Fada Guan, Ph.D.
Department of Radiation Physics, Division of Radiation Oncology
Present Title & Affiliation
Primary Appointment
Assistant Professor, Department of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Dual/Joint/Adjunct Appointment
Associate Faculty Member, The University of Texas Graduate School of Biomedical Sciences, Houston, TX
Education & Training
Degree-Granting Education
| 2012 | Texas A&M University, College Station, TX, USA, PHD, Nuclear Engineering, Advisor: John W. Poston, Sr., Ph.D |
| 2009 | Texas A&M University, College Station, TX, USA, MS, Health Physics, Advisor: John W. Poston, Sr., Ph.D |
| 2005 | Tsinghua University, Beijing, CHN, BE, Nuclear Engineering, Advisors: Prof. Huaibi Chen & Prof. Quanfeng Li |
Postgraduate Training
| 2012-2016 | Medical Physics Certificate Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX |
| 2012-2016 | Postdoctoral Fellow, Medical Physics, The University of Texas MD Anderson Cancer Center, Houston, TX |
Honors & Awards
| 2019 | Early Career Investigator Travel Award, Radiation Research Society |
| 2018 | Outstanding Reviewer Awards 2017 for Biomedical Physics & Engineering Express, IOP Publishing |
| 2018 | Early Career Investigator Travel Award, Radiation Research Society |
| 2017 | Outstanding Reviewer Awards 2016 for Physics in Medicine and Biology, IOP Publishing |
| 2016 | Highlights of 2015 (with Geng et al.), Journal of Radiological Protection |
| 2016 | Research Seed Funding Initiative Award, American Association of Physicist in Medicine |
| 2015 | AMGEN Award in Basic Science Research, Finalist, Trainee Research Day, UT MD Anderson Cancer Center |
| 2014 | Scholars-in-Training Travel Award, Radiation Research Society |
| 2010 | Student Education Grant, STC, Health Physics Society |
Professional Memberships
Selected Publications
Peer-Reviewed Articles
- Shao W, Tang X, Geng C, Shu D, Gong C, Zhang X, Guan F. Investigation of irregular radiation field based proton therapy using conformal dose layer stacking method. Int J Rad Res 18(2), 2020. e-Pub 2020.
- Ma D, Bronk L, Kerr M, Sobieski M, Chen M, Geng C, Yiu J, Wang X, Sahoo N, Cao W, Zhang X, Stephan C, Mohan R, Grosshans DR, Guan F. Exploring the Advantages of Intensity-modulated Proton Therapy: Experimental Validation of Biological Effects using Two Different Beam Intensity-modulation Patterns. Sci Rep 10(1):3199, 2020. e-Pub 2020. PMID: 32081928.
- Darne CD, Alsanea F, Robertson DG, Guan F, Pan T, Grosshans D, Beddar S. A proton imaging system using a volumetric liquid scintillator: a preliminary study. Biomed Phys Eng Express 5(4), 2019. e-Pub 2019. PMID: 32194988.
- Geng C, Ai Y, Tang X, Shu D, Gong C, Guan F. A Monte Carlo study of pinhole collimated Cerenkov luminescence imaging integrated with radionuclide treatment. Australas Phys Eng Sci Med 42(2):481-487, 2019. e-Pub 2019. PMID: 30830649.
- Newpower M, Patel D, Bronk L, Guan F, Chaudhary P, McMahon SJ, Prise KM, Schettino G, Grosshans DR, Mohan R. Using the Proton Energy Spectrum and Microdosimetry To Model Proton Relative Biological Effectiveness. Int J Radiat Oncol Biol Phys 104(2):316-324, 2019. e-Pub 2019. PMID: 30731186.
- Yang P, Xu T, Gomez DR, Deng W, Wei X, Elhalawani H, Jin H, Guan F, Mirkovic D, Xu Y, Mohan R, Liao Z. Patterns of Local-Regional Failure after Intensity-Modulated Radiation Therapy or Passive Scattering Proton Therapy with Concurrent Chemotherapy for Non-Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys 103(1):123-131, 2019. e-Pub 2018. PMID: 30165127.
- Ge S, Wang X, Liao Z, Zhang L, Sahoo N, Yang J, Guan F, Mohan R. Potential for Improvements in Robustness and Optimality of Intensity-Modulated Proton Therapy for Lung Cancer with 4-Dimensional Robust Optimization. Cancers (Basel) 11(1), 2019. e-Pub 2019. PMID: 30609652.
- Guan F, Geng C, Carlson DJ, Ma DH, Bronk L, Gates D, Wang X, Kry SF, Grosshans D, Mohan R. A Mechanistic Relative Biological Effectiveness Model-based Biological Dose Optimization for Charged Particle Radiobiology Studies. Phys Med Biol 64(1):015008, 2018. e-Pub 2018. PMID: 30523805.
- Geng C, Gates D, Bronk L, Ma D, Guan F. Physical Parameter Optimization Scheme for Radiobiological Studies of Charged Particle Therapy. Phys Med 51:13-21, 2018. e-Pub 2018. PMID: 30278981.
- Jiang B, Wang X, Zhang Y, Guan F, Li Y, Wang X, Zhu RX, Zhang X. Power-law relationship in the long-tailed sections of proton dose distributions. Sci Rep 8(1):10413, 2018. e-Pub 2018. PMID: 29991734.
- Guan F, Peeler C, Bronk L, Geng C, Taleei R, Randeniya S, Ge S, Mirkovic D, Grosshans D, Mohan R, Titt U. Erratum: "Analysis of the track- and dose-averaged LET and LET spectra in proton therapy using the geant4 Monte Carlo code" [Med. Phys. 42 (11), page range 6234-6247(2015)]. Med Phys 45(3):1302, 2018. e-Pub 2018. PMID: 29527697.
- Taleei R, Guan F, Peeler C, Bronk L, Patel D, Mirkovic D, Grosshans DR, Mohan R, Titt U. Erratum: "Monte Carlo simulations of 3 He ion physical characteristics in a water phantom and evaluation of radiobiological effectiveness" [Med. Phys. 43 (2), page range 761-776(2016)]. Med Phys 45(3):1301, 2018. e-Pub 2018. PMID: 29527699.
- Shao W, Tang X, Bai Y, Shu D, Geng C, Gong C, Guan F. Investigation of the dose perturbation effect for therapeutic beams with the presence of a 1.5 T transverse magnetic field in magnetic resonance imaging-guided radiotherapy. J Cancer Res Ther 14(1):184-195, 2018. e-Pub 2018. PMID: 29516984.
- Guan F, Geng C, Ma D, Bronk L, Kerr M, Li Y, Gates D, Kroger B, Sahoo N, Titt U, Grosshans D, Mohan R. RBE model-based biological dose optimization for proton radiobiology studies. Int J Part Ther 5(1):160-171, 2018. e-Pub 2018. PMID: 30338268.
- Patel D, Bronk L, Guan F, Peeler CR, Brons S, Dokic I, Abdollahi A, Rittmüller C, Jäkel O, Grosshans D, Mohan R, Titt U. Optimization of Monte Carlo particle transport parameters and validation of a novel high throughput experimental setup to measure the biological effects of particle beams. Med Phys 44(11):6061–6073, 2017. e-Pub 2017. PMID: 28880368.
- Mohan R, Peeler CR, Guan F, Bronk L, Cao W, Grosshans DR. Radiobiological Issues in Proton Therapy. Acta Oncol 56(11):1-7, 2017. e-Pub 2017. PMID: 28826292.
- Zhang Y, Kerr M, Guan F, Hartman J, Jiang B, Sahoo N, Zhu X, Gillin M, Qian W, Zhang X. Dose Calculation for Spot Scanning Proton Therapy with the Application of a Range Shifter. Biomed. Phys. Eng. Express 3(3), 2017. e-Pub 2017.
- Shu D, Tang X, Guan F, Geng C, Yu H, Gong C, Zhang X, Chen D. Analysis of the Relationship between Neutron Dose and Cerenkov Photons under Neutron Irradiation through Monte Carlo Method. Radiation Measurements 93, 2016. e-Pub 2016.
- Yepes P, Guan F, Kerr M, Randeniya S, Li Y, Bronk L, Liu A, Mirkovic D, Sahoo N, Titt U, Anand A, Mohan R. Validation of a Track-Repeating Algorithm Versus Measurements in Water for Proton Scanning Beams. Biomedical Physics & Engineering Express 2(3), 2016. e-Pub 2016.
- Geng C, Tang X, Guan F, Johns J, Vasudevan L, Gong C, Shu D, Chen D. GEANT4 calculations of neutron dose in radiation protection using a homogeneous phantom and a Chinese hybrid male phantom. Radiat Prot Dosimetry 168(4):433-40, 2016. e-Pub 2015. PMID: 26156875.
- Taleei R, Guan F, Peeler C, Bronk L, Patel D, Mirkovic D, Grosshans DR, Mohan R, Titt U. Monte Carlo simulations of ³He ion physical characteristics in a water phantom and evaluation of radiobiological effectiveness. Med Phys 43(2):761-76, 2016. PMID: 26843239.
- Geng C, Tang X, Gong C, Guan F, Johns J, Shu D, Chen D. A Monte Carlo-based radiation safety assessment for astronauts in an environment with confined magnetic field shielding. J Radiol Prot 35(4):777-88, 2015. e-Pub 2015. PMID: 26484984.
- Guan F, Peeler C, Bronk L, Geng C, Taleei R, Randeniya S, Ge S, Mirkovic D, Grosshans D, Mohan R, Titt U. Analysis of the track- and dose-averaged LET and LET spectra in proton therapy using the geant4 Monte Carlo code. Med Phys 42(11):6234-47, 2015. PMID: 26520716.
- Geng C, Tang X, Qian W, Guan F, Johns J, Yu H, Gong C, Shu D, Chen D. Calculations of S values and effective dose for the radioiodine carrier and surrounding individuals based on Chinese hybrid reference phantoms using the Monte Carlo technique. J Radiol Prot 35(3):707-17, 2015. e-Pub 2015. PMID: 26344387.
- Guan F, Johns JM, Vasudevan L, Zhang G, Tang X, Poston JW, Braby LA. A novel algorithm for solving the true coincident counting issues in Monte Carlo simulations for radiation spectroscopy. Health Phys 108(6):574-9, 2015. PMID: 25905518.
- Guan F, Bronk L, Titt U, Lin SH, Mirkovic D, Kerr MD, Zhu XR, Dinh J, Sobieski M, Stephan C, Peeler CR, Taleei R, Mohan R, Grosshans DR. Spatial mapping of the biologic effectiveness of scanned particle beams: towards biologically optimized particle therapy. Sci Rep 5:9850, 2015. e-Pub 2015. PMID: 25984967.
- You J, Zhao J, Wen X, Wu C, Huang Q, Guan F, Wu R, Liang D, Li C. Chemoradiation therapy using cyclopamine-loaded liquid-lipid nanoparticles and lutetium-177-labeled core-crosslinked polymeric micelles. J Control Release 202:40-8, 2015. e-Pub 2015. PMID: 25637565.
- Guan F, Ton P, Ge S, Zhao L. Anisotropic Diffusion Filtering for Ultrasound Speckle Reduction. Sci China Tech Sci 57(3):607-614, 2014.
- Guan F, Poston J, Braby L. Joint Application of Perl Scripts and MCNPX in Solving the Dynamic-Geometry Related Problems in Proton Beam Radiotherapy. Progress in Nuclear Science and Technology 2:176-180, 2011.
- Zhang J, Li Q, Chen H, Guo B, Guan F. Electron Beam Therapy Mode Analysis of Medical Linac by BEAM Code. Atomic Energy Science and Technology 43(7):667-672, 2009.
Abstracts
- Ma D, Bronk L, Titt U, Wen Z, Mohan R, Grosshans D, Guan F. Biological effects of proton, helium and carbon ions: comparison between high-throughput experimental data and model predictions. 59th Annual Conference of the Particle Therapy Co-Operative Group, Taipei, Taiwan, 2020.
- Wen Z, Guan F, Yang M. Phantom study of metal artifact effect on CT number using a single source dual energy (twin beam) CT scanner. 59th Annual Conference of the Particle Therapy Co-Operative Group, Taipei, Taiwan, 2020.
- Guan F, Ma D, Bronk L, Titt U, Grosshans D, Mohan R. Geant4-based Monte Carlo calculations of microdosimetric quantities of protons, helium and carbon ions for radiobiological studies. Joint International Conference on Supercomputing in Nuclear Applications + Monte Carlo 2020, Chiba, Japan, 2020. e-Pub 2020.
- Guan F, Ma D, Bronk L, Kerr M, Chen M, Wang X, Sahoo N, Grosshans D, Mohan R. The biological effects of intensity-modulated proton therapy: a comparison between high-throughput experimental results and model predictions. 65th Annual Meeting of Radiation Research Society, San Diego, CA, 2019.
- Ma D, Bronk L, Kerr M, Joycelyn Yiu, Chen M, Wang X, Sahoo N, Grosshans D, Mohan R, Guan F. Experimental comparison of the biological effects from two different beam scan patterns in intensity-modulated proton therapy. 65th Annual Meeting of Radiation Research Society, San Diego, CA, 2019.
- Yiu J, Kroger B, Kerr M, Georges S, Latario S, Sahoo N, Guan F, Bronk L, Mohan R, Grosshans D. The Role of BRCA1 Mutation on Cellular Response to X-ray and Proton Radiotherapy. 65th Annual Meeting of Radiation Research Society, San Diego, CA, 2019.
- Bronk L, Kroger B, Ma D, Kerr M, Tran K, Yiu J, Titt U, Sahoo N, Guan F, Mohan F, Grosshans D. High-throughput spatial mapping of DNA repair response along the range of an 81.4 MeV proton beam. 65th Annual Meeting of Radiation Research Society, San Diego, CA, 2019.
- Guan F, Bronk L, Ma D, Kerr M, Wang X, Sahoo N, Grosshans D, Mohan R. Comparing the Microdosimetric Kinetic Model-Predicted Proton RBE Values using Constant and Variable Quadratic Beta Coefficients. International Journal of Radiation Oncology•Biology•Physics, 2019.
- Darne C, Robertson D, Alsanea F, Guan F, Pan T, Grosshans D, Gautam A, Beddar S. A Proton Radiography System Design Using a Liquid Scintillator Detector. International Journal of Radiation Oncology•Biology•Physics, 2019.
- Hartzell S, Guan F, Vassiliev O, Taylor P, Peterson C, Kry S. Consistency of RBE Assessment in Carbon Ion Radiotherapy. Med Phys, 2019.
- Ma D, Kerr Matthew, Bronk L, Wang X, Sahoo N, Grosshans D, Mohan R, Guan F. Experimental Validation of the Enhancement of Biological Effects Using Enhanced-LET Proton Therapy. Med Phys, 2019.
- Hartzell S, Guan F, Vassiliev O, Peterson C, Taylor P, Kry S. Introducing Uncertainty to Measurement Based RBE Assessment in Carbon Ion Radiotherapy. Med Phys, 2019.
- Ma D, Bronk L, Kroger B, Kerr M, Wang X, Sahoo N, Mohan R, Grosshans D, Guan F. The effect of the microdosimetric spectrum on DNA double-strand break induction in proton therapy. 64th Annual Meeting of Radiation Research Society, Chicago, IL, 2018.
- Guan F, Geng C, Carlson D, Bronk L, Ma D, Wang X, Grosshans D, Mohan R. Development of easy-to-implement biological dose optimization algorithms for particle radiobiology. 64th Annual Meeting of Radiation Research Society, Chicago, IL, 2018.
- Guan F, Geng C, Carlson D, Bronk L, Gates D, Ma D, Kerr M, Wang X, Grosshans D, Mohan R. Repair-Misrepair-Fixation (RMF) Model-Based Biological Dose Optimization for Scanned Ion Beams. Med Phys, 2018. e-Pub 2018.
- Newpower M, Patel D, Bronk L, Guan F, Grosshans D, Titt U, Mohan R. Applying a Saturation Correction to the Microdosimetric Kinetic Model Prediction for the Relative Biological Effectiveness of a Carbon Ion Beam. Med Phys, 2018.
- Bronk L, Kroger B, Ma D, Kerr M, Tran K, Teubner F, Patel D, Titt U, Sahoo N, Sulman E, Guan F, Mohan R, Grosshans D. Mapping Biological Effects Along a Scanned 81.4 MeV Proton Beam: LET Modulation of the DNA Repair Response. Med Phys, 2018.
- Guan F, Bronk L, Kerr M, Ma D, Wang X, Sahoo N, Mohan R, Grosshans D. The correlation of biological effects and physical parameters in proton therapy. CPRIT's Innovations in Cancer Prevention and Research Conference V, Austin, TX, 2017.
- Patel D, Bronk L, Guan F, Peeler C, Brons S, Dokic I, Abdollahi A, Jaekel O, Grosshans D, Mohan R, Titt U. MO-RAM-GePD-TT-2: Effect of Physics Based Monte Carlo Parameterization On the Accuracy of Transport Quantities. Med Phys 44(6), 2017.
- Guan F, Bronk L, Kerr M, Ma D, Wang Y, Wang X, Li Y, Vassiliev O, Patel D, Titt U, Lin S, Grosshans D, Mohan R. TH-AB-605-8: Investigation of the Spatial Ionization Density Dependence of the DNA Damage in a Lung Cancer Cell Line with Proton Irradiations. Med Phys 44(6), 2017.
- Bronk L, Guan F, Ma D, Wang Y, Kerr M, Patel D, Titt U, Vassiliev O, Lin S, Mohan R, Grosshans D. SU-K-108-8: High-Throughput Proton Irradiations Uncover a Differential DNA Damage Repair Response to P53 Depletion in Two Lung Cancer Cell Lines. Med Phys 44(6), 2017.
- Newpower M, Vassiliev O, Guan F, Grosshans D, Bronk L, Mohan R. SU-K-108-2: A Novel Linear-Quadratic-Cubic Cell Survival Model for Proton Therapy Response Based On the Microdosimetric Quantity Specific Energy. Med Phys 44(6), 2017.
- Vassiliev O, Guan F, Bronk L, Grosshans D, Mohan R. SU-I-GPD-T-103: An LET-Based Model of Proton RBE Consistent with New High Accuracy RBE Data Measured Near Distal Fall-Off. Med Phys 44(6), 2017.
- Patel D, Bronk L, Guan F, Peeler C, Mirkovic D, Grosshans D, Jäkel O, Abdollahi A, Mohan R and Titt U. Experimental Investigation of RBE as a Function of Dose and LET. 25th Annual Meeting of the Council on Ionizing Radiation Measurements and Standards, Gaithersburg, MD, 2017.
- Guan F, Bronk L, Kerr M, Patel D, Peeler C, Mirkovic D, Titt U, Grosshans D, Mohan R.. Innovations in spatial mapping of the RBE of scanned particle beams. 24th International Conference On The Application of Accelerators In Research And Industry, Fort Worth, TX, 2016.
- Guan F, Bronk L, Kerr M, Wang X, Li Y, Peeler C, Sahoo N, Mirkovic D, Titt U, Grosshans D, Mohan R.. Spectral dependence of linear energy transfer on the biological effectiveness of therapeutic protons. 62nd Annual Meeting of Radiation Research Society, Waikoloa, Hawaii, 2016.
- Bronk L, Guan F, Kerr M, Ezhilarasan R, Sulman E, Mohan R, Grosshans D. Glioma stem cell survival as a function of dose and LET in a scanned proton beam using a spheroid growth assay. 62nd Annual Meeting of Radiation Research Society, Waikoloa, Hawaii, 2016.
- Guan F, Bronk L, Kerr M, Wang X, Li Y, Peeler C, Sahoo N, Patel D, Mirkovic D, Titt U, Grosshans D, Mohan R. Investigation of LET Spectral Dependence of the Biological Effects of Therapeutic Protons. Med Phys, 2016.
- Kerr M, Bronk L, Guan F, Patel D, Li Y, Wang X, Sahoo N, Peeler C, Titt U, Mirkovic D, Grosshans D, Mohan R. Spatial mapping of scanned proton biologic effect using the high-throughput technique, continued. Med Phys, 2016.
- Patel D, Bronk L, Guan F, Peeler C, Mirkovic D, Grosshans D, Jakel O, Abdollahi A, Titt U, Mohan R. Experimental Investigation of RBE of Lung Cancer Cell Lines as a Function of Dose and LET in Proton, Helium and Carbon Beams. Med Phys, 2016.
- Titt U, Bronk L, Patel D, Guan F, Peeler C, Mohan R.. In-vitro Survival of H460 and H1437 Cells as a Function of Dose and LET in Proton, Helium and Carbon beams. 55th Annual Conference of the Particle Therapy Co-Operative Group, Prague, Czech Republic, 2016.
- Guan F, Bronk L, Kerr M, Titt U, Wang X, Taleei R, Peeler C, Patel D, Mirkovic D, Grosshans D, Mohan R. Quantifying the Biological Effects of Therapeutic Protons by LET Spectrum Analysis. Med Phys, 2015.
- Guan F, Titt U, Patel D, Bronk L, Taleei R, Peeler C, Mirkovic D, Grosshans D, Jakel O, Mohan R. Experimental Design for High-Throughput In-Vitro RBE Measurements Using Protons, Helium and Carbon Ions. Med Phys, 2015.
- Peeler C, Taleei R, Guan F, Bronk L, Patel D, Titt U, Mirkovic D, Stewart R, Grosshans D, Mohan R. Relative Biological Effectiveness of Double-Strand Break Induction for Modeling Cell Survival in Pristine Proton Beams of Different Dose-Averaged Linear Energy Transfers. Med Phys, 2015.
- Taleei R, Peeler C, Guan F, Patel D, Titt U, Mirkovic D, Grosshans D, Mohan R. Modeling Biological Response to Proton Irradiation and Evaluating Its Potential Clinical Consequences. Med Phys, 2015.
- Geng C, Tang X, Guan F, Johns J, Vasudevan L, Gong C, Shu D, Chen D. A Comparative Study between Monte Carlo Code Geant4 and MCNP on Neutron Dose Calculations. 60th Annual Meeting of the Health Physics Society, Indianapolis, IN, 2015.
- Guan F, Bronk L, Kerr M, Titt U, Lin S, Mirkovic D, Zhu XR, Sobieski M, Stephan C, Mohan R, Grosshans D. A Novel Technique for High-throughput, High-precision Spatial Mapping of the Biologic Effectiveness of Therapeutic Proton Beam. 60th Annual Meeting of Radiation Research Society, Las Vegas, NV, 2014.
- Guan F, Bronk L, Kerr M, Titt U, Taleei R, Mirkovic D, Zhu XR, Grosshans D, Mohan R. The Effect of Particle Tracking Step Size Limit on Monte Carlo-Computed LET Spectrum of Therapeutic Proton Beams. Med Phys, 2014.
- Guan F, Johns J, Vasudevan L, Zhang G, Poston J, Braby L, Mohan R. A Novel Monte Carlo Algorithm for Solving the True Coincident Counting Issues in Monte Carlo Simulations for Gamma Spectroscopy. 59th Annual Meeting of the Health Physics Society, Baltimore, MD, 2014.
- Bronk L, Guan F, Kerr M, Titt U, Mirkovic D, Lin S, Mohan R, Grosshans D. High-throughput Mapping of Proton Biologic Effect. Med Phys, 2014.
- Randeniya S, Mirkovic D, Titt U, Guan F, Mohan R. Importance of energy dependent protons per MU calibration factors in IMPT dose calculations using Monte Carlo technique. Med Phys, 2014.
- Peeler C, Taleei R, Guan F, Bronk L, Grosshans D, Mirkovic D, Titt U, Mohan R. Application of the Repair-Misrepair-Fixation RBE Model to Describe the Results of High Resolution Proton Irradiation Cell Survival Experiments. Med Phys, 2014.
- Taleei R, Titt U, Peeler C, Guan F, Mirkovic D, Grosshans D, Mohan R. Modeling Physics Properties and Biologic Effects Induced by Proton and Helium Ions. Med Phys, 2014.
- Guan F, Titt U, Taleei R, Bangert M, Zhao L, Mirkovic D, Zhu Z, Bronk L, Kerr M, Sahoo N, Zhu XR, Gillin M, Carlson D, Grosshans D, Mohan R. Monte Carlo Analysis of the Dose Contributions from Primary and Secondary Particles in Light-ion therapy. 53rd Annual Conference of the Particle Therapy Co-Operative Group, Shanghai, China, 2014.
- Bronk L, Guan F, Kerr M, Titt U, Mirkovic D, Dinh J, Lin S, Mohan R, Grosshans D. High-throughput Mapping of Proton Biologic Effect. 23rd International Conference on the Application of Accelerators in Research and Industry, San Antonio, TX, 2014.
- Peeler C, Taleei R, Guan F, Bronk L, Grosshans D, Mirkovic D, Titt U, Mohan R. Radiobiological Modeling of High-Throughput Proton Irradiation Cell Survival Experiments. 23rd International Conference on the Application of Accelerators in Research and Industry, San Antonio, TX, 2014.
- Mirkovic D, Titt U, Randeniya S, Guan F, Peeler C, Ge S, Mohan R. Particle Therapy Research Group at MDACC. Horizons 2013: Connecting AAPM & PS-OCs, Bethesda, MD, 2013.
- Guan F, Mohan R, Dinh J, Kerr M, Perles L, Mirkovic D, Titt U, Zhu XR, Gillin M, Meyn R, Lin S, Grosshans D. Experimental Design and Preliminary Results for High-Resolution and High-Throughput In-Vitro Measurements of Proton RBE. Med Phys, 2013.
- Guan F, Titt U, Bangert M, Mohan R. In Search of the Optimum Ion for Radiotherapy. Med Phys, 2013.
- Titt U, Guan F, Mirkovic D, Mohan R. On the Out-Of-Field-Doses Caused by Secondary Particles From Light Ion Beams in Charged Particle Therapy. Med Phys, 2013.
- Kerr M, Dhanesar S, Guan F, Taylor M, Zhu X, Gillin M, Amos R, Poenisch F, Sahoo N. Relative Proton Stopping Power Ratio Database for Common Dosimetry Phantom Materials. Med Phys, 2013.
- Mohan R, Guan F, Dinh J, Kerr M, Mirkovic D, Titt U, Zhu R, Gillin M, Meyn R, Lin S, Grosshans D. Experimental Design and Preliminary Results for High-Resolution and High-Throughput In-Vitro Measurements of Proton RBE. 52nd Annual Conference of the Particle Therapy Co-Operative Group, Essen, Germany, 2013.
- Guan F, Poston J and Braby L. Joint Application of Perl Scripts and MCNPX in Solving the Dynamic-Geometry Related Problems in Proton Beam Radiotherapy. The Joint International Conference of the 7th Supercomputing in Nuclear Application and the 3rd Monte Carlo (SNA+MC 2010), Tokyo, Japan, 2010.
- Guan F, Poston J and Braby L. Design and Simulation of a Passive-Scattering Nozzle in Proton Beam Radiotherapy. 55th Annual Meeting of the Health Physics Society, Salt Lake City, UT, 2010.
Book Chapters
- Mohan R, Titt U, Guan F. Chapter 2, Particle Therapy in the Third Millennium: Current Status and Future Outlook. In: Particle Radiotherapy—Emerging Technology for Treatment of Cancer. 1. Springer: India, 7-19, 2016.
Books (edited and written)
- Guan F. Design and Simulation of a Passive Scattering Nozzle in Proton Therapy. 1. LAP Lambert Academic Publishing: Germany, 124, 2011.
Grant & Contract Support
| Title: | Characterizing the biologic response of therapeutic protons at the cellular and DNA level in terms of their physical interactions |
| Funding Source: | AAPM |
| Role: | Principal Investigator |
| Title: | Linking the physical interactions and biologic response to therapeutic protons at the cellular and DNA level |
| Funding Source: | CROR Seed Funding Program, UT MD Anderson Cancer Center |
| Role: | Principal Investigator |
| Title: | Advancing Linear Energy Transfer Models for Biologically Optimized Proton Therapy |
| Funding Source: | IRG Basic Award, UT MD Anderson Cancer Center |
| Role: | Co-Principal Investigator |
| Title: | Improving the Clinical Effectiveness and Understanding of the Biophysical Basis of Proton Therapy: Project 4 - Improving outcomes by optimally exploiting physical and biological characteristics of protons |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Mapping Proton RBE Variability Using Automated Biology and Monte Carlo Techniques |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | The Future Particle Therapy: Physics and Biology of Light Ions |
| Funding Source: | SINF, Sister Institution Network Fund |
| Role: | Co-Investigator |
| Title: | Improving Survival Outcomes Harnessing the Biological, Immunologic and Physical Properties of Heavy Charged Particles |
| Funding Source: | University of Texas MD Anderson Cancer Center |
| Role: | Co-Investigator |
| Title: | Interpreting DNA damage as a function of particle track structure for intensity-modulated proton therapy |
| Funding Source: | IRG Basic Award, UT MD Anderson Cancer Center |
| Role: | Principal Investigator |
| Title: | Ex Vivo Modeling of the Neurotoxicity of Cancer Treatments |
| Funding Source: | IRG Basic Award, UT MD Anderson Cancer Center |
| Role: | Collaborator |
| Title: | Enhancing the Biological Effects of IMPT using a Novel Beam Delivery Strategy |
| Funding Source: | Radiation Oncology Division Boot Walk Seed Grant |
| Role: | Co-Principal Investigator |
| Title: | Pre-clinical studies of heavy ions and protons |
| Funding Source: | Radiation Oncology Strategic Initiatives (ROSI) |
| Role: | Co-Investigator |
| Title: | Imaging and Radiation Oncology Core (IROC) Group |
| Funding Source: | American College of Radiology |
| Role: | Co-Investigator |
| Title: | Accounting for and harnessing RBE variability in proton therapy |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Title: | Impacting cancer outcomes through enhanced linear energy transfer proton therapy (ELPT) Project 1. Determine if ELPT increases immunogenic cell death and the adaptive immune response, thereby enhancing the systemic effects of radiation therapy |
| Funding Source: | MD Anderson ROSI Shark Tank Award |
| Role: | Co-Principal Investigator |
| Title: | Advancing microdosimetry and DNA damage-based RBE models for proton therapy |
| Funding Source: | Radiation Oncology Strategic Initiatives (ROSI) Boot Walk Award |
| Role: | Principal Investigator |
| Title: | Clinical Potential of a Monte Carlo-Based Biological Dose Optimization System for Intensity-Modulated Particle Therapy |
| Funding Source: | IRG Basic Award, UT MD Anderson Cancer Center |
| Role: | Principal Investigator |