Fada Guan, Ph.D., DABR
Department of Radiation Physics, Division of Radiation Oncology
Present Title & Affiliation
Primary Appointment
Assistant Professor (Clinical Faculty Appointment), Department of Radiation Physics - Patient Care, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Associate Faculty Member, The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, Texas
Education & Training
Degree-Granting Education
| 2012 | Texas A&M University, College Station, Texas, US, Nuclear Engineering, Advisor: John W. Poston, Sr., Ph.D, Ph.D |
| 2009 | Texas A&M University, College Station, Texas, US, Health Physics, Advisor: John W. Poston, Sr., Ph.D, M.S |
| 2005 | Tsinghua University, Beijing, CN, Nuclear Engineering, Advisors: Prof. Huaibi Chen & Prof. Quanfeng Li, B.E |
Licenses & Certifications
| 2024 | American Board of Radiology, Board Certification in Therapeutic Medical Physics |
Experience & Service
Faculty Academic Appointments
Assistant Professor (Clinician-Educator-Scholar track), Department of Therapeutic Radiology, Yale University School of Medicine/Yale New Haven Hospital, New Haven, Connecticut, 2023 - 2024
Associate Faculty Member, The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, Texas, 2016 - 2021
Assistant Professor (Research Faculty Appointment), Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2016 - 2021
Institutional Committee Activities
Chair, Microdosimetry Working Group, Division of Radiation Oncology, 2025 - Present
Member, Medical Physics Seminar Organizing Committee, 2025 - Present
Member, CNS/Pediatric Physics Hardware Workgroup, 2025 - Present
Member, Particle Therapy Working Group of Division of Radiation Oncology, 2024 - Present
Member, CNS/Pediatric Physics Research Committee, 2024 - Present
Member, Particle Therapy Subcommittee (PTSC) of American Association of Physicists in Medicine, 2024 - Present
Member, Therapeutic Medical Physics Residency Admission Committee, 2023 - 2024
Member, Therapeutic Medical Physics Residency Steering Committee, 2023 - 2024
Member, Joint Working Group for Research Seed Funding Initiative (JWGRSF) of American Association of Physicists in Medicine, 2023 - Present
Member, Electromagnetic Physics Working Group of Geant4 International Collaboration, 2023 - Present
Member, PET-linac RefleXion Commissioning Workgroup, 2022 - 2023
Member, Linac TrueBeam Commissioning Workgroup, 2021 - 2021
Member, Aaron Blanchard Award Committee in Medical Physics Program, 2018
Honors & Awards
| 2025 | Travel Award to Particle Therapy Cooperative Group (PTCOG) 63rd Annual Meeting, American Association of Physicists in Medicine |
| 2024 | Cover Article, Precision Radiation Oncology: Volume 8, Issue 4, December 2024 |
| 2023 | AWS Cloud Credits for Research Program at Yale, Yale University |
| 2019 | Early Career Investigator Travel Award, Radiation Research Society |
| 2018 | Outstanding Reviewer Awards 2017 for Biomedical Physics & Engineering Express, IOP Publishing |
| 2018 | Early Career Investigator Travel Award, Radiation Research Society |
| 2017 | Outstanding Reviewer Awards 2016 for Physics in Medicine and Biology, IOP Publishing |
| 2016 | Highlights of 2015 (with Geng et al.), Journal of Radiological Protection |
| 2016 - 2017 | Research Seed Funding Initiative Award, American Association of Physicist in Medicine |
| 2015 | AMGEN Award in Basic Science Research, Finalist, Trainee Research Day, UT MD Anderson Cancer Center |
| 2015 | Radiation Physics Feature Article, Medical Physics Program, UT MD Anderson Cancer Center |
| 2015 | Trainee Award, Trainee Recognition Programs, UT MD Anderson Cancer Center |
| 2014 | Scholars-in-Training Travel Award, Radiation Research Society |
| 2014 | Trainee Award, Trainee Recognition Programs, UT MD Anderson Cancer Center |
| 2010 | First Place, Student Paper Competition, South Texas Chapter, Health Physics Society |
| 2010 | First Place, Nuclear Science Session of Student Research Week, Texas A&M University |
| 2010 - 2011 | Student Education Grant, South Texas Chapter, Health Physics Society |
Professional Memberships
Selected Presentations & Talks
Local Presentations
- 2025. Physical Parameters in Particle Therapy: Bridging Physics and Biology. Invited. Houston, Texas, US.
- 2025. Interpreting the biological effects of particle therapy as a function of linear energy transfer (LET) and microdosimetric lineal energy spectrum. Invited. Radiation Oncology Proton, Physics, Planning and Outcomes. Houston, Texas, US.
- 2019. Protons and Beyond-The Promise of Particle Therapy. Invited. Houston, Texas, US.
Regional Presentations
- 2018. Review of Physical and Biological Factors Affecting the Relative Biological Effectiveness of Proton Beams. Conference. SWAAPM Spring Meeting. Houston, US.
National Presentations
- 2025. Interpreting the biological effects of particle therapy as a function of linear energy transfer (LET) and microdosimetric lineal energy spectrum. Invited. Medical Physics Seminar series hosted by the Department of Radiation Oncology. Kansas City, Kansas, US.
- 2024. Radiopharmaceutical Therapy: Renaissance of Nuclear Medicine. Invited. Therapeutic Radiology Grand Rounds. New Haven, Connecticut, US.
- 2021. Spatial Mapping of the Biological Effects of Proton Beam Radiotherapy. Invited. Rensselaer Polytechnic Institute. Troy, NY, US.
- 2019. The biological effects of intensity-modulated proton therapy: a comparison between high-throughput experimental results and model predictions. Conference. 65th Annual Meeting of Radiation Research Society. San Diego, CA, US.
- 2019. Comparing the Microdosimetric Kinetic Model-Predicted Proton RBE Values using Constant and Variable Quadratic Beta Coefficients. Conference. 61st Annual Meeting of American Society for Radiation Oncology. Chicago, IL, US.
- 2018. Development of easy-to-implement biological dose optimization algorithms for particle radiobiology. Conference. 64th Annual Meeting of Radiation Research Society. Chicago, IL, US.
- 2018. Repair-Misrepair-Fixation (RMF) Model-Based Biological Dose Optimization for Scanned Ion Beams. Conference. 60th AAPM Annual Meeting & Exhibition. Nashville, TN, US.
- 2017. The correlation of biological effects and physical parameters in proton therapy. Conference. CPRIT's Innovations in Cancer Prevention and Research Conference V. Austin, TX, US.
- 2017. Investigation of the Spatial Ionization Density Dependence of the DNA Damage in a Lung Cancer Cell Line with Proton Irradiations. Conference. 59th AAPM Annual Meeting & Exhibition. Denver, CO, US.
- 2016. Investigation of LET Spectral Dependence of the Biological Effects of Therapeutic Protons. Conference. 58th AAPM Annual Meeting & Exhibition. Washington, DC, US.
- 2015. Quantifying the Biological Effects of Therapeutic Protons by LET Spectrum Analysis. Conference. 57th AAPM Annual Meeting & Exhibition. Anaheim, CA, US.
- 2014. A Novel Technique for High-throughput, High-precision Spatial Mapping of the Biologic Effectiveness of Therapeutic Proton Beam. Conference. 60th Annual Meeting of Radiation Research Society. Las Vegas, NV, US.
- 2014. A Novel Monte Carlo Algorithm for Solving the True Coincident Counting Issues in Monte Carlo Simulations for Gamma Spectroscopy. Conference. 59th Annual Meeting of the Health Physics Society. Baltimore, MD, US.
- 2014. The Effect of Particle Tracking Step Size Limit on Monte Carlo-Computed LET Spectrum of Therapeutic Proton Beams. Conference. 56th AAPM Annual Meeting & Exhibition. Austin, TX, US.
- 2013. In Search of the Optimum Ion for Radiotherapy. Conference. 55th AAPM Annual Meeting & Exhibition. Indianapolis, IN, US.
- 2013. Experimental Design and Preliminary Results for High-Resolution and High-Throughput In-Vitro Measurements of Proton RBE. Conference. 55th AAPM Annual Meeting & Exhibition. Indianapolis, IN, US.
- 2010. Design and Simulation of a Passive-Scattering Nozzle in Proton Beam Radiotherapy. Conference. 55th Annual Meeting of the Health Physics Society. Salt Lake City, UT, US.
International Presentations
- 2024. Interpreting the biological effects of particle therapy as a function of linear energy transfer (LET) and microdosimetric lineal energy spectrum. Invited. 2nd Microdosimetry Workshop, Austria or online. Wiener Neustadt, AT.
- 2023. Protons and Beyond—The Promise of Particle Therapy. Invited. Huangshan Medical Physics Forum. Huangshan, CN.
- 2016. Innovations in Spatial Mapping of the RBE of Scanned Particle Beams. Invited. 24th International Conference On The Application of Accelerators In Research And Industry. Fort Worth, US.
- 2015. Spatial Mapping of the Biological Effectiveness of Scanned Proton Beams. Invited. Geant4-DNA 2015 Collaboration Meeting. Toulouse, FR.
Grant & Contract Support
| Date: | 2025 - 2026 |
| Title: | FLASH proton therapy: an innovative ultra-fast and ultra-sharp scalpel for radiosurgery |
| Funding Source: | MD Anderson |
| Role: | PI |
| ID: | 2025-00064784-Y1 |
| Date: | 2021 - 2026 |
| Title: | Integrating patient-specific clinical and biological factors towards individualizing utilization of proton and photon radiation therapy, Project 1: Understanding normal tissue toxicity to identify patients most likely to benefit from proton therapy |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2021 - 2026 |
| Title: | Integrating patient-specific clinical and biological factors towards individualizing utilization of proton and photon radiation therapy, Project 2: Radiation-Induced Lymphopenia: Understanding, Predictive Modeling and Developing Photon and Proton-Based Mitigation Strategies |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2021 - 2026 |
| Title: | Characterization of the cellular mechanisms of radiation induced brain necrosis for clinical intervention |
| Funding Source: | NIH/NCI |
| Role: | Other Significant Contributor |
| Date: | 2021 - 2022 |
| Title: | Targeting the Tumor Microenvironment to Enhance Immunogenic Cell Death Induced by High-LET Proton Radiation Therapy for Pancreatic Cancer Treatment |
| Funding Source: | Radiation Oncology Strategic Initiatives (ROSI) Immunotherapy Award |
| Role: | Co-PI |
| Date: | 2021 - 2022 |
| Title: | Translating FLASH-RT to Improve Outcomes in Pancreatic Cancer |
| Funding Source: | Radiation Oncology Strategic Initiatives (ROSI) Shark Tank Award |
| Role: | Co-I |
| Date: | 2020 - 2025 |
| Title: | Determining the optimal ion and fractionation scheme for the treatment of GBM in a comprehensive human organoid model |
| Funding Source: | NIH/NCI |
| Role: | Other Significant Contributor |
| Date: | 2020 - 2023 |
| Title: | Use of Microbial Based Countermeasures to Mitigate Radiation Induced Intestinal Damage |
| Funding Source: | Baylor College of Medicine/NASA TRISH |
| Role: | Co-I |
| Date: | 2020 - 2023 |
| Title: | Counteracting space radiation by targeting neurogenesis in a human brain organoid model |
| Funding Source: | Baylor College of Medicine/NASA TRISH |
| Role: | Co-I |
| Date: | 2020 - 2023 |
| Title: | TOF-PET for Proton Therapy (TPPT): In-beam Time-of-Flight (TOF) Positron Emission Tomography (PET) for proton radiation therapy |
| Funding Source: | Portuguese Science and Technology Foundation |
| Role: | Co-I |
| Date: | 2020 - 2021 |
| Title: | Clinical Potential of a Monte Carlo-Based Biological Dose Optimization System for Intensity-Modulated Particle Therapy |
| Funding Source: | IRG Basic Award, UT MD Anderson Cancer Center |
| Role: | PI |
| Date: | 2019 - 2022 |
| Title: | CrNR Alliance Funding |
| Funding Source: | CrNR Alliance Funding |
| Role: | Co-I |
| Date: | 2019 - 2021 |
| Title: | Advancing microdosimetry and DNA damage-based RBE models for proton therapy |
| Funding Source: | Radiation Oncology Strategic Initiatives (ROSI) Boot Walk Award |
| Role: | PI |
| Date: | 2019 - 2021 |
| Title: | Imaging and Radiation Oncology Core (IROC) Group |
| Funding Source: | American College of Radiology |
| Role: | Co-I |
| ID: | 1U24CA180803-07-IROC |
| Date: | 2018 - 2021 |
| Title: | Accounting for and harnessing RBE variability in proton therapy |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| Date: | 2018 - 2020 |
| Title: | Impacting cancer outcomes through enhanced linear energy transfer proton therapy (ELPT) Project 1. Determine if ELPT increases immunogenic cell death and the adaptive immune response, thereby enhancing the systemic effects of radiation therapy |
| Funding Source: | MD Anderson ROSI Shark Tank Award |
| Role: | Co-PI |
| Date: | 2018 - 2019 |
| Title: | Enhancing the Biological Effects of IMPT using a Novel Beam Delivery Strategy |
| Funding Source: | Radiation Oncology Division Boot Walk Seed Grant |
| Role: | Co-PI |
| Date: | 2017 - 2020 |
| Title: | Pre-clinical studies of heavy ions and protons |
| Funding Source: | Radiation Oncology Strategic Initiatives (ROSI) |
| Role: | Co-I |
| ID: | RCTS 55323 |
| Date: | 2017 - 2019 |
| Title: | Interpreting DNA damage as a function of particle track structure for intensity-modulated proton therapy |
| Funding Source: | IRG Basic Award, UT MD Anderson Cancer Center |
| Role: | PI |
| Date: | 2017 - 2019 |
| Title: | Ex Vivo Modeling of the Neurotoxicity of Cancer Treatments |
| Funding Source: | IRG Basic Award, UT MD Anderson Cancer Center |
| Role: | Collaborator |
| Date: | 2016 - 2018 |
| Title: | Improving Survival Outcomes Harnessing the Biological, Immunologic and Physical Properties of Heavy Charged Particles |
| Funding Source: | University of Texas MD Anderson Cancer Center |
| Role: | Co-I |
| ID: | 52987 |
| Date: | 2016 - 2017 |
| Title: | Characterizing the biologic response of therapeutic protons at the cellular and DNA level in terms of their physical interactions |
| Funding Source: | AAPM |
| Role: | PI |
| Date: | 2016 - 2017 |
| Title: | Linking the physical interactions and biologic response to therapeutic protons at the cellular and DNA level |
| Funding Source: | CROR Seed Funding Program, UT MD Anderson Cancer Center |
| Role: | PI |
| Date: | 2015 - 2017 |
| Title: | Advancing Linear Energy Transfer Models for Biologically Optimized Proton Therapy |
| Funding Source: | IRG Basic Award, UT MD Anderson Cancer Center |
| Role: | Co-PI |
| Date: | 2014 - 2019 |
| Title: | Improving the Clinical Effectiveness and Understanding of the Biophysical Basis of Proton Therapy: Project 4 - Improving outcomes by optimally exploiting physical and biological characteristics of protons |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 5U19CA021239 |
| Date: | 2014 - 2017 |
| Title: | Mapping Proton RBE Variability Using Automated Biology and Monte Carlo Techniques |
| Funding Source: | NIH/NCI |
| Role: | Co-I |
| ID: | 1R21CA187484-01 |
| Date: | 2014 - 2019 |
| Title: | Imaging and Radiation Oncology Core (IROC) Group |
| Funding Source: | American College of Radiology |
| Role: | Co-I |
| ID: | CA180803 |
| Date: | 2013 - 2016 |
| Title: | The Future Particle Therapy: Physics and Biology of Light Ions |
| Funding Source: | SINF, Sister Institution Network Fund |
| Role: | Co-I |
Selected Publications
Peer-Reviewed Articles
- Hartzell S, Taddei PJ, Guan F, Mirandola A, Taylor P, Ciocca M, Magro G, Peterson CB, Kry S. Microdosimetric evaluation of a clinical carbon ion beam using a tissue-equivalent proportional counter. Physics in Medicine and Biology. e-Pub 2025.
- Wang Y, Jian W, Yuan Z, Guan F. Deep learning with attention modules and residual transformations improves hepatocellular carcinoma (HCC) differentiation using multiphase CT. Precis Radiat Oncol, 2025. e-Pub 2025.
- Zhong W, Chen Z, Lee M, Guan F, Chen H, Han DY. Measurements of Small Field Output Correction Factors on a RefleXion Treatment Machine. Precis Radiat Oncol, 2025. e-Pub 2025.
- Wang Y, Yang X, Xiao H, Guan F, Aneja S. Hypofractionated radiotherapy (RT) combined with dihydroartemisinin (DHA): No synergistic effect observed in a preliminary animal study. Precis Radiat Oncol, 2025. e-Pub 2025.
- Wang, Y, Yang, X, Xiao, H, Guan, F, Aneja, S. Hypofractionated radiotherapy (RT) combined with dihydroartemisinin (DHA). Precis Radiat Oncol 9(1):54-60, 2025. e-Pub 2025.
- Zhong, W, Chen, Z, Lee, MY, Guan, F, Chen, H, Han, DY. Measurements of Small Field Output Correction Factors on a RefleXion Treatment Machine. Precis Radiat Oncol 9(1):35-42, 2025. e-Pub 2025.
- Wang, Y, Jian, W, Yuan, Z, Guan, F, Carlson, DJ. Deep learning with attention modules and residual transformations improves hepatocellular carcinoma (HCC) differentiation using multiphase CT. Precis Radiat Oncol 9(1):13-22, 2025. e-Pub 2025.
- Draeger E, Guan F, Lee M, Han DY, Donahue W, Chen Z. Clinical use of Gafchromic EBT4 film for in vivo dosimetry for total body irradiation. J Appl Clin Med Phys 26(3):e14574, 2025. e-Pub 2025. PMID: 39611814.
- Hartzell S, Guan F, Magro G, Taylor P, Taddei PJ, Christine B, Peterson, Kry S. Contribution of Nuclear Fragmentation to Dose and RBE in Carbon-Ion Radiotherapy. Radiat Res 203(2):96-106, 2025. e-Pub 2025. PMID: 39862066.
- Bordieri G, Missiaggia M, Cartechini G, Battestini M, Bronk L, Guan F, Grosshans DR, Rai P, Scifoni E, Tessa CL, Lattanzi G, Cordoni FG. Validation of the generalized stochastic microdosimetric model (GSM 2 ) over a broad range of LET and particle beam type. Phys Med Biol 70(1), 2025. e-Pub 2025. PMID: 39662041.
- Guan F, Jiang D, Wang X, Yang M, Iga K, Li Y, Bronk LF, Bronk JK, Wang L, Guo Y, Sahoo N, Grosshans DR, Koong AC, Zhu XR, Mohan R. Mimicking large spot-scanning radiation fields for proton FLASH preclinical studies with a robotic motion platform. Precis Radiat Oncol 8(4):168-181, 2024. e-Pub 2024. PMID: 40337456.
- Wang Y, Guan F, Ouyang F, Yuan H, Su M, Ding X. Heart ultrasound and biomechanical evaluation of radiation-induced heart toxicity using transthoracic echocardiogram (TTE) and dynamic mechanical analysis (DMA). Precis Radiat Oncol 8(4):200-208, 2024. e-Pub 2024. PMID: 40337453.
- Guan F, Donahue W, Biggs S, Jennings M, Draeger E, Chen H, Wang Y, Nguyen N, Carlson DJ, Chen Z, Han DY. 3D gamma analysis between treatment plans for nominally beam-matched medical linear accelerators using PyMedPhys. Precis Radiat Oncol 8(4):191-199, 2024. e-Pub 2024. PMID: 40337454.
- Wang Y, Guan F, Wang S, Jian W, Khan M. Radiation induced liver injury (RILI) evaluation using longitudinal computed tomography (CT) in image-guided precision murine radiotherapy. Precis Radiat Oncol 8(4):182-190, 2024. e-Pub 2024. PMID: 40337459.
- Guan F, Bronk LF, Kerr M, Li Y, Braby LA, Sobieski M, Wang X, Zhang X, Stephan C, Grosshans DR, Mohan R. Interpreting the biological effects of protons as a function of physical quantity: linear energy transfer or microdosimetric lineal energy spectrum?. Sci Rep 14(1):25181, 2024. e-Pub 2024. PMID: 39448656.
- Li M, Geng C, Han Y, Guan F, Liu Y, Shu D, Tang X. Incorporating boron distribution variations in microdosimetric kinetic model-based relative biological effectiveness calculations for boron neutron capture therapy. Radiat Prot Dosimetry 200(14):1319-1328, 2024. e-Pub 2024. PMID: 39010755.
- Sun X, Guan F, Yun Q, Jennings M, Biggs S, Wang Z, Wang W, Zhang T, Shi M, Zhao L. Impact of setup errors on the robustness of linac-based single-isocenter coplanar and non-coplanar VMAT plans for multiple brain metastases. J Appl Clin Med Phys 25(7):e14317, 2024. e-Pub 2024. PMID: 38439583.
- Song Y, Zhang Y, Wang H, Zhao M, Guan F, Li Z, Yue J. Case Report: MR-LINAC-guided adaptive radiotherapy for gastric cancer. Front Oncol 13, 2023. e-Pub 2023. PMID: 37746250.
- Guan, F, Chen, H, Draeger, E, Li, Y, Aydin, R, Tien, CJ, Chen, Z. Characterization of GafchromicTM EBT4 film with clinical kV/MV photons and MeV electrons. Precis Radiat Oncol 7(2):84-91, 2023. e-Pub 2023. PMID: 40337264.
- Ferrone KL, Willis CE, Guan F, Ma J, Peterson LE, Kry SF. Evaluating bone marrow dosimetry with the addition of bone marrow structures to the medical internal radiation dose phantom. Prec Radiat Oncol 7(1):27-35, 2023. e-Pub 2023.
- Chen M, Cao W, Yepes P, Guan F, Poenisch F, Xu C, Chen J, Li Y, Vazquez I, Yang M, Zhu XR, Zhang X. Impact of dose calculation accuracy on inverse linear energy transfer optimization for intensity-modulated proton therapy. Prec Radiat Oncol 7(1):36-44, 2023. e-Pub 2023. PMID: 40336617.
- Guan, F, Asai, M, Bartkoski, DA, Kleckner, M, Harel, Z, Salehpour, M. Adding the X-ray Bragg reflection physical process in crystal to the Geant4 Monte Carlo simulation toolkit, part I. Precision Radiation Oncology 7(1):59-66, 2023. e-Pub 2023. PMID: 40336621.
- Ferrone, KL, Willis, CE, Guan, F, Ma, J, Peterson, L, Kry, SF. Evaluating bone marrow dosimetry with the addition of bone marrow structures to the medical internal radiation dose phantom. Precision Radiation Oncology 7(1):27-35, 2023. e-Pub 2023. PMID: 40336618.
- Chen M, Cao W, Yepes P, Guan F, Poenisch F, Xu C, Chen J, Yupeng L, Zhu X, Zhang X. Impact of dose calculation accuracy on inverse linear energy transfer optimization for intensity-modulated proton therapy. Prec Radiat Oncol 7(1):36-44, 2023. e-Pub 2023.
- Guan F, Wang X, Yang M, Draeger E, Han D, Iga K, Guo F, Perles LA, Li Y, Sahoo N, Mohan R, Chen Z. Dosimetric response of Gafchromic™ EBT-XD film to therapeutic protons. Precision Radiation Oncology 7(1):15-26, 2023. e-Pub 2023. PMID: 37868341.
- Bokhari RS, Beheshti A, Blutt SE, Bowles DE, Brenner D, Britton RA, Bronk LF, Cao X, Chatterjee A, Clay DE, Courtney C, Fox DT, Gaber MW, Gerecht-Nir S, Grabham P, Grosshans DR, Guan F, Jezuit EA, Kirsch DG, Liu Z, Maletić-Savatić M, Miller KM, Montague RA, Nagpal P, Osenberg S, Parkitny L, Pierce NA, Porada C, Rosenberg SM, Sargunas P, Sharma S, Spangler J, Tavakol DN, Thomas D, Vunjak-Novakovic G, Wang C, Whitcomb L, Young DW, Donoviel D. Looking on the horizon; potential and unique approaches to developing radiation countermeasures for deep space travel. Life Sciences in Space Research 35:105-112, 2022. e-Pub 2022. PMID: 36336356.
- McNerlin C, Guan F, Bronk LF, Lei K, Grosshans DR, Young DW, Gaber MW, Maletić-Savatić M. Targeting hippocampal neurogenesis to protect astronauts’ cognition and mood from decline due to space radiation effects. Life Sci Space Res (Amst) 35:170-179, 2022. e-Pub 2022. PMID: 36336363.
- Wang, Q, Titt, U, Mohan, R, Guan, F, Zhao, Y, Yang, M, Yepes, P. Optimization of FLASH proton beams using a track-repeating algorithm. Medical physics 49(10):6684-6698, 2022. e-Pub 2022. PMID: 35900902.
- Yang, M, Wang, X, Guan, F, Titt, U, Iga, K, Jiang, D, Takaoka, T, Tootake, S, Katayose, T, Umezawa, M, Schueler, E, Frank, SJ, Lin, SH, Sahoo, N, Koong, A, Mohan, R, Zhu, XR. Adaptation and dosimetric commissioning of a synchrotron-based proton beamline for FLASH experiments. Phys Med Biol 67(16), 2022. e-Pub 2022. PMID: 35853442.
- Hartzell, S, Guan, F, Taylor, PA, Peterson, CB, Taddei, PJ, Kry, SF. Uncertainty in tissue equivalent proportional counter assessments of microdosimetry and RBE estimates in carbon radiotherapy. Phys Med Biol 66(15), 2021. e-Pub 2021. PMID: 34252894.
- Ferrone, KL, Guan, F, Ma, J, Peterson, L, Willis, CE, Kry, SF. Reducing space radiation cancer risk with magnetic shielding. Advances in Space Research 68(1):153-160, 2021. e-Pub 2021.
- Lopez B, Guan F, Rauch G, Kappadath C. Monte Carlo simulation of pixelated CZT detector with Geant4: Validation of clinical molecular breast imaging system. Phys Med Biol 66(12), 2021. e-Pub 2021. PMID: 34038878.
- Qi J, Geng C, Tang X, Tian F, Han Y, Liu H, Liu Y, Bortolussi S, Guan F. Effect of spatial distribution of boron and oxygen concentration on DNA damage induced from boron neutron capture therapy using Monte Carlo simulations. International Journal of Radiation Biology, 2021. e-Pub 2021.
- Ferrone K, Guan F, Ma J, Peterson L, Willis C, Kry S. Reducing space radiation cancer risk with magnetic shielding. Advances in Space Research, 2021. e-Pub 2021.
- Qi J, Geng C, Tang X, Tian F, Han, Y, Liu H, Liu Y, Bortolussi S, Guan F. Effect of spatial distribution of boron and oxygen concentration on DNA damage induced from boron neutron capture therapy using Monte Carlo simulations. International journal of radiation biology 97(7):986-996, 2021. e-Pub 2021. PMID: 33970761.
- Bronk L, Guan F, Patel D, Ma D, Kroger B, Wang X, Tran K, Yiu J, Stephan C, Debus J, Abdollahi A, Jäkel O, Mohan R, Titt U, Grosshans DR. Mapping the Relative Biological Effectiveness of Proton, Helium and Carbon Ions with High-Throughput Techniques. Cancers (Basel) 12(12), 2020. e-Pub 2020. PMID: 33291477.
- Ma D, Bronk L, Kerr M, Sobieski M, Chen M, Geng C, Yiu J, Wang X, Sahoo N, Cao W, Zhang X, Stephan C, Mohan R, Grosshans DR, Guan F. Author Correction: Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns. Sci Rep 10(1):19101, 2020. e-Pub 2020. PMID: 33127998.
- Shao W, Tang X, Geng C, Shu D, Gong C, Zhang X, Guan F. Investigation of irregular radiation field based proton therapy using conformal dose layer stacking method. Int J Rad Res 18(2), 2020. e-Pub 2020.
- Ma D, Bronk L, Kerr M, Sobieski M, Chen M, Geng C, Yiu J, Wang X, Sahoo N, Cao W, Zhang X, Stephan C, Mohan R, Grosshans DR, Guan F. Exploring the Advantages of Intensity-modulated Proton Therapy: Experimental Validation of Biological Effects using Two Different Beam Intensity-modulation Patterns. Sci Rep 10(1):3199, 2020. e-Pub 2020. PMID: 32081928.
- Tang D, Liang Z, Guan F, Yang Z. Dosimetric and Radiobiological Comparison of Five Techniques for Postmastectomy Radiotherapy with Simultaneous Integrated Boost. Biomed Res Int 2020:9097352, 2020. e-Pub 2020. PMID: 32775448.
- Darne CD, Alsanea F, Robertson DG, Guan F, Pan T, Grosshans D, Beddar S. A proton imaging system using a volumetric liquid scintillator: a preliminary study. Biomed Phys Eng Express 5(4), 2019. e-Pub 2019. PMID: 32194988.
- Newpower M, Patel D, Bronk L, Guan F, Chaudhary P, McMahon SJ, Prise KM, Schettino G, Grosshans DR, Mohan R. Using the Proton Energy Spectrum and Microdosimetry To Model Proton Relative Biological Effectiveness. Int J Radiat Oncol Biol Phys 104(2):316-324, 2019. e-Pub 2019. PMID: 30731186.
- Geng C, Ai Y, Tang X, Shu D, Gong C, Guan F. A Monte Carlo study of pinhole collimated Cerenkov luminescence imaging integrated with radionuclide treatment. Australas Phys Eng Sci Med 42(2):481-487, 2019. e-Pub 2019. PMID: 30830649.
- Yang P, Xu T, Gomez DR, Deng W, Wei X, Elhalawani H, Jin H, Guan F, Mirkovic D, Xu Y, Mohan R, Liao Z. Patterns of Local-Regional Failure after Intensity-Modulated Radiation Therapy or Passive Scattering Proton Therapy with Concurrent Chemotherapy for Non-Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys 103(1):123-131, 2019. e-Pub 2019. PMID: 30165127.
- Ge S, Wang X, Liao Z, Zhang L, Sahoo N, Yang J, Guan F, Mohan R. Potential for Improvements in Robustness and Optimality of Intensity-Modulated Proton Therapy for Lung Cancer with 4-Dimensional Robust Optimization. Cancers (Basel) 11(1), 2019. e-Pub 2019. PMID: 30609652.
- Guan F, Geng C, Carlson DJ, Ma DH, Bronk L, Gates D, Wang X, Kry SF, Grosshans D, Mohan R. A Mechanistic Relative Biological Effectiveness Model-based Biological Dose Optimization for Charged Particle Radiobiology Studies. Phys Med Biol 64(1):015008, 2018. e-Pub 2018. PMID: 30523805.
- Jiang B, Wang X, Zhang Y, Guan F, Li Y, Wang X, Zhu RX, Zhang X. Power-law relationship in the long-tailed sections of proton dose distributions. Sci Rep 8(1):10413, 2018. e-Pub 2018. PMID: 29991734.
- Geng C, Gates D, Bronk L, Ma D, Guan F. Physical Parameter Optimization Scheme for Radiobiological Studies of Charged Particle Therapy. Phys Med 51:13-21, 2018. e-Pub 2018. PMID: 30278981.
- Guan F, Peeler C, Bronk L, Geng C, Taleei R, Randeniya S, Ge S, Mirkovic D, Grosshans D, Mohan R, Titt U. Erratum: "Analysis of the track- and dose-averaged LET and LET spectra in proton therapy using the geant4 Monte Carlo code" [Med. Phys. 42 (11), page range 6234-6247(2015)]. Med Phys 45(3):1302, 2018. e-Pub 2018. PMID: 29527697.
- Taleei R, Guan F, Peeler C, Bronk L, Patel D, Mirkovic D, Grosshans DR, Mohan R, Titt U. Erratum: "Monte Carlo simulations of 3 He ion physical characteristics in a water phantom and evaluation of radiobiological effectiveness" [Med. Phys. 43 (2), page range 761-776(2016)]. Med Phys 45(3):1301, 2018. e-Pub 2018. PMID: 29527699.
- Shao W, Tang X, Bai Y, Shu D, Geng C, Gong C, Guan F. Investigation of the dose perturbation effect for therapeutic beams with the presence of a 1.5 T transverse magnetic field in magnetic resonance imaging-guided radiotherapy. J Cancer Res Ther 14(1):184-195, 2018. e-Pub 2018. PMID: 29516984.
- Guan F, Geng C, Ma D, Bronk L, Kerr M, Li Y, Gates D, Kroger B, Sahoo N, Titt U, Grosshans D, Mohan R. RBE model-based biological dose optimization for proton radiobiology studies. Int J Part Ther 5(1):160-171, 2018. e-Pub 2018. PMID: 30338268.
- Patel D, Bronk L, Guan F, Peeler CR, Brons S, Dokic I, Abdollahi A, Rittmüller C, Jäkel O, Grosshans D, Mohan R, Titt U. Optimization of Monte Carlo particle transport parameters and validation of a novel high throughput experimental setup to measure the biological effects of particle beams. Med Phys 44(11):6061–6073, 2017. e-Pub 2017. PMID: 28880368.
- Zhang Y, Kerr M, Guan F, Hartman J, Jiang B, Sahoo N, Zhu X, Gillin M, Qian W, Zhang X. Dose Calculation for Spot Scanning Proton Therapy with the Application of a Range Shifter. Biomed. Phys. Eng. Express 3(3), 2017. e-Pub 2017.
- Shu D, Tang X, Guan F, Geng C, Yu H, Gong C, Zhang X, Chen D. Analysis of the Relationship between Neutron Dose and Cerenkov Photons under Neutron Irradiation through Monte Carlo Method. Radiation Measurements 93, 2016. e-Pub 2016.
- Yepes P, Guan F, Kerr M, Randeniya S, Li Y, Bronk L, Liu A, Mirkovic D, Sahoo N, Titt U, Anand A, Mohan R. Validation of a Track-Repeating Algorithm Versus Measurements in Water for Proton Scanning Beams. Biomedical Physics & Engineering Express 2(3), 2016. e-Pub 2016.
- Geng C, Tang X, Guan F, Johns J, Vasudevan L, Gong C, Shu D, Chen D. GEANT4 calculations of neutron dose in radiation protection using a homogeneous phantom and a Chinese hybrid male phantom. Radiat Prot Dosimetry 168(4):433-40, 2016. e-Pub 2016. PMID: 26156875.
- Taleei R, Guan F, Peeler C, Bronk L, Patel D, Mirkovic D, Grosshans DR, Mohan R, Titt U. Monte Carlo simulations of ³He ion physical characteristics in a water phantom and evaluation of radiobiological effectiveness. Med Phys 43(2):761-76, 2016. e-Pub 2016. PMID: 26843239.
- Geng C, Tang X, Gong C, Guan F, Johns J, Shu D, Chen D. A Monte Carlo-based radiation safety assessment for astronauts in an environment with confined magnetic field shielding. J Radiol Prot 35(4):777-88, 2015. e-Pub 2015. PMID: 26484984.
- Guan F, Peeler C, Bronk L, Geng C, Taleei R, Randeniya S, Ge S, Mirkovic D, Grosshans D, Mohan R, Titt U. Analysis of the track- and dose-averaged LET and LET spectra in proton therapy using the geant4 Monte Carlo code. Med Phys 42(11):6234-47, 2015. e-Pub 2015. PMID: 26520716.
- Geng C, Tang X, Qian W, Guan F, Johns J, Yu H, Gong C, Shu D, Chen D. Calculations of S values and effective dose for the radioiodine carrier and surrounding individuals based on Chinese hybrid reference phantoms using the Monte Carlo technique. J Radiol Prot 35(3):707-17, 2015. e-Pub 2015. PMID: 26344387.
- Guan F, Johns JM, Vasudevan L, Zhang G, Tang X, Poston JW, Braby LA. A novel algorithm for solving the true coincident counting issues in Monte Carlo simulations for radiation spectroscopy. Health Phys 108(6):574-9, 2015. e-Pub 2015. PMID: 25905518.
- Guan F, Bronk L, Titt U, Lin SH, Mirkovic D, Kerr MD, Zhu XR, Dinh J, Sobieski M, Stephan C, Peeler CR, Taleei R, Mohan R, Grosshans DR. Spatial mapping of the biologic effectiveness of scanned particle beams: towards biologically optimized particle therapy. Sci Rep 5:9850, 2015. e-Pub 2015. PMID: 25984967.
- You J, Zhao J, Wen X, Wu C, Huang Q, Guan F, Wu R, Liang D, Li C. Chemoradiation therapy using cyclopamine-loaded liquid-lipid nanoparticles and lutetium-177-labeled core-crosslinked polymeric micelles. J Control Release 202:40-8, 2015. e-Pub 2015. PMID: 25637565.
- Guan F, Ton P, Ge S, Zhao L. Anisotropic Diffusion Filtering for Ultrasound Speckle Reduction. Sci China Tech Sci 57(3):607-614, 2014. e-Pub 2014.
- Guan F, Poston J, Braby L. Joint Application of Perl Scripts and MCNPX in Solving the Dynamic-Geometry Related Problems in Proton Beam Radiotherapy. Progress in Nuclear Science and Technology 2:176-180, 2011. e-Pub 2011.
- Zhang J, Li Q, Chen H, Guo B, Guan F. Electron Beam Therapy Mode Analysis of Medical Linac by BEAM Code. Atomic Energy Science and Technology 43(7):667-672, 2009. e-Pub 2009.
Invited Articles
- Mairani A, Mein S, Blakely E, Debus J, Durante M, Ferrari A, Fuchs H, Georg D, Grosshans DR, Guan F, Haberer T, Harrabi S, Horst F, Inaniwa T, Karger CP, Mohan R, Paganetti H, Parodi K, Sala P, Schuy C, Tessonnier T, Titt U, Weber U. Roadmap: Helium Ion Therapy. Physics in medicine and biology 67(15), 2022. e-Pub 2022. PMID: 35395649.
- Mohan R, Peeler CR, Guan F, Bronk L, Cao W, Grosshans DR. Radiobiological Issues in Proton Therapy. Acta Oncol 56(11):1-7, 2017. e-Pub 2017. PMID: 28826292.
Review Articles
- Yang Z, Guan F, Bronk L, Zhao L. Multi-omics approaches for biomarker discovery in predicting the response of esophageal cancer to neoadjuvant therapy: A multidimensional perspective. Pharmacol Ther 254:108591, 2024. e-Pub 2024. PMID: 38286161.
- Ferrone K, Willis C, Guan F, Ma J, Peterson L, Kry S. A Review of Magnetic Shielding Technology for Space Radiation. Radiation 3(1):46-57, 2023. e-Pub 2023.
Editorials
- Guan F, Zhao L, Bronk JK, Maletić-Savatić M, Grosshans DR, Carlson DJ. Advances in the biological effects of ionizing radiation. Front Oncol 13, 2024. PMID: 38234403.
- Guan F, Bronk LF, Yue J, Mohan R, Chen Z. Innovations, advances, and challenges in precision radiation oncology physics. Prec Radiat Oncol 7(4):222-224, 2023.
Abstracts
- Guan F, Stewart RD, Carlson DJ. A mechanism-based approach for quantifying the biological effects of tumor hypoxia in particle therapy. 71st Annual Meeting of Radiation Research Society. e-Pub 2025.
- Zhong W, Han D, Guan F, Bond J, Adefres B, Robinson T, Roberts K, Chen Z, Draeger E. Impact of Lung Block Margins on Volumetric Lung Dose in Total Body Irradiation. The American Association of Physicists in Medicine (AAPM) Spring Clinical Meeting 2025, 2025. e-Pub 2025.
- Guan F, Bronk L, Kerr M, Li Y, Braby LA, Sobieski M, Wang X, Zhang X, Stephan C, Sahoo N, Zhu XR, Titt U, Grosshans DR, Mohan R. Interpreting the biological effects of particle therapy as a function of linear energy transfer (LET) and microdosimetric lineal energy spectrum. 2nd International Microdosimetry Workshop: towards Standardization for Clinical Practice, 2025. e-Pub 2025.
- Qi M, Lai Y, Bronk L, Guan F, Jia X. Exploring the Universal Correlation between DNA Damage Distribution and Cell Surviving Fraction in Photon, Proton, and Carbon Ion Irradiations. 67th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition. e-Pub 2025.
- Grayson M, Guan F, Gupta P, Li Y, Bronk L, Mohan R. Characterization of the relative sensitivity of lymphocytes and their subtypes as a function of proton dose and LET. 10th Annual Meeting of Particle Therapy Cooperative Group - North America (PTCOG-NA), 2024. e-Pub 2024.
- Guan F, Bronk L, Kerr M, Li Y, Braby LA, Wang X, Zhang X, Sahoo N, Zhu XR, Titt U, Grosshans DR, Mohan R. Microdosimetric biological weighting function to predict the relative biological effectiveness of proton and carbon ions. 10th Particle Therapy Cooperative Group - North America (PTCOG-NA), 2024. e-Pub 2024.
- Bronk L, Singh S, Bronk J, Guan F, Jiang D, Wang X, Zhu XR, Sahoo N, Koong AC, Mohan R, Lang F, Grosshans DR. Human-induced pluripotent stem cell derived cerebral organoids as a model of normal brain tissue response to proton radiation. 10th Particle Therapy Cooperative Group - North America (PTCOG-NA), 2024. e-Pub 2024.
- Chen H, Tressel L, Kim J, Han D, Guan F, Draeger E, Young M, Park HS, Johung K, Owens MK, Carlson DJ, Chen Z. Management of Patients with Cardiac Implantable Electronic Devices (CIED) on a New Reflexion Treatment Platform. 66th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2024. e-Pub 2024.
- Chen H, Lee M, Han D, Zhong W, Guan F, Draeger E, Chen J, Carlson DJ, Gaderlund B, Yang R. Efficient Parameterization of Reflexion X1 Beam Model for Robust Small-Target and Off-Axis Dosimetry. 66th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2024. e-Pub 2024.
- Grayson M, Guan F, Li Y, Mohan R. Characterization of the Relative Sensitivity of Lymphocytes and Their Subtypes As a Function of Proton Dose and LET. 66th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2024. e-Pub 2024.
- Zhong W, Chen Z, Lee M, Guan F, Chen H, Han D. Measurements of Small Field Output Correction Factors on a Reflexion Treatment Machine. 66th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2024. e-Pub 2024.
- Osenberg S, Parkitny L, Bronk L, Altidor L, LaGrone A, Trostle A, Jia J, Guan F, Gaber MW, Wan Y, Grosshans D, Chen H, Liu Z, Young D, Maletic-Savatic M. Human Brain Organoid Model for Studying the Effects of Space Radiation on Neurogenesis. NASA Human Research Program Investigators' Workshop, 2024. e-Pub 2024.
- Altidor L, Osenberg S, Parkitny L, Lei K, Chamakuri S, Bronk L, Guan F, Gaber MW, Grosshans D, Young D, Maletic-Savatic M. Evaluating NR2E1 agonists as potential new therapeutics for rescuing radiation-induced effects on neural stem cells and neurogenesis. NASA Human Research Program Investigators' Workshop, 2024. e-Pub 2024.
- Guan F, Donahue W, Biggs S, Jennings M, Draeger E, Potenziani M, Guo F, Chen H, Carlson D, Han D, Chen Z. 3D Gamma Analysis between Treatment Plans from Quasi-Beam-Matched Medical Linacs of the Identical Model. 65th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2023. e-Pub 2023.
- Bronk L, Singh S, Bronk J, Liu K, Guan F, Mohan R, Koong AC, Lang F, Schueler E, Grosshans DR. The Effects of Flash Radiation in an Advanced Model of Normal Human Brain Tissue. 65th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2023. e-Pub 2023.
- Sun X, Guan F, Biggs S, Jennings M, Wang Z, Wang W, Zhang T, Shi M, Zhao L. Impact of Setup Errors on the Robustness of Linac-Based Single-Isocenter Coplanar and Non-Coplanar VMAT Plans for Multiple Brain Metastases. 65th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2023. e-Pub 2023.
- Zhong W, Guan F, Guo F, Deng J, Chen Z, Chen H. Evaluation of Surface-Imaging-Guided Patient Positioning in Fast-Protocol Whole-Breast Treatments. 65th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2023. e-Pub 2023.
- Guan F, Jiang D, Wang X, Yang M, Iga K, Li Y, Bronk L, Bronk J, Sahoo N, Grosshans D, Koong AC, Titt U, Zhu XR, Mohan R. A Strategy to Increase the Radiation Field Size in a Proton Flash Setup for Preclinical Radiobiological Studies. 65th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2023. e-Pub 2023.
- Draeger E, Guan F, Chen Z, Tien C. Film-Based Transit Dose Measurement for a Brachytherapy Surface Applicator Using GafchromicTM EBT4 Film. 65th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2023. e-Pub 2023.
- Hartzell S, Guan F, Taylor P, Peterson C, Howell R, Kry S. Calculating the Relative Biological Effectiveness of Carbon Ion Radiotherapy by Common Models Using Measurable Microdosimetric Inputs. 65th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2023. e-Pub 2023.
- Guan F, Chen H, Aydin R, Zhong W, Draeger E, Guo F, Kim J, Tien C, Carlson D, Chen Z. Dosimetry of Internal Eye Shield Using the Newly Released GafchromicTM EBT4 Film with a Bolus-Aided Measurement Setup. 65th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2023. e-Pub 2023.
- Guan F, Draeger E, Carlson D, Chen Z, Tien C. Can Current Monotherapy High-dose-rate Prostate Brachytherapy Prescriptions Overcome Intrafractional DNA Damage Repair And 192Ir Source Decay?. American Brachytherapy Society’s 2023 Annual Meeting 22(5):S97-S98, 2023. e-Pub 2023.
- Osenberg S, Parkitny L, Bronk L, LaGrone A, Guan F, Gaber M, Grosshans D, Maletic-Savatic M. Human Forebrain Organoid Model for Studying the Effect of Space Radiation on Neurogenesis. 87th Symposium: Stem Cells, Cold Spring Harbor Laboratory, 2023. e-Pub 2023.
- Tien C, Draeger E, Guan F, Carlson DR, Chen Z. Utilization of a Virtual Clinical Trial to Characterize Sensitivity of the Linear-Quadratic Model. American Brachytherapy Society’s 2023 Annual Meeting, 2023. e-Pub 2023.
- Osenberg S, Parkitny L, Bronk L, LaGrone A, Guan F, Gaber M, Grosshans D, Maletic-Savatic M. Human Forebrain Organoid Model for Studying the Effect of Space Radiation on Neurogenesis. 87th Cold Spring Harbor Laboratory Symposium on Quantitative Biology, 2023. e-Pub 2023.
- Hartzell S, Guan F, Taylor P, Peterson C, Kry S. Estimating the RBE of carbon ion therapy by common models using measurable microdosimetric inputs. European Society of Radiotherapy and Oncology (ESTRO) 2023, 2023. e-Pub 2023.
- Bronk J, Bronk L, Singh S, Guan F, Wang X, Zhu XR, Schueler E, Jiang D, Mohan R, Koong AC, Lang F, Grosshans DR. Enhanced Radiation-Sparing Effects of Ultra-High Dose Rate Proton Radiation (FLASH-RT) in a Human Induced Pluripotent Stem Cell-Derived Cerebral Organoid Model. 64th American Society for Radiation Oncology (ASTRO) Annual Meeting, 2022. e-Pub 2022.
- Hartzell S, Taylor P, Guan F, Peterson C, Howell R, Kry S. Sensitivity of Carbon RBE Models to Reference Parameter Variations. 64th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2022. e-Pub 2022.
- Yang M, Wang X, Guan F, Titt U, Iga K, Jiang D, Katayose T, Umezawa M, Frank S, Zhu XR. Adaptation and dosimetric commissioning of a synchrotron-based proton beamline for FLASH experiments. 60th Annual Conference of the Particle Therapy Co-Operative Group, 2022. e-Pub 2022.
- Bronk J, Bronk L, Singh S, Guan F, Wang X, Zhu XR, Schueler E, Jiang D, Mohan R, Koong AC, Lang F, Grosshans DR. Expanding the Therapeutic Window with Ultra-high Dose Rate Proton Radiation (FLASH-RT) in a Human Cerebral Organoid Based Allogeneic Brain Tumor Model. 104th Annual Meeting of American Radium Society, 2022. e-Pub 2022.
- Parkitny L, Osenberg S, Bronk L, Lagrone A, Guan F, Gaber MW, Grosshans D, Maletic-Savatic M. Low-dose radiation impairs neurogenesis in human forebrain organoids. 50th Annual Meeting of Society for Neuroscience, 2021. e-Pub 2021.
- Bronk L, Bronk J, Singh S, Wang X, Jiang D, Guan F, Koong A, Mohan R, Lang F, Grosshans D. Human-Induced Pluripotent Stem Cell Derived Cerebral Organoids as a Model of Normal Brain Tissue Response to Proton Radiation. American Journal of Clinical Oncology-Cancer Clinical Trials 44(10):S37, 2021. e-Pub 2021.
- Lai Y, Shen C, Chi Y, Guan F, Jia X. A Biology-Driven Deep-Learning Based Cell Survival Model for Proton Radiation. 63rd American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2021. e-Pub 2021.
- Lee Y, Jiang D, Yang M, Wang X, Iga K, Zhu X, Koong A, Mohan R, Guan F. Differential Dose-Rate Effects On Pancreatic Cell Survival From Proton Therapy: FLASH Versus Conventional Dose Rate. 63rd American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2021. e-Pub 2021.
- Hartzell S, Guan F, Taylor P, Peterson C, Howell R, Kry S. Contribution of Nuclear Fragmentation to Dose and Relative Biological Effectiveness (RBE) Across Common RBE Models in Carbon Radiotherapy. 63rd American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition Virtual, 2021. e-Pub 2021.
- Wang Q, Titt U, Mohan R, Guan F, Yepes P. Optimization of a FLASH Proton Beam Using a Track-Repeating Algorithm. 63rd American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2021. e-Pub 2021.
- Osenberg S, Bronk L, Guan F, Parkitny L, Liu Z, Gaber MW, Young DW, Grosshans D, Maletic-Savatic M. Targeting neurogenesis to counteract space radiation effects on cognition and mood. NASA Human Research Program IWS 2021, 2021. e-Pub 2021.
- Guan F, Ma D, Bronk L, Titt U, Grosshans D, Mohan R. Microdosimetric analysis of protons, helium and carbon ions in a high-throughput cell irradiation experiment. 66th Annual Meeting of Radiation Research Society, 2020. e-Pub 2020.
- Ma D, Bronk L, Titt U, Wen Z, Mohan R, Grosshans D, Guan F. Biological effects of proton, helium and carbon ions: comparison between high-throughput experimental data and model predictions. 59th Annual Conference of the Particle Therapy Co-Operative Group, 2020. e-Pub 2020.
- Wen Z, Guan F, Yang M. Phantom study of metal artifact effect on CT number using a single source dual energy (twin beam) CT scanner. 59th Annual Conference of the Particle Therapy Co-Operative Group, 2020. e-Pub 2020.
- Ma D, Bronk L, Titt U, Grosshans D, Mohan R, Guan F. Evaluation of Different Physical Parameters to Interpret the Biological Effects of Particle Therapy. 62nd American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2020. e-Pub 2020.
- Hartzell S, Guan F, Vassiliev O, Taylor P, Peterson C, Kry S. Microdosimetric Assessment of Model Based Relative Biological Effectiveness in Carbon Ion Therapy. 62nd American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2020. e-Pub 2020.
- Hartzell S, Guan F, Vassiliev O, Taylor P, Peterson C, Kry S. Assessment of Microdosimetric Measurement Uncertainty in Carbon Ion Radiotherapy. 62nd American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2020. e-Pub 2020.
- Lopez B, Guan F, Rauch G, Kappadath S. Tumor-Specific 99mTc-Sestamibi Quantification in Molecular Breast Imaging with Monte Carlo Simulation. 62nd American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2020. e-Pub 2020.
- Ferrone K, Willis C, Ma J, Peterson L, Guan F, Kry S. Reducing Effective Dose and Cancer Risk for An Interplanetary Space Mission with Magnetic Shielding. 62nd American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2020. e-Pub 2020.
- Guan F, Ma D, Bronk L, Titt U, Grosshans D, Mohan R. Geant4-based Monte Carlo calculations of microdosimetric quantities of protons, helium and carbon ions for radiobiological studies. Joint International Conference on Supercomputing in Nuclear Applications + Monte Carlo 2020, 2020. e-Pub 2020.
- Guan F, Ma D, Bronk L, Kerr M, Chen M, Wang X, Sahoo N, Grosshans D, Mohan R. The biological effects of intensity-modulated proton therapy: a comparison between high-throughput experimental results and model predictions. 65th Annual Meeting of Radiation Research Society, 2019. e-Pub 2019.
- Bronk L, Kroger B, Ma D, Kerr M, Tran K, Yiu J, Titt U, Sahoo N, Guan F, Mohan F, Grosshans D. High-throughput spatial mapping of DNA repair response along the range of an 81.4 MeV proton beam. 65th Annual Meeting of Radiation Research Society, 2019. e-Pub 2019.
- Yiu J, Kroger B, Kerr M, Georges S, Latario S, Sahoo N, Guan F, Bronk L, Mohan R, Grosshans D. The Role of BRCA1 Mutation on Cellular Response to X-ray and Proton Radiotherapy. 65th Annual Meeting of Radiation Research Society, 2019. e-Pub 2019.
- Ma D, Bronk L, Kerr M, Yiu J, Chen M, Wang X, Sahoo N, Grosshans D, Mohan R, Guan F. Experimental comparison of the biological effects from two different beam scan patterns in intensity-modulated proton therapy. 65th Annual Meeting of Radiation Research Society, 2019. e-Pub 2019.
- Darne C, Robertson D, Alsanea F, Guan F, Pan T, Grosshans D, Gautam A, Beddar S. A Proton Radiography System Design Using a Liquid Scintillator Detector. 61st American Society for Radiation Oncology (ASTRO) Annual Meeting, 2019. e-Pub 2019.
- Guan F, Bronk L, Ma D, Kerr M, Wang X, Sahoo N, Grosshans D, Mohan R. Comparing the Microdosimetric Kinetic Model-Predicted Proton RBE Values using Constant and Variable Quadratic Beta Coefficients. 61st American Society for Radiation Oncology (ASTRO) Annual Meeting, 2019. e-Pub 2019.
- Hartzell S, Guan F, Vassiliev O, Taylor P, Peterson C, Kry S. Consistency of RBE Assessment in Carbon Ion Radiotherapy. 61st American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2019. e-Pub 2019.
- Hartzell S, Guan F, Vassiliev O, Peterson C, Taylor P, Kry S. Introducing Uncertainty to Measurement Based RBE Assessment in Carbon Ion Radiotherapy. 61st American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2019. e-Pub 2019.
- Ma D, Matthew K, Bronk L, Wang X, Sahoo N, Grosshans D, Mohan R, Guan F. Experimental Validation of the Enhancement of Biological Effects Using Enhanced-LET Proton Therapy. 61st American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2019. e-Pub 2019.
- Ma D, Bronk L, Kroger B, Kerr M, Wang X, Sahoo N, Mohan R, Grosshans D, Guan F. The effect of the microdosimetric spectrum on DNA double-strand break induction in proton therapy. 64th Annual Meeting of Radiation Research Society, 2018. e-Pub 2018.
- Guan F, Geng C, Carlson D, Bronk L, Ma D, Wang X, Grosshans D, Mohan R. Development of easy-to-implement biological dose optimization algorithms for particle radiobiology. 64th Annual Meeting of Radiation Research Society, 2018. e-Pub 2018.
- Guan F, Geng C, Carlson D, Bronk L, Gates D, Ma D, Kerr M, Wang X, Grosshans D, Mohan R. Repair-Misrepair-Fixation (RMF) Model-Based Biological Dose Optimization for Scanned Ion Beams. 60th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2018. e-Pub 2018.
- Bronk L, Kroger B, Ma D, Kerr M, Tran K, Teubner F, Patel D, Titt U, Sahoo N, Sulman E, Guan F, Mohan R, Grosshans D. Mapping Biological Effects Along a Scanned 81.4 MeV Proton Beam: LET Modulation of the DNA Repair Response. 60th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2018. e-Pub 2018.
- Newpower M, Patel D, Bronk L, Guan F, Grosshans D, Titt U, Mohan R. Applying a Saturation Correction to the Microdosimetric Kinetic Model Prediction for the Relative Biological Effectiveness of a Carbon Ion Beam. 60th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2018. e-Pub 2018.
- Guan F, Bronk L, Kerr M, Ma D, Wang X, Sahoo N, Mohan R, Grosshans D. The correlation of biological effects and physical parameters in proton therapy. CPRIT's Innovations in Cancer Prevention and Research Conference V, 2017. e-Pub 2017.
- Patel D, Bronk L, Guan F, Peeler C, Brons S, Dokic I, Abdollahi A, Jaekel O, Grosshans D, Mohan R, Titt U. MO-RAM-GePD-TT-2: Effect of Physics Based Monte Carlo Parameterization On the Accuracy of Transport Quantities. 59th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition 44(6), 2017. e-Pub 2017.
- Guan F, Bronk L, Kerr M, Ma D, Wang Y, Wang X, Li Y, Vassiliev O, Patel D, Titt U, Lin S, Grosshans D, Mohan R. TH-AB-605-8: Investigation of the Spatial Ionization Density Dependence of the DNA Damage in a Lung Cancer Cell Line with Proton Irradiations. 59th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition 44(6), 2017. e-Pub 2017.
- Newpower M, Vassiliev O, Guan F, Grosshans D, Bronk L, Mohan R. SU-K-108-2: A Novel Linear-Quadratic-Cubic Cell Survival Model for Proton Therapy Response Based On the Microdosimetric Quantity Specific Energy. 59th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition 44(6), 2017. e-Pub 2017.
- Vassiliev O, Guan F, Bronk L, Grosshans D, Mohan R. SU-I-GPD-T-103: An LET-Based Model of Proton RBE Consistent with New High Accuracy RBE Data Measured Near Distal Fall-Off. 59th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition 44(6), 2017. e-Pub 2017.
- Bronk L, Guan F, Ma D, Wang Y, Kerr M, Patel D, Titt U, Vassiliev O, Lin S, Mohan R, Grosshans D. SU-K-108-8: High-Throughput Proton Irradiations Uncover a Differential DNA Damage Repair Response to P53 Depletion in Two Lung Cancer Cell Lines. 59th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition 44(6), 2017. e-Pub 2017.
- Patel D, Bronk L, Guan F, Peeler C, Mirkovic D, Grosshans D, Jäkel O, Abdollahi A, Mohan R, Titt U. Experimental Investigation of RBE as a Function of Dose and LET. 25th Annual Meeting of the Council on Ionizing Radiation Measurements and Standards, 2017. e-Pub 2017.
- Guan F, Bronk L, Kerr M, Patel D, Peeler C, Mirkovic D, Titt U, Grosshans D, Mohan R. Innovations in spatial mapping of the RBE of scanned particle beams. 24th International Conference On The Application of Accelerators In Research And Industry, 2016. e-Pub 2016.
- Bronk L, Guan F, Kerr M, Ezhilarasan R, Sulman E, Mohan R, Grosshans D. Glioma stem cell survival as a function of dose and LET in a scanned proton beam using a spheroid growth assay. 62nd Annual Meeting of Radiation Research Society, 2016. e-Pub 2016.
- Guan F, Bronk L, Kerr M, Wang X, Li Y, Peeler C, Sahoo N, Mirkovic D, Titt U, Grosshans D, Mohan R. Spectral dependence of linear energy transfer on the biological effectiveness of therapeutic protons. 62nd Annual Meeting of Radiation Research Society, 2016. e-Pub 2016.
- Guan F, Bronk L, Kerr M, Wang X, Li Y, Peeler C, Sahoo N, Patel D, Mirkovic D, Titt U, Grosshans D, Mohan R. Investigation of LET Spectral Dependence of the Biological Effects of Therapeutic Protons. 58th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2016. e-Pub 2016.
- Kerr M, Bronk L, Guan F, Patel D, Li Y, Wang X, Sahoo N, Peeler C, Titt U, Mirkovic D, Grosshans D, Mohan R. Spatial mapping of scanned proton biologic effect using the high-throughput technique, continued. 58th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2016. e-Pub 2016.
- Patel D, Bronk L, Guan F, Peeler C, Mirkovic D, Grosshans D, Jakel O, Abdollahi A, Titt U, Mohan R. Experimental Investigation of RBE of Lung Cancer Cell Lines as a Function of Dose and LET in Proton, Helium and Carbon Beams. 58th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2016. e-Pub 2016.
- Titt U, Bronk L, Patel D, Guan F, Peeler C, Mohan R. In-vitro Survival of H460 and H1437 Cells as a Function of Dose and LET in Proton, Helium and Carbon beams. 55th Annual Conference of the Particle Therapy Co-Operative Group, 2016. e-Pub 2016.
- Peeler C, Taleei R, Guan F, Bronk L, Patel D, Titt U, Mirkovic D, Stewart R, Grosshans D, Mohan R. Relative Biological Effectiveness of Double-Strand Break Induction for Modeling Cell Survival in Pristine Proton Beams of Different Dose-Averaged Linear Energy Transfers. 57th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2015. e-Pub 2015.
- Guan F, Titt U, Patel D, Bronk L, Taleei R, Peeler C, Mirkovic D, Grosshans D, Jakel O, Mohan R. Experimental Design for High-Throughput In-Vitro RBE Measurements Using Protons, Helium and Carbon Ions. 57th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2015. e-Pub 2015.
- Guan F, Bronk L, Kerr M, Titt U, Wang X, Taleei R, Peeler C, Patel D, Mirkovic D, Grosshans D, Mohan R. Quantifying the Biological Effects of Therapeutic Protons by LET Spectrum Analysis. 57th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2015. e-Pub 2015.
- Geng C, Tang X, Guan F, Johns J, Vasudevan L, Gong C, Shu D, Chen D. A Comparative Study between Monte Carlo Code Geant4 and MCNP on Neutron Dose Calculations. 60th Annual Meeting of the Health Physics Society, 2015. e-Pub 2015.
- Taleei R, Peeler C, Guan F, Patel D, Titt U, Mirkovic D, Grosshans D, Mohan R. Modeling Biological Response to Proton Irradiation and Evaluating Its Potential Clinical Consequences. 57th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2015. e-Pub 2015.
- Guan F, Bronk L, Kerr M, Titt U, Lin S, Mirkovic D, Zhu XR, Sobieski M, Stephan C, Mohan R, Grosshans D. A Novel Technique for High-throughput, High-precision Spatial Mapping of the Biologic Effectiveness of Therapeutic Proton Beam. 60th Annual Meeting of Radiation Research Society, 2014. e-Pub 2014.
- Taleei R, Titt U, Peeler C, Guan F, Mirkovic D, Grosshans D, Mohan R. Modeling Physics Properties and Biologic Effects Induced by Proton and Helium Ions. 56th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2014. e-Pub 2014.
- Guan F, Johns J, Vasudevan L, Zhang G, Poston J, Braby L, Mohan R. A Novel Monte Carlo Algorithm for Solving the True Coincident Counting Issues in Monte Carlo Simulations for Gamma Spectroscopy. 59th Annual Meeting of the Health Physics Society, 2014. e-Pub 2014.
- Bronk L, Guan F, Kerr M, Titt U, Mirkovic D, Lin S, Mohan R, Grosshans D. High-throughput Mapping of Proton Biologic Effect. 56th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2014. e-Pub 2014.
- Peeler C, Taleei R, Guan F, Bronk L, Grosshans D, Mirkovic D, Titt U, Mohan R. Application of the Repair-Misrepair-Fixation RBE Model to Describe the Results of High Resolution Proton Irradiation Cell Survival Experiments. 56th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2014. e-Pub 2014.
- Randeniya S, Mirkovic D, Titt U, Guan F, Mohan R. Importance of energy dependent protons per MU calibration factors in IMPT dose calculations using Monte Carlo technique. 56th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2014. e-Pub 2014.
- Guan F, Bronk L, Kerr M, Titt U, Taleei R, Mirkovic D, Zhu XR, Grosshans D, Mohan R. The Effect of Particle Tracking Step Size Limit on Monte Carlo-Computed LET Spectrum of Therapeutic Proton Beams. 56th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2014. e-Pub 2014.
- Guan F, Titt U, Taleei R, Bangert M, Zhao L, Mirkovic D, Zhu Z, Bronk L, Kerr M, Sahoo N, Zhu XR, Gillin M, Carlson DJ, Grosshans DR, Mohan R. Monte Carlo Analysis of the Dose Contributions from Primary and Secondary Particles in Light-ion therapy. 53rd Annual Conference of the Particle Therapy Co-Operative Group, 2014. e-Pub 2014.
- Bronk L, Guan F, Kerr M, Titt U, Mirkovic D, Dinh J, Lin S, Mohan R, Grosshans DR. High-throughput Mapping of Proton Biologic Effect. 23rd International Conference on the Application of Accelerators in Research and Industry, 2014. e-Pub 2014.
- Peeler C, Taleei R, Guan F, Bronk L, Grosshans DR, Mirkovic D, Titt U, Mohan R. Radiobiological Modeling of High-Throughput Proton Irradiation Cell Survival Experiments. 23rd International Conference on the Application of Accelerators in Research and Industry, 2014. e-Pub 2014.
- Mirkovic D, Titt U, Randeniya S, Guan F, Peeler C, Ge S, Mohan R. Particle Therapy Research Group at MDACC. Horizons 2013: Connecting AAPM & PS-OCs, 2013. e-Pub 2013.
- Guan F, Mohan R, Dinh J, Kerr M, Perles L, Mirkovic D, Titt U, Zhu XR, Gillin M, Meyn R, Lin S, Grosshans DR. Experimental Design and Preliminary Results for High-Resolution and High-Throughput In-Vitro Measurements of Proton RBE. 55th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2013. e-Pub 2013.
- Titt U, Guan F, Mirkovic D, Mohan R. On the Out-Of-Field-Doses Caused by Secondary Particles From Light Ion Beams in Charged Particle Therapy. 55th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2013. e-Pub 2013.
- Guan F, Titt U, Bangert M, Mohan R. In Search of the Optimum Ion for Radiotherapy. 55th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2013. e-Pub 2013.
- Kerr M, Dhanesar S, Guan F, Taylor M, Zhu X, Gillin M, Amos R, Poenisch F, Sahoo N. Relative Proton Stopping Power Ratio Database for Common Dosimetry Phantom Materials. 55th American Association of Physicists in Medicine (AAPM) Annual Meeting & Exhibition, 2013. e-Pub 2013.
- Mohan R, Guan F, Dinh J, Kerr M, Mirkovic D, Titt U, Zhu R, Gillin M, Meyn R, Lin S, Grosshans DR. Experimental Design and Preliminary Results for High-Resolution and High-Throughput In-Vitro Measurements of Proton RBE. 52nd Annual Conference of the Particle Therapy Co-Operative Group (PTCOG), 2013. e-Pub 2013.
- Guan F, Poston J, Braby L. Joint Application of Perl Scripts and MCNPX in Solving the Dynamic-Geometry Related Problems in Proton Beam Radiotherapy. The Joint International Conference of the 7th Supercomputing in Nuclear Application and the 3rd Monte Carlo (SNA+MC 2010), 2010. e-Pub 2010.
- Guan F, Poston J, Braby L. Design and Simulation of a Passive-Scattering Nozzle in Proton Beam Radiotherapy. 55th Annual Meeting of the Health Physics Society, 2010. e-Pub 2010.
- Hartzell S, Guan F, Taylor P, Kry S. Calculating the relative biological effectiveness of carbon ion radiotherapy by common models using measurable microdosimetric inputs. 63rd Annual Conference of the Particle Therapy Co-Operative Group (PTCOG).
Book Chapters
- Mohan R, Titt U, Guan F. Chapter 2, Particle Therapy in the Third Millennium: Current Status and Future Outlook. In: Particle Radiotherapy—Emerging Technology for Treatment of Cancer. 1. Springer, 7-19, 2016.
Patient Reviews
CV information above last modified July 15, 2025