brain Res 128(1):91-102, 2002. e-Pub 2002. PMID: 11755693.
Review Articles
- Shvetcov A, Ruitenberg MJ, Delerue F, Gold WA, Brown DA, Finney CA. The neuroprotective effects of estrogen and estrogenic compounds in spinal cord injury. Neurosci Biobehav Rev 146:105074, 2023. e-Pub 2023. PMID: 36736846.
- Delerue F, Ittner LM. Genome Editing in Mice Using CRISPR/Cas9: Achievements and Prospects. Clon Transgen(4):135, 2015. e-Pub 2015.
Professional Educational Materials
- Delerue F. Techniques d’ingénierie reproductive de la souris, manuel technique. French translation of “Reproductive engineering techniques in mice, technical manual”. Nakagata N. (3rd Edition), 2016.
Book Chapters
- Benavides F, Delerue F, Crispo M. In: Genetically Altered Rodents. In: Rodent Quality Control: Genes and Bugs. Springer Nature (invited), 2024.
- Delerue F, Ittner LM. In: Microinjection of zygotes for CRISPR/Cas9 mediated insertion of transgenes into the murine Rosa26 safe harbour. In Applications of Genome Modulation and Editing. Springer press (invited), 2022.
- van Eersel J, Delerue F, Ittner LM, Ke YD. In: Alzheimer’s Disease and Frontotemporal Lobar Degeneration: Mouse Models. In: Neurodegenerative Diseases: Clinical Aspects, Molecular Genetics and Biomarkers for Early Diagnosis and Treatment. Springer press (invited), 2013.
Patient Reviews
CV information above last modified March 18, 2026