Francois Villinger, DVM
Department of Comparative Medicine, Division of Discovery Science
Present Title & Affiliation
Primary Appointment
Director and Chair, Department of Michale E. Keeling Center for Comparative Medicine and Research, Division of Discover Science, The University of Texas MD Anderson Cancer Center, Bastrop, Texas
Research Interests
Characterization of the immune response against SIV in the non-human primate model of human AIDS with a special emphasis on the delineation of the mechanisms by which natural SIV infection of select African non-human primates result in disease resistance whereas Asian non-human primates following experimental infection develop disease and die from an AIDS like syndrome remarkably similar to human AIDS.
Exploration of strategies to restore immune responses and antiviral immune responses following SIV infection using combination of antiviral treatment, immunization, immunotherapies and adoptive transfer of T cell effectors.
Enhanced understanding of HIV AIDS pathogenesis and viral and immune dynamics using imaging technologies. Delineation of HIV reservoirs.
HIV vaccine research and microbicide based prevention methods.
Exploration of dengue hemorrhagic fever using a NHP model in macaques.
Restoring vaccine efficacy in elderly macaques.
EBV targeted vaccine using the macaque LCV model.
Babesiosis as a threat to the US blood bank
Schistosoma japonicum vaccine
Zika virus infection and pathogenesis
Hepatitis B in cynomolgus macaques
COVID vaccines and immunity
Evaluation of experimental HCV vaccines in NHPs.
Dengue therapeutics in NHP models.
Exploratory uses of mRNA technology to generate mucosal barriers to infection
Education & Training
Postgraduate Training
| 1989-1991 | Postgraduate Fellow, Study of Immune Mechanisms in AIDS using an Old World Primate Model for AIDS, Emory University, Atlanta, Georgia |
| 1987-1989 | Postgraduate Fellow, Immunology of African Swine Fever Virus Infection, USDA Plum Island Animal Disease Center, Greenport, NY |
Licenses & Certifications
| 1986 | Doctor of Veterinary Medicine |
| 1984 | Federal Swiss Veterinary License |
Experience & Service
Faculty Academic Appointments
Professor (Tenured), Department of Biology, University of Louisiana at Lafeyette, Lafayette, Louisiana, 2017 - 2025
Extramural Institutional Committee Activities
Member, ZRG1 IDA-R-83 panel, NIH, 2025
Chair, ZAI1-TCB-I-M2 review panel, NIH, 2021
Member, Delaney Review Panel, NIH, 2021
Standing Member, Microbiology and Infectious Diseases Research Committee (MID-B), NIH/NIAID, 2021 - 2025
Reviewer, ANRS CSS11 Panel "Maladies Infectieuses Emergentes", Agence National de Recherche sur le SIDA (ANRS), 2021 - 2025
Member, PAR Panel: ZRG1 GGG-D, NIH Genomics and Animal/Biological Resource Facilities, 2020
Chair, ZRG1 AATT-E(02) Special emphasis Panel, NIH, 2020
Chair, ZAI1 TCB-I NHP MHC and KIR Allele Discovery and Typing panel, NIH, 2020
Member, ZHL1 CSR-1 R35 Outstanding Investigator Award Panel, NIH, 2020
Member, ZRG1 GGG-A panel, NIH, 2020
Member, Scientific Review Committee, 37th Annual Nonhuman Primate Models for AIDS Symposium, 2019 - 2019
Member, ZRG1 GGG-D, NIH -Genomics and Animal/Biological Resource Facilities, 2019
Member, California HIV/AIDS Research Program (CHRP), Basic Biomedical Science Discovery Initiative, 2019
Reviewer, Research Grant Council (RGC), University of Hong Kong, 2019
Member, Executive Committee, Department of Biology, UL Lafayette, 2019 - 2022
Member, ZDE1 NB-18-1 NIDCR Special Emphasis panel, NIH, 2018
Reviewer, Applied and Biomedical Research for the Italian ministry of Health, Italian Ministry of Health, 2018
Reviewer, Research Grant Council (RGC) of the University of Hong Kong, University of Hong-Kong, 2018
N/A, ZTR1 Cl-4 (01) 1 CTSA Collaborative awards, NIH, 2018
Member, ZRG1 AARR-K (59) R panel, NIH, 2018
Member, CFAR Review Committee, NIH, 2018
Reviewer, Ministry of Health, Czech Republic, Czech Health Research Council, 2018
Member, Faculty Promotion Committee, Department of Biology, UL Lafayette, 2018 - 2025
Member, Review Committee for the Canadian Fund for Innovation, FRSQ Canada, 2017
Chair, Review Committee ZDE1 LC17, Oral HIVacc SEP, NIH, 2017
Member, Review Committee Special Emphasis ZAG1 ZIJ-5 (O2), NIH/NIA, 2017
Member, Review Committee P01 special emphasis ZAI1 PA-I(S1)1, NIH/NIAID, 2017
Member, Review Committee special emphasis CNS HIV reservoirs, NIH/NIAID, 2017
Reviewer, Research Grant Council (RGC) of Hong Kong, University of Hong Kong, 2017
Editorial Activities
Associate Editor, Frontiers in virology (Lausanne, Switzerland), 2010 - Present
Member, Experimental biology and medicine, 2009 - Present
Honors & Awards
| 2010 - Present | Woodruff Leadership Academy |
| 1991 - 1994 | Swiss National Funds for the advancement of Scientific Projects, Swiss National Funds |
Professional Memberships
Selected Presentations & Talks
National Presentations
- 2023. improving T cell responses in nonhuman primate models of AIDS. Elkin Cancer Biology Seminars at the Winship Cancer Institute. Atlanta, Georgia, US.
- 2021. Addressing HIV reservoirs under ART requires investigating many compartments beyond blood. Invited, US.
- 2021. Committee of 100 for Economic Development. Collaborations against COVID-19 across Louisiana, US.
- 2020. NIRC contribution to the fight against COVID-19. Research Town Hall, US.
- 2019. Visualizing the kinetics of nanoparticles, virus and biomarkers in real time guides treatments. Invited. NanoBio Summit 2019, US.
- 2019. Mucosal delivery of TFV via hypo‐osmolar douche as an efficacious on demand alternative to oral daily PrEP to prevent the acquisition of HIV. Invited. 2019 HIV Mucosal Systems Meeting. Chicago, Illinois, US.
- 2019. Dynamics of SIV replication under ART and post ART Interruption identifies the most likely Functional Reservoir. Invited. Miami Winter Symposium 2019. Miami, Florida, US.
- 2019. If you cannot prevent HIV infection, try to find out where it goes. Invited. Third Coast CFAR invited presentation. Chicago, Illinois, US.
- 2018. Imaging SIV rebound in real time. Invited. The Collaboration for AIDS Vaccine Discovery. Seattle, Washington, US.
- 2018. Whole Body Imaging of HIV Persistence. Novel Imaging Technologies for Detection of HIV and Associated Inflammation/Pathology in the Brain. Invited. Rockville, Maryland, US.
- 2018. Imaging from macro to microscopic level, how to focus on mechanisms of disease. Invited. . LB-AALAS Keynote. Lafayette, Louisiana, US.
- 2018. Mapping total body viral replication and immune responses, from macro to microimaging. Invited. Montgomery, Alabama, US.
- 2016. SHIV: How to prevent its transmission but if it does follow its path!. Invited. Departmental presentation. Omaha, Nebraska, US.
International Presentations
- 2025. Leveraging mRNA technologies to generate mucosal barriers to infection. Invited. KMINE 2025. Hradec Kralove, CZ.
- 2025. PET/CT guided tracking of viral reservoirs and viral rebound. Invited. EU2 Cure HIV Symposium. Ghent, BE.
- 2025. mRNA encoded antibodies to generate a protective barrier at the mucosa. Invited. Internation Conference on Emerging and Re-emerging Infectious Disease (ICER-ID 2015). Chennai, IN.
- 2025. mRNA applications in nonhuman primate models for improved preclinical evaluation. Invited. Conference of Research Workers in Animal Diseases (CRWAD). Chicago, US.
- 2024. Refining investigative approaches in NHP, leveraging imaging capabilities. Invited. Resource to Advance Pediatrics and HIV Prevention Science (RAPPS). New Orleans, US.
- 2024. PET/CT based imaging reveals immune occurrences in nonhuman primates. Invited. Invited talk. New York, US.
- 2024. Durable barrier to virus infection at the mucosa via mRNA transduction. Invited. 3rd HIV Mucosal Systems Meeting. Nashville, US.
- 2023. Chasing Viral Reservoirs and Antibody Dynamics in Nonhuman Primate Models: a key to understanding molecular processes. Invited. AVRS Conference 2023. Chennai, IN.
- 2023. Use of Nonhuman Primates as both a Preclinical and Basic Research Asset. Invited. Saveetha Medical Symposium. Chennai, IN.
- 2023. Mapping immune and viral dynamics in nonhuman primates: An exciting set of tools and glimpse into personalized medicine. Invited. One Heath Dubai. Dubai, AE.
- 2022. NIRC from a US NAVY base to the largest NHP center in the US. Invited. US-Canada Laboratory Animal Systems Forum. Buggugiate, IT.
- 2021. ImmunoPET/CT Imaging of SIV infection in real time reveals ongoing residual viral replication as one initial source of active HIV reservoirs. Invited. Total-Body PET 2021. Online, US.
- 2019. Rectal On demand PrEP as an effective and cost effective prevention of infection strategy. Invited. IDDHID. Chennai, IN.
- 2019. Identification and monitoring of HIV reservoirs under ART and post ART using whole body imaging. Invited. Chennai, IN.
- 2019. Translating Promising SIV monitoring to ATI studies in humans. 10th IAS Conference on HIV Science. Mexico City, MX.
- 2018. Mapping acute viral dynamics and rebound post ART interruption in SIV infected macaques using total body immunoPET/CT. Invited. HIVR4P. Madrid, ES.
- 2018. Tracking virus infection and immune responses in vivo: From macro to microscopic characterization. Invited. 12th Congress of the World Federation of Nuclear Medicine and Biology. Melbourne, AU.
- 2017. ImmunoPET/CT reveals the secret life of viruses and their targets in vivo. Invited. World Molecular Imaging Society Congree 2017. Philadelphia, US.
Grant & Contract Support
| Date: | 2025 - 2030 |
| Title: | Reversing effector-to-memory transition at ARTi to impact the HIV reservoirs towards ART-free control |
| Funding Source: | NIH/NIAID |
| Role: | Co-PI |
| ID: | R01AI192331 |
| Date: | 2025 - 2030 |
| Title: | Reversing effector-to-memory transition at ARTi to impact the HIV reservoir towards ART-free control |
| Funding Source: | NIH/NIAID |
| Role: | Co-PI |
| ID: | R01AI192331 |
| Date: | 2025 - 2030 |
| Title: | IL-15 Therapy combined with TGF-beta blockade for Sustained HIV |
| Funding Source: | NIH/NIAID |
| Role: | Co-I |
| ID: | 1R01AI187162 |
| Date: | 2025 - 2026 |
| Title: | Design and develop Env trimer immunogens to induce CD4bs and trimer apex |
| Funding Source: | GATES Foundation |
| Role: | Co-I |
| Date: | 2024 - 2029 |
| Title: | Intrarectal Immunization for a Barrier to Mucosal HIV Infection |
| Funding Source: | NIH/NIAID |
| Role: | Co-PI |
| ID: | R01AI179412 |
| Date: | 2024 - 2029 |
| Title: | Advancing Multi-bNAbs Microneedle Patch Technology For HIV-1 Prevention in Breastfeeding Infants (The MAMA Project) |
| Funding Source: | NIH/NIAID |
| Role: | Co-I |
| ID: | 1R01AI186784-01 |
| Date: | 2024 - 2029 |
| Title: | Assessing the Role of GI Tract Dysfunction to HIV/SIV Disease Progression |
| Funding Source: | NIH/NIDDK |
| Role: | Co-I |
| ID: | 2R01DK113919 |
| Date: | 2024 - 2028 |
| Title: | Leveraging membrane Env liposome vaccine design to elicit multi-target cross-neutralization of HIV |
| Funding Source: | NIH/NIAID |
| Role: | Co-I |
| ID: | 1R01AI183472 |
| Date: | 2024 - 2026 |
| Title: | SIV Pathogenesis in African Green Monkeys and Pigtailed Macaques |
| Funding Source: | NIH/NHLBI |
| Role: | Co-I |
| ID: | 5R01HL117715 |
| Date: | 2023 - 2027 |
| Title: | Expansion of Macaque Breeding Runs at the New Iberia Research Center |
| Funding Source: | NIH/OD/ORIP |
| Role: | PI |
| ID: | 1C06OD035570 |
| Date: | 2023 - 2027 |
| Title: | DAIDS ACC: Adjuvanting HIV vaccines supplement |
| Funding Source: | NIH/NIAID |
| Role: | Co-I |
| ID: | 75N93022C00052 |
| Date: | 2023 - 2028 |
| Title: | Probing the role of adenosine pathway in SIV pathogenesis |
| Funding Source: | NIH/NIAID |
| Role: | Co-I |
| ID: | 1R01AI179317 |
| Date: | 2023 - 2028 |
| Title: | Turning off HIV White Noise: Switching from Long-Lived to Short-Lived Reservoir |
| Funding Source: | NIH/NIAID |
| Role: | Co-I |
| ID: | 1R01AI176599 |
| Date: | 2022 - 2026 |
| Title: | Renovation of Building 29 laboratories at the New Iberia Research Center |
| Funding Source: | NIH/OD/ORIP |
| Role: | PI |
| ID: | 1C06OD034041 |
| Date: | 2022 - 2026 |
| Title: | Durable HIV Vaccine Targeting Mucosal Epithelium |
| Funding Source: | NIH/NIAID |
| Role: | Co-PI |
| ID: | 1R01AI172539 |
| Date: | 2022 - 2026 |
| Title: | Durable HIV Vaccine Targeting Mucosal Epithelium |
| Funding Source: | NIH/NIAID |
| Role: | Co-I |
| ID: | R01AI172539 |
| Date: | 2022 - 2027 |
| Title: | Unraveling the Mechanisms of HIV Persistence and Rebound |
| Funding Source: | NIH/NIAID |
| Role: | Co-I |
| ID: | 1P01AI169600 |
| Date: | 2022 - 2026 |
| Title: | Resource for Nonhuman Primate Immune Reagents |
| Funding Source: | NIH/OD/ORIP |
| Role: | PI |
| ID: | R24OD010947 |
| Date: | 2022 - 2026 |
| Title: | Role of myeloid cells in CNS and systemic reservoirs and rebound |
| Funding Source: | NIH/MH |
| Role: | Co-I |
| ID: | 1R01MH125778 |
| Date: | 2021 - 2026 |
| Title: | Sex Differences in intestinal immune dysfunction and SHIV persistence |
| Funding Source: | NIH/NIDDK |
| Role: | Co-PI |
| ID: | 1R01DK130769 |
| Date: | 2021 - 2027 |
| Title: | Identification of the Initial Targets of Transmission |
| Funding Source: | NIH/NIAID |
| Role: | Co-I |
| ID: | 5R37AI09495 |
| Date: | 2021 - 2026 |
| Title: | A vaccine design to induce protective B and T cell immunity against hepatitis C virus |
| Funding Source: | NIH/NIAID |
| Role: | Key |
| ID: | 1U19AI159840 |
| Date: | 2021 - 2026 |
| Title: | Impact of antibody effector function diversity on antiviral activity in situ |
| Funding Source: | NIH/NIAID |
| Role: | Co-I |
| ID: | 1P01AI162242 |
| Date: | 2020 - 2025 |
| Title: | Identification of SIV replication and reservoirs in the CNS |
| Funding Source: | NIH/NIMH |
| Role: | Co-PI |
| ID: | 1R01MH125395 |
| Date: | 2020 - 2026 |
| Title: | Durable vaginal protection from HIV via mRNA expression of bnAbs |
| Funding Source: | NIH/NIAID |
| Role: | Co-PI |
| ID: | 1R01AI155007 |
| Date: | 2020 - 2027 |
| Title: | SIV Vaccine Evaluation Unit (SVEU, Tasks 1,2,3 and 4) |
| Funding Source: | NIH/NIAID |
| Role: | PI |
Selected Publications
Peer-Reviewed Articles
- Manickam C, Jones R, Deb Adhikary NR, Kroll KW, Terry K, Balachandran H, Woolley G, Tomaras GD, Villinger FJ, Reeves RK. Myeloid cell recruitment and activation through systemic and mucosae-directed cytokine therapy. Immunol Cell Biol, 2025. e-Pub 2025. PMID: 41054306.
- Acharya A, Sutar D, Mohan M, Govind V, Villinger F, Pallikkuth S, Byrareddy SN. Age-Associated Expansion of HIV/SIV Reservoirs in People With HIV and SIV-Infected Macaques. Aging Cell:e70252, 2025. e-Pub 2025. PMID: 41051053.
- Spearman, P, Jin, H, Xiao, P, Knopp, K, Radziewicz, H, Tellier, M, Larsen, SE, Berube, BJ, Song, X, Kidd, J, Singh, K, Li, Z, Gingerich, MC, Wu, S, John, SP, Branche, A, Falsey, AR, Coler, R, Villinger, FJ, He, B. Safety and immunogenicity of intranasal parainfluenza virus type 5 (PIV5)–vectored COVID-19 vaccine in adults and teens in an open-label phase 1 trial. Science Advances 11(27), 2025. e-Pub 2025. PMID: 40614182.
- Whitlow, HJ, Nagy, G, Kuznetsov, A, Frost, RJ, Azarov, A, Smith, KM, Amphalop, S, Insuan, W, Wichianchot, S, Ren, MQ, Osipowicz, T, Ryan, CG, Sudprasert, W, Villinger, FJ. Major and Trace Element Composition Differences Revealed in Porcine Intestine by Dynamic Analysis and MeV Ion Microscopy. Physica Status Solidi (A) Applications and Materials Science 222(12), 2025. e-Pub 2025.
- Beavis, AC, Xiao, P, Gingerich, MC, Briggs, K, Li, G, Howerth, EW, Najera, M, An, D, Huang, J, Mousa, JJ, Tompkins, SM, Kim, G, Harvey, SB, Hogan, RJ, Lafontaine, ER, Villinger, FJ, Jin, H, He, B. A parainfluenza virus 5 (PIV5)-vectored intranasal SARS-CoV-2 vaccine (CVXGA1) elicits protective and long-lasting immunity in nonhuman primates. Journal of Virology 99(4), 2025. e-Pub 2025. PMID: 40116506.
- Johnson, SD, Pino, M, Acharya, A, Clain, JA, Bose, D, Nguyen, K, Harper, J, Villinger, FJ, Paiardini, M, Byrareddy, SN. IL-21 and anti-α4β7 dual therapy during ART promotes immunological and microbiome responses in SIV-infected macaques. JCI Insight 10(6), 2025. e-Pub 2025. PMID: 39903521.
- Peres A, Upadhyay AA, Klein VH, Saha S, Rodriguez OL, Vanwinkle ZM, Karunakaran K, Metz A, Lauer W, Lin MC, Melton T, Granholm L, Polak P, Peterson SM, Peterson EJ, Raju N, Shields K, Schultze S, Ton T, Ericsen A, Lapp SA, Villinger FJ, Ohlin M, Cottrell C, Amara RR, Derdeyn CA, Crotty S, Schief W, Karlsson Hedestam GB, Smith M, Lees W, Watson CT, Yaari G, Bosinger SE. A Broad Survey and Functional Analysis of Immunoglobulin Loci Variation in Rhesus Macaques. bioRxiv, 2025. e-Pub 2025. PMID: 39829807.
- Buckley M, Arainga M, Maiorino L, Pires IS, Kim BJ, Michaels KK, Dye J, Qureshi K, Zhang YJ, Mak H, Steichen JM, Schief WR, Villinger F, Irvine DJ. Visualizing lipid nanoparticle trafficking for mRNA vaccine delivery in non-human primates. Mol Ther 33(3):1105-1117, 2025. e-Pub 2025. PMID: 39797396.
- Govindaraj S, Ibegbu C, Ali SA, Babu H, Shanmugasundaram U, Villinger F, Amara RR, Velu V. IL-15/IL-15Ra Synergies with IL-12 to Induce Functional CD8 T Cells and NK Cells During Chronic SHIV Infection. AIDS Res Hum Retroviruses 41(3):120-123, 2025. e-Pub 2025. PMID: 39041621.
- Bose D, Rogers KA, Shirreff LM, Chebloune Y, Villinger FJ. Enhanced HIV immune responses elicited by an apoptotic single-cycle SHIV lentivector DNA vaccine. Front Cell Infect Microbiol 15:1481427, 2025. e-Pub 2025. PMID: 40292218.
- Yousefpour P, Zhang YJ, Maiorino L, Melo MB, Arainga Ramirez MA, Kumarapperuma SC, Xiao P, Silva M, Li N, Michaels KK, Georgeson E, Eskandarzadeh S, Kubitz M, Groschel B, Qureshi K, Fontenot J, Hangartner L, Nedellec R, Love JC, Burton DR, Schief WR, Villinger FJ, Irvine DJ. Modulation of antigen delivery and lymph node activation in nonhuman primates by saponin adjuvant saponin/monophosphoryl lipid A nanoparticle. PNAS Nexus 3(12):pgae529, 2024. e-Pub 2024. PMID: 39677368.
- Taylor RA, Xiao S, Carias AM, McRaven MD, Thakkar DN, Arainga M, Lorenzo-Redondo R, Allen EJ, Rogers KA, Kumarapperuma SC, Gong S, Anderson MR, Thomas Y, Madden PJ, Corti D, Cameroni E, Lanzavecchia A, Goins B, Fox P, Villinger FJ, Ruprecht RM, Hope TJ. PET/CT Targeted Tissue Sampling Reveals Intravenously Administered HGN194 IgG1 Affects HIV Distribution after Rectal Exposure. AIDS Res Hum Retroviruses 40(11):637-648, 2024. e-Pub 2024. PMID: 39104250.
- Milon TI, Wang Y, Fontenot RL, Khajouie P, Villinger F, Raghavan V, Xu W. Development of a novel representation of drug 3D structures and enhancement of the TSR-based method for probing drug and target interactions. Comput Biol Chem 112:108117, 2024. e-Pub 2024. PMID: 38852360.
- Whitlow, HJ, Kuznetsov, A, Azarov, A, Nagy, G, Frost, RJ, Henderson, N, Greco, R, Deoli, N, Smith, KM, Sudprasert, W, Amphalop, S, Insuan, W, Wichianchot, S, Ren, MQ, Osipowicz, T, Ryan, CG, Villinger, FJ. Dynamic Analysis of major elements in biological tissue validating quantification of trace life elements in MeV ion beam microscopy. Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms 554, 2024. e-Pub 2024.
- Nelson AN, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, Sewall LM, Milligan E, Davis D, Cross KA, Chen Y, van Schooten J, Eudailey J, Isaac J, Memon S, Weinbaum C, Gao H, Stanfield-Oakley S, Byrd A, Chutkan S, Berendam S, Cronin K, Yasmeen A, Alam S, LaBranche CC, Rogers K, Shirreff L, Cupo A, Derking R, Villinger F, Klasse PJ, Ferrari G, Williams WB, Hudgens MG, Ward AB, Montefiori DC, Van Rompay KKA, Wiehe K, Moore JP, Sanders RW, De Paris K, Permar SR. Immunization with germ line-targeting SOSIP trimers elicits broadly neutralizing antibody precursors in infant macaques. Sci Immunol 9(98):eadm7097, 2024. e-Pub 2024. PMID: 39213340.
- Caniels TG, Medina-Ramirez M, Zhang S, Kratochvil S, Xian Y, Koo JH, Derking R, Samsel J, van Schooten J, Pecetta S, Lamperti E, Yuan M, Carrasco MR, Del Moral Sanchez I, Allen JD, Bouhuijs JH, Yasmeen A, Ketas TJ, Snitselaar JL, Bijl TPL, Martin IC, Torres JL, Cupo A, Shirreff L, Rogers K, Mason RD, Roederer M, Greene KM, Gao H, Silva CM, Baken IJL, Tian M, Alt FW, Pulendran B, Seaman MS, Crispin M, van Gils MJ, Montefiori DC, McDermott AB, Villinger FJ, Koup RA, Moore JP, Klasse PJ, Ozorowski G, Batista FD, Wilson IA, Ward AB, Sanders RW. Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site. Sci Immunol 9(98):eadk9550, 2024. e-Pub 2024. PMID: 39213338.
- Yousefpour P, Zhang YJ, Maiorino L, Melo MB, Arainga Ramirez MA, Kumarapperuma SC, Xiao P, Silva M, Li N, Michaels KK, Georgeson E, Eskandarzadeh S, Kubitz M, Groschel B, Qureshi K, Fontenot J, Hangartner L, Nedellec R, Love JC, Burton DR, Schief WR, Villinger FJ, Irvine DJ. Modulation of antigen delivery and lymph node activation in non-human primates by saponin adjuvant SMNP. bioRxiv, 2024. e-Pub 2024. PMID: 39253464.
- Arunachalam PS, Ha N, Dennison SM, Spreng RL, Seaton KE, Xiao P, Feng Y, Zarnitsyna VI, Kazmin D, Hu M, Santagata JM, Xie X, Rogers K, Shirreff LM, Chottin C, Spencer AJ, Dutta S, Prieto K, Julien JP, Tomai M, Fox CB, Villinger F, Hill AVS, Tomaras GD, Pulendran B. A comparative immunological assessment of multiple clinical-stage adjuvants for the R21 malaria vaccine in nonhuman primates. Sci Transl Med 16(758):eadn6605, 2024. e-Pub 2024. PMID: 39083589.
- Buckley M, Arainga M, Maiorino L, Pires IS, Kim BJ, Michaels KK, Dye J, Qureshi K, Zhang Y, Mak H, Steichen JM, Schief WR, Villinger F, Irvine DJ. Visualizing lipid nanoparticle trafficking for mRNA vaccine delivery in non-human primates. bioRxiv, 2024. e-Pub 2024. PMID: 38979236.
- Deycmar S, Johnson BJ, Ray K, Schaaf GW, Ryan DP, Cullin C, Dozier BL, Ferguson B, Bimber BN, Olson JD, Caudell DL, Whitlow CT, Solingapuram Sai KK, Romero EC, Villinger FJ, Burgos AG, Ainsworth HC, Miller LD, Hawkins GA, Chou JW, Gomes B, Hettich M, Ceppi M, Charo J, Cline JM. Epigenetic MLH1 silencing concurs with mismatch repair deficiency in sporadic, naturally occurring colorectal cancer in rhesus macaques. J Transl Med 22(1):292, 2024. e-Pub 2024. PMID: 38504345.
- Bose D, Deb Adhikary N, Xiao P, Rogers KA, Ferrell DE, Cheng-Mayer C, Chang TL, Villinger F. SHIV-C109p5 NHP induces rapid disease progression in elderly macaques with extensive GI viral replication. J Virol 98(2):e0165223, 2024. e-Pub 2024. PMID: 38299866.
- Kim J, Bose D, Arainga M, Haque MR, Fennessey CM, Caddell RA, Thomas Y, Ferrell DE, Ali S, Grody E, Goyal Y, Cicala C, Arthos J, Keele BF, Vaccari M, Lorenzo-Redondo R, Hope TJ, Villinger F, Martinelli E. TGF-beta blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo. Nat Commun 15(1):1348, 2024. e-Pub 2024. PMID: 38355731.
- Winchester NE, Panigrahi S, Haria A, Chakraborty A, Su X, Chen B, Morris SR, Clagett BM, Juchnowski SM, Yadavalli R, Villinger F, Paiardini M, Harth K, Kashyap VS, Calabrese LH, Margolis L, Sieg SF, Shive CL, Gianella S, Funderburg NT, Zidar DA, Lederman MM, Freeman ML. Cytomegalovirus Infection Facilitates the Costimulation of CD57+CD28- CD8 T Cells in HIV Infection and Atherosclerosis via the CD2-LFA-3 Axis. J Immunol 212(2):245-257, 2024. e-Pub 2024. PMID: 38047900.
- Yilma AN, Sahu R, Subbarayan P, Villinger F, Coats MT, Singh SR, Dennis VA. PLGA-Chitosan Encapsulated IL-10 Nanoparticles Modulate Chlamydia Inflammation in Mice. Int J Nanomedicine 19:1287-1301, 2024. e-Pub 2024. PMID: 38348174.
- Kime J, Bose D, Arainga M, Haque MR, Fennessey CM, Caddell RA, Thomas Y, Ferrell DE, Ali S, Grody E, Goyal Y, Cicala C, Arthos J, Keele BF, Vaccari M, Lorenzo-Redondo R, Hope TJ, Villinger FJ, Marinelli E. TGF-beta blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo. bioRxiv, 2023. e-Pub 2023. PMID: 38014094.
- Nelson AN, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, Sewall LM, Milligan E, Davis D, Cross KA, Chen Y, van Schooten J, Eudailey J, Isaac J, Memon S, Weinbaum C, Stanfield-Oakley S, Byrd A, Chutkan S, Berendam S, Cronin K, Yasmeen A, Alam SM, LaBranche CC, Rogers K, Shirreff L, Cupo A, Derking R, Villinger F, Klasse PJ, Ferrari G, Williams WB, Hudgens MG, Ward AB, Montefiori DC, Van Rompay KKA, Wiehe K, Moore JP, Sanders RW, De Paris K, Permar SR. Germline-targeting SOSIP trimer immunization elicits precursor CD4 binding-site targeting broadly neutralizing antibodies in infant macaques. bioRxiv, 2023. e-Pub 2023. PMID: 37986885.
- Pallikkuth S, Kvistad D, Sirupangi T, Kizhner A, Pahwa R, Cameron MJ, Richardson B, Williams S, Ayupe A, Brooks M, Petrovas C, Villinger F, Pahwa S. IL-21-IgFc immunotherapy alters transcriptional landscape of lymph node cells leading to enhanced flu vaccine response in aging and SIV infection. Aging Cell 22(11):e13984, 2023. e-Pub 2023. PMID: 37712598.
- Spearman P, Jin H, Knopp K, Xiao P, Gingerich MC, Kidd J, Singh K, Tellier M, Radziewicz H, Wu S, McGregor M, Freda B, Wang Z, John SP, Villinger FJ, He B. Intranasal parainfluenza virus type 5 (PIV5)-vectored RSV vaccine is safe and immunogenic in healthy adults in a phase 1 clinical study. Sci Adv 9(43):eadj7611, 2023. e-Pub 2023. PMID: 37878713.
- Whitlow, HJ, Nagy, G, Henderson, N, Greco, R, Deoli, N, Smith, KM, Morgan, K, Villinger, FJ. Sequestration of Ca in simian nasal mucosa. Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms 539:152-161, 2023. e-Pub 2023.
- Feng Y, Yuan M, Powers JM, Hu M, Munt JE, Arunachalam PS, Leist SR, Bellusci L, Kim J, Sprouse KR, Adams LE, Sundaramurthy S, Zhu X, Shirreff LM, Mallory ML, Scobey TD, Moreno A, O'Hagan DT, Kleanthous H, Villinger FJ, Veesler D, King NP, Suthar MS, Khurana S, Baric RS, Wilson IA, Pulendran B. Broadly neutralizing antibodies against sarbecoviruses generated by immunization of macaques with an AS03-adjuvanted COVID-19 vaccine. Sci Transl Med 15(695):eadg7404, 2023. e-Pub 2023. PMID: 37163615.
- Drici, H, Adhikary, ND, Villinger, FJ, Hansen, EB. Dried Raw Camel Milk Spot (“DRCMS”) as a Simple and Efficient Microsampling Method from Hot and Remote Regions for Mesophilic Aerobe Count and Lactofermentation Microbiota Activity Detection. Food Analytical Methods 16(5):833-840, 2023. e-Pub 2023.
- Weidenbacher PA, Sanyal M, Friedland N, Tang S, Arunachalam PS, Hu M, Kumru OS, Morris MK, Fontenot J, Shirreff L, Do J, Cheng YC, Vasudevan G, Feinberg MB, Villinger FJ, Hanson C, Joshi SB, Volkin DB, Pulendran B, Kim PS. A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates. Nat Commun 14(1):2149, 2023. e-Pub 2023. PMID: 37069151.
- Khan M, Diop A, Gbodossou E, Xiao P, Coleman M, De Barros K, Duong H, Bond VC, Floyd V, Kondwani K, Rice VM, Harris-Hooker S, Villinger F, Powell MD. Anti-human immunodeficiency virus-1 activity of MoMo30 protein isolated from the traditional African medicinal plant Momordica balsamina. Virol J 20(1):50, 2023. e-Pub 2023. PMID: 36949470.
- Rotolo L, Vanover D, Bruno NC, Peck HE, Zurla C, Murray J, Noel RK, O'Farrell L, Arainga M, Orr-Burks N, Joo JY, Chaves LCS, Jung Y, Beyersdorf J, Gumber S, Guerrero-Ferreira R, Cornejo S, Thoresen M, Olivier AK, Kuo KM, Gumbart JC, Woolums AR, Villinger F, Lafontaine ER, Hogan RJ, Finn MG, Santangelo PJ. Species-agnostic polymeric formulations for inhalable messenger RNA delivery to the lung. Nat Mater 22(3):369-379, 2023. e-Pub 2023. PMID: 36443576.
- Feng Y, Yuan M, Powers JM, Hu M, Munt JE, Arunachalam PS, Leist SR, Bellusci L, Adams LE, Sundaramurthy S, Shirreff LM, Mallory ML, Scooby TD, Moreno A, O'Hagan DT, Kleanthous H, Villinger FJ, Veesler D, King NP, Suthar MS, Khurana S, Baric RS, Wilson IA, Pulendran B. Extremely potent pan-sarbecovirus neutralizing antibodies generated by immunization of macaques with an AS03-adjuvanted monovalent subunit vaccine against SARS-CoV-2. bioRxiv, 2023. e-Pub 2023. PMID: 36711543.
- Tuyishime M, Spreng RL, Hueber B, Nohara J, Goodman D, Chan C, Barfield R, Beck WE, Jha S, Asdell S, Wiehe K, He MM, Easterhoff D, Conley HE, Hoxie T, Gurley T, Jones C, Adhikary ND, Villinger F, Thomas R, Denny TN, Moody MA, Tomaras GD, Pollara J, Reeves RK, Ferrari G. Multivariate analysis of FcR-mediated NK cell functions identifies unique clustering among humans and rhesus macaques. Front Immunol 14:1260377, 2023. e-Pub 2023. PMID: 38124734.
- Weidenbacher PA, Sanyal M, Friedland N, Tang S, Arunachalam PS, Hu M, Kumru OS, Morris MK, Fontenot J, Shirreff L, Do J, Cheng YC, Vasudevan G, Feinberg MB, Villinger FJ, Hanson C, Joshi SB, Volkin DB, Pulendran B, Kim PS. A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates. bioRxiv, 2022. e-Pub 2022. PMID: 36597527.
- Xiao P, Gumber S, Marzinke MA, Hoang T, Myers R, Date AA, Hanes J, Ensign LM, Wang L, Rohan LC, Cone R, Fuchs EJ, Hendrix CW, Villinger F. Hypo-osmolar rectal douche tenofovir formulation prevents simian/human immunodeficiency virus acquisition in macaques. JCI Insight 7(23), 2022. e-Pub 2022. PMID: 36477356.
- Coleman MI, Khan M, Gbodossou E, Diop A, DeBarros K, Duong H, Bond VC, Floyd V, Kondwani K, Montgomery Rice V, Villinger F, Powell MD. Identification of a Novel Anti-HIV-1 Protein from Momordica balsamina Leaf Extract. Int J Environ Res Public Health 19(22), 2022. e-Pub 2022. PMID: 36429944.
- Samer S, Thomas Y, Arainga M, Carter C, Shirreff LM, Arif MS, Avita JM, Frank I, McRaven MD, Thuruthiyil CT, Heybeli VB, Anderson MR, Owen B, Gaisin A, Bose D, Simons LM, Hultquist JF, Arthos J, Cicala C, Sereti I, Santangelo PJ, Lorenzo-Redondo R, Hope TJ, Villinger FJ, Martinelli E. Blockade of TGF-beta signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo. JCI Insight 7(21), 2022. e-Pub 2022. PMID: 36125890.
- Seenappa LM, Jakubowski A, Steinbuck MP, Palmer E, Haqq CM, Carter C, Fontenot J, Villinger F, McNeil LK, DeMuth PC. Amphiphile-CpG vaccination induces potent lymph node activation and COVID-19 immunity in mice and non-human primates. NPJ Vaccines 7(1):128, 2022. e-Pub 2022. PMID: 36307453.
- Walls AC, VanBlargan LA, Wu K, Choi A, Navarro MJ, Lee D, Avena L, Berrueta DM, Pham MN, Elbashir S, Kraft JC, Miranda MC, Kepl E, Johnson M, Blackstone A, Sprouse K, Fiala B, O'Connor MA, Brunette N, Arunachalam PS, Shirreff L, Rogers K, Carter L, Fuller DH, Villinger F, Pulendran B, Diamond MS, Edwards DK, King NP, Veesler D. Distinct sensitivities to SARS-CoV-2 variants in vaccinated humans and mice. Cell Rep 40(9):111299, 2022. e-Pub 2022. PMID: 35988541.
- Arunachalam PS, Feng Y, Ashraf U, Hu M, Walls AC, Edara VV, Zarnitsyna VI, Aye PP, Golden N, Miranda MC, Green KWM, Threeton BM, Maness NJ, Beddingfield BJ, Bohm RP, Scheuermann SE, Goff K, Dufour J, Russell-Lodrigue K, Kepl E, Fiala B, Wrenn S, Ravichandran R, Ellis D, Carter L, Rogers K, Shirreff LM, Ferrell DE, Deb Adhikary NR, Fontenot J, Hammond HL, Frieman M, Grifoni A, Sette A, O'Hagan DT, Van Der Most R, Rappuoli R, Villinger F, Kleanthous H, Rappaport J, Suthar MS, Veesler D, Wang TT, King NP, Pulendran B. Durable protection against the SARS-CoV-2 Omicron variant is induced by an adjuvanted subunit vaccine. Sci Transl Med 14(658):eabq4130, 2022. e-Pub 2022. PMID: 35976993.
- Hartwell BL, Melo MB, Xiao P, Lemnios AA, Li N, Chang JYH, Yu J, Gebre MS, Chang A, Maiorino L, Carter C, Moyer TJ, Dalvie NC, Rodriguez-Aponte SA, Rodrigues KA, Silva M, Suh H, Adams J, Fontenot J, Love JC, Barouch DH, Villinger F, Ruprecht RM, Irvine DJ. Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity. Sci Transl Med 14(654):eabn1413, 2022. e-Pub 2022. PMID: 35857825.
- Rahman SA, Billingsley JM, Sharma AA, Styles TM, Govindaraj S, Shanmugasundaram U, Babu H, Riberio SP, Ali SA, Tharp GK, Ibegbu C, Waggoner SN, Johnson RP, Sekaly RP, Villinger F, Bosinger SE, Amara RR, Velu V. Lymph node CXCR5+ NK cells associate with control of chronic SHIV infection. JCI Insight 7(8), 2022. e-Pub 2022. PMID: 35271506.
- Madden PJ, Thomas Y, Blair RV, Samer S, Doyle M, Midkiff CC, Doyle-Meyers LA, Becker ME, Arif MS, McRaven MD, Simons LM, Carias AM, Martinelli E, Lorenzo-Redondo R, Hultquist JF, Villinger FJ, Veazey RS, Hope TJ. An immunoPET probe to SARS-CoV-2 reveals early infection of the male genital tract in rhesus macaques. Res Sq, 2022. e-Pub 2022. PMID: 35411346.
- Madden PJ, Thomas Y, Blair RV, Samer S, Doyle M, Midkiff CC, Doyle-Meyers LA, Becker ME, Arif MS, McRaven MD, Simons LM, Carias AM, Martinelli E, Lorenzo-Redondo R, Hultquist JF, Villinger FJ, Veazey RS, Hope TJ. An immunoPET probe to SARS-CoV-2 reveals early infection of the male genital tract in rhesus macaques. bioRxiv, 2022. e-Pub 2022. PMID: 35262081.
- Leroy LA, Mac Donald A, Kandlur A, Bose D, Xiao P, Gagnon J, Villinger F, Chebloune Y. Cytokine Adjuvants IL-7 and IL-15 Improve Humoral Responses of a SHIV LentiDNA Vaccine in Animal Models. Vaccines (Basel) 10(3), 2022. e-Pub 2022. PMID: 35335093.
- Leroy, LA, Donald, AM, Kandlur, A, Bose, D, Xiao, P, Gagnon, J, Villinger, FJ, Chebloune, Y. Cytokine Adjuvants IL-7 and IL-15 Improve Humoral Responses of a SHIV LentiDNA Vaccine in Animal Models. Vaccines 10(3), 2022. e-Pub 2022. PMID: 35335093.
- Pillet S, Arunachalam PS, Andreani G, Golden N, Fontenot J, Aye PP, Roltgen K, Lehmicke G, Gobeil P, Dube C, Trepanier S, Charland N, D'Aoust MA, Russell-Lodrigue K, Monjure C, Blair RV, Boyd SD, Bohm RP, Rappaport J, Villinger F, Landry N, Pulendran B, Ward BJ. Safety, immunogenicity, and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates. Cell Mol Immunol 19(2):222-233, 2022. e-Pub 2022. PMID: 34983950.
- Yee JL, Prongay K, Van Rompay KKA, Meesawat S, Kemthong T, Halley B, Carpenter A, Nham P, Rogers K, Hasselschwert D, Villinger F, Jay AN, Warit S, Malivijitnond S, Roberts JA. Tuberculosis detection in nonhuman primates is enhanced by use of testing algorithms that include an interferon-gamma release assay. Am J Vet Res 83(1):15-22, 2021. e-Pub 2021. PMID: 34757923.
- Silveira ELV, Hong JJ, Amancha PK, Rogers KA, Ansari AA, Byrareddy SN, Villinger F. Viremia controls Env-specific antibody-secreting cell responses in simian immunodeficiency virus infected macaques pre and post-antiretroviral therapy. AIDS 35(13):2085-2094, 2021. e-Pub 2021. PMID: 34148985.
- Taylor RA, McRaven MD, Carias AM, Anderson MR, Matias E, Arainga M, Allen EJ, Rogers KA, Gupta S, Kulkarni V, Lakhashe S, Lorenzo-Redondo R, Thomas Y, Strickland A, Villinger FJ, Ruprecht RM, Hope TJ. Localization of infection in neonatal rhesus macaques after oral viral challenge. PLoS Pathog 17(11):e1009855, 2021. e-Pub 2021. PMID: 34793582.
- Abraham M, Beavis AC, Xiao P, Villinger FJ, Li Z, Jones CA, Tompkins SM, He B. Evaluation of a New Viral Vaccine Vector in Mice and Rhesus Macaques: J Paramyxovirus Expressing Hemagglutinin of Influenza A Virus H5N1. J Virol 95(22):e0132121, 2021. e-Pub 2021. PMID: 34469242.
- Kvistad D, Pallikkuth S, Sirupangi T, Pahwa R, Kizhner A, Petrovas C, Villinger F, Pahwa S. IL-21 enhances influenza vaccine responses in aged macaques with suppressed SIV infection. JCI Insight 6(20), 2021. e-Pub 2021. PMID: 34491910.
- Walls AC, Miranda MC, Schafer A, Pham MN, Greaney A, Arunachalam PS, Navarro MJ, Tortorici MA, Rogers K, O'Connor MA, Shirreff L, Ferrell DE, Bowen J, Brunette N, Kepl E, Zepeda SK, Starr T, Hsieh CL, Fiala B, Wrenn S, Pettie D, Sydeman C, Sprouse KR, Johnson M, Blackstone A, Ravichandran R, Ogohara C, Carter L, Tilles SW, Rappuoli R, Leist SR, Martinez DR, Clark M, Tisch R, O'Hagan DT, Van Der Most R, Van Voorhis WC, Corti D, McLellan JS, Kleanthous H, Sheahan TP, Smith KD, Fuller DH, Villinger F, Bloom J, Pulendran B, Baric RS, King NP, Veesler D. Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines. Cell 184(21):5432-5447.e16, 2021. e-Pub 2021. PMID: 34619077.
- Carias AM, Schneider JR, Madden P, Lorenzo-Redondo R, Arainga M, Pegu A, Cianci GC, Maric D, Villinger F, Mascola JR, Veazey RS, Hope TJ. Anatomic Distribution of Intravenously Injected IgG Takes Approximately 1 Week to Achieve Stratum Corneum Saturation in Vaginal Tissues. J Immunol 207(2):505-511, 2021. e-Pub 2021. PMID: 34162723.
- Berard AR, Miller C, Arainga M, Broedlow CA, Noel-Romas L, Schifanella L, Hensley-McBain T, Roederer A, Driscoll CB, Coronado E, Manuzak J, McKinnon LR, Villinger F, Hope TJ, Burgener AD, Klatt NR. Simian Immunodeficiency Virus Susceptibility, Immunology, and Microbiome in the Female Genital Tract of Adolescent Versus Adult Pigtail Macaques. AIDS Res Hum Retroviruses 37(7):510-522, 2021. e-Pub 2021. PMID: 33446027.
- Taylor RA, Xiao S, Carias AM, McRaven MD, Thakkar DN, Arainga M, Allen EJ, Rogers KA, Kumarapperuma SC, Gong S, Fought AJ, Anderson MR, Thomas Y, Schneider JR, Goins B, Fox P, Villinger FJ, Ruprecht RM, Hope TJ. PET/CT targeted tissue sampling reveals virus specific dIgA can alter the distribution and localization of HIV after rectal exposure. PLoS Pathog 17(6):e1009632, 2021. e-Pub 2021. PMID: 34061907.
- Arunachalam PS, Walls AC, Golden N, Atyeo C, Fischinger S, Li C, Aye P, Navarro MJ, Lai L, Edara VV, Roltgen K, Rogers K, Shirreff L, Ferrell DE, Wrenn S, Pettie D, Kraft JC, Miranda MC, Kepl E, Sydeman C, Brunette N, Murphy M, Fiala B, Carter L, White AG, Trisal M, Hsieh CL, Russell-Lodrigue K, Monjure C, Dufour J, Spencer S, Doyle-Meyers L, Bohm RP, Maness NJ, Roy C, Plante JA, Plante KS, Zhu A, Gorman MJ, Shin S, Shen X, Fontenot J, Gupta S, O'Hagan DT, Van Der Most R, Rappuoli R, Coffman RL, Novack D, McLellan JS, Subramaniam S, Montefiori D, Boyd SD, Flynn JL, Alter G, Villinger F, Kleanthous H, Rappaport J, Suthar MS, King NP, Veesler D, Pulendran B. Adjuvanting a subunit COVID-19 vaccine to induce protective immunity. Nature 594(7862):253-258, 2021. e-Pub 2021. PMID: 33873199.
- Harper J, Huot N, Micci L, Tharp G, King C, Rascle P, Shenvi N, Wang H, Galardi C, Upadhyay AA, Villinger F, Lifson J, Silvestri G, Easley K, Jacquelin B, Bosinger S, Muller-Trutwin M, Paiardini M. IL-21 and IFNalpha therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques. Nat Commun 12(1):2866, 2021. e-Pub 2021. PMID: 34001890.
- Walls AC, Miranda MC, Pham MN, Schafer A, Greaney A, Arunachalam PS, Navarro MJ, Tortorici MA, Rogers K, O'Connor MA, Shireff L, Ferrell DE, Brunette N, Kepl E, Bowen J, Zepeda SK, Starr T, Hsieh CL, Fiala B, Wrenn S, Pettie D, Sydeman C, Johnson M, Blackstone A, Ravichandran R, Ogohara C, Carter L, Tilles SW, Rappuoli R, O'Hagan DT, Van Der Most R, Van Voorhis WC, McLellan JS, Kleanthous H, Sheahan TP, Fuller DH, Villinger F, Bloom J, Pulendran B, Baric R, King N, Veesler D. Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines. bioRxiv, 2021. e-Pub 2021. PMID: 33758839.
- Chege GK, Adams CH, Keyser AT, Bekker V, Morris L, Villinger FJ, Williamson AL, Chapman RE. Infection of Chinese Rhesus Monkeys with a Subtype C SHIV Resulted in Attenuated In Vivo Viral Replication Despite Successful Animal-to-Animal Serial Passages. Viruses 13(3), 2021. e-Pub 2021. PMID: 33801437.
- S Arunachalam P, Walls AC, Golden N, Atyeo C, Fischinger S, Li C, Aye P, Navarro MJ, Lai L, Edara VV, Roltgen K, Rogers K, Shirreff L, Ferrell DE, Wrenn S, Pettie D, Kraft JC, Miranda MC, Kepl E, Sydeman C, Brunette N, Murphy M, Fiala B, Carter L, White AG, Trisal M, Hsieh CL, Russell-Lodrigue K, Monjure C, Dufour J, Doyle-Meyer L, Bohm RB, Maness NJ, Roy C, Plante JA, Plante KS, Zhu A, Gorman MJ, Shin S, Shen X, Fontenot J, Gupta S, O Hagan DT, Most RV, Rappuoli R, Coffman RL, Novack D, McLellan JS, Subramaniam S, Montefiori D, Boyd SD, Flynn JL, Alter G, Villinger F, Kleanthous H, Rappaport J, Suthar M, King NP, Veesler D, Pulendran B. Adjuvanting a subunit SARS-CoV-2 nanoparticle vaccine to induce protective immunity in non-human primates. bioRxiv, 2021. e-Pub 2021. PMID: 33594366.
- Madden PJ, Arif MS, Becker ME, McRaven MD, Carias AM, Lorenzo-Redondo R, Xiao S, Midkiff CC, Blair RV, Potter EL, Martin-Sancho L, Dodson A, Martinelli E, Todd JM, Villinger FJ, Chanda SK, Aye PP, Roy CJ, Roederer M, Lewis MG, Veazey RS, Hope TJ. Development of an In Vivo Probe to Track SARS-CoV-2 Infection in Rhesus Macaques. Front Immunol 12:810047, 2021. e-Pub 2021. PMID: 35003140.
- Pallikkuth S, Mendez R, Russell K, Sirupangi T, Kvistad D, Pahwa R, Villinger F, Banerjee S, Pahwa S. Age Associated Microbiome and Microbial Metabolites Modulation and Its Association With Systemic Inflammation in a Rhesus Macaque Model. Front Immunol 12:748397, 2021. e-Pub 2021. PMID: 34737748.
- Gong S, Lakhashe SK, Hariraju D, Scinto H, Lanzavecchia A, Cameroni E, Corti D, Ratcliffe SJ, Rogers KA, Xiao P, Fontenot J, Villinger F, Ruprecht RM. Cooperation Between Systemic IgG1 and Mucosal Dimeric IgA2 Monoclonal Anti-HIV Env Antibodies: Passive Immunization Protects Indian Rhesus Macaques Against Mucosal SHIV Challenges. Front Immunol 12:705592, 2021. e-Pub 2021. PMID: 34413855.
- Xiao P, Dienger-Stambaugh K, Chen X, Wei H, Phan S, Beavis AC, Singh K, Adhikary NRD, Tiwari P, Villinger F, He B, Spearman P. Parainfluenza Virus 5 Priming Followed by SIV/HIV Virus-Like-Particle Boosting Induces Potent and Durable Immune Responses in Nonhuman Primates. Front Immunol 12:623996, 2021. e-Pub 2021. PMID: 33717130.
- Watanabe S, Fujino M, Saito Y, Ahmed N, Sato H, Sugimoto C, Okamura T, Hanaki K, Nakayama EE, Shioda T, Matsushima K, Ansari AA, Villinger F, Mori K. Protective Immune Responses Elicited by Deglycosylated Live-Attenuated Simian Immunodeficiency Virus Vaccine Are Associated with IL-15 Effector Functions. J Immunol 205(5):1331-1344, 2020. e-Pub 2020. PMID: 32747501.
- Panigrahi S, Chen B, Fang M, Potashnikova D, Komissarov AA, Lebedeva A, Michaelson GM, Wyrick JM, Morris SR, Sieg SF, Paiardini M, Villinger FJ, Harth K, Kashyap VS, Cameron MJ, Cameron CM, Vasilieva E, Margolis L, Younes SA, Funderburg NT, Zidar DA, Lederman MM, Freeman ML. CX3CL1 and IL-15 Promote CD8 T cell chemoattraction in HIV and in atherosclerosis. PLoS Pathog 16(9):e1008885, 2020. e-Pub 2020. PMID: 32976527.
- Koo BS, Hwang EH, Kim G, Park JY, Oh H, Lim KS, Kang P, Lee HY, Jeong KJ, Mo I, Villinger F, Hong JJ. Prevalence and characterization of Clostridium perfringens isolated from feces of captive cynomolgus monkeys (Macaca fascicularis). Anaerobe 64:102236, 2020. e-Pub 2020. PMID: 32623046.
- Kasturi SP, Rasheed MAU, Havenar-Daughton C, Pham M, Legere T, Sher ZJ, Kovalenkov Y, Gumber S, Huang JY, Gottardo R, Fulp W, Sato A, Sawant S, Stanfield-Oakley S, Yates N, LaBranche C, Alam SM, Tomaras G, Ferrari G, Montefiori D, Wrammert J, Villinger F, Tomai M, Vasilakos J, Fox CB, Reed SG, Haynes BF, Crotty S, Ahmed R, Pulendran B. 3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope-specific plasma cells and humoral immunity in nonhuman primates. Sci Immunol 5(48), 2020. e-Pub 2020. PMID: 32561559.
- Chebloune Y, Moussa M, Arrode-Bruses G, Ronfort C, Bose D, Gagnon J, Gumber S, Villinger T, Byrareddy SN, Kozlowski PA, Gosse L, Dereuddre-Bosquet N, Le Grand R, Villinger F. A single lentivector DNA based immunization contains a late heterologous SIVmac251 mucosal challenge infection. Vaccine 38(21):3729-3739, 2020. e-Pub 2020. PMID: 32278522.
- Singh K, Marasini B, Chen X, Ding L, Wang JJ, Xiao P, Villinger F, Spearman P. A Bivalent, Spherical Virus-Like Particle Vaccine Enhances Breadth of Immune Responses against Pathogenic Ebola Viruses in Rhesus Macaques. J Virol 94(9), 2020. e-Pub 2020. PMID: 32075939.
- Lindsay KE, Vanover D, Thoresen M, King H, Xiao P, Badial P, Arainga M, Park SB, Tiwari PM, Peck HE, Blanchard EL, Feugang JM, Olivier AK, Zurla C, Villinger F, Woolums AR, Santangelo PJ. Aerosol Delivery of Synthetic mRNA to Vaginal Mucosa Leads to Durable Expression of Broadly Neutralizing Antibodies against HIV. Mol Ther 28(3):805-819, 2020. e-Pub 2020. PMID: 31995741.
- Villinger F. In-vivo use of SIVmac239 with a reversing stop codon in the SIV nef gene. AIDS 34(3):487, 2020. e-Pub 2020. PMID: 31996597.
- Shankwitz K, Pallikkuth S, Sirupangi T, Kirk Kvistad D, Russel KB, Pahwa R, Gama L, Koup RA, Pan L, Villinger F, Pahwa S, Petrovas C. Compromised steady-state germinal center activity with age in nonhuman primates. Aging Cell 19(2):e13087, 2020. e-Pub 2020. PMID: 31840398.
- Koo BS, Baek SH, Kim G, Hwang EH, Oh H, Son Y, Lim KS, Kang P, Lee HY, Jeong KJ, Kim YH, Villinger F, Hong JJ. Idiopathic chronic diarrhea associated with dysbiosis in a captive cynomolgus macaque (Macaca fascicularis). J Med Primatol 49(1):56-59, 2020. e-Pub 2020. PMID: 31642533.
- Pino M, Uppada SB, Pandey K, King C, Nguyen K, Shim I, Rogers K, Villinger F, Paiardini M, Byrareddy SN. Safety and Immunological Evaluation of Interleukin-21 Plus Anti-alpha4beta7 mAb Combination Therapy in Rhesus Macaques. Front Immunol 11:1275, 2020. e-Pub 2020. PMID: 32765488.
- Chamcha V, Reddy PBJ, Kannanganat S, Wilkins C, Gangadhara S, Velu V, Green R, Law GL, Chang J, Bowen JR, Kozlowski PA, Lifton M, Santra S, Legere T, Chea LS, Chennareddi L, Yu T, Suthar MS, Silvestri G, Derdeyn CA, Gale M Jr, Villinger F, Hunter E, Amara RR. Strong T(H)1-biased CD4 T cell responses are associated with diminished SIV vaccine efficacy. Sci Transl Med 11(519), 2019. e-Pub 2019. PMID: 31748228.
- Hamorsky KT, Kouokam JC, Dent MW, Grooms TN, Husk AS, Hume SD, Rogers KA, Villinger F, Morris MK, Hanson CV, Matoba N. Engineering of a Lectibody Targeting High-Mannose-Type Glycans of the HIV Envelope. Mol Ther 27(11):2038-2052, 2019. e-Pub 2019. PMID: 31471224.
- Duncan SA, Dixit S, Sahu R, Martin D, Baganizi DR, Nyairo E, Villinger F, Singh SR, Dennis VA. Prolonged Release and Functionality of Interleukin-10 Encapsulated within PLA-PEG Nanoparticles. Nanomaterials (Basel) 9(8), 2019. e-Pub 2019. PMID: 31357440.
- Sindberg GM, Callen SE, Banerjee S, Meng J, Hale VL, Hegde R, Cheney PD, Villinger F, Roy S, Buch S. Morphine Potentiates Dysbiotic Microbial and Metabolic Shifts in Acute SIV Infection. J Neuroimmune Pharmacol 14(2):200-214, 2019. e-Pub 2019. PMID: 30242614.
- Matchett WE, Anguiano-Zarate SS, Nehete PN, Shelton K, Nehete BP, Yang G, Dorta-Estremera S, Barnette P, Xiao P, Byrareddy SN, Villinger F, Hessell AJ, Haigwood NL, Sastry KJ, Barry MA. Divergent HIV-1-Directed Immune Responses Generated by Systemic and Mucosal Immunization with Replicating Single-Cycle Adenoviruses in Rhesus Macaques. J Virol 93(10), 2019. e-Pub 2019. PMID: 30842321.
- Zhou M, Humbert M, Mukhtar MM, Scinto HB, Vyas HK, Lakhashe SK, Byrareddy SN, Maurer G, Thorat S, Owuor J, Lai Z, Chen Y, Griffiths A, Chenine AL, Gumber S, Villinger F, Montefiori D, Ruprecht RM. Adaptation of an R5 Simian-Human Immunodeficiency Virus Encoding an HIV Clade A Envelope with or without Ablation of Adaptive Host Immunity: Differential Selection of Viral Mutants. J Virol 93(9), 2019. e-Pub 2019. PMID: 30760566.
- Calenda G, Frank I, Arrode-Bruses G, Pegu A, Wang K, Arthos J, Cicala C, Rogers KA, Shirreff L, Grasperge B, Blanchard JL, Maldonado S, Roberts K, Gettie A, Villinger F, Fauci AS, Mascola JR, Martinelli E. Delayed vaginal SHIV infection in VRC01 and anti-alpha4beta7 treated rhesus macaques. PLoS Pathog 15(5):e1007776, 2019. e-Pub 2019. PMID: 31083697.
- Lindsay KE, Bhosle SM, Zurla C, Beyersdorf J, Rogers KA, Vanover D, Xiao P, Arainga M, Shirreff LM, Pitard B, Baumhof P, Villinger F, Santangelo PJ. Visualization of early events in mRNA vaccine delivery in non-human primates via PET-CT and near-infrared imaging. Nat Biomed Eng 3(5):371-380, 2019. e-Pub 2019. PMID: 30936432.
- Hoang T, Date AA, Ortiz JO, Young TW, Bensouda S, Xiao P, Marzinke M, Rohan L, Fuchs EJ, Hendrix C, Gumber S, Villinger F, Cone RA, Hanes J, Ensign LM. Development of rectal enema as microbicide (DREAM): Preclinical progressive selection of a tenofovir prodrug enema. Eur J Pharm Biopharm 138:23-29, 2019. e-Pub 2019. PMID: 29802984.
- Petitdemange C, Kasturi SP, Kozlowski PA, Nabi R, Quarnstrom CF, Reddy PBJ, Derdeyn CA, Spicer LM, Patel P, Legere T, Kovalenkov YO, Labranche CC, Villinger F, Tomai M, Vasilakos J, Haynes B, Kang CY, Gibbs JS, Yewdell JW, Barouch D, Wrammert J, Montefiori D, Hunter E, Amara RR, Masopust D, Pulendran B. Vaccine induction of antibodies and tissue-resident CD8+ T cells enhances protection against mucosal SHIV-infection in young macaques. JCI Insight 4(4), 2019. e-Pub 2019. PMID: 30830870.
- Chand HS, Vazquez-Guillamet R, Royer C, Rudolph K, Mishra N, Singh SP, Hussain SS, Barrett E, Callen S, Byrareddy SN, Guillamet MCV, Abukhalaf J, Sheybani A, Exil V, Raizada V, Agarwal H, Nair M, Villinger F, Buch S, Sopori M. Cigarette smoke and HIV synergistically affect lung pathology in cynomolgus macaques. J Clin Invest 128(12):5428-5433, 2018. e-Pub 2018. PMID: 30277472.
- Bhaumik SK, Kulkarni RR, Weldon WC, Silveira ELV, Ahmed H, Gunisetty S, Chandele A, Antia R, Verma H, Sutter R, Pallansch MA, Oberste MS, Villinger F, Orenstein W, Murali-Krishna K. Immune Priming and Long-term Persistence of Memory B Cells After Inactivated Poliovirus Vaccine in Macaque Models: Support for at least 2 Doses. Clin Infect Dis 67(suppl_1):S66-S77, 2018. e-Pub 2018. PMID: 30376091.
- Nawaz F, Goes LR, Ray JC, Olowojesiku R, Sajani A, Ansari AA, Perrone I, Hiatt J, Van Ryk D, Wei D, Waliszewski M, Soares MA, Jelicic K, Connors M, Migueles SA, Martinelli E, Villinger F, Cicala C, Fauci AS, Arthos J. MAdCAM costimulation through Integrin-alpha(4)beta(7) promotes HIV replication. Mucosal Immunol 11(5):1342-1351, 2018. e-Pub 2018. PMID: 29875402.
- Lertjuthaporn S, Cicala C, Van Ryk D, Liu M, Yolitz J, Wei D, Nawaz F, Doyle A, Horowitch B, Park C, Lu S, Lou Y, Wang S, Pan R, Jiang X, Villinger F, Byrareddy SN, Santangelo PJ, Morris L, Wibmer CK, Biris K, Mason RD, Gorman J, Hiatt J, Martinelli E, Roederer M, Fujikawa D, Gorini G, Franchini G, Arakelyan A, Ansari AA, Pattanapanyasat K, Kong XP, Fauci AS, Arthos J. Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to alpha4beta7. PLoS Pathog 14(8):e1007278, 2018. e-Pub 2018. PMID: 30153309.
- Gumber S, Amancha PK, Yen PJ, Villinger F, Gabuzda D, Byrareddy SN. In vivo characterization of macrophage-tropic simian immunodeficiency virus molecular clones in rhesus macaques. J Neurovirol 24(4):411-419, 2018. e-Pub 2018. PMID: 29594984.
- Dave RS, Sharma RK, Muir RR, Haddad E, Gumber S, Villinger F, Nehra AP, Khan ZK, Wigdahl B, Ansari AA, Byrareddy SN, Jain P. FDC:TFH Interactions within Cervical Lymph Nodes of SIV-Infected Rhesus Macaques. J Neuroimmune Pharmacol 13(2):204-218, 2018. e-Pub 2018. PMID: 29288344.
- Santangelo PJ, Cicala C, Byrareddy SN, Ortiz KT, Little D, Lindsay KE, Gumber S, Hong JJ, Jelicic K, Rogers KA, Zurla C, Villinger F, Ansari AA, Fauci AS, Arthos J. Early treatment of SIV+ macaques with an alpha(4)beta(7) mAb alters virus distribution and preserves CD4(+) T cells in later stages of infection. Mucosal Immunol 11(3):932-946, 2018. e-Pub 2018. PMID: 29346349.
- Ramasamy V, Arora U, Shukla R, Poddar A, Shanmugam RK, White LJ, Mattocks MM, Raut R, Perween A, Tyagi P, de Silva AM, Bhaumik SK, Kaja MK, Villinger F, Ahmed R, Johnston RE, Swaminathan S, Khanna N. A tetravalent virus-like particle vaccine designed to display domain III of dengue envelope proteins induces multi-serotype neutralizing antibodies in mice and macaques which confer protection against antibody dependent enhancement in AG129 mice. PLoS Negl Trop Dis 12(1):e0006191, 2018. e-Pub 2018. PMID: 29309412.
- Xiao P, Gumber S, Marzinke MA, Date AA, Hoang T, Hanes J, Ensign LM, Wang L, Rohan L, Fuchs EJ, Hendrix C, Villinger F. Hypo-osmolar Formulation of Tenofovir (TFV) Enema Promotes Uptake and Metabolism of TFV in Tissues, Leading to Prevention of SHIV/SIV Infection. Antimicrob Agents Chemother 62(1), 2018. e-Pub 2018. PMID: 29084755.
- Mendez-Lagares G, Lu D, Merriam D, Baker CA, Villinger F, Van Rompay KKA, McCune JM, Hartigan-O'Connor DJ. IL-21 Therapy Controls Immune Activation and Maintains Antiviral CD8(+) T Cell Responses in Acute Simian Immunodeficiency Virus Infection. AIDS Res Hum Retroviruses 33(S1):S81-S92, 2017. e-Pub 2017. PMID: 29140110.
- Merriam D, Chen C, Mendez-Lagares G, Rogers KA, Michaels AJ, Yan J, Casaz P, Reimann KA, Villinger F, Hartigan-O'Connor DJ. Depletion of Gut-Resident CCR5(+) Cells for HIV Cure Strategies. AIDS Res Hum Retroviruses 33(S1):S70-S80, 2017. e-Pub 2017. PMID: 28918646.
- Daggett GJ Jr, Zhao C, Connor-Stroud F, Oviedo-Moreno P, Moon H, Cho MW, Moench T, Anderson DJ, Villinger F. Comparison of the vaginal environment in rhesus and cynomolgus macaques pre- and post-lactobacillus colonization. J Med Primatol 46(5):232-238, 2017. e-Pub 2017. PMID: 28488364.
- Hong JJ, Silveira ELDV, Amancha PK, Byrareddy SN, Gumber S, Chang KT, Ansari AA, Villinger F. Early initiation of antiretroviral treatment postSIV infection does not resolve lymphoid tissue activation. AIDS 31(13):1819-1824, 2017. e-Pub 2017. PMID: 28692537.
- Silveira ELV, Rogers KA, Gumber S, Amancha P, Xiao P, Woollard SM, Byrareddy SN, Teixeira MM, Villinger F. Immune Cell Dynamics in Rhesus Macaques Infected with a Brazilian Strain of Zika Virus. J Immunol 199(3):1003-1011, 2017. e-Pub 2017. PMID: 28667164.
- Fujino M, Sato H, Okamura T, Uda A, Takeda S, Ahmed N, Shichino S, Shiino T, Saito Y, Watanabe S, Sugimoto C, Kuroda MJ, Ato M, Nagai Y, Izumo S, Matsushima K, Miyazawa M, Ansari AA, Villinger F, Mori K. Simian Immunodeficiency Virus Targeting of CXCR3(+) CD4(+) T Cells in Secondary Lymphoid Organs Is Associated with Robust CXCL10 Expression in Monocyte/Macrophage Subsets. J Virol 91(13), 2017. e-Pub 2017. PMID: 28424283.
- Zhao C, Gunawardana M, Villinger F, Baum MM, Remedios-Chan M, Moench TR, Zeitlin L, Whaley KJ, Bohorov O, Smith TJ, Anderson DJ, Moss JA. Pharmacokinetics and Preliminary Safety of Pod-Intravaginal Rings Delivering the Monoclonal Antibody VRC01-N for HIV Prophylaxis in a Macaque Model. Antimicrob Agents Chemother 61(7), 2017. e-Pub 2017. PMID: 28416548.
- Kasturi SP, Kozlowski PA, Nakaya HI, Burger MC, Russo P, Pham M, Kovalenkov Y, Silveira ELV, Havenar-Daughton C, Burton SL, Kilgore KM, Johnson MJ, Nabi R, Legere T, Sher ZJ, Chen X, Amara RR, Hunter E, Bosinger SE, Spearman P, Crotty S, Villinger F, Derdeyn CA, Wrammert J, Pulendran B. Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5alpha Restrictive Macaques. J Virol 91(4), 2017. e-Pub 2017. PMID: 27928002.
- Voss JE, Macauley MS, Rogers KA, Villinger F, Duan L, Shang L, Fink EA, Andrabi R, Colantonio AD, Robinson JE, Johnson RP, Burton DR, Haase AT. Reproducing SIVDeltanef vaccine correlates of protection: trimeric gp41 antibody concentrated at mucosal front lines. AIDS 30(16):2427-2438, 2016. e-Pub 2016. PMID: 27428745.
- Byrareddy SN, Arthos J, Cicala C, Villinger F, Ortiz KT, Little D, Sidell N, Kane MA, Yu J, Jones JW, Santangelo PJ, Zurla C, McKinnon LR, Arnold KB, Woody CE, Walter L, Roos C, Noll A, Van Ryk D, Jelicic K, Cimbro R, Gumber S, Reid MD, Adsay V, Amancha PK, Mayne AE, Parslow TG, Fauci AS, Ansari AA. Sustained virologic control in SIV+ macaques after antiretroviral and alpha4beta7 antibody therapy. Science 354(6309):197-202, 2016. e-Pub 2016. PMID: 27738167.
- Velu V, Mylvaganam GH, Gangadhara S, Hong JJ, Iyer SS, Gumber S, Ibegbu CC, Villinger F, Amara RR. Induction of Th1-Biased T Follicular Helper (Tfh) Cells in Lymphoid Tissues during Chronic Simian Immunodeficiency Virus Infection Defines Functionally Distinct Germinal Center Tfh Cells. J Immunol 197(5):1832-42, 2016. e-Pub 2016. PMID: 27481845.
- Clark KB, Hsiao HM, Bassit L, Crowe JE Jr, Schinazi RF, Perng GC, Villinger F. Characterization of dengue virus 2 growth in megakaryocyte-erythrocyte progenitor cells. Virology 493:162-72, 2016. e-Pub 2016. PMID: 27058763.
- Gumber S, Nascimento FS, Rogers KA, Bishop HS, Rivera HN, Xayavong MV, Devare SG, Schochetman G, Amancha PK, Qvarnstrom Y, Wilkins PP, Villinger F. Experimental transfusion-induced Babesia microti infection: dynamics of parasitemia and immune responses in a rhesus macaque model. Transfusion 56(6 Pt 2):1508-19, 2016. e-Pub 2016. PMID: 26892459.
- Burghuber CK, Kwun J, Page EJ, Manook M, Gibby AC, Leopardi FV, Song M, Farris AB 3rd, Hong JJ, Villinger F, Adams AB, Iwakoshi NN, Knechtle SJ. Antibody-Mediated Rejection in Sensitized Nonhuman Primates: Modeling Human Biology. Am J Transplant 16(6):1726-38, 2016. e-Pub 2016. PMID: 26705099.
- Panigrahi S, Freeman ML, Funderburg NT, Mudd JC, Younes SA, Sieg SF, Zidar DA, Paiardini M, Villinger F, Calabrese LH, Ransohoff RM, Jain MK, Lederman MM. SIV/SHIV Infection Triggers Vascular Inflammation, Diminished Expression of Kruppel-like Factor 2 and Endothelial Dysfunction. J Infect Dis 213(9):1419-27, 2016. e-Pub 2016. PMID: 26671887.
- Ofotokun I, Titanji K, Vunnava A, Roser-Page S, Vikulina T, Villinger F, Rogers K, Sheth AN, Lahiri CD, Lennox JL, Weitzmann MN. Antiretroviral therapy induces a rapid increase in bone resorption that is positively associated with the magnitude of immune reconstitution in HIV infection. AIDS 30(3):405-14, 2016. e-Pub 2016. PMID: 26760232.
- Konadu KA, Huang MB, Roth W, Armstrong W, Powell M, Villinger F, Bond V. Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals. J Vis Exp(107), 2016. e-Pub 2016. PMID: 26780239.
Review Articles
- Arthos J, Cicala C, Nawaz F, Byrareddy SN, Villinger F, Santangelo PJ, Ansari AA, Fauci AS. The Role of Integrin alpha(4)beta(7) in HIV Pathogenesis and Treatment. Curr HIV/AIDS Rep 15(2):127-135, 2018. e-Pub 2018. PMID: 29478152.
- Anderson DJ, Politch JA, Zeitlin L, Hiatt A, Kadasia K, Mayer KH, Ruprecht RM, Villinger F, Whaley KJ. Systemic and topical use of monoclonal antibodies to prevent the sexual transmission of HIV. AIDS 31(11):1505-1517, 2017. e-Pub 2017. PMID: 28463876.
Other Articles
- Kim J, Bose D, Arainga M, Haque MR, Fennessey CM, Caddell RA, Thomas Y, Ferrell DE, Ali S, Grody E, Goyal Y, Cicala C, Arthos J, Keele BF, Vaccari M, Lorenzo-Redondo R, Hope TJ, Villinger F, Martinelli E Publisher Correction: TGF-beta blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo. Nat Commun 15(1):8787, 2024. PMID: 39389943.
- Samer S, Thomas Y, Arainga M, Carter C, Shirreff LM, Arif MS, Avita JM, Frank I, McRaven MD, Thuruthiyil CT, Heybeli VB, Anderson MR, Owen B, Gaisin A, Bose D, Simons LM, Hultquist JF, Arthos J, Cicala C, Sereti I, Santangelo PJ, Lorenzo-Redondo R, Hope TJ, Villinger FJ, Martinelli E Blockade of TGF-beta signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo. JCI Insight 8(22), 2023. PMID: 37991025.
- Weidenbacher PA, Sanyal M, Friedland N, Tang S, Arunachalam PS, Hu M, Kumru OS, Morris MK, Fontenot J, Shirreff L, Do J, Cheng YC, Vasudevan G, Feinberg MB, Villinger FJ, Hanson C, Joshi SB, Volkin DB, Pulendran B, Kim PS Author Correction: A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates. Nat Commun 14(1):6211, 2023. PMID: 37798288.
Book Chapters
- Villinger F. Application of the TSR-Based Method in Detecting and Quantifying Ligand- Induced Conformational Changes of 14-3-3 Proteins. In: Computational Approaches in Drug Design. Springer, 2026.
Patents
- Aftab A Ansari, Villinger F, Kenneth W Sell. Noninvasive Diagnosis for Allograft Rejection. Patent Number: 5,635,365.
Patient Reviews
CV information above last modified March 09, 2026