About Dr. Lang
Frederick Lang, MD, FACS, FAANS is Professor and Director of Clinical Research in the Department of Neurosurgery at MD Anderson. He is also Adjunct Professor of Neurosurgery at Baylor College of Medicine, Houston. Dr. Lang was born in Brooklyn, NY. He received his medical degree from Yale University School of Medicine, New Haven, CT. He completed a residency in neurosurgery at New York University Medical Center, and a fellowship in neurosurgical oncology at MD Anderson. Dr. Lang is the recipient of numerous awards and honors, including America's Top Doctors for Cancer, Guide to America's Top Surgeons, the Preuss Research Award, the Mahaley Award, the Journal of Neuro-Oncology Award, the Michael S. Voynick Award in Neuro-Oncology, the Perlman Lectureship, and the Otto Lein da Wong Lecture from the Chinese University of Hong Kong. He is the Principal Investigator of the multi-disciplinary SPORE in Brain Cancer Program grant. He is a NIH-funded translational researcher who has published extensively on gene, viral and cellular therapies for brain tumors and is Principal Investigator on multiple clinical trials that investigate these new approaches. He has served on the Executive Committee of the AANS/CNS Section on Tumors and is the past Chair of this section. He is a member of the Board of Directors of the Society for Neuro-Oncology (SNO), and is a past President of SNO. He is board certified in Neurosurgery and is a Fellow of the American College of Surgeons and the American Association of Neurological Surgeons. Dr. Lang is an Associate Editor of Neurosurgery and on the Editorial Board of Neuro-Oncology and Translational Oncology. He served on the Developmental Therapeutic Study Section within the NIH until his tenure ended in 2011, he has continued as an ad hoc reviewer for NIH. He is frequently requested as a national and international lecturer. He has published more than 200 peer-reviewed articles and book chapters. Dr. Lang is a leader in the field of neurosurgery with particular focus on deep seated brain tumors located in eloquent brain regions.
Professor (tenure), Department of Neurosurgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
Director of Clinical Research, Department of Neurosurgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
Faculty Member, The University of Texas MD Anderson Cancer Center, Graduate School of Biomedical Sciences, Houston, TX
Adjunct Professor, Department of Neurosurgery, Baylor College of Medicine, Houston, TX
|1988||Yale University School of Medicine, New Haven, CT, USA, MD, Medicine|
|1984||Yale College, Yale University, New Haven, CT, USA, BS, Biology|
|1995-1996||Clinical Fellowship, Neurosurgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX|
|1993-1995||Clinical Residency, Chief Resident, Department of Neurosurgery, New York University Medical Center, New York, NY|
|1989-1993||Clinical Residency, Department of Neurosurgery, New York University Medical Center, New York, NY|
|1988-1989||Clinical Internship, General Surgery, New York University Medical Center, New York, NY|
|2000||The American Board of Neurological Surgery|
|2007||Global Directory of Who's Who|
|2004||America's Top Doctors for Cancer|
|2003||Best Doctors in America|
- Doucette T, Rao G, Yang Y, Gumin J, Shinojima N, Bekele BN, Qiao W, Zhang W, Lang FF. Mesenchymal stem cells display tumor specific tropism in an RCAS/Ntv-a glioma model. Neoplasia 13(8):716-25, 2011. PMID: 21847363.
- Hata N, Shinojima N, Gumin J, Yong R, Marini F, Andreeff M, Lang FF. Platelet-derived growth factor BB mediates the tropism of human mesenchymal stem cells for malignant gliomas. Neurosurgery 66(1):144-156; discussion 156-157, 2010. PMID: 20023545.
- Wei J, Barr J, Kong LY, Wang Y, Wu A, Sharma AK, Gumin J, Henry V, Colman H, Priebe W, Sawaya R, Lang FF, Heimberger AB. Glioblastoma cancer-initiating cells inhibit T-cell proliferation and effector responses by the signal transducers and activators of transcription 3 pathway. Mol Cancer Ther 9(1):67-78, 2010. PMID: 20053772.
- He H, Nilsson CL, Emmett MR, Marshall AG, Kroes RA, Moskal JR, Ji Y, Colman H, Priebe W, Lang FF, Conrad CA. Glycomic and transcriptomic response of GSC11 glioblastoma stem cells to STAT3 phosphorylation inhibition and serum-induced differentiation. J Proteome Res 9(5):2098-108, 2010. PMID: 20199106.
- Kang S, Shinojima N, Hossain A, Gumin J, Yong R, Colman H, Marini F, Andreeff M, Lang FF. Isolation and perivascular localization of mesenchymal stem cells from mouse brain. Neurosurgery 67(3):711-20, 2010. PMID: 20651630.
- Williams BJ, Suki D, Fox BD, Maldaun MVC, Sawaya RE, Lang FF, Rao G. Stereotactic radiosurgery for metastatic brain tumors: a comprehensive review of complications. J Neurosurg 111(3):439-448, 2009. PMID: 19301968.
- Yong R, Shinojima N, Fueyo J, Gumin J, Vecil GG, Marini FC, Bogler O, Andreeff M, Lang FF. Human bone marrow-derived mesenchymal stem cells for intravascular delivery of oncolytic adenovirus Delta-24-RGD to human gliomas. Cancer Res 69(23):8932-8940, 2009. PMID: 19920199.
- Kim SS, McCutcheon IE, Suki D, Weinberg JS, Sawaya R, Lang FF, Ferson D, Heimberger AB, DeMonte F, Prabhu SS. Awake craniotomy for brain tumors near eloquent cortex: correlation of intraoperative cortical mapping with neurological outcomes in 309 consecutive patients. Neurosurgery 64(5):836-46, 2009. PMID: 19404147.
- Amano T, Nakamizo A, Mishra SK, Gumin J, Shinojima N, Sawaya R, Lang FF. Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes. J Neurooncol 92(3):357-71, 2009. PMID: 19357962.
- Tatsui CE, Lang FF, Gumin J, Suki D, Shinojima N, Rhines LD. An orthotopic murine model of human spinal metastasis: histological and functional correlations. J Neurosurg Spine 10(6):501-512, 2009. PMID: 19558282.
- Toms SA, Weil RJ, Gupta A, Boulis NM, Prayson R, Lang FF. Clinical problem solving: island intruder. Neurosurgery 62(4):920-8; discussion 928-9, 2008. PMID: 18496198.
- Alonso MM, Jiang H, Yokoyama T, Xu J, Bekele NB, Lang FF, Kondo S, Gomez-Manzano C, Fueyo J. Delta-24-RGD in combination with RAD001 induces enhanced anti-glioma effect via autophagic cell death. Mol Ther 16(3):487-93, 2008. PMID: 18253154.
- Nakamizo A, Amano T, Zhang W, Zhang XQ, Ramdas L, Liu TJ, Bekele BN, Shono T, Sasaki T, Benedict WF, Sawaya R, Lang FF. Phosphorylation of Thr18 and Ser20 of p53 in Ad-p53-induced apoptosis. Neuro Oncol 10(3):275-291, 2008. PMID: 18443131.
- Gilbert MR, Lang FF. Management of patients with low-grade gliomas. Neurol Clin 25(4):1073-88, 2007. PMID: 17964026.
- Gilbert MR, Lang FF. Should patients with anaplastic oligodendroglial tumors receive adjuvant chemotherapy. Nat Clin Pract Neurol 3(1):14-5, 2007. PMID: 17205067.
- Gilbert MR, Lang FF. Anaplastic oligodendroglial tumors: a tale of two trials. J Clin Oncol 24(18):2689-90, 2006.
- Wu A, Lang FF. Insular Tumors. In: Mehta MP, Chang SM, Guha A, Newton HB, Vogelbaum MA (eds). In: Principles and Practice of Neuro-Oncology: A Multidisciplinary Approach. Demos Medical Publishers: New York, NY, 505-17, 2011.
- Chern JJ, Rao G, Lang FF. Medulloblastoma. In: Winn HR (ed). In: Youmans Neurological Surgery. 6th ed. 6th. Elsevier Saunders: Philadelphia, PA, 1373-82, 2011.
- Lang FF, Chang EL, Suki D, Wildrick DM, Sawaya R. Metastatic Brain Tumors. In: Winn HR, (ed). In: Youmans Neurological Surgery, 6th Edition. 6th. Elsevier Saunders: Philadelphia, PA, 1410-25, 2011.
- Sawaya R, Bindal RK, Lang FF, Suki D. Metastatic Brain Tumors. In: Kaye AH, Laws ER, (eds). In: Brain Tumors: An Encyclopedic Approach. 3rd Edition. Elsevier Saunders: Philadelphia, PA, 864-92, 2011.
|Title:||SPORE in Brain Cancer Core A: Administrative Core|
|Title:||SPORE in Brain Cancer Career Development Program|
|Title:||MSCs as Natural Bio-Factories for Nanosized Exosomes Carrying STAT3 siRNA, SPORE in Brain Cancer Developmental Research Program|
|Title:||SPORE in Brain Cancer|
|Title:||Bone marrow-derived mesenchymal stem cells in the treatment of human ependymomas|
|Funding Source:||Collaborative Ependymoma Research Network (CERN) Foundation|
Frederick Lang, M.D., is a leader in the field of neurosurgery, with a particular focus on deep seated brain tumors located in eloquent brain regions.
Frederick Lang, M.D., with his 2016 lab team.
The Broach Foundation for Brain Cancer Research has pledged $5 million to Dr. Lang's brain tumor research at MD Anderson.