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Francois Villinger, DVM

Department of Comparative Medicine, Division of Division of Discovery Science

Present Title & Affiliation

Primary Appointment

Director and Chair, Department of Michale E. Keeling Center for Comparative Medicine and Research, Division of Discover Science, The University of Texas MD Anderson Cancer Center, Bastrop, Texas

Research Interests

Characterization of the immune response against SIV in the non-human primate model of human AIDS with a special emphasis on the delineation of the mechanisms by which natural SIV infection of select African non-human primates result in disease resistance whereas Asian non-human primates following experimental infection develop disease and die from an AIDS like syndrome remarkably similar to human AIDS.

Exploration of strategies to restore immune responses and antiviral immune responses following SIV infection using combination of antiviral treatment, immunization, immunotherapies and adoptive transfer of T cell effectors.

Enhanced understanding of HIV AIDS pathogenesis and viral and immune dynamics using imaging technologies. Delineation of HIV reservoirs.

HIV vaccine research and microbicide based prevention methods.

Exploration of dengue hemorrhagic fever using a NHP model in macaques.

Restoring vaccine efficacy in elderly macaques.

EBV targeted vaccine using the macaque LCV model.

Babesiosis as a threat to the US blood bank

Schistosoma japonicum vaccine

Zika virus infection and pathogenesis

Hepatitis B in cynomolgus macaques

COVID vaccines and immunity

Evaluation of experimental HCV vaccines in NHPs.

Dengue therapeutics in NHP models.

Exploratory uses of mRNA technology to generate mucosal barriers to infection

Education & Training

Postgraduate Training

1989-1991	Postgraduate Fellow, Study of Immune Mechanisms in AIDS using an Old World Primate Model for AIDS, Emory University, Atlanta, Georgia
1987-1989	Postgraduate Fellow, Immunology of African Swine Fever Virus Infection, USDA Plum Island Animal Disease Center, Greenport, NY

Licenses & Certifications

1986	Doctor of Veterinary Medicine
1984	Federal Swiss Veterinary License

Experience & Service

Faculty Academic Appointments

Professor (Tenured), Department of Biology, University of Louisiana at Lafeyette, Lafayette, Louisiana, 2017 - 2025

Professor Adjunct, Department of Biology, University of Louisiana at Lafayette, Lafeyette, Louisiana, 2015 - 2017

Professor, Department of Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, 2014 - 2016

Member, Department of Emory Center for AIDS Research, Emory University, Emory University, Georgia, 2010 - 2016

Member, Department of Emory Vaccine Center, Emory University, Atlanta, Georgia, 2008 - 2016

Professor, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, 2007 - 2016

Associate Director, Department of Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, 2007 - 2014

Associate Professor, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, 2004 - 2008

Assistant Professor, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, 1995 - 2004

Administrative Appointments/Responsibilities

Director, Department of New Iberia Research Center, University of Louisiana, Lafayette, Louisiana, 2015 - 2025

Associate Director, Department of Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, 2007 - 2014

Other Professional Positions

Guest Researcher, Centers for Disease Control, Atlanta, Georgia, 1995 - 1998

Guest Researcher, Centers for Disease Control, Atlanta, Georgia, 1989 - 2004

Assistant, veterinary laboratory diagnostics and research on highly contagious exotic animal diseases (Foot-and-Mouth disease, African and Swine Fever, Aujeszki, IBR/IPV, Bovine Virus Diarrhea, Transmissible Gastroenteritis and Rabies), Federal Vaccine Institute, Basel, 1984 - 1987

Assistant Veterinary Clinician, Multiple Clinics, 1982 - 1984

Extramural Institutional Committee Activities

Member, ZRG1 IDA-R-83 panel, NIH, 2025

Chair, ZAI1-TCB-I-M2 review panel, NIH, 2021

Reviewer, ANRS CSS11 Panel "Maladies Infectieuses Emergentes", Agence National de Recherche sur le SIDA (ANRS), 2021 - 2025

Member, Delaney Review Panel, NIH, 2021

Standing Member, Microbiology and Infectious Diseases Research Committee (MID-B), NIH/NIAID, 2021 - 2025

Chair, ZRG1 AATT-E(02) Special emphasis Panel, NIH, 2020

Chair, ZAI1 TCB-I NHP MHC and KIR Allele Discovery and Typing panel, NIH, 2020

Member, PAR Panel: ZRG1 GGG-D, NIH Genomics and Animal/Biological Resource Facilities, 2020

Member, ZHL1 CSR-1 R35 Outstanding Investigator Award Panel, NIH, 2020

Member, ZRG1 GGG-A panel, NIH, 2020

Member, Scientific Review Committee, 37th Annual Nonhuman Primate Models for AIDS Symposium, 2019 - 2019

Reviewer, Research Grant Council (RGC), University of Hong Kong, 2019

Member, ZRG1 GGG-D, NIH -Genomics and Animal/Biological Resource Facilities, 2019

Member, California HIV/AIDS Research Program (CHRP), Basic Biomedical Science Discovery Initiative, 2019

Member, Executive Committee, Department of Biology, UL Lafayette, 2019 - 2022

Member, CFAR Review Committee, NIH, 2018

Reviewer, Ministry of Health, Czech Republic, Czech Health Research Council, 2018

Member, ZRG1 AARR-K (59) R panel, NIH, 2018

N/A, ZTR1 Cl-4 (01) 1 CTSA Collaborative awards, NIH, 2018

Member, ZDE1 NB-18-1 NIDCR Special Emphasis panel, NIH, 2018

Member, Faculty Promotion Committee, Department of Biology, UL Lafayette, 2018 - 2025

Reviewer, Applied and Biomedical Research for the Italian ministry of Health, Italian Ministry of Health, 2018

Reviewer, Research Grant Council (RGC) of the University of Hong Kong, University of Hong-Kong, 2018

Member, Review Committee P01 special emphasis ZAI1 PA-I(S1)1, NIH/NIAID, 2017

Member, Review Committee Special Emphasis ZAG1 ZIJ-5 (O2), NIH/NIA, 2017

Member, Review Committee for the Canadian Fund for Innovation, FRSQ Canada, 2017

Member, Review Committee special emphasis CNS HIV reservoirs, NIH/NIAID, 2017

Reviewer, Research Grant Council (RGC) of Hong Kong, University of Hong Kong, 2017

Chair, Review Committee ZDE1 LC17, Oral HIVacc SEP, NIH, 2017

Member, Review Committee Zika Contract, NIH/NIAID, 2016

Member, LRP ZTR1 CI 4 01, NIH, 2016

Member, Review Committee ZRG1 IMST L, NIH, 2016 - 2016

Member, Review Committee for Martin Delaney ZAI-VV-A-M1 HIV Cure Programs, NIH, 2016

Ad Hoc Member, Review Committee, NIH/AIP, 2016

Member, ZRG1 AARR-K 56 R Special Emphasis Review Committee, NIH, 2016

Member, Scientific Review Committee, 33rd Annual Nonhuman Primate Models for AIDS Symposium, 2015 - Present

Member, NIA PO1 Review Committee, NIH/NIA, 2015 - 2015

Member, 2015/05 ZRG1 BBBP-Y (45) R Panel, NIH, 2015

Member, CSS1 ANRS study section on Host-virus interactions, ANRS, 2015 - 2020

Member, MEHP II, ZAl1 KP-A M1 1 Panel, NIH, 2015

Member, LRP-PR Review Panel, NIH, 2015

Member, Scientific Review Committee, 32th Annual Nonhuman Primate Models for AIDS Symposium, 2014 - Present

Member, Review Committee for the Canadian Fund for Innovation, FRSQ, 2014

Standing Member, NIH-STOD, NIH/ORIP, 2014 - 2016

Reviewer, Ministry of Health of the Czech Republic, Czech Health Council, 2014 - Present

Member, NIH/OD ZRG1 BBBP-Y Panel, NIH, 2014

Member, Review Committee for NIH/NCI contract (RFP N01RC51000-44), NIH/NCI, 2014

Member, Review Committee, University of Lyon, 2014

Member, Organizing Committee, 31st Annual Nonhuman Primate Models for AIDS Symposium, 2013 - Present

Member, Scientific Review Committee, AIDS 2013 Vaccine Symposium, 2013 - Present

Member, Scientific Review Committee, 30th Annual Nonhuman Primate Models for AIDS Symposium, 2012 - Present

Member, ZRG1 AARR-K02 “HIV/AIDS Immune Response and Vaccines special emphasis review panel, NIH, 2012

Chair, ZRG1 AARR-C 22 Special Emphasis Panel to review AIDS pre- and post-doctoral fellowship applications, NIH, 2012 - Present

Member, ZAI1 UKS-A “Next Generation PrEP II (R01) RFA-AI-11-023 Special emphasis review panel, NIH, 2012

Member, ZAI1-RB-A-M1”Next Generation PrEP (R01) Special emphasis panel, NIH, 2011

Member, Pfizer project review panel, Fonds de la Recherche Scientifique du Quebec, 2011 - 2012

Member, ZRG1 AARR-J Special emphasis panel, NIH, 2011

Member, Faculty Committee on Appointment and Promotion, Emory School of Medicine, 2010 - 2016

Member, NCRR Special Emphasis Panel for P30 (COBRE) applications, NIH/NCRR, 2010

Standing Member, Scientific and Technical Review Board on Biomedical and Behavioral Research Facilities, NIH/ORIP, 2010 - Present

member, Biology Review Panel, Agence Nationale de la Recherche (France), 2010

Member, Organizing Committee, AIDS 2010 Vaccine Symposium, 2009 - 2010

Member, ZRR1 STRB-8 Special Emphasis Panel/Scientific Review Panel, NIH, 2009 - 2010

Member, Emory Center for Aids Research Science Council, Emory University, 2009 - 2016

Chair, ZAI1-EC-A (M3) special emphasis panel, NIH/NIAID, 2009

Member, ZAI1 BDP-I-S1/S2 Challenge grants RC2, NIH, 2009

Member, ZRG1 IDM-C Challenge grants RC1 panel 9, NIH, 2009

Chair, ZDE1 VH special emphasis review Panel, NIH, 2009

Ad-Hoc reviewer, NIH ZRG1 AARR-C 22 study section, NIH, 2008 - Present

Member, Scientific Review COmmittee, 25th Annual Nonhuman Primate Models for AIDS Symposium, 2007 - Present

Ad Hoc Member, Site visit study section, NIH - Wisconsin National Primate Research Center, 2007 - Present

Chair of Virology Sessions, 24th Annual Nonhuman Primate Models for AIDS Symposium, 24th Annual Nonhuman Primate Models for AIDS Symposium, 2006 - Present

Member, Scientific Review Committee, 24th Annual Nonhuman Primate Models for AIDS Symposium, 2006 - Present

Member, Scientific Review Committee, 24th Annual Nonhuman Primate Models for AIDS Symposium, 2005 - Present

Ad Hoc member, NIH Novel HIV Therapies IPCP study section, NIH, 2004

ad hoc member, ZRR1 RI-1 NCRR COBRE study section, NIH, 2004

Member, NIH NCRR STTR Study section, NIH/NCRR, 2004 - Present

Member, CSS1 ANRS study section, Agence Nationals de Recherche sur the SIDA (ANRS), 2003 - 2007

Standing Member, ZRG1 HIV Vaccine study section, NIH, 2003 - 2008

Scientific Reviewer, CFAR developmental core applications, Emory University, 2002 - 2016

Member, Basic Sciences Review Panel, University of California, 2001 - 2006

Reviewer, Research Pilot Awards, University of Kansas Medical Center Research Institute, 2000 - 2001

Member, Institutional Animal Care and Use Committee, Emory University, 1998 - 2004

Member, Basic Sciences Review Panel, University of California, 1996 - 1997

Editorial Activities

Associate Editor, Frontiers in virology (Lausanne, Switzerland), 2010 - Present

Member, Experimental biology and medicine, 2009 - Present

Honors & Awards

2010 - Present	Woodruff Leadership Academy
1991 - 1994	Swiss National Funds for the advancement of Scientific Projects, Swiss National Funds

Professional Memberships

American Association of Immunology

2011 - Present

American Society for Microbiology

2010 - Present

Society for Experimental Biology and Medicine

2009 - Present

American Association for Laboratory Animal Science

2008 - Present

Selected Presentations & Talks

National Presentations

2023. improving T cell responses in nonhuman primate models of AIDS. Elkin Cancer Biology Seminars at the Winship Cancer Institute. Atlanta, Georgia, US.
2021. Addressing HIV reservoirs under ART requires investigating many compartments beyond blood. Invited, US.
2021. Committee of 100 for Economic Development. Collaborations against COVID-19 across Louisiana, US.
2020. NIRC contribution to the fight against COVID-19. Research Town Hall, US.
2019. Visualizing the kinetics of nanoparticles, virus and biomarkers in real time guides treatments. Invited. NanoBio Summit 2019, US.
2019. Mucosal delivery of TFV via hypo‐osmolar douche as an efficacious on demand alternative to oral daily PrEP to prevent the acquisition of HIV. Invited. 2019 HIV Mucosal Systems Meeting. Chicago, Illinois, US.
2019. Dynamics of SIV replication under ART and post ART Interruption identifies the most likely Functional Reservoir. Invited. Miami Winter Symposium 2019. Miami, Florida, US.
2019. If you cannot prevent HIV infection, try to find out where it goes. Invited. Third Coast CFAR invited presentation. Chicago, Illinois, US.
2018. Imaging SIV rebound in real time. Invited. The Collaboration for AIDS Vaccine Discovery. Seattle, Washington, US.
2018. Whole Body Imaging of HIV Persistence. Novel Imaging Technologies for Detection of HIV and Associated Inflammation/Pathology in the Brain. Invited. Rockville, Maryland, US.
2018. Imaging from macro to microscopic level, how to focus on mechanisms of disease. Invited. . LB-AALAS Keynote. Lafayette, Louisiana, US.
2018. Mapping total body viral replication and immune responses, from macro to microimaging. Invited. Montgomery, Alabama, US.
2016. SHIV: How to prevent its transmission but if it does follow its path!. Invited. Departmental presentation. Omaha, Nebraska, US.
2014. Dynamics Reservoirs of SIV under ART: Viral control is not uniform across all organs. Invited. ANRS AC32 HIV Reservoirs, US.
2014. Nonhuman Primate Models of Cancer: A limited choice. Invited. ACVP Workshop, US.
2014. Monoclonal antibody based microbicides against HIV and other STDs. Technological advances to a cost effective prevention. 2nd Conference on HIV-AIDS, STDs and STI. Las Vegas, Nevada, US.
2013. PET/CT Imaging of Simian Immunodeficiency Virus Reveals the Dynamics of Viral replication in vivo. Invited. 31st Annual Symposium on Nonhuman Primate Models for AIDS. Atlanta, Georgia, US.
2013. Chasing HIV viral reservoirs in real time using whole body immune-PET/CT. departmental seminar. Grenoble, FR.
2013. Tracking generalized virus infection in real time: The future is now!. Invited. ISU-Health Research Initiative, Infectious Diseases Symposium 2013. Ames, Iowa, US.
2013. “Pre-clinical models of personalized medicine. Monitoring therapy with non-invasive imaging. Invited. Symposium on personalized Medicine. Miami, Florida, US.
2012. “Imaging HIV in real time: the next clinical tool. Preliminary studies using SIV to monitor viremia, viral reservoirs and the dynamic of acute infection. CFAR seminars. Miami, Florida, US.
2012. Imaging HIV in real time: the next clinical tool. Preliminary studies using SIV to monitor viremia, viral reservoirs and the dynamic of acute infection. CFAR, US.
2012. Imaging Simian Immunodeficiency Virus infection: A tool for understanding HIV pathogenesis and monitoring therapy. Hradec Kralove, CZ.
2012. In vivo imaging of SIV and CD4+ T cells in rhesus macaques using PET/CT. Atlanta, Georgia, US.
2010. Nonhuman primate models of human retroviral infections: Dynamics of XMRV infection and immune restoration during chronic SIV infection. Montgomery, Alabama, US.
2010. Nonhuman primate models of human retroviral infections: Dynamics of XMRV infection and immune restoration during chronic SIV infection. Ames, Iowa, US.
2010. Nonhuman primate models of human retroviral infections: Dynamics of XMRV infection and immune restoration during chronic SIV infection. Philadelphia, Pennsylvania, US.
2010. Of mice monkeys and men, retroviruses infect them all! XMRV anyone?. Atlanta, Georgia, US.
2010. Of mice monkeys and men, retroviruses infect them all! XMRV anyone?. Atlanta, Georgia, US.
2008. CD4 T cell reeducation: Can we restore immune responses, control HIV/SIV replication and delay AIDS?. CFAR seminars. Miami, Florida, US.
2007. Anti-CD3/28 mediated expansion of macaque CD4+ T cells is polyclonal and provides extended survival after adoptive transfer in SIV infected macaques. Atlanta, Georgia, US.
2006. IL-15 effects in vivo: The view from the healthy and SIV-infected nonhuman primate. Invited. Basic Research and Clinical Applications, CIGC Seminar series. Bethesda, Maryland, US.
2006. Attempts to modulate immune responses and restore immune competency in the nonhuman primate model of AIDS. Fontenay-aux-Roses, FR.
2002. Manipulation of antigen specific responses using T cell stimulatory cytokines. Invited. North Central California Center for AIDS Research Symposium on “Anti-Viral Immunity in CMV and SIV Infection", California, US.
2002. Use of cytokine to alter immune responses and disease course in nonhuman primates. Bethesda, Maryland, US.
2001. Manipulation of immune responses and disease course in nonhuman primate AIDS. Paris, FR.
1998. Manipulation of immune responses in nonhuman primates, US.
1997. Early loss of antigen induced interferon gamma with gradual increase in IL-6 in macaques infected with SIVmac251 as they progress towards AIDS. Invited. Ninth Annual Meeting of the National Cooperative Vaccine Development Groups for AIDS, US.
1996. JISTEC Fellowship. Invited, US.

International Presentations

2025. Leveraging mRNA technologies to generate mucosal barriers to infection. Invited. KMINE 2025. Hradec Kralove, CZ.
2025. PET/CT guided tracking of viral reservoirs and viral rebound. Invited. EU2 Cure HIV Symposium. Ghent, BE.
2025. mRNA encoded antibodies to generate a protective barrier at the mucosa. Invited. Internation Conference on Emerging and Re-emerging Infectious Disease (ICER-ID 2015). Chennai, IN.
2025. mRNA applications in nonhuman primate models for improved preclinical evaluation. Invited. Conference of Research Workers in Animal Diseases (CRWAD). Chicago, US.
2024. Refining investigative approaches in NHP, leveraging imaging capabilities. Invited. Resource to Advance Pediatrics and HIV Prevention Science (RAPPS). New Orleans, US.
2024. PET/CT based imaging reveals immune occurrences in nonhuman primates. Invited. Invited talk. New York, US.
2024. Durable barrier to virus infection at the mucosa via mRNA transduction. Invited. 3rd HIV Mucosal Systems Meeting. Nashville, US.
2023. Chasing Viral Reservoirs and Antibody Dynamics in Nonhuman Primate Models: a key to understanding molecular processes. Invited. AVRS Conference 2023. Chennai, IN.
2023. Use of Nonhuman Primates as both a Preclinical and Basic Research Asset. Invited. Saveetha Medical Symposium. Chennai, IN.
2023. Mapping immune and viral dynamics in nonhuman primates: An exciting set of tools and glimpse into personalized medicine. Invited. One Heath Dubai. Dubai, AE.
2022. NIRC from a US NAVY base to the largest NHP center in the US. Invited. US-Canada Laboratory Animal Systems Forum. Buggugiate, IT.
2021. ImmunoPET/CT Imaging of SIV infection in real time reveals ongoing residual viral replication as one initial source of active HIV reservoirs. Invited. Total-Body PET 2021. Online, US.
2019. Rectal On demand PrEP as an effective and cost effective prevention of infection strategy. Invited. IDDHID. Chennai, IN.
2019. Identification and monitoring of HIV reservoirs under ART and post ART using whole body imaging. Invited. Chennai, IN.
2019. Translating Promising SIV monitoring to ATI studies in humans. 10th IAS Conference on HIV Science. Mexico City, MX.
2018. Mapping acute viral dynamics and rebound post ART interruption in SIV infected macaques using total body immunoPET/CT. Invited. HIVR4P. Madrid, ES.
2018. Tracking virus infection and immune responses in vivo: From macro to microscopic characterization. Invited. 12th Congress of the World Federation of Nuclear Medicine and Biology. Melbourne, AU.
2017. ImmunoPET/CT reveals the secret life of viruses and their targets in vivo. Invited. World Molecular Imaging Society Congree 2017. Philadelphia, US.
2015. HIV dynamics in vivo: Imaging totl body SIV replication in real time using immunoPET/CT reveals surprises. Invited. HIV Infection. Questions of diagnosis, treatment, prevention, prognosis. St Petersburg, RU.
2014. Anti-HIV Microbicides based on Broadly Neutralizing Antibodies. A Reality thanks to cost effective Production of Potent Human Antibodies in Nicotiana. Invited. Federation of African Immunologist Society Meeting. Nairobi, KE.
2014. Simian Immunodeficiency virus distribution and magnitude in vivo correlates with disease progression. Invited. BioHealth Computing Workshop. Grenoble, FR.
2014. Blockade of the Alpha4Beta7-Integrin Delays Vaginal SIV Acquisition and Viral Replication in vivo. Invited. International AIDS Society Meeting. Melbourne, AU.
2014. Simian Immunodeficiency Virus dynamics captured in real time. What we still need to learn and understand about HIV dynamics and reservoirs. Invited. Departmental Seminar. Brisbane, AU.
2014. Primate models of AIDS: Models for microbicide prevention and the study of early immune dynamics between virus and host in vivo. Invited. Departmental Seminar. Brisbane, AU.
2014. Nicotiana-produced broadly neutralizing anti-HIV monoclonal antibody based microbicides prevent vaginal SHIV acquisition in macaques. Invited. India Bio 2014. Bangalore, IN.
2014. Imaging Simian immunodeficiency in real time in vivo. Harnessing total body viral distribution, dynamics and reservoirs. Invited. Departmental seminar. Bangalore, IN.
2014. Real Time capture of Total Simian Immunodeficiency Virus replication in vivo. A new approach to evaluate viral distribution, dynamics and reservoirs. Invited. HIV Sciences 2014. Chennai, IN.
2013. Adoptive Transfer of autologous CD4+ T cells potentiates control of SIV. Invited. BIT’s 3rd Annual World Congress of Immunodiseases and Therapies. Dalian, CN.
2013. Nonhuman Primates not only as preclinical models for human therapies, vaccines but also as bona fide models for pathogenesis. Invited. Erasmus Mundus Masters Program 2013. Archamps, FR.
2013. Imaging SIV in real time: The reservoirs are not necessarily silent. Invited. IDMIT Kick-off Symposium: Animal Models for Infectious Diseases: State of the Art and Challenges, FR.
2011. In vivo imaging of SIV and CD4+ T cells in rhesus macaques using PET/CT. Invited. Imaging Conference at the Commissariat à l’Energie Atomique. Fontenay-aux-Roses, FR.
2008. Immune reconstitution of SIV infected macaques via transfusion of anti-CD3/28 expanded autologous CD4+ T cells: The transfused cells are needed for long term viral control. Invited. 26th Annual Symposium on Nonhuman Primate Models for AIDS. San Juan, PR.
2005. Manipulating and enhancing the immune response. Invited. d)AIDS Vaccines 2005, Roundtable participant in Symposium, CA.
1998. Control mechanisms of virus replication in naturally SIVsmm infected mangabeys and experimentally infected macaques. Invited. Second International Summit Meeting on: “Immunological Correlates of Protection from HIV Infection and Disease”, GB.

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Grant & Contract Support

Date:	2027 - 2028
Title:	Development of a bioadhesive vaginal film for extended release of MPT antibodies
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	HD-25-008

Date:	2027 - 2029
Title:	A universal vaccine targeting Plasmodium vivax infection
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	1R01AIxxxxx

Date:	2027 - 2028
Title:	An immunodominance-based Pan-Pneumovirus vaccine for protection against RSV and hMPV
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	1R01AI173416

Date:	2025 - 2030
Title:	Reversing effector-to-memory transition at ARTi to impact the HIV reservoirs towards ART-free control
Funding Source:	NIH/NIAID
Role:	Co-PI
ID:	R01AI192331

Date:	2025 - 2030
Title:	Reversing effector-to-memory transition at ARTi to impact the HIV reservoir towards ART-free control
Funding Source:	NIH/NIAID
Role:	Co-PI
ID:	R01AI192331

Date:	2025 - 2030
Title:	IL-15 Therapy combined with TGF-beta blockade for Sustained HIV
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	1R01AI187162

Date:	2025 - 2026
Title:	Design and develop Env trimer immunogens to induce CD4bs and trimer apex
Funding Source:	GATES Foundation
Role:	Co-I

Date:	2024 - 2029
Title:	Intrarectal Immunization for a Barrier to Mucosal HIV Infection
Funding Source:	NIH/NIAID
Role:	Co-PI
ID:	R01AI179412

Date:	2024 - 2029
Title:	Advancing Multi-bNAbs Microneedle Patch Technology For HIV-1 Prevention in Breastfeeding Infants (The MAMA Project)
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	1R01AI186784-01

Date:	2024 - 2029
Title:	Assessing the Role of GI Tract Dysfunction to HIV/SIV Disease Progression
Funding Source:	NIH/NIDDK
Role:	Co-I
ID:	2R01DK113919

Date:	2024 - 2025
Title:	New Strategy to Improve Gastrointestinal Health in SIV/HIV
Funding Source:	NIH/NIDDK
Role:	Co-I
ID:	5R01DK119936

Date:	2024 - 2025
Title:	IL-15 Therapy combined with TGF-beta blockade for Sustained HIV
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	1R56AI187162

Date:	2024 - 2028
Title:	Leveraging membrane Env liposome vaccine design to elicit multi-target cross-neutralization of HIV
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	1R01AI183472

Date:	2024 - 2026
Title:	SIV Pathogenesis in African Green Monkeys and Pigtailed Macaques
Funding Source:	NIH/NHLBI
Role:	Co-I
ID:	5R01HL117715

Date:	2023 - 2027
Title:	Expansion of Macaque Breeding Runs at the New Iberia Research Center
Funding Source:	NIH/OD/ORIP
Role:	PI
ID:	1C06OD035570

Date:	2023 - 2027
Title:	DAIDS ACC: Adjuvanting HIV vaccines supplement
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	75N93022C00052

Date:	2023 - 2024
Title:	Novel Macaque Breeding Runs at the New Iberia Research Center
Funding Source:	NIH/OD/ORIP
Role:	PI
ID:	1C06OD032071

Date:	2023 - 2025
Title:	Impact of metabolic programing of T cells from the GI tract and related tissues on HIV reservoir seeding, maintenance and reactivation
Funding Source:	NIH/NIDK
Role:	Co-I
ID:	5R01DK131476

Date:	2023 - 2028
Title:	Probing the role of adenosine pathway in SIV pathogenesis
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	1R01AI179317

Date:	2023 - 2025
Title:	Myocardial Vulnerability to Ischemia-Induced Dysfunction and Heart Failure: The Impact of HIV/SIV, ART, and Targeted Immunotherapy
Funding Source:	NIH/NHLBI
Role:	Co-I
ID:	5R01HL11154862

Date:	2023 - 2028
Title:	Turning off HIV White Noise: Switching from Long-Lived to Short-Lived Reservoir
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	1R01AI176599

Date:	2022 - 2026
Title:	Renovation of Building 29 laboratories at the New Iberia Research Center
Funding Source:	NIH/OD/ORIP
Role:	PI
ID:	1C06OD034041

Date:	2022 - 2025
Title:	Structure-based design of broadly protective coronavirus vaccines
Funding Source:	NIH/NIAID
Role:	PI
ID:	1P01AI167966

Date:	2022 - 2026
Title:	Durable HIV Vaccine Targeting Mucosal Epithelium
Funding Source:	NIH/NIAID
Role:	Co-PI
ID:	1R01AI172539

Date:	2022 - 2026
Title:	Durable HIV Vaccine Targeting Mucosal Epithelium
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	R01AI172539

Date:	2022 - 2025
Title:	Consortium for HIV/AIDS Vaccine Development (CHAVD)
Funding Source:	NCE
Role:	Co-I
ID:	5UM1 AI144462

Date:	2022 - 2027
Title:	Unraveling the Mechanisms of HIV Persistence and Rebound
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	1P01AI169600

Date:	2022 - 2025
Title:	Understanding Unconventional CD8+T Cell Responses in Protection from HIV
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	5R01AI140888

Date:	2022 - 2026
Title:	Resource for Nonhuman Primate Immune Reagents
Funding Source:	NIH/OD/ORIP
Role:	PI
ID:	R24OD010947

Date:	2022 - 2026
Title:	Role of myeloid cells in CNS and systemic reservoirs and rebound
Funding Source:	NIH/MH
Role:	Co-I
ID:	1R01MH125778

Date:	2021 - 2026
Title:	Sex Differences in intestinal immune dysfunction and SHIV persistence
Funding Source:	NIH/NIDDK
Role:	Co-PI
ID:	1R01DK130769

Date:	2021 - 2027
Title:	Identification of the Initial Targets of Transmission
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	5R37AI09495

Date:	2021 - 2026
Title:	A vaccine design to induce protective B and T cell immunity against hepatitis C virus
Funding Source:	NIH/NIAID
Role:	Key
ID:	1U19AI159840

Date:	2021 - 2026
Title:	Impact of antibody effector function diversity on antiviral activity in situ
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	1P01AI162242

Date:	2021 - 2023
Title:	TGFBR1 blockade as novel shock and kill HIV therapeutic strategy
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	R56AI157822

Date:	2020 - 2025
Title:	Identification of SIV replication and reservoirs in the CNS
Funding Source:	NIH/NIMH
Role:	Co-PI
ID:	1R01MH125395

Date:	2020 - 2026
Title:	Durable vaginal protection from HIV via mRNA expression of bnAbs
Funding Source:	NIH/NIAID
Role:	Co-PI
ID:	1R01AI155007

Date:	2020 - 2021
Title:	COVID-19: NJP adjuvant study
Funding Source:	GATES Foundation
Role:	Co-I
ID:	INV-018675

Date:	2020 - 2023
Title:	Mechanisms of Natural Killer Cell Clearance of SIV from Lymphoid Follicles
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	R01AI143457

Date:	2020 - 2027
Title:	SIV Vaccine Evaluation Unit (SVEU, Tasks 1,2,3 and 4)
Funding Source:	NIH/NIAID
Role:	PI

Date:	2020 - 2024
Title:	Hydrogel Sustained Reslease Antigen Delivery
Funding Source:	Bill and Melinda Gates Foundation
Role:	Co-I

Date:	2020 - 2024
Title:	Inducing broadly neutralizing antibodies by sequential germline targeting, shaping and polishing using the SOSIP trimer platform
Funding Source:	GATES Foundation
Role:	Co-I

Date:	2019 - 2023
Title:	Defense-in-depth against mucosal HIV clade C invasion
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	5P01AI048240

Date:	2019 - 2022
Title:	IND-enabling preclinical development of a system for the multipurpose prevention of HIV and unintended pregnancy
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	R44 AI124815

Date:	2019 - 2025
Title:	Synthetic mRNA-mediated reversible immunocontraception
Funding Source:	NIH/NIAIAD
Role:	Co-I
ID:	R61 HD099745

Date:	2019 - 2025
Title:	Cold chain-independent, needle-free mucosal virosomal vaccine to prevent HIV-1 acquisition at mucosal levels
Funding Source:	NIH/NIAID
Role:	PI
ID:	1U19 AI142636

Date:	2019 - 2024
Title:	Drug-eluting Fibers for on-demand and extended protection against HIV
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	5R01AI145483

Date:	2019 - 2020
Title:	Intravaginal delivery of mRNA, Mechanisms and Challenge Study
Funding Source:	GATES Foundation
Role:	Co-I
ID:	RK767-G3

Date:	2018 - 2025
Title:	Whole body to single cell analysis of the HIV reservoir
Funding Source:	NIH/NIAID
Role:	Co-PI
ID:	R01AI111907

Date:	2018 - 2017
Title:	Testing of mRNA dissemination and protein production after mRNA delivery IM
Funding Source:	Sanofi
Role:	Co-I

Date:	2018 - 2021
Title:	Adjuvanting a Malaria vaccine to induce robust and durable protective immunity
Funding Source:	GATES Foundation
Role:	Co-I

Date:	2017 - 2019
Title:	Testing antiretroviral (ARV) drugs in nonhuman primates HIV prophylactic efficacy models
Funding Source:	USAID
Role:	PI

Date:	2017 - 2022
Title:	Pathogenesis of Rebound SIV/HIV Viremia after Antiretroviral Therapy
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	1 P01 AI131346-01

Date:	2017 - 2020
Title:	Targeted nanocarriers to accelerate depletion of the HIV Reservoir
Funding Source:	AMFAR
Role:	Co-I
ID:	109541-61-RGRL

Date:	2017 - 2019
Title:	Combination HIV prevention in drug-eluting fibers: Designing for efficacy and use
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	5R01 AI112002

Date:	2017 - 2021
Title:	Efficacy of Heterodimeric IL-15 Treatment Regimens in Reducing SIV Reservoir
Funding Source:	NIH Foundation
Role:	Co-I
ID:	FNIH VILL17HETIL

Date:	2017 - 2020
Title:	SIV/HIV infection in adolescents
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	R01 AI112558

Date:	2016 - 2020
Title:	Mixed generation SOSIP.664-trimer based vaccines
Funding Source:	GATES Foundation
Role:	Co-I

Date:	2015 - 2020
Title:	Antibody responses in aging SIV infected monkeys
Funding Source:	NIH/NIAID
Role:	Co-PI
ID:	R01 AG047711

Date:	2014 - 2021
Title:	Role of antigen-specific T cell responses in the control of TB
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	U19 AI111211

Date:	2014 - 2017
Title:	Effective lethal agents for CCR5 expressing cells
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	R21 AI116230

Date:	2014 - 2020
Title:	Monitoring SIV Reservoirs with Whole Body ImmunoPET
Funding Source:	NIH/NIAID
Role:	PI
ID:	R01AI111907

Date:	2014 - 2019
Title:	Role of HIV Env Glycosylation in mucosal transmission
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	R01 AI113883

Date:	2014 - 2021
Title:	Development of Rectal Enema As Microbicide (DREAM)
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	U19 AI113127

Date:	2014 - 2019
Title:	Mucosal Protection Against HIV Generated by PIV5
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	R01 AI111863

Date:	2013 - 2015
Title:	Evaluation of acute babesiosis in rhesus macaques
Funding Source:	Abbott Laboratories
Role:	Co-I

Date:	2013 - 2018
Title:	Therapeutics Targeting Macrophages/ Microglia to Eradicate CNS HIV-1 Reservoirs
Funding Source:	NIH/NIMH
Role:	Co-I
ID:	1R01 MH100999

Date:	2013 - 2015
Title:	Immune Mechanisms of Long-Term Immunity induced by IPV
Funding Source:	WHO
Role:	Co-I

Date:	2013 - 2014
Title:	Quality Biologicals Inc. Adaptive immunity NHP immunization
Funding Source:	NHP
Role:	PI

Date:	2012 - 2015
Title:	Programming the magnitude and persistence of protective humoral responses against HIV
Funding Source:	GATES Foundation
Role:	Co-I

Date:	2012 - 2013
Title:	Do early Maternal Antibodies facilitate oral transmission of HIV to Infants
Funding Source:	NIH/NIDCR
Role:	Co-I
ID:	R01DE023049

Date:	2012 - 2017
Title:	Gut Homing Cells in SIV Infection
Funding Source:	NIh/NIAID
Role:	Co-I
ID:	R01 AI098628

Date:	2012 - 2013
Title:	Humoral Correlates of Protection Against HIV
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	R01AI100703

Date:	2011 - 2018
Title:	Monoclonal antibody based Multipurpose Microbicides: Project 5 Preclinical Evaluation in Nonhuman Primates
Funding Source:	NIH/NIAID
Role:	PI
ID:	1U19AI096398

Date:	2011 - 2013
Title:	Development of a non invasive whole body contrast agent for virus detection
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	1R21 AI095129

Date:	2011 - 2016
Title:	B-cell Biology of Mucosal Immune Protection from SIV Challenge
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	5U19 AI096187

Date:	2011 - 2012
Title:	Cross-clade passive immunization with human mAbs in rhesus monkey infants
Funding Source:	GATES Foundation
Role:	Co-I

Date:	2010 - 2011
Title:	Innate immune response during acute dengue virus infection
Funding Source:	NIH/NIAID
Role:	PI

Date:	2009 - 2011
Title:	Investigation of the link between XMRV and prostate cancer – mode of XMRV transmission
Funding Source:	Charlotte Geyer Foundation:
Role:	PI

Date:	2009 - 2011
Title:	A Therapeutic Vaccine for EBV-Associated Malignancies
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	1RC2CA148325

Date:	2009 - 2014
Title:	Modulation of the early host response to SIV in pathogenic infection
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	R01 AI084810

Date:	2009 - 2014
Title:	Th17 cells in AIDS pathogenesis and HIV vaccines
Funding Source:	NIH/NIAID
Role:	PI
ID:	R01 AI084836

Date:	2009 - 2012
Title:	A Durable Tolerance-Inducing Microcapsule
Funding Source:	Juvenile Diabetes Foundation
Role:	Co-I

Date:	2009 - 2011
Title:	Proposed GSK study in a Rhesus macaque SIV infection model of HIV infection
Funding Source:	Glaxo Smithkline
Role:	PI

Date:	2009 - 2010
Title:	Renovation of the Yerkes NPRC Pathology Laboratories
Funding Source:	NIH/NCRR
Role:	PI
ID:	1C06

Date:	2008 - 2013
Title:	Innate Immunity in SIV infection
Funding Source:	NIH
Role:	Co-I
ID:	1R01 AI098628

Date:	2008 - 2012
Title:	PD-1 modulation of SIV specific CD4 and CD8 T cell responses
Funding Source:	NIH/NIAID
Role:	PI
ID:	R01AI078775-01A2

Date:	2008 - 2009
Title:	Evaluation of Infection, Viral Dissemination and Immune Responses to the Gamma Human Retrovirus XMRV in Rhesus Macaques
Funding Source:	Abbott Diagnostics Inc
Role:	PI

Date:	2007 - 2016
Title:	Base grant support to the Yerkes NPRC
Funding Source:	NIH/NCRR
Role:	Co-I
ID:	P51-RR000165

Date:	2007 - 2012
Title:	Program Project Grant (Core C Primate Studies), Vaccination against HIV Clade C Transmission
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	P01AI048240

Date:	2005 - 2007
Title:	Investigation of Solvent Treated SIV as Autologous Candidate
Funding Source:	Lipid Sciences Inc
Role:	Co-I

Date:	2004 - 2006
Title:	Immunogenicity of Delipidated HIV in Primates
Funding Source:	Lipid Sciences Inc
Role:	Co-I

Date:	2004 - 2006
Title:	Role of Virus-specific T-cell Immunity in Primate AIDS
Funding Source:	NIH
Role:	Co-I
ID:	1RO1 AI027057

Date:	2004 - 2011
Title:	Modulating HIV immunity with dendritic cells
Funding Source:	NIH
Role:	Co-I

Date:	2003 - 2009
Title:	CD4 mediated immune reconstitution in SIV infection
Funding Source:	NIH/NHLBI
Role:	PI
ID:	1R01 HL075833

Date:	2002 - 2020
Title:	Resource for nonhuman primate Immune Reagents
Funding Source:	NIH/NCRR (now ORIP)
Role:	PI
ID:	R24OD010947

Date:	2002 - 2003
Title:	IL-16 mediated immune reconstitution during SIV infection
Funding Source:	Sedecim Therapeutics Inc
Role:	PI

Date:	1999 - 2004
Title:	HIV Infection/Cocaine Effect on Cardiovascular Pathology
Funding Source:	NIH
Role:	Co-I
ID:	RO1 HL047272

Date:	1998 - Present
Title:	Infant Immunoprophylaxis against a primate lentivirus
Funding Source:	NIH/NIAID
Role:	Co-I
ID:	1 R37 AI034266

Date:	1998 - 2004
Title:	DNA and protein immunogens for SIV/HIV vaccines
Funding Source:	NIH
Role:	Co-PI
ID:	P01 AI043045

Date:	1998 - 1999
Title:	Immune Reconstitution in SIV Infected Monkeys
Funding Source:	AMFAR
Role:	Co-I

Date:	1995 - 1999
Title:	Effect of SIV Infection on Hematopoietic Stem Cell Population
Funding Source:	NIH
Role:	Co-PI

Date:	1995 - 1998
Title:	Pediatric Model for Cytokine therapy in AIDS
Funding Source:	NIH
Role:	Co-I

Date:	1994 - 1998
Title:	Hantavirus Pulmonary Syndrome (HPS): Immunology
Funding Source:	CDC
Role:	Co-I

Date:	1994 - 1998
Title:	Genetic Immunization For Lentiviral Immunodeficiency Virus in Infection and Disease
Funding Source:	Univ. Cal at Davis, U.S. Army
Role:	PI

Selected Publications

Peer-Reviewed Articles

Manickam C, Jones R, Deb Adhikary NR, Kroll KW, Terry K, Balachandran H, Woolley G, Tomaras GD, Villinger FJ, Reeves RK. Myeloid cell recruitment and activation through systemic and mucosae-directed cytokine therapy. Immunol Cell Biol, 2025. e-Pub 2025. PMID: 41054306.
Acharya A, Sutar D, Mohan M, Govind V, Villinger F, Pallikkuth S, Byrareddy SN. Age-Associated Expansion of HIV/SIV Reservoirs in People With HIV and SIV-Infected Macaques. Aging Cell:e70252, 2025. e-Pub 2025. PMID: 41051053.
Spearman, P, Jin, H, Xiao, P, Knopp, K, Radziewicz, H, Tellier, M, Larsen, SE, Berube, BJ, Song, X, Kidd, J, Singh, K, Li, Z, Gingerich, MC, Wu, S, John, SP, Branche, A, Falsey, AR, Coler, R, Villinger, FJ, He, B. Safety and immunogenicity of intranasal parainfluenza virus type 5 (PIV5)–vectored COVID-19 vaccine in adults and teens in an open-label phase 1 trial. Science Advances 11(27), 2025. e-Pub 2025. PMID: 40614182.
Whitlow, HJ, Nagy, G, Kuznetsov, A, Frost, RJ, Azarov, A, Smith, KM, Amphalop, S, Insuan, W, Wichianchot, S, Ren, MQ, Osipowicz, T, Ryan, CG, Sudprasert, W, Villinger, FJ. Major and Trace Element Composition Differences Revealed in Porcine Intestine by Dynamic Analysis and MeV Ion Microscopy. Physica Status Solidi (A) Applications and Materials Science 222(12), 2025. e-Pub 2025.
Beavis, AC, Xiao, P, Gingerich, MC, Briggs, K, Li, G, Howerth, EW, Najera, M, An, D, Huang, J, Mousa, JJ, Tompkins, SM, Kim, G, Harvey, SB, Hogan, RJ, Lafontaine, ER, Villinger, FJ, Jin, H, He, B. A parainfluenza virus 5 (PIV5)-vectored intranasal SARS-CoV-2 vaccine (CVXGA1) elicits protective and long-lasting immunity in nonhuman primates. Journal of Virology 99(4), 2025. e-Pub 2025. PMID: 40116506.
Johnson, SD, Pino, M, Acharya, A, Clain, JA, Bose, D, Nguyen, K, Harper, J, Villinger, FJ, Paiardini, M, Byrareddy, SN. IL-21 and anti-α4β7 dual therapy during ART promotes immunological and microbiome responses in SIV-infected macaques. JCI Insight 10(6), 2025. e-Pub 2025. PMID: 39903521.
Peres A, Upadhyay AA, Klein VH, Saha S, Rodriguez OL, Vanwinkle ZM, Karunakaran K, Metz A, Lauer W, Lin MC, Melton T, Granholm L, Polak P, Peterson SM, Peterson EJ, Raju N, Shields K, Schultze S, Ton T, Ericsen A, Lapp SA, Villinger FJ, Ohlin M, Cottrell C, Amara RR, Derdeyn CA, Crotty S, Schief W, Karlsson Hedestam GB, Smith M, Lees W, Watson CT, Yaari G, Bosinger SE. A Broad Survey and Functional Analysis of Immunoglobulin Loci Variation in Rhesus Macaques. bioRxiv, 2025. e-Pub 2025. PMID: 39829807.
Buckley M, Arainga M, Maiorino L, Pires IS, Kim BJ, Michaels KK, Dye J, Qureshi K, Zhang YJ, Mak H, Steichen JM, Schief WR, Villinger F, Irvine DJ. Visualizing lipid nanoparticle trafficking for mRNA vaccine delivery in non-human primates. Mol Ther 33(3):1105-1117, 2025. e-Pub 2025. PMID: 39797396.
Govindaraj S, Ibegbu C, Ali SA, Babu H, Shanmugasundaram U, Villinger F, Amara RR, Velu V. IL-15/IL-15Ra Synergies with IL-12 to Induce Functional CD8 T Cells and NK Cells During Chronic SHIV Infection. AIDS Res Hum Retroviruses 41(3):120-123, 2025. e-Pub 2025. PMID: 39041621.
Bose D, Rogers KA, Shirreff LM, Chebloune Y, Villinger FJ. Enhanced HIV immune responses elicited by an apoptotic single-cycle SHIV lentivector DNA vaccine. Front Cell Infect Microbiol 15:1481427, 2025. e-Pub 2025. PMID: 40292218.
Yousefpour P, Zhang YJ, Maiorino L, Melo MB, Arainga Ramirez MA, Kumarapperuma SC, Xiao P, Silva M, Li N, Michaels KK, Georgeson E, Eskandarzadeh S, Kubitz M, Groschel B, Qureshi K, Fontenot J, Hangartner L, Nedellec R, Love JC, Burton DR, Schief WR, Villinger FJ, Irvine DJ. Modulation of antigen delivery and lymph node activation in nonhuman primates by saponin adjuvant saponin/monophosphoryl lipid A nanoparticle. PNAS Nexus 3(12):pgae529, 2024. e-Pub 2024. PMID: 39677368.
Taylor RA, Xiao S, Carias AM, McRaven MD, Thakkar DN, Arainga M, Lorenzo-Redondo R, Allen EJ, Rogers KA, Kumarapperuma SC, Gong S, Anderson MR, Thomas Y, Madden PJ, Corti D, Cameroni E, Lanzavecchia A, Goins B, Fox P, Villinger FJ, Ruprecht RM, Hope TJ. PET/CT Targeted Tissue Sampling Reveals Intravenously Administered HGN194 IgG1 Affects HIV Distribution after Rectal Exposure. AIDS Res Hum Retroviruses 40(11):637-648, 2024. e-Pub 2024. PMID: 39104250.
Milon TI, Wang Y, Fontenot RL, Khajouie P, Villinger F, Raghavan V, Xu W. Development of a novel representation of drug 3D structures and enhancement of the TSR-based method for probing drug and target interactions. Comput Biol Chem 112:108117, 2024. e-Pub 2024. PMID: 38852360.
Whitlow, HJ, Kuznetsov, A, Azarov, A, Nagy, G, Frost, RJ, Henderson, N, Greco, R, Deoli, N, Smith, KM, Sudprasert, W, Amphalop, S, Insuan, W, Wichianchot, S, Ren, MQ, Osipowicz, T, Ryan, CG, Villinger, FJ. Dynamic Analysis of major elements in biological tissue validating quantification of trace life elements in MeV ion beam microscopy. Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms 554, 2024. e-Pub 2024.
Nelson AN, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, Sewall LM, Milligan E, Davis D, Cross KA, Chen Y, van Schooten J, Eudailey J, Isaac J, Memon S, Weinbaum C, Gao H, Stanfield-Oakley S, Byrd A, Chutkan S, Berendam S, Cronin K, Yasmeen A, Alam S, LaBranche CC, Rogers K, Shirreff L, Cupo A, Derking R, Villinger F, Klasse PJ, Ferrari G, Williams WB, Hudgens MG, Ward AB, Montefiori DC, Van Rompay KKA, Wiehe K, Moore JP, Sanders RW, De Paris K, Permar SR. Immunization with germ line-targeting SOSIP trimers elicits broadly neutralizing antibody precursors in infant macaques. Sci Immunol 9(98):eadm7097, 2024. e-Pub 2024. PMID: 39213340.
Caniels TG, Medina-Ramirez M, Zhang S, Kratochvil S, Xian Y, Koo JH, Derking R, Samsel J, van Schooten J, Pecetta S, Lamperti E, Yuan M, Carrasco MR, Del Moral Sanchez I, Allen JD, Bouhuijs JH, Yasmeen A, Ketas TJ, Snitselaar JL, Bijl TPL, Martin IC, Torres JL, Cupo A, Shirreff L, Rogers K, Mason RD, Roederer M, Greene KM, Gao H, Silva CM, Baken IJL, Tian M, Alt FW, Pulendran B, Seaman MS, Crispin M, van Gils MJ, Montefiori DC, McDermott AB, Villinger FJ, Koup RA, Moore JP, Klasse PJ, Ozorowski G, Batista FD, Wilson IA, Ward AB, Sanders RW. Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site. Sci Immunol 9(98):eadk9550, 2024. e-Pub 2024. PMID: 39213338.
Yousefpour P, Zhang YJ, Maiorino L, Melo MB, Arainga Ramirez MA, Kumarapperuma SC, Xiao P, Silva M, Li N, Michaels KK, Georgeson E, Eskandarzadeh S, Kubitz M, Groschel B, Qureshi K, Fontenot J, Hangartner L, Nedellec R, Love JC, Burton DR, Schief WR, Villinger FJ, Irvine DJ. Modulation of antigen delivery and lymph node activation in non-human primates by saponin adjuvant SMNP. bioRxiv, 2024. e-Pub 2024. PMID: 39253464.
Arunachalam PS, Ha N, Dennison SM, Spreng RL, Seaton KE, Xiao P, Feng Y, Zarnitsyna VI, Kazmin D, Hu M, Santagata JM, Xie X, Rogers K, Shirreff LM, Chottin C, Spencer AJ, Dutta S, Prieto K, Julien JP, Tomai M, Fox CB, Villinger F, Hill AVS, Tomaras GD, Pulendran B. A comparative immunological assessment of multiple clinical-stage adjuvants for the R21 malaria vaccine in nonhuman primates. Sci Transl Med 16(758):eadn6605, 2024. e-Pub 2024. PMID: 39083589.
Buckley M, Arainga M, Maiorino L, Pires IS, Kim BJ, Michaels KK, Dye J, Qureshi K, Zhang Y, Mak H, Steichen JM, Schief WR, Villinger F, Irvine DJ. Visualizing lipid nanoparticle trafficking for mRNA vaccine delivery in non-human primates. bioRxiv, 2024. e-Pub 2024. PMID: 38979236.
Deycmar S, Johnson BJ, Ray K, Schaaf GW, Ryan DP, Cullin C, Dozier BL, Ferguson B, Bimber BN, Olson JD, Caudell DL, Whitlow CT, Solingapuram Sai KK, Romero EC, Villinger FJ, Burgos AG, Ainsworth HC, Miller LD, Hawkins GA, Chou JW, Gomes B, Hettich M, Ceppi M, Charo J, Cline JM. Epigenetic MLH1 silencing concurs with mismatch repair deficiency in sporadic, naturally occurring colorectal cancer in rhesus macaques. J Transl Med 22(1):292, 2024. e-Pub 2024. PMID: 38504345.
Bose D, Deb Adhikary N, Xiao P, Rogers KA, Ferrell DE, Cheng-Mayer C, Chang TL, Villinger F. SHIV-C109p5 NHP induces rapid disease progression in elderly macaques with extensive GI viral replication. J Virol 98(2):e0165223, 2024. e-Pub 2024. PMID: 38299866.
Kim J, Bose D, Arainga M, Haque MR, Fennessey CM, Caddell RA, Thomas Y, Ferrell DE, Ali S, Grody E, Goyal Y, Cicala C, Arthos J, Keele BF, Vaccari M, Lorenzo-Redondo R, Hope TJ, Villinger F, Martinelli E. TGF-beta blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo. Nat Commun 15(1):1348, 2024. e-Pub 2024. PMID: 38355731.
Winchester NE, Panigrahi S, Haria A, Chakraborty A, Su X, Chen B, Morris SR, Clagett BM, Juchnowski SM, Yadavalli R, Villinger F, Paiardini M, Harth K, Kashyap VS, Calabrese LH, Margolis L, Sieg SF, Shive CL, Gianella S, Funderburg NT, Zidar DA, Lederman MM, Freeman ML. Cytomegalovirus Infection Facilitates the Costimulation of CD57+CD28- CD8 T Cells in HIV Infection and Atherosclerosis via the CD2-LFA-3 Axis. J Immunol 212(2):245-257, 2024. e-Pub 2024. PMID: 38047900.
Yilma AN, Sahu R, Subbarayan P, Villinger F, Coats MT, Singh SR, Dennis VA. PLGA-Chitosan Encapsulated IL-10 Nanoparticles Modulate Chlamydia Inflammation in Mice. Int J Nanomedicine 19:1287-1301, 2024. e-Pub 2024. PMID: 38348174.
Kime J, Bose D, Arainga M, Haque MR, Fennessey CM, Caddell RA, Thomas Y, Ferrell DE, Ali S, Grody E, Goyal Y, Cicala C, Arthos J, Keele BF, Vaccari M, Lorenzo-Redondo R, Hope TJ, Villinger FJ, Marinelli E. TGF-beta blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo. bioRxiv, 2023. e-Pub 2023. PMID: 38014094.
Nelson AN, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, Sewall LM, Milligan E, Davis D, Cross KA, Chen Y, van Schooten J, Eudailey J, Isaac J, Memon S, Weinbaum C, Stanfield-Oakley S, Byrd A, Chutkan S, Berendam S, Cronin K, Yasmeen A, Alam SM, LaBranche CC, Rogers K, Shirreff L, Cupo A, Derking R, Villinger F, Klasse PJ, Ferrari G, Williams WB, Hudgens MG, Ward AB, Montefiori DC, Van Rompay KKA, Wiehe K, Moore JP, Sanders RW, De Paris K, Permar SR. Germline-targeting SOSIP trimer immunization elicits precursor CD4 binding-site targeting broadly neutralizing antibodies in infant macaques. bioRxiv, 2023. e-Pub 2023. PMID: 37986885.
Pallikkuth S, Kvistad D, Sirupangi T, Kizhner A, Pahwa R, Cameron MJ, Richardson B, Williams S, Ayupe A, Brooks M, Petrovas C, Villinger F, Pahwa S. IL-21-IgFc immunotherapy alters transcriptional landscape of lymph node cells leading to enhanced flu vaccine response in aging and SIV infection. Aging Cell 22(11):e13984, 2023. e-Pub 2023. PMID: 37712598.
Spearman P, Jin H, Knopp K, Xiao P, Gingerich MC, Kidd J, Singh K, Tellier M, Radziewicz H, Wu S, McGregor M, Freda B, Wang Z, John SP, Villinger FJ, He B. Intranasal parainfluenza virus type 5 (PIV5)-vectored RSV vaccine is safe and immunogenic in healthy adults in a phase 1 clinical study. Sci Adv 9(43):eadj7611, 2023. e-Pub 2023. PMID: 37878713.
Whitlow, HJ, Nagy, G, Henderson, N, Greco, R, Deoli, N, Smith, KM, Morgan, K, Villinger, FJ. Sequestration of Ca in simian nasal mucosa. Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms 539:152-161, 2023. e-Pub 2023.
Feng Y, Yuan M, Powers JM, Hu M, Munt JE, Arunachalam PS, Leist SR, Bellusci L, Kim J, Sprouse KR, Adams LE, Sundaramurthy S, Zhu X, Shirreff LM, Mallory ML, Scobey TD, Moreno A, O'Hagan DT, Kleanthous H, Villinger FJ, Veesler D, King NP, Suthar MS, Khurana S, Baric RS, Wilson IA, Pulendran B. Broadly neutralizing antibodies against sarbecoviruses generated by immunization of macaques with an AS03-adjuvanted COVID-19 vaccine. Sci Transl Med 15(695):eadg7404, 2023. e-Pub 2023. PMID: 37163615.
Drici, H, Adhikary, ND, Villinger, FJ, Hansen, EB. Dried Raw Camel Milk Spot (“DRCMS”) as a Simple and Efficient Microsampling Method from Hot and Remote Regions for Mesophilic Aerobe Count and Lactofermentation Microbiota Activity Detection. Food Analytical Methods 16(5):833-840, 2023. e-Pub 2023.
Weidenbacher PA, Sanyal M, Friedland N, Tang S, Arunachalam PS, Hu M, Kumru OS, Morris MK, Fontenot J, Shirreff L, Do J, Cheng YC, Vasudevan G, Feinberg MB, Villinger FJ, Hanson C, Joshi SB, Volkin DB, Pulendran B, Kim PS. A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates. Nat Commun 14(1):2149, 2023. e-Pub 2023. PMID: 37069151.
Khan M, Diop A, Gbodossou E, Xiao P, Coleman M, De Barros K, Duong H, Bond VC, Floyd V, Kondwani K, Rice VM, Harris-Hooker S, Villinger F, Powell MD. Anti-human immunodeficiency virus-1 activity of MoMo30 protein isolated from the traditional African medicinal plant Momordica balsamina. Virol J 20(1):50, 2023. e-Pub 2023. PMID: 36949470.
Rotolo L, Vanover D, Bruno NC, Peck HE, Zurla C, Murray J, Noel RK, O'Farrell L, Arainga M, Orr-Burks N, Joo JY, Chaves LCS, Jung Y, Beyersdorf J, Gumber S, Guerrero-Ferreira R, Cornejo S, Thoresen M, Olivier AK, Kuo KM, Gumbart JC, Woolums AR, Villinger F, Lafontaine ER, Hogan RJ, Finn MG, Santangelo PJ. Species-agnostic polymeric formulations for inhalable messenger RNA delivery to the lung. Nat Mater 22(3):369-379, 2023. e-Pub 2023. PMID: 36443576.
Feng Y, Yuan M, Powers JM, Hu M, Munt JE, Arunachalam PS, Leist SR, Bellusci L, Adams LE, Sundaramurthy S, Shirreff LM, Mallory ML, Scooby TD, Moreno A, O'Hagan DT, Kleanthous H, Villinger FJ, Veesler D, King NP, Suthar MS, Khurana S, Baric RS, Wilson IA, Pulendran B. Extremely potent pan-sarbecovirus neutralizing antibodies generated by immunization of macaques with an AS03-adjuvanted monovalent subunit vaccine against SARS-CoV-2. bioRxiv, 2023. e-Pub 2023. PMID: 36711543.
Tuyishime M, Spreng RL, Hueber B, Nohara J, Goodman D, Chan C, Barfield R, Beck WE, Jha S, Asdell S, Wiehe K, He MM, Easterhoff D, Conley HE, Hoxie T, Gurley T, Jones C, Adhikary ND, Villinger F, Thomas R, Denny TN, Moody MA, Tomaras GD, Pollara J, Reeves RK, Ferrari G. Multivariate analysis of FcR-mediated NK cell functions identifies unique clustering among humans and rhesus macaques. Front Immunol 14:1260377, 2023. e-Pub 2023. PMID: 38124734.
Weidenbacher PA, Sanyal M, Friedland N, Tang S, Arunachalam PS, Hu M, Kumru OS, Morris MK, Fontenot J, Shirreff L, Do J, Cheng YC, Vasudevan G, Feinberg MB, Villinger FJ, Hanson C, Joshi SB, Volkin DB, Pulendran B, Kim PS. A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates. bioRxiv, 2022. e-Pub 2022. PMID: 36597527.
Xiao P, Gumber S, Marzinke MA, Hoang T, Myers R, Date AA, Hanes J, Ensign LM, Wang L, Rohan LC, Cone R, Fuchs EJ, Hendrix CW, Villinger F. Hypo-osmolar rectal douche tenofovir formulation prevents simian/human immunodeficiency virus acquisition in macaques. JCI Insight 7(23), 2022. e-Pub 2022. PMID: 36477356.
Coleman MI, Khan M, Gbodossou E, Diop A, DeBarros K, Duong H, Bond VC, Floyd V, Kondwani K, Montgomery Rice V, Villinger F, Powell MD. Identification of a Novel Anti-HIV-1 Protein from Momordica balsamina Leaf Extract. Int J Environ Res Public Health 19(22), 2022. e-Pub 2022. PMID: 36429944.
Samer S, Thomas Y, Arainga M, Carter C, Shirreff LM, Arif MS, Avita JM, Frank I, McRaven MD, Thuruthiyil CT, Heybeli VB, Anderson MR, Owen B, Gaisin A, Bose D, Simons LM, Hultquist JF, Arthos J, Cicala C, Sereti I, Santangelo PJ, Lorenzo-Redondo R, Hope TJ, Villinger FJ, Martinelli E. Blockade of TGF-beta signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo. JCI Insight 7(21), 2022. e-Pub 2022. PMID: 36125890.
Seenappa LM, Jakubowski A, Steinbuck MP, Palmer E, Haqq CM, Carter C, Fontenot J, Villinger F, McNeil LK, DeMuth PC. Amphiphile-CpG vaccination induces potent lymph node activation and COVID-19 immunity in mice and non-human primates. NPJ Vaccines 7(1):128, 2022. e-Pub 2022. PMID: 36307453.
Walls AC, VanBlargan LA, Wu K, Choi A, Navarro MJ, Lee D, Avena L, Berrueta DM, Pham MN, Elbashir S, Kraft JC, Miranda MC, Kepl E, Johnson M, Blackstone A, Sprouse K, Fiala B, O'Connor MA, Brunette N, Arunachalam PS, Shirreff L, Rogers K, Carter L, Fuller DH, Villinger F, Pulendran B, Diamond MS, Edwards DK, King NP, Veesler D. Distinct sensitivities to SARS-CoV-2 variants in vaccinated humans and mice. Cell Rep 40(9):111299, 2022. e-Pub 2022. PMID: 35988541.
Arunachalam PS, Feng Y, Ashraf U, Hu M, Walls AC, Edara VV, Zarnitsyna VI, Aye PP, Golden N, Miranda MC, Green KWM, Threeton BM, Maness NJ, Beddingfield BJ, Bohm RP, Scheuermann SE, Goff K, Dufour J, Russell-Lodrigue K, Kepl E, Fiala B, Wrenn S, Ravichandran R, Ellis D, Carter L, Rogers K, Shirreff LM, Ferrell DE, Deb Adhikary NR, Fontenot J, Hammond HL, Frieman M, Grifoni A, Sette A, O'Hagan DT, Van Der Most R, Rappuoli R, Villinger F, Kleanthous H, Rappaport J, Suthar MS, Veesler D, Wang TT, King NP, Pulendran B. Durable protection against the SARS-CoV-2 Omicron variant is induced by an adjuvanted subunit vaccine. Sci Transl Med 14(658):eabq4130, 2022. e-Pub 2022. PMID: 35976993.
Hartwell BL, Melo MB, Xiao P, Lemnios AA, Li N, Chang JYH, Yu J, Gebre MS, Chang A, Maiorino L, Carter C, Moyer TJ, Dalvie NC, Rodriguez-Aponte SA, Rodrigues KA, Silva M, Suh H, Adams J, Fontenot J, Love JC, Barouch DH, Villinger F, Ruprecht RM, Irvine DJ. Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity. Sci Transl Med 14(654):eabn1413, 2022. e-Pub 2022. PMID: 35857825.
Rahman SA, Billingsley JM, Sharma AA, Styles TM, Govindaraj S, Shanmugasundaram U, Babu H, Riberio SP, Ali SA, Tharp GK, Ibegbu C, Waggoner SN, Johnson RP, Sekaly RP, Villinger F, Bosinger SE, Amara RR, Velu V. Lymph node CXCR5+ NK cells associate with control of chronic SHIV infection. JCI Insight 7(8), 2022. e-Pub 2022. PMID: 35271506.
Madden PJ, Thomas Y, Blair RV, Samer S, Doyle M, Midkiff CC, Doyle-Meyers LA, Becker ME, Arif MS, McRaven MD, Simons LM, Carias AM, Martinelli E, Lorenzo-Redondo R, Hultquist JF, Villinger FJ, Veazey RS, Hope TJ. An immunoPET probe to SARS-CoV-2 reveals early infection of the male genital tract in rhesus macaques. Res Sq, 2022. e-Pub 2022. PMID: 35411346.
Madden PJ, Thomas Y, Blair RV, Samer S, Doyle M, Midkiff CC, Doyle-Meyers LA, Becker ME, Arif MS, McRaven MD, Simons LM, Carias AM, Martinelli E, Lorenzo-Redondo R, Hultquist JF, Villinger FJ, Veazey RS, Hope TJ. An immunoPET probe to SARS-CoV-2 reveals early infection of the male genital tract in rhesus macaques. bioRxiv, 2022. e-Pub 2022. PMID: 35262081.
Leroy LA, Mac Donald A, Kandlur A, Bose D, Xiao P, Gagnon J, Villinger F, Chebloune Y. Cytokine Adjuvants IL-7 and IL-15 Improve Humoral Responses of a SHIV LentiDNA Vaccine in Animal Models. Vaccines (Basel) 10(3), 2022. e-Pub 2022. PMID: 35335093.
Leroy, LA, Donald, AM, Kandlur, A, Bose, D, Xiao, P, Gagnon, J, Villinger, FJ, Chebloune, Y. Cytokine Adjuvants IL-7 and IL-15 Improve Humoral Responses of a SHIV LentiDNA Vaccine in Animal Models. Vaccines 10(3), 2022. e-Pub 2022. PMID: 35335093.
Pillet S, Arunachalam PS, Andreani G, Golden N, Fontenot J, Aye PP, Roltgen K, Lehmicke G, Gobeil P, Dube C, Trepanier S, Charland N, D'Aoust MA, Russell-Lodrigue K, Monjure C, Blair RV, Boyd SD, Bohm RP, Rappaport J, Villinger F, Landry N, Pulendran B, Ward BJ. Safety, immunogenicity, and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates. Cell Mol Immunol 19(2):222-233, 2022. e-Pub 2022. PMID: 34983950.
Yee JL, Prongay K, Van Rompay KKA, Meesawat S, Kemthong T, Halley B, Carpenter A, Nham P, Rogers K, Hasselschwert D, Villinger F, Jay AN, Warit S, Malivijitnond S, Roberts JA. Tuberculosis detection in nonhuman primates is enhanced by use of testing algorithms that include an interferon-gamma release assay. Am J Vet Res 83(1):15-22, 2021. e-Pub 2021. PMID: 34757923.
Silveira ELV, Hong JJ, Amancha PK, Rogers KA, Ansari AA, Byrareddy SN, Villinger F. Viremia controls Env-specific antibody-secreting cell responses in simian immunodeficiency virus infected macaques pre and post-antiretroviral therapy. AIDS 35(13):2085-2094, 2021. e-Pub 2021. PMID: 34148985.
Taylor RA, McRaven MD, Carias AM, Anderson MR, Matias E, Arainga M, Allen EJ, Rogers KA, Gupta S, Kulkarni V, Lakhashe S, Lorenzo-Redondo R, Thomas Y, Strickland A, Villinger FJ, Ruprecht RM, Hope TJ. Localization of infection in neonatal rhesus macaques after oral viral challenge. PLoS Pathog 17(11):e1009855, 2021. e-Pub 2021. PMID: 34793582.
Abraham M, Beavis AC, Xiao P, Villinger FJ, Li Z, Jones CA, Tompkins SM, He B. Evaluation of a New Viral Vaccine Vector in Mice and Rhesus Macaques: J Paramyxovirus Expressing Hemagglutinin of Influenza A Virus H5N1. J Virol 95(22):e0132121, 2021. e-Pub 2021. PMID: 34469242.
Kvistad D, Pallikkuth S, Sirupangi T, Pahwa R, Kizhner A, Petrovas C, Villinger F, Pahwa S. IL-21 enhances influenza vaccine responses in aged macaques with suppressed SIV infection. JCI Insight 6(20), 2021. e-Pub 2021. PMID: 34491910.
Walls AC, Miranda MC, Schafer A, Pham MN, Greaney A, Arunachalam PS, Navarro MJ, Tortorici MA, Rogers K, O'Connor MA, Shirreff L, Ferrell DE, Bowen J, Brunette N, Kepl E, Zepeda SK, Starr T, Hsieh CL, Fiala B, Wrenn S, Pettie D, Sydeman C, Sprouse KR, Johnson M, Blackstone A, Ravichandran R, Ogohara C, Carter L, Tilles SW, Rappuoli R, Leist SR, Martinez DR, Clark M, Tisch R, O'Hagan DT, Van Der Most R, Van Voorhis WC, Corti D, McLellan JS, Kleanthous H, Sheahan TP, Smith KD, Fuller DH, Villinger F, Bloom J, Pulendran B, Baric RS, King NP, Veesler D. Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines. Cell 184(21):5432-5447.e16, 2021. e-Pub 2021. PMID: 34619077.
Carias AM, Schneider JR, Madden P, Lorenzo-Redondo R, Arainga M, Pegu A, Cianci GC, Maric D, Villinger F, Mascola JR, Veazey RS, Hope TJ. Anatomic Distribution of Intravenously Injected IgG Takes Approximately 1 Week to Achieve Stratum Corneum Saturation in Vaginal Tissues. J Immunol 207(2):505-511, 2021. e-Pub 2021. PMID: 34162723.
Berard AR, Miller C, Arainga M, Broedlow CA, Noel-Romas L, Schifanella L, Hensley-McBain T, Roederer A, Driscoll CB, Coronado E, Manuzak J, McKinnon LR, Villinger F, Hope TJ, Burgener AD, Klatt NR. Simian Immunodeficiency Virus Susceptibility, Immunology, and Microbiome in the Female Genital Tract of Adolescent Versus Adult Pigtail Macaques. AIDS Res Hum Retroviruses 37(7):510-522, 2021. e-Pub 2021. PMID: 33446027.
Arunachalam PS, Walls AC, Golden N, Atyeo C, Fischinger S, Li C, Aye P, Navarro MJ, Lai L, Edara VV, Roltgen K, Rogers K, Shirreff L, Ferrell DE, Wrenn S, Pettie D, Kraft JC, Miranda MC, Kepl E, Sydeman C, Brunette N, Murphy M, Fiala B, Carter L, White AG, Trisal M, Hsieh CL, Russell-Lodrigue K, Monjure C, Dufour J, Spencer S, Doyle-Meyers L, Bohm RP, Maness NJ, Roy C, Plante JA, Plante KS, Zhu A, Gorman MJ, Shin S, Shen X, Fontenot J, Gupta S, O'Hagan DT, Van Der Most R, Rappuoli R, Coffman RL, Novack D, McLellan JS, Subramaniam S, Montefiori D, Boyd SD, Flynn JL, Alter G, Villinger F, Kleanthous H, Rappaport J, Suthar MS, King NP, Veesler D, Pulendran B. Adjuvanting a subunit COVID-19 vaccine to induce protective immunity. Nature 594(7862):253-258, 2021. e-Pub 2021. PMID: 33873199.
Taylor RA, Xiao S, Carias AM, McRaven MD, Thakkar DN, Arainga M, Allen EJ, Rogers KA, Kumarapperuma SC, Gong S, Fought AJ, Anderson MR, Thomas Y, Schneider JR, Goins B, Fox P, Villinger FJ, Ruprecht RM, Hope TJ. PET/CT targeted tissue sampling reveals virus specific dIgA can alter the distribution and localization of HIV after rectal exposure. PLoS Pathog 17(6):e1009632, 2021. e-Pub 2021. PMID: 34061907.
Harper J, Huot N, Micci L, Tharp G, King C, Rascle P, Shenvi N, Wang H, Galardi C, Upadhyay AA, Villinger F, Lifson J, Silvestri G, Easley K, Jacquelin B, Bosinger S, Muller-Trutwin M, Paiardini M. IL-21 and IFNalpha therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques. Nat Commun 12(1):2866, 2021. e-Pub 2021. PMID: 34001890.
Walls AC, Miranda MC, Pham MN, Schafer A, Greaney A, Arunachalam PS, Navarro MJ, Tortorici MA, Rogers K, O'Connor MA, Shireff L, Ferrell DE, Brunette N, Kepl E, Bowen J, Zepeda SK, Starr T, Hsieh CL, Fiala B, Wrenn S, Pettie D, Sydeman C, Johnson M, Blackstone A, Ravichandran R, Ogohara C, Carter L, Tilles SW, Rappuoli R, O'Hagan DT, Van Der Most R, Van Voorhis WC, McLellan JS, Kleanthous H, Sheahan TP, Fuller DH, Villinger F, Bloom J, Pulendran B, Baric R, King N, Veesler D. Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines. bioRxiv, 2021. e-Pub 2021. PMID: 33758839.
Chege GK, Adams CH, Keyser AT, Bekker V, Morris L, Villinger FJ, Williamson AL, Chapman RE. Infection of Chinese Rhesus Monkeys with a Subtype C SHIV Resulted in Attenuated In Vivo Viral Replication Despite Successful Animal-to-Animal Serial Passages. Viruses 13(3), 2021. e-Pub 2021. PMID: 33801437.
S Arunachalam P, Walls AC, Golden N, Atyeo C, Fischinger S, Li C, Aye P, Navarro MJ, Lai L, Edara VV, Roltgen K, Rogers K, Shirreff L, Ferrell DE, Wrenn S, Pettie D, Kraft JC, Miranda MC, Kepl E, Sydeman C, Brunette N, Murphy M, Fiala B, Carter L, White AG, Trisal M, Hsieh CL, Russell-Lodrigue K, Monjure C, Dufour J, Doyle-Meyer L, Bohm RB, Maness NJ, Roy C, Plante JA, Plante KS, Zhu A, Gorman MJ, Shin S, Shen X, Fontenot J, Gupta S, O Hagan DT, Most RV, Rappuoli R, Coffman RL, Novack D, McLellan JS, Subramaniam S, Montefiori D, Boyd SD, Flynn JL, Alter G, Villinger F, Kleanthous H, Rappaport J, Suthar M, King NP, Veesler D, Pulendran B. Adjuvanting a subunit SARS-CoV-2 nanoparticle vaccine to induce protective immunity in non-human primates. bioRxiv, 2021. e-Pub 2021. PMID: 33594366.
Pallikkuth S, Mendez R, Russell K, Sirupangi T, Kvistad D, Pahwa R, Villinger F, Banerjee S, Pahwa S. Age Associated Microbiome and Microbial Metabolites Modulation and Its Association With Systemic Inflammation in a Rhesus Macaque Model. Front Immunol 12:748397, 2021. e-Pub 2021. PMID: 34737748.
Gong S, Lakhashe SK, Hariraju D, Scinto H, Lanzavecchia A, Cameroni E, Corti D, Ratcliffe SJ, Rogers KA, Xiao P, Fontenot J, Villinger F, Ruprecht RM. Cooperation Between Systemic IgG1 and Mucosal Dimeric IgA2 Monoclonal Anti-HIV Env Antibodies: Passive Immunization Protects Indian Rhesus Macaques Against Mucosal SHIV Challenges. Front Immunol 12:705592, 2021. e-Pub 2021. PMID: 34413855.
Xiao P, Dienger-Stambaugh K, Chen X, Wei H, Phan S, Beavis AC, Singh K, Adhikary NRD, Tiwari P, Villinger F, He B, Spearman P. Parainfluenza Virus 5 Priming Followed by SIV/HIV Virus-Like-Particle Boosting Induces Potent and Durable Immune Responses in Nonhuman Primates. Front Immunol 12:623996, 2021. e-Pub 2021. PMID: 33717130.
Madden PJ, Arif MS, Becker ME, McRaven MD, Carias AM, Lorenzo-Redondo R, Xiao S, Midkiff CC, Blair RV, Potter EL, Martin-Sancho L, Dodson A, Martinelli E, Todd JM, Villinger FJ, Chanda SK, Aye PP, Roy CJ, Roederer M, Lewis MG, Veazey RS, Hope TJ. Development of an In Vivo Probe to Track SARS-CoV-2 Infection in Rhesus Macaques. Front Immunol 12:810047, 2021. e-Pub 2021. PMID: 35003140.
Watanabe S, Fujino M, Saito Y, Ahmed N, Sato H, Sugimoto C, Okamura T, Hanaki K, Nakayama EE, Shioda T, Matsushima K, Ansari AA, Villinger F, Mori K. Protective Immune Responses Elicited by Deglycosylated Live-Attenuated Simian Immunodeficiency Virus Vaccine Are Associated with IL-15 Effector Functions. J Immunol 205(5):1331-1344, 2020. e-Pub 2020. PMID: 32747501.
Panigrahi S, Chen B, Fang M, Potashnikova D, Komissarov AA, Lebedeva A, Michaelson GM, Wyrick JM, Morris SR, Sieg SF, Paiardini M, Villinger FJ, Harth K, Kashyap VS, Cameron MJ, Cameron CM, Vasilieva E, Margolis L, Younes SA, Funderburg NT, Zidar DA, Lederman MM, Freeman ML. CX3CL1 and IL-15 Promote CD8 T cell chemoattraction in HIV and in atherosclerosis. PLoS Pathog 16(9):e1008885, 2020. e-Pub 2020. PMID: 32976527.
Koo BS, Hwang EH, Kim G, Park JY, Oh H, Lim KS, Kang P, Lee HY, Jeong KJ, Mo I, Villinger F, Hong JJ. Prevalence and characterization of Clostridium perfringens isolated from feces of captive cynomolgus monkeys (Macaca fascicularis). Anaerobe 64:102236, 2020. e-Pub 2020. PMID: 32623046.
Kasturi SP, Rasheed MAU, Havenar-Daughton C, Pham M, Legere T, Sher ZJ, Kovalenkov Y, Gumber S, Huang JY, Gottardo R, Fulp W, Sato A, Sawant S, Stanfield-Oakley S, Yates N, LaBranche C, Alam SM, Tomaras G, Ferrari G, Montefiori D, Wrammert J, Villinger F, Tomai M, Vasilakos J, Fox CB, Reed SG, Haynes BF, Crotty S, Ahmed R, Pulendran B. 3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope-specific plasma cells and humoral immunity in nonhuman primates. Sci Immunol 5(48), 2020. e-Pub 2020. PMID: 32561559.
Chebloune Y, Moussa M, Arrode-Bruses G, Ronfort C, Bose D, Gagnon J, Gumber S, Villinger T, Byrareddy SN, Kozlowski PA, Gosse L, Dereuddre-Bosquet N, Le Grand R, Villinger F. A single lentivector DNA based immunization contains a late heterologous SIVmac251 mucosal challenge infection. Vaccine 38(21):3729-3739, 2020. e-Pub 2020. PMID: 32278522.
Singh K, Marasini B, Chen X, Ding L, Wang JJ, Xiao P, Villinger F, Spearman P. A Bivalent, Spherical Virus-Like Particle Vaccine Enhances Breadth of Immune Responses against Pathogenic Ebola Viruses in Rhesus Macaques. J Virol 94(9), 2020. e-Pub 2020. PMID: 32075939.
Lindsay KE, Vanover D, Thoresen M, King H, Xiao P, Badial P, Arainga M, Park SB, Tiwari PM, Peck HE, Blanchard EL, Feugang JM, Olivier AK, Zurla C, Villinger F, Woolums AR, Santangelo PJ. Aerosol Delivery of Synthetic mRNA to Vaginal Mucosa Leads to Durable Expression of Broadly Neutralizing Antibodies against HIV. Mol Ther 28(3):805-819, 2020. e-Pub 2020. PMID: 31995741.
Villinger F. In-vivo use of SIVmac239 with a reversing stop codon in the SIV nef gene. AIDS 34(3):487, 2020. e-Pub 2020. PMID: 31996597.
Koo BS, Baek SH, Kim G, Hwang EH, Oh H, Son Y, Lim KS, Kang P, Lee HY, Jeong KJ, Kim YH, Villinger F, Hong JJ. Idiopathic chronic diarrhea associated with dysbiosis in a captive cynomolgus macaque (Macaca fascicularis). J Med Primatol 49(1):56-59, 2020. e-Pub 2020. PMID: 31642533.
Shankwitz K, Pallikkuth S, Sirupangi T, Kirk Kvistad D, Russel KB, Pahwa R, Gama L, Koup RA, Pan L, Villinger F, Pahwa S, Petrovas C. Compromised steady-state germinal center activity with age in nonhuman primates. Aging Cell 19(2):e13087, 2020. e-Pub 2020. PMID: 31840398.
Pino M, Uppada SB, Pandey K, King C, Nguyen K, Shim I, Rogers K, Villinger F, Paiardini M, Byrareddy SN. Safety and Immunological Evaluation of Interleukin-21 Plus Anti-alpha4beta7 mAb Combination Therapy in Rhesus Macaques. Front Immunol 11:1275, 2020. e-Pub 2020. PMID: 32765488.
Chamcha V, Reddy PBJ, Kannanganat S, Wilkins C, Gangadhara S, Velu V, Green R, Law GL, Chang J, Bowen JR, Kozlowski PA, Lifton M, Santra S, Legere T, Chea LS, Chennareddi L, Yu T, Suthar MS, Silvestri G, Derdeyn CA, Gale M Jr, Villinger F, Hunter E, Amara RR. Strong T(H)1-biased CD4 T cell responses are associated with diminished SIV vaccine efficacy. Sci Transl Med 11(519), 2019. e-Pub 2019. PMID: 31748228.
Hamorsky KT, Kouokam JC, Dent MW, Grooms TN, Husk AS, Hume SD, Rogers KA, Villinger F, Morris MK, Hanson CV, Matoba N. Engineering of a Lectibody Targeting High-Mannose-Type Glycans of the HIV Envelope. Mol Ther 27(11):2038-2052, 2019. e-Pub 2019. PMID: 31471224.
Duncan SA, Dixit S, Sahu R, Martin D, Baganizi DR, Nyairo E, Villinger F, Singh SR, Dennis VA. Prolonged Release and Functionality of Interleukin-10 Encapsulated within PLA-PEG Nanoparticles. Nanomaterials (Basel) 9(8), 2019. e-Pub 2019. PMID: 31357440.
Sindberg GM, Callen SE, Banerjee S, Meng J, Hale VL, Hegde R, Cheney PD, Villinger F, Roy S, Buch S. Morphine Potentiates Dysbiotic Microbial and Metabolic Shifts in Acute SIV Infection. J Neuroimmune Pharmacol 14(2):200-214, 2019. e-Pub 2019. PMID: 30242614.
Matchett WE, Anguiano-Zarate SS, Nehete PN, Shelton K, Nehete BP, Yang G, Dorta-Estremera S, Barnette P, Xiao P, Byrareddy SN, Villinger F, Hessell AJ, Haigwood NL, Sastry KJ, Barry MA. Divergent HIV-1-Directed Immune Responses Generated by Systemic and Mucosal Immunization with Replicating Single-Cycle Adenoviruses in Rhesus Macaques. J Virol 93(10), 2019. e-Pub 2019. PMID: 30842321.
Zhou M, Humbert M, Mukhtar MM, Scinto HB, Vyas HK, Lakhashe SK, Byrareddy SN, Maurer G, Thorat S, Owuor J, Lai Z, Chen Y, Griffiths A, Chenine AL, Gumber S, Villinger F, Montefiori D, Ruprecht RM. Adaptation of an R5 Simian-Human Immunodeficiency Virus Encoding an HIV Clade A Envelope with or without Ablation of Adaptive Host Immunity: Differential Selection of Viral Mutants. J Virol 93(9), 2019. e-Pub 2019. PMID: 30760566.
Calenda G, Frank I, Arrode-Bruses G, Pegu A, Wang K, Arthos J, Cicala C, Rogers KA, Shirreff L, Grasperge B, Blanchard JL, Maldonado S, Roberts K, Gettie A, Villinger F, Fauci AS, Mascola JR, Martinelli E. Delayed vaginal SHIV infection in VRC01 and anti-alpha4beta7 treated rhesus macaques. PLoS Pathog 15(5):e1007776, 2019. e-Pub 2019. PMID: 31083697.
Hoang T, Date AA, Ortiz JO, Young TW, Bensouda S, Xiao P, Marzinke M, Rohan L, Fuchs EJ, Hendrix C, Gumber S, Villinger F, Cone RA, Hanes J, Ensign LM. Development of rectal enema as microbicide (DREAM): Preclinical progressive selection of a tenofovir prodrug enema. Eur J Pharm Biopharm 138:23-29, 2019. e-Pub 2019. PMID: 29802984.
Lindsay KE, Bhosle SM, Zurla C, Beyersdorf J, Rogers KA, Vanover D, Xiao P, Arainga M, Shirreff LM, Pitard B, Baumhof P, Villinger F, Santangelo PJ. Visualization of early events in mRNA vaccine delivery in non-human primates via PET-CT and near-infrared imaging. Nat Biomed Eng 3(5):371-380, 2019. e-Pub 2019. PMID: 30936432.
Petitdemange C, Kasturi SP, Kozlowski PA, Nabi R, Quarnstrom CF, Reddy PBJ, Derdeyn CA, Spicer LM, Patel P, Legere T, Kovalenkov YO, Labranche CC, Villinger F, Tomai M, Vasilakos J, Haynes B, Kang CY, Gibbs JS, Yewdell JW, Barouch D, Wrammert J, Montefiori D, Hunter E, Amara RR, Masopust D, Pulendran B. Vaccine induction of antibodies and tissue-resident CD8+ T cells enhances protection against mucosal SHIV-infection in young macaques. JCI Insight 4(4), 2019. e-Pub 2019. PMID: 30830870.
Chand HS, Vazquez-Guillamet R, Royer C, Rudolph K, Mishra N, Singh SP, Hussain SS, Barrett E, Callen S, Byrareddy SN, Guillamet MCV, Abukhalaf J, Sheybani A, Exil V, Raizada V, Agarwal H, Nair M, Villinger F, Buch S, Sopori M. Cigarette smoke and HIV synergistically affect lung pathology in cynomolgus macaques. J Clin Invest 128(12):5428-5433, 2018. e-Pub 2018. PMID: 30277472.
Bhaumik SK, Kulkarni RR, Weldon WC, Silveira ELV, Ahmed H, Gunisetty S, Chandele A, Antia R, Verma H, Sutter R, Pallansch MA, Oberste MS, Villinger F, Orenstein W, Murali-Krishna K. Immune Priming and Long-term Persistence of Memory B Cells After Inactivated Poliovirus Vaccine in Macaque Models: Support for at least 2 Doses. Clin Infect Dis 67(suppl_1):S66-S77, 2018. e-Pub 2018. PMID: 30376091.
Nawaz F, Goes LR, Ray JC, Olowojesiku R, Sajani A, Ansari AA, Perrone I, Hiatt J, Van Ryk D, Wei D, Waliszewski M, Soares MA, Jelicic K, Connors M, Migueles SA, Martinelli E, Villinger F, Cicala C, Fauci AS, Arthos J. MAdCAM costimulation through Integrin-alpha(4)beta(7) promotes HIV replication. Mucosal Immunol 11(5):1342-1351, 2018. e-Pub 2018. PMID: 29875402.
Gumber S, Amancha PK, Yen PJ, Villinger F, Gabuzda D, Byrareddy SN. In vivo characterization of macrophage-tropic simian immunodeficiency virus molecular clones in rhesus macaques. J Neurovirol 24(4):411-419, 2018. e-Pub 2018. PMID: 29594984.
Lertjuthaporn S, Cicala C, Van Ryk D, Liu M, Yolitz J, Wei D, Nawaz F, Doyle A, Horowitch B, Park C, Lu S, Lou Y, Wang S, Pan R, Jiang X, Villinger F, Byrareddy SN, Santangelo PJ, Morris L, Wibmer CK, Biris K, Mason RD, Gorman J, Hiatt J, Martinelli E, Roederer M, Fujikawa D, Gorini G, Franchini G, Arakelyan A, Ansari AA, Pattanapanyasat K, Kong XP, Fauci AS, Arthos J. Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to alpha4beta7. PLoS Pathog 14(8):e1007278, 2018. e-Pub 2018. PMID: 30153309.
Dave RS, Sharma RK, Muir RR, Haddad E, Gumber S, Villinger F, Nehra AP, Khan ZK, Wigdahl B, Ansari AA, Byrareddy SN, Jain P. FDC:TFH Interactions within Cervical Lymph Nodes of SIV-Infected Rhesus Macaques. J Neuroimmune Pharmacol 13(2):204-218, 2018. e-Pub 2018. PMID: 29288344.
Santangelo PJ, Cicala C, Byrareddy SN, Ortiz KT, Little D, Lindsay KE, Gumber S, Hong JJ, Jelicic K, Rogers KA, Zurla C, Villinger F, Ansari AA, Fauci AS, Arthos J. Early treatment of SIV+ macaques with an alpha(4)beta(7) mAb alters virus distribution and preserves CD4(+) T cells in later stages of infection. Mucosal Immunol 11(3):932-946, 2018. e-Pub 2018. PMID: 29346349.
Xiao P, Gumber S, Marzinke MA, Date AA, Hoang T, Hanes J, Ensign LM, Wang L, Rohan L, Fuchs EJ, Hendrix C, Villinger F. Hypo-osmolar Formulation of Tenofovir (TFV) Enema Promotes Uptake and Metabolism of TFV in Tissues, Leading to Prevention of SHIV/SIV Infection. Antimicrob Agents Chemother 62(1), 2018. e-Pub 2018. PMID: 29084755.
Ramasamy V, Arora U, Shukla R, Poddar A, Shanmugam RK, White LJ, Mattocks MM, Raut R, Perween A, Tyagi P, de Silva AM, Bhaumik SK, Kaja MK, Villinger F, Ahmed R, Johnston RE, Swaminathan S, Khanna N. A tetravalent virus-like particle vaccine designed to display domain III of dengue envelope proteins induces multi-serotype neutralizing antibodies in mice and macaques which confer protection against antibody dependent enhancement in AG129 mice. PLoS Negl Trop Dis 12(1):e0006191, 2018. e-Pub 2018. PMID: 29309412.
Mendez-Lagares G, Lu D, Merriam D, Baker CA, Villinger F, Van Rompay KKA, McCune JM, Hartigan-O'Connor DJ. IL-21 Therapy Controls Immune Activation and Maintains Antiviral CD8(+) T Cell Responses in Acute Simian Immunodeficiency Virus Infection. AIDS Res Hum Retroviruses 33(S1):S81-S92, 2017. e-Pub 2017. PMID: 29140110.
Merriam D, Chen C, Mendez-Lagares G, Rogers KA, Michaels AJ, Yan J, Casaz P, Reimann KA, Villinger F, Hartigan-O'Connor DJ. Depletion of Gut-Resident CCR5(+) Cells for HIV Cure Strategies. AIDS Res Hum Retroviruses 33(S1):S70-S80, 2017. e-Pub 2017. PMID: 28918646.
Daggett GJ Jr, Zhao C, Connor-Stroud F, Oviedo-Moreno P, Moon H, Cho MW, Moench T, Anderson DJ, Villinger F. Comparison of the vaginal environment in rhesus and cynomolgus macaques pre- and post-lactobacillus colonization. J Med Primatol 46(5):232-238, 2017. e-Pub 2017. PMID: 28488364.
Hong JJ, Silveira ELDV, Amancha PK, Byrareddy SN, Gumber S, Chang KT, Ansari AA, Villinger F. Early initiation of antiretroviral treatment postSIV infection does not resolve lymphoid tissue activation. AIDS 31(13):1819-1824, 2017. e-Pub 2017. PMID: 28692537.
Silveira ELV, Rogers KA, Gumber S, Amancha P, Xiao P, Woollard SM, Byrareddy SN, Teixeira MM, Villinger F. Immune Cell Dynamics in Rhesus Macaques Infected with a Brazilian Strain of Zika Virus. J Immunol 199(3):1003-1011, 2017. e-Pub 2017. PMID: 28667164.
Fujino M, Sato H, Okamura T, Uda A, Takeda S, Ahmed N, Shichino S, Shiino T, Saito Y, Watanabe S, Sugimoto C, Kuroda MJ, Ato M, Nagai Y, Izumo S, Matsushima K, Miyazawa M, Ansari AA, Villinger F, Mori K. Simian Immunodeficiency Virus Targeting of CXCR3(+) CD4(+) T Cells in Secondary Lymphoid Organs Is Associated with Robust CXCL10 Expression in Monocyte/Macrophage Subsets. J Virol 91(13), 2017. e-Pub 2017. PMID: 28424283.
Zhao C, Gunawardana M, Villinger F, Baum MM, Remedios-Chan M, Moench TR, Zeitlin L, Whaley KJ, Bohorov O, Smith TJ, Anderson DJ, Moss JA. Pharmacokinetics and Preliminary Safety of Pod-Intravaginal Rings Delivering the Monoclonal Antibody VRC01-N for HIV Prophylaxis in a Macaque Model. Antimicrob Agents Chemother 61(7), 2017. e-Pub 2017. PMID: 28416548.
Kasturi SP, Kozlowski PA, Nakaya HI, Burger MC, Russo P, Pham M, Kovalenkov Y, Silveira ELV, Havenar-Daughton C, Burton SL, Kilgore KM, Johnson MJ, Nabi R, Legere T, Sher ZJ, Chen X, Amara RR, Hunter E, Bosinger SE, Spearman P, Crotty S, Villinger F, Derdeyn CA, Wrammert J, Pulendran B. Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5alpha Restrictive Macaques. J Virol 91(4), 2017. e-Pub 2017. PMID: 27928002.
Voss JE, Macauley MS, Rogers KA, Villinger F, Duan L, Shang L, Fink EA, Andrabi R, Colantonio AD, Robinson JE, Johnson RP, Burton DR, Haase AT. Reproducing SIVDeltanef vaccine correlates of protection: trimeric gp41 antibody concentrated at mucosal front lines. AIDS 30(16):2427-2438, 2016. e-Pub 2016. PMID: 27428745.
Byrareddy SN, Arthos J, Cicala C, Villinger F, Ortiz KT, Little D, Sidell N, Kane MA, Yu J, Jones JW, Santangelo PJ, Zurla C, McKinnon LR, Arnold KB, Woody CE, Walter L, Roos C, Noll A, Van Ryk D, Jelicic K, Cimbro R, Gumber S, Reid MD, Adsay V, Amancha PK, Mayne AE, Parslow TG, Fauci AS, Ansari AA. Sustained virologic control in SIV+ macaques after antiretroviral and alpha4beta7 antibody therapy. Science 354(6309):197-202, 2016. e-Pub 2016. PMID: 27738167.
Velu V, Mylvaganam GH, Gangadhara S, Hong JJ, Iyer SS, Gumber S, Ibegbu CC, Villinger F, Amara RR. Induction of Th1-Biased T Follicular Helper (Tfh) Cells in Lymphoid Tissues during Chronic Simian Immunodeficiency Virus Infection Defines Functionally Distinct Germinal Center Tfh Cells. J Immunol 197(5):1832-42, 2016. e-Pub 2016. PMID: 27481845.
Gumber S, Nascimento FS, Rogers KA, Bishop HS, Rivera HN, Xayavong MV, Devare SG, Schochetman G, Amancha PK, Qvarnstrom Y, Wilkins PP, Villinger F. Experimental transfusion-induced Babesia microti infection: dynamics of parasitemia and immune responses in a rhesus macaque model. Transfusion 56(6 Pt 2):1508-19, 2016. e-Pub 2016. PMID: 26892459.
Clark KB, Hsiao HM, Bassit L, Crowe JE Jr, Schinazi RF, Perng GC, Villinger F. Characterization of dengue virus 2 growth in megakaryocyte-erythrocyte progenitor cells. Virology 493:162-72, 2016. e-Pub 2016. PMID: 27058763.
Burghuber CK, Kwun J, Page EJ, Manook M, Gibby AC, Leopardi FV, Song M, Farris AB 3rd, Hong JJ, Villinger F, Adams AB, Iwakoshi NN, Knechtle SJ. Antibody-Mediated Rejection in Sensitized Nonhuman Primates: Modeling Human Biology. Am J Transplant 16(6):1726-38, 2016. e-Pub 2016. PMID: 26705099.
Panigrahi S, Freeman ML, Funderburg NT, Mudd JC, Younes SA, Sieg SF, Zidar DA, Paiardini M, Villinger F, Calabrese LH, Ransohoff RM, Jain MK, Lederman MM. SIV/SHIV Infection Triggers Vascular Inflammation, Diminished Expression of Kruppel-like Factor 2 and Endothelial Dysfunction. J Infect Dis 213(9):1419-27, 2016. e-Pub 2016. PMID: 26671887.
Ofotokun I, Titanji K, Vunnava A, Roser-Page S, Vikulina T, Villinger F, Rogers K, Sheth AN, Lahiri CD, Lennox JL, Weitzmann MN. Antiretroviral therapy induces a rapid increase in bone resorption that is positively associated with the magnitude of immune reconstitution in HIV infection. AIDS 30(3):405-14, 2016. e-Pub 2016. PMID: 26760232.
Konadu KA, Huang MB, Roth W, Armstrong W, Powell M, Villinger F, Bond V. Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals. J Vis Exp(107), 2016. e-Pub 2016. PMID: 26780239.
Micci L, Ryan ES, Fromentin R, Bosinger SE, Harper JL, He T, Paganini S, Easley KA, Chahroudi A, Benne C, Gumber S, McGary CS, Rogers KA, Deleage C, Lucero C, Byrareddy SN, Apetrei C, Estes JD, Lifson JD, Piatak M Jr, Chomont N, Villinger F, Silvestri G, Brenchley JM, Paiardini M. Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques. J Clin Invest 125(12):4497-513, 2015. e-Pub 2015. PMID: 26551680.
Morris MR, Byrareddy SN, Villinger F, Henning TC, Butler K, Ansari AA, McNicholl JM, Kersh EN. Relationship of menstrual cycle and vaginal infection in female rhesus macaques challenged with repeated, low doses of SIVmac251. J Med Primatol 44(5):301-5, 2015. e-Pub 2015. PMID: 26054016.
Iyer SS, Gangadhara S, Victor B, Gomez R, Basu R, Hong JJ, Labranche C, Montefiori DC, Villinger F, Moss B, Amara RR. Codelivery of Envelope Protein in Alum with MVA Vaccine Induces CXCR3-Biased CXCR5+ and CXCR5- CD4 T Cell Responses in Rhesus Macaques. J Immunol 195(3):994-1005, 2015. e-Pub 2015. PMID: 26116502.
Kilgore KM, Murphy MK, Burton SL, Wetzel KS, Smith SA, Xiao P, Reddy S, Francella N, Sodora DL, Silvestri G, Cole KS, Villinger F, Robinson JE, Pulendran B, Hunter E, Collman RG, Amara RR, Derdeyn CA. Characterization and Implementation of a Diverse Simian Immunodeficiency Virus SIVsm Envelope Panel in the Assessment of Neutralizing Antibody Breadth Elicited in Rhesus Macaques by Multimodal Vaccines Expressing the SIVmac239 Envelope. J Virol 89(16):8130-51, 2015. e-Pub 2015. PMID: 26018167.
Konadu KA, Anderson JS, Huang MB, Ali SA, Powell MD, Villinger F, Bond VC. Hallmarks of HIV-1 pathogenesis are modulated by Nef's Secretion Modification Region. J AIDS Clin Res 6(7), 2015. e-Pub 2015. PMID: 26523240.
Byrareddy SN, Sidell N, Arthos J, Cicala C, Zhao C, Little DM, Dunbar P, Yang GX, Pierzchalski K, Kane MA, Mayne AE, Song B, Soares MA, Villinger F, Fauci AS, Ansari AA. Species-specific differences in the expression and regulation of alpha4beta7 integrin in various nonhuman primates. J Immunol 194(12):5968-79, 2015. e-Pub 2015. PMID: 25948815.
Konadu KA, Chu J, Huang MB, Amancha PK, Armstrong W, Powell MD, Villinger F, Bond VC. Association of Cytokines With Exosomes in the Plasma of HIV-1-Seropositive Individuals. J Infect Dis 211(11):1712-6, 2015. e-Pub 2015. PMID: 25512626.
You H, Gobert GN, Cai P, Mou R, Nawaratna S, Fang G, Villinger F, McManus DP. Suppression of the Insulin Receptors in Adult Schistosoma japonicum Impacts on Parasite Growth and Development: Further Evidence of Vaccine Potential. PLoS Negl Trop Dis 9(5):e0003730, 2015. e-Pub 2015. PMID: 25961574.
Santangelo PJ, Rogers KA, Zurla C, Blanchard EL, Gumber S, Strait K, Connor-Stroud F, Schuster DM, Amancha PK, Hong JJ, Byrareddy SN, Hoxie JA, Vidakovic B, Ansari AA, Hunter E, Villinger F. Whole-body immunoPET reveals active SIV dynamics in viremic and antiretroviral therapy-treated macaques. Nat Methods 12(5):427-32, 2015. e-Pub 2015. PMID: 25751144.
Sholukh AM, Watkins JD, Vyas HK, Gupta S, Lakhashe SK, Thorat S, Zhou M, Hemashettar G, Bachler BC, Forthal DN, Villinger F, Sattentau QJ, Weiss RA, Agatic G, Corti D, Lanzavecchia A, Heeney JL, Ruprecht RM. Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: complete protection of rhesus monkeys from mucosal SHIV challenge. Vaccine 33(17):2086-95, 2015. e-Pub 2015. PMID: 25769884.
Kwa S, Sadagopal S, Shen X, Hong JJ, Gangadhara S, Basu R, Victor B, Iyer SS, LaBranche CC, Montefiori DC, Tomaras GD, Villinger F, Moss B, Kozlowski PA, Amara RR. CD40L-adjuvanted DNA/modified vaccinia virus Ankara simian immunodeficiency virus (SIV) vaccine enhances protection against neutralization-resistant mucosal SIV infection. J Virol 89(8):4690-5, 2015. e-Pub 2015. PMID: 25653428.
Amancha PK, Hong JJ, Ansari AA, Villinger F. Up-regulation of Tim-3 on T cells during acute simian immunodeficiency virus infection and on antigen specific responders. AIDS 29(5):531-6, 2015. e-Pub 2015. PMID: 25715103.
Kwun J, Page E, Hong JJ, Gibby A, Yoon J, Farris AB, Villinger F, Knechtle S. Neutralizing BAFF/APRIL with atacicept prevents early DSA formation and AMR development in T cell depletion induced nonhuman primate AMR model. Am J Transplant 15(3):815-22, 2015. e-Pub 2015. PMID: 25675879.
Courtney CL, Ethun KF, Villinger F, Ruprecht RM, Byrareddy SN. Massive occlusive thrombosis of the pulmonary artery in pigtailed macaques chronically infected with R5-tropic simian-human immunodeficiency virus. J Med Primatol 44(1):35-9, 2015. e-Pub 2015. PMID: 25174584.
Silveira EL, Kasturi SP, Kovalenkov Y, Rasheed AU, Yeiser P, Jinnah ZS, Legere TH, Pulendran B, Villinger F, Wrammert J. Vaccine-induced plasmablast responses in rhesus macaques: phenotypic characterization and a source for generating antigen-specific monoclonal antibodies. J Immunol Methods 416:69-83, 2015. e-Pub 2015. PMID: 25445326.
Byrareddy SN, Little D, Mayne AE, Villinger F, Ansari AA. Phenotypic and Functional Characterization of Monoclonal Antibodies with Specificity for Rhesus Macaque CD200, CD200R and Mincle. PLoS One 10(10):e0140689, 2015. e-Pub 2015. PMID: 26468886.
Gumber S, Nusrat A, Villinger F. Immunohistological characterization of intercellular junction proteins in rhesus macaque intestine. Exp Toxicol Pathol 66(9-10):437-44, 2014. e-Pub 2014. PMID: 25153024.
Byrareddy SN, Kallam B, Arthos J, Cicala C, Nawaz F, Hiatt J, Kersh EN, McNicholl JM, Hanson D, Reimann KA, Brameier M, Walter L, Rogers K, Mayne AE, Dunbar P, Villinger T, Little D, Parslow TG, Santangelo PJ, Villinger F, Fauci AS, Ansari AA. Targeting alpha4beta7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection. Nat Med 20(12):1397-400, 2014. e-Pub 2014. PMID: 25419708.
Lakhashe SK, Byrareddy SN, Zhou M, Bachler BC, Hemashettar G, Hu SL, Villinger F, Else JG, Stock S, Lee SJ, Vargas-Inchaustegui DA, Cofano EB, Robert-Guroff M, Johnson WE, Polonis VR, Forthal DN, Loret EP, Rasmussen RA, Ruprecht RM. Multimodality vaccination against clade C SHIV: partial protection against mucosal challenges with a heterologous tier 2 virus. Vaccine 32(48):6527-36, 2014. e-Pub 2014. PMID: 25245933.
Mylvaganam GH, Velu V, Hong JJ, Sadagopal S, Kwa S, Basu R, Lawson B, Villinger F, Amara RR. Diminished viral control during simian immunodeficiency virus infection is associated with aberrant PD-1hi CD4 T cell enrichment in the lymphoid follicles of the rectal mucosa. J Immunol 193(9):4527-36, 2014. e-Pub 2014. PMID: 25246494.
Hong JJ, Villinger F, Courtney CL. PAS-positive extracellular deposits within germinal centers of hyperplastic follicles during SIV infection in a rhesus macaque. J Med Primatol 43(5):374-7, 2014. e-Pub 2014. PMID: 24628065.
Hong JJ, Amancha PK, Rogers KA, Courtney CL, Havenar-Daughton C, Crotty S, Ansari AA, Villinger F. Early lymphoid responses and germinal center formation correlate with lower viral load set points and better prognosis of simian immunodeficiency virus infection. J Immunol 193(2):797-806, 2014. e-Pub 2014. PMID: 24907346.
Kwissa M, Nakaya HI, Onlamoon N, Wrammert J, Villinger F, Perng GC, Yoksan S, Pattanapanyasat K, Chokephaibulkit K, Ahmed R, Pulendran B. Dengue virus infection induces expansion of a CD14(+)CD16(+) monocyte population that stimulates plasmablast differentiation. Cell Host Microbe 16(1):115-27, 2014. e-Pub 2014. PMID: 24981333.
Jacquelin B, Petitjean G, Kunkel D, Liovat AS, Jochems SP, Rogers KA, Ploquin MJ, Madec Y, Barre-Sinoussi F, Dereuddre-Bosquet N, Lebon P, Le Grand R, Villinger F, Muller-Trutwin M. Innate immune responses and rapid control of inflammation in African green monkeys treated or not with interferon-alpha during primary SIVagm infection. PLoS Pathog 10(7):e1004241, 2014. e-Pub 2014. PMID: 24991927.
Leskowitz R, Fogg MH, Zhou XY, Kaur A, Silveira EL, Villinger F, Lieberman PM, Wang F, Ertl HC. Adenovirus-based vaccines against rhesus lymphocryptovirus EBNA-1 induce expansion of specific CD8+ and CD4+ T cells in persistently infected rhesus macaques. J Virol 88(9):4721-35, 2014. e-Pub 2014. PMID: 24522914.
Sharma P, Chennareddi L, Greene-Hartsfield EZ, Villinger F, Cohen JK, Herndon JG. Hematology and serum chemistry values of sooty mangabeys (Cercocebus atys): comparison with rhesus monkeys. J Med Primatol 43(2):78-88, 2014. e-Pub 2014. PMID: 24256341.
Chan AW, Xu Y, Jiang J, Rahim T, Zhao D, Kocerha J, Chi T, Moran S, Engelhardt H, Larkin K, Neumann A, Cheng H, Li C, Nelson K, Banta H, Zola SM, Villinger F, Yang J, Testa CM, Mao H, Zhang X, Bachevalier J. A two years longitudinal study of a transgenic Huntington disease monkey. BMC Neurosci 15:36, 2014. e-Pub 2014. PMID: 24581271.
Takahashi Y, Byrareddy SN, Albrecht C, Brameier M, Walter L, Mayne AE, Dunbar P, Russo R, Little DM, Villinger T, Khowawisetsut L, Pattanapanyasat K, Villinger F, Ansari AA. In vivo administration of a JAK3 inhibitor during acute SIV infection leads to significant increases in viral load during chronic infection. PLoS Pathog 10(3):e1003929, 2014. e-Pub 2014. PMID: 24603870.
Chahroudi A, Cartwright E, Lee ST, Mavigner M, Carnathan DG, Lawson B, Carnathan PM, Hashempoor T, Murphy MK, Meeker T, Ehnert S, Souder C, Else JG, Cohen J, Collman RG, Vanderford TH, Permar SR, Derdeyn CA, Villinger F, Silvestri G. Target cell availability, rather than breast milk factors, dictates mother-to-infant transmission of SIV in sooty mangabeys and rhesus macaques. PLoS Pathog 10(3):e1003958, 2014. e-Pub 2014. PMID: 24604066.
Sholukh AM, Byrareddy SN, Shanmuganathan V, Hemashettar G, Lakhashe SK, Rasmussen RA, Watkins JD, Vyas HK, Thorat S, Brandstoetter T, Mukhtar MM, Yoon JK, Novembre FJ, Villinger F, Landucci G, Forthal DN, Ratcliffe S, Tuero I, Robert-Guroff M, Polonis VR, Bilska M, Montefiori DC, Johnson WE, Ertl HC, Ruprecht RM. Passive immunization of macaques with polyclonal anti-SHIV IgG against a heterologous tier 2 SHIV: outcome depends on IgG dose. Retrovirology 11:8, 2014. e-Pub 2014. PMID: 24444350.
Kim EJ, Kwun J, Gibby AC, Hong JJ, Farris AB 3rd, Iwakoshi NN, Villinger F, Kirk AD, Knechtle SJ. Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection. Am J Transplant 14(1):59-69, 2014. e-Pub 2014. PMID: 24354871.
Tieu R, Amancha PK, Villinger F, Byrareddy SN. TIM-3, a Possible Target for Immunotherapy in Cancer and Chronic Viral Infections. Austin Virol Retro Virol 1(2), 2014. e-Pub 2014. PMID: 26539564.
Arrode-Bruses G, Moussa M, Baccard-Longere M, Villinger F, Chebloune Y. Long-term central and effector SHIV-specific memory T cell responses elicited after a single immunization with a novel lentivector DNA vaccine. PLoS One 9(10):e110883, 2014. e-Pub 2014. PMID: 25337803.
Amancha PK, Hong JJ, Rogers K, Ansari AA, Villinger F. In vivo blockade of the programmed cell death-1 pathway using soluble recombinant PD-1-Fc enhances CD4+ and CD8+ T cell responses but has limited clinical benefit. J Immunol 191(12):6060-70, 2013. e-Pub 2013. PMID: 24227774.
Weber CJ, Muller S, Safley SA, Gordon KB, Amancha P, Villinger F, Camp VM, Lipowska M, Sharma J, Muller C, Schibli R, Low PS, Leamon CP, Halkar RK. Expression of functional folate receptors by human parathyroid cells. Surgery 154(6):1385-93; discussion 1393, 2013. e-Pub 2013. PMID: 24206618.
Silveira EL, Fogg MH, Leskowitz RM, Ertl HC, Wiseman RW, O'Connor DH, Lieberman P, Wang F, Villinger F. Therapeutic vaccination against the rhesus lymphocryptovirus EBNA-1 homologue, rhEBNA-1, elicits T cell responses to novel epitopes in rhesus macaques. J Virol 87(24):13904-10, 2013. e-Pub 2013. PMID: 24089556.
Leskowitz RM, Zhou XY, Villinger F, Fogg MH, Kaur A, Lieberman PM, Wang F, Ertl HC. CD4+ and CD8+ T-cell responses to latent antigen EBNA-1 and lytic antigen BZLF-1 during persistent lymphocryptovirus infection of rhesus macaques. J Virol 87(15):8351-62, 2013. e-Pub 2013. PMID: 23698300.
Watkins JD, Sholukh AM, Mukhtar MM, Siddappa NB, Lakhashe SK, Kim M, Reinherz EL, Gupta S, Forthal DN, Sattentau QJ, Villinger F, Corti D, Ruprecht RM. Anti-HIV IgA isotypes: differential virion capture and inhibition of transcytosis are linked to prevention of mucosal R5 SHIV transmission. AIDS 27(9):F13-20, 2013. e-Pub 2013. PMID: 23775002.
Pallikkuth S, Micci L, Ende ZS, Iriele RI, Cervasi B, Lawson B, McGary CS, Rogers KA, Else JG, Silvestri G, Easley K, Estes JD, Villinger F, Pahwa S, Paiardini M. Maintenance of intestinal Th17 cells and reduced microbial translocation in SIV-infected rhesus macaques treated with interleukin (IL)-21. PLoS Pathog 9(7):e1003471, 2013. e-Pub 2013. PMID: 23853592.
Hong JJ, Amancha PK, Rogers K, Ansari AA, Villinger F. Re-evaluation of PD-1 expression by T cells as a marker for immune exhaustion during SIV infection. PLoS One 8(3):e60186, 2013. e-Pub 2013. PMID: 23555918.
Byrareddy SN, Ayash-Rashkovsky M, Kramer VG, Lee SJ, Correll M, Novembre FJ, Villinger F, Johnson WE, von Gegerfelt A, Felber BK, Ruprecht RM. Live attenuated Rev-independent Nef SIV enhances acquisition of heterologous SIVsmE660 in acutely vaccinated rhesus macaques. PLoS One 8(9):e75556, 2013. e-Pub 2013. PMID: 24098702.
Takahashi Y, Mayne AE, Khowawisetsut L, Pattanapanyasat K, Little D, Villinger F, Ansari AA. In vivo administration of a JAK3 inhibitor to chronically siv infected rhesus macaques leads to NK cell depletion associated with transient modest increase in viral loads. PLoS One 8(7):e70992, 2013. e-Pub 2013. PMID: 23923040.
Khowawisetsut L, Pattanapanyasat K, Onlamoon N, Mayne AE, Little DM, Villinger F, Ansari AA. Relationships between IL-17(+) subsets, Tregs and pDCs that distinguish among SIV infected elite controllers, low, medium and high viral load rhesus macaques. PLoS One 8(4):e61264, 2013. e-Pub 2013. PMID: 23620737.
Micci L, Cervasi B, Ende ZS, Iriele RI, Reyes-Aviles E, Vinton C, Else J, Silvestri G, Ansari AA, Villinger F, Pahwa S, Estes JD, Brenchley JM, Paiardini M. Paucity of IL-21-producing CD4(+) T cells is associated with Th17 cell depletion in SIV infection of rhesus macaques. Blood 120(19):3925-35, 2012. e-Pub 2012. PMID: 22990011.
Noisakran S, Onlamoon N, Pattanapanyasat K, Hsiao HM, Songprakhon P, Angkasekwinai N, Chokephaibulkit K, Villinger F, Ansari AA, Perng GC. Role of CD61+ cells in thrombocytopenia of dengue patients. Int J Hematol 96(5):600-10, 2012. e-Pub 2012. PMID: 22987294.
Sugimoto C, Nakamura S, Hagen SI, Tsunetsugu-Yokota Y, Villinger F, Ansari AA, Suzuki Y, Yamamoto N, Nagai Y, Picker LJ, Mori K. Glycosylation of simian immunodeficiency virus influences immune-tissue targeting during primary infection, leading to immunodeficiency or viral control. J Virol 86(17):9323-36, 2012. e-Pub 2012. PMID: 22718828.
Vanderford TH, Slichter C, Rogers KA, Lawson BO, Obaede R, Else J, Villinger F, Bosinger SE, Silvestri G. Treatment of SIV-infected sooty mangabeys with a type-I IFN agonist results in decreased virus replication without inducing hyperimmune activation. Blood 119(24):5750-7, 2012. e-Pub 2012. PMID: 22550346.
Hong JJ, Amancha PK, Rogers K, Ansari AA, Villinger F. Spatial alterations between CD4(+) T follicular helper, B, and CD8(+) T cells during simian immunodeficiency virus infection: T/B cell homeostasis, activation, and potential mechanism for viral escape. J Immunol 188(7):3247-56, 2012. e-Pub 2012. PMID: 22387550.
Noisakran S, Onlamoon N, Hsiao HM, Clark KB, Villinger F, Ansari AA, Perng GC. Infection of bone marrow cells by dengue virus in vivo. Exp Hematol 40(3):250-259.e4, 2012. e-Pub 2012. PMID: 22193689.
Rasmussen RA, Siddappa NB, Lakhashe SK, Watkins J, Villinger F, Ibegbu C, Florese RH, Robert-Guroff M, Montefiori DC, Forthal DN, O'Connor D, Ruprecht RM. High-level, lasting antiviral immunity induced by a bimodal AIDS vaccine and boosted by live-virus exposure: prevention of viremia. AIDS 26(2):149-55, 2012. e-Pub 2012. PMID: 21941166.
Clark KB, Noisakran S, Onlamoon N, Hsiao HM, Roback J, Villinger F, Ansari AA, Perng GC. Multiploid CD61+ cells are the pre-dominant cell lineage infected during acute dengue virus infection in bone marrow. PLoS One 7(12):e52902, 2012. e-Pub 2012. PMID: 23300812.
Zhang A, Bogerd H, Villinger F, Das Gupta J, Dong B, Klein EA, Hackett J Jr, Schochetman G, Cullen BR, Silverman RH. In vivo hypermutation of xenotropic murine leukemia virus-related virus DNA in peripheral blood mononuclear cells of rhesus macaque by APOBEC3 proteins. Virology 421(1):28-33, 2011. e-Pub 2011. PMID: 21982221.
Pallikkuth S, Rogers K, Villinger F, Dosterii M, Vaccari M, Franchini G, Pahwa R, Pahwa S. Interleukin-21 administration to rhesus macaques chronically infected with simian immunodeficiency virus increases cytotoxic effector molecules in T cells and NK cells and enhances B cell function without increasing immune activation or viral replication. Vaccine 29(49):9229-38, 2011. e-Pub 2011. PMID: 21996099.
Lugli E, Mueller YM, Lewis MG, Villinger F, Katsikis PD, Roederer M. IL-15 delays suppression and fails to promote immune reconstitution in virally suppressed chronically SIV-infected macaques. Blood 118(9):2520-9, 2011. e-Pub 2011. PMID: 21757617.
Lakhashe SK, Velu V, Sciaranghella G, Siddappa NB, Dipasquale JM, Hemashettar G, Yoon JK, Rasmussen RA, Yang F, Lee SJ, Montefiori DC, Novembre FJ, Villinger F, Amara RR, Kahn M, Hu SL, Li S, Li Z, Frankel FR, Robert-Guroff M, Johnson WE, Lieberman J, Ruprecht RM. Prime-boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: efficacy against repeated mucosal R5 clade C SHIV challenges. Vaccine 29(34):5611-22, 2011. e-Pub 2011. PMID: 21693155.
Lai L, Kwa S, Kozlowski PA, Montefiori DC, Ferrari G, Johnson WE, Hirsch V, Villinger F, Chennareddi L, Earl PL, Moss B, Amara RR, Robinson HL. Prevention of infection by a granulocyte-macrophage colony-stimulating factor co-expressing DNA/modified vaccinia Ankara simian immunodeficiency virus vaccine. J Infect Dis 204(1):164-73, 2011. e-Pub 2011. PMID: 21628671.
Onlamoon N, Das Gupta J, Sharma P, Rogers K, Suppiah S, Rhea J, Molinaro RJ, Gaughan C, Dong B, Klein EA, Qiu X, Devare S, Schochetman G, Hackett J Jr, Silverman RH, Villinger F. Infection, viral dissemination, and antibody responses of rhesus macaques exposed to the human gammaretrovirus XMRV. J Virol 85(9):4547-57, 2011. e-Pub 2011. PMID: 21325416.
Siddappa NB, Hemashettar G, Wong YL, Lakhashe S, Rasmussen RA, Watkins JD, Novembre FJ, Villinger F, Else JG, Montefiori DC, Ruprecht RM. Development of a tier 1 R5 clade C simian-human immunodeficiency virus as a tool to test neutralizing antibody-based immunoprophylaxis. J Med Primatol 40(2):120-8, 2011. e-Pub 2011. PMID: 21044092.
Watkins JD, Siddappa NB, Lakhashe SK, Humbert M, Sholukh A, Hemashettar G, Wong YL, Yoon JK, Wang W, Novembre FJ, Villinger F, Ibegbu C, Patel K, Corti D, Agatic G, Vanzetta F, Bianchi S, Heeney JL, Sallusto F, Lanzavecchia A, Ruprecht RM. An anti-HIV-1 V3 loop antibody fully protects cross-clade and elicits T-cell immunity in macaques mucosally challenged with an R5 clade C SHIV. PLoS One 6(3):e18207, 2011. e-Pub 2011. PMID: 21483815.
Kasturi SP, Skountzou I, Albrecht RA, Koutsonanos D, Hua T, Nakaya HI, Ravindran R, Stewart S, Alam M, Kwissa M, Villinger F, Murthy N, Steel J, Jacob J, Hogan RJ, Garcia-Sastre A, Compans R, Pulendran B. Programming the magnitude and persistence of antibody responses with innate immunity. Nature 470(7335):543-7, 2011. e-Pub 2011. PMID: 21350488.
Ansari AA, Reimann KA, Mayne AE, Takahashi Y, Stephenson ST, Wang R, Wang X, Li J, Price AA, Little DM, Zaidi M, Lyles R, Villinger F. Blocking of alpha4beta7 gut-homing integrin during acute infection leads to decreased plasma and gastrointestinal tissue viral loads in simian immunodeficiency virus-infected rhesus macaques. J Immunol 186(2):1044-59, 2011. e-Pub 2011. PMID: 21149598.
Lakhashe SK, Wang W, Siddappa NB, Hemashettar G, Polacino P, Hu SL, Villinger F, Else JG, Novembre FJ, Yoon JK, Lee SJ, Montefiori DC, Ruprecht RM, Rasmussen RA. Vaccination against heterologous R5 clade C SHIV: prevention of infection and correlates of protection. PLoS One 6(7):e22010, 2011. e-Pub 2011. PMID: 21799765.
Sharma P, Rogers KA, Suppiah S, Molinaro RJ, Onlamoon N, Hackett J Jr, Schochetman G, Klein EA, Silverman RH, Villinger F. Sexual Transmission of XMRV: A Potential Infection Route. Adv Virol 2011:965689, 2011. e-Pub 2011. PMID: 22312360.
Garcia A, Siddappa NB, Li Q, Haase AT, Paul K, Stroud F, Zhang X, Fountain JA, Villinger F, Novembre FJ, Else JG, Evan Secor W, Ruprecht RM. AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4. J Med Primatol 39(5):356-60, 2010. e-Pub 2010. PMID: 20412378.
Villinger F, Ansari AA. Role of IL-12 in HIV infection and vaccine. Eur Cytokine Netw 21(3):215-8, 2010. e-Pub 2010. PMID: 20719709.
Qiu X, Swanson P, Luk KC, Tu B, Villinger F, Das Gupta J, Silverman RH, Klein EA, Devare S, Schochetman G, Hackett J Jr. Characterization of antibodies elicited by XMRV infection and development of immunoassays useful for epidemiologic studies. Retrovirology 7:68, 2010. e-Pub 2010. PMID: 20716359.
Leone A, Rohankhedkar M, Okoye A, Legasse A, Axthelm MK, Villinger F, Piatak M Jr, Lifson JD, Assouline B, Morre M, Picker LJ, Sodora DL. Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses. J Immunol 185(3):1650-9, 2010. e-Pub 2010. PMID: 20622118.
Siddappa NB, Watkins JD, Wassermann KJ, Song R, Wang W, Kramer VG, Lakhashe S, Santosuosso M, Poznansky MC, Novembre FJ, Villinger F, Else JG, Montefiori DC, Rasmussen RA, Ruprecht RM. R5 clade C SHIV strains with tier 1 or 2 neutralization sensitivity: tools to dissect env evolution and to develop AIDS vaccines in primate models. PLoS One 5(7):e11689, 2010. e-Pub 2010. PMID: 20657739.
Sugimoto C, Watanabe S, Naruse T, Kajiwara E, Shiino T, Umano N, Ueda K, Sato H, Ohgimoto S, Hirsch V, Villinger F, Ansari AA, Kimura A, Miyazawa M, Suzuki Y, Yamamoto N, Nagai Y, Mori K. Protection of macaques with diverse MHC genotypes against a heterologous SIV by vaccination with a deglycosylated live-attenuated SIV. PLoS One 5(7):e11678, 2010. e-Pub 2010. PMID: 20652030.
Chenine AL, Siddappa NB, Kramer VG, Sciaranghella G, Rasmussen RA, Lee SJ, Santosuosso M, Poznansky MC, Velu V, Amara RR, Souder C, Anderson DC, Villinger F, Else JG, Novembre FJ, Strobert E, O'Neil SP, Secor WE, Ruprecht RM. Relative transmissibility of an R5 clade C simian-human immunodeficiency virus across different mucosae in macaques parallels the relative risks of sexual HIV-1 transmission in humans via different routes. J Infect Dis 201(8):1155-63, 2010. e-Pub 2010. PMID: 20214475.
Onlamoon N, Noisakran S, Hsiao HM, Duncan A, Villinger F, Ansari AA, Perng GC. Dengue virus-induced hemorrhage in a nonhuman primate model. Blood 115(9):1823-34, 2010. e-Pub 2010. PMID: 20042723.
Ali SA, Huang MB, Campbell PE, Roth WW, Campbell T, Khan M, Newman G, Villinger F, Powell MD, Bond VC. Genetic characterization of HIV type 1 Nef-induced vesicle secretion. AIDS Res Hum Retroviruses 26(2):173-92, 2010. e-Pub 2010. PMID: 20156100.
Arrode-Bruses G, Sheffer D, Hegde R, Dhillon S, Liu Z, Villinger F, Narayan O, Chebloune Y. Characterization of T-cell responses in macaques immunized with a single dose of HIV DNA vaccine. J Virol 84(3):1243-53, 2010. e-Pub 2010. PMID: 19923181.
Ali Z, Yan L, Plagman N, Reichenberg A, Hintz M, Jomaa H, Villinger F, Chen ZW. Gammadelta T cell immune manipulation during chronic phase of simian-human immunodeficiency virus infection [corrected] confers immunological benefits. J Immunol 183(8):5407-17, 2009. e-Pub 2009. PMID: 19786533.
Noisakran S, Chokephaibulkit K, Songprakhon P, Onlamoon N, Hsiao HM, Villinger F, Ansari A, Perng GC. A re-evaluation of the mechanisms leading to dengue hemorrhagic fever. Ann N Y Acad Sci 1171 Suppl 1:E24-35, 2009. e-Pub 2009. PMID: 19751399.
Okoye A, Park H, Rohankhedkar M, Coyne-Johnson L, Lum R, Walker JM, Planer SL, Legasse AW, Sylwester AW, Piatak M Jr, Lifson JD, Sodora DL, Villinger F, Axthelm MK, Schmitz JE, Picker LJ. Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis. J Exp Med 206(7):1575-88, 2009. e-Pub 2009. PMID: 19546246.
Zhao J, Lai L, Amara RR, Montefiori DC, Villinger F, Chennareddi L, Wyatt LS, Moss B, Robinson HL. Preclinical studies of human immunodeficiency virus/AIDS vaccines: inverse correlation between avidity of anti-Env antibodies and peak postchallenge viremia. J Virol 83(9):4102-11, 2009. e-Pub 2009. PMID: 19224993.
Dubie RA, Maksaereekul S, Shacklett BL, Lemongello D, Cole KS, Villinger F, Blozis SA, Luciw PA, Sparger EE. Co-immunization with IL-15 enhances cellular immune responses induced by a vif-deleted simian immunodeficiency virus proviral DNA vaccine and confers partial protection against vaginal challenge with SIVmac251. Virology 386(1):109-21, 2009. e-Pub 2009. PMID: 19193388.
Bostik P, Kobkitjaroen J, Tang W, Villinger F, Pereira LE, Little DM, Stephenson ST, Bouzyk M, Ansari AA. Decreased NK cell frequency and function is associated with increased risk of KIR3DL allele polymorphism in simian immunodeficiency virus-infected rhesus macaques with high viral loads. J Immunol 182(6):3638-49, 2009. e-Pub 2009. PMID: 19265142.
Eberly MD, Kader M, Hassan W, Rogers KA, Zhou J, Mueller YM, Mattapallil MJ, Piatak M Jr, Lifson JD, Katsikis PD, Roederer M, Villinger F, Mattapallil JJ. Increased IL-15 production is associated with higher susceptibility of memory CD4 T cells to simian immunodeficiency virus during acute infection. J Immunol 182(3):1439-48, 2009. e-Pub 2009. PMID: 19155491.
Pereira LE, Onlamoon N, Wang X, Wang R, Li J, Reimann KA, Villinger F, Pattanapanyasat K, Mori K, Ansari AA. Preliminary in vivo efficacy studies of a recombinant rhesus anti-alpha(4)beta(7) monoclonal antibody. Cell Immunol 259(2):165-76, 2009. e-Pub 2009. PMID: 19616201.
Zahn RC, Hermann FG, Kim EY, Rett MD, Wolinsky SM, Johnson RP, Villinger F, von Laer D, Schmitz JE. Efficient entry inhibition of human and nonhuman primate immunodeficiency virus by cell surface-expressed gp41-derived peptides. Gene Ther 15(17):1210-22, 2008. e-Pub 2008. PMID: 18449216.
Onlamoon N, Rogers K, Mayne AE, Pattanapanyasat K, Mori K, Villinger F, Ansari AA. Soluble PD-1 rescues the proliferative response of simian immunodeficiency virus-specific CD4 and CD8 T cells during chronic infection. Immunology 124(2):277-93, 2008. e-Pub 2008. PMID: 18266718.
Kitabwalla M, Ansari AA, Villinger F, Akeefe H, Conner AP, Mayne AE, Hildreth JE. Delipidated retroviruses as potential autologous therapeutic vaccines--a pilot experiment. Exp Biol Med (Maywood) 233(6):732-40, 2008. e-Pub 2008. PMID: 18408147.
Klatt NR, Villinger F, Bostik P, Gordon SN, Pereira L, Engram JC, Mayne A, Dunham RM, Lawson B, Ratcliffe SJ, Sodora DL, Else J, Reimann K, Staprans SI, Haase AT, Estes JD, Silvestri G, Ansari AA. Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys. J Clin Invest 118(6):2039-49, 2008. e-Pub 2008. PMID: 18497876.
Juompan LY, Hutchinson K, Montefiori DC, Nidtha S, Villinger F, Novembre FJ. Analysis of the immune responses in chimpanzees infected with HIV type 1 isolates. AIDS Res Hum Retroviruses 24(4):573-86, 2008. e-Pub 2008. PMID: 18426337.
Sugimoto C, Nakayama EE, Shioda T, Villinger F, Ansari AA, Yamamoto N, Suzuki Y, Nagai Y, Mori K. Impact of glycosylation on antigenicity of simian immunodeficiency virus SIV239: induction of rapid V1/V2-specific non-neutralizing antibody and delayed neutralizing antibody following infection with an attenuated deglycosylated mutant. J Gen Virol 89(Pt 2):554-566, 2008. e-Pub 2008. PMID: 18198387.
Mueller YM, Do DH, Altork SR, Artlett CM, Gracely EJ, Katsetos CD, Legido A, Villinger F, Altman JD, Brown CR, Lewis MG, Katsikis PD. IL-15 treatment during acute simian immunodeficiency virus (SIV) infection increases viral set point and accelerates disease progression despite the induction of stronger SIV-specific CD8+ T cell responses. J Immunol 180(1):350-60, 2008. e-Pub 2008. PMID: 18097036.
Lai L, Vodros D, Kozlowski PA, Montefiori DC, Wilson RL, Akerstrom VL, Chennareddi L, Yu T, Kannanganat S, Ofielu L, Villinger F, Wyatt LS, Moss B, Amara RR, Robinson HL. GM-CSF DNA: an adjuvant for higher avidity IgG, rectal IgA, and increased protection against the acute phase of a SHIV-89.6P challenge by a DNA/MVA immunodeficiency virus vaccine. Virology 369(1):153-67, 2007. e-Pub 2007. PMID: 17698160.
Pereira LE, Villinger F, Wulff H, Sankaranarayanan A, Raman G, Ansari AA. Pharmacokinetics, toxicity, and functional studies of the selective Kv1.3 channel blocker 5-(4-phenoxybutoxy)psoralen in rhesus macaques. Exp Biol Med (Maywood) 232(10):1338-54, 2007. e-Pub 2007. PMID: 17959847.
Jaroenpool J, Rogers KA, Pattanapanyasat K, Villinger F, Onlamoon N, Crocker PR, Ansari AA. Differences in the constitutive and SIV infection induced expression of Siglecs by hematopoietic cells from non-human primates. Cell Immunol 250(1-2):91-104, 2007. e-Pub 2007. PMID: 18331725.
Kwissa M, Amara RR, Robinson HL, Moss B, Alkan S, Jabbar A, Villinger F, Pulendran B. Adjuvanting a DNA vaccine with a TLR9 ligand plus Flt3 ligand results in enhanced cellular immunity against the simian immunodeficiency virus. J Exp Med 204(11):2733-46, 2007. e-Pub 2007. PMID: 17954572.
Onlamoon N, Plagman N, Rogers KA, Mayne AE, Bostik P, Pattanapanyasat K, Ansari AA, Villinger F. Anti-CD3/28 mediated expansion of macaque CD4+ T cells is polyclonal and provides extended survival after adoptive transfer. J Med Primatol 36(4-5):206-18, 2007. e-Pub 2007. PMID: 17669209.
Bostik P, Noble ES, Stephenson ST, Villinger F, Ansari AA. CD4+ T cells from simian immunodeficiency virus disease-resistant sooty mangabeys produce more IL-2 than cells from disease-susceptible species: involvement of p300 and CREB at the proximal IL-2 promoter in IL-2 up-regulation. J Immunol 178(12):7720-9, 2007. e-Pub 2007. PMID: 17548609.
Velu V, Kannanganat S, Ibegbu C, Chennareddi L, Villinger F, Freeman GJ, Ahmed R, Amara RR. Elevated expression levels of inhibitory receptor programmed death 1 on simian immunodeficiency virus-specific CD8 T cells during chronic infection but not after vaccination. J Virol 81(11):5819-28, 2007. e-Pub 2007. PMID: 17376899.
Pereira LE, Villinger F, Onlamoon N, Bryan P, Cardona A, Pattanapanysat K, Mori K, Hagen S, Picker L, Ansari AA. Simian immunodeficiency virus (SIV) infection influences the level and function of regulatory T cells in SIV-infected rhesus macaques but not SIV-infected sooty mangabeys. J Virol 81(9):4445-56, 2007. e-Pub 2007. PMID: 17314162.
Hryniewicz A, Price DA, Moniuszko M, Boasso A, Edghill-Spano Y, West SM, Venzon D, Vaccari M, Tsai WP, Tryniszewska E, Nacsa J, Villinger F, Ansari AA, Trindade CJ, Morre M, Brooks D, Arlen P, Brown HJ, Kitchen CM, Zack JA, Douek DC, Shearer GM, Lewis MG, Koup RA, Franchini G. Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus mac251-infected macaques. J Immunol 178(6):3492-504, 2007. e-Pub 2007. PMID: 17339444.
Bostik P, Noble ES, Villinger F, Ansari AA. Pathogenic and apathogenic courses of SIV infection are associated with distinct and characteristic regulatory patterns of G1/S and G2/M cell cycle checkpoints in CD4+ T cells. AIDS Res Hum Retroviruses 22(11):1122-30, 2006. e-Pub 2006. PMID: 17147499.
Stone GW, Barzee S, Snarsky V, Spina CA, Lifson JD, Pillai VK, Amara RR, Villinger F, Kornbluth RS. Macaque multimeric soluble CD40 ligand and GITR ligand constructs are immunostimulatory molecules in vitro. Clin Vaccine Immunol 13(11):1223-30, 2006. e-Pub 2006. PMID: 16988005.
Robinson HL, Montefiori DC, Villinger F, Robinson JE, Sharma S, Wyatt LS, Earl PL, McClure HM, Moss B, Amara RR. Studies on GM-CSF DNA as an adjuvant for neutralizing Ab elicited by a DNA/MVA immunodeficiency virus vaccine. Virology 352(2):285-94, 2006. e-Pub 2006. PMID: 16740288.
Onlamoon N, Hudson K, Bryan P, Mayne AE, Bonyhadi M, Berenson R, Sundstrom BJ, Bostik P, Ansari AA, Villinger F. Optimization of in vitro expansion of macaque CD4 T cells using anti-CD3 and co-stimulation for autotransfusion therapy. J Med Primatol 35(4-5):178-93, 2006. e-Pub 2006. PMID: 16872281.
Picker LJ, Reed-Inderbitzin EF, Hagen SI, Edgar JB, Hansen SG, Legasse A, Planer S, Piatak M Jr, Lifson JD, Maino VC, Axthelm MK, Villinger F. IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates. J Clin Invest 116(6):1514-24, 2006. e-Pub 2006. PMID: 16691294.
Dhillon NK, Dhillon S, Chebloune Y, Pinson D, Villinger F, Kumar A, Narayan O, Buch S. Therapy of "SHIV" infected macaques with liposomes delivering antisense interleukin-4 DNA. AIDS 20(8):1125-30, 2006. e-Pub 2006. PMID: 16691063.
Bostik P, Noble ES, Mayne AE, Gargano L, Villinger F, Ansari AA. Central memory CD4 T cells are the predominant cell subset resistant to anergy in SIV disease resistant sooty mangabeys. AIDS 20(2):181-8, 2006. e-Pub 2006. PMID: 16511410.
Amara RR, Ibegbu C, Villinger F, Montefiori DC, Sharma S, Nigam P, Xu Y, McClure HM, Robinson HL. Studies using a viral challenge and CD8 T cell depletions on the roles of cellular and humoral immunity in the control of an SHIV-89.6P challenge in DNA/MVA-vaccinated macaques. Virology 343(2):246-55, 2005. e-Pub 2005. PMID: 16185742.
Kitabwalla M, Villinger F, Akeefe H, Liao Z, Mayne AE, Gargano L, Conner AP, Maltais JA, Kunas G, Hildreth JE, Ansari AA, Bellotti M. Enhancement of cell mediated immune responses using lipid depleted lentivirus as immunogen: a novel approach for inducing recognition of new viral epitopes. Vaccine 23(38):4666-77, 2005. e-Pub 2005. PMID: 15955600.
Dhillon NK, Sui Y, Potula R, Dhillon S, Adany I, Li Z, Villinger F, Pinson D, Narayan O, Buch S. Inhibition of pathogenic SHIV replication in macaques treated with antisense DNA of interleukin-4. Blood 105(8):3094-9, 2005. e-Pub 2005. PMID: 15618469.
Mueller YM, Petrovas C, Bojczuk PM, Dimitriou ID, Beer B, Silvera P, Villinger F, Cairns JS, Gracely EJ, Lewis MG, Katsikis PD. Interleukin-15 increases effector memory CD8+ t cells and NK Cells in simian immunodeficiency virus-infected macaques. J Virol 79(8):4877-85, 2005. e-Pub 2005. PMID: 15795273.
Switzer WM, Salemi M, Shanmugam V, Gao F, Cong ME, Kuiken C, Bhullar V, Beer BE, Vallet D, Gautier-Hion A, Tooze Z, Villinger F, Holmes EC, Heneine W. Ancient co-speciation of simian foamy viruses and primates. Nature 434(7031):376-80, 2005. e-Pub 2005. PMID: 15772660.
Sui Y, Li S, Pinson D, Adany I, Li Z, Villinger F, Narayan O, Buch S. Simian human immunodeficiency virus-associated pneumonia correlates with increased expression of MCP-1, CXCL10, and viral RNA in the lungs of rhesus macaques. Am J Pathol 166(2):355-65, 2005. e-Pub 2005. PMID: 15681820.
Villinger F, Miller R, Mori K, Mayne AE, Bostik P, Sundstrom JB, Sugimoto C, Ansari AA. IL-15 is superior to IL-2 in the generation of long-lived antigen specific memory CD4 and CD8 T cells in rhesus macaques. Vaccine 22(25-26):3510-21, 2004. e-Pub 2004. PMID: 15308379.
Sundstrom JB, Little DM, Villinger F, Ellis JE, Ansari AA. Signaling through Toll-like receptors triggers HIV-1 replication in latently infected mast cells. J Immunol 172(7):4391-401, 2004. e-Pub 2004. PMID: 15034054.
Safley SA, Villinger F, Jackson EH, Tucker-Burden C, Cohen C, Weber CJ. Interleukin-6 production and secretion by human parathyroids. Clin Exp Immunol 136(1):145-56, 2004. e-Pub 2004. PMID: 15030526.
Bostik P, Watkins M, Villinger F, Ansari AA. Genetic analysis of cytokine promoters in nonhuman primates: implications for Th1/Th2 profile characteristics and SIV disease pathogenesis. Clin Dev Immunol 11(1):35-44, 2004. e-Pub 2004. PMID: 15154610.
Czub S, Czub M, Koutsilieri E, Sopper S, Villinger F, Muller JG, Stahl-Hennig C, Riederer P, Ter Meulen V, Gosztonyi G. Modulation of simian immunodeficiency virus neuropathology by dopaminergic drugs. Acta Neuropathol 107(3):216-26, 2004. e-Pub 2004. PMID: 14712399.
Bostik P, Dodd GL, Villinger F, Mayne AE, Ansari AA. Dysregulation of the polo-like kinase pathway in CD4+ T cells is characteristic of pathogenic simian immunodeficiency virus infection. J Virol 78(3):1464-72, 2004. e-Pub 2004. PMID: 14722302.
Sundstrom JB, Mao H, Santoianni R, Villinger F, Little DM, Huynh TT, Mayne AE, Hao E, Ansari AA. Magnetic resonance imaging of activated proliferating rhesus macaque T cells labeled with superparamagnetic monocrystalline iron oxide nanoparticles. J Acquir Immune Defic Syndr 35(1):9-21, 2004. e-Pub 2004. PMID: 14707787.
Vagts DA, Iber T, Puccini M, Szabo B, Haberstroh J, Villinger F, Geiger K, Noldge-Schomburg GFE. The effects of thoracic epidural anesthesia on hepatic perfusion and oxygenation in healthy pigs during general anesthesia and surgical stress. Anesth Analg 97(6):1824-1832, 2003. e-Pub 2003. PMID: 14633568.
O'Neill E, Bostik V, Montefiori DC, Kraiselburd E, Villinger F. IL-12/GM-CSF coadministration in an SIV DNA prime/protein boost protocol enhances Gag-specific T cells but not virus-specific neutralizing antibodies in rhesus macaques. AIDS Res Hum Retroviruses 19(10):883-90, 2003. e-Pub 2003. PMID: 14585220.
Buge SL, Ma HL, Amara RR, Wyatt LS, Earl PL, Villinger F, Montefiori DC, Staprans SI, Xu Y, Carter E, O'Neil SP, Herndon JG, Hill E, Moss B, Robinson HL, McNicholl JM. Gp120-alum boosting of a Gag-Pol-Env DNA/MVA AIDS vaccine: poorer control of a pathogenic viral challenge. AIDS Res Hum Retroviruses 19(10):891-900, 2003. e-Pub 2003. PMID: 14585221.
Sui Y, Potula R, Pinson D, Adany I, Li Z, Day J, Buch E, Segebrecht J, Villinger F, Liu Z, Huang M, Narayan O, Buch S. Microarray analysis of cytokine and chemokine genes in the brains of macaques with SHIV-encephalitis. J Med Primatol 32(4-5):229-39, 2003. e-Pub 2003. PMID: 14498983.
Sundstrom JB, Jollow KC, Braud V, Villinger F, McMichael AJ, Lawrencec EC, Ades EW, Ansari AA. Magnitude of alloresponses to MHC class I/II expressing human cardiac myocytes is limited by their intrinsic ability to process and present antigenic peptides. Clin Dev Immunol 10(2-4):213-26, 2003. e-Pub 2003. PMID: 14768954.
Villinger F, Mayne AE, Bostik P, Mori K, Jensen PE, Ahmed R, Ansari AA. Evidence for antibody-mediated enhancement of simian immunodeficiency virus (SIV) Gag antigen processing and cross presentation in SIV-infected rhesus macaques. J Virol 77(1):10-24, 2003. e-Pub 2003. PMID: 12477806.
Lena P, Villinger F, Giavedoni L, Miller CJ, Rhodes G, Luciw P. Co-immunization of rhesus macaques with plasmid vectors expressing IFN-gamma, GM-CSF, and SIV antigens enhances anti-viral humoral immunity but does not affect viremia after challenge with highly pathogenic virus. Vaccine 20 Suppl 4:A69-79, 2002. e-Pub 2002. PMID: 12477432.
Makitalo B, Andersson M, Arestrom I, Karlen K, Villinger F, Ansari A, Paulie S, Thorstensson R, Ahlborg N. ELISpot and ELISA analysis of spontaneous, mitogen-induced and antigen-specific cytokine production in cynomolgus and rhesus macaques. J Immunol Methods 270(1):85-97, 2002. e-Pub 2002. PMID: 12379341.
Tang Y, Villinger F, Staprans SI, Amara RR, Smith JM, Herndon JG, Robinson HL. Slowly declining levels of viral RNA and DNA in DNA/recombinant modified vaccinia virus Ankara-vaccinated macaques with controlled simian-human immunodeficiency virus SHIV-89.6P challenges. J Virol 76(20):10147-54, 2002. e-Pub 2002. PMID: 12239289.
Hicks A, Potula R, Sui YJ, Villinger F, Pinson D, Adany I, Li Z, Long C, Cheney P, Marcario J, Novembre F, Mueller N, Kumar A, Major E, Narayan O, Buch S. Neuropathogenesis of lentiviral infection in macaques: roles of CXCR4 and CCR5 viruses and interleukin-4 in enhancing monocyte chemoattractant protein-1 production in macrophages. Am J Pathol 161(3):813-22, 2002. e-Pub 2002. PMID: 12213709.
O'Neill E, Martinez I, Villinger F, Rivera M, Gascot S, Colon C, Arana T, Sidhu M, Stout R, Montefiori DC, Martinez M, Ansari AA, Israel ZR, Kraiselburd E. Protection by SIV VLP DNA prime/protein boost following mucosal SIV challenge is markedly enhanced by IL-12/GM-CSF co-administration. J Med Primatol 31(4-5):217-27, 2002. e-Pub 2002. PMID: 12390544.
Amara RR, Villinger F, Staprans SI, Altman JD, Montefiori DC, Kozyr NL, Xu Y, Wyatt LS, Earl PL, Herndon JG, McClure HM, Moss B, Robinson HL. Different patterns of immune responses but similar control of a simian-human immunodeficiency virus 89.6P mucosal challenge by modified vaccinia virus Ankara (MVA) and DNA/MVA vaccines. J Virol 76(15):7625-31, 2002. e-Pub 2002. PMID: 12097576.
Amara RR, Smith JM, Staprans SI, Montefiori DC, Villinger F, Altman JD, O'Neil SP, Kozyr NL, Xu Y, Wyatt LS, Earl PL, Herndon JG, McNicholl JM, McClure HM, Moss B, Robinson HL. Critical role for Env as well as Gag-Pol in control of a simian-human immunodeficiency virus 89.6P challenge by a DNA prime/recombinant modified vaccinia virus Ankara vaccine. J Virol 76(12):6138-46, 2002. e-Pub 2002. PMID: 12021347.
van der Meide PH, Villinger F, Ansari AA, Groenestein RJ, de Labie MC, van den Hout YJ, Koornstra WH, Bogers WM, Heeney JL. Stimulation of both humoral and cellular immune responses to HIV-1 gp120 by interleukin-12 in Rhesus macaques. Vaccine 20(17-18):2296-302, 2002. e-Pub 2002. PMID: 12009285.
Kumar S, Villinger F, Oakley M, Aguiar JC, Jones TR, Hedstrom RC, Gowda K, Chute J, Stowers A, Kaslow DC, Thomas EK, Tine J, Klinman D, Hoffman SL, Weiss WW. A DNA vaccine encoding the 42 kDa C-terminus of merozoite surface protein 1 of Plasmodium falciparum induces antibody, interferon-gamma and cytotoxic T cell responses in rhesus monkeys: immuno-stimulatory effects of granulocyte macrophage-colony stimulating factor. Immunol Lett 81(1):13-24, 2002. e-Pub 2002. PMID: 11841841.
Buch SJ, Villinger F, Pinson D, Hou Y, Adany I, Li Z, Dalal R, Raghavan R, Kumar A, Narayan O. Innate differences between simian-human immunodeficiency virus (SHIV)(KU-2)-infected rhesus and pig-tailed macaques in development of neurological disease. Virology 295(1):54-62, 2002. e-Pub 2002. PMID: 12033765.
Ansari AA, Mayne AE, Sundstrom JB, Bostik P, Grimm B, Altman JD, Villinger F. Administration of recombinant rhesus interleukin-12 during acute simian immunodeficiency virus (SIV) infection leads to decreased viral loads associated with prolonged survival in SIVmac251-infected rhesus macaques. J Virol 76(4):1731-43, 2002. e-Pub 2002. PMID: 11799168.
Villinger F, Brice GT, Mayne AE, Bostik P, Mori K, June CH, Ansari AA. Adoptive transfer of simian immunodeficiency virus (SIV) naive autologous CD4(+) cells to macaques chronically infected with SIV is sufficient to induce long-term nonprogressor status. Blood 99(2):590-9, 2002. e-Pub 2002. PMID: 11781243.
Bostik P, Wu P, Dodd GL, Villinger F, Mayne AE, Bostik V, Grimm BD, Robinson D, Kung HJ, Ansari AA. Identification of protein kinases dysregulated in CD4(+) T cells in pathogenic versus apathogenic simian immunodeficiency virus infection. J Virol 75(23):11298-306, 2001. e-Pub 2001. PMID: 11689610.
Hutchinson KL, Villinger F, Miranda ME, Ksiazek TG, Peters CJ, Rollin PE. Multiplex analysis of cytokines in the blood of cynomolgus macaques naturally infected with Ebola virus (Reston serotype). J Med Virol 65(3):561-6, 2001. e-Pub 2001. PMID: 11596094.
Villinger F, Rowe T, Parekh BS, Green TA, Mayne AE, Grimm B, McClure HM, Lackner AA, Dailey PJ, Ansari AA, Folks TM. Chronic immune stimulation accelerates SIV-induced disease progression. J Med Primatol 30(5):254-9, 2001. e-Pub 2001. PMID: 11990240.
Ansari AA, Bostik P, Mayne AE, Villinger F. Failure to expand influenza and tetanus toxoid memory T cells in vitro correlates with disease course in SIV infected rhesus macaques. Cell Immunol 210(2):125-42, 2001. e-Pub 2001. PMID: 11520079.
Villinger F, Bostik P, Mayne A, King CL, Genain CP, Weiss WR, Ansari AA. Cloning, sequencing, and homology analysis of nonhuman primate Fas/Fas-ligand and co-stimulatory molecules. Immunogenetics 53(4):315-28, 2001. e-Pub 2001. PMID: 11491535.
Amara RR, Villinger F, Altman JD, Lydy SL, O'Neil SP, Staprans SI, Montefiori DC, Xu Y, Herndon JG, Wyatt LS, Candido MA, Kozyr NL, Earl PL, Smith JM, Ma HL, Grimm BD, Hulsey ML, Miller J, McClure HM, McNicholl JM, Moss B, Robinson HL. Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Science 292(5514):69-74, 2001. e-Pub 2001. PMID: 11393868.
Buch S, Pinson D, King CL, Raghavan R, Hou Y, Li Z, Adany I, Hicks A, Villinger F, Kumar A, Narayan O. Inhibitory and enhancing effects of IFN-gamma and IL-4 on SHIV(KU) replication in rhesus macaque macrophages: correlation between Th2 cytokines and productive infection in tissue macrophages during late-stage infection. Cytokine 13(5):295-304, 2001. e-Pub 2001. PMID: 11243708.
Giambartolomei GH, Lasater BL, Villinger F, Dennis VA. Diminished expression of the costimulatory ligand CD80 (B7.1) gene correlates with antigen-specific cellular unresponsiveness in rhesus monkeys with lymphatic filariasis. Acta Trop 78(1):67-71, 2001. e-Pub 2001. PMID: 11164754.
Bostik P, Mayne AE, Villinger F, Greenberg KP, Powell JD, Ansari AA. Relative resistance in the development of T cell anergy in CD4+ T cells from simian immunodeficiency virus disease-resistant sooty mangabeys. J Immunol 166(1):506-16, 2001. e-Pub 2001. PMID: 11123330.
Villinger F, Switzer WM, Parekh BS, Otten RA, Adams D, Shanmugam V, Bostik P, Mayne AE, Chikkala NF, McClure HM, Novembre F, Yao Q, Heneine W, Folks TM, Ansari AA. Induction of long-term protective effects against heterologous challenge in SIVhu-infected macaques. Virology 278(1):194-206, 2000. e-Pub 2000. PMID: 11112494.
Lehner T, Mitchell E, Bergmeier L, Singh M, Spallek R, Cranage M, Hall G, Dennis M, Villinger F, Wang Y. The role of gammadelta T cells in generating antiviral factors and beta-chemokines in protection against mucosal simian immunodeficiency virus infection. Eur J Immunol 30(8):2245-56, 2000. e-Pub 2000. PMID: 10940916.
Zhu Y, Koo K, Bradshaw JD, Sutton WF, Kuller LR, Bucala R, Anderson D, Mossman SP, Villinger F, Haigwood NL. Macaque blood-derived antigen-presenting cells elicit SIV-specific immune responses. J Med Primatol 29(3-4):182-92, 2000. e-Pub 2000. PMID: 11085581.
Mori K, Yasutomi Y, Sawada S, Villinger F, Sugama K, Rosenwith B, Heeney JL, Uberla K, Yamazaki S, Ansari AA, Rubsamen-Waigmann H. Suppression of acute viremia by short-term postexposure prophylaxis of simian/human immunodeficiency virus SHIV-RT-infected monkeys with a novel reverse transcriptase inhibitor (GW420867) allows for development of potent antiviral immune responses resulting in efficient containment of infection. J Virol 74(13):5747-53, 2000. e-Pub 2000. PMID: 10846052.
Bostik P, Brice GT, Greenberg KP, Mayne AE, Villinger F, Lewis MG, Ansari AA. Inverse correlation of telomerase activity/proliferation of CD4+ T lymphocytes and disease progression in simian immunodeficiency virus-infected nonhuman primates. J Acquir Immune Defic Syndr 24(2):89-99, 2000. e-Pub 2000. PMID: 10935683.
Villinger F, Bucur S, Chikkala NF, Brar SS, Bostik P, Mayne AE, Adams J, Lee ME, Novembre FJ, Gately MK, Ansari AA, Hillyer CD. In vitro and in vivo responses to interleukin 12 are maintained until the late SIV infection stage but lost during AIDS. AIDS Res Hum Retroviruses 16(8):751-63, 2000. e-Pub 2000. PMID: 10826482.
Brice GT, Mayne AE, Villinger F, Ansari AA. A novel role for tumor necrosis factor-alpha in regulating susceptibility of activated CD4+ T cells from human and nonhuman primates for distinct coreceptor using lentiviruses. J Acquir Immune Defic Syndr 24(1):10-22, 2000. e-Pub 2000. PMID: 10877490.
Arredondo J, Xusheng Lu F, Villinger F, McChesney MB, McGhee JR, Miller CJ. Antigen-dependent cytokine mRNA expression by individual rhesus macaque T helper cells by flow cytometry. Cell Immunol 201(2):94-108, 2000. e-Pub 2000. PMID: 10831319.
Bucur SZ, Gillespie TW, Lee ME, Adams JW, Bray RA, Villinger F, Ansari AA, Hillyer CD. Hematopoietic response to lineage-non-specific (rrIL-3) and lineage-specific (rhG-CSF, rhEpo, rhTpo) cytokine administration in SIV-infected rhesus macaques is related to stage of infection. J Med Primatol 29(2):47-56, 2000. e-Pub 2000. PMID: 10950451.
Bostik P, Winter J, Ksiazek TG, Rollin PE, Villinger F, Zaki SR, Peters CJ, Ansari AA. Sin nombre virus (SNV) Ig isotype antibody response during acute and convalescent phases of hantavirus pulmonary syndrome. Emerg Infect Dis 6(2):184-7, 2000. e-Pub 2000. PMID: 10756154.
Brice GT, Mayne AE, Leighton K, Villinger F, Allan JS, Ansari AA. Studies of CD40L expression by lymphoid cells from experimentally and naturally SIV-infected nonhuman primate species. J Med Primatol 28(2):49-56, 1999. e-Pub 1999. PMID: 10431693.
Villinger F, Brice GT, Mayne A, Bostik P, Ansari AA. Control mechanisms of virus replication in naturally SIVsmm infected mangabeys and experimentally infected macaques. Immunol Lett 66(1-3):37-46, 1999. e-Pub 1999. PMID: 10203032.
Villinger F, Rollin PE, Brar SS, Chikkala NF, Winter J, Sundstrom JB, Zaki SR, Swanepoel R, Ansari AA, Peters CJ. Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection. J Infect Dis 179 Suppl 1:S188-91, 1999. e-Pub 1999. PMID: 9988183.
Brice GT, Riley JL, Villinger F, Mayne A, Hillyer CD, June CH, Ansari AA. Development of an animal model for autotransfusion therapy: in vitro characterization and analysis of anti-CD3/CD28 expanded cells. J Acquir Immune Defic Syndr Hum Retrovirol 19(3):210-20, 1998. e-Pub 1998. PMID: 9803962.
Lee ME, Adams JW, Villinger F, Brar SS, Meadows M, Bucur SZ, Lackey DA 3rd, Brice GT, Cruikshank WW, Ansari AA, Hillyer CD. Molecular cloning and expression of rhesus macaque and sooty mangabey interleukin 16: biologic activity and effect on simian immunodeficiency virus infection and/or replication. AIDS Res Hum Retroviruses 14(15):1323-8, 1998. e-Pub 1998. PMID: 9788673.
Giambartolomei GH, Lasater BL, Villinger F, Dennis VA. Diminished production of T helper 1 cytokines and lack of induction of IL-2R+ T cells correlate with T-cell unresponsiveness in rhesus monkeys chronically infected with Brugia malayi. Exp Parasitol 90(1):77-85, 1998. e-Pub 1998. PMID: 9709033.
Courgnaud V, Saurin W, Villinger F, Sonigo P. Different evolution of simian immunodeficiency virus in a natural host and a new host. Virology 247(1):41-50, 1998. e-Pub 1998. PMID: 9683570.
Duque S, Montenegro-James S, Arevalo-Herrera M, Praba AD, Villinger F, Herrera S, James MA. Expression of cytokine genes in Aotus monkeys immunized with synthetic and recombinant Plasmodium vivax and P. falciparum antigens. Ann Trop Med Parasitol 92(5):553-9, 1998. e-Pub 1998. PMID: 9797828.
Bucur SZ, Lackey DA 3rd, Adams JW, Lee ME, Villinger F, Mayne A, Bray RA, Winton EF, Novembre F, Strobert EA, De Rosayro J, Dailey PJ, Ansari AA, Hillyer CD. Hematologic and virologic effects of lineage-specific and non-lineage-specific recombinant human and rhesus cytokines in a cohort of SIVmac239-infected macaques. AIDS Res Hum Retroviruses 14(8):651-60, 1998. e-Pub 1998. PMID: 9618076.
Bostik P, Villinger F, Brice GT, Chikkala NF, Brar SS, Cruikshank WW, Adams JW, Hillyer CD, Ansari AA. Expression and in vitro evaluation of rhesus macaque wild type (wt) and modified CC chemokines. J Med Primatol 27(2-3):113-20, 1998. e-Pub 1998. PMID: 9747952.
Smit-McBride Z, Mattapallil JJ, Villinger F, Ansari AA, Dandekar S. Intracellular cytokine expression in the CD4+ and CD8+ T cells from intestinal mucosa of simian immunodeficiency virus infected macaques. J Med Primatol 27(2-3):129-40, 1998. e-Pub 1998. PMID: 9747954.
Folks T, Rowe T, Villinger F, Parekh B, Mayne A, Anderson D, McClure H, Ansari AA. Immune stimulation may contribute to enhanced progression of SIV induced disease in rhesus macaques. J Med Primatol 26(4):181-9, 1997. e-Pub 1997. PMID: 9416568.
Rosenberg YJ, Cafaro A, Brennan T, Greenhouse JG, Villinger F, Ansari AA, Brown C, McKinnon K, Bellah S, Yalley-Ogunro J, Elkins WR, Gartner S, Lewis MG. Virus-induced cytokines regulate circulating lymphocyte levels during primary SIV infections. Int Immunol 9(5):703-12, 1997. e-Pub 1997. PMID: 9184915.
Villinger F, Brar SS, Brice GT, Chikkala NF, Novembre FJ, Mayne AE, Bucur S, Hillyer CD, Ansari AA. Immune and hematopoietic parameters in HIV-1-infected chimpanzees during clinical progression toward AIDS. J Med Primatol 26(1-2):11-8, 1997. e-Pub 1997. PMID: 9271184.
Hoffman SL, Crutcher JM, Puri SK, Ansari AA, Villinger F, Franke ED, Singh PP, Finkelman F, Gately MK, Dutta GP, Sedegah M. Sterile protection of monkeys against malaria after administration of interleukin-12. Nat Med 3(1):80-3, 1997. e-Pub 1997. PMID: 8986746.
Genain CP, Abel K, Belmar N, Villinger F, Rosenberg DP, Linington C, Raine CS, Hauser SL. Late complications of immune deviation therapy in a nonhuman primate. Science 274(5295):2054-7, 1996. e-Pub 1996. PMID: 8953031.
Villinger F, Folks TM, Lauro S, Powell JD, Sundstrom JB, Mayne A, Ansari AA. Immunological and virological studies of natural SIV infection of disease-resistant nonhuman primates. Immunol Lett 51(1-2):59-68, 1996. e-Pub 1996. PMID: 8811346.
Brice GT, Villinger F, Mayne A, Sundstrom JB, Ansari AA. Detection of intracellular signal transduction molecules in PBMC from rhesus macaques and sooty mangabeys. J Med Primatol 25(3):210-7, 1996. e-Pub 1996. PMID: 8892042.
Benveniste O, Vaslin B, Villinger F, Le Grand R, Ansari AA, Dormont D. Cytokine mRNA levels in unmanipulated (ex vivo) and in vitro stimulated monkey PBMCs using a semi-quantitative RT-PCR and high sensitivity fluorescence-based detection strategy. Cytokine 8(1):32-41, 1996. e-Pub 1996. PMID: 8742064.
Villinger F, Brar SS, Mayne A, Chikkala N, Ansari AA. Comparative sequence analysis of cytokine genes from human and nonhuman primates. J Immunol 155(8):3946-54, 1995. e-Pub 1995. PMID: 7561102.
Neal TF, Holland HK, Baum CM, Villinger F, Ansari AA, Saral R, Wingard JR, Fleming WH. CD34+ progenitor cells from asymptomatic patients are not a major reservoir for human immunodeficiency virus-1. Blood 86(5):1749-56, 1995. e-Pub 1995. PMID: 7544640.
Ansari AA, Mayne A, Sundstrom JB, Gravanis MB, Kanter K, Sell KW, Villinger F, Siu CO, Herskowitz A. Frequency of hypoxanthine guanine phosphoribosyltransferase (HPRT-) T cells in the peripheral blood of cardiac transplant recipients. A noninvasive technique for the diagnosis of allograft rejection. Circulation 92(4):862-74, 1995. e-Pub 1995. PMID: 7641367.
Ansari AA, Sundstrom JB, Kanter K, Mayne A, Villinger F, Gravanis MB, Herskowitz A. Cellular and molecular mechanisms of human cardiac myocyte injury after transplantation. J Heart Lung Transplant 14(1 Pt 1):102-12, 1995. e-Pub 1995. PMID: 7727458.
Ansari AA, Neckelmann N, Villinger F, Leung P, Danner DJ, Brar SS, Zhao S, Gravanis MB, Mayne A, Gershwin ME, et al.. Epitope mapping of the branched chain alpha-ketoacid dehydrogenase dihydrolipoyl transacylase (BCKD-E2) protein that reacts with sera from patients with idiopathic dilated cardiomyopathy. J Immunol 153(10):4754-65, 1994. e-Pub 1994. PMID: 7963542.
Rosenberg YJ, Lewis MG, Villinger F, Ansari AA. Cytokines and simian immunodeficiency virus infections. Res Immunol 145(8-9):706-12; discussion 712-3, 1994. e-Pub 1994. PMID: 7754224.
Knuchel M, Bednarik DP, Chikkala N, Villinger F, Folks TM, Ansari AA. Development of a novel quantitative assay for the measurement of chloramphenicol acetyl transferase (CAT) mRNA. J Virol Methods 48(2-3):325-38, 1994. e-Pub 1994. PMID: 7989447.
Jehuda-Cohen T, Powell JD, Villinger F, Mayne AE, Sell KW, Ansari AA. Evidence for simian immunodeficiency virus-specific IgM and IgG response in peripheral blood mononuclear cells of serum enzyme-linked immunosorbent assay-negative nonhuman primates. J Acquir Immune Defic Syndr (1988) 7(6):539-50, 1994. e-Pub 1994. PMID: 8176639.
Ansari AA, Mayne A, Hunt D, Sundstrom JB, Villinger F. TH1/TH2 subset analysis. I. Establishment of criteria for subset identification in PBMC samples from nonhuman primates. J Med Primatol 23(2-3):102-7, 1994. e-Pub 1994. PMID: 7966223.
Rice WG, Schaeffer CA, Graham L, Bu M, McDougal JS, Orloff SL, Villinger F, Young M, Oroszlan S, Fesen MR, et al.. The site of antiviral action of 3-nitrosobenzamide on the infectivity process of human immunodeficiency virus in human lymphocytes. Proc Natl Acad Sci U S A 90(20):9721-4, 1993. e-Pub 1993. PMID: 7692451.
Villinger F, Hunt D, Mayne A, Vuchetich M, Findley H, Ansari AA. Qualitative and quantitative studies of cytokines synthesized and secreted by non-human primate peripheral blood mononuclear cells. Cytokine 5(5):469-79, 1993. e-Pub 1993. PMID: 8142603.
Hillyer CD, Lackey DA 3rd, Villinger F, Winton EF, McClure HM, Ansari AA. CD34+ and CFU-GM progenitors are significantly decreased in SIVsmm9 infected rhesus macaques with minimal evidence of direct viral infection by polymerase chain reaction. Am J Hematol 43(4):274-8, 1993. e-Pub 1993. PMID: 7690518.
Ansari AA, Wang YC, Kanter K, Villinger F, Mayne A, Sell KW, Herskowitz A. Host T-cell primary allosensitization to MHC class-I- and class-II-expressing human cardiac myocytes requires the presence of a second signal. Hum Immunol 37(2):108-18, 1993. e-Pub 1993. PMID: 8226137.
Powell JD, Bednarik DP, Folks TM, Jehuda-Cohen T, Villinger F, Sell KW, Ansari AA. Inhibition of cellular activation of retroviral replication by CD8+ T cells derived from non-human primates. Clin Exp Immunol 91(3):473-81, 1993. e-Pub 1993. PMID: 8383022.
Rice WG, Schaeffer CA, Harten B, Villinger F, South TL, Summers MF, Henderson LE, Bess JW Jr, Arthur LO, McDougal JS, et al.. Inhibition of HIV-1 infectivity by zinc-ejecting aromatic C-nitroso compounds. Nature 361(6411):473-5, 1993. e-Pub 1993. PMID: 8429889.
Rudolph DL, Yee J, Mone J, Foung SK, Lipka JJ, Reyes GR, Hadlock K, Chan L, Villinger F, Lairmore MD, et al.. Serologic confirmation of simian T-lymphotropic virus type I infection by using immunoassays developed for human T-lymphotropic virus antibody detection. J Clin Microbiol 30(4):858-61, 1992. e-Pub 1992. PMID: 1349306.
Powell JD, Bednarik DP, Jehuda-Cohen T, Villinger F, Folks TM, Ansari AA. Regulation of immune activation/retroviral replication by CD8+ T cells. Ann N Y Acad Sci 636:360-2, 1991. e-Pub 1991. PMID: 1665323.
McClure HM, Anderson DC, Fultz PN, Ansari AA, Jehuda-Cohen T, Villinger F, Klumpp SA, Switzer W, Lockwood E, Brodie A, et al.. Maternal transmission of SIVsmm in rhesus macaques. J Med Primatol 20(4):182-7, 1991. e-Pub 1991. PMID: 1942008.
Jehuda-Cohen T, Powell JD, Sell KW, Villinger F, Lockwood E, McClure HM, Ahmed-Ansari A. Transmission of retroviral infection by transfusion of seronegative blood in nonhuman primates. J Infect Dis 163(6):1223-8, 1991. e-Pub 1991. PMID: 2037788.
De BK, Lairmore MD, Griffis K, Williams LJ, Villinger F, Quinn TC, Brown C, Nzilambi, Sugimoto M, Araki S, et al.. Comparative analysis of nucleotide sequences of the partial envelope gene (5' domain) among human T lymphotropic virus type I (HTLV-I) isolates. Virology 182(1):413-9, 1991. e-Pub 1991. PMID: 2024477.
Villinger F, Powell JD, Jehuda-Cohen T, Neckelmann N, Vuchetich M, De B, Folks TM, McClure HM, Ansari AA. Detection of occult simian immunodeficiency virus SIVsmm infection in asymptomatic seronegative nonhuman primates and evidence for variation in SIV gag sequence between in vivo- and in vitro-propagated virus. J Virol 65(4):1855-62, 1991. e-Pub 1991. PMID: 2002546.
Genovesi EV, Villinger F, Gerstner DJ, Whyard TC, Knudsen RC. Effect of macrophage-specific colony-stimulating factor (CSF-1) on swine monocyte/macrophage susceptibility to in vitro infection by African swine fever virus. Vet Microbiol 25(2-3):153-76, 1990. e-Pub 1990. PMID: 2281603.
Jehuda-Cohen T, Slade BA, Powell JD, Villinger F, De B, Folks TM, McClure HM, Sell KW, Ahmed-Ansari A. Polyclonal B-cell activation reveals antibodies against human immunodeficiency virus type 1 (HIV-1) in HIV-1-seronegative individuals. Proc Natl Acad Sci U S A 87(10):3972-6, 1990. e-Pub 1990. PMID: 2111024.
Powell JD, Yehuda-Cohen T, Villinger F, McClure HM, Sell KW, Ahmed-Ansari A. Inhibition of SIV/SMM replication in vitro by CD8+ cells from SIV/SMM infected seropositive clinically asymptomatic sooty mangabeys. J Med Primatol 19(3-4):239-49, 1990. e-Pub 1990. PMID: 1700128.
Villinger F, Genovesi EV, Gerstner DJ, Whyard TC, Knudsen RC. Inhibition of African swine fever virus in cultured swine monocytes by phosphonoacetic acid (PAA) and by phosphonoformic acid (PFA). Arch Virol 115(3-4):163-84, 1990. e-Pub 1990. PMID: 2148081.
Yehuda-Cohen T, Powell JD, Villinger F, McClure HM, Sell KW, Ahmed-Ansari A. Comparison of SIV/SMM replication in CD4+ T cell and monocyte/macrophage cultures from rhesus macaques and sooty mangabeys. J Med Primatol 19(3-4):251-67, 1990. e-Pub 1990. PMID: 1700129.
Powell JD, Villinger F, Yehuda-Cohen T, Vuchetich M, McClure HM, Sell KW, Ahmed-Ansari A. Identification of SIV/SMM viral proteins that induce T cell response in experimentally infected rhesus macaques and naturally infected sooty mangabeys by the cellular western blot assay. J Med Primatol 19(3-4):227-38, 1990. e-Pub 1990. PMID: 2231683.
Villinger F, Mueller HK, Bruckner L, Ackermann M, Kihm U. Antibodies to foot-and-mouth disease virus infection associated (VIA) antigen: use of a bioengineered VIA protein as antigen in an ELISA. Vet Microbiol 20(3):235-46, 1989. e-Pub 1989. PMID: 2549685.

Review Articles

Arthos J, Cicala C, Nawaz F, Byrareddy SN, Villinger F, Santangelo PJ, Ansari AA, Fauci AS. The Role of Integrin alpha(4)beta(7) in HIV Pathogenesis and Treatment. Curr HIV/AIDS Rep 15(2):127-135, 2018. e-Pub 2018. PMID: 29478152.
Anderson DJ, Politch JA, Zeitlin L, Hiatt A, Kadasia K, Mayer KH, Ruprecht RM, Villinger F, Whaley KJ. Systemic and topical use of monoclonal antibodies to prevent the sexual transmission of HIV. AIDS 31(11):1505-1517, 2017. e-Pub 2017. PMID: 28463876.
Hong JJ, Chang KT, Villinger F. The Dynamics of T and B Cells in Lymph Node during Chronic HIV Infection: TFH and HIV, Unhappy Dance Partners?. Front Immunol 7:522, 2016. e-Pub 2016. PMID: 27920778.
Clark KB, Onlamoon N, Hsiao HM, Perng GC, Villinger F. Can non-human primates serve as models for investigating dengue disease pathogenesis?. Front Microbiol 4:305, 2013. e-Pub 2013. PMID: 24130557.
Katsikis PD, Mueller YM, Villinger F. The cytokine network of acute HIV infection: a promising target for vaccines and therapy to reduce viral set-point?. PLoS Pathog 7(8):e1002055, 2011. e-Pub 2011. PMID: 21852945.
Terry PD, Villinger F, Bubenik GA, Sitaraman SV. Melatonin and ulcerative colitis: evidence, biological mechanisms, and future research. Inflamm Bowel Dis 15(1):134-40, 2009. e-Pub 2009. PMID: 18626968.
Ansari AA, Pereira LE, Mayne AE, Onlamoon N, Pattanapanyasat K, Mori K, Villinger F. The role of disease stage, plasma viral load and regulatory T cells (Tregs) on autoantibody production in SIV-infected non-human primates. J Autoimmun 28(2-3):152-9, 2007. e-Pub 2007. PMID: 17368846.
Ansari AA, Mayne AE, Onlamoon N, Pattanapanyasat K, Mori K, Villinger F. Use of recombinant cytokines for optimized induction of antiviral immunity against SIV in the nonhuman primate model of human AIDS. Immunol Res 29(1-3):1-18, 2004. e-Pub 2004. PMID: 15181266.
Villinger F. Cytokines as clinical adjuvants: how far are we?. Expert Rev Vaccines 2(2):317-26, 2003. e-Pub 2003. PMID: 12899581.
Amara RR, Villinger F, Altman JD, Lydy SL, O'Neil SP, Staprans SI, Montefiori DC, Xu Y, Herndon JG, Wyatt LS, Candido MA, Kozyr NL, Earl PL, Smith JM, Ma HL, Grimm BD, Hulsey ML, McClure HM, McNicholl JM, Moss B, Robinson HL. Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Vaccine 20(15):1949-55, 2002. e-Pub 2002. PMID: 11983252.
Voss G, Villinger F. Adjuvanted vaccine strategies and live vector approaches for the prevention of AIDS. AIDS 14 Suppl 3:S153-65, 2000. e-Pub 2000. PMID: 11086858.
Benveniste O, Martin M, Villinger F, Dormont D. Techniques for quantification of cytokine mRNAs. Cytokines Cell Mol Ther 4(3):207-14, 1998. e-Pub 1998. PMID: 9825846.

Abstracts

Muller HK, Villinger F, Griot C, Ackermann M, Bruckner L, Kihm U. Untersuchungen zur Wirksamkeit der MKS-Impfstoffe in der Schweiz I. Schutzversuche und Herdenimmunitat. Schweiz Arch Tierheilkd 131(7):379-86, 1989. e-Pub 1989. PMID: 2552579.

Book Chapters

Villinger F. Application of the TSR-Based Method in Detecting and Quantifying Ligand- Induced Conformational Changes of 14-3-3 Proteins. In: Computational Approaches in Drug Design. Springer, 2026.
Courtney CL, Garcia A, Sharma P, Anderson DC, Cohen JK, Strobert E, Villinger F, Gumber S. Pathology of Sooty Mangabeys (Cercocebus atys). In: Natural Hosts of SIV: Implication in AIDS, 2010.
G Voss, Villinger F. Adjuvanted vaccine strategies and live vector approaches for the prevention of AIDS. In: AIDS 14: Suppl 3, 2000.
Benveniste, M Martin, Villinger F, D Dormont. Techniques for quantification of Cytokine mRNAs. In: Cytokines and Molecular Therapy. 14, 207-214, 1998.
TM Folks, Villinger F, AA Ansari. Immune activation in lentivirus infection: From Charybdis into Scylla?. In: Research in: HIV and Cytokines. M Guenounou (Ed), 7-13, 1997.
JD Powell, HM McClure, Villinger F, AA Ansari. Immunologie des primates. In: Immunologie Animale. Profs Pastoret, Govaerts et Bazin (Eds) Flammarion, 1990.

Letters to the Editor

Bostik P, Villinger F, Ansari AA, Folks TM. Pre-infection CD4+:CD8+ ratio and HIV infection. Immunol Today 18: 555-6, 1997.
Jehuda-Cohen T, Villinger F, Powell JD, McClure HM, Sell KW, Ansari AA. Presence of SIV antibodies in the sera of infants born to SIV-seronegative monkeys. J Acquir Immune Defic Syndr (1988) 4: 204-5, 1991.

Patents

Aftab A Ansari, Villinger F, Kenneth W Sell. Noninvasive Diagnosis for Allograft Rejection. Patent Number: 5,635,365.

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CV information above last modified March 06, 2026

Francois Villinger, DVM

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Francois Villinger, DVM

Present Title & Affiliation

Primary Appointment

Research Interests

Education & Training

Postgraduate Training

Licenses & Certifications

Experience & Service

Faculty Academic Appointments

Administrative Appointments/Responsibilities

Other Professional Positions

Extramural Institutional Committee Activities

Editorial Activities

Honors & Awards

Professional Memberships

Selected Presentations & Talks

National Presentations

International Presentations

Grant & Contract Support

Selected Publications

Peer-Reviewed Articles

Review Articles

Other Articles

Abstracts

Book Chapters

Letters to the Editor

Patents

Patient Reviews

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Departments and Divisions

Labs

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